MedWorm: Amitriptyline

Antiallodynic Effect of Herbal Medicine Yokukansan on Peripheral Neuropathy in Rats with Chronic Constriction Injury

Advances in Pharmacological Sciences — Wed, 08 Feb 2012 18:37:00 +0100

In this study, we investigated the effects of yokukansan on neuropathic pain in chronic constriction injury (CCI) model. Oral administration of yokukansan significantly inhibited mechanical and cold allodynia in the von Frey hair or acetone test, respectively. In comparison, amitriptyline, a tricyclic antidepressant, demonstrated moderate, but not significant, antiallodynic effects in the mechanical and cold tests. Yokukansan significantly inhibited the cerebrospinal fluid dialysate level of glutamate that had increased by the stimulation of brush or acetone. Glutamate transporter inhibitors, DL-threo-beta-hydroxy aspartate and dihydrokainate, decreased the yokukansan-induced antiallodynic actions in CCI rats. Our results suggest that yokukansan was confirmed to have antiallodynic effects ...

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Horizon scanning: AmiKetT for peripheral neuropathic pain filed for FDA fast track designation

NeLM - News — Wed, 08 Feb 2012 05:00:00 +0100

Source: BioSpace Area: News According to a Biospace report, EpiCept has filed AmiKetT (amitriptyline 4%, ketamine 2% cream) for Fast Track designation with the U.S. Food and Drug Administration (FDA). AmiKetT is a prescription topical cream under late stage clinical development by EpiCept for the treatment of chemotherapy-induced peripheral neuropathic pain. (Source: NeLM - News)

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Med-Health Pharma, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 07 Feb 2012 05:00:00 +0100

Updated Date: Feb 7, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Cardinal Health]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 27 Jan 2012 05:00:00 +0100

Updated Date: Jan 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Prescription patterns of patients diagnosed with schizophrenia in mental hospitals in Tashkent/Uzbekistan and in four German cities

NeLM - Mental Health — Thu, 26 Jan 2012 05:00:00 +0100

Source: Pharmacoepidemiology and Drug Safety Area: Evidence > Medicines Management > References Purpose: Little is known about psychopharmacological prescription practice in low-income countries. The present study aimed for an analysis of pharmacological treatment strategies for inpatients with schizophrenia in Tashkent, the capital city of Uzbekistan, facing a low-income situation as compared with four German cities in a high-income Western situation. Methods: We conducted a cross-sectional quantitative survey of age, gender, diagnoses and psychotropic medication of 845 urban psychiatric inpatients of the Tashkent psychiatric hospital and of 922 urban psychiatric inpatients in four German cities on one day in Oct 2008. We compared the current treatment strategies fo...

Is magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?

Rheumatology International — Tue, 24 Jan 2012 06:53:32 +0100

Abstract The aims of this study were to investigate the relationship between magnesium levels and fibromyalgia symptoms and to determine the effect of magnesium citrate treatment on these symptoms. Sixty premenopausal women diagnosed with fibromyalgia according to the ACR criteria and 20 healthy women whose age and weight matched the premenopausal women were evaluated. Pain intensity, pain threshold, the number of tender points, the tender point index, the fibromyalgia impact questionnaire (FIQ), the Beck depression and Beck anxiety scores and patient symptoms were evaluated in all the women. Serum and erythrocyte magnesium levels were also measured. The patients were divided into three groups. The magnesium citrate (300 mg/day) was given to the first group (n =&...

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AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [STAT Rx USA LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 18 Jan 2012 05:00:00 +0100

Updated Date: Jan 18, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Herb-Drug Interactions and Mechanistic and Clinical Considerations.

Current Drug Metabolism — Wed, 18 Jan 2012 05:00:00 +0100

Authors: He SM, Sneed KB, Chen XW, Cao C, Zhou SF Abstract Herbal medicines are often used in combination with conventional drugs, and this may give rise to the potential of harmful herb-drug interactions. This paper updates our knowledge on clinical herb-drug interactions with an emphasis of the mechanistic and clinical consideration. In silico, in vitro, animal and human studies are often used to predict and/or identify drug interactions with herbal remedies. To date, a number of clinically important herb-drug interactions have been reported, but many of them are from case reports and limited clinical observations. Common herbal medicines that interact with drugs include St John's wort (Hypericum perforatum), ginkgo (Ginkgo biloba), ginger (Zingiber officinale), ginseng (Panax gi...

Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior.

Behavioural Brain Research — Tue, 17 Jan 2012 05:00:00 +0100

Authors: Peruga I, Hartwig S, Merkler D, Thöne J, Hovemann B, Juckel G, Gold R, Linker RA Abstract On a molecular level, depression is characterized by an altered monoaminergic neurotransmission as well as a modulation of cytokines and other mediators in the central nervous system. In particular, neurotrophic factors may influence affective behavior including depression and anxiety. Ciliary neurotrophic factor (CNTF) plays an important role in the regulation of neuronal development, neuroprotection and may also influence cognitive processes. Here we investigate the affective behavior in mice deficient for CNTF (CNTF -/- mice) at young age of 10-20 weeks. CNTF -/- mice displayed an increased anxiety-like behavior with a 30% reduction of the time spent in the bright compartment of t...

What Color is Your Urine?

The Poison Review — Thu, 05 Jan 2012 05:57:07 +0100

3.5 out of 5 stars Abnormal Urine Color. Aycock RD, Kass DA. South Med J 2012 Jan;105:43-47. Abstract This review article would be a good one to keep on file, since it provides a comprehensive review of drugs, foods, and medical conditions that can cause changes in urine color. There are many medical causes, such as hemolysis (red urine), porphyria (black urine), metastatic melanoma (brown urine). The following are the causes or abnormal urine color from medications or foods cited in the article: Red urine: chloroquine, deferoxamine, hydroxocobalamin, ibuprofen, phenazopyridine, rifampin, warfarin; beets, blackberries, carrots. Orange urine: isoniazid, riboflavin, sulfasalazine, plus any of the causes of red urine. Brown urine: acetaminophen (overdose0, metronidazole, niridazole, nitro...

Sildenafil, a phosphodiesterase type 5 inhibitor, enhances the antidepressant activity of amitriptyline but not desipramine, in the forced swim test in mice

Journal of Neural Transmission — Wed, 04 Jan 2012 06:57:58 +0100

In conclusion, the present study suggests that sildenafil may enhance the activity of antidepressant drugs which exhibit cholinolytic activity. Content Type Journal ArticleCategory Basic Neurosciences, Genetics and Immunology - Original ArticlePages 1-8DOI 10.1007/s00702-011-0756-9Authors Katarzyna Socała, Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, PolandDorota Nieoczym, Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, PolandElżbieta Wyska, Department of Pharmacokinetics and Physical Pharmacy, Collegium Medicum, Jagiellonian University, Kraków, PolandEwa Poleszak, Chair and Department of Applied Ph...

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AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 03 Jan 2012 05:00:00 +0100

Updated Date: Jan 3, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

House & Psychology, Episode 22

Psychology Today Depression Center — Thu, 29 Dec 2011 14:21:13 +0100

Ben: "We were in a fight. Doesn't mean she's depressed and it doesn't mean she doesn't love me."House: "Fine, maybe the diary proves nothing. On the other hand, half the country's on antidepressants. And it fits her symptoms perfectly." (Alone Season 4, Episode 1) Dear House, Really? You think "half the country's on antidepressants?" Primary Topic: Media read more (Source: Psychology Today Depression Center)

Diversion and abuse of buprenorphine: Findings from national surveys of treatment patients and physicians

Drug and Alcohol Dependence — Sat, 24 Dec 2011 06:11:24 +0100

Conclusions: The increases in diversion and abuse measures indicate the need to take active attempts to curb diversion and abuse as well as continuous monitoring and surveillance of all buprenorphine products. However, these increases parallel the increased number of tablets sold. Finding a balance of risk/benefit (i.e. diversion and abuse versus expanded treatment) remains a challenge. (Source: Drug and Alcohol Dependence)

Hypnotic Relaxation Vs Amitriptyline for Tension‐Type Headache: Let the Patient Choose

Headache: The Journal of Head and Face Pain — Wed, 21 Dec 2011 05:00:00 +0100

Conclusions.— HR treatment was a more popular choice among patients. Patients choosing HR reported greater symptom relief than those choosing AMT and were found to have greater treatment compliance. Patients receiving HR were less likely to change treatments. HR practiced by a neurologist is feasible in a standard neurological outpatient clinic setting; HR training should be considered for neurologists involved in headache treatment. (Source: Headache: The Journal of Head and Face Pain)

Hypnotic Relaxation Vs Amitriptyline for Tension-Type Headache: Let the Patient Choose.

