MedWorm: Bisoprolol

BCG/bisoprolol/rifampicin: BCG-induced tuberculosis, and bisoprolol/rifampicin interaction leading to hypertension and arrhythmia, in an elderly patient: case report

Reactions — Fri, 13 Jan 2012 23:22:43 +0100

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BISOPROLOL FUMARATEtablet, Film Coated [Aurobindo Pharma Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 12 Jan 2012 05:00:00 +0100

Updated Date: Jan 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Sensitive determination of prohibited drugs in dried blood spots (DBS) for doping controls by means of a benchtop quadrupole/Orbitrap mass spectrometer.

Analytical and Bioanalytical Chemistry — Tue, 10 Jan 2012 05:00:00 +0100

Authors: Thomas A, Geyer H, Schänzer W, Crone C, Kellmann M, Moehring T, Thevis M Abstract In the present study, a new type of mass spectrometer combining a quadrupole mass filter, a higher collision dissociation (HCD) cell and an Orbitrap detector, was evaluated for the analysis of dried blood spots (DBS) in doping controls. DBS analysis is characterized by the necessity to detect prohibited compounds in sub-nanogram-per-milliliter levels with high identification capacity. After extraction of DBS with an organic solvent and liquid chromatographic separation (using a regular C18-RP-analytical UHPLC-column) of target analytes, mass spectrometry is performed with a high-resolution full scan in positive and negative mode by means of electrospray ionisation. Single-product ion mass sp...

Cement-augmented dorsal instrumentation of the spine as a safe adjunct to the multimodal management of metastatic pheochromocytoma: A case report.

Patient Safety in Surgery — Thu, 05 Jan 2012 05:00:00 +0100

Authors: Rittirsch D, Battegay E, Zimmerli LU, Baulig W, Spahn DR, Ossendorf C, Wanner GA, Simmen HP, Werner CM Abstract ABSTRACT: Malignant pheochromocytoma is a neuroendocrine tumor that originates from chromaffin tissue. Although osseous metastases are common, metastatic dissemination to the spine rarely occurs. Five years after primary diagnosis of extra-adrenal, abdominal pheochromocytoma and laparoscopic extirpation, a 53-year old patient presented with recurrence of pheochromocytoma involving the spine, the pelvis, both proximal femora and the right humerus. Magnetic resonance imaging and computed tomography revealed osteolytic lesions of numerous vertebrae (T1, T5, T10, and T12). In the case of T10, total destruction of the vertebral body with involvement of the rear edge r...

BISOPROLOL FUMARATEtablet, Coated [American Health Packaging]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 20 Dec 2011 05:00:00 +0100

Updated Date: Dec 20, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 15 Dec 2011 05:00:00 +0100

Updated Date: Dec 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Eon Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 13 Dec 2011 05:00:00 +0100

Updated Date: Dec 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATEtablet, Coated [Eon Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 12 Dec 2011 05:00:00 +0100

Updated Date: Dec 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet [Unichem Pharmaceuticals (USA), Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 09 Dec 2011 05:00:00 +0100

Updated Date: Dec 9, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The influence of antihypertensive treatment on arterial stiffness and selected matrix metalloproteinases plasma activity

Artery Research — Thu, 01 Dec 2011 05:00:00 +0100

The aim of the study was to compare the effects of 5 selected drugs on arterial stiffness and matrix metalloproteinases (MMPs) plasma activity in patients with essential arterial hypertension (HT).Material and methods: 95 pts. with HT stage 1 and 2, (N=19 in each treatment group) were treated for 6 months by: quinapril 20-40 mg/d (group-1), amlodipine 5-10mg/d (group-2), hydrochlorothiazide 12,5-25mg/d (group-3), losartan 50-100 mg/d (group 4), bisoprolol 5-10 mg/d (group-5). Before and then after 1,3 and 6 months of treatment office blood pressure (BP) was measured using Omron M5-I device. Carotid femoral pulse wave velocity (PWV) was measured using 3 devices Complior®, Sphygmocor® and ArteriographTM.. Plasma concentration of (MMPs): MMP1, MMP2, MMP3, MMP9 and MMPs tissue inhibitor (TIM...

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (Bisoprolol Fumarate And Hydrochlorothiazide) Tablet, Coated [Med-Health Pharma, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 17 Nov 2011 05:00:00 +0100

Updated Date: Nov 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Differential Effect of β‐Blockers for Heart Rate Control in Coronary Artery Disease

Clinical Cardiology — Mon, 14 Nov 2011 05:00:00 +0100

Conclusions:RHR is poorly controlled in CAD patients, and although BBs are the most efficient therapy, in daily clinical practice RHR <70 bpm is only independently associated with atenolol, bisoprolol, or metoprolol. © 2011 Wiley Periodicals, Inc.The TRECE registry has an unrestricted grant from Servier Laboratories, Spain. The authors have no other funding, financial relationships, or conflicts of interest to disclose. (Source: Clinical Cardiology)

Oral presentation

Pacing and Clinical Electrophysiology : PACE — Tue, 01 Nov 2011 04:00:00 +0100

Conclusion: i.v. niferidile in doses up to 30 mkg/kg seems to be very effective (up to 88%) and safe for sinus rhythm restoration in patients with persistent AF and AFL.O002ELECTROPHYSIOLOGIC AND ANTIARRHYTHMIC EFFECTS OF NEW CLASS III AGENT NIFERIDILE IN PATIENTS WITH PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIASMironov NYu; Golitsyn SP; Sokolov SF; Yuricheva YuA; Maikov EB; Shlevkov NB; Rosetstraukh LV; Chazov EI  Russian cardiology research complexBackground: According to preclinical studies Niferidile (Nf) is a novel potassium channel blocker that inhibits transient outward and delayed rectifier currents and increases effective refractory periods (ERP) more in atria, less in ventricles. High affinity of Nf to atrial myocardium predispose to high efficacy in patients with supraventricular ...

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 20 Oct 2011 05:00:00 +0100

Updated Date: Oct 20, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATEtablet [Unichem Pharmaceuticals (USA), Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 14 Oct 2011 05:00:00 +0100

Updated Date: Oct 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Film Coated [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 05 Oct 2011 05:00:00 +0100

Updated Date: Oct 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Bisoprolol/diltiazem/propranolol: Bradycardia and hypotension in an elderly patient: case report

Reactions — Mon, 03 Oct 2011 06:00:13 +0100

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BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Med-Health Pharma, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 27 Sep 2011 05:00:00 +0100

Updated Date: Sep 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Eon Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 21 Sep 2011 05:00:00 +0100

Updated Date: Sep 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATEtablet, Coated [Eon Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 21 Sep 2011 05:00:00 +0100

Updated Date: Sep 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Bisoprolol/olanzapine/paracetamol overdose: Various toxicities, leading to refeeding syndrome in a cachectic patient: case report

Reactions — Sun, 18 Sep 2011 23:35:47 +0100

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BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Med-Health Pharma, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 25 Aug 2011 05:00:00 +0100

Updated Date: Aug 25, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Aptamer Neutralization of Beta1-Adrenoceptor Autoantibodies Isolated From Patients With Cardiomyopathies.

Circulation Research — Wed, 24 Aug 2011 23:00:00 +0100

Conclusions:A specific aptamer that can neutralize cardiomyopathy associated human beta1-AABs in vitro has been identified and characterized, providing a framework for future in vivo testing of this treatment option in animal experiments. PMID: 21868696 [PubMed - as supplied by publisher] (Source: Circulation Research)

BISOPROLOL FUMARATEtablet, Coated [Eon Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 17 Aug 2011 05:00:00 +0100

Updated Date: Aug 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Ziac (Bisoprolol and Hydrochlorothiazide) - updated on RxList

RxList - New and Updated Drug Monographs — Tue, 16 Aug 2011 07:00:00 +0100

Ziac (Bisoprolol and Hydrochlorothiazide) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

Efficacy of Ivabradine in Combination with Beta-Blocker Versus Uptitration of Beta-Blocker in Patients with Stable Angina

Cardiovascular Drugs and Therapy — Wed, 10 Aug 2011 15:40:02 +0100

Conclusions These results suggest that combining ivabradine with low dose bisoprolol in stable angina patients produces additional antianginal and anti-ischemic benefits and improves chronotropic reserve. Content Type Journal ArticlePages 1-7DOI 10.1007/s10557-011-6327-3Authors E. Amosova, National Medical University, Kiev, UkraineE. Andrejev, National Medical University, Kiev, UkraineI. Zaderey, National Medical University, Kiev, UkraineU. Rudenko, National Medical University, Kiev, UkraineC. Ceconi, Department of Cardiology, University of Ferrara, Corso Giovecca 203, 44121 Ferrara, ItalyR. Ferrari, Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy Journal Cardiovascular Drugs an...

