MedWorm: Ambien

Zolpidem: Nocturnal sleep-related eating disorder: case report

Reactions — Sun, 05 Feb 2012 18:29:54 +0100

(Source: Reactions)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Zolpidem: Somnambulism in an elderly patient: case report

Reactions — Sun, 05 Feb 2012 18:29:54 +0100

(Source: Reactions)

Zolpidem: Sleep driving: case report

Reactions — Thu, 02 Feb 2012 18:34:27 +0100

(Source: Reactions)

Zolpidem withdrawal: Delirium: case report

Reactions — Thu, 02 Feb 2012 18:34:27 +0100

(Source: Reactions)

ZOLPIDEM TARTRATE EXTENDED RELEASE (Zolpidem Tartrate) Tablet, Film Coated, Extended Release [Par Pharmaceutical, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Feb 2012 05:00:00 +0100

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

New Sleeping Pill: Intermezzo May Help You Get Back to Sleep

About Sleep Disorders — Mon, 30 Jan 2012 05:00:00 +0100

If you have trouble waking up in the middle of the night and not being able to get back to sleep, you may have a new treatment available for your insomnia: Intermezzo. Intermezzo is a lower dose of the popular sleeping pill called Ambien. It is safe to take in the middle of the night and it won't leave you feeling "hungover" in the morning. For those with insomnia characterized by middle of the night awakenings, this medication might be just the thing to get you back to sleep. Read More About Sleeping Pills: Intermezzo Sleeping Pill Targets Middle-of-the-Night Awakenings Sleeping Pills Overview How to Take Melatonin Ambien: Insomnia Treatment Option Insomnia Treatment: Nonbenzodiazepine Medications Follow me on Twitter or Facebook to receive notice of all the latest upda...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

AMBIEN CR (Zolpidem Tartrate) Tablet, Coated [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 30 Jan 2012 05:00:00 +0100

Updated Date: Jan 30, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia

Neuropsychopharmacology — Wed, 11 Jan 2012 05:00:00 +0100

Authors: Paolo Bettica, Lisa Squassante, John A Groeger, Brian Gennery, Raphaelle Winsky-Sommerer & Derk-Jan Dijk Keywords: psychopharmacology; chronobiology/sleep; clinical pharmacology; clinical trials; drug discovery/development; orexins/hypocretins; circadian; insomnia; hypnotics; SB-649868 (Source: Neuropsychopharmacology)

ZOLPIDEM TARTRATEtablet [STAT RX USA LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 10 Jan 2012 05:00:00 +0100

Updated Date: Jan 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet, Film Coated [Roxane Laboratories, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 04 Jan 2012 05:00:00 +0100

Updated Date: Jan 4, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

zolpidem, Intermezzo

MedicineNet Medications General — Tue, 03 Jan 2012 07:00:00 +0100

Title: zolpidem, IntermezzoCategory: MedicationsCreated: 1/3/2012 6:19:00 PMLast Editorial Review: 1/3/2012 6:19:55 PM (Source: MedicineNet Medications General)

MedWorm Sponsor Message: Find the best January Sales in the UK.

The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses

Sleep — Mon, 02 Jan 2012 13:58:37 +0100

The International Classification of Sleep Disorders, Second Edition (ICSD-2) distinguishes 5 subtypes of central sleep apnea syndromes (CSAS) in adults. Review of the literature suggests that there are two basic mechanisms that trigger central respiratory events: (1) post-hyperventilation central apnea, which may be triggered by a variety of clinical conditions, and (2) central apnea secondary to hypoventilation, which has been described with opioid use. The preponderance of evidence on the treatment of CSAS supports the use of continuous positive airway pressure (CPAP). Much of the evidence comes from investigations on CSAS related to congestive heart failure (CHF), but other subtypes of CSAS appear to respond to CPAP as well. Limited evidence is available to support alternative therapies...

Effects of GF-015535-00, a Novel α1 GABAA Receptor Ligand, on the Sleep-Wake Cycle in Mice, with Reference to Zolpidem

Sleep — Mon, 02 Jan 2012 13:58:37 +0100

Conclusion:The characteristics of the sleep-wake effects of GF-015535-00 in mice could be potentially beneficial for its use as a therapeutic compound in the treatment of insomnia. Further investigations are required to assess whether the same characteristics are conserved in other animal models and humans.Citation:Anaclet C; Zhang M; Zhao C; Buda C; Seugnet L; Lin JS. Effects of GF-015535-00, a novel α1 GABAA receptor ligand, on the sleep-wake cycle in mice, with reference to zolpidem. SLEEP 2012;35(1):103-111. (Source: Sleep)

Zolpidem ingestion, automatisms, and sleep driving: a clinical and legal case series. - Poceta JS.

SafetyLit: All (Unduplicated) — Sun, 01 Jan 2012 12:07:07 +0100

STUDY OBJECTIVES: To describe zolpidem-associated complex behaviors, including both daytime automatisms and sleep-related parasomnias. METHODS: A case series of eight clinical patients and six legal defendants is presented. Patients presented to the author... (Source: SafetyLit: All (Unduplicated))

ZOLPIDEM TARTRATEtablet, Film Coated [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 29 Dec 2011 05:00:00 +0100

Updated Date: Dec 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

ZOLPIDEM TARTRATEtablet, Film Coated [McKesson Contract Packaging]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 23 Dec 2011 05:00:00 +0100

Updated Date: Dec 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Benzodiazepine use in Belgian nursing homes: a closer look into indications and dosages

European Journal of Clinical Pharmacology — Wed, 21 Dec 2011 20:06:35 +0100

Conclusion Efforts to reduce the use of BZD/Zs in nursing homes should concentrate on insomnia, with interventions aimed at reducing too high prevalence of chronic use and too high daily dosages in this indication. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-12DOI 10.1007/s00228-011-1188-zAuthors Jolyce Bourgeois, Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185 (1 blok B), 9000 Ghent, BelgiumMonique M. Elseviers, Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185 (1 blok B), 9000 Ghent, BelgiumMajda Azermai, Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185 (1 blok B), 9000 Ghent, BelgiumLuc Van Bortel, Heymans Institute of Pharmacology, Ghent University, De Pintelaan 1...

What Role Will Intermezzo® Play in Treating Insomnia?What Role Will Intermezzo® Play in Treating Insomnia?

Medscape Today Headlines — Tue, 20 Dec 2011 17:54:58 +0100

The zolpidem tartrate sublingual tablet was recently approved for insomnia characterized by middle-of-the-night wakening. But how should prescribers use the new agent? Medscape Neurology (Source: Medscape Today Headlines)

ZOLPIDEM TARTRATEtablet, Film Coated, Extended Release [American Health Packaging]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 20 Dec 2011 05:00:00 +0100

Updated Date: Dec 20, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Zolpidem Ingestion, Automatisms, and Sleep Driving: A Clinical and Legal Case Series

Journal of Clinical Sleep Medicine : JCSM — Wed, 14 Dec 2011 21:29:02 +0100

Conclusions:Sleep driving and other complex behaviors can occur after zolpidem ingestion. Physicians should assess patients for potential risk factors and inquire about parasomnias. Serious legal and medical complications can occur as a result of these forms of automatic complex behaviors.Citation:Poceta JS. Zolpidem ingestion, automatisms, and sleep driving: a clinical and legal case series. J Clin Sleep Med 2011;7(6):632-638. (Source: Journal of Clinical Sleep Medicine : JCSM)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Molecules, Money, and Ambien Awakenings

Forbes.com Healthcare News — Tue, 13 Dec 2011 17:47:23 +0100

(Source: Forbes.com Healthcare News)

AMBIEN CR (Zolpidem Tartrate) Tablet, Coated [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 13 Dec 2011 05:00:00 +0100

Updated Date: Dec 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The Brown University Psychopharmacology Update — Fri, 09 Dec 2011 03:36:17 +0100

AbstractIncreasing Off‐Label Use of Antipsychotics for Treating Anxiety DisordersLow‐Dose Antipsychotics Generally Safe in Patients with Intellectual Disability, but Caution Still AdvisedWarfarin and AntidepressantsClinical Guidance for Long‐Term T3 Augmentation in Major DepressionGreater Fracture Risk with Zolpidem Than Alprazolam or Lorazepam in the ElderlySlowing AD Progression with MemantineEPA Supplements for DepressionRisperidone and Decompensation in a Previously Stable PatientNew ApprovalsVarenicline Safety ReviewAdverse Linezolid Interactions with Certain Serotonergic Drugs (Source: The Brown University Psychopharmacology Update)

Intermezzo (Zolpidem Tartrate) - updated on RxList

RxList - New and Updated Drug Monographs — Mon, 05 Dec 2011 07:00:00 +0100

Intermezzo (Zolpidem Tartrate) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

