MedWorm: Benztropine

BENZTROPINE MESYLATEtablet [Cardinal Health]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 14 Oct 2011 05:00:00 +0100

Updated Date: Oct 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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BENZTROPINE MESYLATEtablet [Dispensing Solutions, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 04 Oct 2011 05:00:00 +0100

Updated Date: Oct 4, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 22 Sep 2011 05:00:00 +0100

Updated Date: Sep 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [NCS HealthCare Of KY, Inc Dba Vangard Labs]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 29 Aug 2011 05:00:00 +0100

Updated Date: Aug 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Immediate-Release Oxybutynin for the Treatment of Clozapine-Induced Sialorrhea (September).

The Annals of Pharmacotherapy — Wed, 17 Aug 2011 23:00:00 +0100

CONCLUSIONS: To our knowledge, this is the first report of immediate-release oxybutynin successfully reducing clozapine-induced sialorrhea. If oxybutynin is considered for this indication, use of the immediate-release formulation seems prudent. Additional data, including randomized controlled trials, are needed to confirm whether immediate-release oxybutynin has a significant role in the management of this stigmatizing adverse effect. PMID: 21852588 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

BENZTROPINE MESYLATEtablet [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 05 Aug 2011 05:00:00 +0100

Updated Date: Aug 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 26 Jul 2011 05:00:00 +0100

Updated Date: Jul 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [Corepharma LLC.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 11 Jul 2011 05:00:00 +0100

Updated Date: Jul 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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BENZTROPINE MESYLATE (Benztropine Mesylate) Tablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 05 Jul 2011 05:00:00 +0100

Updated Date: Jul 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [American Health Packaging]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 20 Jun 2011 05:00:00 +0100

Updated Date: Jun 20, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATE (Benztropine Mesylate) Tablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 15 Jun 2011 05:00:00 +0100

Updated Date: Jun 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 15 Jun 2011 05:00:00 +0100

Updated Date: Jun 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Combination Loxapine and Aripiprazole for Refractory Hallucinations in Schizophrenia (July/August).

The Annals of Pharmacotherapy — Mon, 13 Jun 2011 23:00:00 +0100

CONCLUSIONS The combination of aripiprazole and high-dose loxapine should be considered in patients with schizophrenia who develop treatment-refractory hallucinations, particularly those who are unwilling to accept treatment with either depot antipsychotics or clozapine. PMID: 21672885 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

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BENZTROPINE MESYLATEtablet [Qualitest Pharmaceuticals]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 07 Jun 2011 05:00:00 +0100

Updated Date: Jun 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 19 May 2011 05:00:00 +0100

Updated Date: May 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEinjection, Solution [American Regent, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 11 May 2011 05:00:00 +0100

Updated Date: May 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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BENZTROPINE MESYLATEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 10 May 2011 05:00:00 +0100

Updated Date: May 10, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Improvement in Drug-Induced Parkinsonism With Electroconvulsive Therapy.

The American Journal of Geriatric Pharmacotherapy — Mon, 09 May 2011 23:00:00 +0100

CONCLUSIONS: This was a case of probable drug-induced parkinsonism in an elderly woman who had improvement of her depression and parkinsonism after receiving ECT. PMID: 21565562 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Pharmacotherapy)

BENZTROPINE MESYLATEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 02 May 2011 05:00:00 +0100

Updated Date: May 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [Cardinal Health]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 28 Apr 2011 05:00:00 +0100

Updated Date: Apr 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 07 Apr 2011 05:00:00 +0100

Updated Date: Apr 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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BENZTROPINE MESYLATEtablet [Rebel Distributors Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 07 Apr 2011 05:00:00 +0100

Updated Date: Apr 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

COGENTIN (Benztropine Mesylate) Injection, Solution [Lundbeck Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 05 Apr 2011 05:00:00 +0100

Updated Date: Apr 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pharmacokinetics of the Long-Acting, First-Generation Antipsychotic Fluphenazine

Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy — Tue, 29 Mar 2011 23:00:00 +0100

We describe a 55-year-old schizophrenic man with a severe movement disorder whose symptoms were mistaken for lithium toxicity. Further examination revealed that his fluphenazine plasma level was still detected 4 months after his last dose of fluphenazine decanoate had been administered. The incorrect diagnosis of lithium toxicity resulted in delayed treatment of his severe extrapyramidal symptoms. Administration of a routine dosage of benztropine titrated to 4 mg/day resolved his drug-induced movement disorder within 72 hours. This case report demonstrates the persistent need for practitioners' awareness of the complex pharmacokinetic properties of long-term fluphenazine decanoate treatment, resulting in prolonged absorption, and the continued importance of both recognizing adverse events ...

