MedWorm: Amiodarone

Amiodarone/grapefruit interaction: Bradycardia and ventricular arrhythmia in an elderly patient: case report

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Amiodarone: Monomorphic ventricular tachycardia: case report

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Amiodarone: Anaphylaxis: case report

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Amiodarone: Thyrotoxicosis in an elderly patient: case report

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AMIODARONE HYDROCHLORIDEinjection, Solution [APP Pharmaceuticals, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 02 Feb 2012 05:00:00 +0100

Updated Date: Feb 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Amiodarone After Lung Surgery Cuts Afib (CME/CE)

MedPage Today State Required CME — Tue, 31 Jan 2012 00:43:12 +0100

FT. LAUDERDALE (MedPage Today) -- Postoperative administration of amiodarone after lung cancer resection significantly reduced the risk of atrial fibrillation in a randomized trial. (Source: MedPage Today State Required CME)

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PACERONE (Amiodarone Hydrochloride) Tablet [Cardinal Health]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 27 Jan 2012 05:00:00 +0100

Updated Date: Jan 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

NIH launches trials to evaluate CPR and drugs after sudden cardiac arrest

National Institutes of Health (NIH) News Releases — Thu, 26 Jan 2012 17:36:00 +0100

The National Institutes of Health has launched two multi-site clinical trials to evaluate treatments for out-of-hospital cardiac arrest. One will compare continuous chest compressions (CCC) combined with pause- free rescue breathing to standard cardiopulmonary resuscitation (CPR), which includes a combination of chest compressions and pauses for rescue breathing. The other trial will compare treatment with the drug amiodarone, another drug called lidocaine, or neither medication (a salt-water placebo) in participants with shock-resistant ventricular fibrillation, a condition in which the heart beats chaotically instead of pumping blood. (Source: National Institutes of Health (NIH) News Releases)

Management of postoperative atrial fibrillation

Journal of Anesthesia — Tue, 24 Jan 2012 18:14:08 +0100

Abstract The impact of postoperative atrial fibrillation (PAF) on patient outcomes has prompted intense investigation into the optimal methods for prevention and treatment of this complication. In the prevention of PAF, β-blockers and amiodarone are particularly effective and are recommended by guidelines. However, their use requires caution due to the possibility of drug-related adverse effects. Aside from these risks, perioperative prophylactic treatment with statins seems to be effective for preventing PAF and is associated with a low incidence of adverse effects. PAF can be treated by rhythm control, heart-rate control, and antithrombotic therapy. For the purpose of heart rate control, β-blockers, calcium-channel antagonists, and amiodarone are used. In patients with...

Amiodarone: Facial hyperpigmentation: case report

Reactions — Mon, 23 Jan 2012 18:35:21 +0100

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Amiodarone: Liver injury in an elderly patient: case report

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AMIODARONE HYDROCHLORIDEtablet [Taro Pharmaceuticals U.S.A., Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 23 Jan 2012 05:00:00 +0100

Updated Date: Jan 23, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Outpatient evaluation and management of patients with ventricular premature beats or non-sustained ventricular tachycardia

Europace — Fri, 20 Jan 2012 05:00:00 +0100

In this survey, European physicians who deal with arrhythmia patients gave their opinions about diagnostic work up when they see patients with ventricular premature beats (VPBs) or non-sustained ventricular tachycardia (NSVT). In general, similar work-up regimens were used for these two arrhythmias except for coronary angiography, which was considered by one in four physicians when dealing with NSVT but by almost none for VPBs. The majority of physicians believe that it is acceptable to abstain from pharmacological therapy in an asymptomatic patient with VPBs. When considering second-line therapy almost half of the respondents would consider amiodarone in patients with NSVT whereas almost none would when dealing with VPBs. When the effect of therapy was evaluated, its influence on symptoms...

NEXTERONE (Amiodarone Hydrochloride) Injection, Solution [Baxter Healthcare Corporation]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 18 Jan 2012 05:00:00 +0100

Updated Date: Jan 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Amiodarone: Thyroid storm in an elderly patient, treated with levocarnitine: case report

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Amiodarone: Exanthema and photosensitivity in an elderly patient: case report

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A Rare Case of Acute Diffuse Alveolar Hemorrhage Following Initiation of Amiodarone: A Case Report

Military Medicine — Sat, 14 Jan 2012 23:37:51 +0100

(Source: Military Medicine)

Amiodarone: Dyslipidaemia and hypothyroidism: case report

Reactions — Fri, 13 Jan 2012 23:22:43 +0100

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Effects of a novel amiodarone-like compound SAR114646A on the pig atrium and susceptibility to ventricular fibrillation in dogs and pigs

Naunyn-Schmiedeberg's Archives of Pharmacology — Tue, 10 Jan 2012 16:59:48 +0100

This study evaluated the antiarrhythmic efficacy of this drug in vivo. In porcine studies, atrial effective refractory period (AERP) was measured in pentobarbital-anesthetized thoracotomized pigs and atrial fibrillation (AF) was induced by a premature beat. Ventricular fibrillation (VF) was induced via either burst pacing or programmed electrical stimulation (a series of progressively shorter beats, S1–S5). In canine studies, VF was induced by a 2-min occlusion of the left circumflex coronary artery during the last minute of exercise in dogs with healed myocardial infarctions (n = 8). One week later, this test was repeated after pretreatment with SAR114646A (3.0 mg/kg, i.v., slow bolus). SAR114646A produced a significant dose-dependent prolongation of AERP, inhibited AF induced ...

AMIODARONE HYDROCHLORIDEtablet [Eon Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 10 Jan 2012 05:00:00 +0100

Updated Date: Jan 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effect of Amiodarone on Dispersion of Ventricular Repolarization in a Canine Congestive Heart Failure Model.

Clinical and Experimental Pharmacology and Physiology — Mon, 09 Jan 2012 05:00:00 +0100

Authors: Zhou SX, Fang C, Zheng SX, Zhang YL, Lei J, Wang JF Abstract 1. The effects of amiodarone on ventricular electrophysiological parameters, especially the dispersion of ventricular repolarization, were investigated in a canine model of congestive heart failure (CHF). 2. Dogs were randomized to either a control, amiodarone, CHF, or CHF + amiodarone group. Dogs in the CHF and CHF + amiodarone groups underwent 4-5 weeks of rapid ventricular pacing; dogs in the control and amiodarone groups underwent only a sham operation. Amiodarone 20mg/kg/day was administered orally beginning on day 1 post-operatively in the treatment groups, and ventricular electrophysiological variables were evaluated 4-5 weeks after rapid pacing or sham operation. 3. In CHF dogs, the transmural dispe...

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Nexterone (Amiodarone HCl Injection) - updated on RxList

RxList - New and Updated Drug Monographs — Fri, 06 Jan 2012 07:00:00 +0100

Nexterone (Amiodarone HCl Injection) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

FDA revises simvastatin dose when combined with amiodarone

Modern Medicine — Thu, 05 Jan 2012 23:35:52 +0100

FDA revised the dose limitation for simvastatin from 10 mg to 20 mg when it is co-administered with the cardiac drug amiodarone and the drug labels for Zocor and generics as well as Vytorin have been updated to reflect this correction. (Source: Modern Medicine)

amiodarone, Cordarone

MedicineNet Medications General — Wed, 04 Jan 2012 07:00:00 +0100

Title: amiodarone, CordaroneCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 1/4/2012 (Source: MedicineNet Medications General)

A Neonate with Long QT Syndrome, Refractory Ventricular Arrhythmias, and Lidocaine Toxicity.

Anesthesia and Analgesia — Wed, 04 Jan 2012 05:00:00 +0100

This report discusses the implications and challenges of management of a neonate with compound long mutations. PMID: 22218697 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)

Incidence and Prevalence of Hypothyroidism in Patients Affected by Chronic Heart Failure: Role of Amiodarone.

Endocrine, Metabolic and Immune Disorders Drug Targets — Fri, 30 Dec 2011 05:00:00 +0100

Conclusions. Hypothyroidism, especially the subclinical form, frequently occurs in patients affected by CHF receiving amiodarone therapy. Given the unfavorable impact of hypothyroidism on the progression and prognosis of CHF, and the opportunity to adequately manage thyroid failure by means of levothyroxine replacement therapy without the need to withdraw amiodarone, we recommend regular testing of thyroid function in CHF patients, in particular in those submitted to amiodarone therapy, in order to early diagnose a condition of hypothyroidism and titrate substitutive treatment. PMID: 22214334 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)

A randomized trial of budiodarone in paroxysmal atrial fibrillation

Journal of Interventional Cardiac Electrophysiology — Wed, 28 Dec 2011 16:51:20 +0100

Conclusions In this preliminary study, budiodarone at both higher doses significantly reduced AT/AFB. The study is novel because dual-chamber pacemakers, previously placed for standard clinical indications, were successfully used to monitor AT/AFB. Content Type Journal ArticlePages 1-9DOI 10.1007/s10840-011-9636-3Authors Michael D. Ezekowitz, Lankenau Medical Center, Medical Science Building, 100 Lancaster Avenue, Suite 380, Wynnewood, PA 19096, USARangadham Nagarakanti, Vanderbilt University, Nashville, TN, USAAndrzej Lubinski, Medical University Hospital, Lodz, PolandOlga Bandman, ARYx Therapeutics, Fremont, CA, USADaniel Canafax, ARYx Therapeutics, Fremont, CA, USADavid J. Ellis, ARYx Therapeutics, Fremont, CA, USAPeter G. Milner, ARYx Therapeutics, Fremont, CA, U...

