MedWorm: Botox

Allergan to rely less on U.S. for sales, Asia key

Reuters: Health — Fri, 03 Feb 2012 10:51:14 +0100

(Reuters) - Allergan Inc, maker of wrinkle treatment Botox, eye drops and obesity treatments, said it will rely less on the United States for revenue in coming years as its products gain wider acceptance in Asia, particularly China. (Source: Reuters: Health)

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Allergan expects strong European sales

FT.com - Drugs and Healthcare — Fri, 03 Feb 2012 04:44:16 +0100

The US maker of Botox is betting that its European business will see a lift as plastic surgeons shift away from lower cost breast implants (Source: FT.com - Drugs and Healthcare)

Medial rectus Botox injection with pterygium excision and autograft as a novel technique for management of recurrent pterygium

Clinical and Experimental Ophthalmology — Thu, 02 Feb 2012 05:00:00 +0100

Non-Specialists Expand Into Lucrative Cosmetic Surgery Procedures

NYT — Tue, 31 Jan 2012 21:10:08 +0100

With declining insurance reimbursements, more doctors are expanding their practices to include things like breast augmentation and liposuction paid for out-of-pocket by patients. (Source: NYT)

Re‐epithelialization of demucosalized stomach patch with tissue‐engineered urothelial mucosa combined with Botox A in bladder augmentation

BJU International — Tue, 31 Jan 2012 05:00:00 +0100

CONCLUSIONS• Botox A injections appear to protect the graft contraction in the re‐epithelialized stomach flaps.• The gastrocystoplasty using demucosalized patches covered with tissue‐engineered urothelial mucosa combined with an injection of Botox A could have clinical potential for use in bladder reconstruction. (Source: BJU International)

Health at Every Size Is Anti-Dieting

Psychology Today Food and Diet Center — Mon, 30 Jan 2012 23:45:31 +0100

Poretsky explains: “If you love your body, you don't need diets or lap bands or botox or weight loss drugs. If you love your body, you're less likely to accept ill treatment, discrimination, bad medical care, etc. We have huge industries like the diet, pharmaceutical, beauty, marketing industries that literally bank on our self-hatred to sell products.” read more (Source: Psychology Today Food and Diet Center)

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UK plastic surgery statistics: breasts up, stomachs in

Guardian Unlimited Science — Mon, 30 Jan 2012 08:00:00 +0100

UK plastic surgery is on the increase, despite the recession. Find out which procedures are going up - and which are down• Get the dataPlastic surgery is big business in the UK - and despite the recession, it's a growing one.Breast augmentations are still by far the most popular cosmetic surgery procedure for women and have risen year on year - although these figures take no account of the breast implant scandal, which recently led plastic surgeons to call for a ban on advertising it.Plastic surgery statistics in the UK show a record number of male 'tummy tuck' operations as the rise in demand outstrips that for all other procedures - including women's breast enlargement.Figures published by the British Association of Aesthetic Plastic Surgeons (BAAPs) - that really is its acronym - show...

Botox for Treating Migraines

Sound Medicine — Sun, 29 Jan 2012 05:00:00 +0100

So much attention has been focused on the cosmetic uses of botulinum toxin, usually known by its trade name, Botox, that it's easy to forget about the drug's serious medical uses. For example, the FDA recently approved Botox for preventing chronic migraines. Sound Medicine's David Crabb, MD, sat down with Indiana University neurologist Jay Bhatt, MD, to learn how it works. Dr. Bhatt is.... (Source: Sound Medicine)

OnabotulinumtoxinA in Pediatric Chronic Daily Headache

Current Neurology and Neuroscience Reports — Tue, 24 Jan 2012 12:27:04 +0100

This study showed a major change in the frequency of the headache with a statistical difference in the improvement of headache days per month. There was a 30-point drop in the pediatric disability scoring between first injection and follow-up injection with a change from severe disability to moderate disability. Content Type Journal ArticleCategory Headache (I Garza, Section Editor)Pages 1-4DOI 10.1007/s11910-012-0251-1Authors Marielle Kabbouche, Division of Neurology, Cincinnati Children’s Hospital Medical Center, Headache Center, MLC #2015, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USAHope O’Brien, Division of Neurology, Cincinnati Children’s Hospital Medical Center, Headache Center, MLC #2015, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USAAndrew D. Hershey, Divis...