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Influence of Order and Type of Drug (Bisoprolol Vs. Enalapril) on Outcome and Adverse Events in Patients With Chronic Heart FailureInfluence of Order and Type of Drug (Bisoprolol Vs. Enalapril) on Outcome and Adverse Events in Patients With Chronic Heart Failure

Medscape Today Headlines — Tue, 02 Aug 2011 11:04:20 +0100

Not leading with an ACE could affect clinical events and achieved dose for patients with heart failure. European Journal of Heart Failure (Source: Medscape Today Headlines)

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Med-Health Pharma, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 02 Aug 2011 05:00:00 +0100

Updated Date: Aug 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATEtablet, Film Coated [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 29 Jul 2011 05:00:00 +0100

Updated Date: Jul 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BCG/bisoprolol/rifampicin: BCG-induced tuberculosis, and bisoprolol/rifampicin interaction leading to hypertension and arrhythmia, in an elderly patient: case report

Reactions — Sun, 24 Jul 2011 19:59:43 +0100

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BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Med-Health Pharma, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 18 Jul 2011 05:00:00 +0100

Updated Date: Jul 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 11 Jul 2011 05:00:00 +0100

Updated Date: Jul 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Titration to Target Dose of Bisoprolol vs. Carvedilol in Elderly Patients With Heart FailureTitration to Target Dose of Bisoprolol vs. Carvedilol in Elderly Patients With Heart Failure

Medscape Today Headlines — Tue, 05 Jul 2011 11:04:21 +0100

Two proven beta-blockers are evaluated in terms of tolerability and optimal dosing to see if one surpasses the other in an elderly patient population. European Journal of Heart Failure (Source: Medscape Today Headlines)

Evaluation of clarithromycin lactobionate as a novel chiral selector for enantiomeric separation of basic drugs in capillary electrophoresis

Electrophoresis — Thu, 30 Jun 2011 23:00:00 +0100

In this study, clarithromycin lactobionate (CL), belonging to the group of macrolide antibiotics, was first investigated for its potential as a novel chiral selector in CE for enantiomeric separation of several basic drugs. As observed, CL allowed excellent separation of the enantiomers of metoprolol, atenolol, propranolol, bisoprolol, esmolol, ritodrine, and amlodipine, as well as partial enantioresolution of labetalol and nefopam. In addition, CL possesses advantages such as high solubility and low viscosity in the solvent and very weak UV absorption. In the course of this study, it was found that both migration times and enantioseparation of the basic drugs were influenced by several experimental parameters, e.g. selector concentration, the composition and pH of the BGE, the type and co...

Influence of order and type of drug (bisoprolol vs. enalapril) on outcome and adverse events in patients with chronic heart failure: a post hoc analysis of the CIBIS-III trial

European Journal of Heart Failure — Mon, 27 Jun 2011 23:00:00 +0100

Conclusion The order of drug administration plays an important role in whether CHF patients reach target doses of bisoprolol and enalapril. For both study drugs, the dose level reached was associated with baseline characteristics and adverse events. In CHF patients not treated with an ACE-I or a beta-blocker, the duration of monotherapy with either type of drug should be shorter than 6 months. (Source: European Journal of Heart Failure)

[Catecholaminergic ventricular tachycardia initially diagnosed as right ventricular outflow tract arrhythmia. Differential diagnosis of CPVT, LQTS and RVOT arrhythmia].

Kardiologia Polska — Sun, 26 Jun 2011 17:30:03 +0100

We described a case of 33 year-old woman with catecholaminergic polymorphic ventricular tachycardia (VT) with first presentation as syncope in age of 14. In subsequent ECGs premature ventricular contractions (PVC) with morphology of left bundle branch block-like pattern with positive R wave in leads: II, III and aVF what suggested PVC arising from right ventricular outflow tract were observed. Nonsustained VT was observed. No ventricular arrhythmias were induced during EPS. The 2 unsuccessful sessions of ablation were performed in the right ventricular outflow area. The exercise test provoked bidirectional VT. The adrenaline infusion provoked bidirectional nonsustained VT and the U wave amplitude augmentation. Betablocker was initiated (bisoprolol). The patient is free of symptoms, only si...

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Carvedilol for the Treatment of Benign Prostatic Hypertrophy in Patients With Heart Failure?

Journal of Cardiac Failure — Fri, 24 Jun 2011 04:00:00 +0100

We present a case where carvedilol was replaced with bisoprolol resulting in acute urinary retention. When carvediolol was reinstituted, the patient's symptoms of BPH resolved. Benign prostatic hypertrophy was later diagnosed by digital rectal exam. Six month after reinstituting the carvediolol, the patient remains free of his BPH symptoms. This case suggests that carvedilol may be considered for the management of HF with systolic dysfunction in patients with concomitant BPH thus eliminating the need for an α1-adrenergic blockers. (Source: Journal of Cardiac Failure)

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Eon Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 23 Jun 2011 05:00:00 +0100

Updated Date: Jun 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial

European Journal of Heart Failure — Tue, 24 May 2011 23:00:00 +0100

Conclusion Overall tolerability to target doses was comparable. The pattern of intolerance, however, was different: bradycardia occurred more often in the bisoprolol group, whereas pulmonary adverse events occurred more often in the carvedilol group. This study is registered with controlled-trials.com, number ISRCTN34827306. (Source: European Journal of Heart Failure)

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ZIAC (Bisoprolol Fumarate And Hydrochlorothiazide) Tablet, Film Coated [Teva Women'S Health, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 24 May 2011 05:00:00 +0100

Updated Date: May 24, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Film Coated [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 19 May 2011 05:00:00 +0100

Updated Date: May 19, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATEtablet, Film Coated [TEVA Pharmaceuticals USA Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 28 Apr 2011 05:00:00 +0100

Updated Date: Apr 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATEtablet [Rebel Distributors Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 13 Apr 2011 05:00:00 +0100

Updated Date: Apr 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Bisoprolol: Bradycardia leading to worsening heart failure in an elderly patient: case report

Reactions — Tue, 12 Apr 2011 16:15:37 +0100

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Bisoprolol: Fixed drug eruption in an elderly patient: case report

Reactions — Tue, 29 Mar 2011 16:01:27 +0100

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Zebeta (Bisoprolol Fumarate) - updated on RxList

RxList - New and Updated Drug Monographs — Tue, 29 Mar 2011 07:00:00 +0100

Zebeta (Bisoprolol Fumarate) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

ZIAC (Bisoprolol Fumarate And Hydrochlorothiazide) Tablet, Film Coated [Teva Women'S Health, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 10 Mar 2011 05:00:00 +0100

Updated Date: Mar 10, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Usefulness of transthoracic Doppler echocardiography for noninvasive assessment of coronary blood flow in a patient with symptomatic myocardial bridging

European Journal of Echocardiography — Tue, 08 Mar 2011 00:00:00 +0100

We report a case of MB in which transthoracic Doppler echocardiography was used to evaluate the long-term effect of beta-blocker therapy on abnormal coronary blood flow. In this case, beta-blocker therapy with bisoprolol (5.0 mg/day) for 1 month eliminated the patient's symptoms and normalized coronary blood flow through the tunnelled arterial segment. (Source: European Journal of Echocardiography)

[Catecholaminergic ventricular tachycardia initially diagnosed as right ventricular outflow tract arrhythmia. Differential diagnosis of CPVT, LQTS and RVOT arrhythmia.]

Kardiologia Polska — Thu, 03 Mar 2011 07:15:04 +0100

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Aggressive cutaneous vasculitis in a patient with chronic lymphatic leukemia following granulocyte colony stimulating factor injection: a case report

BioMed Central — Tue, 01 Mar 2011 00:00:00 +0100

Conclusion: The aim of this case report is to highlight the importance of monitoring patients on granulocytic colony-stimulating factor therapy, especially in the context of other conditions such as a hematological malignancy) that may lead to an adverse outcome. (Source: BioMed Central)

Population-Based Analysis of Class Effect of β Blockers in Heart Failure

The American Journal of Cardiology — Fri, 25 Feb 2011 00:00:00 +0100

The long-term use of β blockers has been shown to improve the outcomes of patients with heart failure (HF). However, it is still disputed whether this is a class effect, and, specifically, whether carvedilol or bisoprolol are superior to metoprolol. The present study was a comparative effectiveness study of β blockers for patients with HF in a population-based setting. We conducted an observational cohort study using the Quebec administrative databases to identify patients with HF who were prescribed a β blocker after the diagnosis of HF. We used descriptive statistics to characterize the patients by the type of β blocker prescribed at discharge. The unadjusted mortality for users of each β blocker was calculated using Kaplan-Meier curves and compared using the log-rank test. To accou...