Utilization of anti‐Parkinson drugs in Australia: 1995–2009

Pharmacoepidemiology and Drug Safety — Tue, 01 Feb 2011 00:00:00 +0100

ConclusionsThe amount of levodopa dispensed has slowly increased with levodopa + benserazide increasing faster than levodopa + carbidopa. Use of cabergoline fell when pramipexole became available and the risk of ergot‐related serosal adverse effects was more widely appreciated. Use of centrally acting anti‐cholinergics decreased over a period of time when use of atypical anti‐psychotic agents increased. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

BENZTROPINE MESYLATEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 22 Dec 2010 05:00:00 +0100

Updated Date: Dec 22, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Paralytic ileus requiring hospitalization secondary to high-dose antipsychotic polypharmacy and benztropine

General Hospital Psychiatry — Mon, 06 Dec 2010 00:00:00 +0100

We present a patient who developed a paralytic ileus requiring extended hospitalization. Providers should minimize antipsychotic and concurrent anticholinergic medications, consider prophylactic bowel regimens and monitor for constipation. (Source: General Hospital Psychiatry)

BENZTROPINE MESYLATEtablet [Goldline Laboratories, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 24 Nov 2010 05:00:00 +0100

Updated Date: Nov 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [Corepharma LLC.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 16 Nov 2010 05:00:00 +0100

Updated Date: Nov 16, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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BENZTROPINE MESYLATEtablet [State Of Florida DOH Central Pharmacy]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 05 Aug 2010 05:00:00 +0100

Updated Date: Aug 5, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [Contract Pharmacy Services-PA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 29 Jun 2010 05:00:00 +0100

Updated Date: Jun 29, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

COGENTIN (Benztropine Mesylate) Injection, Solution [Lundbeck Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 14 May 2010 05:00:00 +0100

Updated Date: May 14, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [NCS HealthCare Of KY, Inc Dba Vangard Labs]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 04 May 2010 05:00:00 +0100

Updated Date: May 4, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The high affinity dopamine uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization

European Neuropsychopharmacology — Wed, 21 Apr 2010 23:00:00 +0100

We examined in mice the behavioural effects of (N-(n-butyl)-3α-[bis(4′-fluorophenyl)methoxy]-tropane) (JHW 007), a benztropine (BZT) analogue that blocks dopamine uptake, and assessed its potential to influence the actions of cocaine in clinically-relevant models of cocaine addiction. In the conditioned place preference (CPP) paradigm, JHW 007 exposure did not produce place conditioning within an ample dose range but effectively blocked the CPP induced by cocaine administration. Similarly, in the CPP apparatus JHW 007 treatment failed to stimulate locomotor activity at any dose but dose-dependently suppressed the hyperactivity evoked by cocaine treatment. In locomotor sensitization assays performed in the open field, JHW 007 did not produce sensitized locomotor behaviour when given alon...

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BENZTROPINE MESYLATEtablet [Goldline Laboratories, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 31 Mar 2010 05:00:00 +0100

Updated Date: Mar 31, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [Pliva Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 29 Mar 2010 05:00:00 +0100

Updated Date: Mar 29, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [State Of Florida DOH Central Pharmacy]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 26 Mar 2010 05:00:00 +0100

Updated Date: Mar 26, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [Corepharma LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 19 Mar 2010 05:00:00 +0100

Updated Date: Mar 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Benztropine

About.com Bipolar Disorder — Fri, 12 Mar 2010 00:00:00 +0100

is a drug used to treat symptoms of Parkinson's disease and secondary parkinsonism. More... (Source: About.com Bipolar Disorder)

BENZTROPINE MESYLATEtablet [Rising Pharmaceuticals Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 24 Feb 2010 05:00:00 +0100

Updated Date: Feb 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [American Health Packaging]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 19 Jan 2010 05:00:00 +0100

Updated Date: Jan 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [Pliva Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 02 Dec 2009 05:00:00 +0100

Updated Date: Dec 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEtablet [UDL Laboratories, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 19 Nov 2009 05:00:00 +0100

Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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BENZTROPINE MESYLATEinjection [West-Ward Pharmaceutical Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Sep 2009 05:00:00 +0100

Updated Date: Sep 22, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat

Psychopharmacology — Tue, 15 Sep 2009 22:08:20 +0100

Conclusions These findings demonstrate essential psychopharmacological differences between AHN-1055 and cocaine and highlight important properties of the analog as a possible pharmacotherapy in cocaine addiction. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1653-xAuthors Antonio Ferragud, University of Valencia-General Foundation & Red de Trastornos Adictivos (RETICS) Biopsychology and Comparative Neuroscience Group, Cavanilles Institute (ICBiBE) Polígono de la Coma s/n, Paterna 46980 Valencia SpainClara Velázquez-Sánchez, University of Valencia-General Foundation & Red de Trastornos Adictivos (RETICS) Biopsychology and Comparative Neuroscience Group, Cavanilles Institute (ICBiBE) Polígono de la Coma s/n, Paterna 46980 Valencia ...