Headache — Wed, 21 Dec 2011 05:00:00 +0100

Conclusions.- HR treatment was a more popular choice among patients. Patients choosing HR reported greater symptom relief than those choosing AMT and were found to have greater treatment compliance. Patients receiving HR were less likely to change treatments. HR practiced by a neurologist is feasible in a standard neurological outpatient clinic setting; HR training should be considered for neurologists involved in headache treatment. PMID: 22188357 [PubMed - as supplied by publisher] (Source: Headache)

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Pharmacologic interventions for treating phantom limb pain.

Cochrane Database of Systematic Reviews — Tue, 20 Dec 2011 01:00:04 +0100

CONCLUSIONS: The short- and long-term effectiveness of opioids, NMDA receptor antagonists, anticonvulsants, antidepressants, calcitonins, and anaesthetics for clinically relevant outcomes that include pain, function, mood, sleep, quality of life, satisfaction and adverse effects remains unclear. Morphine, gabapentin and ketamine demonstrate trends towards short-term analgesic efficacy. Memantine and amitriptyline were ineffective for PLP. Results, however, are to be interpreted with caution as these were based mostly on a small number of studies with limited sample sizes that varied considerably and also lacked long-term efficacy and safety outcomes. The direction of efficacy of calcitonin, anaesthetics and dextromethorphan need further clarification. Larger and more rigorous randomised co...

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [H.J. Harkins Company, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 19 Dec 2011 05:00:00 +0100

Updated Date: Dec 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 13 Dec 2011 05:00:00 +0100

Updated Date: Dec 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Detection of Amitriptyline, Citalopram, and Metabolites in Porcine Bones Following Extended Outdoor Decomposition*

Journal of Forensic Sciences — Thu, 08 Dec 2011 05:00:00 +0100

Authors: Desrosiers NA, Watterson JH, Dean D, Wyman JF Abstract Skeletal remains of a domestic pig were assessed for relative distribution of amitriptyline, citalopram, and metabolites. Following acute exposure and outdoor decomposition for 2 years, drugs and metabolites were analyzed in 13 different bones. Bones were pulverized following a simple wash procedure, and drugs were extracted by passive incubation in methanol, followed by solid-phase extraction. Samples were analyzed by ultra-high performance liquid chromatography (UHPLC) and confirmed with gas chromatography-mass spectrometry. The Kruskall-Wallis test showed that bone type was a main effect with respect to drug level for all analytes, with levels varying from 33- to 166-fold. Ratios of levels of drug to that of t...

AMITRIPTYLINE HYDROCHLORIDEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 06 Dec 2011 05:00:00 +0100

Updated Date: Dec 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Effect of Low‐Dose Amitriptyline on Autonomic Functions and Peripheral Blood Flow in Fibromyalgia: A Pilot Study

Pain Medicine — Mon, 05 Dec 2011 05:00:00 +0100

Conclusion. Amitriptyline therapy (10 mg for 3 months) increases blood flow to the affected sites. It does not affect autonomic tone and reactivity in the patients with fibromyalgia. (Source: Pain Medicine)

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 02 Dec 2011 05:00:00 +0100

Updated Date: Dec 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Amitriptyline overdose: Status epilepticus in a child following chronic inadvertent overdosing: case report

Reactions — Thu, 01 Dec 2011 07:29:01 +0100

(Source: Reactions)

Treatment with paroxetine, but not amitriptyline, lowers levels of lipoprotein(a) in patients with major depression

Journal of Psychopharmacology — Thu, 01 Dec 2011 05:00:00 +0100

High lipoprotein(a) (Lp(a)) levels constitute a major risk factor for vascular mortality. Major depression also increases the risk of cardiovascular disease. We measured the concentrations of Lp(a) in depressed patients and controls and studied the effects of antidepressant treatment and treatment outcome. Lp(a) levels were analysed at baseline in 35 in-patients with DSM-IV major depression who were then treated in a randomized double-blind manner with amitriptyline (n = 14) or paroxetine (n = 21), as well as in 33 healthy controls. Lp(a) levels were re-assessed after 4 weeks of treatment. We found a significant decrease in Lp(a) in patients treated with paroxetine, but not in those treated with amitriptyline. Our results suggest that antidepressant treatment with paroxetine might contribu...

Posttraumatic Headache in Military Personnel and Veterans of the Iraq and Afghanistan Conflicts

Current Treatment Options in Neurology — Thu, 24 Nov 2011 17:45:03 +0100

Opinion statement Headaches, particularly migraine, are common in US servicemembers (SMs) who are deployed to or have returned from theaters of combat operations in Iraq and Afghanistan. Concussions and exposure to explosive blasts may be a significant contributor to the increased prevalence of headaches in military veterans. Concussions, usually due to blast exposure, occur in approximately 20% of deployed SMs, and headaches are a common symptom after a deployment-related concussion. Posttraumatic headaches (PTHAs) in US SMs usually resemble migraines, and posttraumatic stress disorder (PTSD) and depression are common comorbidities. Treatment of PTHAs in SMs is based upon the treatment setting, whether the headaches are acute or chronic, the headache phenotype, and associ...

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Amitriptyline/gabapentin/pregabalin: Falls, dizziness and drowsiness in elderly patients: 3 case reports

Reactions — Wed, 16 Nov 2011 21:59:42 +0100

(Source: Reactions)

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 16 Nov 2011 05:00:00 +0100

Updated Date: Nov 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Systematic Review and Meta-Analysis of Efficacy, Safety, and Tolerability Data from Randomized Controlled Trials of Drugs Used to Treat Postherpetic Neuralgia (December).

The Annals of Pharmacotherapy — Tue, 15 Nov 2011 05:00:00 +0100

CONCLUSIONS:While available literature establishes the efficacy of 8 drugs in treatment of PHN, it does not provide adequate guidance as to which agents are best to treat this condition, in part because of inadequate reporting of data on tolerability and safety. PMID: 22085778 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 14 Nov 2011 05:00:00 +0100

Updated Date: Nov 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 14 Nov 2011 05:00:00 +0100

Updated Date: Nov 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 14 Nov 2011 05:00:00 +0100

Updated Date: Nov 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 08 Nov 2011 05:00:00 +0100

Updated Date: Nov 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Is Serum S100B Protein a Biomarker for Amitriptyline-Induced Cardiovascular Toxic Effects?

Cardiovascular Toxicology — Fri, 04 Nov 2011 04:00:00 +0100

Authors: Hocaoglu N, Kalkan S, Buyukdeligoz M, Oransay K, Tuncok Y Abstract The aim of this study was to assess the role of serum S100B protein as a biomarker for cardiovascular effects in an anesthetized rat model of amitriptyline toxicity. Adult male Wistar rats (n = 28) were randomized into four groups. While the control group received normal saline, the experimental groups received different doses of amitriptyline (0.625 or 0.94 or 1.25 mg/kg/min) infusion. Mean arterial pressure (MAP), heart rate (HR), electrocardiogram parameters, and serum S100B protein levels were recorded during the experiment. Linear Pearson's correlation coefficient was used to examine the association between cardiovascular parameters and serum levels of S100B protein. In the experimental groups, amit...

Medication Use and Functional Status Decline in Older Adults: A Narrative Review.

The American Journal of Geriatric Pharmacotherapy — Fri, 04 Nov 2011 04:00:00 +0100

CONCLUSIONS: Benzodiazepines and anticholinergics have been consistently associated with impairments in functional status in the elderly. The relationships between suboptimal prescribing, antidepressants, and antihypertensives and functional status decline were mixed. Further research using established measures and methods is needed to better describe the impact of medication use on functional status in older adults. PMID: 22057096 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy)

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Treatment of Meralgia Paresthetica with Ultrasound‐Guided Pulsed Radiofrequency Ablation of the Lateral Femoral Cutaneous Nerve

Pain Practice — Tue, 01 Nov 2011 04:00:00 +0100

Abstract: A 23‐year‐old female with an 18‐month history of left anterolateral thigh paresthesias and burning pain consistent with meralgia paresthetica was referred to our clinic after failing trials of physical therapy, nonsteroidal anti‐inflammatories, gabapentin, and amitriptyline. We performed 3 lateral femoral cutaneous nerve blocks with corticosteroid over a 4‐month period; however, each block provided only temporary relief. As this pain was limiting the patient’s ability to perform her functions as an active duty service member, we elected to perform a pulsed radiofrequency treatment of the lateral femoral cutaneous nerve with ultrasound guidance and nerve stimulation. After locating the lateral femoral cutaneous nerve with ultrasound and reproducing the patient’s d...