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Traces of certain drug molecules can enhance heme-enzyme catalytic outcomes.

Biochemical and Biophysical Research communications — Mon, 26 Dec 2011 05:00:00 +0100

We report that trace amounts (nano- to picomolar concentrations) of dapsone and amiodarone in reaction mixtures of structurally and functionally distinct heme enzymes gave increased product formation rates from diverse substrates. These enhancements are found to be lowered by mild radical quenchers; a lowering well differentiated from heme active site inhibitions. Based on the non-specific nature of the activations in the diverse heme enzyme reactions studied, a generic mechanism is proposed to explain additive-based activity enhancements in heme enzymology. PMID: 22214932 [PubMed - as supplied by publisher] (Source: Biochemical and Biophysical Research communications)

Amiodarone Hepatotoxicity

Hepatology — Fri, 23 Dec 2011 03:05:04 +0100

(Source: Hepatology)

AMIODARONE HYDROCHLORIDEtablet [Golden State Medical Supply, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 20 Dec 2011 05:00:00 +0100

Updated Date: Dec 20, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha

Toxicological Sciences — Tue, 20 Dec 2011 05:00:00 +0100

Amiodarone [2-butyl-3-(3',5'-diiodo-4’α-diethylaminoethoxybenzoyl)-benzofuran] (AMD), a class III antiarrhythmic drug, is known to cause idiosyncratic hepatotoxic reactions in human patients. One hypothesis for the etiology of idiosyncratic adverse drug reactions is that a concurrent inflammatory stress results in decreased threshold for drug toxicity. To explore this hypothesis in an animal model, male Sprague-Dawley rats were treated with nonhepatotoxic doses of AMD or its vehicle and with saline vehicle or lipopolysaccharide (LPS) to induce low-level inflammation. Elevated alanine aminotransferase (ALT), aspartate aminotransferase, alkaline phosphatase, and gamma-glutamyltransferase activities as well as increased total bile acid concentrations in serum and midzonal hepatoce...

Did you know? Why amiodarone requires diligent monitoring?

Canadian Journal of Cardiovascular Nursing — Tue, 20 Dec 2011 00:30:04 +0100

Authors: Morris D, Cameron N Abstract Amiodarone remains one of the most commonly prescribed antiarrhythmics effectively treating atrial fibrillation and ventricular arrhythmias. Diligent monitoring for potentially serious side effects especially in the elderly is paramount. PMID: 22165500 [PubMed - in process] (Source: Canadian Journal of Cardiovascular Nursing)

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FDA Flips on Simvastatin Dose With Amiodarone

MedPage Today Public Health — Sun, 18 Dec 2011 23:13:11 +0100

WASHINGTON (MedPage Today) -- The FDA has revised the daily dosing limits on the cholesterol drug simvastatin in combination with the antiarrhythmic agent. (Source: MedPage Today Public Health)

FDA Revises Dose for Simvastatin With AmiodaroneFDA Revises Dose for Simvastatin With Amiodarone

Medscape Today Headlines — Fri, 16 Dec 2011 19:48:36 +0100

The agency is raising the allowed dose for simvastatin in combination with the cardiac drug back to 20 mg after mistakenly lowering it to 10 mg in June. News Alerts (Source: Medscape Today Headlines)

Amiodarone: Hyperpigmentation in an elderly patient: case report

Reactions — Fri, 16 Dec 2011 06:55:18 +0100

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FDA revises dose limitation for concomitant use of simvastatin with amiodarone

NeLM - News — Fri, 16 Dec 2011 05:00:00 +0100

Source: FDA Area: News In June 2011, the FDA restricted the use of the highest approved dose of simvastatin (80 mg) to 40-mg to reduce the risk of myopathy. It also proportionally lowered (? 50% reduction) all the maximum safe doses of simvastatin when it is taken with certain interacting drugs. However, the simvastatin dose limitation when taken with amiodarone (in which the dose was lowered from 20 mg to 10 mg) was made in error. Unlike other interacting drugs, there were no pharmacokinetic or clinical trial data to support this dose reduction, therefore the FDA has determined that the dose limitation, when taken with amiodarone, should be restored to 20 mg This brings dosing into line with current UK recommendation from 2004. (Source: NeLM - News)

Celivarone for Maintenance of Sinus Rhythm and Conversion of Atrial Fibrillation/Flutter

Journal of Cardiovascular Electrophysiology — Thu, 15 Dec 2011 05:00:00 +0100

Conclusions: In these studies, celivarone does not appear to be efficacious in the maintenance of sinus rhythm in AF/AFL patients or for the conversion of AF/AFL patients. (J Cardiovasc Electrophysiol, Vol. pp. 1‐11) (Source: Journal of Cardiovascular Electrophysiology)

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CORDARONE (Amiodarone Hydrochloride) Tablet [Wyeth Pharmaceuticals Company, A Subsidiary Of Pfizer Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 14 Dec 2011 05:00:00 +0100

Updated Date: Dec 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The Management of Patients with Atrial Fibrillation and Dronedarone's Place in Therapy.

Advances in Therapy — Mon, 12 Dec 2011 05:00:00 +0100

Authors: Cohen M, Boiangiu C Abstract The pharmacologic management of atrial fibrillation (AF) includes rate and rhythm control strategies. Antiarrhythmic agents (eg, amiodarone, flecainide, and propafenone) are limited by serious toxicities (including proarrhythmic effects and pulmonary toxicity), which may lead to a reduced net clinical efficacy of rhythm control strategies. Dronedarone, a new antiarrhythmic agent, is effective in the maintenance of sinus rhythm. Dronedarone has also been shown to reduce ventricular rate and the incidence of hospitalization due to cardiovascular events. Dronedarone is recommended by the 2011 American College of Cardiology Foundation/American Heart Association/Heart Rhythm Society guidelines update for the management of AF patients with no or mini...

The population pharmacokinetics of R‐ and S‐warfarin: effect of genetic and clinical factors

British Journal of Clinical Pharmacology — Sat, 10 Dec 2011 06:49:01 +0100

CONCLUSIONSOur analysis, based on exposure rather than dose, provides quantitative estimates of the clinical and genetic factors impacting on the clearance of both the S‐ and R‐enantiomers of warfarin, which can be used in developing improved dosing algorithms. (Source: British Journal of Clinical Pharmacology)

Risk factors of vitamin K antagonist overcoagulation

QJM — Sat, 10 Dec 2011 05:00:00 +0100

Conclusion: The knowledge of predictive factors of VKA-related overcoagulation seems of utmost importance to improve patients’ management. Our study underlines the fact that the potential of drug interaction should be taken into account when choosing amiodarone for patients receiving VKAs. Interestingly, long-term (>6 month) statin therapy may be a protective factor of VKA overcoagulation. Our findings, therefore, suggest that there may be no need to switch long-term users of VKA and statin to a safer alternative therapy. (Source: QJM)

AMIODARONE HYDROCHLORIDEtablet [Teva Pharmaceuticals USA Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 09 Dec 2011 05:00:00 +0100

Updated Date: Dec 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Importance of 99mTc-sestaMIBI thyroid scan in a case of amiodarone-induced thyrotoxicosis

Arquivos Brasileiros de Endocrinologia e Metabologia — Sun, 04 Dec 2011 08:16:21 +0100

Amiodarone (AM)-induced thyrotoxicosis (AIT) is a condition with uncertainties from the diagnostic and therapeutic standpoints. A 54-year old male was referred to the hospital due to thyrotoxicosis. He had history of atrial fibrillation medicated with AM. No history of pre-existing thyroid disease was present, thyroid palpation revealed no goiter, and there were no signs of Graves' ophthalmopathy. Thyroid autoantibodies and thyroid-stimulating hormone receptor antibodies (TRABs) were negative. Thyroid and Doppler ultrasounds were normal. 99mTc-sestaMIBI thyroid scan (STS) showed uptake with rapid washout. AM therapy was discontinued, and combined therapy was started. After a long course of glucocorticoid and thionamides, the patient became euthyroid. It is necessary to distinguish between ...