ZIAC (Bisoprolol Fumarate And Hydrochlorothiazide) Tablet, Film Coated [Duramed Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 15 Feb 2011 05:00:00 +0100

Updated Date: Feb 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Evaluation of the Functional Status Questionnaire in Heart Failure: A Sub-study of the Second Cardiac Insufficiency Bisoprolol Survival Study (CIBIS-II)

Cardiovascular Drugs and Therapy — Thu, 03 Feb 2011 21:03:53 +0100

Conclusions The FSQ performed well in this study, provided additional information to the MLwHF questionnaire and allowed interesting comparisons with other chronic medical conditions. The FSQ may be a useful general QoL instrument for studies in CHF. Content Type Journal ArticlePages 1-9DOI 10.1007/s10557-011-6284-xAuthors Siobhan Gallanagh, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland UKDavide Castagno, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland UKBen Wilson, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland UKErland Erdmann, Department III of Internal Medicine, University of Cologne, Cologne, GermanyFaiez Zannad, University of Nancy, Nancy, FranceWil...

Changes in adiponectin expression in acute myocardial infarction rats and the significance of bisoprolol intervention.

Canadian Journal of Physiology and Pharmacology — Tue, 01 Feb 2011 00:00:00 +0100

Authors: Zhang S, He B, Goldstein S, Ge J, Wang Z, Ruiz G The aims of this study were to explore the changes in expression of myocardial adiponectin (APN), changes in serum APN, and the significance of bisoprolol intervention in acute myocardial infarction (AMI) rats. An AMI rat model was established for the purposes of this study and was used for analysis of serum APN as determined by ELISA. Changes in expression of myocardial APN mRNA and APN protein in AMI rats were determined via reverse transcriptase (RT)-PCR and immunohistochemistry. Serum APN concentration and APN protein expression of the myocardium decreased significantly in the AMI groups compared with the sham operation group, with the lowest serum APN and APN protein expression on day 7 after AMI. On days 7 and 10 after AMI...

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5-Fluorouracil-Induced Tako-Tsubo-Like Syndrome

Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy — Mon, 31 Jan 2011 00:00:00 +0100

We describe a 48-year-old man who developed acute coronary syndrome, thought to be similar to Tako-Tsubo syndrome, after receiving a chemotherapy regimen consisting of 5-fluorouracil, oxaliplatin, and calcium folinate (FOLFOX protocol) for colic adenocarcinoma. Approximately 24 hours after receiving his first cycle of chemotherapy, the patient, who did not have a history of cardiovascular disease, developed chest pain, with abnormal electrocardiographic results and a mildly increased troponin T level. Coronary angiography did not show any significant coronary lesions. Echocardiography revealed marked left ventricular dysfunction (left ventricular ejection fraction [LVEF] 15%) with severe hypokinesia in all apical and median segments. The patient was stabilized with the introduction of an i...

Bisoprolol: First report of oculomucocutaneous syndrome: case report

Reactions — Mon, 24 Jan 2011 17:42:36 +0100

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BISOPROLOL FUMARATEtablet, Film Coated [Aurobindo Pharma Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 21 Jan 2011 05:00:00 +0100

Updated Date: Jan 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATEtablet, Film Coated [TEVA Pharmaceuticals USA Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 13 Jan 2011 05:00:00 +0100

Updated Date: Jan 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Successful primary percutaneous coronary intervention in the first trimester of pregnancy

Catheterization and Cardiovascular Interventions — Tue, 04 Jan 2011 00:00:00 +0100

AbstractA 28‐year‐old patient, medical nurse, in 10th week of her second pregnancy suffered ventricular fibrillation just after entering the waiting room of the emergency department. After she was successfully defibrillated, electrocardiography revealed a large acute anteroseptolateral ST elevation myocardial infarction. Urgent coronarography was done (premedication with 300 mg of aspirin and 600 mg of clopidogrel) with 90 min door‐to‐balloon time. Proximal left anterior descending occlusion was found, primary percutaneous coronary intervention was done using Amazonia CroCo 3.0/12 bare‐metal stent, and Thrombolysis in Myocardial Infarction III flow was achieved. During the procedure, the patient was wrapped in lead apron. Because of postresuscitational agitation, procedure was do...

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BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Med Health Pharma, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 03 Jan 2011 05:00:00 +0100

Updated Date: Jan 3, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Differences Between β-Blockers in Patients With Chronic Heart Failure and Chronic Obstructive Pulmonary Disease: A Randomized Crossover Trial.

Congestive Heart Failure — Sat, 01 Jan 2011 00:00:00 +0100

Conclusions. Switching between β(1) -selective β-blockers and the nonselective β-blocker carvedilol is well tolerated but results in demonstrable changes in airway function, most marked in patients with COPD. Switching from β(1) -selective β-blockers to carvedilol causes short-term reduction of central augmented pressure and NT-ProBNP.-Jabbour A, Macdonald PS, Keogh AM, et al. Differences between β-blockers in patients with chronic heart failure and chronic obstructive pulmonary disease: a randomized crossover trial. J Am Coll Cardiol. 2010;55:1780-1787. PMID: 21272228 [PubMed - as supplied by publisher] (Source: Congestive Heart Failure)

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Eon Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 30 Dec 2010 05:00:00 +0100

Updated Date: Dec 30, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATEtablet, Coated [Eon Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 29 Dec 2010 05:00:00 +0100

Updated Date: Dec 29, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Rebel Distributors Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 20 Dec 2010 05:00:00 +0100

Updated Date: Dec 20, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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ZEBETA (Bisoprolol Fumarate) Tablet [Duramed Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 20 Dec 2010 05:00:00 +0100

Updated Date: Dec 20, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Bisoprolol better than carvedilol for prevention of AF post CABG?

NeLM - News — Wed, 15 Dec 2010 00:00:00 +0100

Source: Am J Cardiology Area: News Bisoprolol is more effective in preventing atrial fibrillation (AF) after coronary artery bypass grafting (CABG), according to a controlled trial. AF is common after CABG and contributes to morbidity and mortality: beta-blockers are generally recommended for prophylaxis. Cardioselective beta-blockers may have advantages in tolerability, and this trial aimed to compare the efficacy or cardioselective bisoprolol and non-selective carvedilol. It involved patients with reduced left ventricular function who had recently undergone CABG: they were randomised to receive double-blind bisoprolol or carvedilol titrated to maximum tolerated dose. Primary outcome was the rate of post-operative AF, and all patients had continuous ECG monitoring for 5 days a...

Comparison of Effectiveness of Carvedilol Versus Bisoprolol for Prevention of Postdischarge Atrial Fibrillation After Coronary Artery Bypass Grafting in Patients With Heart Failure

The American Journal of Cardiology — Fri, 03 Dec 2010 00:00:00 +0100

Atrial fibrillation (AF) occurs frequently soon after coronary artery bypass grafting (CABG) and often results in increased mortality and morbidity, particularly in patients with heart failure. New-onset AF is also a common event in the early period after discharge from a cardiac surgery clinic. Current guidelines recommend β blockers as first-line medication for the prevention of AF after CABG. In this prospective study, we investigated the effectiveness of the highly selective β1 receptor antagonist bisoprolol compared to the less selective β blocker carvedilol in preventing postdischarge AF after CABG in patients with decreased left ventricular function. Three hundred twenty patients (231 men, 89 women, mean age 66 ± 10 years) with ejection fraction (Source: The American Journal of ...

BISOPROLOL FUMARATEtablet, Coated [Sandoz Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 24 Nov 2010 05:00:00 +0100

Updated Date: Nov 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BCG/bisoprolol/rifampicin: BCG-induced tuberculosis, and bisoprolol/rifampicin interaction leading to hypertension and arrhythmia, in an elderly patient: case report

Reactions — Wed, 24 Nov 2010 04:27:18 +0100

(Source: Reactions)

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Microbial Transformation of Pharmaceuticals Naproxen, Bisoprolol, and Diclofenac in Aerobic and Anaerobic Environments.