Botulinum toxin in the treatment of facial synkinesis and hyperkinesis

The Laryngoscope — Tue, 17 Jan 2012 05:00:00 +0100

Conclusions:This work stresses the importance of considering synkinesis and hyperkinesis separately because they are different conditions. These two symptoms showed improvement after botulinum toxin treatment, but only hyperkinesis showed a positive correlation when objective and subjective evaluations were performed. This treatment is effective in the management of facial synkinesis and hyperkinesis due to facial palsy, thus improving quality of life. It is a safe, minimally invasive treatment that can be repeated. (Source: The Laryngoscope)

Botulinum toxin in the treatment of facial synkinesis and hyperkinesis.

Herpes — Tue, 17 Jan 2012 05:00:00 +0100

CONCLUSIONS: This work stresses the importance of considering synkinesis and hyperkinesis separately because they are different conditions. These two symptoms showed improvement after botulinum toxin treatment, but only hyperkinesis showed a positive correlation when objective and subjective evaluations were performed. This treatment is effective in the management of facial synkinesis and hyperkinesis due to facial palsy, thus improving quality of life. It is a safe, minimally invasive treatment that can be repeated. PMID: 22252570 [PubMed - as supplied by publisher] (Source: Herpes)

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Pass notes No 3,108: Crow's feet

Guardian Unlimited Science — Mon, 16 Jan 2012 20:00:00 +0100

Why have they vanished from celebrities' faces?Age: That would be telling.Appearance: Like something you'd find at the end of a crow's ankle.What about them? They're disappearing.From where? Restaurant menus? No, from people's faces.Don't. I have a phobia about birds being near me. We're not talking about actual crow's feet, but those tiny wrinkles radiating outward from the eyes that denote experience, character and a life spent in laughter.And being old. Yes, that too, unfortunately.From whose faces are these wrinkles disappearing, pray tell? Madonna's, for one. Her eerily smooth visage cropped up both on The Graham Norton Show and the Golden Globes at the weekend.I'm sure that's down to a good moisturiser and her famously placid temperament. And Carla Bruni recently returned to public l...

One botulinum toxin slightly better than another for crow's feet

Modern Medicine — Fri, 13 Jan 2012 05:00:00 +0100

NEW YORK (Reuters Health) - Two botulinum toxins improved crow's feet as early as day two in a new side-by-side comparison. But abobotulinumtoxinA (Dysport) smoothed the lines more noticeably than onabotulinumtoxinA (Botox Cosmetic), according to researchers. (Source: Modern Medicine)

New study: Botox affects 'distant' muscles, too

Modern Medicine — Thu, 12 Jan 2012 05:00:00 +0100

Results of a new study suggest that Botox (onabotulinumtoxinA, Allergan) has previously unsuspected and long-lasting systemic effects on muscles other than the ones into which it’s injected. (Source: Modern Medicine)

[Botulinum toxin A: Analgesic treatment for temporomandibular joint disorders.]

Revue de Stomatologie et de Chirurgie Maxillo-Faciale — Tue, 10 Jan 2012 05:00:00 +0100

DISCUSSION: Botulinum toxin A significantly decreases pain and improves movements of patients presenting with temporomandibular joint disorders. The effects are prolonged three months after the injection. PMID: 22240328 [PubMed - as supplied by publisher] (Source: Revue de Stomatologie et de Chirurgie Maxillo-Faciale)

Cosmetic procedures compared for safety

Health News - UPI.com — Tue, 10 Jan 2012 01:54:31 +0100

CHICAGO, Jan. 9 (UPI) -- A U.S. review of studies identified Botox, liposuction and lasers as cosmetic procedures considered safe and effective, researchers say. (Source: Health News - UPI.com)