Psychopharmacology of REM Sleep and Dreams

Psychology Today Addiction Center — Sun, 04 Dec 2011 20:27:01 +0100

All the most commonly prescribed drugs for mental and emotional disorders affect dreams—typically via their effects on REM sleep. Under healthy conditions REM sleep ‘turns-on' when activity levels of the biogenic amines (e.g. noradrenaline) decrease and activity levels of acetylcholine increase. Primary Topic: Psychiatry read more (Source: Psychology Today Addiction Center)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Ambien May Wake Some from Minimally Conscious State

About Sleep Disorders — Sun, 04 Dec 2011 05:00:00 +0100

A recent New York Times Magazine article called "A Drug That Wakes the Near Dead" discusses the use of Ambien as a treatment that may wake some from a minimally conscious state. The minimally conscious state describes individuals who often have experienced a brain injury and emerge from a coma with persistent impaired consciousness. (Consciousness is defined as an awareness of yourself and your surroundings.) People in the minimally conscious state have limited awareness and may follow simple commands, give "yes or no" responses, verbalize, or move purposefully. Unfortunately, many people in a minimally conscious state are significantly impaired. These individuals typically require a high level of care, often dependent and living in a nursing home. Doctors have sought ways to return thes...

MSLT in Primary Insomnia: Stability and Relation to Nocturnal Sleep

Sleep — Fri, 02 Dec 2011 20:45:23 +0100

Conclusions:These data support the hypothesis that some insomniacs show a reliable disorder of hyperarousal with increased wake drive both at night and during the day.Citation:Roehrs TA; Randall S; Harris E; Maan R; Roth T. MSLT in primary insomnia: stability and relation to nocturnal sleep. SLEEP 2011;34(12):1647-1652. (Source: Sleep)

FDA Approves First Insomnia Drug for Middle-of-the-night Waking

NurseZone.com Nursing News — Thu, 01 Dec 2011 15:31:25 +0100

November 28, 2011 - The U.S. Food and Drug Administration has approved Intermezzo (zolpidem tartrate sublingual tablets) for use as needed to treat insomnia characterized by middle-of-the-night waking followed by difficulty returning to sleep. (Source: NurseZone.com Nursing News)

Can Ambien Wake the Near-Dead?

NYT Health — Thu, 01 Dec 2011 13:20:16 +0100

A surprising drug has brought a kind of consciousness to patients once considered vegetative — and changed the debate over pulling the plug. (Source: NYT Health)

Sleep aid toxicosis in dogs: 317 cases (2004–2010)

Journal of Veterinary Emergency and Critical Care — Thu, 01 Dec 2011 05:00:00 +0100

ConclusionsOverall, the prognosis for dogs with sleep aid medication toxicosis was excellent, and no fatalities were reported in this clinical population. As significant clinical signs can still be seen with ingestion, appropriate decontamination is warranted in asymptomatic patients via emesis or gastric lavage, followed by activated charcoal administration. Symptomatic patients should be hospitalized for monitoring and supportive care for a minimum of 12 hours or until clinical signs resolve. (Source: Journal of Veterinary Emergency and Critical Care)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Monthly Roundup - November 2011

Drugs.com - Pharma News — Thu, 01 Dec 2011 01:11:36 +0100

Intermezzo Approved for Middle of Night Insomnia Intermezzo (zolpidem tartrate), a low-dose, sublingual form of zolpidem tartrate, was FDA-approved for insomnia associated with middle-of-the night awakenings. Zolpidem is also available in a... (Source: Drugs.com - Pharma News)

Tell us about your drug use - legal and otherwise

Guardian Unlimited Science — Wed, 30 Nov 2011 17:12:20 +0100

Prescription drug abuse if rife, perhaps even at epidemic levels. That's why we really need a clearer picture of who is using what, and when and why. Please read about our drug use surveyIt is fashionable and illicit drugs which tend to attract notoriety and media headlines and dominate public debate: cocaine, heroin, ecstasy and more recently, mephedrone and synthetic cannabis.But a largely under-reported drug story, in the US and other developed nations, is that the drugs most likely to top overdose statistics (and currently causing the greatest ripples in public health circles) are in fact prescribed medications such as opioid pain-killers and sleeping tablets.Prescription medicine abuse is rife, perhaps even at epidemic levels. The US has seen an unprecedented rise in drug-related over...

FDA approves first drug to treat specific type of insomnia

Drug Topics - Top News — Tue, 29 Nov 2011 05:00:00 +0100

FDA approved zolpidem tartrate sublingual tablets (Intermezzo, Transcept Pharmaceuticals) for use as needed to treat insomnia characterized by middle-of-the-night waking followed by difficulty returning to sleep. (Source: Drug Topics - Top News)

FDA approves Intermezzo sublingual tablet for insomnia

Pharmaceutical Technology — Mon, 28 Nov 2011 19:04:00 +0100

The US Food and Drug Administration (FDA) has approved Transcept Pharmaceuticals' Intermezzo (zolpidem tartrate) C-IV, used to treat insomnia.Post to:Delicious Digg reddit Facebook StumbleUpon (Source: Pharmaceutical Technology)

Drug treats middle-of-the-night insomnia

Health News - UPI.com — Mon, 28 Nov 2011 02:35:22 +0100

WASHINGTON, Nov. 27 (UPI) -- Intermezzo, zolpidem tartrate tablets for under the tongue, has been approved by the U.S. government to treat middle-of-the-night insomnia, officials say. (Source: Health News - UPI.com)

FDA Approves First Insomnia Drug For Middle-of-the-Night Waking Followed By Difficulty Returning To Sleep

Health News from Medical News Today — Thu, 24 Nov 2011 09:00:00 +0100

The U.S. Food and Drug Administration approved Intermezzo (zolpidem tartrate sublingual tablets) for use as needed to treat insomnia characterized by middle-of-the-night waking followed by difficulty returning to sleep. This is the first time the FDA has approved a drug for this condition. Intermezzo should only be used when a person has at least four hours of bedtime remaining. It should not be taken if alcohol has been consumed or with any other sleep aid. Insomnia is a common condition in which a person has trouble falling or staying asleep... (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Find the best January Sales in the UK.

US FDA approves zolpidem tartrate (Intermezzo) for middle-of-the-night waking followed by difficulty returning to sleep

NeLM - News — Thu, 24 Nov 2011 05:00:00 +0100

Source: US FDA Area: News The U.S. Food and Drug Administration (FDA) has approved Intermezzo (zolpidem tartrate sublingual tablets) for use as needed to treat insomnia characterised by middle-of-the-night waking followed by difficulty returning to sleep. Intermezzo should only be used when a person has at least four hours of bedtime remaining. It should not be taken if alcohol has been consumed or with any other sleep aid. (Source: NeLM - News)

FDA Approves First Insomnia Drug For Middle-of-the-Night Waking

Health News from Medical News Today — Thu, 24 Nov 2011 03:00:00 +0100

The FDA announced that it has approved Intermezzo (zolpidem tartrate sublingual tablets) that can be used to treat middle of the night waking, where the person has difficulty getting back to sleep. The drug is only for use after four hours sleep, and not in cases where other medication or alcohol has been consumed. Insomnia is relatively common, many people suffer from it from time to time, and it's characterized by a condition in which a person has trouble falling or staying asleep. It can range from mild to severe, depending on how often it occurs and for how long... (Source: Health News from Medical News Today)

Low-Dose Zolpidem Gets FDA Okay for Wee-Hours Awakening

MedPage Today Psychiatry — Thu, 24 Nov 2011 01:13:14 +0100

(MedPage Today) -- A new formulation of the insomnia drug zolpidem tartrate (Ambien) has been approved to treat middle-of-the-night awakenings followed by difficulty returning to sleep, the FDA said. (Source: MedPage Today Psychiatry)

FDA Approves Intermezzo for Middle-of-the-Night Waking Followed by Difficulty Returning to Sleep

Drugs.com - New Drug Approvals — Wed, 23 Nov 2011 21:11:31 +0100

November 23, 2011 -- The U.S. Food and Drug Administration today approved Intermezzo (zolpidem tartrate sublingual tablets) for use as needed to treat insomnia characterized by middle-of-the-night waking followed by difficulty returning to sleep. ... (Source: Drugs.com - New Drug Approvals)

FDA Approves Intermezzo, First Drug for Early WakeningFDA Approves Intermezzo, First Drug for Early Wakening

Medscape Today Headlines — Wed, 23 Nov 2011 20:38:14 +0100

The FDA announced approval today a new formulation of zolpidem (Intermezzo) for insomnia characterized by middle-of-the-night wakening followed by difficulty returning to sleep. FDA Approvals (Source: Medscape Today Headlines)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