Archives of Environmental Contamination and Toxicology — Wed, 17 Nov 2010 00:00:00 +0100

In this study, the transformations of diclofenac (DCF), naproxen (NPX), and bisoprolol (BSP) were studied under aerobic and anaerobic conditions using inocula taken from activated and digested sludge processes, respectively. Whereas concentration decays were monitored by LC-tandem mass spectrometry, oxygen consumption and methane production were used for the evaluation of the performance of overall conditions. DCF was recalcitrant against both aerobic and anaerobic biotransformation. More than one third of the BSP disappeared under aerobic conditions, whereas only 14% was anaerobically biotransformed in 161 days. Under aerobic conditions, complete removal of NPX was evident within 14 days, but anaerobic transformation was also efficient. Formation of 6-O-desmethylnaproxen, a previously r...

Urinary Bladder Tuberculosis and Bacillus Calmette-Guérin Instillation: Reduced Efficacy of Bisoprolol in Hypertension.

Aktuelle Urologie — Mon, 01 Nov 2010 00:00:00 +0100

CONCLUSION: Rifampicin is one of the best known potent enzyme inducing drugs. It strongly induces the expression of cytochrome P450 3A4 in the liver. The enzyme induction enhance the hepatic bisoprolol metabolism, hence the metabolic clearance of the drug increased. The maximal plasma level of bisoprolol decrease and in our use the arterial hypertension could not be treated sufficiently. It is well known that half the dose of bisoprolol undergoes oxidative metabolism in the liver and the rest eliminated unchanged in the kidney. A dosage adjustment of bisoprolol is necessary if the clinical status of the patient requires treatment with the antituberculosis drug rifampicin. PMID: 21082517 [PubMed - as supplied by publisher] (Source: Aktuelle Urologie)

Cleanup strategies and advantages in the determination of several therapeutic classes of pharmaceuticals in wastewater samples by SPE-LC-MS/MS.

Analytical and Bioanalytical Chemistry — Tue, 19 Oct 2010 23:00:00 +0100

Authors: Sousa MA, Gonçalves C, Cunha E, Hajšlová J, Alpendurada MF This work describes the development and validation of an offline solid-phase extraction with simultaneous cleanup capability, followed by liquid chromatography-(electrospray ionisation)-ion trap mass spectrometry, enabling the concurrent determination of 23 pharmaceuticals of diverse chemical nature, among the most consumed in Portugal, in wastewater samples. Several cleanup strategies, exploiting the physical and chemical properties of the analytes vs. interferences, alongside with the use of internal standards, were assayed in order to minimise the influence of matrix components in the ionisation efficiency of target analytes. After testing all combinations of adsorbents (normal-phase, ion exchange and mixed compo...

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (Bisoprolol Fumarate And Hydrochlorothiazide) Tablet [Unichem Pharmaceuticals (USA), Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 15 Oct 2010 05:00:00 +0100

Updated Date: Oct 15, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effects of bisoprolol and cilazapril on the central retinal artery blood flow in patients with essential hypertension-preliminary results.

Upsala Journal of Medical Sciences — Tue, 21 Sep 2010 23:00:00 +0100

Conclusion. Systemic application of beta-blockers may unfavourably disturb the ocular blood flow. PMID: 20858158 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (Bisoprolol Fumarate And Hydrochlorothiazide) Tablet, Coated [AvKARE, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 17 Sep 2010 05:00:00 +0100

Updated Date: Sep 17, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Efficacy of beta-blocker therapy in symptomatic athletes with exercise-induced intra-ventricular gradients

BioMed Central — Wed, 01 Sep 2010 23:00:00 +0100

Background: Upright exercise stress echocardiography (SE) induces significant intraventricular gradient (IVG) and systolic anterior motion (SAM) in a large proportion of symptomatic athletes, who may therefore benefit from a negative inotropic therapy.The purpose of the present study was to assess the effect of chronic oral beta-blocker therapy on the occurrence of exercise-induced IVG and mitral valve SAM, in symptomatic athletes. Methods: We enrolled 35 symptomatic athletes (age: 23+-11 years) with IVG (>30 mmHg) during SE off therapy. All repeated SE on chronic oral beta-blocker therapy (atenolol up to 50 mg, bisoprolol up to 10 mg, or metoprolol up to 100 mg daily according to physician-driven choice). Results: On therapy, there was during SE a reduction in IVG (35 off vs 17 on beta-bl...

A Distracting Stroke and the Erythematous Flag

The American Journal of Medicine — Fri, 27 Aug 2010 06:37:47 +0100

An 81-year-old woman presented with sudden-onset right-sided weakness and a global language disorder. Her medical history was notable for well-controlled hypertension, duodenal ulceration, sclerotic cataracts, a traumatic amputation of the distal phalanx of her right middle digit, and cigarette smoking. Medications on admission comprised aspirin, bendroflumethiazide, nifedipine, and bisoprolol; no recent changes to medication had occurred. She was a retired factory worker who lived alone and, before admission, had been independent. (Source: The American Journal of Medicine)

Optimization and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the determination of 13 top-prescribed pharmaceuticals in influent wastewater.

Analytical and Bioanalytical Chemistry — Mon, 23 Aug 2010 23:00:00 +0100

Authors: van Nuijs AL, Tarcomnicu I, Simons W, Bervoets L, Blust R, Jorens PG, Neels H, Covaci A A sensitive hydrophilic interaction liquid chromatography (HILIC)-tandem mass spectrometry method was developed and validated for the analysis of 13 pharmaceuticals (omeprazole, pantoprazole, ranitidine, citalopram, fluoxetine, paroxetine, venlafaxine, tramadol, nebivolol, metoprolol, atenolol, bisoprolol and metformin) in influent wastewater. The analytes were selected from the list of top-sold prescription pharmaceuticals in Belgium. The HILIC separation was optimised to achieve quantification of all analytes in real influent wastewater samples where other compounds, mainly metabolites of some of the pharmaceuticals, were found to interfere even with mass-spectrometric detection in multip...

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Congestion in chronic systolic heart failure is related to renal dysfunction and increased mortality

European Journal of Heart Failure — Fri, 20 Aug 2010 16:10:15 +0100

Conclusion Signs and symptoms of congestion are associated with renal impairment and are independent determinants of prognosis in patients with CHF. (Source: European Journal of Heart Failure)

Replacement of carvedilol for propranolol in patients with heart failure

Arquivos Brasileiros de Cardiologia — Thu, 19 Aug 2010 05:27:29 +0100

CONCLUSION: Our results indicate that replacement of carvedilol for propranolol in patients with heart failure is not associated with deterioration of the ejection fraction, functional capacity, quality of life, and other cardiovascular variables related to autonomic and blood pressure control., PP.0-0). (Source: Arquivos Brasileiros de Cardiologia)

Extraction and preconcentration of beta-blockers in human urine for analysis with high performance liquid chromatography by means of carrier-mediated liquid phase microextraction.

Talanta — Thu, 05 Aug 2010 15:57:52 +0100

Authors: Zhang L, Su X, Zhang C, Ouyang L, Xie Q, Ma M, Yao S A novel method was developed for the analysis of four beta-blockers, namely sotalol, carteolol, bisoprolol, and propranolol, in human urine by coupling carrier-mediated liquid phase microextraction (CM-LPME) to high performance liquid chromatography (HPLC). By adding an appropriate carrier in organic phase, simultaneous extraction and enrichment of hydrophilic (sotalol, carteolol, and bisoprolol) and hydrophobic (propranolol) drugs were achieved. High enrichment factors were obtained by optimizing the compositions of the organic phase, the acceptor solution, the donor solution, the stirring rate, and the extraction time. The linear ranges were from 0.05 to 10.0mgL(-1) for sotalol and carteolol, and from 0.05 to 8.0mgL(-1) fo...