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Botox Has Effects On Unintended Muscles

Health News from Medical News Today — Fri, 06 Jan 2012 08:00:00 +0100

According to a study in the January issue of Anesthesia & Analgesia, the official journal of the International Anesthesia Research Society (IARS), Botox (Botulinum neurotoxin type A) has previously unsuspected 'systemic' effects on muscles other than the ones it's injected into... (Source: Health News from Medical News Today)

Botulinum toxin type A for the treatment of lower urinary tract disorders

International Journal of Urology — Fri, 06 Jan 2012 05:00:00 +0100

AbstractMany papers report the clinical success of botulinum toxin A as a method of management of various bladder dysfunctions. The rationale was that botulinum toxin A was able to block the presynaptic release of acetylcholine from the parasympathetic efferent nerve. The efficacy might result not only from an inhibitory effect on detrusor muscle, but also some effects might be mediated by altering the afferent nerve input. This systematic literature review discusses the efficacy and safety of botulinum toxin A therapy for idiopathic detrusor overactivity, neurogenic detrusor overactivity, interstitial cystitis/painful bladder syndrome and benign prostatic hyperplasia. The information was gathered from a PubMed literature research for abstracts from recent urological meetings. Inject...

Botox Affects Other Muscles, As Well As The Intended Ones

Health News from Medical News Today — Thu, 05 Jan 2012 17:00:00 +0100

According to an investigation published in the January issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS), researchers have discovered that injecting Botox (botulinum neurotoxin type A) affects muscles other than those it's injected into. The study, led by Dr Christiane G. Frick of Massachusetts General Hospital, Boston, demonstrates that rats injected with Botox display lasting effects on muscles after injection, even in muscles far from where Botox was injected... (Source: Health News from Medical News Today)

Expression of apoptosis-regulating genes in the rat prostate following botulinum toxin type A injection

BMC Urology - Latest articles — Wed, 04 Jan 2012 05:00:00 +0100

Conclusions: These results support the hypothesis that OnabotA activates apoptotic pathways in the rat prostate through a mechanism that involves sympathetic outflow impairment. (Source: BMC Urology - Latest articles)

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Comparison of two Different Formulations of Botulinum Toxin a for the Treatment of Blepharospasm and Hemifacial Spasm.

Turkish Neurosurgery — Thu, 29 Dec 2011 18:00:03 +0100

CONCLUSION: The two preparations were both simple and effective for the patients with blepharospasm and hemifacial spasm. PMID: 22194126 [PubMed - in process] (Source: Turkish Neurosurgery)

Botulinum Toxin: Clinical Techniques, Applications, and Complications

Facial Plastic Surgery — Wed, 28 Dec 2011 05:00:00 +0100

This article outlines practice routines, clinical techniques, applications, and complications of botulinum toxin type A treatment of mimetic facial and neck muscles. Detailed descriptions are provided for each clinical indication that maximize the treatment of the intended muscle groups while minimizing potential complications.[...]© Thieme Medical PublishersArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Facial Plastic Surgery)

[Botulinum toxin type A contribution in the treatment of Raynaud's phenomenon due to systemic sclerosis.]

Annales de Chirurgie Plastique et Esthetique — Mon, 26 Dec 2011 05:00:00 +0100

CONCLUSION: BTX A appears to improve significantly Raynaud's phenomenon symptomatology in patients with systemic sclerosis despite the component of arterial sclerosis. PMID: 22204894 [PubMed - as supplied by publisher] (Source: Annales de Chirurgie Plastique et Esthetique)

Dysport tops Botox in crow's feet study

Modern Medicine — Sun, 25 Dec 2011 12:07:27 +0100

A new study suggests that abobotulinumtoxinA (Dysport, Medicis) may be more effective in treating orbital rhytids — crow’s feet — than onabotulinumtoxinA (Botox, Allergan). (Source: Modern Medicine)