Ionic and Cellular Mechanisms Underlying the Development of Acquired Brugada Syndrome in Patients Treated with Antidepressants

Journal of Cardiovascular Electrophysiology — Fri, 28 Oct 2011 04:00:00 +0100

Conclusions:Our data suggest that amitriptyline‐induced inhibition of INa unmasks the Brugada ECG phenotype and facilitates development of an arrhythmogenic substrate only in the setting of a genetic predisposition by creating repolarization heterogeneities that give rise to phase 2 reentry and VT.(J Cardiovasc Electrophysiol, Vol. pp. 1‐10) (Source: Journal of Cardiovascular Electrophysiology)

No Antidotal Effect of Intravenous Lipid Emulsion in Experimental Amitriptyline Intoxication despite Significant Entrapment of Amitriptyline

Basic and Clinical Pharmacology and Toxicology — Wed, 26 Oct 2011 13:07:58 +0100

In conclusion, a marked entrapment of amitriptyline by intravenous lipid emulsion was observed but this did not improve the pigs’ haemodynamic recovery from severe amitriptyline intoxication. Care should be exercised in the antidotal use of lipid emulsion until controlled human studies indicate its efficacy and safety. (Source: Basic and Clinical Pharmacology and Toxicology)

Effectiveness of cognitive-behavioral therapy and amitriptyline in patients with chronic temporomandibular disorders: a pilot study.

Braz Dent J — Wed, 26 Oct 2011 07:40:03 +0100

Authors: Calderon Pdos S, Tabaquim Mde L, Oliveira LC, Camargo AP, Ramos Netto Tde C, Conti PC Abstract The aim of this pilot study was to evaluate the effectiveness of cognitive-behavioral therapy (CBT) and use of amitriptyline, a tricyclic antidepressant, in patients with chronic temporomandibular disorders (TMD). Forty-seven women (mean age = 35.4 years old) with chronic TMD were enrolled in the study and divided into 4 groups: amitriptyline; amitriptyline and CBT; placebo and CBT; and placebo only (control). Patients were managed for 7 consecutive weeks. Follow-up evaluations were done at the 1st, 7th and 11th weeks of treatment. The presence and severity of pain, levels of depression, and quality of life and sleep were measured. Data were analyzed using ANOVA, Chi-square and C...

Re: Bladder Pain Syndrome Treated With Triple Therapy With Gabapentin, Amitriptyline, and a Nonsteroidal Anti-Inflammatory Drug

The Journal of Urology — Wed, 26 Oct 2011 04:00:00 +0100

J. W. Lee, D. Y. Han and H. J. Jeong Department of Urology and Institute of Wonkwang Medical Sciences, Wonkwang University School of Medicine, Iksan, Korea (Source: The Journal of Urology)

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Report of cases in patients with acute herpetic neuralgia using a Mangifera indica extract

Revista Brasileira de Farmacognosia — Sat, 22 Oct 2011 05:55:24 +0100

It has been accepted that neuroinflammation, oxidative stress and glial activation are involved in the central sensitization underlying neuropathic and inflammatory pain. Vimang® is the brand name of an aqueous extract of Mangifera indica L., Anacardiaceae, traditionally used in Cuba for its antioxidant, antiinflammatory, analgesic, and immunomodulatory properties. In the present study, we determined the possible effects of Vimang formulations in acute herpes zoster (n=12) patients, that received a daily dose of 1800 mg of extract (two coated Vimang tablets, 300 mg each, three times daily before meals) associated to low doses of amitriptyline (10-25 mg/d). In addition to the tablets, they utilized compresses containing Vimang dissolution at 2% on skin lesions for thirty days. The average ...

Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report

Clinical and Developmental Immunology — Mon, 17 Oct 2011 22:54:41 +0100

A multimodal stepped care approach has been successfully applied to a patient with complex regional pain syndrome type 1 and severe intractable pain, not responding to regular neuropathic pain medication. The choice to administer drugs in creams was made because of the intolerable adverse effects to oral medication. With this method, peak-dose adverse effects did not occur. The multimodal stepped care approach resulted in considerable and clinically relevant decrease in pain after every step, using topical amitriptyline, ketamine, and dimethylsulphoxide. (Source: Clinical and Developmental Immunology)

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 13 Oct 2011 05:00:00 +0100

Updated Date: Oct 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Dispensing Solutions, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 07 Oct 2011 05:00:00 +0100

Updated Date: Oct 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The use of antidepressants for headache prophylaxis.

CNS Neuroscience and Therapeutics — Sat, 01 Oct 2011 04:00:00 +0100

Authors: Smitherman TA, Walters AB, Maizels M, Penzien DB Abstract The focus of this review is on the efficacy of antidepressants as preventive treatments for migraine and chronic tension-type headache (TTH). Pharmacologic prophylaxis may be indicated for patients with frequent headaches, who respond insufficiently to acute therapies, or for whom medication overuse is a concern. The well-documented efficacy of the tricyclic antidepressant amitriptyline, both for migraine and chronic TTH, has been followed by widespread use of other antidepressants for headache prophylaxis. Although antidepressants in general share comparable efficacy for the treatment of depressive disorders, their efficacy as headache preventives varies widely. Evidence supporting use of the selective serotonin re...

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ToF-SIMS analysis of ocular tissues reveals biochemical differentiation and drug distribution.

European Journal of Pharmaceutics and Biopharmaceutics — Sat, 01 Oct 2011 04:00:00 +0100

This study demonstrates that PCA can be successfully applied to ToF-SIMS data from different ocular tissues and highlights the potential of coupling multivariate statistics with surface analytical techniques to gain a greater understanding of the biochemical composition of tissues and the distribution of pharmaceutically active small molecules within these tissues. PMID: 21540110 [PubMed - in process] (Source: European Journal of Pharmaceutics and Biopharmaceutics)

Therapeutic plasma exchange in amitriptyline intoxication: Case report and review of the literature

Transfusion and Apheresis Science — Sat, 01 Oct 2011 04:00:00 +0100

We present a case of severe amitriptyline poisoning successfully treated with plasma exchange. Due to high plasma protein binding property of amitriptyline, plasma exchange therapy should be considered in cases of severe amitriptyline intoxication as a life saving therapeutic modality. (Source: Transfusion and Apheresis Science)

Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants

Molecular Pain — Wed, 21 Sep 2011 04:00:00 +0100

Conclusions: These results suggest that the repetitive intrathecal administration of antidepressants permanently cures ICS-induced FM pain in mice. (Source: Molecular Pain)

Clinical Herbal Interactions with Conventional Drugs: From Molecules to Maladies.

Current Medicinal Chemistry — Thu, 15 Sep 2011 04:00:00 +0100

Authors: Chen XW, Serag ES, Sneed KB, Liang J, Chew H, Pan SY, Zhou SF Abstract Clinical studies and case reports have identified a number of herb-drug interactions potentiated by the concurrent use of herbal medicines with prescription drugs. The purpose of this paper is to discuss the mechanisms and clinical implications of such herb-drug interactions by reviewing published human studies. Both pharmacokinetic and pharmacodynamic components may be involved in herbdrug interactions, although metabolic induction or inhibition is a common underlying mechanism for many herb-drug interactions. Drugs that have a high potential to interact with herbal medicines usually have a narrow therapeutic index, including warfarin, digoxin, cyclosporine, tacrolimus, amitriptyline, midazolam, indina...

Primary Stabbing “Ice-Pick” Headache

Pediatric Neurology — Tue, 13 Sep 2011 03:39:28 +0100

Abstract: Primary stabbing “ice-pick” headache is rarely reported in children. It is characterized by transient, sharp stabbing pain that occurs within a localized area of the scalp for seconds. Five children were diagnosed according to the International Classification of Headache Disorders Diagnostic Criteria, Second Edition. Ages at diagnosis ranged from 6-16 years (mean age, 9.8 years), with signs lasting for 3-12 months (mean, 6.5 months) before assessment. All children presented with recurrent daily to monthly headaches that were very brief, lasting for seconds. The headache was orbital in one child, temporal in one child, and occipital in three children. Three children manifested other associated migraine headache types, and two had a positive family history of migraine. Amitript...

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NICE proposes changes to first-line treatment recommendations for neuropathic pain

NeLM - News — Mon, 12 Sep 2011 04:00:00 +0100

Source: NICE Area: News NICE is consulting on proposed changes to some of the recommendations made in its clinical guideline on the pharmacological management of neuropathic pain in adults in non-specialist settings (CG 96; March 2010). This action follows concerns about the associated costs that pregabalin may bring to the NHS as one of the first line treatment options for adults with neuropathic pain, and considers new evidence regarding the first-line treatment options. The draft guideline containing amended recommendations is now available for consultation; registered stakeholders are invited to make comments on the provisional recommendations via the website (the consultation closes at 9am on 10th October 2011). The main recommendations regarding fir...

Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats

Neurological Sciences — Sat, 10 Sep 2011 05:45:49 +0100

Abstract The aim of the present study was to develop a new experimental pain model by adapting the chronic constriction injury (CCI) model of the sciatic nerve to the exclusively sensory saphenous nerve in rats. Animals were divided into naïve, sham, and two experimental groups, in which two or four 4-0 chromic gut ligatures were loosely ligated around the saphenous nerve. Then, behavioral signs of neuropathic pain were observed for 8 weeks. In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures. Pharmacological analysis was made in rats with four loose ligations; morphine and WIN 55,212-2, a cannabinoid agonist, reversed all of the modalities tested, whereas...