Atrial Selective Effect of Amiodarone to Increase Threshold of Excitation

Pacing and Clinical Electrophysiology : PACE — Fri, 02 Dec 2011 05:00:00 +0100

We report a case of a patient with dual‐chamber pacing, with stable thresholds on repeated measurements on the last year, who presented severe increase of atrial pacing threshold resulting in loss of atrial capture after a year of treatment with amiodarone. Thresholds were normalized once amiodarone was removed. Ventricular thresholds were not affected. (PACE 2011; 1–4) (Source: Pacing and Clinical Electrophysiology : PACE)

Amiodarone: Hypothyroidism with cardiac tamponade in an elderly patient: case report

Reactions — Thu, 01 Dec 2011 07:29:01 +0100

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Life-threatening Cardiac Arrhythmia after a Single Dose of Nebulized Epinephrine in Pediatric Emergency Department

Journal of Tropical Pediatrics — Wed, 30 Nov 2011 05:00:00 +0100

We present a case of critical cardiac arrhythmia developed at the Pediatric Emergency Department in an otherwise healthy infant after receiving 3 mg of l-epinephrine (1:1000) nebulization over a 90 min period for a diagnosis of bronchiolitis. Unstable ventricular tachycardia was found after the nebulization therapy that required chemical cardioversion. Frequent premature ventricular contractions (PVCs) were found initially following the cardiac insult that was controlled with oral amiodarone, and disappeared during follow-up. Although epinephrine inhalation is generally safe, adverse life-threatening events could be unpredictable and may evolve even after a single dose of nebulized epinephrine. (Source: Journal of Tropical Pediatrics)

Treatment of Amiodarone-Induced Thyrotoxicosis Type 2: A Randomized Clinical Trial.

The Journal of Clinical Endocrinology and Metabolism — Wed, 30 Nov 2011 05:00:00 +0100

Conclusion:Euthyroidism was reached despite continuation of amiodarone in all patients. Prednisone remains the preferred treatment modality of AIT type 2, because perchlorate given alone or in combination with prednisone had no better outcomes. PMID: 22130792 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

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The electro‐mechanical window in anaesthetized guinea‐pigs: a new marker for Torsade de Pointes risk screening

British Journal of Pharmacology — Tue, 29 Nov 2011 05:00:00 +0100

Conclusions and implications: A decreased E‐M window was consistently observed with drugs documented to have high TdP risk, but not with drugs with low or no TdP risk. These results suggest the E‐M window in anaesthetized guinea‐pigs is a risk marker for TdP in man. (Source: British Journal of Pharmacology)

Prophylaxis Against Atrial Fibrillation After Coronary Bypass Surgery: Beneficial Effect of Metoprolol but not of Amiodarone

Heart, Lung and Circulation — Fri, 25 Nov 2011 02:38:01 +0100

Introduction: Multiple agents to prevent atrial fibrillation (AF) after coronary artery bypass graft (CABG) surgery have been investigated. Several studies have investigated β-blockers and amiodarone separately with promising results. We aimed to investigate pharmacologic prophylaxis against AF using metoprolol and metoprolol in combination with amiodarone (Source: Heart, Lung and Circulation)

ALPHEE: No benefit of celivarone in preventing ICD shocks

theHeart.org — Wed, 23 Nov 2011 19:00:55 +0100

Although amiodarone, included as a calibrator arm, reduced the number of shocks, it also increased mortality, sending a safety signal in this population. (Source: theHeart.org)

Amiodarone: Pulmonary abnormalities in an elderly patient: case report

Reactions — Tue, 22 Nov 2011 06:51:47 +0100

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Amiodarone: Multisystem toxicity: case report

Reactions — Tue, 22 Nov 2011 06:51:47 +0100

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Dronedarone prevents microcirculatory abnormalities in the left ventricle during atrial tachypacing

British Journal of Pharmacology — Mon, 21 Nov 2011 05:00:00 +0100

Conclusions and implications: Dronedarone abolishes RAP‐induced ventricular microcirculatory abnormalities by reducing oxidative stress/ischemia related gene and protein expression in the ventricle. (Source: British Journal of Pharmacology)

Retrospective evaluation of the use of amiodarone in dogs with arrhythmias (from 2003 to 2010)

The Journal of Small Animal Practice — Sat, 19 Nov 2011 05:00:00 +0100

Objectives: To evaluate the efficacy of amiodarone in dogs with refractory supraventricular and ventricular arrhythmias and to document the side effects in treated dogs.Methods: Records of 28 dogs were retrospectively searched to document indication for amiodarone administration, heart rate, alkaline phosphatase, alanine aminotransferase, thyroxine (T4) and thyroid stimulating hormone values before and after starting treatment and during follow‐up periods.Results: Sixteen dogs with supraventricular and 12 dogs with ventricular arrhythmias were treated with amiodarone. Amiodarone treatment significantly reduced the heart rate (P<0.001) and resulted in improvement in the severity of the arrhythmia and clinical signs in 26 dogs. There were no significant differences in alkaline phosphata...

Diffuse intestinal pneumatosis and massive hepatic portal gas

Emergency Medicine Journal — Fri, 18 Nov 2011 05:00:00 +0100

A patient with a history of arterial hypertension, chronic atrial fibrillation treated with amiodarone and ticlopidin, hypercholesterolaemia and acute myocardial infarction 20 years ago presented to the emergency room after having diarrhoea and vomiting for the last 10 days, complicated with progressive abdominal pain in the last 24 h. During the initial evaluation, arterial hypotension, tachycardia and subicteric escleral dye were prominent symptoms. Physical examination showed abdominal distension and diffuse painful palpation, without peritoneal irritation signs. Lab tests showed a pH of 7, serum bicarbonate of 6 mmol/l, lactic acid of 9.2 mmol/l and serum creatinine of 3.6 mg/dl. Diffuse small and large bowel dilatations were found on a plain abdominal x-r...

AMIODARONE HYDROCHLORIDE (Amiodarone Hydrochloride) Tablet [Med Health Pharma LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 17 Nov 2011 05:00:00 +0100

Updated Date: Nov 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Amiodarone: Ventricular tachycardia and ventricular fibrillation leading to death: case report

Reactions — Wed, 16 Nov 2011 21:59:42 +0100

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Clinical and echocardiographic correlates of intra-atrial conduction delay

Europace — Wed, 16 Nov 2011 05:00:00 +0100

Conclusion This study is the largest to investigate the relation between the atrial conduction time, underlying heart diseases, and echocardiographic parameters. We found that the PA-TDI was independently prolonged in patients with a history of AF, hypertension, valve disease, higher age, and a higher BMI. Signs of diastolic dysfunction, valve incompetence, and enlarged atrium or aortic root on the echocardiogram were associated with a prolonged PA-TDI. This suggests that early and aggressive treatment of hypertension, diastolic dysfunction, and obesity could prevent intra-atrial conduction delay. (Source: Europace)

Amiodarone-Induced Thyrotoxicosis with Thyroid Papillary Cancer in Multinodular Goiter: Case Report

Medical Principles and Practice : Last 20 articles — Tue, 15 Nov 2011 23:00:00 +0100

Med Princ Pract (DOI:10.1159/000333697) (Source: Medical Principles and Practice : Last 20 articles)

Temporary ventricular overdrive pacing for electrical storm after coronary artery bypass grafting

General Thoracic and Cardiovascular Surgery — Mon, 14 Nov 2011 17:03:44 +0100

Abstract A 57-year-old man who had been receiving chemotherapy for multiple myeloma complained of chest pain and was diagnosed with coronary artery disease. Coronary artery bypass grafting without cardiopulmonary bypass was performed smoothly, and extubation was done in the operating room. The next evening, cluster of ventricular tachycardia and fibrillation triggered by ventricular premature contractions occurred and required multiple electrical defibrillations. Despite intravenous administration of lidocaine, amiodarone, magnesium, and β-blocker, the storm sustained and was suppressed only by temporary ventricular overdrive pacing. He was discharged on foot. Content Type Journal ArticleCategory Case ReportPages 756-759DOI 10.1007/s11748-010-0771-zAuthors Toshihito...

Efficacy and Safety of Celivarone, With Amiodarone as Calibrator, in Patients With an Implantable Cardioverter-Defibrillator for Prevention of Implantable Cardioverter-Defibrillator Interventions or Death: The ALPHEE Study.

Circulation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: Kowey PR, Crijns HJ, Aliot EM, Capucci A, Kulakowski P, Radzik D, Roy D, Connolly SJ, Hohnloser SH, Abstract BACKGROUND: . Unique identifier: NCT00993382. PMID: 22082672 [PubMed - as supplied by publisher] (Source: Circulation)

Is the determination of the defibrillation threshold in patients with an implantable cardioverter–defibrillator still required?

Herzschrittmachertherapie und Elektrophysiologie — Fri, 11 Nov 2011 12:49:55 +0100

Conclusion Our results demonstrate that the 10 J SM would have been achieved intraoperatively in all patients with virtual HOD ICDs. Thus, determination of the DFT during implantation does not seem to be obligatory. However, in patients receiving AA agents, DFT testing is still required. Content Type Journal ArticleCategory Original ContributionPages 1-5DOI 10.1007/s00399-011-0150-1Authors M. Licka, Abteilung für Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Heidelberg, Heidelberg, GermanyL. Jahn, Innere Medizin 1, Diakonieklinikum Schwäbisch Hall, Diakoniestr. 10, 74523 Schwäbisch Hall, GermanyK. Kelemen, Abteilung für Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Heidelberg, Heidelberg, GermanyF. Voss, Abteilung für Ka...