Botox Shows Lasting Effects On Distant Muscles

Health News from Medical News Today — Fri, 23 Dec 2011 09:00:00 +0100

Botulinum neurotoxin type A better known as Botox has previously unsuspected 'systemic' effects on muscles other than the ones it's injected into, reports a study in the January issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS). Experiments in rats show that Botox has lasting effects on muscles after injection even muscles distant from the injection site. In addition, Botox seems to have "unique" effects on muscle responses to a widely used muscle relaxant, which could affect patient monitoring during surgery or mechanical ventilation... (Source: Health News from Medical News Today)

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Dysport Bests Botox in Crow's Feet Study (CME/CE)

MedPage Today State Required CME — Tue, 20 Dec 2011 14:43:13 +0100

(MedPage Today) -- Abobotulinumtoxin A showed greater improvement in crow's feet than onabotulinumtoxinA at days four and six after injection according to the results of a split-face, double-blind study. (Source: MedPage Today State Required CME)

Neurotherapeutics to inhibit exocytosis from sensory neurons for the control of chronic pain.

Current Opinion in Pharmacology — Mon, 19 Dec 2011 05:00:00 +0100

Authors: Dolly JO, O'Connell MA Abstract There is a pressing unmet need for long-acting and effective therapeutics to alleviate symptoms of the varied forms of chronic pain. As many sufferers do not respond satisfactorily to non-addictive anti-nociceptives, a new treatment has emerged using inhibitors for the release of pain mediators from peripheral sensory nerves to give prolonged benefit. This strategy relies on proteolytically inactivating intra-neuronal SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptors) proteins which are essential for regulated exocytosis of transmitters, peptides and other pain signalling molecules. Success has been achieved with botulinum neurotoxin A (BoNT/A) which targets neuronal acceptors via its heavy chain, becomes endocyto...

Botulinum toxin A for the treatment of neurogenic detrusor overactivity in multiple sclerosis patients

International Braz J Urol — Wed, 14 Dec 2011 02:22:41 +0100

CONCLUSIONS: Despite that a full success was obtained in 46% of the cases, BTX-A injection therapy failed to treat refractory NDO in 23% of patients suffering from MS. Duration of the disease was a predictive factor for an inefficient treatment. The injection therapy should be considered as soon as oral anticholinergic drugs fail to reduce NDO. (Source: International Braz J Urol)

My Botox Birthday

Psychology Today Sex Center — Fri, 09 Dec 2011 15:52:27 +0100

I am coming out. I have turned fifty, and I love Botox its kissing cousin Dysport. Both Botox and Dysport do the same thing—they get rid of what I personally find so annoying, those deep creases in my forehead and between my brows that seem to have appeared over night on that landmark birthday. Primary Topic: Aging read more (Source: Psychology Today Sex Center)

Suit claims Allergan encouraged unsafe use of Botox

Modern Medicine — Thu, 08 Dec 2011 05:00:00 +0100

A Las Vegas plastic surgeon is suing Botox-maker Allergan, claiming the Irvine-based company sold the drug in large vials and encouraged physicians to unsafely reuse them, the Los Angeles Times reports. (Source: Modern Medicine)

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First Person: Sweat and Tears — First Person

NYT Health — Wed, 07 Dec 2011 21:59:50 +0100

A treatment to reduce excessive underarm perspiration leaves one man wondering if it was worth it. (Source: NYT Health)

Suit claims Allergan encouraged unsafe use of Botox

Modern Medicine — Wed, 07 Dec 2011 05:00:00 +0100

Nanotechnology's future bright, but knowledge, research still lacking

Modern Medicine — Thu, 01 Dec 2011 05:00:00 +0100

With potential applications that range from sunscreen products to chemotherapy drugs, from topically applied botulinum toxin type A to nanoparticle vaccines, the field of nanotechnology is poised to forever change the practice of dermatology. But according to a recent survey, the fairly new science needs some good, old-fashioned awareness-building among practitioners. (Source: Modern Medicine)

Randomized controlled study of the efficacy of the injection of botulinum toxin type A versus corticosteroids in chronic plantar fasciitis: results at one and six months.