T234 evaluation of cr, in comparison with gabapentin and amitriptyline, in a rat model of fibromyalgia

European Journal of Pain Supplements — Thu, 01 Sep 2011 04:00:00 +0100

(Source: European Journal of Pain Supplements)

F117 electroacupuncture produces antinociception in nonresponder rats treated with intraperitoneal amitriptyline

European Journal of Pain Supplements — Thu, 01 Sep 2011 04:00:00 +0100

(Source: European Journal of Pain Supplements)

F230 comparison between quetiapine-xr and amitriptyline in fibromyalgia patients: a 16-week, randomized, open-label, non-inferiority trial

European Journal of Pain Supplements — Thu, 01 Sep 2011 04:00:00 +0100

(Source: European Journal of Pain Supplements)

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F629 does long-term administration of amitriptyline or morphine reduce neuropathic pain in a rodent model? – a placebo controlled study

European Journal of Pain Supplements — Thu, 01 Sep 2011 04:00:00 +0100

(Source: European Journal of Pain Supplements)

Amitriptyline/clozapine interaction: Fatal interstitial pneumonitis in an elderly patient: case report

Reactions — Sat, 27 Aug 2011 15:26:04 +0100

(Source: Reactions)

Topical amitriptyline, ketamine, and lidocaine in neuropathic pain caused by radiation skin reaction: a pilot study

Supportive Care in Cancer — Wed, 17 Aug 2011 05:54:57 +0100

Conclusions AKL was a safe intervention to use with minimal toxicity and good compliance. It significantly reduced several measures of neuropathic pain associated with radiation dermatitis. A larger-scale study would require recruitment from multiple centers. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s00520-011-1240-7Authors Isabella Uzaraga, Radiation Therapy Program, Vancouver Island Centre, BC Cancer Agency, Vancouver, BC, CanadaBev Gerbis, Radiation Therapy Program, Vancouver Island Centre, BC Cancer Agency, Vancouver, BC, CanadaEleanor Holwerda, Radiation Therapy Program, Vancouver Island Centre, BC Cancer Agency, Vancouver, BC, CanadaDan Gillis, University of Guelph School of Computer Science, Guelph, ON, CanadaElaine Wai, Radia...

High degree of efficacy in the treatment of cyclic vomiting syndrome with combined co-enzyme Q10, L-carnitine and amitriptyline, a case series

BMC Neurology — Mon, 15 Aug 2011 23:00:00 +0100

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Treatment of medication overuse headache – guideline of the EFNS headache panel

European Journal of Neurology — Fri, 12 Aug 2011 21:07:24 +0100

Discussion and conclusion: Medication overuse headache can be treated according to evidence‐based recommendations. (Source: European Journal of Neurology)

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SENTRAVIL PM-25 (Amitriptyline Hydrochloride, Choline) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 12 Aug 2011 05:00:00 +0100

Updated Date: Aug 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Cardinal Health]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 08 Aug 2011 05:00:00 +0100

Updated Date: Aug 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain

Neuropeptides — Mon, 08 Aug 2011 04:00:00 +0100

Abstract: Evidence suggests that nerve growth factor (NGF) may have antidepressant properties but the pharmacological mechanisms remain unknown. Previously, we found that NGF improved performance in the forced swim test in Flinders Sensitive Line rats, but did not appear to have similar biochemical actions with the antidepressant fluoxetine. Gene expression profiles for neurotransmitter receptors and regulator-related genes in the amygdala/hippocampus were determined in rats treated for 14days with NGF, fluoxetine, amitriptyline, or saline. Gene expression was measured using an RT2 profiler PCR Array System to determine the basis for this effect. Compared with saline, there were numerous genes with significantly altered mRNA levels in the amygdala/hippocampal region. Overlap was found betw...

Higher doses of opioids in patients who need palliative sedation prior to death: Cause or consequence?

European Journal of Cancer — Thu, 28 Jul 2011 04:00:00 +0100

Conclusions: Our findings support the hypothesis that, although pain was not the main indication for PS, pain and its treatment might have been primarily related to the need for palliative sedation in this patient cohort. (Source: European Journal of Cancer)

Antidepressants and the risk of sudden cardiac death and ventricular arrhythmia

Pharmacoepidemiology and Drug Safety — Wed, 27 Jul 2011 23:00:00 +0100

ConclusionsOf antidepressants studied, only mirtazapine had a statistically significantly greater SD/VA risk versus paroxetine. However, baseline differences between these users suggest that this finding may be attributable to residual confounding. Eleven other antidepressants had SD/VA risks no greater than that of paroxetine, thereby providing reassurance regarding the comparative cardiovascular safety of antidepressants. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

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Does horny goat weed have any clinically significant interactions?

NeLM - Medicines Q and A — Wed, 27 Jul 2011 23:00:00 +0100

Source: Regional Drug and Therapeutics Centre Area: Evidence > Medicines Q & A Horny goat weed (Epimedium) is a herbal medicine that may comprise mixtures of different related Epimedium species, which contain numerous and varied active constituents. As herbal products are subject to variations in quality, safety and efficacy, their use should not be recommended routinely. There is no published human information on drug interactions with horny goat weed, but the potential for interactions exists, as horny goat weed has been shown in vitro to inhibit a number of cytochrome P450 enzymes. Drugs which may be affected include warfarin, amitriptyline, clarithromycin, erythromycin, ciclosporin, tacrolimus, and phenytoin. This Medicines Q&A explores the possibility ...

A Comparative Efficacy of Amitriptyline, Gabapentin, and Pregabalin in Neuropathic Cancer Pain: A Prospective Randomized Double-Blind Placebo-Controlled Study

Palliative Care JournalClub - Selected Articles — Mon, 25 Jul 2011 12:06:17 +0100

Am J Hosp Palliat Care (new issue) (Source: Palliative Care JournalClub - Selected Articles)

The Interaction Between Antidepressant Drugs and the Pain-Relieving Effect of Spinal Cord Stimulation in a Rat Model of Neuropathy.

Anesthesia and Analgesia — Sun, 24 Jul 2011 23:00:00 +0100

Conclusions: These findings suggest a possible clinical application with a combination of SCS and a tricyclic antidepressant or selective serotonin/noradrenaline reuptake inhibitor drug in cases in which SCS per se has proven inefficient. PMID: 21788322 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)

Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline.

Neuropharmacology — Thu, 21 Jul 2011 23:00:00 +0100

This article is part of a Special Issue entitled 'Anxiety and Depression'. PMID: 21803057 [PubMed - as supplied by publisher] (Source: Neuropharmacology)

Amitriptyline overdose: Hypotension treated with terlipressin: case report

Reactions — Wed, 20 Jul 2011 16:58:58 +0100

(Source: Reactions)

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Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double‐blind placebo‐controlled study

Alimentary Pharmacology and Therapeutics — Mon, 18 Jul 2011 23:00:00 +0100

Conclusions Amitriptyline did not affect drinking capacity and postprandial symptoms evoked by the drink test in FD patients. However, total clinical symptom score and nausea were reduced during 8 weeks of treatment. Our data suggest that amitriptyline particularly improves nausea in functional dyspepsia, but larger clinical trials are needed to further confirm our findings. (Source: Alimentary Pharmacology and Therapeutics)

Pharmacotherapy of Borderline Personality: Medicine or Mayhem

Psychology Today Personality Center — Mon, 18 Jul 2011 00:00:36 +0100

When are medications helpful in treating Borderline Personality?read more (Source: Psychology Today Personality Center)

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 15 Jul 2011 05:00:00 +0100

Updated Date: Jul 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Behavioural phenotyping of knockout mice for the sigma-1 ({sigma}1) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations

Journal of Psychopharmacology — Thu, 14 Jul 2011 23:00:00 +0100

The sigma-1 (1) protein regulates calcium homeostasis and acts as an endoplasmic reticulum chaperone. It can be activated by ligands which impact memory, depression, anxiety or addiction processes. We here characterized the behavioural phenotype of knockout (KO) mice for the 1 protein. Two-month old male 1 –/– mice showed signs of anxiety in the open-field, passive avoidance or elevated plus-maze test, but other activity or memory responses were unchanged. Female 1 –/– mice showed deficits in spontaneous alternation or water-maze learning. Twelve-month old 1 +/– female mice showed deficits in alternation and 1 –/– mice in avoidance escape latency. Two- and 14-month old female 1 –/– mice showed decrease...

Hyperaesthesia following genital herpes: a case report.

Herpes — Wed, 13 Jul 2011 17:45:03 +0100

We report an adult female patient who presented with sacral radiculopathy as incapacitating dysthesias following primary genital herpes simplex, which later recurred. Despite use of systemic antiviral treatment, the painful syndrome in our patient persisted. The success in treatment was seen only after the addition of amitriptyline hydrochloride. The case is being presented here for its rare manifestation and novel use of amitriptyline hydrochloride. PMID: 21747842 [PubMed - in process] (Source: Herpes)

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Safety assessment of potentially inappropriate medications use in older people and the factors associated with hospital admission.