FDA approves first insomnia drug for middle-of-the-night waking followed by difficulty returning to sleep

Food and Drug Administration — Wed, 23 Nov 2011 17:58:00 +0100

The U.S. Food and Drug Administration today approved Intermezzo (zolpidem tartrate sublingual tablets) for use as needed to treat insomnia characterized by middle-of-the-night waking followed by difficulty returning to sleep. (Source: Food and Drug Administration)

Alcohol and Sleeping Pills—A Strange Combination

Psychology Today Addiction Center — Thu, 17 Nov 2011 18:34:34 +0100

Did Ambien make a sleepless paramedic guzzle vodka and drive asleep in his underwear? Primary Topic: Sleep read more (Source: Psychology Today Addiction Center)

ZOLPIDEM TARTRATEtablet, Film Coated [Lake Erie Medica Surgical Supply DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 16 Nov 2011 05:00:00 +0100

Updated Date: Nov 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMBIEN (Zolpidem Tartrate) Tablet [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 16 Nov 2011 05:00:00 +0100

Updated Date: Nov 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Zolpidem withdrawal delirium

Indian Journal of Pharmacology — Mon, 14 Nov 2011 05:00:00 +0100

We report the case of a zolpidem-naive alcohol-dependent inpatient that, while undergoing alcohol de-addiction, was prescribed zolpidem for insomnia and developed delirium during taper-off. He was successfully detoxified for alcohol, treated for delirium and put on disulfiram prophylaxis. The case highlights the need for being cautious while using zolpidem for insomnia in alcohol dependent subjects. (Source: Indian Journal of Pharmacology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Memory disorders associated with consumption of drugs: updating through a case/noncase study in the French PharmacoVigilance Database

British Journal of Clinical Pharmacology — Thu, 10 Nov 2011 07:45:51 +0100

CONCLUSIONS Our study confirmed an association between memory disorders and some drugs, such as benzodiazepines and anticonvulsants. However, other drugs, such as benzodiazepine‐like hypnotics, newer anticonvulsants, serotonin reuptake inhibitor antidepressants, isotretinoin and ciclosporin were significantly associated with memory disorders, although this was not described or poorly described in the literature.Taking account of the limits of this study in the FPVD (under‐reporting, notoriety bias etc.), the case/noncase method allows assessment and detection of associations between exposure to drugs and a specific adverse drug reaction, such as memory disorders, and could thus generate signals and orientate us to further prospective studies to confirm such associations. (Source: Briti...

Potentially Harmful Drug-Drug Interactions in the Elderly: A Review.

The American Journal of Geriatric Pharmacotherapy — Thu, 10 Nov 2011 05:00:00 +0100

CONCLUSIONS: Several population-based studies have reported significant harm associated drug interactions in elderly patients. Increased awareness and interventions aimed at reducing exposure and minimizing the risks associated with potentially harmful drug combinations are needed. PMID: 22078863 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy)

ZOLPIDEM TARTRATEtablet, Film Coated [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 09 Nov 2011 05:00:00 +0100

Updated Date: Nov 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 08 Nov 2011 05:00:00 +0100

Updated Date: Nov 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Medication Use and Functional Status Decline in Older Adults: A Narrative Review.

The American Journal of Geriatric Pharmacotherapy — Fri, 04 Nov 2011 04:00:00 +0100

CONCLUSIONS: Benzodiazepines and anticholinergics have been consistently associated with impairments in functional status in the elderly. The relationships between suboptimal prescribing, antidepressants, and antihypertensives and functional status decline were mixed. Further research using established measures and methods is needed to better describe the impact of medication use on functional status in older adults. PMID: 22057096 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

ZOLPIDEM TARTRATEtablet, Film Coated [Teva Pharmaceuticals USA Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 19 Oct 2011 05:00:00 +0100

Updated Date: Oct 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Zolpidem associated with higher risk of fractures compared to lorazepam and alprazolam, and similar risk to diazepam

NeLM - Mental Health — Wed, 19 Oct 2011 04:00:00 +0100

Source: Journal of the American Geriatrics Society Area: News The Journal of the American Geriatric Society has featured a retrospective cohort study to determine whether zolpidem is a safer alternative to benzodiazepines. The community based study involved patients with an initial prescription for zolpidem (n = 43,343), alprazolam (n = 103,790), lorazepam (n = 150,858), or diazepam (n = 93,618), and rates of non-vertebral fractures and hip fractures requiring hospitalisation were compared before and after an initial prescription for each treatment, adjusting for confounders. The following results were reported: . In patients aged 65 and older, the rates of non-vertebral fractures and dislocations were similar in the pre- treatment intervals. . The rate ratios (RRs) for the ...

Insomnia (primary) in older people

Clinical Evidence — Tue, 11 Oct 2011 23:00:00 +0100

New option(s) added for: Antidepressants New option added. Categorised as Unknown Effectiveness as we found no RCT evidence to assess the effects of this intervention. New evidence; conclusions changed for: CBT New evidence added, categorisation changed (Unknown effectiveness to Beneficial). New evidence; conclusion confirmed for: Exercise programmes New evidence added. Categorisation unchanged (Unknown effectiveness) as there remains insufficient evidence to judge the effects of this intervention. Timed exposure to bright light New evidence added. Categorisation unchanged (Unknown effectiveness) as there remains insufficient evid...

Gender and use of hypnotics or sedatives in old age: a nationwide register-based study

NeLM - Care of Older People — Mon, 10 Oct 2011 04:00:00 +0100

Source: International Journal of Clinical Pharmacy Area: Evidence > Medicines Management > References Objective: To investigate whether gender is associated with use of hypnotics or sedatives and with different types of hypnotics or sedatives in older people after adjustment for age, socioeconomic status (i.e. education) and co-morbidity (i.e. number of other drugs). Setting: Sweden. Method: We conducted a register-based analysis of data on gender, age, dispensed drugs and education from people aged 75-89 years registered in the Swedish Prescribed Drug Register between Jul and Oct 2005 (n = 645,429). Main Outcome Measure: The hypnotic or sedative drug classes were benzodiazepines, benzodiazepine related drugs (i.e. Z-drugs) and other types of hypnotics or sedatives. The indivi...

Effect of Fluvoxamine on the Pharmacokinetics of Zolpidem: A Two-Treatment Period Study in Healthy Volunteers.

Clinical and Experimental Pharmacology and Physiology — Mon, 10 Oct 2011 04:00:00 +0100

Authors: Vlase L, Popa A, Neag M, Muntean D, Achim M, Leucuţa SE Abstract 1 Our objective was to evaluate a possible pharmacokinetic interaction between zolpidem and fluvoxamine in healthy volunteers. 2 The study consisted of 2 periods: Period 1 (Reference), when each volunteer received a single dose of 5 mg zolpidem and Period 2 (Test), when each volunteer received a single dose of 5 mg zolpidem and 100 mg fluvoxamine. Between the two periods, the subjects were treated for 6 days with a single daily dose of 100 mg fluvoxamine. 3 Pharmacokinetic parameters of zolpidem administered in each treatment period were calculated using non-compartmental analysis and the data from two periods were compared to determine statistically significant differences. 4 In the two periods ...

MedWorm Sponsor Message: Find the best January Sales in the UK.

ZOLPIDEM TARTRATEtablet, Film Coated [Cardinal Health]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 29 Sep 2011 05:00:00 +0100

Updated Date: Sep 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 23 Sep 2011 05:00:00 +0100

Updated Date: Sep 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Risk of Fractures Requiring Hospitalization After an Initial Prescription for Zolpidem, Alprazolam, Lorazepam, or Diazepam in Older Adults

Journal of the American Geriatrics Society — Wed, 21 Sep 2011 04:00:00 +0100

ConclusionIn older adults, the risk of injury with zolpidem exceeded that with alprazolam and lorazepam and was similar to that with diazepam. If the associations are causal, then the high incidence of these fractures implies that these treatment induce a substantial number of fractures and consequential costs. Further study of the association is imperative. (Source: Journal of the American Geriatrics Society)

ZOLPIDEM TARTRATEtablet, Extended Release [Sandoz Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 19 Sep 2011 05:00:00 +0100

Updated Date: Sep 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Acute effects of zolpidem extended-release on cognitive performance and sleep in healthy males after repeated nightly use.