Clinical Rehabilitation — Thu, 01 Dec 2011 05:00:00 +0100

Conclusion: Botulinum toxin type A should be considered for the treatment of chronic plantar fasciitis in view of the improvement found at one month, and particularly at six months, when this treatment clearly has better results than corticosteroid injections. Further studies with larger samples are necessary to confirm these results. PMID: 22144721 [PubMed - as supplied by publisher] (Source: Clinical Rehabilitation)

BOTOX COSMETIC (Onabotulinumtoxina) Injection, Powder, Lyophilized, For Solution [Allergan, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 29 Nov 2011 05:00:00 +0100

Updated Date: Nov 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Substantial savings with Dysport versus Botox

PharmacoEconomics and Outcomes News — Tue, 29 Nov 2011 03:49:39 +0100

(Source: PharmacoEconomics and Outcomes News)

BOTOX (Onabotulinumtoxina) Injection, Powder, Lyophilized, For Solution [Allergan, Inc. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 23 Nov 2011 05:00:00 +0100

Updated Date: Nov 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

SNARE-Wedging Polyphenols as Small Molecular Botox

Planta Medica — Tue, 22 Nov 2011 05:00:00 +0100

Planta MedDOI: 10.1055/s-0031-1280385AbstractMost cosmetic and therapeutic applications of Clostridium botulinum neurotoxin (BoNT) are related to muscle paralysis caused by the blocking of neurotransmitter release at the neuromuscular junction. BoNT specifically cleaves SNARE proteins at the nerve terminal and impairs neuroexocytosis. Recently, we have shown that several polyphenols inhibit neurotransmitter release from neuronal PC12 cells by interfering with SNARE complex formation. Based on our previous result, we report here that myricetin, delphinidin, and cyanidin indeed paralyze muscle by inhibiting acetylcholine release at the neuromuscular junction. While the effect of myricetin on muscle paralysis was modest compared to BoNT/A, myricetin exhibited a shorter response time than BoNT...

Botulinum toxin type A in the management of a neuropathic foot ulcer

Clinical And Experimental Dermatology — Sat, 19 Nov 2011 22:24:48 +0100

(Source: Clinical And Experimental Dermatology)

Atrophy of Corrugator Supercilii Muscle in a Patient Induced by the Onabotulinum Toxin Injection

Headache: The Journal of Head and Face Pain — Tue, 15 Nov 2011 05:00:00 +0100

We report a case of a 29‐year‐old woman who developed temporary and reversible atrophy of corrugator supercilii muscle after onabotulinum toxin (Botox, Allergan, Irvine, CA, USA) injection. To our best knowledge this has not been described in the literature before. (Source: Headache: The Journal of Head and Face Pain)

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Atrophy of Corrugator Supercilii Muscle in a Patient Induced by the Onabotulinum Toxin Injection.

Headache — Tue, 15 Nov 2011 05:00:00 +0100

We report a case of a 29-year-old woman who developed temporary and reversible atrophy of corrugator supercilii muscle after onabotulinum toxin (Botox, Allergan, Irvine, CA, USA) injection. To our best knowledge this has not been described in the literature before. PMID: 22085341 [PubMed - as supplied by publisher] (Source: Headache)

Health Canada Approves BOTOX® As Prophylactic Treatment For Chronic Migraine

Pharmaceutical Online News — Tue, 15 Nov 2011 04:50:00 +0100

Chronic Migraine sufferers in Canada now have an option to prevent the onset of headaches that occur over 15 days a month and leave patients debilitated. (Source: Pharmaceutical Online News)

Commentary Re: Botox Article by Berger & Knoll IPH 19(5):243–244 on “The efficacy of botulinum toxin type A in managing chronic musculoskeletal pain: a systematic review and meta analysis”