J Pharm Pharm Sci — Tue, 12 Jul 2011 15:30:03 +0100

Conclusion: PIM use in elderly people is not a risk factor for ADR-related hospital admission. Probably, severe ADR, which lead to hospitalizations of older people, can be explained by idiosyncratic response or the predisposition of these patients to develop adverse drug events, whether or not drugs are classed as PIM. Key-words: potentially inappropriate medication (PIM), older people, adverse drug reaction (ADR), hospital admission, pharmacovigilance. PMID: 21733416 [PubMed - in process] (Source: J Pharm Pharm Sci)

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 12 Jul 2011 05:00:00 +0100

Updated Date: Jul 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Gallbladder Emptying in Patients with Major Depression: A Case Series

Pharmacopsychiatry — Mon, 11 Jul 2011 23:00:00 +0100

Discussion: In patients with cholecystitis, it would be wise to use antidepressants which do not impair gallbladder emptying, like maprotiline or fluoxetine, and to avoid amitriptyline.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)

A Comparative Efficacy of Amitriptyline, Gabapentin, and Pregabalin in Neuropathic Cancer Pain: A Prospective Randomized Double-Blind Placebo-Controlled Study.

The American Journal of Hospice and Palliative Care — Sat, 09 Jul 2011 23:00:00 +0100

Authors: Mishra S, Bhatnagar S, Nirvani Goyal G, Pratap Singh Rana S, Upadhya SP Neuropathic pain is difficult to diagnose and difficult to treat with certainty. So the aim of the study was to evaluate comparative clinical efficacy of pregabaline with amitriptyline and gabapentin in neuropathic cancer pain. A total of 120 patients with cancer having severe neuropathic cancer pain were enrolled in the study after taking approval from Institutional Ethics Committee and divided in to 4 groups: group AT-amitriptyline, group GB-gabapentin, group PG-pregabalin, and group PL-placebo. Oral morphine was used for rescue analgesic for continued pain. Pain score (Visual Analogue scale) and secondary outcome measures such as intensity of lancinating, dysesthesia, and burning on numerical rating sca...

Drug interactions in palliative care - it's more than cytochrome P450.

Palliative Medicine — Wed, 06 Jul 2011 23:00:00 +0100

CONCLUSION: Most relevant drug interactions can be expected with: (i) drugs (inter-) acting via histamine, acetylcholine or dopamine receptors; and (ii) Non-steroidal anti-inflammatory drugs. Even in last hours of life the combination of substances (e.g. anticholinergics) may produce relevant drug interactions (e.g. delirium). Perspective: Data on the potential for drug-drug interactions in palliative case is extremely scarce, but drug interactions can be limited if a few facts are considered. A synopsis of the findings of these studies is presented as concise recommendation to minimize drug interactions. PMID: 21737479 [PubMed - as supplied by publisher] (Source: Palliative Medicine)

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AMITRIPTYLINE HYDROCHLORIDE (Amitriptyline Hydrochloride) Tablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 05 Jul 2011 05:00:00 +0100

Updated Date: Jul 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Tox Tunes #47: Cocaine Blues (Nick Drake)

The Poison Review — Mon, 04 Jul 2011 18:08:31 +0100

www.youtube.com/watch?v=wY8YaLQ8H74 Nick Drake (1948-1974) released only 3 albums in his short career. This early home-recorded version of “Cocaine Blues” can be found on the posthumously-released compilation Family Tree. Although he developed a cult following in the British folk-music scene in the early 1970s, he never achieved real fame or popularity until 2000 when his song “Pink Moon” was used in a Volkswagen commercial. Throughout his career, Drake suffered from severe depression, no doubt exacerbated by his use of what was described as “unbelievable amounts of marijuana”. On November 23, 1974, he died of an acute amitriptyline overdose. Here’s the Volkswagen commercial: www.youtube.com/watch?v=BIOW9fLT9eY Related posts: Tox Tunes #4...

Nontricyclic antidepressant analgesics and pain: Are serotonin norepinephrine reuptake inhibitors (SNRIs) any better?

Pain — Mon, 04 Jul 2011 04:00:00 +0100

Almost 50years of clinical investigation has resulted in a large amount of literature regarding pain and antidepressants, one of the first categories of drugs found effective for chronic noncancer pain (CNCP) by randomized controlled trials (RCTs). These RCTs first examined tricyclic antidepressants (TCAs) based on published observational data and the rationale that their actions potentiated descending pain-inhibitory brainstem mechanisms involving serotonin and noradrenaline . Attention turned to more selective antidepressants as they were developed because of limitations in efficacy and concern about adverse effects. These were initially the selective serotonin reuptake inhibitors (SSRIs) (fluoxetine and congeners) and the more noradrenergic agents (the tetracyclic antidepressant maproti...

Amitriptyline overdose: Heart arrest, seizures and coma treated with soya oil emulsion: case report

Reactions — Sun, 03 Jul 2011 18:34:01 +0100

(Source: Reactions)

Amitriptyline/citalopram/mirtazapine: Fatal serotonin syndrome: 2 case reports

Reactions — Sun, 03 Jul 2011 18:34:01 +0100

(Source: Reactions)

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Prescription patterns of patients diagnosed with schizophrenia in mental hospitals in Tashkent/Uzbekistan and in four German cities

Pharmacoepidemiology and Drug Safety — Thu, 30 Jun 2011 23:00:00 +0100

ConclusionsIn both settings, psychotropic combination treatments are common for the treatment of schizophrenia contrasting current guideline recommendations. Its rationale and effectiveness needs to be tested in further studies. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

The Cochrane Library and the Treatment of Chronic Abdominal Pain in Children and Adolescents: An Overview of Reviews

Evidence-Based Child Health: A Cochrane Review Journal — Thu, 30 Jun 2011 23:00:00 +0100

ConclusionsThe successful management of chronic abdominal pain requires a comprehensive, multifaceted approach. The current evidence, albeit limited, suggests that CBT may be effective and that refocusing the patient and family on coping strategies as well as emphasizing normal childhood functioning can have positive results. As such, psychological treatments such as CBT look promising for the treatment of childhood chronic abdominal pain. If pharmacological interventions are considered, current evidence may support a trial of amitriptyline for adolescents with irritable bowel syndrome. However, both of these conclusions are based on a small number of short‐duration trials that are at high or unclear risk of bias. Overall, conclusive evidence is lacking to support dietary, pharmacologica...

Implications of current clinical trials focused on medication overuse and therapeutic prophylaxis.

Headache — Thu, 30 Jun 2011 23:00:00 +0100

Authors: Aurora SK (Headache 2011;51;S2:93-100) Chronic migraine (CM) is a complex disorder requiring a multifaceted management approach encompassing lifestyle modification, trigger avoidance, behavioral therapy, pharmacotherapy, patient education and support, management of expectations, and close follow-up. The lack of pharmacotherapies approved by the US Food and Drug Administration (FDA) hinders CM prophylaxis and management. Topiramate, gabapentin, tizanidine, fluoxetine, amitriptyline, and onabotulinumtoxinA have been evaluated for prophylactic treatment of CM in randomized, double-blind, placebo-controlled or active comparator-controlled trials. Additional well-designed, placebo-controlled studies are needed to assess the effectiveness of new and existing treatment options for CM...

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [UDL Laboratories, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 27 Jun 2011 05:00:00 +0100

Updated Date: Jun 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Anticholinergic side effect of many drugs linked with increased health risks for over 65s

NeLM - Care of Older People — Thu, 23 Jun 2011 23:00:00 +0100

Source: Journal of the American Geriatrics Society, BBC Health News Area: News Research funded by the Medical Research Council (MRC) - the Cognitive Function and Ageing Studies (CFAS) project - has found that anticholinergic activity, an adverse effect of many commonly used medicines, appears to increase the risks of both cognitive brain impairment and death in older people. Groups of medicines with the greatest impact include: anti-depressants such as amitriptyline, imipramine and clomipramine; antipsychotics such as chlorpromazine and trifluoperazine; anti-muscarinic medication such as oxybutynin; and antihistamines such as chlorphenamine. CFAS is a large, multi-centre initiative being led by the University of East Anglia (UEA). It was launched over 20 years ago to examine he...