Experimental and Clinical Psychopharmacology — Mon, 19 Sep 2011 04:00:00 +0100

The extended-release formulation of zolpidem (Ambien CR) is approved for the treatment of insomnia without a treatment duration limit. Acutely zolpidem impairs performance, and no research to date has examined whether tolerance develops to these performance impairments during nighttime awakening. The present double-blind, placebo-controlled study examined whether tolerance develops to zolpidem-induced acute performance impairment after repeated (22–30 days) nightly use. Effects of bedtime administration of zolpidem extended-release (ZOL; 12.5 mg) were tested on a battery of performance measures assessed during a forced nighttime awakening in 15 healthy male volunteers who completed overnight polysomnographic recording sessions in our laboratory at baseline and after approximately a month...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Transcept Pharmaceuticals Announces Plan to Resubmit Intermezzo New Drug Application Following Meeting with the U.S. Food & Drug Administration

Drugs.com - New Drug Applications — Wed, 14 Sep 2011 22:09:56 +0100

POINT RICHMOND, Calif., Sept. 14, 2011 /PRNewswire/ -- Transcept Pharmaceuticals, Inc. announced today its plan to resubmit to the U.S. Food and Drug Administration (FDA) its New Drug Application (NDA) seeking approval of Intermezzo (zolpidem... (Source: Drugs.com - New Drug Applications)

Mean-field modeling of thalamocortical dynamics and a model-driven approach to EEG analysis [Colloquium Papers (free online)]

Proceedings of the National Academy of Sciences — Tue, 13 Sep 2011 04:00:00 +0100

Higher brain function depends on task-dependent information flow between cortical regions. Converging lines of evidence suggest that interactions between cortical regions and the central thalamus play a key role in establishing the dynamic patterns of functional connectivity that normally support these processes. In patients with chronic disturbances of cognitive function due to severe brain injury, dysfunction of this circuitry likely plays a crucial role in pathogenesis. However, assaying thalamocortical interactions is challenging even in healthy subjects and more so in severely impaired patients. To approach this problem, we apply a dynamical-systems approach to motivate an analysis of the electroencephalogram (EEG). We begin with a model for a single thalamocortical module [Robinson P...

ZOLPIDEM TARTRATEtablet, Film Coated [Qualitest Pharmaceuticals]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 09 Sep 2011 05:00:00 +0100

Updated Date: Sep 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Forebrain medial septum region facilitates nociception in a rat formalin model of inflammatory pain

Pain — Fri, 09 Sep 2011 04:00:00 +0100

Summary: The findings suggest that the medial septum is pro-nociceptive and facilitates central processing of nociceptive information. The region may coordinate cortical and subcortical nociceptive responses.Abstract: The medial septum is anatomically and functionally linked to the hippocampus, a region implicated in nociception. However, the role of medial septum in nociception remains unclear. To investigate the role of the region in nociception in rats, muscimol, a GABA agonist, or zolpidem, a positive allosteric modulator of GABAA receptors, was microinjected into medial septum to attenuate the activity of neurons in the region. Electrophysiological studies in anesthetized rats indicated that muscimol evoked a stronger and longer-lasting suppression of medial septal-mediated activation...

ZOLPIDEM TARTRATEtablet [St Marys Medical Park Pharmacy]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 08 Sep 2011 05:00:00 +0100

Updated Date: Sep 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Find the best January Sales in the UK.

ZOLPIDEM TARTRATE Tablet, Film Coated [Aurobindo Pharma Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 07 Sep 2011 05:00:00 +0100

Updated Date: Sep 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet, Film Coated [Apotex Corp.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 06 Sep 2011 05:00:00 +0100

Updated Date: Sep 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Sleep Eating

Sleep Medicine Clinics — Fri, 02 Sep 2011 04:00:00 +0100

Pathologic sleep eating, known as sleep-related eating disorder (SRED), is characterized by disordered nocturnal eating that arises from sleep. This disruption in the nocturnal fast can result in adverse health consequences such as inadequate sleep maintenance, weight gain, the consumption of inedible substances, or sleep-related injury. The dysfunctional eating may occur in the setting of sedative-hypnotic medications, in particular the widely prescribed benzodiazepine receptor agonists such as zolpidem, frequently inducing amnesia. SRED is often associated with other sleep disorders, in particular restless legs syndrome, and may be a nonmotor manifestation of this condition. (Source: Sleep Medicine Clinics)

ZOLPIDEM TARTRATEtablet [Preferred Pharmaceuticals, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 01 Sep 2011 05:00:00 +0100

Updated Date: Sep 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

F169 antinociception induced by new derivative of zolpidem in neuropathic pain model

European Journal of Pain Supplements — Thu, 01 Sep 2011 04:00:00 +0100

(Source: European Journal of Pain Supplements)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Zolpidem abuse/withdrawal: Dependence followed by various toxicities on withdrawal: 5 case reports

Reactions — Mon, 29 Aug 2011 14:09:06 +0100

(Source: Reactions)

Zolpidem withdrawal: Dependence and withdrawal seizures: case report

Reactions — Mon, 29 Aug 2011 14:09:06 +0100

(Source: Reactions)

Detection and validated quantification of 21 benzodiazepines and 3 “z-drugs” in human hair by LC–MS/MS

Forensic Science International — Mon, 29 Aug 2011 04:00:00 +0100

Abstract: A method for detection and quantification of 21 benzodiazepines and the pharmacologically related “z-drugs” in human hair samples was developed and fully validated using liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS). After methanolic and methanolic/aqueous extraction, the analytes were separated using two different LC–MS systems (AB Sciex 3200 QTRAP and AB Sciex 5500 QTRAP). Separation columns, mobile phases and MS modes for both systems were: Phenomenex Kinetex, 2.6μm, 50/2.1; 5mM ammonium formate buffer pH 3.5/methanol, total flow 0.75mL/min; electrospray ionization (ESI), multiple reaction monitoring (MRM), information dependent acquisition (IDA), enhanced product ion scan (EPI). The assays were found to be selective for the tested compounds (al...

ZOLPIDEM TARTRATEtablet [H.J. Harkins Company, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 26 Aug 2011 05:00:00 +0100

Updated Date: Aug 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 25 Aug 2011 05:00:00 +0100

Updated Date: Aug 25, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Find the best January Sales in the UK.

Sleep driving: Sleepwalking variant or misuse of z-drugs?

Sleep Medicine Reviews — Wed, 17 Aug 2011 20:01:24 +0100

Summary: Sleep driving is most often classified as a variant of sleepwalking, but should be distinguished from impaired driving due to misuse or abuse of sedative/hypnotic drugs. Z-drugs; zolpidem and zopiclone in particular, have been associated with the majority of reported cases of impaired driving. Numerous studies have found z-drugs in driving under influence (DUI) related police stops, arrests and accidents. Impaired drivers are reported to have 1) blood levels of z-drugs that exceed therapeutic ranges 2) failed to take the medication at the correct time or remain in bed for sufficient time and/or 3) combined z-drugs with other central nervous system (CNS) depressants and/or alcohol. Consistent with CNS depression, z-drug-impaired drivers may demonstrate cognitive function at low lev...

Z Drug zombies: Parasomnia, drug effect or both?

Sleep Medicine Reviews — Wed, 17 Aug 2011 20:01:23 +0100

In this issue of SMR Mark Pressman addresses the perplexing problem of sleep driving, particularly as it relates to use of zolpidem and zopiclone. His argument can be summarised into two major points. Firstly, the symptoms of the two conditions sleepwalking sleep driving (i.e., sleep driving as an uncommon variant of the non-REM parasomnia sleepwalking) and Z drug affected driving are qualitatively different phenomena. Secondly, Z drug affected driving appears to occur more commonly than sleepwalking sleep driving, and may be an under-acknowledged public and individual health hazard. The article suggests guidelines, based on current knowledge and informed speculation, which may help to identify and better understand the inherently dangerous activity of driving while under the influence of ...

SENTRAZOLPIDEM PM-5 (Zolpidem Tartrate, Choline) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 15 Aug 2011 05:00:00 +0100

Updated Date: Aug 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GABAZOLPIDEM-5 (Zolpidem Tartrate, Choline) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 15 Aug 2011 05:00:00 +0100

Updated Date: Aug 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet [Major Pharmaceuticals]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 15 Aug 2011 05:00:00 +0100

Updated Date: Aug 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABAA and mGlu receptor subtypes

Psychopharmacology — Thu, 11 Aug 2011 05:55:05 +0100

Conclusions We found that lifelong CRF overproduction is associated with altered gene expression and reduced functional sensitivity of discrete GABAA and mGluR receptor subtypes. These findings suggest that sustained over-activation of cerebral CRF receptors may contribute to the development of altered stress-related behavior via modulation of GABAergic and glutamatergic transmission. Content Type Journal ArticlePages 1-12DOI 10.1007/s00213-011-2423-0Authors Christiaan H. Vinkers, Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Universiteitsweg 99, 3584CG Utrecht, The NetherlandsHendrikus Hendriksen, Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rud...