Inflammopharmacology — Mon, 14 Nov 2011 16:53:53 +0100

Commentary Re: Botox Article by Berger & Knoll IPH 19(5):243–244 on “The efficacy of botulinum toxin type A in managing chronic musculoskeletal pain: a systematic review and meta analysis” Content Type Journal ArticleCategory Short CommunicationPages 1-1DOI 10.1007/s10787-011-0100-xAuthors Tony Zhang, Schulich School of Medicine, University of Western Ontario, London, ON, CanadaAleem Adatia, Schulich School of Medicine, University of Western Ontario, London, ON, CanadaWasifa Zarin, Faculty of Health Sciences, McMaster University, Hamilton, ON, CanadaMisha Moitri, Faculty of Health Sciences, McMaster University, Hamilton, ON, CanadaAbi Vijenthira, Faculty of Health Sciences, McMaster University, Hamilton, ON, CanadaRong Chu, Department of Epidemiology and Biostatistics, McMaster Un...

Botulinum Toxin Type A: New Information on an Old MedicineBotulinum Toxin Type A: New Information on an Old Medicine

Medscape Today Headlines — Thu, 10 Nov 2011 11:20:44 +0100

There are currently three formulations of botulinum toxin type A available for dermatologic use, each with unique pharmacologic and pharmacokinetic properties. What do you need to know? Skin Therapy Letter (Source: Medscape Today Headlines)

Treatment of pectoralis major flap myospasms with botulinum toxin type A in head and neck reconstruction

Journal of Plastic, Reconstructive and Aesthetic Surgery — Thu, 10 Nov 2011 05:00:00 +0100

Conclusion: BTX-A infiltration is an effective non-invasive procedure that significantly reduces the PM muscular contraction in head and neck reconstruction. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

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Combined therapeutic application of botulinum toxin type A, low-frequency rTMS, and intensive occupational therapy for post-stroke spastic upper limb hemiparesis.

European Journal of Physical and Rehabilitation Medicine — Wed, 09 Nov 2011 05:00:00 +0100

Conclusion. The protocol is safe and feasible, although further larger studies are needed to confirm its efficacy. Clinical Rehabilitation Impact. The protocol is a potentially useful neurorehabilitative approach for this patient population. PMID: 22071503 [PubMed - as supplied by publisher] (Source: European Journal of Physical and Rehabilitation Medicine)

Review Available on BoNT-A for Use in MS

American Academy of Neurology — Fri, 04 Nov 2011 17:55:00 +0100

The Multiple Sclerosis Emerging Therapies Collaborative has published information sheets on the drug botulinum toxin type A (BoNT-A, also known as Botox) for use in multiple sclerosis. (Source: American Academy of Neurology)

Rationale and design of a prospective study: Cervical Dystonia Patient Registry for Observation of OnaBotulinumtoxinA Efficacy (CD PROBE)

BMC Neurology — Fri, 04 Nov 2011 04:00:00 +0100

DiscussionThis ongoing registry includes 609 subjects with the following baseline data: 75.9% female, 93.6% Caucasian, mean age 57.6 +/- 14.3, age at symptom onset 48.3 +/- 16.2, and time to diagnosis 5.4 +/- 8.6 years, with an additional 1.0 +/- 3.5 years before treatment. Of those employed at the time of diagnosis, 36.6% stopped working as a result of CD. CD PROBE, the largest clinical registry of CD treatment, will provide useful data on current treatment practices with onabotulinumtoxinA, potentially leading to refinements for optimization of outcomes.Trial registration: NCT00836017 (Source: BMC Neurology)

Application of Botulinum toxin Type A: An arsenal in dentistry

Table of Contents : Indian Journal of Dental Research : 2006 - 17(3) — Thu, 03 Nov 2011 04:00:00 +0100

Lakshmana B Rao, Rajashekar Sangur, S PradeepIndian Journal of Dental Research 2011 22(3):440-445An extremely effective way of preventing damage to and enhancing treatment of dental hard tissues and restorations would be to ''de-programme'' the muscles responsible for excessive destructive forces and other gnathological-related diseases. The new paradigm is the intramuscular injection of Botulinum toxin type A (BOTOX) into the affected muscles. It is a natural protein produced by anaerobic bacterium, Clostridium botulinum. The toxin inhibits the release of acetylcholine (ACH), a neurotransmitter responsible for the activation of muscle contraction and glandular secretion, and its administration results in reduction of tone in the injected muscle. There are seven...