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CHLORDIAZEPOXIDE AND AMITRIPTYLINE HCL (Chlordiazepoxide And Amitriptyline Hydrochloride) Tablet [Par Pharmaceutical Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 22 Jun 2011 05:00:00 +0100

Updated Date: Jun 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 20 Jun 2011 05:00:00 +0100

Updated Date: Jun 20, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMITRIPTYLINE HYDROCHLORIDE (Amitriptyline Hydrochloride) Tablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 17 Jun 2011 05:00:00 +0100

Updated Date: Jun 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 16 Jun 2011 05:00:00 +0100

Updated Date: Jun 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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High Doses of Topical Amitriptyline in Neuropathic Pain: Two Cases and Literature Review

Pain Practice — Wed, 15 Jun 2011 23:00:00 +0100

Abstract: Severe chronic neuropathic pain is a challenge to treat, and due to adverse effects of classical oral medication, optimal and effective dose levels are difficult to reach. Therefore, administration of topical analgesics might be an option, due to reduced adverse effects, and increased patient compliance.The aim of this article is to describe two cases treated effectively with topical amitriptyline 5% and 10%, the highest dosage described to date. The first patient was a 39‐year‐old man, suffering from severe intractable neuropathic pain in feet and hands, due to diabetes mellitus type II (DM‐II). After application of amitriptyline 5% the patient experienced a complete relieve only in the hands, whereas after application of amitriptyline 10%, a total reduction of pain occ...

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Preferred Pharmaceuticals, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 13 Jun 2011 05:00:00 +0100

Updated Date: Jun 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antidepressants encounter autophagy in neural cells.

Autophagy — Fri, 10 Jun 2011 11:54:17 +0100

Authors: Zschocke J, Rein T The prevailing view of antidepressants' (ADs) mode of action primarily focuses on their impact on neurotransmitter circuits, since the corresponding transporters and receptors are common targets of ADs. However, mounting evidence points to additional target structures, which may either support the beneficial effects or account for undesired side-effects of ADs. Recently, we analyzed the influence of three ADs of different classes on autophagy-related processes in primary astrocytes and neurons. While amitriptyline (AMI) and citalopram (CIT) upregulates the expression of autophagic markers such as LC3B-II or Beclin 1, venlafaxine fails to exert these effects. Autophagy triggered by AMI and CIT is functional in terms of autophagic flux, and is partially mediat...

New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio

Journal of Neural Transmission — Fri, 10 Jun 2011 06:27:04 +0100

Abstract Altered function of kynurenine pathway has emerged recently as one of the factors contributing to the pathogenesis of depression. Neuroprotective kynurenic acid (KYNA) and neurotoxic 3-hydroxykynurenine (3-HK) are two immediate metabolites of l-kynurenine. Here, we aimed to assess the hypothesis that antidepressant drugs that may change brain KYNA/3-HK ratio. In primary astroglial cultures, fluoxetine, citalopram, amitriptyline and imipramine (1–10 μM) increased de novo production of KYNA and diminished 3-HK synthesis (24 and 48, but not 2 h). RT-PCR studies revealed that Kat1, Kat2 and kynurenine-3-monooxygenase (Kmo) gene expressions were not altered after 2 h. At 24 h, the expression of Kat1 and Kat2 genes was enhanced by all studied drugs, ...

Amitriptyline Increases GDNF Production through FGFR [Signal Transduction]

Journal of Biological Chemistry — Thu, 09 Jun 2011 23:00:00 +0100

This study clarifies the type of tyrosine kinase and mechanism of antidepressant-induced GDNF production in C6 glioma cells and normal human astrocytes. The amitriptyline (a tricyclic antidepressant)-induced ERK activation was specifically and completely inhibited by fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors and siRNA for FGFR1 and -2. Treatment with amitriptyline or several different classes of antidepressants, but not non-antidepressants, acutely increased the phosphorylation of FGFRs and FGFR substrate 2α (FRS2α). Amitriptyline-induced CREB phosphorylation and GDNF production were blocked by FGFR-tyrosine kinase inhibitors. Therefore, antidepressants activate the FGFR/FRS2α/ERK/CREB signaling cascade, thus resulting in GDNF production. Furthermore, we attemp...

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AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Preferred Pharmaceuticals, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 09 Jun 2011 05:00:00 +0100

Updated Date: Jun 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 09 Jun 2011 05:00:00 +0100

Updated Date: Jun 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Modulators of Sphingolipid Metabolism Reduce Lung Inflammation.

American Journal of Respiratory Cell and Molecular Biology — Wed, 08 Jun 2011 23:00:00 +0100

Authors: Dechecchi MC, Nicolis E, Mazzi P, Cioffi F, Bezzerri V, Lampronti I, Huang S, Wiszniewski L, Gambari R, Scupoli MT, Berton G, Cabrini G Investigation on novel targets for the treatment of Cystic Fibrosis (CF) lung inflammation is a major priority, considering that no effective therapy is available for this purpose. Consistently with the evidence that the sphingolipid (SL) ceramide regulates airway inflammation and infection in CF mice and patients, SLs have been identified as targets to treat pulmonary disorders, including CF. Because miglustat, an inhibitor of the synthesis of glycosphingolipids, reduces the P.aeruginosa-dependent transcription of IL-8 gene in bronchial cells, we examined the effect of miglustat and amitriptyline, another drug affecting ceramide metabolism, o...

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 03 Jun 2011 05:00:00 +0100

Updated Date: Jun 3, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Platelet aggregation disorder due to amitriptyline.

Farmacia Hospitalaria — Wed, 01 Jun 2011 23:00:00 +0100

Authors: Tacoronte Fontúrbel A, Romero Garrido JA, González Del Valle L, Sánchez Mateo M, Herrero Ambrosio A, Quintana Molina M PMID: 21641257 [PubMed - as supplied by publisher] (Source: Farmacia Hospitalaria)

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AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Jun 2011 05:00:00 +0100

Updated Date: Jun 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Contract Pharmacy Services-PA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 01 Jun 2011 05:00:00 +0100

Updated Date: Jun 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Amitriptyline overdose: Heart arrest and seizures treated with lipid emulsion

Reactions — Thu, 26 May 2011 16:32:02 +0100

(Source: Reactions)

Prolonged Toxicity after Amitriptyline Overdose in a Patient Deficient in CYP2D6 Activity.

Journal of Medical Toxicology — Wed, 25 May 2011 23:00:00 +0100

We present the case of a comatose woman who intentionally overdosed on amitriptyline and displayed rising serum total tricyclic antidepressant concentrations for at least 6 days after admission. Serial immunoassay total tricyclic antidepressant concentrations in our patient showed gradual decline beginning day 7, although the patient did not regain normal mental status until day 12. Genotyping revealed the patient to be homozygous for the CYP2D6*4 allele, the most common explanation of CYP2D6 enzymatic deficiency among Caucasians. Patients taking tricyclic antidepressants who are homozygous for CYP2D6*4 demonstrate >3 times concentration-time curve (AUCs) and prolonged elimination half-lives, especially of secondary amines such as nortriptyline. DISCUSSION: We believe this is the first...

Is Duloxetine More Effective than Amitriptyline for Painful Diabetic Neuropathy?

Current Diabetes Reports — Thu, 19 May 2011 16:12:43 +0100

Content Type Journal ArticlePages 1-3DOI 10.1007/s11892-011-0199-6Authors Andrew J. M. Boulton, Manchester Diabetes Centre, 193 Hathersage Road, Manchester, M13 0JE UK Journal Current Diabetes ReportsOnline ISSN 1539-0829Print ISSN 1534-4827 (Source: Current Diabetes Reports)

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Sleep Disorders and Fibromyalgia

Current Pain and Headache Reports — Thu, 19 May 2011 05:49:57 +0100

Abstract Disordered sleep is such a prominent symptom in fibromyalgia that the American College of Rheumatology included symptoms such as waking unrefreshed, fatigue, tiredness, and insomnia in the 2010 diagnostic criteria for fibromyalgia. Even though sleep recording is not part of the routine evaluation, polysomnography may disclose primary sleep disorders in patients with fibromyalgia, including obstructive sleep apnea and restless leg syndrome. In addition, genetic background and environmental susceptibility link fibromyalgia and further sleep disorders. Among nonpharmacological treatment proposed for sleep disturbance in fibromyalgia, positive results have been obtained with sleep hygiene and cognitive-behavioral therapy. The effect of exercise is contradictory, but o...

Amitriptyline/cyamemazine overdose: Death in an infant and a child: 2 case reports

Reactions — Wed, 18 May 2011 17:09:57 +0100

(Source: Reactions)

Evidence-based guideline: Treatment of painful diabetic neuropathy: Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation

Neurology — Sun, 15 May 2011 23:00:00 +0100

Objective: To develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). Methods: We performed a systematic review of the literature from 1960 to August 2008 and classified the studies according to the American Academy of Neurology classification of evidence scheme for a therapeutic article, and recommendations were linked to the strength of the evidence. The basic question asked was: "What is the efficacy of a given treatment (pharmacologic: anticonvulsants, antidepressants, opioids, others; and nonpharmacologic: electrical stimulation, magnetic field treatment, low-intensity laser treatment, Reiki massage, others) to reduce pain and improve physical function and quality of life (QOL) in patients with PDN?" Res...