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Amiodarone: Optic neuropathy: case report

Reactions — Thu, 10 Nov 2011 08:03:53 +0100

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Amiodarone/colchicine/diltiazem/tacrolimus: Various toxicities: 16 case reports

Reactions — Thu, 10 Nov 2011 08:03:53 +0100

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Evaluation of defibrillation safety margin in modern implantable cardioverter defibrillators after administration of amiodarone

Clinical Research in Cardiology — Fri, 04 Nov 2011 16:50:36 +0100

Conclusion Repeat defibrillation testing after administration of amiodarone therapy rarely fails in patients with left-sided devices. We observed a higher test failure in patients with a device in the right-subpectoral position although this subgroup was small. Repeat defibrillator testing is safe as no relevant complications were observed. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00392-011-0379-zAuthors Julia Köbe, Division of Clinical and Experimental Electrophysiology, Department of Cardiology and Angiology, University Hospital of Münster, Münster, GermanyFlorian Reinke, Division of Clinical and Experimental Electrophysiology, Department of Cardiology and Angiology, University Hospital of Münster, Münster, GermanyDirk G. Deche...

Early Life-Stage Toxicity of Eight Pharmaceuticals to the Fathead Minnow, Pimephales promelas.

Archives of Environmental Contamination and Toxicology — Fri, 04 Nov 2011 04:00:00 +0100

Authors: Overturf MD, Overturf CL, Baxter D, Hala DN, Constantine L, Venables B, Huggett DB Abstract Human pharmaceuticals are routinely being detected in the environment, and there is growing concern about whether these drugs could elicit effects on aquatic organisms. Regulatory paradigms have shifted accordingly, with a greater emphasis on chronic toxicity data compared with acute data. The Organisation for Economic Co-operation and Development 210 Early Life Stage Test has been proposed as a good measure of the potential for pharmaceuticals to elicit chronic toxicity. To begin building a data set regarding the early life-stage toxicity of pharmaceuticals to fish, fathead minnows (FHM) were exposed to amiodarone, carbamazepine, clozapine, dexamethasone, fenofibrate, ibuprofen, no...

Ranolazine versus amiodarone for prevention of postoperative atrial fibrillation

Future Cardiology — Thu, 03 Nov 2011 13:51:34 +0100

Future Cardiology , November 2011, Vol. 7, No. 6, Pages 733-737. (Source: Future Cardiology)

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Poster presentations

Pacing and Clinical Electrophysiology : PACE — Tue, 01 Nov 2011 04:00:00 +0100

Conclusions: In our study statin therapy is associated with a lower incidence of non‐sustained ventricular tachycardias in patients with coronary artery disease and ICDs but does not influence overall mortality and appropriate or inappropriate intervention of the device.P002QUINIDINE: AN “ENDANGERED SPECIES” DRUG APPROPRIATE FOR MANAGEMENT OF ELECTRICAL STORM IN BRUGADA SYNDROMETheofilogiannakos EK; Paraskevaidis S; Kamperidis V; Chatzizisis Y; Tsilonis K; Dakos G; Vassilikos V; Styliadis IH 1st Cardiology Department, AHEPA Hospital, Aristotle University Medical School, ThessalonThe clinical manifestation of Brugada Syndrome (BS) varies from asymptomatic form to electrical storm and sudden cardiac death. We report two cases of BS that were presented with electrical storm. A 38‐year...

Prophylactic amiodarone reduces junctional ectopic tachycardia after tetralogy of Fallot repair

The Journal of Thoracic and Cardiovascular Surgery — Mon, 31 Oct 2011 04:00:00 +0100

Conclusions: Prophylactic amiodarone is well tolerated and significantly associated with a decreased incidence of junctional ectopic tachycardia after tetralogy repair. (Source: The Journal of Thoracic and Cardiovascular Surgery)

Cardiovascular Outcomes in the AFFIRM Trial (Atrial Fibrillation Follow-Up Investigation of Rhythm Management) An Assessment of Individual Antiarrhythmic Drug Therapies Compared With Rate Control With Propensity Score-Matched Analyses

Journal of the American College of Cardiology — Mon, 31 Oct 2011 00:58:28 +0100

Conclusions: In AFFIRM, composite mortality and CVH outcomes differed for Rate and AADs due to differences in CVH; CVH event rates during follow-up were high for all cohorts, but they were higher for all groups on AADs. Death, intensive care unit hospital stay, and non-CV death were more frequent with amiodarone. (Atrial Fibrillation Follow-Up Investigation of Rhythm Management; NCT00000556) (Source: Journal of the American College of Cardiology)

Provider and pharmacist responses to warfarin drug-drug interaction alerts: a study of healthcare downstream of CPOE alerts.

Journal of the American Medical Informatics Association — Fri, 28 Oct 2011 04:00:00 +0100

ConclusionThe large number of CPOE alerts may lead to inappropriate responses by providers and pharmacists. The high rate of ADE suggests a need for improved medication management systems for patients on warfarin. This study highlights the possibility of alert fatigue contributing to the high prevalence of inappropriate alert over-ride text responses. PMID: 22037888 [PubMed - as supplied by publisher] (Source: Journal of the American Medical Informatics Association)

Amiodarone/itraconazole interaction: Cardiac arrest in an elderly patient: case report

Reactions — Wed, 26 Oct 2011 13:05:17 +0100

(Source: Reactions)

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Basic and advanced paediatric cardiopulmonary resuscitation – Guidelines of the Australian and New Zealand Resuscitation Councils 2010

Journal of Paediatrics and Child Health — Fri, 21 Oct 2011 04:00:00 +0100

AbstractGuidelines for basic and advanced paediatric cardiopulmonary resuscitation (CPR) have been revised by Australian and New Zealand Resuscitation Councils. Changes encourage CPR out‐of‐hospital and aim to improve the quality of CPR in‐hospital. Features of basic CPR include: omission of abdominal thrusts for foreign body airway obstruction; commencement with chest compression followed by ventilation in a ratio of 30:2 or compression‐only CPR if the rescuer is unwilling/unable to give expired‐air breathing when the victim is ‘unresponsive and not breathing normally’. Use of automated external defibrillators is encouraged. Features of advanced CPR include: prevention of cardiac arrest by rapid response systems; restriction of pulse palpation to 10 s to diagnosis cardiac ...

[Amiodarone and thyroid function].

Kardiologia Polska — Thu, 20 Oct 2011 12:35:03 +0100

Authors: Siuda K, Kolesińska Z, Niedziela M PMID: 21594842 [PubMed - indexed for MEDLINE] (Source: Kardiologia Polska)

Coronary Artery Disease Potentiates Response to Dofetilide for Rhythm Control of Atrial Fibrillation

Pacing and Clinical Electrophysiology : PACE — Thu, 20 Oct 2011 04:00:00 +0100

Conclusions:In this large cohort of patients with AF, underlying coronary disease was significantly associated with dofetilide success. This finding may have utility for clinical decisions regarding initiation of dofetilide. (PACE 2011; 1–4) (Source: Pacing and Clinical Electrophysiology : PACE)

Multaq 400mg tablets (Dronedarone)- Revised SPC

NeLM - SPC Changes — Thu, 20 Oct 2011 04:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes There have been significant updates to several sections of the SPC, the following sections have all been updated: ? Section 4.1 - Therapeutic Indication Restriction of indication to patients with sinus rhythm when other options have been considered following emea recommendations Section 4.2 - Posology and method of administration Initiation and monitoring to be conducted by a specialist, info for switching from amiodarone to dronedarone added. Section 4.3 - Contraindications Contraindications for permanent AF, left ventricular systolic dysfunction, heart failure and patients with liver or lung toxicity related to previous use of amiodarone use. Section 4....

Guidelines for the Diagnosis and Management of Arrhythmogenic Right Ventricular Cardiomyopathy

Heart, Lung and Circulation — Mon, 17 Oct 2011 04:00:00 +0100

Conclusions: Arrhythmogenic right ventricular cardiomyopathy is more common than previously believed. Preliminary evidence supports improved sensitivity without loss of specificity using the revised Task Force criteria. The genetics of the disease are complex but should ultimately advance diagnosis and management. (Source: Heart, Lung and Circulation)

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Multiple pulmonary nodules: and if it was not a cancer

Thorax — Fri, 14 Oct 2011 04:00:00 +0100

A 72-year-old woman was admitted in the Cardiology Department for respiratory insufficiency. ECG revealed atrial fibrillation, and echocardiography revealed heart failure with an estimated left ventricular ejection fraction of 25%. Chest roentgenogram revealed multiple nodules, and chest CT scan revealed multiple dense nodules surrounded by ground-glass attenuation (halo sign) with unilateral pleural effusion (figure 1). A bronchoalveolar lavage was performed to rule out any infection. Anticoagulation was begun before a successful external cardioversion, followed by oral amiodarone treatment. Diuretics were increased without any other medication. One week later, a control chest CT scan revealed the disappearance of all nodules, as well as of the pleural effusion (figure 2). Learning points...