ZOLPIDEM TARTRATE (Zolpidem Tartrate) Tablet [RedPharm Drug Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 08 Aug 2011 05:00:00 +0100

Updated Date: Aug 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effective reduction of fixed charge densities in germanium based metal-oxide-semiconductor devices

Applied Physics Letters — Thu, 04 Aug 2011 18:46:47 +0100

Shaoren Deng, Qi Xie, Davy Deduytsche, Marc Schaekers, Dennis Lin et al. Metal-oxide-semiconductor capacitor was fabricated using in situ O plasma passivation and subsequent deposition of a HfO high-k gate stack on Ge. By extracting flat band voltages from capacitors with different equivalent oxide thicknesses (EOT), the effect of forming gas annealing (FGA) and O ambien ... [Appl. Phys. Lett. 99, 052906 (2011)] published Wed Aug 3, 2011. (Source: Applied Physics Letters)

Transcept receives CRL from FDA for low-dose zolpidem tartrate formulation

Modern Medicine — Wed, 03 Aug 2011 19:48:06 +0100

FDA has issued a Complete Response Letter (CRL) for Intermezzo (zolpidem tartrate sublingual tablet, Transcept Pharmaceuticals). (Source: Modern Medicine)

ZOLPIDEM TARTRATEtablet, Extended Release [Sandoz Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 01 Aug 2011 05:00:00 +0100

Updated Date: Aug 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Find the best January Sales in the UK.

Brain Effects of General Anesthesia

Psych Central — Tue, 26 Jul 2011 19:49:00 +0100

New research is shedding light on the effects of general anesthesia on the brain and the body. In the United States, nearly 60,000 patients receive general anesthesia for surgery every day. It causes specific patterns of activity in the brain, which can be viewed on an electroencephalogram (EEG). The most common pattern is a gradual rise in low-frequency, high-amplitude activity as the level of anesthesia deepens. Emery Brown, MD, of Massachusetts General Hospital believes, “How anesthetic drugs induce and maintain the behavioral states of general anesthesia is an important question in medicine and neuroscience.” His team investigated general anesthesia versus sleep and coma. They carried out a review of anesthesia studies from a range of areas, including neuroscience and sleep...

Zolpidem abuse: First report of hydrocephalus and meningomyelocele following in utero exposure: case report

Reactions — Sun, 24 Jul 2011 19:59:43 +0100

(Source: Reactions)

Ultra high performance liquid chromatographic-tandem mass spectrometric multi-analyte procedure for target screening and quantification in human blood plasma: validation and application for 31 neuroleptics, 28 benzodiazepines, and Z-drugs.

Analytical and Bioanalytical Chemistry — Wed, 20 Jul 2011 23:00:00 +0100

Authors: Remane D, Meyer MR, Wissenbach DK, Maurer HH For fast and reliable screening, identification, and quantification of as many analytes as possible, multi-analyte approaches are very useful in clinical and forensic toxicology. Using ultra high performance liquid chromatography-tandem mass spectrometry, such an approach has been developed for blood plasma analysis after simple liquid-liquid extraction. In the present paper, validation and application is described for 31 neuroleptics, 28 benzodiazepines, and Z-drugs (zaleplone, zolpidem, and zopiclone). The validation parameters included recovery, matrix effects, process efficiency, ion suppression/enhancement of co-eluting analytes, selectivity, crosstalk, accuracy and precision, stabilities, and limits of quantification and detec...

Transcept Pharmaceuticals Receives Complete Response Letter From FDA On Intermezzo® New Drug Application

Health News from Medical News Today — Sat, 16 Jul 2011 08:00:00 +0100

Transcept Pharmaceuticals, Inc. (Nasdaq: TSPT) announced that it has received a Complete Response Letter from the U.S. Food and Drug Administration (FDA) regarding the resubmitted New Drug Application (NDA) for Intermezzo® (zolpidem tartrate sublingual tablet). In the Complete Response Letter, the FDA confirmed that Transcept has adequately demonstrated that Intermezzo® is efficacious for use as needed in the treatment of insomnia when a middle-of-the-night awakening is followed by difficulty returning to sleep... (Source: Health News from Medical News Today)

ZOLPIDEM TARTRATEtablet, Film Coated [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 15 Jul 2011 05:00:00 +0100

Updated Date: Jul 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

AMBIEN CR (Zolpidem Tartrate) Tablet, Coated [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 14 Jul 2011 05:00:00 +0100

Updated Date: Jul 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FDA Questions Insomnia Drug AgainFDA Questions Insomnia Drug Again

Medscape Today Headlines — Wed, 13 Jul 2011 22:44:22 +0100

Trancept Pharmaceuticals is reporting that the US Food and Drug Administration (FDA) is rejecting its new formulation of zolpidem tartrate for a second time. Medscape Medical News (Source: Medscape Today Headlines)

Hair analysis of drugs involved in drug-facilitated sexual assault and detection of zolpidem in a suspected case

International Journal of Legal Medicine — Wed, 13 Jul 2011 06:12:21 +0100

Abstract In drug-facilitated crimes, victims are subjected to nonconsensual acts while they are incapacitated by the effects of a drug. A specific LC-MS/MS protocol for determining benzodiazepines and hypnotics at low concentration in hair specimens was developed and validated in order to target the allegedly administered drugs on a chronological basis. In the case hereby reported, a 26-year-old woman claimed to have been sexually assaulted after being administered an allegedly drugged coffee, but toxicological analysis of urine and blood provided no evidence of any drug intake. Subsequently, a second woman accused the same man of sexual abuse. Hence, the suspect was prosecuted. Specimens were collected from four subjects (two alleged victims, the suspect and his wife) and...

ZOLPIDEM TARTRATEtablet [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 13 Jul 2011 05:00:00 +0100

Updated Date: Jul 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Changes of structure and dipole moment of water with temperature and pressure: A first principles study

Journal of Chemical Physics — Tue, 12 Jul 2011 21:33:44 +0100

Dongdong Kang, Jiayu Dai, and Jianmin Yuan The changes of structure and distribution of dipole moment of water with temperatures up to 2800 K and densities up to 2.2 g/cm are investigated using ab initio molecular dynamics. Along the isochore of 1.0 g/cm, the structure of liquid water above 800 K is dramatically different from that at ambien ... [J. Chem. Phys. 135, 024505 (2011)] published Tue Jul 12, 2011. (Source: Journal of Chemical Physics)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Transcept Pharmaceuticals Expects Complete Response Letter On Intermezzo® New Drug Application Based On Teleconference With FDA

Pharmaceutical Online News — Tue, 12 Jul 2011 05:44:00 +0100

Transcept Pharmaceuticals, Inc. (Nasdaq: TSPT) announced today that it expects to receive a Complete Response Letter from the U.S. Food and Drug Administration (FDA) regarding the resubmitted New Drug Application (NDA) for Intermezzo® (zolpidem tartrate sublingual tablet) on or before July 14, 2011, the PDUFA date assigned by the FDA for completion of the Intermezzo® NDA review. (Source: Pharmaceutical Online News)

Discriminative stimulus properties of GABA(A) receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem.

European Journal of Pharmacology — Thu, 07 Jul 2011 23:00:00 +0100

Authors: Vinkers CH, Olivier B, Hanania T, Min W, Schreiber R, Hopkins SC, Campbell U, Paterson N There is increased understanding that distinct GABA(A) receptor subtypes mediate different effects of classical benzodiazepines. Here, we aimed to define the contributions of α(1)-containing subtypes of the subtype-selective GABA(A) receptor positive allosteric modulators TPA023, ocinaplon, and NG2-73 using drug discrimination. We characterized these compounds with defined subunit preferences in rats that were trained to discriminate either the non-selective benzodiazepine chlordiazepoxide (CDP, 5.0mg/kg) or the α(1)-selective drug zolpidem (1.5mg/kg). In short, CDP but not zolpidem generalized to the CDP cue. In contrast, zolpidem-trained rats showed opposite effects and generalized to ...