IPS Therapeutique Releases New White Paper

Drug Development Technology — Fri, 13 May 2011 14:43:04 +0100

IPS Therapeutique, a contract research organization dedicated to the assessment of cardiovascular efficacy and safety in new chemical entities, has released a new, free-to-download white paper entitled 'Predicting TCA Toxicity Using In Vivo and Ex Vivo Juvenile Safety Models'. The tri-cyclic antidepressant (TCA) amitriptyline is used in the treatment of nocturnal enuresis at doses of 2-7mg/kg in children, despite existing reports of severe cardiac toxicity at doses of 10mg/kg. Cardiac adverse events are frequent and represent the main cause of TCA mortality, via sinus tachycardia and conduc... Read More Related Links: IPS Therapeutique Releases New White Paper Post to: ...

The inhibition characteristics of human placental glutathione S-transferase-π by tricyclic antidepressants: amitriptyline and clomipramine.

Molecular and Cellular Biochemistry — Thu, 12 May 2011 23:00:00 +0100

In this study, the interaction of GST-π with amitriptyline and clomipramine was investigated. The K (m) values for glutathione (GSH) and 1-chloro-2,4-dinitrobenzene (CDNB) were found to be 0.16 ± 0.04 and 3.60 ± 1.67 mM, respectively. The V (m) values were varying according to the fixed substrate; [CDNB] fixed, 53 ± 3 and [GSH] fixed 182 ± 63 U/mg protein. At variable [GSH] and variable [CDNB], the k (cat) values of 7.0 × 10(6) and 1.42 × 10(7) s(-1) and the k (cat)/K (m) values of 4.38 × 10(10) and 3.94 × 10(9 )M(-1 )s(-1) were obtained, respectively. At fixed [CDNB] and variable [GSH], amitriptyline (K (s) = 0.16 ± 0.03 mM; α = 2.08; and K (i) = 1.75 ± 0.37 mM) and clomipramine (K (s) = 0.24 ± 0.05 mM; α = 1.57; and K (i) = 3.90 ±...

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SENTRAVIL PM-25 (Amitriptyline Hydrochloride, Choline) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 12 May 2011 05:00:00 +0100

Updated Date: May 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Interactions of human organic anion transporter 1 (hOAT1) with substances associated with forensic toxicology

Legal Medicine — Tue, 10 May 2011 23:00:00 +0100

In conclusion, the current results suggest that fenitrothion and chlorpyrifosmethyl are transported with pharmacokinetics indicative of hOAT1 involvement in the human kidney. (Source: Legal Medicine)

Amitriptyline, duloxetine equally effective for treating diabetic neuropathy

MedWire News - Diabetes — Tue, 03 May 2011 00:00:00 +0100

The drugs amitriptyline and duloxetine are equally effective for treating painful diabetic neuropathy, show study results. (Source: MedWire News - Diabetes)

Pre-clinical study of 21 approved drugs in the mdx mouse

Neuromuscular Disorders — Sat, 30 Apr 2011 23:00:00 +0100

Abstract: Duchenne muscular dystrophy, a genetic disease caused by the absence of functional dystrophin, remains without adequate treatment. Although great hopes are attached to gene and cell therapies, identification of active small molecules remains a valid option for new treatments.We have studied the effect of 20 approved pharmaceutical compounds on the muscles of dystrophin-deficient mdx5Cv mice. These compounds were selected as the result of a prior screen of 800 approved molecules on a dystrophin mutant of the invertebrate animal model Cænorhabditis elegans. Drugs were administered to the mice through maternal feeding since 2weeks of life and mixed in their food after the 3rd week of life. The effects of the drugs on mice were evaluated both at 6weeks and 16weeks. Each drug was tes...

Effects of Acupuncture in Reducing Attrition and Mortality in HIV-Infected Men with Peripheral Neuropathy

Explore — Sat, 30 Apr 2011 23:00:00 +0100

Conclusions: Acupuncture was clearly effective in reducing attrition and mortality in this sample, especially when health status was taken into account, but results for pain relief were mixed. These results add further evidence that the use of the most sensitive statistics available increases the chance of detecting actual effects due to acupuncture (and other treatments as well). Moreover, these results replicated most of the findings that did not involve the presence of amitriptyline from the initial independent study in this research project. The combined results of therse two studies strongly support the importance of recognizing that interactions involving acupuncture and other treatments, may positively as well as negatively modify main effect results in clinical trials, and thus mus...

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Digest

Progress in Neurology and Psychiatry — Sat, 30 Apr 2011 23:00:00 +0100

AbstractNewsNew DH report on mental health promotionThe Department of Health has published an economic evaluation of the benefits of mental health promotion and preventing mental illness (www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/documents/digitalasset/dh_126386.pdf). Edited by Professor Martin Knapp and colleagues from the London School of Economics and Political Science, with contributions from researchers based largely in the south east of England, the 43‐page report summarises the financial burden and cost effectiveness of interventions to tackle a range of mental health issues in the home, school and workplace. It concludes that many interventions offer outstanding value for money and several are cost‐saving, though the pay‐off period can be several years.Safinamide h...

Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine.

Antimicrobial Agents and Chemotherapy — Sun, 24 Apr 2011 23:00:00 +0100

Authors: Müller F, König J, Glaeser H, Schmidt I, Zolk O, Fromm MF, Maas R The antimalarial drug chloroquine is eliminated to a significant extent by renal tubular secretion. The molecular mechanism of renal chloroquine secretion remains unknown. We hypothesized that organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1), localized in the basolateral and luminal membrane of proximal tubule cells, respectively, are involved in chloroquine transport. The interaction of chloroquine with both transporters was investigated using single-transfected human embryonic kidney 293 (HEK293)-MATE1 cells in uptake experiments and single-transfected Madin-Darby canine kidney II (MDCK)-OCT2 and MDCK-MATE1 cells as well as double-transfected MDCK-OCT2-MATE1 cells grown...

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 21 Apr 2011 05:00:00 +0100

Updated Date: Apr 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis

Neuropsychopharmacology — Tue, 19 Apr 2011 23:00:00 +0100

Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis Neuropsychopharmacology advance online publication, April 20, 2011. doi:10.1038/npp.2011.57 Authors: Jürgen Zschocke, Nicole Zimmermann, Barbara Berning, Vanessa Ganal, Florian Holsboer & Theo Rein Keywords: second messengers; molecular and cellular neurobiology; depression; unipolar/bipolar; autophagosome; lysosome; amitriptyline; citalopram; mitochondria (Source: Neuropsychopharmacology)

Amitriptyline/diphenhydramine overdose: Delirium: case report

Reactions — Sat, 16 Apr 2011 17:06:15 +0100

(Source: Reactions)

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Drug-binding Selectivity in AGP Variants [Molecular Biophysics]

Journal of Biological Chemistry — Thu, 14 Apr 2011 23:00:00 +0100

In this study, we determined the crystal structures of this mutant hAGP alone and complexed with disopyramide (DSP), amitriptyline (AMT), and the nonspecific drug chlorpromazine (CPZ). The crystal structures revealed that the drug-binding pocket on the A variant is located within an eight-stranded β-barrel, similar to that found in the F1*S variant and other lipocalin family proteins. However, the binding region of the A variant is narrower than that of the F1*S variant. In the crystal structures of complexes with DSP and AMT, the two aromatic rings of each drug interact with Phe-49 and Phe-112 at the bottom of the binding pocket. Although the structure of CPZ is similar to those of DSP and AMT, its fused aromatic ring system, which is extended in length by the addition of a chlorine atom...

Amiodarone/amitriptyline interaction: First report of an interaction, leading to extrapyramidal symptoms in an elderly patient: case report

Reactions — Tue, 12 Apr 2011 16:15:37 +0100

(Source: Reactions)

Prevalence and risk factors for inappropriate drug use among older people: results from an Indian public outpatient setting

NeLM - Care of Older People — Mon, 11 Apr 2011 23:00:00 +0100

Source: Journal of Pharmaceutical Health Services Research Area: Evidence > Medicines Management > References Objectives: To determine the prevalence and risk factors associated with prescribing of inappropriate drugs using Modified Beers' criteria 2003, in older patients consulting medical specialists at a Geriatric Outpatient Clinic in India. Methods: This was a prospective interventional study with 1081 participants aged 60 years or over, of both sexes. Key Findings: The average number of medications was 6.32 +/- 0.08. Only 117 patients were prescribed at least one inappropriate drug (10.8%). Out of these, 112 received only one inappropriate drug while 5 patients received two. Therefore, there were 122 cases of inappropriate drug use (IDU; 11.28%). The ...

Amitriptyline induces coenzyme Q deficiency and oxidative damage in mouse lung and liver.

Toxicology Letters — Fri, 08 Apr 2011 23:00:00 +0100

Authors: Bautista-Ferrufino MR, Cordero MD, Sánchez-Alcázar JA, Illanes M, Fernández-Rodríguez A, Navas P, de Miguel M Amitriptyline is a tricyclic antidepressant commonly prescribed for the treatment of several neuropathic and inflammatory illnesses. We have already reported that amitriptyline has cytotoxic effect in human cell cultures, increasing oxidative stress, and decreasing growth rate and mitochondrial activity. Coenzyme Q (CoQ), a component of the respiratory chain and a potent antioxidant, has been proposed as a mitochondrial dysfunction marker. In the present work we evaluated lipid peroxidation, a consequence of oxidative stress, and CoQ level in liver, lung, kidney, brain, heart, skeletal muscle, and serum of mice treated with amitriptyline for two weeks. Lipid peroxi...