Prophylaxis and Management of Atrial Fibrillation After General Thoracic Surgery

Thoracic Surgery Clinics — Fri, 14 Oct 2011 04:00:00 +0100

Atrial fibrillation (AF) commonly affects patients after general thoracic surgery. Postoperative AF increases hospital stay and charges. Effective prophylaxis and treatment is the goal. Calcium channel blockers prevent postoperative AF. Beta blockers are a less viable choice. Amiodarone prophylaxis should be avoided in patients with pulmonary dysfunction or who require pneumonectomy. In management of AF, a brief trial of rate-control agents is appropriate; however, chemical cardioversion with rhythm-control agents should be instituted after 24 hours. High-risk patients with history of stroke or transient ischemic attack, or with two or more risk factors for thromboembolism should receive anticoagulation therapy. (Source: Thoracic Surgery Clinics)

Amiodarone-induced acute hepatotoxicity

European Journal of Clinical Pharmacology — Tue, 11 Oct 2011 15:54:15 +0100

Content Type Journal ArticleCategory Letter to the EditorsPages 1-2DOI 10.1007/s00228-011-1126-0Authors Usha Rao, West Suffolk Hospital, Bury St Edmunds, UKAjit Agarwal, West Suffolk Hospital, Bury St Edmunds, UK Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology)

Cardiac Amyloidosis: Evolving Approach to Diagnosis and Management

Current Treatment Options in Cardiovascular Medicine — Tue, 11 Oct 2011 15:53:02 +0100

Opinion statement The systemic amyloidoses are a group of heterogeneous disorders characterized by extracellular deposition of misfolded fibrillar protein that results in organ dysfunction. Involvement of the heart (cardiac amyloidosis) is manifest by increased cardiac wall thickness and impairment of myocardial diastolic and systolic properties, changes that result in heart failure, dysrhythmia, and death. Amyloidosis is classified by precursor protein, with light-chain (AL) and transthyretin (TTR) disease being most common in the United States. TTR amyloid can result from misfolding of variant TTR, a genetically inherited disease, or wild-type TTR, an acquired form of disease (termed senile systemic amyloidosis). In recent years, advances in the diagnosis and treatment o...

Population Pharmacokinetic Analysis of the Oral Thrombin Inhibitor Dabigatran Etexilate in Patients With Non‐Valvular Atrial Fibrillation from the RE‐LY Trial

Journal of Thrombosis and Haemostasis — Wed, 05 Oct 2011 04:00:00 +0100

Conclusions: The analysis provides a thorough PK characterization of dabigatran in the AF patient population from RE‐LY. None of the covariates investigated with the exception of renal function warrant dose adjustment. (Source: Journal of Thrombosis and Haemostasis)

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[Intermittent short QT interval in a patient with sudden cardiac death].

Archivos de Cardiologia de Mexico — Sat, 01 Oct 2011 04:00:00 +0100

Authors: Dorantes-Sánchez M, López-Delgado A, Castro-Hevia J, Méndez-Rosabal A Abstract This paper presents a 21 years-old-male without structural heart disease who was reanimated from a sudden cardiac death event. His familial history included two siblings suddenly dead in their first year of life. The patient had 10 episodes of ventricular tachycardia (some of them were registered). Electrocardiographically abnormalities were an intermittent short QT interval (280 ms), short QTc (320 ms) and a short ST segment. QT interval subsequently returned to a normal range (360 ms or more), while occasionally a length of 335 ms was recorded. The electrophysiological study findings (AH and HV intervals, refractory periods) were normal. The patient refused the implantable cardioverter defi...

Dofetilide Reduces the Frequency of Ventricular Arrhythmias and Implantable Cardioverter Defibrillator Therapies

Journal of Cardiovascular Electrophysiology — Wed, 28 Sep 2011 04:00:00 +0100

Conclusions: In patients with an ICD and ventricular arrhythmias, dofetilide decreases the frequency of VT/VF and ICD therapies even when other antiarrhythmic agents, including amiodarone, have previously been ineffective. Recurrences still occur in some patients requiring catheter ablation, mechanical support, or heart transplantation. (J Cardiovasc Electrophysiol, Vol. pp. 1‐6) (Source: Journal of Cardiovascular Electrophysiology)

Lexicomp Adds Advanced Life Support Calculators

What's New on JEFFLINE — Tue, 27 Sep 2011 13:54:52 +0100

Two new Advanced Life Support Calculators have been added to Lexicomp, Jefferson’s main drug database. The Advanced Life Support Neonatal Calculation provides both weight-based dosing and volumes to be administered in one easy-to-read table. Dosing is based on the Neonatal Resuscitation Program and Pediatric Advanced Life Support Guidelines. The Advanced Life Support Pediatric Calculator now estimates weight based on length and body habitus when the actual weight is unknown. This allows for more accurate dosing when the weight is not available. Both calculators are now be available for use on all handheld platforms with the Lexi-CALC module. Drugs covered include adenosine, amiodarone, atropine, calcium chloride, calcium gluconate, dextrose, epinephrine, lidocaine, magnesium sulfa...

PACERONE (Amiodarone Hydrochloride) Tablet [Upsher-Smith Laboratories, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 27 Sep 2011 05:00:00 +0100

Updated Date: Sep 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Amiodarone/simvastatin interaction: Rhabdomyolysis in an elderly patient: case report

Reactions — Thu, 22 Sep 2011 07:55:36 +0100

(Source: Reactions)

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AMIODARONE HYDROCHLORIDEtablet [Eon Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 21 Sep 2011 05:00:00 +0100

Updated Date: Sep 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A new mechanism preventing proarrhythmia in chronic heart failure: rapid phase-III repolarization explains the low proarrhythmic potential of amiodarone in contrast to sotalol in a model of pacing-induced heart failure

European Journal of Heart Failure — Wed, 21 Sep 2011 04:00:00 +0100

Conclusion Chronic amiodarone results in a rapid phase-III-repolarization and does not increase dispersion of repolarization. These electrophysiological findings are present in healthy hearts and are preserved in heart failure. This contributes to the low proarrhythmic potential of amiodarone in heart failure. (Source: European Journal of Heart Failure)

Mitochondrial oxidative stress and respiratory chain dysfunction account for liver toxicity during amiodarone but not dronedarone administration.

Free Radical Biology and Medicine — Sat, 17 Sep 2011 04:00:00 +0100

In this study, we analyzed the effects of the two drugs on liver mitochondrial function by administering an equivalent human dose to a rat model. Amiodarone increased mitochondrial H(2)O(2) synthesis, which in turn induced cardiolipin peroxidation. Moreover, amiodarone inhibited Complex I activity and uncoupled oxidative phosphorylation, leading to a reduction in the hepatic ATP content. We also observed a modification of membrane phospholipid composition after amiodarone administration. N-acetylcysteine completely prevented such effects. Although dronedarone shares with amiodarone the capacity to induce uncoupling of oxidative phosphorylation, it did not show any of the oxidative effects and did not impair mitochondrial bioenergetics. Our data provide important insights into the mechanism...

PACERONE (Amiodarone Hydrochloride) Tablet [APHENA PHARMA SOLUTIONS - TENNESSEE, INC.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 16 Sep 2011 05:00:00 +0100

Updated Date: Sep 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Influence of Long-term Statin use in Type 2 Diabetic Patients on Thyroid Nodularity in Iodine-sufficient Area

Experimental and Clinical Endocrinology and Diabetes — Tue, 13 Sep 2011 04:00:00 +0100

Exp Clin Endocrinol Diabetes 2011; 119: 497-501DOI: 10.1055/s-0031-1283123Statins have marked beneficial effects on lipid profile, but also have pleiotropic actions. A previous study in an iodine-deficient area suggested that statin use is associated with reduced thyroid volume and nodularity. We performed this study to investigate how long-term statin use in type 2 diabetic patients affects thyroid nodularity in iodine-sufficient area.We recruited euthyroid type 2 diabetic patients, receiving statin therapy continuously for at least 5 years (statin group) and, age and sex matched statin-naive type 2 diabetic patients (control group). Subjects with past history of cancer, thyroid disease or treatment with lithium or amiodarone; family history of thyroid cancer; palpable goiter or thyroid n...

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Cardiac Arrest Provoked by Itraconazole and AmiodaroneCardiac Arrest Provoked by Itraconazole and Amiodarone

Medscape Today Headlines — Mon, 12 Sep 2011 10:42:25 +0100

This case demonstrates that coadministration of itraconazole and amiodarone can lead to serious cardiovascular adverse events in patients who are critically ill. Journal of Medical Case Reports (Source: Medscape Today Headlines)

Pharmacological conversion of recent atrial fibrillation: a randomized, placebo-controlled study of three antiarrhythmic drugs.

Anadolu Kardiyol Der... — Mon, 12 Sep 2011 04:00:00 +0100

CONCLUSION: In patients with recent-onset AF, oral flecainide, amiodarone or propafenone are superior to placebo in restoring sinus rhythm within the 24-hour period following the drug intake. PMID: 21911317 [PubMed - as supplied by publisher] (Source: Anadolu Kardiyol Der...)