ZOLPIDEM TARTRATEtablet [Golden State Medical Supply, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 07 Jul 2011 05:00:00 +0100

Updated Date: Jul 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Sleep disturbance and the effects of extended-release zolpidem during cannabis withdrawal

Drug and Alcohol Dependence — Thu, 30 Jun 2011 17:03:21 +0100

Conclusions: These data extend prior research that indicates abrupt abstinence from cannabis can lead to clinically significant sleep disruption in daily users. The findings also indicate that sleep disruption associated with cannabis withdrawal can be attenuated by zolpidem, suggesting that hypnotic medications might be useful adjunct pharmacotherapies in the treatment of cannabis use disorders. (Source: Drug and Alcohol Dependence)

Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique

Clinical and Developmental Immunology — Mon, 27 Jun 2011 15:55:56 +0100

The present investigation describes the influence of the concentration of PEG 6000 as a melt binder and ratio of HPMC K4M : PVP on Zolpidem tartrate controlled-release tablet formulations using 32 full factorial design. The ratio of HPMC K4M and PVP K30 (X1) and the concentration of melt binder (X2) were selected as independent variables, and drug release at 1 hr (Q1), 4 hr (Q4), 8 hr (Q8), diffusion coefficient (n), and release rate constant (K) were selected as a dependent variable. Tablets were prepared by melt granulation technique and evaluated for various evaluation parameters. It was observed that concentration of melt binder had significant effect on Q1, Q4, n, and K Binder concentration 25% w/w was found optimum. Optimized formulation ...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Benefit of cognitive-behavior therapy alongside pharmacotherapy in treating obsessive-compulsive disorder with depression: a case report and review of the literature

International Journal of Students Research — Mon, 27 Jun 2011 06:03:55 +0100

We present a challenging case highlighting the benefit of CBT alongside medication adjustments in a mental health unit. A 20-year-old male patient presented to our mental health unit with previously diagnosed OCD and severe depression. In addition, he also had social anxiety, insomnia, and suicidal ideation. Patient history revealed that he had been prescribed fluvoxamine, 200 mg per day, five months back but his symptoms had gotten worse. He has had one previous hospitalization. His Global Assessment of Functioning (GAF) at admission was in the range of 21-30. The fluvoxamine that had been previously prescribed was kept at 200 mg per day. In addition, he was also prescribed lorazepam 1 mg every four hours (anxiety), and zolpidem 10 mg per day (insomnia). During his inpatient stay, the pat...

Fast network oscillations in vitro exhibit a slow decay of temporal auto‐correlations

European Journal of Neuroscience — Mon, 20 Jun 2011 23:00:00 +0100

AbstractOngoing neuronal oscillations in vivo exhibit non‐random amplitude fluctuations as reflected in a slow decay of temporal auto‐correlations that persist for tens of seconds. Interestingly, the decay of auto‐correlations is altered in several brain‐related disorders, including epilepsy, depression and Alzheimer’s disease, suggesting that the temporal structure of oscillations depends on intact neuronal networks in the brain. Whether structured amplitude modulation occurs only in the intact brain or whether isolated neuronal networks can also give rise to amplitude modulation with a slow decay is not known. Here, we examined the temporal structure of cholinergic fast network oscillations in acute hippocampal slices. For the first time, we show that a slow decay of temporal...

Zolpidem abuse: Withdrawal seizures after dependence: 2 case reports

Reactions — Sat, 18 Jun 2011 16:44:29 +0100

(Source: Reactions)

ZOLPIDEM TARTRATEtablet, Film Coated, Extended Release [Actavis Elizabeth LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 17 Jun 2011 05:00:00 +0100

Updated Date: Jun 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMBIEN CR (Zolpidem Tartrate) Tablet, Coated [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 13 Jun 2011 05:00:00 +0100

Updated Date: Jun 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Find the best January Sales in the UK.

Serotonin control of sleep-wake behavior

Sleep Medicine Reviews — Sat, 11 Jun 2011 03:59:37 +0100

Summary: Based on electrophysiological, neurochemical, genetic and neuropharmacological approaches, it is currently accepted that serotonin (5-HT) functions predominantly to promote wakefulness (W) and to inhibit REM (rapid eye movement) sleep (REMS). Yet, under certain circumstances the neurotransmitter contributes to the increase in sleep propensity. Most of the serotonergic innervation of the cerebral cortex, amygdala, basal forebrain (BFB), thalamus, preoptic and hypothalamic areas, raphe nuclei, locus coeruleus and pontine reticular formation comes from the dorsal raphe nucleus (DRN). The 5-HT receptors can be classified into at least seven classes, designated 5-HT1–7. The 5-HT1A and 5-HT1B receptor subtypes are linked to the inhibition of adenylate cyclase, and their activation evo...

ZOLPIDEM TARTRATEtablet [RedPharm Drug Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 08 Jun 2011 05:00:00 +0100

Updated Date: Jun 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Akathisia Induced by Gabapentin Withdrawal (June).

The Annals of Pharmacotherapy — Mon, 06 Jun 2011 23:00:00 +0100

CONCLUSIONS If gabapentin discontinuation is desired, it is prudent to gradually taper the dose to avoid withdrawal symptoms, which may occur after as little as 1 month of treatment. Should the patient experience withdrawal symptoms, the optimal treatment is to restart gabapentin. PMID: 21652784 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Zolpidem: Sleep-related eating disorders: 8 case reports

Reactions — Sun, 05 Jun 2011 19:54:23 +0100

(Source: Reactions)

18 U.S. veterans commit suicide daily; largely due to psychiatric drugs

NaturalNews.com — Fri, 03 Jun 2011 07:00:00 +0100

(NaturalNews) "If mentally incapacitated troops are being drugged with dangerous, mind-altering drugs and deployed to battle against their will, how can we say that we have a volunteer army?" asked Alliance for Human Research Protection, the national network dedicated to advancing responsible and ethical medical research practices.This is just one of the many criticisms being levied against the U.S. military in light of its liberal use of prescription medication, which is now being linked to rising suicide rates among soldiers.A study released by the Army in June 2009 indicated that nearly as many American troops at home and abroad committed suicide in the first six months of 2006 as the number who had been killed in combat in Afghanistan during the same time period (http://www.npr.org/tem...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

ZOLPIDEM TARTRATEtablet [Cardinal Health]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 03 Jun 2011 05:00:00 +0100

Updated Date: Jun 3, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet, Film Coated [RedPharm Drug Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 03 Jun 2011 05:00:00 +0100

Updated Date: Jun 3, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet, Film Coated [McKesson Packaging Services Business Unit Of McKesson Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Jun 2011 05:00:00 +0100

Updated Date: Jun 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 27 May 2011 05:00:00 +0100

Updated Date: May 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet, Film Coated [RedPharm Drug, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 20 May 2011 05:00:00 +0100

Updated Date: May 20, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Find the best January Sales in the UK.

Actions of two GABA(A) receptor benzodiazepine-site ligands that are mediated via non-γ2-dependent modulation.

European Journal of Pharmacology — Wed, 18 May 2011 23:00:00 +0100

Authors: Leppä E, Linden AM, Rabe H, Vekovischeva OY, Wulff P, Lüddens H, Wisden W, Korpi ER The potent sedative-hypnotic zolpidem and the convulsant methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate (DMCM) act primarily by binding to the benzodiazepine site of the main inhibitory neurotransmitter receptor, the pentameric γ-aminobutyric acid type A receptor (GABA(A)). This binding depends critically on the wild-type F77 residue of the GABA(A) receptor γ2 subunit. Mice with γ2 subunit F77I point mutation (γ2I77 mouse line) lose the high-affinity nanomolar binding of these ligands as well as their most robust behavioral actions at low doses. Interestingly, the γ2I77 mice offer a tool to study the actions of these substances mediated via other possible binding sites of the GA...

Desensitization of GABAergic receptors as a mechanism of zolpidem-induced somnambulism

Medical Hypotheses — Wed, 11 May 2011 23:00:00 +0100

Abstract: Sleepwalking is a frequently reported side effect of zolpidem which is a short-acting hypnotic drug potentiating activity of GABAA receptors. Paradoxically, the most commonly used medications for somnambulism are benzodiazepines, especially clonazepam, which also potentiate activity of GABAA receptors. It is proposed that zolpidem-induced sleepwalking can be explained by the desensitization of GABAergic receptors located on serotonergic neurons. According to the proposed model, the delay between desensitization of GABA receptors and a compensatory decrease in serotonin release constitutes the time window for parasomnias. The occurrence of sleepwalking depends on individual differences in receptor desensitization, autoregulation of serotonin release and drug pharmacokinetics. The ...