Unichem Labs gets USFDA nod for hypertension tabs

The Economic Times Healthcare and Biotech News — Fri, 30 Jul 2010 06:53:37 +0100

Unichem Laboratories has received US FDA approval for bisoprolol fumarate and hydrochlorothiazide in tablet form, the drug regulator's website showed on Friday. Both drugs are used in the treatment of hypertension. (Source: The Economic Times Healthcare and Biotech News)

Proarrhythmia in the setting of acute ST-segment elevation

Journal of Electrocardiology — Mon, 19 Jul 2010 23:00:00 +0100

An 84-year-old woman with persistent atrial fibrillation was admitted to the emergency department complaining of repeated attacks of resting angina, palpitations, and dizziness. She was on oral anticoagulation, amiodarone, and bisoprolol. Transthoracic echocardiography revealed normal left ventricular ejection fraction and dilated left atrium. Ambulatory Holter monitoring revealed several episodes of short-coupled premature ventricular complexes and short runs of polymorphic ventricular tachycardia, initiated by an “R-on-T” phenomenon without QT interval prolongation or short-long-short sequences. All episodes were exclusively associated with ST-segment elevation (). Serum electrolytes and biochemical markers for myocardial damage were normal in 2 consecutive blood samples. Coronary an...

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Amiodarone/bisoprolol/digoxin: Hypothyroidism, bradycardia and digoxin toxicity in an elderly patient: case report

Reactions — Tue, 29 Jun 2010 05:33:09 +0100

(Source: Reactions)

Chronotropic Incompentence and Functional Capacity in Chronic Heart Failure: No Role of β-Blockers and β-Blocker Dose

Cardiovascular Therapeutics — Thu, 10 Jun 2010 23:00:00 +0100

Conclusions: [Delta]HR is a powerful predictor of CHF severity regardless of the presence of [beta]-blocker therapy and of [beta]-blocker daily dose. (Source: Cardiovascular Therapeutics)

Effect on Mode of Death of Heart Failure Treatment Started with Bisoprolol Followed by Enalapril, Compared to the Opposite Order: Results of the Randomized CIBIS III Trial

Cardiovascular Therapeutics — Tue, 01 Jun 2010 23:00:00 +0100

Conclusion: Initiating therapy with bisoprolol compared to enalapril decreased the risk of sudden death during the first year in this mild systolic CHF cohort. This was somewhat offset by an increase in pump failure deaths in the bisoprolol-first cohort. (Source: Cardiovascular Therapeutics)

Effects of β-blockers on ventilation efficiency in heart failure

American Heart Journal — Mon, 31 May 2010 23:00:00 +0100

Conclusions: Reduction of hyperventilation, with improvement of VE efficiency during exercise (reduction of VE/Vco2 slope and increase of maximum end-tidal CO2 pressure), is specific to carvedilol (β1-β2 unselective blocker) and not to bisoprolol (β1-selective blocker). (Source: American Heart Journal)

Improved survival with bisoprolol in patients with heart failure and renal impairment: an analysis of the cardiac insufficiency bisoprolol study II (CIBIS-II) trial

European Journal of Heart Failure — Mon, 24 May 2010 15:52:41 +0100

Conclusion The beneficial effects of bisoprolol on mortality and hospitalization for worsening heart-failure were not modified by baseline eGFRBSA. Renal impairment should not prevent the use of bisoprolol in patients with HF. (Source: European Journal of Heart Failure)

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Determination of five beta-blockers in wastewaters by coupled-column liquid chromatography and fluorescence detection.

Analytica Chimica Acta — Wed, 05 May 2010 04:00:50 +0100

Authors: Parrilla VÃ¡zquez P, MartÃnez Galera M, Serrano Guirado A, Parrilla VÃ¡zquez MM A simple multidimensional system for direct injection of large volumes has been developed for the determination of five beta-blockers (atenolol, nadolol, metoprolol, bisoprolol and betaxolol) in wastewater using fluorescence detection. A C18 50 mm x 4.6 mm i.d. column coupled to a RP Amide C16 150 mm x 4.6 mm i.d. column for analyte clean-up and determination were used, respectively. The capability of a first column for eliminating large, interfering molecules, combined with an optimised, coupled-column liquid chromatography separation procedure (LC-LC), large volume injection (LVI) and fluorescence detection (FD), gave excellent sensitivity and selectivity for the target analytes. The LVI-L...

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDEtablet, Coated [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 04 May 2010 05:00:00 +0100

Updated Date: May 4, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Is there a Failure to Optimize theRapy in anGina pEcToris (FORGET) study?

QJM — Thu, 29 Apr 2010 05:50:46 +0100

Conclusions: A significant proportion of the patients with chronic stable angina undergoing elective PCI did not achieve therapeutic targets for lipid, BP and HR control. Over 50% of patients did not receive adequate HR lowering anti-anginal therapy to achieve recommended target resting HR. (Source: QJM)

Differences Between Beta-Blockers in Patients With Chronic Heart Failure and Chronic Obstructive Pulmonary Disease: A Randomized Crossover Trial

Journal of the American College of Cardiology — Thu, 22 Apr 2010 12:52:46 +0100

Conclusions: Switching between β1-selective beta-blockers and the nonselective beta-blocker carvedilol is well tolerated but results in demonstrable changes in airway function, most marked in patients with COPD. Switching from β1-selective beta-blockers to carvedilol causes short-term reduction of central augmented pressure and N-terminal pro-hormone brain natriuretic peptide. (Comparison of Nonselective and Beta1-Selective Beta-Blockers on Respiratory and Arterial Function and Cardiac Chamber Dynamics in Patients With Chronic Stable Congestive Cardiac Failure; Australian New Zealand Clinical Trials Registry, ACTRN12605000504617) (Source: Journal of the American College of Cardiology)

Beta-1-Selective Beta-Blockers Safer for Heart Failure Patients With COPD

Medscape Cardiology Headlines — Tue, 20 Apr 2010 17:04:41 +0100

The nonselective beta-blocker carvedilol and the beta-1-selective beta-blockers metoprolol succinate and bisoprolol have significantly different treatment effects in patients with chronic heart failure and chronic obstructive pulmonary disease (COPD), a new study shows. Reuters Health Information (Source: Medscape Cardiology Headlines)

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Switching Beta-Blockers Tied to Airway Function Changes

Modern Medicine — Mon, 19 Apr 2010 23:00:00 +0100

Switching between the nonselective beta-blocker carvedilol and the β1-selective beta-blockers metoprolol succinate and bisoprolol is well tolerated but leads to changes in airway function in patients with chronic heart failure, particularly those with chronic obstructive pulmonary disease, according to research published in the April 27 issue of the Journal of the American College of Cardiology. (Source: Modern Medicine)

Inadequate control of heart rate in patients with stable angina: results from the European Heart Survey

Postgraduate Medical Journal — Tue, 30 Mar 2010 09:03:33 +0100

Conclusion Control of ischaemic symptoms through heart rate modification in patients with angina is currently inadequate, both by primary referring physicians and cardiologists. Given the adverse outcome associated with higher resting heart rates in this as in other studies, and the availability of specific HR reducing strategies, attention should be given to achieving optimal HR control. (Source: Postgraduate Medical Journal)

Comparative Effects of Carvedilol vs Bisoprolol for Severe Congestive Heart Failure.

Circulation Journal — Mon, 29 Mar 2010 23:00:00 +0100

Conclusions: Our data suggest that the 2 beta-blockers are equally effective in the improvement of severe HF, but bisoprolol shows favorable effects in patients with AF. PMID: 20354334 [PubMed - as supplied by publisher] (Source: Circulation Journal)

Multimorbidity and polypharmacy: which betablocker to use in relation to the pharmacokinetic profile and interaction potential.

Arzneimittel-Forschung — Thu, 25 Mar 2010 16:34:03 +0100

Authors: Wehling M Betablockers still represent widely prescribed drugs as they cover a wide spectrum of cardiovascular indications. Obviously, it is not trivial which betablocker to choose as they differ both with regard to their pharmacodynamic (e. g. selective vs. nonselective, beta vs. beta + alpha blocking activities) and pharmacokinetic profiles. Latter is largely governed by the metabolic properties, and, thus, their excretion route (renal or biliary route in unchanged or metabolized form). In the elderly population, the stability of plasma concentrations is particularly essential as this population has smaller compensatory tolerance to concentration variations than younger patients. The interaction potential of betablockers with regard to drug-drug, gene polymorphism-drug, excr...

BISOPROLOL FUMARATEtablet, Film Coated [Mylan Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 08 Mar 2010 05:00:00 +0100

Updated Date: Mar 8, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Comparison of ivabradine plus beta-blockers versus beta -blocker therapy only.

Cardiovascular Journal of Africa — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Aalbers J A study of patients with stable angina and moderate left ventricular systolic dysfunction has shown that the addition of ivabradine to bisoprolol produced additional anti-anginal and anti-ischaemic effects that were not achieved with up-titration of bisoprolol. This indicative study is of importance to clinicians as they are frequently faced with patients on beta-blockers who are not able to tolerate the full target dose, as defined from evidencebased clinical trials. PMID: 20532439 [PubMed - in process] (Source: Cardiovascular Journal of Africa)

Beta-blockers and heart failure.