Thyroxine monotherapy without amiodarone enhances atrial fibrillation recurrences in amiodarone-induced hypothyroidism

International Journal of Cardiology — Mon, 12 Sep 2011 04:00:00 +0100

Atrial fibrillation (AF) is the most sustained cardiac arrhythmia requiring medical care. Amiodarone is a di-iodinated benzofuran derivative widely used for preventing the recurrences of AF . Although amiodarone is the most effective agent in rhythm control of AF , the adverse effects of amiodarone frequently result in treatment discontinuations. Hypothyroidism caused by the iodine in amiodarone is one of the most frequent and important adverse effects. The incidence of amiodarone-induced hypothyroidism varies from 1 to 32% . The report of amiodarone-induced hypothyroidism in Asia is about 10 to 20% . However, the optimal treatment for amiodarone-induced hypothyroidism remains unclear. (Source: International Journal of Cardiology)

Syncope following 'pill-in-the-pocket' treatment of atrial fibrillation with propafenone plus quinidine

Heart — Wed, 07 Sep 2011 04:00:00 +0100

To the Editor The important report by Alboni et al1 not only documents risks associated with the use of propafenone during ‘pill-in-the-pocket’ (PIP) therapy for paroxysmal atrial fibrillation (PAF) but also hints at techniques by which its use may be made safer. The primary metabolism of propafenone occurs through hepatic CYP4502D6 isoenzyme activity, resulting in differences between the safety of propafenone administered intravenously and orally. CYP2D6 activity may also be strongly inhibited by other commonly prescribed medications, including quinidine, amiodarone, cimetidine, erythromycin and most selective serotonin re-uptake inhibitor antidepressants, whose concurrent use can be expected to increase both their own concentrations and that of propafenone. One hundred millig...

Ranolazine Reduces Ventricular Tachycardia Burden and ICD Shocks in Patients with Drug‐Refractory ICD Shocks

Pacing and Clinical Electrophysiology : PACE — Fri, 02 Sep 2011 23:00:00 +0100

Conclusion: Ranolazine proved effective in reducing VT burden and ICD shocks in patients with AAD‐refractory VT. Ranolazine should be further tested for this indication and considered for clinical application when other options have proven ineffective. (PACE 2011;1–7) (Source: Pacing and Clinical Electrophysiology : PACE)

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Sirolimus-induced Pneumonitis Complicated by Pentamidine-induced Phospholipidosis in a Renal Transplant Recipient: A Case Report

Transplantation Proceedings — Thu, 01 Sep 2011 04:00:00 +0100

Abstract: The proliferation signal inhibitors (PSIs)—sirolimus, everolimus, and temsirolimus—have been associated with a noninfectious pneumonitis characterized by lymphocytic alveolitis and bronciolitis obliterans with organizing pneumonia (BOOP). This condition usually occurs within the first year. Herein we presented a case of a deceased donor renal transplant with interstitial pneumonitis developing 6 years after a switch from tacrolimus to sirolimus due to chronic graft dysfunction. After the addition of intravenous pentamidine due to the suspicion of Pneumocystis pneumonia, there was marked clinical deterioration requiring intubation. Open lung biopsy revealed sirolimus-induced pulmonary toxicity (BOOP) with the additional finding of a drug-induced phospholipidosis (DIPL) that we...

Acquired Long QT Interval: A Case Series of Multifactorial QT Prolongation

Clinical Cardiology — Wed, 31 Aug 2011 23:00:00 +0100

Conclusions:This case series highlights the risks of polypharmacy in the development of LQT and TdP. It illustrates the importance of early detection of LQT in patients with multiple risk factors in ensuring appropriate treatment. © 2011 Wiley Periodicals, Inc.The authors have no funding, financial relationships, or conflicts of interest to disclose. (Source: Clinical Cardiology)

Thyrotoxicosis and thyroiditis

Surgery (Medicine Publishing) — Wed, 31 Aug 2011 23:00:00 +0100

Abstract: Thyrotoxicosis is a common presentation of thyroid disease. The commonest cause is Graves’ disease. The clinical features including goitre, eye disease, causes and diagnosis of thyrotoxicosis are discussed. Treatment strategies of Graves’ disease include anti-thyroid drugs, radioiodine and thyroidectomy. It is important to adequately prepare patients prior to surgery to reduce the possibility of thyroid storm. The preferred surgical procedure today is a total thyroidectomy, although historically subtotal thyroidectomy was performed. Less common but relevant surgical causes of thyrotoxicosis are also discussed.Thyroiditis (thyroid inflammation) has a variety of causes. Hashimoto's thyroiditis may present with a transient thyrotoxicosis or long term hypothyroidism. Surgery is r...

Mid-term results of endoscopic mitral valve repair in combination with endocardial or epicardial ablation [Original articles]

European Journal of Cardio-Thoracic Surgery — Sun, 28 Aug 2011 23:00:00 +0100

Conclusions: It was shown with our results that one succeeds with the en bloc-ablation in treating patients with different kinds of atrial fibrillation with concurrent intervention in the mitral valve reliably and with a high rate. The combination of this procedure with endocardial interventional ablation technologies can possibly develop to a promising strategy in the hybrid therapy of the isolated chronic atrial fibrillation as a standalone procedure. (Source: European Journal of Cardio-Thoracic Surgery)

Amiodarone Supplants Lidocaine in ACLS and CPR Protocols

Anesthesiology Clinics — Sat, 27 Aug 2011 12:43:21 +0100

This article summarizes the use of Amiodarone by anesthesiologists in the operating room and during cardiopulmonary resuscitation. (Source: Anesthesiology Clinics)

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Effect of prophylactic amiodarone in patients with rheumatic valve disease undergoing valve replacement surgery.

Annals of Cardiac Anaesthesia — Fri, 26 Aug 2011 06:21:47 +0100

Authors: Kar SK, Dasgupta CS, Goswami A Abstract The study was carried out to evaluate the effect of prophylactic single-dose intravenous amiodarone in patients undergoing valve replacement surgery. Maintenance of sinus rhythm is better than maintenance of fixed ventricular rate in atrial fibrillation (AF) especially in the presence of irritable left or right atrium because of enlargement. Fifty-six patients with valvular heart disease with or without AF were randomly divided into two groups. Group I or the amiodarone group (n=28) received amiodarone (3 mg/kg in 100 ml normal saline) and group II or the control group received same volume of normal saline. The standardized protocol for cardiopulmonary bypass was maintained for all the patients. AF occurred in 7.14% patients in group...

AMIODARONE HYDROCHLORIDEinjection, Solution [Hospira, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 24 Aug 2011 05:00:00 +0100

Updated Date: Aug 24, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Continuation of Amiodarone Delays Restoration of Euthyroidism in Patients with Type 2 Amiodarone-Induced Thyrotoxicosis Treated with Prednisone: A Pilot Study.

The Journal of Clinical Endocrinology and Metabolism — Tue, 23 Aug 2011 23:00:00 +0100

Conclusions: Prednisone restores euthyroidism in most type 2 AIT patients, irrespective of amiodarone continuation or withdrawal. However, continuing amiodarone increases the recurrence rate of thyrotoxicosis, causing a delay in the stable restoration of euthyroidism and a longer exposure of the heart to thyroid hormone excess. PMID: 21865355 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

Local activation times at the high posterior wall of the left atrium during left atrial appendage pacing predict roof line block with high specificity and sensitivity

Europace — Mon, 22 Aug 2011 23:00:00 +0100

Conclusion Parameters derived from the measurement of LAT of the high posterior and anterior LA wall help guide the assessment of roof line block. (Source: Europace)

Left Stellate Ganglion Block for Continuous Ventricular Arrhythmias during Percutaneous Left Ventricular Assist Device Support.

Texas Heart Institute Journal — Sat, 20 Aug 2011 10:44:06 +0100

Authors: Loyalka P, Hariharan R, Gholkar G, Gregoric ID, Tamerisa R, Nathan S, Kar B Abstract A 58-year-old man presented with chest pain and tightness and was diagnosed with a Q-wave anterior myocardial infarction. He then developed pulseless ventricular arrhythmias, which were treated with repeated direct-current shocks and intravenous amiodarone. He underwent emergency cardiac catheterization: stents were deployed in the left anterior descending coronary artery and right coronary artery, and an intra-aortic balloon pump was inserted. Severe refractory cardiogenic shock and incessant ventricular arrhythmias compelled us to place a TandemHeart percutaneous left ventricular assist device 4 hours later. The patient's hemodynamic status stabilized, but the arrhythmias persisted for 3...

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NEXTERONE Allows For Immediate Use of Critical Antiarrhythmic Drug in Urgent Care Settings

Pharmaceutical Online News — Fri, 19 Aug 2011 19:41:00 +0100

Baxter International Inc. announced that it has launched NEXTERONE® (amiodarone HCl) Premixed Injection, the first and only ready-to-use premixed intravenous (IV) bag version of the antiarrhythmic agent amiodarone in the United States. (Source: Pharmaceutical Online News)

Baseline and Follow-up Laboratory Monitoring of Cardiovascular Medications (September).

The Annals of Pharmacotherapy — Wed, 17 Aug 2011 23:00:00 +0100

CONCLUSIONS Baseline assessment of cardiovascular medication monitoring is variable. Quality measurement of adherence to BBW recommendations may improve monitoring. PMID: 21852593 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Major bleeding risk associated with warfarin and co‐medications in the elderly population

Pharmacoepidemiology and Drug Safety — Tue, 16 Aug 2011 23:00:00 +0100

ConclusionsModels assessing bleeding risk with warfarin should take account of the range of potentially harmful medicine combinations used in elderly people with comorbid conditions. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

n-3 polyunsaturated fatty acids in the prevention of AF recurrence after cardioversion

NeLM - News — Mon, 15 Aug 2011 23:00:00 +0100

Source: Circulation Area: News According to research published early online in Circulation, the addition of n-3 polyunsaturated fatty acids (n-3 PUFAs) to the therapy of patients with persistent atrial fibrillation (AF) who are already being treated with amiodarone and an ACE inhibitor (ACEI) or angiotensin receptor blocker (ARB) may reduce the probability of AF recurrence following cardioversion. The authors note that a role of n-3 PUFAs in the prevention of AF has been suggested based on their potential antiarrhythmics effects. Studies in this area so far have been conflicting, and a definite role for them in this setting has not been demonstrated. The purpose of the current study was to determine whether adding n-3 PUFAs to amiodarone and an ACE inhibitor (ACEI) ...

n-3 Polyunsaturated Fatty Acids in the Prevention of Atrial Fibrillation Recurrences After Electrical Cardioversion: A Prospective, Randomized Study.