FTC Says Firms Failed to Report Drug Patent Pact

WSJ.com: Health — Tue, 10 May 2011 16:33:51 +0100

The Federal Trade Commission notified a trio of drug makers it believes their failure to inform antitrust authorities of patent infringement deals involving Sanofi's Ambien CR was illegal. (Source: WSJ.com: Health)

Memory disorders associated with drugs consumption: updating through a case / non‐case study in the French PharmacoVigilance Database

British Journal of Clinical Pharmacology — Mon, 09 May 2011 23:00:00 +0100

Conclusions Our study confirmed an association between memory disorders and some drugs like benzodiazepines or anticonvulsants. But other drugs like hypnotics “benzodiazepines‐like”, newer anticonvulsants, SRI antidepressants, isotretinoin and cyclosporine were significantly associated with memory disorders although it was not or poorly described in literature.Taking account of limits of this study in the FPVD (under‐reporting, notoriety bias …), the case/non‐case method allows to assess and detect associations between drugs exposure and a specific adverse drug reaction such as memory disorders, and could thus generate signals and orientate us to further prospective studies to confirm such associations. (Source: British Journal of Clinical Pharmacology)

Neurotransmitters in disorders of consciousness and brain damage

Medical Hypotheses — Sun, 08 May 2011 23:00:00 +0100

Abstract: Restorations from disorders of consciousness such as the minimally conscious state and the vegetative state have been achieved spontaneously or by pharmacological agents such as zolpidem, baclofen, dopaminergic agents and tricyclic antidepressants in some patients. Other restoration methods have included electric and magnetic nerve stimulation, oxygen, Kreb’s cycle constituent substitution and axonal re-growth. Although apparently unrelated, these methods all influence neurotransmitter availability or production within the brain. This review proposes depleted neurotransmitter function as a cause for long term brain suppression and disorders of consciousness. It unifies fundamentally different treatment approaches and explores the restoration of neurotransmitter function as a co...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

SENTRAZOLPIDEM PM-5 (Zolpidem, Choline) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 06 May 2011 05:00:00 +0100

Updated Date: May 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

GABAZOLPIDEM-5 (Zolpidem, Choline) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 06 May 2011 05:00:00 +0100

Updated Date: May 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Increased Estradiol and Improved Sleep, But Not Hot Flashes, Predict Enhanced Mood during the Menopausal Transition.

The Journal of Clinical Endocrinology and Metabolism — Tue, 26 Apr 2011 23:00:00 +0100

Conclusions: For women with menopause-associated depression, improvement in depression is predicted by improved sleep, and among perimenopausal women, by increasing estradiol levels. These results suggest that changes in estradiol and sleep quality, rather than hot flashes, mediate depression during the menopause transition. Therapies targeting insomnia may be valuable in treating menopause-associated depression. PMID: 21525161 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

ZOLPIDEM TARTRATEtablet, Film Coated [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 19 Apr 2011 05:00:00 +0100

Updated Date: Apr 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Spontaneous adverse event reports associated with zolpidem in Australia 2001-2008.

Journal of Sleep Research — Sun, 10 Apr 2011 23:00:00 +0100

Authors: Ben-Hamou M, Marshall NS, Grunstein RR, Saini B, Fois RA A prominent media publicity cluster during 2007-2008 in Australia linked the common hypnotic zolpidem to adverse drug reaction reports of parasomnias, amnesia, hallucinations and suicidality. The collection of adverse drug reaction data through spontaneous reporting systems is a mainstay of drug safety monitoring, but a stimulated reporting event such as this often renders such data uninterpretable. As such, we aimed to investigate whether these associations were present before the media cluster and then to quantify the effect of stimulated reporting on those four specific outcomes. Using disproportionality analyses we compared zolpidem to all other drugs in the database, and then separately to each of all hypnotics, the...

MedWorm Sponsor Message: Find the best January Sales in the UK.

ZOLPIDEM (Zolpidem Tartrate) Tablet [West-Ward Pharmaceutical Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 08 Apr 2011 05:00:00 +0100

Updated Date: Apr 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pharmacological Advances in the Treatment of Insomnia.

Current Pharmaceutical Design — Thu, 07 Apr 2011 23:00:00 +0100

Authors: Richey SM, Krystal AD Insomnia is a highly prevalent condition, and due to ongoing demand from patients suffering with this condition, new pharmacological treatments are actively being sought. As our neurophysiological understanding of insomnia grows, so too do the available treatment options. A significant advance in the treatment of insomnia came with the development of the nonbenzodiazepine hypnotic medications, zolpidem, zaleplon and eszopiclone. These medications have shorter durations of action than many traditional benzodiazepines and may be associated with less risk of tolerance and abuse. They have also been demonstrated to be helpful in cases in which insomnia is comorbid with depression or anxiety, leading to beneficial effects not only with sleep but also with mood...

The First Line of Treatment for Insomnia That’ll Surprise You

Psych Central — Wed, 30 Mar 2011 16:31:19 +0100

Whenever most people have serious trouble sleeping, they automatically reach for a sleeping aid, whether that’s a prescription or over-the-counter medication or a natural remedy. But these solutions, as psychologist and sleep specialist Stephanie Silberman, Ph.D, explained, are anything but. In fact, the preferred solution — the one that research also supports — is a treatment that many people, even medical professionals, are unaware of. Research has shown that cognitive-behavioral therapy (CBT) is highly effective for insomnia. (Effective results have been shown in a recent meta-analysis and article review.) Below, Dr. Silberman, author of The Insomnia Workbook: A Comprehensive Guide to Getting the Sleep You Need, offers insight into insomnia and its treatment and shares s...

ZOLPIDEM TARTRATEtablet [Carlsbad Technology, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 25 Mar 2011 05:00:00 +0100

Updated Date: Mar 25, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Medical Minute: Ambien Side Effects

Wed, 23 Mar 2011 18:40:14 +0100

WBZ's Dr. Murray Feingold talks about the drug Ambien. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Fluvoxamine/zolpidem: Hallucinations and sleepwalking in adolescents: case report

Reactions — Tue, 22 Mar 2011 17:01:08 +0100

(Source: Reactions)

AMBIEN CR (Zolpidem Tartrate) Tablet, Coated [Sanofi-Aventis U.S. LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 18 Mar 2011 05:00:00 +0100

Updated Date: Mar 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMBIEN (Zolpidem Tartrate) Tablet, Film Coated [Sanofi-Aventis U.S. LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 18 Mar 2011 05:00:00 +0100

Updated Date: Mar 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Evaluation of the Abuse Potential of Lorcaserin, a Serotonin 2C (5-HT(2C)) Receptor Agonist, in Recreational Polydrug Users.

Clinical Pharmacology and Therapeutics — Wed, 16 Mar 2011 00:00:00 +0100

This study assessed the drug's abuse potential on the basis of its pharmacological profile. For this purpose, a double-blind, double-dummy, placebo-controlled, randomized seven-way crossover study with single oral doses of lorcaserin (20, 40, and 60 mg), zolpidem (15 and 30 mg), ketamine (100 mg), and placebo was conducted in recreational polydrug users (N = 35). Subjective and objective measures were assessed up to 24 h after the dose. We found that zolpidem and ketamine had significantly higher peak scores relative to placebo on the primary measures as well as on most of the secondary measures. The subjective effects of a 20-mg dose of lorcaserin were similar to those of placebo, whereas supratherapeutic doses of lorcaserin were associated with significant levels of dislike by users ...

ZOLPIDEM TARTRATEtablet [Carlsbad Technology, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 15 Mar 2011 05:00:00 +0100

Updated Date: Mar 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Find the best January Sales in the UK.

Sleep driving: Sleepwalking variant or misuse of z-drugs? - Pressman MR.

SafetyLit: All (Unduplicated) — Mon, 14 Mar 2011 01:17:43 +0100

Sleep driving is most often classified as a variant of sleepwalking, but should be distinguished from impaired driving due to misuse or abuse of sedative/hypnotic drugs. Z-drugs; zolpidem and zopiclone in particular, have been associated with the majority ... (Source: SafetyLit: All (Unduplicated))

ZOLPIDEM TARTRATEtablet, Film Coated [Southeast Medical Solutions RX LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 10 Mar 2011 05:00:00 +0100

Updated Date: Mar 10, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet, Film Coated [Aurobindo Pharma Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 08 Mar 2011 05:00:00 +0100

Updated Date: Mar 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet, Film Coated [NorthStar Rx LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 07 Mar 2011 05:00:00 +0100

Updated Date: Mar 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

IFN-α-2a (Interferon) and ribavirin induced suicidal attempt in a patient of chronic HCV: A rare case report

Indian Journal of Pharmacology — Sun, 06 Mar 2011 00:00:00 +0100

We present a case report of depression induced by IFN-α and ribavirin, leading to attempted suicide. Following the episode, antidepressant paroxetine (20 mg o.d.) and zolpidem (10 mg h.s) were added with psychotherapy. No significant improvement was observed. Patient was given a drug dechallenge (IFN-α and ribavirin). Dramatic improvement was seen over 1 month. Following rechallenge with combination, patient again experienced depressive symptoms with suicidal ideation. IFN-α and ribavirin were promptly stopped. Naranjo causality assessment scale revealed probable association with IFN-α and ribavirin. The report intends to improve awareness among clinicians to facilitate early diagnosis and intervention of similar cases. (Source: Indian Journa...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Benzodiazepine-Like Hypnotics and the Associated Risk of Road Traffic Accidents.