Indian Heart J — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Cruickshank JM The life-time risk of developing HF is about 20% (40% if hypertension present). With increasing longevity in the developed world the burden of HF (hospitalisation) is set to increase over the next 10-20 years. CAD and hypertension are the two main causes of HF; CAD (and obesity) in the case of systolic HF and hypertension in the case of diastolic HF (mainly in the elderly). BB have become the corner-stone (alongside ACE-inhibitors) in the treatment of systolic HF. Bisoprolol, metoprolol and carvedilol (on an ACE-inhibitor background) have reduced all-cause death by 34-5%. The presence of intrinsic sympathomemetic activity (xamoterol, bucindolol, nebivolol) diminishes efficacy in the treatment of systolic HF. First-line bisoprolol has proved "non-inferior" to fir...

BISOPROLOL FUMARATEtablet, Film Coated [Aurobindo Pharma Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 08 Jan 2010 05:00:00 +0100

Updated Date: Jan 8, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cilazapril increases plasma ghrelin concentration in obese patients with arterial hypertension.

Endokrynologia Polska — Fri, 01 Jan 2010 00:00:00 +0100

Conclusions: 1. Our data do not support the major role of ghrelin in blood pressure regulation in obesity. 2. An increase of plasma ghrelin concentration after treatment with cilazapril was observed. (Pol J Endocrinol 2010; 61 (1): 21-27). PMID: 20205100 [PubMed - in process] (Source: Endokrynologia Polska)

Bisoprolol and heart failure: new frontiers.

Indian Heart J — Fri, 01 Jan 2010 00:00:00 +0100

This article will summarize evidence for the efficacy of bisoprolol in the treatment of HF. PMID: 21180027 [PubMed - in process] (Source: Indian Heart J)

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Low-dose peri-operative beta-blockade does not seem to increase stroke risk

NeLM - News — Thu, 10 Dec 2009 00:00:00 +0100

Source: Am J Cardiology Area: News A retrospective analysis of three trials studying beta-blockade to prevent cardiovascular events in at-risk patients undergoing non-cardiac surgery suggests that the regimen studied did not significantly increase stroke risk. Peri-operative beta-blockade has been widely used in patients at risk of cardiovascular events who are undergoing non-cardiac surgery, as evidence suggests that it reduces the risk of serious cardiac events. A large controlled trial, however (the POISE trial; Lancet 2008; 371: 1839-47), found that the regimen used in that study, metoprolol m/r 200mg daily, was associated with an increased risk of stroke. This cast doubt on the safety of such treatment. An earlier, smaller study (DECREASE-I) had previously shown benefit fr...

New developments in the preoperative evaluation and perioperative management of coronary artery disease in patients undergoing vascular surgery

Journal of Vascular Surgery — Thu, 03 Dec 2009 00:00:00 +0100

Conclusion: Routine stress testing should not be performed before VS. The Lee index should be used to stratify risk in patients undergoing VS. Patients with ≥3 risk factors or active cardiac conditions should undergo stress testing, if VS can be delayed. All VS patients, except those with 0 risk factors, should be considered for a β-blocker (bisoprolol, 2.5-5 mg/d started 1 month before VS, titrated to a pulse (Source: Journal of Vascular Surgery)

Atrial tachycardia with 1:1 atrioventricular conduction precipitated by propafenone

Emergency Medicine Journal — Tue, 24 Nov 2009 18:04:19 +0100

A 58-year-old man presented to the emergency department with sudden onset rapid palpitations and significant presyncope while walking on the flat. The previous day he had undergone DC cardioversion for atrial fibrillation (AF) which had been initially successful. However, 6 h after cardioversion he was aware of intermittently raised but regular heart rates. On arrival at the emergency department (ED) he was well with no haemodynamic compromise. The ECG showed an atrial tachycardia instead of AF. Medications consisted of propafenone 300 mg twice daily, bisoprolol 5 mg at night and warfain. Bisoprolol was increased to 5 mg twice daily and he was discharged with a plan for outpatient ablation. He collapsed in the hospital car park with rapid palpations, chest tightness and vagal symptoms. On ...

BISOPROLOL FUMARATEtablet, Film Coated [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 23 Nov 2009 05:00:00 +0100

Updated Date: Nov 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZEBETA (Bisoprolol Fumarate) Tablet [Duramed Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 19 Nov 2009 05:00:00 +0100

Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Impact of Prophylactic β-Blocker Therapy to Prevent Stroke After Noncardiac Surgery

The American Journal of Cardiology — Mon, 16 Nov 2009 00:00:00 +0100

In conclusion, with a low-dose bisoprolol regimen started ≥30 days before surgery, no association was observed between β-blocker use and postoperative stroke. (Source: The American Journal of Cardiology)

Differential Effects of Oral {beta} Blockade on Cardiovascular and Sympathetic Regulation

Journal of Cardiovascular Pharmacology and Therapeutics — Wed, 11 Nov 2009 02:11:41 +0100

In patients with hypertension, β blockade decreases muscle sympathetic nerve activity (MSNA; micrographic technique) expressed in burst frequency (burst/min) but does not affect MSNA expressed in burst incidence (burst/100 heart beats), because reductions in blood pressure (BP) upon each diastole continue to deactivate the arterial baroreceptors, but at a slower heart rate (HR). We studied the effects of oral β blockade on MSNA and baroreflex sensitivity (BRS) in normal participants. Bisoprolol (5 mg, 1 week) was administered in 10 healthy young adults, using a double-blind, placebo-controlled, randomized cross-over study design. The beat-to-beat mean RR interval (RR) and systolic blood pressure (SBP) series were analyzed by power spectral analysis and power computation over the ...

Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failure

NeLM - Disease Focused Reviews — Fri, 06 Nov 2009 00:00:00 +0100

Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: This review concluded that the magnitude of heart rate reduction was statistically significantly associated with the survival benefit of beta-blockers in heart failure, but the dose of beta-blocker was not. The majority of the review process and the synthesis were well conducted. Despite the absence of a validity assessment, the conclusions appear likely to be reliable. [Included studies assessed metoprolol, carvedilol, bisoprolol, bucindolol, nebivolol and atenolol. ] CRD Commentary: The review question was clear and was supported by specific inclusion criteria. The authors searched several relevant databases and included attempts to locate unpublished studies in their strategy. This, together with the lack of languag...

Differential effects of β-adrenoreceptor antagonists on central and peripheral blood pressure at rest and during exercise

British Journal of Clinical Pharmacology — Thu, 05 Nov 2009 00:00:00 +0100

CONCLUSIONS Despite reducing brachial blood pressure, acute [beta]-adrenoreceptor blockade in man at rest and during exercise does not reduce central blood pressure. (Source: British Journal of Clinical Pharmacology)

Low-dose Fixed Combination of Bisoprolol/Hydrochlorothiazide as First Line for Hypertension: A Review of the Rationale and Clinical Evidence

Angiology — Thu, 22 Oct 2009 08:29:10 +0100

Essential hypertension is a heterogeneous multifactorial disease. Data from the National Health and Nutritional Examination Survey and from the World Health Organization have clearly demonstrated that, worldwide, less than 30% of hypertensive patients are adequately controlled by our currently accepted blood pressure goals. Although monotherapy is often unable to achieve blood pressure goals, the use of fixed low-dose combination drugs as alternative treatment seems to be related to a better antihypertensive efficacy and higher response rates in the low range of doses as the result of complementary mechanisms of antihypertensive effects. Indeed clinical trials have shown that initial low-dose combination therapy is superior as compared with treatment by the stepped-care and the sequential ...

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Bisoprolol: First report of a fixed drug eruption: case report

Reactions — Mon, 19 Oct 2009 13:04:56 +0100

(Source: Reactions)

Liquid chromatography tandem mass spectrometry method for determination of bisoprolol in human plasma using d5-bisoprolol as the internal standard.

Biomedical Chromatography : BMC — Sun, 04 Oct 2009 23:00:00 +0100

Authors: Liu GY, Wang W, Jia JY, Lu C, Liu YM, Zhang MQ, Liu Y, Li SJ, Yu C A simple, reliable and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) protocol was developed and validated for quantification of bisoprolol in human plasma. The sample was pretreated with a simple procedure of protein precipitation and an isotope-labeled d5-bisoprolol was used as internal standard. The chromatographic separation was performed on a Capcell Pak C(18) MG III column (100 mm x 2.0 mm, 5 microm). The protonated ion of the analyte was detected in positive ionization by multiple reaction monitoring mode. The mass transition pairs of m/z 326.3 --> 116.3 and m/z 331.3 --> 121.3 were used to detect bisoprolol and the internal standard, respectively. Linearity, accuracy, precisio...