What Are The Options for Treating Excessive Salivation?

PediatricEducation.org — Mon, 07 Sep 2009 00:01:02 +0100

Discussion Drooling, excessive salivation, hypersalivation, or sialorrhea can be a big problem for children. It can cause wet clothing necessitating bibs or multiple changes of clothing. It can cause dermatitis of the face, neck and chest, with possible skin breakdown and/or possible secondary infection. Sialorrhea can also potentiate the spread of common infections to others though direct or indirect contact with the saliva. It can also cause impaired social interaction as noted above. Therefore it is a problem that should be taken seriously and treated as necessary. Sialorrhea is generally considered abnormal if it occurs during the day after the age of 3-4 years. Most people affected have some other neurological problem including cerebral palsy or in adult populations, patients with Pa...

BENZTROPINE MESYLATEinjection, Solution [Hikma Farmaceutica]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 04 Sep 2009 05:00:00 +0100

Updated Date: Sep 4, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BENZTROPINE MESYLATEinjection [Nexus Pharmaceuticals Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 13 Aug 2009 05:00:00 +0100

Updated Date: Aug 13, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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BENZTROPINE MESYLATEtablet [Actavis Totowa LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 23 Jun 2009 05:00:00 +0100

Updated Date: Jun 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cogentin Side Effects

About.com Bipolar Disorder — Sat, 07 Mar 2009 05:00:00 +0100

Catalogue of side effects for the medication Benztropine - brand name Cogentin - which is used to treat some of the side effects of certain antipsychotic medications. It is classed as an antiparkinsonian drug. (Source: About.com Bipolar Disorder)

[Articles] Double-Blind Comparison of First- and Second-Generation Antipsychotics in Early-Onset Schizophrenia and Schizo-affective Disorder: Findings From the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) Study

Am J Psychiatry — Mon, 03 Nov 2008 05:00:00 +0100

CONCLUSIONS: Risperidone and olanzapine did not demonstrate superior efficacy over molindone for treating early-onset schizophrenia and schizoaffective disorder. Adverse effects were frequent but differed among medications. The results question the nearly exclusive use of second-generation antipsychotics to treat early-onset schizophrenia and schizoaffective disorder. The safety findings related to weight gain and metabolic problems raise important public health concerns, given the widespread use of second-generation antipsychotics in youth for nonpsychotic disorders. (Source: Am J Psychiatry)

Double-Blind Comparison of First- and Second-Generation Antipsychotics in Early-Onset Schizophrenia and Schizo-affective Disorder: Findings From the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) Study.

The American Journal of Psychiatry — Mon, 15 Sep 2008 04:00:00 +0100

Conclusions Risperidone and olanzapine did not demonstrate superior efficacy over molindone for treating early-onset schizophrenia and schizoaffective disorder. Adverse effects were frequent but differed among medications. The results question the nearly exclusive use of second-generation antipsychotics to treat early-onset schizophrenia and schizoaffective disorder. The safety findings related to weight gain and metabolic problems raise important public health concerns, given the widespread use of second-generation antipsychotics in youth for nonpsychotic disorders. PMID: 18794207 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)

Interaction of cocaine-, benztropine-, and gbr12909-like compounds with wildtype and mutant human dopamine transporters: molecular features that differentially determine antagonist binding properties.

Journal of Neurochemistry — Thu, 11 Sep 2008 04:00:00 +0100

This study furthers the concept of using DAT mutants to differentiate cocaine-like inhibitors from atypical inhibitors in vitro. Further studies of the molecular features that define inhibitor-transporter interaction could lead to the development of DAT inhibitors with differential clinical utility. PMID: 18786172 [PubMed - as supplied by publisher] (Source: Journal of Neurochemistry)

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Benztropine Mesylate(Benztropine Mesylate) Tablet [UPSHER-SMITH LABORATORIES, INC.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 19 Mar 2008 05:00:00 +0100

Updated Date: Mar 19, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Benztropine-induced Esotropia and Mydriasis.