Clinical Pharmacology and Therapeutics — Wed, 02 Mar 2011 00:00:00 +0100

Authors: Orriols L, Philip P, Moore N, Castot A, Gadegbeku B, Delorme B, Mallaret M, Lagarde E The aim of the study was to investigate the association between the use of benzodiazepine or benzodiazepine-like hypnotics and the risk of road traffic accidents. Data from three French national databases were matched: the health-care insurance database, police reports, and the police database of injury-related traffic accidents. A total of 72,685 drivers involved in injury-related road traffic accidents in France, from 2005 to 2008, were included in the study. The risk of being responsible for a traffic accident was higher in users of benzodiazepine hypnotics (odds ratio (OR) = 1.39 (1.08-1.79)) and in the 155 drivers to whom a dosage of more than one pill of zolpidem a day had been dispense...

Spontaneous adverse event reports associated with zolpidem in Australia 2001–2008

Journal of Sleep Research — Tue, 01 Mar 2011 00:00:00 +0100

SummaryA prominent media publicity cluster during 2007–2008 in Australia linked the common hypnotic zolpidem to adverse drug reaction reports of parasomnias, amnesia, hallucinations and suicidality. The collection of adverse drug reaction data through spontaneous reporting systems is a mainstay of drug safety monitoring, but a stimulated reporting event such as this often renders such data uninterpretable. As such, we aimed to investigate whether these associations were present before the media cluster and then to quantify the effect of stimulated reporting on those four specific outcomes. Using disproportionality analyses we compared zolpidem to all other drugs in the database, and then separately to each of all hypnotics, then all benzodiazepines, and then temazepam alone, and did so i...

SENTRAZOLPIDEM PM-5 (Zolpidem, Choline) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 28 Feb 2011 05:00:00 +0100

Updated Date: Feb 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZOLPIDEM TARTRATEtablet, Film Coated, Extended Release [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 28 Feb 2011 05:00:00 +0100

Updated Date: Feb 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm: Ambien

Zolpidem: Nocturnal sleep-related eating disorder: case report

Zolpidem: Somnambulism in an elderly patient: case report

Zolpidem: Sleep driving: case report

Zolpidem withdrawal: Delirium: case report

ZOLPIDEM TARTRATE EXTENDED RELEASE (Zolpidem Tartrate) Tablet, Film Coated, Extended Release [Par Pharmaceutical, Inc.]

New Sleeping Pill: Intermezzo May Help You Get Back to Sleep

AMBIEN CR (Zolpidem Tartrate) Tablet, Coated [PD-Rx Pharmaceuticals, Inc.]

Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia

ZOLPIDEM TARTRATEtablet [STAT RX USA LLC]

ZOLPIDEM TARTRATEtablet, Film Coated [Roxane Laboratories, Inc]

zolpidem, Intermezzo

The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses

Effects of GF-015535-00, a Novel α1 GABAA Receptor Ligand, on the Sleep-Wake Cycle in Mice, with Reference to Zolpidem

Zolpidem ingestion, automatisms, and sleep driving: a clinical and legal case series. - Poceta JS.

ZOLPIDEM TARTRATEtablet, Film Coated [Lake Erie Medical DBA Quality Care Products LLC]

ZOLPIDEM TARTRATEtablet, Film Coated [McKesson Contract Packaging]

Benzodiazepine use in Belgian nursing homes: a closer look into indications and dosages

What Role Will Intermezzo® Play in Treating Insomnia?What Role Will Intermezzo® Play in Treating Insomnia?

ZOLPIDEM TARTRATEtablet, Film Coated, Extended Release [American Health Packaging]

Zolpidem Ingestion, Automatisms, and Sleep Driving: A Clinical and Legal Case Series

Molecules, Money, and Ambien Awakenings

AMBIEN CR (Zolpidem Tartrate) Tablet, Coated [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC]

Table of Contents

Intermezzo (Zolpidem Tartrate) - updated on RxList

Psychopharmacology of REM Sleep and Dreams

Ambien May Wake Some from Minimally Conscious State

MSLT in Primary Insomnia: Stability and Relation to Nocturnal Sleep

FDA Approves First Insomnia Drug for Middle-of-the-night Waking

Can Ambien Wake the Near-Dead?

Sleep aid toxicosis in dogs: 317 cases (2004–2010)

Monthly Roundup - November 2011

Tell us about your drug use - legal and otherwise

FDA approves first drug to treat specific type of insomnia

FDA approves Intermezzo sublingual tablet for insomnia

Drug treats middle-of-the-night insomnia

FDA Approves First Insomnia Drug For Middle-of-the-Night Waking Followed By Difficulty Returning To Sleep

US FDA approves zolpidem tartrate (Intermezzo) for middle-of-the-night waking followed by difficulty returning to sleep

FDA Approves First Insomnia Drug For Middle-of-the-Night Waking

Low-Dose Zolpidem Gets FDA Okay for Wee-Hours Awakening

FDA Approves Intermezzo for Middle-of-the-Night Waking Followed by Difficulty Returning to Sleep

FDA Approves Intermezzo, First Drug for Early WakeningFDA Approves Intermezzo, First Drug for Early Wakening

FDA approves first insomnia drug for middle-of-the-night waking followed by difficulty returning to sleep

Alcohol and Sleeping Pills—A Strange Combination

ZOLPIDEM TARTRATEtablet, Film Coated [Lake Erie Medica Surgical Supply DBA Quality Care Products LLC]

AMBIEN (Zolpidem Tartrate) Tablet [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC]

Zolpidem withdrawal delirium

Memory disorders associated with consumption of drugs: updating through a case/noncase study in the French PharmacoVigilance Database

Potentially Harmful Drug-Drug Interactions in the Elderly: A Review.

ZOLPIDEM TARTRATEtablet, Film Coated [Lake Erie Medical DBA Quality Care Products LLC]

ZOLPIDEM TARTRATEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

Medication Use and Functional Status Decline in Older Adults: A Narrative Review.

ZOLPIDEM TARTRATEtablet, Film Coated [Teva Pharmaceuticals USA Inc]

Zolpidem associated with higher risk of fractures compared to lorazepam and alprazolam, and similar risk to diazepam

Insomnia (primary) in older people

Gender and use of hypnotics or sedatives in old age: a nationwide register-based study

Effect of Fluvoxamine on the Pharmacokinetics of Zolpidem: A Two-Treatment Period Study in Healthy Volunteers.

ZOLPIDEM TARTRATEtablet, Film Coated [Cardinal Health]

ZOLPIDEM TARTRATEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

Risk of Fractures Requiring Hospitalization After an Initial Prescription for Zolpidem, Alprazolam, Lorazepam, or Diazepam in Older Adults

ZOLPIDEM TARTRATEtablet, Extended Release [Sandoz Inc]

Acute effects of zolpidem extended-release on cognitive performance and sleep in healthy males after repeated nightly use.

Transcept Pharmaceuticals Announces Plan to Resubmit Intermezzo New Drug Application Following Meeting with the U.S. Food & Drug Administration

Mean-field modeling of thalamocortical dynamics and a model-driven approach to EEG analysis [Colloquium Papers (free online)]

ZOLPIDEM TARTRATEtablet, Film Coated [Qualitest Pharmaceuticals]

Forebrain medial septum region facilitates nociception in a rat formalin model of inflammatory pain

ZOLPIDEM TARTRATEtablet [St Marys Medical Park Pharmacy]

ZOLPIDEM TARTRATE Tablet, Film Coated [Aurobindo Pharma Limited]

ZOLPIDEM TARTRATEtablet, Film Coated [Apotex Corp.]

Sleep Eating

ZOLPIDEM TARTRATEtablet [Preferred Pharmaceuticals, Inc]

F169 antinociception induced by new derivative of zolpidem in neuropathic pain model

Zolpidem abuse/withdrawal: Dependence followed by various toxicities on withdrawal: 5 case reports

Zolpidem withdrawal: Dependence and withdrawal seizures: case report

Detection and validated quantification of 21 benzodiazepines and 3 “z-drugs” in human hair by LC–MS/MS

ZOLPIDEM TARTRATEtablet [H.J. Harkins Company, Inc.]

ZOLPIDEM TARTRATEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

Sleep driving: Sleepwalking variant or misuse of z-drugs?

Z Drug zombies: Parasomnia, drug effect or both?

SENTRAZOLPIDEM PM-5 (Zolpidem Tartrate, Choline) Kit [Physician Therapeutics LLC]