Respiratory Effects of β-blocker Therapy in Heart Failure

Cardiovascular Drugs and Therapy — Tue, 29 Sep 2009 16:56:52 +0100

In conclusion, it is possible to use β-blockers in HF patients even in the presence of lung function impairment, but their use should be guided by a combination of lung function evaluation and knowledge of the pharmacological properties of each molecule Content Type Journal ArticleDOI 10.1007/s10557-009-6195-2Authors Piergiuseppe Agostoni, Università di Milano Centro Cardiologico Monzino-IRCCS, Istituto di Cardiologia via Parea 4 20138 Milan ItalyPietro Palermo, Università di Milano Centro Cardiologico Monzino-IRCCS, Istituto di Cardiologia via Parea 4 20138 Milan ItalyMauro Contini, Università di Milano Centro Cardiologico Monzino-IRCCS, Istituto di Cardiologia via Parea 4 20138 Milan Italy Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206...

BISOPROLOL FUMARATE TABLETS (Bisoprolol Fumarate) Tablet [Unichem Pharmaceuticals (USA), Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Sep 2009 05:00:00 +0100

Updated Date: Sep 22, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

ZIAC (Bisoprolol Fumarate And Hydrochlorothiazide) Tablet, Film Coated [Duramed Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 11 Sep 2009 05:00:00 +0100

Updated Date: Sep 11, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Interaction of beta-blockers with the renal uptake transporter OCT2

Diabetes, Obesity and Metabolism — Wed, 09 Sep 2009 23:00:00 +0100

Conclusion: These in vitro results demonstrate that alterations of uptake transporter function by beta-blockers have to be considered as potential mechanisms underlying drug[ndash]drug interactions in the kidney. (Source: Diabetes, Obesity and Metabolism)

bisoprolol, Zebeta

MedicineNet Heart General — Wed, 02 Sep 2009 07:00:00 +0100

Title: bisoprolol, ZebetaCategory: MedicationsCreated: 3/26/1998 2:30:00 PMLast Editorial Review: 9/2/2009 (Source: MedicineNet Heart General)

The effectiveness of collaborative medicine reviews in delaying time to next hospitalization for patients with heart failure in the practice setting: results of a cohort study.

Australian Family Physician — Tue, 01 Sep 2009 00:00:00 +0100

CONCLUSIONS: Medicines review in the practice setting is effective in delaying time to next hospitalization for heart failure in those treated with heart failure medicines. PMID: 19808372 [PubMed - indexed for MEDLINE] (Source: Australian Family Physician)

Survival among patients with left ventricular systolic dysfunction treated with atenolol.

Congestive Heart Failure — Mon, 31 Aug 2009 23:00:00 +0100

Authors: Kapoor JR, Heidenreich PA Metoprolol succinate, carvedilol, and bisoprolol are approved for use in heart failure. Other beta-blockers have been found to be inferior (metoprolol tartrate) or have not been studied (atenolol). The authors compared all-cause mortality following treatment with either atenolol, carvedilol, or metoprolol tartrate for 974 patients with left ventricular function < or =40%. The unadjusted mortality at 6 months was lower with atenolol (3.2%) and carvedilol (4.2%) when compared with metoprolol tartrate (7.5%, P< or =.039). However, patients with atenolol were older but had less prior heart failure. After adjustment for the propensity to be treated with atenolol, patients actually treated with atenolol had a significantly lower risk of death compared...

The effect of an evening dose of a long-acting beta-blocker on the autonomic tone in patients with congestive heart failure.

Kardiologia Polska — Mon, 31 Aug 2009 23:00:00 +0100

Conclusion: An evening dose of a beta-blocker is more effective than a morning dose in reversing adverse changes in the autonomic nervous system activity in CHF patients. PMID: 19838952 [PubMed - as supplied by publisher] (Source: Kardiologia Polska)

Bisoprolol: Exacerbation of psoriasis: case report

Reactions — Mon, 24 Aug 2009 12:02:41 +0100

(Source: Reactions)

Unichem gets FDA nod to market hypertension drug

The Economic Times Healthcare and Biotech News — Thu, 20 Aug 2009 14:18:35 +0100

Unichem Laboratories Ltd said it has received the US Food and Drug Administration approval to sell its anti hypertension drug, bisoprolol fumarate, tablets in 5mg and 10 mg doses. (Source: The Economic Times Healthcare and Biotech News)

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A New Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Bisoprolol in Human Plasma Samples

Journal of Biomedicine and Biotechnology — Wed, 19 Aug 2009 11:38:14 +0100

Liquid chromatography (LC) coupled with mass spectrometry (MS) detection is one of the most powerful analytical tools for organic compound analysis. The advantages of using LC/MS methods over HPLC methods include: selectivity, chromatographic integrity, peak assignment, structural information, and rapid method development. In this paper, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of bisoprolol in human plasma samples, using metoprolol as internal standard and liquid-liquid extraction procedure. The assay has proven to be sensitive, specific and reproducible, suitable to determine the bisoprolol concentration, following a single oral administration of a 10 mg bisoprolol tablet in 22 healthy volunteers,...

Changes in components of left ventricular mechanics under selective beta-1 blockade: insight from traditional and new technologies in echocardiography

European Journal of Echocardiography — Mon, 10 Aug 2009 23:00:00 +0100

Conclusion In hypertensive subjects with preserved LV EF, parameters of longitudinal LV systolic mechanics may not reflect the LV myocardial contractility status in steady-state conditions under short-term treatment with β1-block. (Source: European Journal of Echocardiography)

One-Year Renal and Cardiac Effects of Bisoprolol versus Losartan in Recently Diagnosed Hypertensive Patients: A Randomized, Double-Blind Study

Clinical Drug Investigation — Mon, 10 Aug 2009 10:20:09 +0100

(Source: Clinical Drug Investigation)

Bisoprolol/doxazosin/valsartan: Sarcoidosis to anhydrous colloidal silica excipient: case report

Reactions — Sun, 26 Jul 2009 10:51:00 +0100

(Source: Reactions)

Clinical trials update from the European Society of Cardiology heart failure meeting 2009: CHANCE, B-Convinced, CHAT, CIBIS-ELD, and Signal-HF

European Journal of Heart Failure — Thu, 23 Jul 2009 23:00:00 +0100

This paper provides information and a commentary on trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the annual meeting of the Heart Failure Association of the European Society of Cardiology held in Nice. The CHANCE study showed a substantial reduction in morbidity and mortality in a randomized controlled trial (RCT) of a multidisciplinary management programme for patients with chronic heart failure in Russia. Data from the B-Convinced study, also an RCT, suggest that continuation of beta-blocker (BB) therapy in patients hospitalized with worsening heart failure may be associated with improved outcomes when compared with treatment discontinuation. The CHAT study suggests that telephone support can improve prognosis in heart failure patients li...

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Effects of AT1 receptor and beta1 receptor blocking on blood pressure, peripheral hemodynamic and lipid profile in statin-treated hypertensive hypercholesterolemic patients

Fundamental and Clinical Pharmacology — Wed, 24 Jun 2009 23:00:00 +0100

Recent evidences suggest a relationship between angiotensin 1 (AT1) receptor gene expression and low density lipoprotein cholesterol (LDL-C) plasma level. We enrolled 16 untreated hypertensive hypercholesterolemic patients (57.4 ± 7 years old) in a randomized, single-blind, cross-over design. All the patients were allocated to treatment with simvastatin 20 mg/day for 2 weeks, then randomly assigned to telmisartan (40[ndash]80 mg/day) or bisoprolol (5[ndash]10 mg/day). After 4 weeks the antihypertensive drugs have been withdrawn for a wash-out period of 2 weeks when they were treated with simvastatin alone, then they have been allocated to the alternative antihypertensive treatment for four additional weeks. We measured: systolic (SBP) and diastolic BP (DBP), 24-h mean BP (MBP), Baseline a...