Effect of glibenclamide on antinociceptive effects of antidepressants of different classes

Clinics — Fri, 08 Apr 2011 17:59:05 +0100

CONCLUSION: Therefore, it seems that adenosine triphosphate-dependent potassium channels have a major role in the analgesic activity of amitriptyline and fluvoxamine. (Source: Clinics)

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Amitriptyline overdose: Supraventricular tachycardia, seizures, hypotension and unconsciousness in an infant: case report

Reactions — Mon, 04 Apr 2011 16:58:12 +0100

(Source: Reactions)

Topical Amitriptyline in Post-Traumatic Neuropathic Pain

Journal of Pain and Symptom Management — Thu, 31 Mar 2011 23:00:00 +0100

Neuropathic pain due to traumatic injury often has a poor prognosis. Trials evaluating pharmacologic treatment of post-traumatic neuropathic pain are extremely rare. Therefore, extrapolation of results based on trials in nontraumatic neuropathic pain is common practice. Amitriptyline is generally seen as a first-choice treatment for neuropathic pain. However, adverse effects can limit patient compliance and thus the effectiveness of oral medication. Topically applied amitriptyline can reduce systemic adverse effects because of low systemic concentration of the active compound, a gradual delivery, and a possible local effect. (Source: Journal of Pain and Symptom Management)

Evidence-based Guideline: Treatment of Painful Diabetic Neuropathy: Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation

PM and R — Thu, 31 Mar 2011 23:00:00 +0100

21. Phantom Pain

Pain Practice — Tue, 29 Mar 2011 23:00:00 +0100

Abstract: Phantom pain is pain caused by elimination or interruption of sensory nerve impulses by destroying or injuring the sensory nerve fibers after amputation or deafferentation. The reported incidence of phantom limb pain after trauma, injury or peripheral vascular diseases is 60% to 80%. Over half the patients with phantom pain have stump pain as well. Phantom pain can also occur in other parts of the body; it has been described after mastectomies and enucleation of the eye.Most patients with phantom pain have intermittent pain, with intervals that range from 1 day to several weeks. Even intervals of over a year have been reported. The pain often presents itself in the form of attacks that vary in duration from a few seconds to minutes or hours. In most cases, the pain is experi...

Analysis of amitriptyline overdose in emergency medicine

Emergency Medicine Journal — Thu, 24 Mar 2011 00:00:00 +0100

Conclusion Most of the patients were young single women. Altered mental state and tachycardia were the commonest symptoms. The initial symptoms of amytriptyline overdose patients may be life threatening, but effective supportive treatments were helpful. There was high correlation between ADORA criteria and the dose ingested. (Source: Emergency Medicine Journal)

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[Amitriptyline-induced cardiac arrest : Treatment with fat emulsion.]

Der Anaesthesist — Thu, 24 Mar 2011 00:00:00 +0100

Authors: Huge V, Baschnegger H, Moehnle P, Peraud A, Briegel J A case of successful resuscitation of a patient with severe amitriptyline intoxication is reported. The measured amitriptyline serum levels far exceeded those assumed to be lethal according to the literature. Resuscitation was successful with the administration of intravenous fat emulsion and the patient recovered without any neurological sequelae. PMID: 21437755 [PubMed - as supplied by publisher] (Source: Der Anaesthesist)

Amitriptyline/antiemetics/antipsychotics: Various toxicities: 12 case reports

Reactions — Tue, 22 Mar 2011 17:01:08 +0100

(Source: Reactions)

Both Amitriptyline and Duloxetine Ease Diabetic Neuropathy

Medscape Diabetes Headlines — Thu, 10 Mar 2011 22:24:34 +0100

Pain associated with diabetic neuropathy is improved to a similar degree with daily amitriptyline or duloxetine, according to the results of a cross-over trial conducted in India. Reuters Health Information (Source: Medscape Diabetes Headlines)

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Southeast Medical Solutions RX LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 10 Mar 2011 05:00:00 +0100

Updated Date: Mar 10, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Prevalence and outcomes of use of potentially inappropriate medicines in older people: cohort study stratified by residence in nursing home or in the community

Quality and Safety in Health Care — Wed, 09 Mar 2011 00:00:00 +0100

Conclusions The authors question the validity of the full list of PIMs as an indicator of safety of medicines in older people because one-third of the population is exposed with little practice variation and no significant impact on mortality. Future studies should focus on management of a shorter list of genuinely high-risk medicines. (Source: Quality and Safety in Health Care)

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Evidence‐based guideline: Treatment of painful diabetic neuropathy—report of the american association of neuromuscular and electrodiagnostic medicine, the american academy of neurology, and the american academy of physical medicine & rehabilitation

Muscle and Nerve — Wed, 09 Mar 2011 00:00:00 +0100

The objective of this report was to develop a scientifically sound and clinically relevant evidence‐based guideline for the treatment of painful diabetic neuropathy (PDN). The basic question that was asked was: “What is the efficacy of a given treatment (pharmacological: anticonvulsants, antidepressants, opioids, others; non‐pharmacological: electrical stimulation, magnetic field treatment, low‐intensity laser treatment, Reiki massage, others) to reduce pain and improve physical function and quality of life (QOL) in patients with PDN?” A systematic review of literature from 1960 to August 2008 was performed, and studies were classified according to the American Academy of Neurology classification of evidence scheme for a therapeutic article. Recommendations were linked to the str...

Amitriptyline/ziprasidone: QT interval prolongation and heart block: case report

Reactions — Sun, 06 Mar 2011 17:02:10 +0100

(Source: Reactions)

AMITRIPTYLINE HYDROCHLORIDEtablet, Film Coated [Lake Erie Medical DBA Quality Care Products LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 03 Mar 2011 05:00:00 +0100

Updated Date: Mar 3, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Chronic coccydynia in adolescents. A series of 53 patients.

European Journal of Physical and Rehabilitation Medicine — Wed, 02 Mar 2011 00:00:00 +0100

CONCLUSION: Coccydynia in adolescents differs from coccydynia in adults. A MRI scan is helpful and should be obligatory for diagnosis. Prognosis is relatively good. Clinical rehabilitation impact. Our results should help clinicians manage this rare and debilitating condition. PMID: 21364508 [PubMed - as supplied by publisher] (Source: European Journal of Physical and Rehabilitation Medicine)

Small crossover study finds amitriptyline and duloxetine similarly effective in painful diabetic neuropathy

NeLM - News — Tue, 01 Mar 2011 00:00:00 +0100

This study was designed to directly compare duloxetine with amitriptyline, as the authors failed to find any such head-to-head study from an extensive search of the literature. The 14-week study included 58 adults with type 2 diabetes who had PDN for at least one month, with a pain score of >50% on visual analogue ... (Source: NeLM - News)

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Evidence‐based guideline: Treatment of painful diabetic neuropathy

Muscle and Nerve — Tue, 01 Mar 2011 00:00:00 +0100

The objective of this report was to develop a scientifically sound and clinically relevant evidence based guideline for the treatment of painful diabetic neuropathy (PDN). The basic question that was asked was “What is the efficacy of a given treatment (pharmacological: anticonvulsants, antidepressants, opioids, others; and non‐pharmacological: electrical stimulation, magnetic field treatment, low‐intensity laser treatment, Reiki massage, others) to reduce pain and improve physical function and quality of life (QOL) in patients with PDN?”A systematic review of literature from 1960 to August 2008 was performed and studies were classified according to the American Academy of Neurology classification of evidence scheme for a therapeutic article. Recommendations were linked to the stre...

Health Outcomes and Costs among Employees with Fibromyalgia Treated with Pregabalin vs. Standard of Care

Pain Practice — Tue, 01 Mar 2011 00:00:00 +0100

Conclusion: Despite several comorbidity and drug use differences, most employee benefit outcomes and adherence did not differ between the cohorts. (Source: Pain Practice)

Amitriptyline/lorazepam: Delirium in elderly patients: 2 case reports

Reactions — Sun, 27 Feb 2011 18:11:29 +0100

(Source: Reactions)

A Comparative Trial to Evaluate Amitriptyline and Duloxetine in Painful Diabetic Neuropathy: A randomized, double-blind, cross-over clinical trial.

Diabetes Care — Fri, 25 Feb 2011 00:00:00 +0100

CONCLUSIONS Both duloxetine and amitriptyline demonstrated similar efficacy in PDN. A large, multicentric clinical trial in other populations could possibly demonstrate the superiority of either drug. PMID: 21355098 [PubMed - as supplied by publisher] (Source: Diabetes Care)