Influence of botulinum toxin on rabbit jaw muscle activity and anatomy

Muscle and Nerve — Wed, 02 Nov 2011 04:00:00 +0100

Discussion:Silencing the activity in the masseter not only causes changes in the fibers of the injected muscle but also leads to changes in other jaw muscles. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve)

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BOTOX (Onabotulinumtoxina) Injection, Powder, Lyophilized, For Solution [Allergan, Inc. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 27 Oct 2011 05:00:00 +0100

Updated Date: Oct 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BOTOX COSMETIC (Onabotulinumtoxina) Injection, Powder, Lyophilized, For Solution [Allergan, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 27 Oct 2011 05:00:00 +0100

Updated Date: Oct 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Botox sales grow despite Europe's wrinkles

FT.com - Drugs and Healthcare — Wed, 26 Oct 2011 19:20:49 +0100

Allergan chief 'favourably surprised' by product's success in spite of the economic woes on the continent caused by the sovereign debt crisis (Source: FT.com - Drugs and Healthcare)

Botox Treats Tremor in Multiple SclerosisBotox Treats Tremor in Multiple Sclerosis

Medscape Today Headlines — Thu, 20 Oct 2011 23:00:33 +0100

A new study shows that botulinum toxin injections provided relief from tremor in patients with MS, with few adverse effects. Medscape Medical News (Source: Medscape Today Headlines)

ECTRIMS: Botox Cuts MS-Related Arm Tremors (CME/CE)

MedPage Today Meeting Coverage — Thu, 20 Oct 2011 21:54:49 +0100

AMSTERDAM (MedPage Today) -- Injections of botulinum toxin A (Botox) were a significant help to multiple sclerosis patients whose disease causes arm tremors, according to a small study reported here. (Source: MedPage Today Meeting Coverage)

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Botox cuts MS-related arm tremors [ECTRIMS]

Multiple Sclerosis Trust — Wed, 19 Oct 2011 23:00:00 +0100

Injections of botulinum toxin A (Botox) were a significant help to multiple sclerosis patients whose disease causes arm tremors, according to a small study reported here. (Source: Multiple Sclerosis Trust)

Botox for the prophylaxis of headaches in chronic migraine

Prescriber — Wed, 19 Oct 2011 04:00:00 +0100

AbstractBotulinum toxin type A (Botox) has been licensed for the prophylaxis of headaches in chronic migraine. In our New products review Steve Chaplin presents the clinical data relating to its efficacy and adverse events and Professor Anne MacGregor discusses its place in the treatment of migraine. Copyright © 2011 Wiley Interface Ltd (Source: Prescriber)

Botox in the battle against wrinkles

Monsters and Critics Health News — Mon, 17 Oct 2011 03:06:03 +0100

(Source: Monsters and Critics Health News)

Comparison of the spread of three botulinum toxin type A preparations

Archives of Dermatological Research — Sat, 15 Oct 2011 05:48:06 +0100

Abstract Botulinum toxins are frequently used in esthetics to improve the appearance of facial wrinkles. In this setting, precise localization of the neurotoxin is required to produce the desired clinical effects. Unwanted effects can occur if the neurotoxin diffuses into untargeted muscle. Therefore, a neurotoxin with low and predictable spread would be preferable for esthetic applications. The aim of this study was to investigate the spread of three approved botulinum toxin type A preparations, with and without complexing proteins, by measuring and comparing the size of the anhidrotic halos they produced following injection of equivalent doses in an identical volume into the forehead of patients. The results showed that incobotulinumtoxinA and onabotulinumtoxinA displaye...