Bisoprolol in patients with heart failure and moderate to severe chronic obstructive pulmonary disease: a randomized controlled trial

European Journal of Heart Failure — Tue, 23 Jun 2009 23:00:00 +0100

Conclusion Initiation of bisoprolol in patients with HF and concomitant moderate or severe COPD resulted in a reduction in FEV1. However, symptoms and quality of life were not impaired. (Source: European Journal of Heart Failure)

Use of a Nurse-led Intervention to Optimize Beta-blockade for Reducing Cardiac Events After Major Noncardiac Surgery

Medscape Critical Care Headlines — Mon, 08 Jun 2009 21:00:56 +0100

Does using an algorithm-based strategy for bisoprolol titration reduce cardiac events after major non-cardiac surgery? American Heart Journal (Source: Medscape Critical Care Headlines)

Reversed-phase high-performance liquid chromatographic enantioresolution of six beta-blockers using dinitrophenyl-l-Pro-N-hydroxysuccinimide ester, N-succinimidyl-(S)-2-(6-methoxynaphth-2-yl) propionate and twelve variants of Sanger's reagent as chiral derivatizing reagents.

Biomedical Chromatography : BMC — Sun, 31 May 2009 23:00:00 +0100

Authors: Bhushan R, Tanwar S Twelve chiral derivatizing reagents (CDRs) were synthesized by substituting one of the fluorine atoms in 1,5-difluoro-2,4-dinitrobenzene (DFDNB) with three optically pure amines [(R)-(-)-1-cyclohexylethylamine, (+)-dehydroabietylamine and (S)-(-)-alpha,4-dimethylbenzylamine], six amino acid amides [l-Ala-NH(2), l-Phe-NH(2), l-Val-NH(2), l-Leu-NH(2), l-Met-NH(2) and d-Phg-NH(2)] and three amino acids [l-Ala, l-Val and l-Leu]. In addition, dinitrophenyl-l-Pro-N-hydroxysuccinimide ester and N-succinimidyl-(S)-2-(6-methoxynaphth-2-yl) propionate were also synthesized and used as CDR. Keeping in view the presence of an amino group, diastereomers of six beta-blockers (atenolol, propranolol, bisoprolol, metoprolol, salbutamol, and carvedilol) were synthesized by r...

Effects of Telmisartan and Bisoprolol on Blood Pressure, Peripheral Haemodynamic and Lipid Profile in Statin-Treated Hypertensive Hypercholesterolaemic Patients

High Blood Pressure — Mon, 25 May 2009 02:30:57 +0100

(Source: High Blood Pressure)

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A cutoff point for peak oxygen consumption in the prognosis of heart failure patients with beta-blocker therapy

International Journal of Cardiology — Mon, 25 May 2009 00:00:00 +0100

Abstract: Purpose: Beta-blockers (BB) have shown to improve outcomes among heart failure patients (HF). Adequate risk stratification is still a major concern for HF. The prognostic indexes have been detected, but only few parameters maintain consistently high power in predicting progression of disease and mortality. Peak oxygen consumption (VO2 peak, ml kg−1 min−1) is traditionally used for risk stratification in HF, however, there is limited evidence regarding predictive value of VO2 peak in patients taking BB.Methods: Two hundred twenty nine patients, aged 49±13 years with diagnosed HF for more than 6 months due to ischemic (n=73), idiopathic dilated (n=149) and Chagas disease (n=7) underwent a cardiopulmonary exercise test (CPX). The ejection fraction was 38±10%; clinical stabil...

Effects of Telmisartan and Bisoprolol on Blood Pressure, Peripheral Haemodynamic and Lipid Profile in Statin-Treated Hypertensive Hypercholesterolaemic Patients.

High Blood Pressure & Cardiovascular Prevention — Sat, 23 May 2009 02:55:59 +0100

Page: 7DOI: 10.2165/00151642-200916010-00002Authors: Veronesi, Maddalena; Cicero, Arrigo F.G.; Prandin, Maria Grazia; Di Gregori, Valentina; Ambrosioni, Ettore; Borghi, Claudio (Source: High Blood Pressure & Cardiovascular Prevention)

Use of a nurse-led intervention to optimize beta-blockade for reducing cardiac events after major noncardiac surgery.

American Heart Journal — Wed, 01 Apr 2009 04:00:00 +0100

CONCLUSIONS: These data confirm a persistent CE rate after major noncardiac surgery despite nurse-led dose titration of bisoprolol. Cardiac events were equivalent to a UC strategy based on DbE results. PMID: 19332211 [PubMed - in process] (Source: American Heart Journal)

Bisoprolol and carvedilol in healthy dogs

Advances in Small Animal Medicine and Surgery — Wed, 01 Apr 2009 04:00:00 +0100

Chronic β1-adrenoceptor signaling occurs in a failing heart. The use of β-adrenoceptor blockers is beneficial in management of humans with heart failure. Second- and third-generation β-adrenoceptor blockers effects include improved systolic function, prevention of worsening systolic function, and reduced remodeling. Both β1-adrenoceptor-selective agents and third-generation pan-adrenoceptor blocking compounds are effective in prolonging survival in humans with chronic heart failure. There has been increased interest in the use of β-adrenoceptor blockers in management strategies for heart failure associated with myxomatous valve degeneration in dogs. (Source: Advances in Small Animal Medicine and Surgery)

Skeletal muscle proteins oxidation in chronic right heart failure in rats: Can different beta-blockers prevent it to the same degree?

International Journal of Cardiology — Tue, 17 Mar 2009 00:00:00 +0100

Conclusions: Nebivolol seems better than bisoprolol in CHF by decreasing apoptosis and cytokines induced muscle wastage, preventing fibers shift and protein oxidation. Nebivolol by stimulating NO generation may have prevented protein oxidation. It could be speculated that ROS release, pro-inflammatory cytokines production and NF-kappa-B activation may play a key role. These positive changes could produce a favorable impact on exercise capacity in man. (Source: International Journal of Cardiology)

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Nebivolol: a third-generation beta-blocker for hypertension.

Clinical Therapeutics — Sun, 01 Mar 2009 00:00:00 +0100

CONCLUSIONS: Nebivolol is a cardioselective beta-blocker that has been reported to be efficacious and well tolerated for achieving BP control in patients with hypertension. Preliminary evidence suggests a potential for reduced mortality in patients with heart failure. PMID: 19393838 [PubMed - indexed for MEDLINE] (Source: Clinical Therapeutics)

Chiral separation of beta-adrenergic blockers on CelluCoat column by HPLC.

Talanta — Wed, 11 Feb 2009 19:27:16 +0100

Authors: Ali I, Gaitonde VD, Aboul-Enein HY, Hussain A The chiral separation of 10 beta-adrenergic blockers (acebutalol, alprenolol, bufuralol, bisoprolol, celiprolol, carazolol, indenolol, metoprolol, oxprenolol and propranolol) was achieved on CelluCoat column (250mmx4.6mm, 5mum particle size). The mobile phases used were (90:10:0.2, v/v/v) and (95:5:0.2, v/v/v) combinations of n-heptane-ethanol-diethylamine, respectively. The flow rates were 0.5, 1.0 and 2.0mLmin(-1) with detection at 225nm. The capacity (k), selectivity (alpha) and resolution (R(s)) factors were 0.44-12.91, 1.12-2.19 and 1.00-9.50, respectively. The proposed supra-molecular models indicated that the chiral resolution were governed by pi-pi interactions, hydrogen bondings and steric effect. PMID: 19203609 [PubMe...

Chiral separations of some beta-adrenergic agonists and antagonists on AmyCoat column by HPLC.

Chirality — Tue, 10 Feb 2009 05:00:00 +0100

Authors: Ali I, Saleem K, Gaitonde VD, Aboul-Enein HY, Hussain I Sixteen beta-adrenergic antagonists namely acebutalol, alprenolol, atenolol, bisoprolol, bopindolol, bufurolol, carazolol, celiprolol, indenolol, metaprolol, nebivolol, oxprenolol, practolol, propranolol, tertalol, and timolol, and two beta-adrenergic agonists namely cimeterol and clenbuterol were resolved on AmyCoat (150 x 46 mm, 3 mum size of silica particle) by using (85:15:0.1, v/v/v), (90:10:0.1, v/v/v), and (95:05:0.1, v/v/v) combinations of n-heptane, ethanol, and diethylamine solvents, respectively. The flow rates used were 0.5, 1.0, 2.0, and 3.0 ml/min with detection at 225 nm. The values of capacity, separation, and resolution factors ranged from 0.38 to 19.70, 1.08-2.33, and 1.0 and 4.50, respectively. The maxi...