Circulation — Sun, 14 Aug 2011 23:00:00 +0100

Conclusions- In patients with persistent atrial fibrillation on amiodarone and a renin-angiotensin-aldosterone system inhibitor, the addition of n-3 PUFAs 2 g/d improves the probability of the maintenance of sinus rhythm after direct current cardioversion. Our data suggest that n-3 PUFAs may exert beneficial effects in the prevention of atrial fibrillation recurrence. Further studies are needed to confirm and expand our findings. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT01198275. PMID: 21844082 [PubMed - as supplied by publisher] (Source: Circulation)

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Colchicine: tips for avoiding fatal in-hospital toxicity

The Poison Review — Sun, 14 Aug 2011 09:13:00 +0100

This article emphasizes that point, and should be read. Related post: Colchicine: be afraid, be very afraid (Source: The Poison Review)

Determinants and outcome of amiodarone‐associated thyroid dysfunction

Clinical Endocrinology — Thu, 11 Aug 2011 07:15:50 +0100

Conclusions During median follow‐up of 3·3 years, the incidence of amiodarone‐associated thyrotoxicosis was higher compared to hypothyroidism. Only general predictors for amiodarone‐associated thyroid dysfunction were observed. Discontinuation of amiodarone did not influence treatment outcome. (Source: Clinical Endocrinology)

Amiodarone: Hypothyroidism in an elderly patient: case report

Reactions — Wed, 10 Aug 2011 17:36:32 +0100

(Source: Reactions)

Amiodarone/citalopram interaction: Torsade de pointes in an elderly patient: case report

Reactions — Wed, 10 Aug 2011 17:36:32 +0100

(Source: Reactions)

Role of oral amiodarone in patients with atrial fibrillation and congestive heart failure.

Journal of Cardiology — Sun, 07 Aug 2011 23:00:00 +0100

CONCLUSIONS: Oral amiodarone helped restore SR in paroxysmal and persistent AF patients with CHF. The successful rhythm control by amiodarone resulted in the improvement of LV function and the decrease of BNP levels. PMID: 21831597 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)

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Novel electropharmacological activity of amiodarone on human HCN channels heterologously expressed in the Xenopus oocytes.

European Journal of Pharmacology — Thu, 04 Aug 2011 23:00:00 +0100

The objectives of this study were to investigate the electropharmacological activity of amiodarone on human HCN channels heterologously expressed in Xenopus laevis oocytes. hHCN channels were expressed in oocytes and studied using the standard two-electrode voltage-clamp techniques. The results show that amiodarone blocks hHCN channels heterologously expressed in the Xenopus oocytes in a concentration- and use-dependent manner, but doesn't modify the voltage dependence of activation and reversal potentials. And the removal of blockage of HCN channels by amiodarone was favored by inward current flow, not by hyperpolarizing potential. Characteristics of blockage on hHCN channels were consistent with those of amiodarone as "trapped" drugs on human ether-a-go-go-related gene (HERG) channels. T...

Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic data

European Heart Journal — Sun, 31 Jul 2011 23:00:00 +0100

Conclusion To our knowledge, these are the first genotype-guided loading and maintenance dose algorithms for PHE and ACE using large cohorts. The utility of these algorithms will be tested in randomized controlled trials. (Source: European Heart Journal)

Ranolazine may curb AF post-CABG

theHeart.org — Sat, 30 Jul 2011 19:00:20 +0100

The antianginal agent, known to have antiarrhythmic properties, could potentially be a safer, shorter-acting alternative to amiodarone in this setting. (Source: theHeart.org)

Randomised controlled trial of lipiodol transarterial chemoembolisation with or without amiodarone for unresectable hepatocellular carcinoma

Digestive and Liver Disease — Fri, 29 Jul 2011 04:00:00 +0100

Conclusions: The results of this study suggest that lipiodol transarterial chemoembolisation with anthracycline and amiodarone was safe but did not increase survival compared with lipiodol transarterial chemoembolisation with anthracycline alone in patients with hepatocellular carcinoma. (Source: Digestive and Liver Disease)

Ranolazine better than amiodarone for preventing post-CABG AF?

NeLM - News — Wed, 27 Jul 2011 23:00:00 +0100

Source: Am J Cardiology Area: News A retrospective observational study suggests that ranolazine may be more effective than amiodarone in prevention of atrial fibrillation (AF) after coronary artery bypass grafting (CABG). AF is a frequent complication of CABG, and may be treated using amiodarone, however this is a difficult drug to use and alternatives would be useful. Ranolazine is marketed as an anti-anginal agent, but it also has potentially useful anti-dysrhythmic activity. The authors of this report used data from medical records of one US hospital to carry out a retrospective cohort study comparing outcomes after CABG with the two drugs. The cohort included all patients without a history of permanent AF who had CABG without valve surgery at the hospital between June 2008 ...

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Use of the impedance threshold device: Is it underestimated in the 2010 resuscitation guidelines?

Resuscitation — Wed, 27 Jul 2011 04:00:00 +0100

We have read with the greatest interest the 2010 European Resuscitation Council (ERC) Guidelines for cardiopulmonary resuscitation (CPR) which incorporate the results of systematic reviews of a wide range of topics relating to CPR. In the CPR techniques and devices section, it is stated that routine use of the impedance threshold device (ITD) in cardiac arrest is not recommended. We were quite surprised by this recommendation, as ITD had been assigned a class IIa recommendation in the 2005 ILCOR resuscitation guidelines, when traditionally used CPR drugs such as adrenaline and amiodarone were assigned a class IIb recommendation. (Source: Resuscitation)

Ranolazine beats amiodarone for preventing post-CABG atrial fibrillation

Modern Medicine — Mon, 25 Jul 2011 23:00:00 +0100

NEW YORK (Reuters Health) - Ranolazine may be a better choice than amiodarone for minimizing atrial fibrillation (AF) after coronary artery bypass grafting (CABG), researchers suggest. (Source: Modern Medicine)

Amiodarone: Thyrotoxicosis in an elderly patient: case report

Reactions — Wed, 20 Jul 2011 16:58:58 +0100

(Source: Reactions)

AMIODARONE HYDROCHLORIDEtablet [American Health Packaging]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 20 Jul 2011 05:00:00 +0100

Updated Date: Jul 20, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effects of neferine on the pharmacokinetics of amiodarone in rats.

Biomedical Chromatography : BMC — Wed, 20 Jul 2011 03:00:25 +0100

Authors: Wan J, Zhao L, Xu C, Zhang S, Zhang Z, Zeng C, Chang M, Xiao J, Wang J Amiodarone, an iodinated benzofuran derivative with predominantly class III anti-arrhythmic effects, is used to treat supraventricular and ventricular arrhythmias. The purpose of this study was to assess the potential of neferine, an effective anti-pulmonary fibrosis drug isolated from the embryo of Nelumbo nucifera Gaertner's seeds, to alter the pharmacokinetic profile of amiodarone. Experimental Sprague-Dawley rats were randomly divided into two groups. In groups 1 and 2, amiodarone was given to rats by intragastric and intravenous administration, respectively, while neferine was co-administratered by intragastric administration. Blood samples were collected from the orbital venous plexus at indicated tim...

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Combined blockade of early and late activated atrial potassium currents suppresses atrial fibrillation in a pig model of obstructive apnea

Heart Rhythm — Mon, 18 Jul 2011 04:00:00 +0100

Conclusion: The atrial proarrhythmic effect of NTP simulating obstructive apneas is difficult to inhibit by class III antiarrhythmic drugs. Neither amiodarone nor blockade of IKr or IKur/Ito attenuated NTP-induced AERP shortening. However, the combined blockade of IKur/Ito and IKr suppressed NTP-induced AERP shortening. (Source: Heart Rhythm)

Amiodarone-induced skin hyperpigmentation

QJM — Sun, 17 Jul 2011 23:00:00 +0100

(Source: QJM)

Effects of the novel amiodarone-like compound SAR114646A on cardiac ion channels and ventricular arrhythmias in rats

Naunyn-Schmiedeberg's Archives of Pharmacology — Fri, 15 Jul 2011 15:56:21 +0100

In conclusion, SAR114646A is a multichannel blocker with improved water solubility, compared to amiodarone. In contrast to amiodarone, SAR114646A also blocks the K+ channels Ito and Isus. A potent antiarrhythmic effect as observed in rats can also be expected in other animal models. Content Type Journal ArticlePages 1-14DOI 10.1007/s00210-011-0664-4Authors Heinz Goegelein, Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, H 821, 65926 Frankfurt am Main, GermanyPatrick Gautier, Sanofi-Aventis R&D, 371, Rue du Pr Blayac, 34184 Montpellier cedex 4, FranceAlain Roccon, Sanofi-Aventis R&D, 371, Rue du Pr Blayac, 34184 Montpellier cedex 4, FranceStephen O’Connor, Sanofi-Aventis R&D, 1, Avenue Pierre Brossolette, 93185 Chilly-Mazarin cedex, FranceHartmut Ruetten, Sanofi-Aventis De...