Journal of Neuro-Ophthalmology — Tue, 04 Dec 2007 01:24:48 +0100

Page: 312DOI: 10.1097/WNO.0b013e31815bfb04Authors: Oh, Sun-Young MD 1; Shin, Byoung-Soo MD 1; Lee, Yeon-Hee MD 2; Lee, Ae Young MD 3; Kim, Ji Soo MD 4 (Source: Journal of Neuro-Ophthalmology)

Azacitidine-Associated Hyperthermia and Interstitial Pneumonitis in a Patient with Myelodysplastic Syndrome

Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy — Tue, 27 Nov 2007 05:00:00 +0100

We describe a 55-year-old woman who was treated with azacitidine for myelodysplastic syndrome and experienced hyperthermia that was not attributable to other causes. The patient's treatment course was further complicated by interstitial pneumonitis and hypoxic respiratory failure that ultimately led to acute respiratory distress syndrome. Hyperthermia develops when discord occurs between metabolic heat production and heat dissipation. The process of temperature regulation can be altered by drugs such as succinylcholine, phenothiazines, monoamine oxidase inhibitors, atropine, benztropine, antihistamines, cocaine, Ecstasy, amphetamines, and haloperidol. The hyperthermia in this patient was refractory to antipyretic therapy and was not due to other drug-induced hyperthermic syndromes. She eve...

Fatal exertional heat stroke in a patient receiving zuclopenthixol, quetiapine and benztropine.

Can J Clin Pharmacol — Thu, 22 Nov 2007 01:27:16 +0100

Authors: Kao RL, Kelly LM Objective To report a case of fatal exertional heat stroke associated with the use of zuclopenthixol, quetiapine and benztropine. Case Summary A 36-year-old male with a history of schizophrenia and bipolar disease was working as a roofer during the third day of a heat wave. His medications included zuclopenthixol, quetiapine, benztropine, carbamazepine and levothyroxine. He developed loss of consciousness late in the day and presented to hospital with a Glasgow Coma Scale 3 and a rectal temperature of 42.20C. He progressed to severe multiple organ dysfunction and asystole, and expired the following morning. Neuroleptic and anticholinergic agents have long been associated with heat alteration, but there are few reports involving the newer antipsychotic agents. ...

Role of calcium-independent phospholipase A2 in cortex striatum thalamus cortex circuitry–enzyme inhibition causes vacuous chewing movements in rats

Psychopharmacology — Tue, 04 Sep 2007 14:48:22 +0100

Conclusions These results suggest an important role for iPLA2 in the cortex–striatum–thalamus–cortex circuitry. It is postulated that VCM induced by iPLA2 inhibition may be a model of human parkinsonian tremor. Content TypeJournal Article JournalPsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology)

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Benztropine Mesylate(BENZTROPINE MESYLATE) Tablet [COREPHARMA LLC.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 29 Jun 2007 05:00:00 +0100

Updated Date: Jun 29, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Benztropine pretreatment does not affect responses to acute cocaine administration in human volunteers

Human Psychopharmacology: Clinical and Experimental — Sat, 04 Nov 2006 05:00:00 +0100

This study of one of the tropane-ring analogs that is approved for human use suggests this compound does not alter cocaine-induced effects, but just as importantly, does not produce any adverse behavioral or physiological effects. The exact therapeutic application of benztropine as a possible adjunct treatment for cocaine abuse in humans require further exploration. Copyright © 2006 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)

Review: Dystonia

NeLM Headline News — Thu, 24 Aug 2006 00:00:00 +0100

This article discusses the following: • Clinical Features • Classification (Primary dystonia, primary generalised torsion dystonia, primary focal dystonia, secondary dystonia, heredodegenerative disorders, drug-induced dystonia, acquired structural lesions, dystonia-plus syndromes, paroxysmal dystonia). • Pathophysiology • Evaluation • Treatment (pharmacotherapy, botulinum toxin, surgery, physical therapies) The article notes that acute drug-induced dystonia can be caused by levodopa, dopamine agonists, antipsychotic drugs, anticonvulsant agents, SSRIs, and rarely by other miscellaneous drugs. In addition, persistent tardive dystonia may occur after prolonged use of dopamine-receptor–blocking antipsychotic drugs and metoclopramide. It may also occur as a result of the toxi...

Gain of function mutants reveal sites important for the interaction of the atypical inhibitors benztropine and bupropion with monoamine transporters

Journal of Neurochemistry — Mon, 24 Jul 2006 22:15:32 +0100

Journal of Neurochemistry Volume 0, Issue 0, Page ???-???. (Source: Journal of Neurochemistry)

Levomepromazine versus chlorpromazine in treatment-resistant schizophrenia: a double-blind randomized trial.

J Psychiatry Neurosc... — Fri, 14 Jul 2006 06:00:00 +0100

CONCLUSION: LMP and CPZ may be useful in the management of TRS. A modest advantage of LMP compared with CPZ was seen in longitudinal analysis. High doses of neuroleptics may contribute to TRS; reduction of neuroleptics to modest or moderate doses should be considered before categorizing a patient as treatment resistant. PMID: 16862245 [PubMed - as supplied by publisher] (Source: J Psychiatry Neurosc...)

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