Thyroid Effects of Generic, Brand-Name Amiodarone SimilarThyroid Effects of Generic, Brand-Name Amiodarone Similar

Medscape Pharmacist Headlines — Thu, 14 Jul 2011 14:16:57 +0100

The anti-arrhythmic drug amiodarone is linked with similar rates of thyroid effects whether patients take the brand-name drug or a generic, Canadian research shows. Reuters Health Information (Source: Medscape Pharmacist Headlines)

Amiodarone: Hypothyroidism in an infant: case report

Reactions — Wed, 13 Jul 2011 16:51:36 +0100

(Source: Reactions)

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Evaluation and validation of multiple cell lines and primary mouse macrophages to predict phospholipidosis potential.

Toxicology in Vitro — Tue, 12 Jul 2011 23:00:00 +0100

The objective of this work was to compare, optimize, and validate in vitro PLD assays in primary mouse macrophages and hepatocyte- (HepG2, HuH7) or macrophage-derived cells lines (I.13.35, RAW264.7) and to evaluate whether primary cells were better at predicting PLD. Assay precision, determined by a measure of signal to noise window (Z'), within assay variability, and day-to-day variability, using amiodarone, was generally acceptable for all cell types; however, precision limits for HepG2 and HuH7 were slightly below assay acceptance criteria. Up to 66 known PLD inducers and non-inducers were subsequently tested to validate the assays. The concordance for predicting PLD in primary macrophages, I-13.35, RAW264.7, HuH7, and HepG2 cells was 91%, 74%, 73%, 62%, and 62% respectively using a dec...

Recurrent Polymorphic Ventricular Tachycardia Treated by Ablation of Purkinje Arborization within an Infarct Border-Zone.

Texas Heart Institute Journal — Tue, 12 Jul 2011 21:00:03 +0100

Authors: Park KM, Nam GB, Choi KJ, Kim YH A 70-year-old patient with 3-vessel coronary artery disease and a left ventricular aneurysm underwent coronary artery bypass grafting, together with a surgical anterior ventricular endocardial restoration (SAVER) procedure. Four days later, he suddenly developed recurrent sustained and nonsustained polymorphic ventricular tachycardia, preceded by monomorphic ventricular premature contractions, and did not respond to any antiarrhythmic drug, including lidocaine, esmolol, or amiodarone. Repeated electrical cardioversion procedures were performed (28 in total). Mapping was performed to target the earliest site of activation in the left ventricle during the ventricular premature contractions, a site where the premature beats were preceded by Purkin...

Pulmonary Disorders Increased in AF Patients on AmiodaronePulmonary Disorders Increased in AF Patients on Amiodarone

Medscape Medical News Headlines — Tue, 12 Jul 2011 18:20:36 +0100

A new population-based study finds the incidence of pulmonary complications associated with amiodarone to be relatively low, but still 50% higher among patients with atrial fibrillation who take the antiarrhythmic drug than in those who do not. Reuters Health Information (Source: Medscape Medical News Headlines)

Safety assessment of potentially inappropriate medications use in older people and the factors associated with hospital admission.

J Pharm Pharm Sci — Tue, 12 Jul 2011 15:30:03 +0100

Conclusion: PIM use in elderly people is not a risk factor for ADR-related hospital admission. Probably, severe ADR, which lead to hospitalizations of older people, can be explained by idiosyncratic response or the predisposition of these patients to develop adverse drug events, whether or not drugs are classed as PIM. Key-words: potentially inappropriate medication (PIM), older people, adverse drug reaction (ADR), hospital admission, pharmacovigilance. PMID: 21733416 [PubMed - in process] (Source: J Pharm Pharm Sci)

No Difference Found In Thyroid Dysfunction Between Brand Name And Generic Versions Of Amiodarone

Health News from Medical News Today — Tue, 12 Jul 2011 08:00:00 +0100

There is no difference between brand-name and generic drug formulations of amiodarone - taken to control arrhythmia - in the incidence of thyroid dysfunction, according to a study in CMAJ (Canadian Medical Association Journal. Amiodarone, prescribed to control irregular heartbeats, is known for causing hypo- and hyper-thyroidism. Amiodarone is available in Canada in brand-name formulations as well as less costly generic versions. Generic formulations may be substituted if considered bioequivalent to the brand name drug... (Source: Health News from Medical News Today)

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Ranolazine effective for preventing post-CABG AF

MedWire News - Cardiology — Tue, 12 Jul 2011 00:00:00 +0100

Ranolazine is more effective than amiodarone for preventing atrial fibrillation after coronary artery bypass grafting, a study shows. (Source: MedWire News - Cardiology)

Adverse thyroid effects of generic and brand-name amiodarone similar

Modern Medicine — Mon, 11 Jul 2011 23:00:00 +0100

NEW YORK (Reuters Health) - The anti-arrhythmic drug amiodarone is linked with similar rates of thyroid effects whether patients take the brand-name drug or a generic, Canadian research shows. (Source: Modern Medicine)

Pulmonary disorders increased in AF patients taking amiodarone

Modern Medicine — Sun, 10 Jul 2011 23:00:00 +0100

NEW YORK (Reuters Health) - A new population-based study finds the incidence of pulmonary complications associated with amiodarone to be relatively low, but still 50% higher among patients with atrial fibrillation who take the antiarrhythmic drug than in those who do not. (Source: Modern Medicine)

Falling between the cracks: a case of amiodarone toxicity.

cmaj — Sun, 10 Jul 2011 23:00:00 +0100

Authors: Mackenzie C, Syed J, Pollak T, Koren G PMID: 21746823 [PubMed - as supplied by publisher] (Source: cmaj)

Amiodarone-induced thyroid dysfunction: brand-name versus generic formulations.

cmaj — Sun, 10 Jul 2011 23:00:00 +0100

Authors: Tsadok MA, Jackevicius CA, Rahme E, Essebag V, Eisenberg MJ, Humphries KH, Tu JV, Behlouli H, Joo J, Pilote L BACKGROUND: Amiodarone is associated with dysfunction of the thyroid. Concerns have arisen regarding the potential for adverse effects with generic formulations of amiodarone. We evaluated and compared the risk of thyroid dysfunction between patients using brand-name versus generic formulations of amiodarone and identified risk factors for thyroid dysfunction. METHODS: We conducted a retrospective cohort study of patients with atrial fibrillation aged 66 years and older. We used administrative databases that linked information on demographics and clinical characteristics, claims for prescription drugs and discharges from hospital. We estimated thyroid dysfunction using...

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Clinical characteristics of patients with asymptomatic recurrences of atrial fibrillation in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico–Atrial Fibrillation (GISSI-AF) trial

American Heart Journal — Thu, 07 Jul 2011 23:00:00 +0100

Conclusion: Asymptomatic AF recurrences were frequent in the GISSI-AF study population in patients who were more likely to develop persistent-permanent AF and were characterized by an increased thromboembolic risk. (Source: American Heart Journal)

Can Maintenance Amiodarone Be Given by IV Push?Can Maintenance Amiodarone Be Given by IV Push?

Medscape Today Headlines — Wed, 06 Jul 2011 14:28:00 +0100

What do you do when a patient needing oral amiodarone can't take oral medications? Medscape Pharmacists (Source: Medscape Today Headlines)

Safety of nerve conduction studies in patients with implantable cardioverter–defibrillators

Clinical Neurophysiology — Mon, 04 Jul 2011 04:00:00 +0100

Conclusions: Standardised test protocol for an NCS is safe in patients with an ICD regardless of the leads type.Significance: Current guidelines which limitate the NCS in patients with ICD may be the subject of revision. (Source: Clinical Neurophysiology)

Comparison of Effectiveness and Safety of Ranolazine Versus Amiodarone for Preventing Atrial Fibrillation After Coronary Artery Bypass Grafting

The American Journal of Cardiology — Sun, 03 Jul 2011 23:00:00 +0100

Atrial fibrillation (AF) is common after coronary artery bypass grafting (CABG) and increases the morbidity and cost. Amiodarone reduces AF after CABG. Ranolazine, an antianginal agent, also prolongs atrial refractoriness and inhibits after depolarizations and triggered activity; effects that could decrease AF after CABG. The present study compared amiodarone versus ranolazine for the prevention of AF after CABG. A retrospective cohort study of patients undergoing CABG at Aspirus Hospital from June 2008 to April 2010. The patients received either amiodarone (400 mg preoperatively followed by 200 mg twice daily for 10 to 14 days) or ranolazine (1,500 mg preoperatively followed by 1,000 mg twice daily for 10 to 14 days). The primary end point was any identified AF after CABG. A total of 393 ...