Effect of botulinum toxin type A and modified constraint-induced movement therapy on motor function of upper limb in children with obstetrical brachial plexus palsy

Child's Nervous System — Fri, 14 Oct 2011 06:09:38 +0100

Content Type Journal ArticleCategory Case ReportPages 1-6DOI 10.1007/s00381-011-1609-4Authors Andrea Santamato, Department of Physical Medicine and Rehabilitation—“OORR Hospital”, University of Foggia, Foggia, ItalyFrancesco Panza, Geriatric Unit and Gerontology—Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, ItalyMaurizio Ranieri, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, ItalyPietro Fiore, Department of Physical Medicine and Rehabilitation—“OORR Hospital”, University of Foggia, Foggia, Italy Journal Child's Nervous SystemOnline ISSN 1433-0350Print ISSN 0256-7040 (Source: Child's Nervous System)

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NETAG issues recommendation on Botox® for chronic migraine

NeLM - Drug Specific Reviews — Fri, 14 Oct 2011 04:00:00 +0100

Source: NETAG Area: Evidence > Drug Specific Reviews The NHS North East Treatment Advisory Group (NETAG) has issued a recommendation and associated appraisal report on the use of botulinum toxin type A (Botox®) for the treatment of chronic migraine. The Group did not recommend its use as it was concerned about the clinical efficacy of treatment and important uncertainties remained regarding interpretation of cost effectiveness. (Source: NeLM - Drug Specific Reviews)

BOTOX 50 Units- Revised SPC

NeLM - SPC Changes — Thu, 13 Oct 2011 04:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes There have been significant updates to several sections of the SPC, the following sections have all been updated: Change to section 4.1 - Therapeutic indications Change to section 4.2 - Posology and method of administration Change to section 4.4 - Special warnings and precautions for Use Change to section 4.5 - Interaction with other medicinal products and other forms of interaction Change to section 4.8 - Undesirable Effects Change to section 4.9 - Overdose Change to section 5.1 - Pharmacodynamic Properties Change to section 10 - Date of revision of the text Please refer to the SPC link below for full information on all changes (Source: NeLM - SPC Changes)

Scottish Medicines Consortium accepts Xeomin®) (botulinum toxin type A) for use in NHS Scotland for post-stroke spasticity of upper limb

NeLM - Drug Specific Reviews — Tue, 11 Oct 2011 04:00:00 +0100

Source: Scottish Medicines Consortium (SMC) Area: Evidence > Drug Specific Reviews The Scottish Medicines Consortium (SMC) has accepted for use within NHS Scotland Xeomin®) (botulinum toxin type A) as a treatment for adult patients with post-stroke spasticity of the upper limb presenting with flexed wrist and clenched fist. The SMC notes that in patients for whom botulinum toxin, type A is an appropriate choice of therapy, this offers an alternative formulation to the comparator product containing conventional botulinum toxin, type A complex. (Source: NeLM - Drug Specific Reviews)

OnabotulinumtoxinA improves quality of life and reduces impact of chronic migraine

Neurology — Mon, 10 Oct 2011 04:00:00 +0100

Conclusions: Treatment of CM with onabotulinumtoxinA is associated with significant and clinically meaningful reductions in headache impact and improvements in HRQoL. Classification of evidence: This study provides Class 1A evidence that onabotulinumtoxinA treatment reduces headache impact and improves HRQoL. (Source: Neurology)

Botox feels right for post-stroke spasticity in Scotland

PharmacoEconomics and Outcomes News — Mon, 10 Oct 2011 03:06:48 +0100

(Source: PharmacoEconomics and Outcomes News)

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[Value of nerve growth factor levels in overactive bladder syndrome : Alterations after botulinum toxin therapy.]

Der Urologe. Ausg. A — Sat, 08 Oct 2011 04:00:00 +0100

CONCLUSION: NGF appears to play a decisive role in OAB. Its use as a biomarker in both the diagnostics and follow-up after therapy seems promising. To what extent sNGF can be useful as a biomarker or in therapy monitoring needs to be examined prospectively in a larger population. PMID: 21979907 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)

Is high dose botulinum toxin in combination with fissurectomy safe and effective in the management of chronic anal fissure?

International Journal of Surgery — Thu, 06 Oct 2011 22:52:32 +0100

Aims: To identify the efficacy and morbidity of using 100 units of Botulinum Toxin (BoTox) and fissurectomy in the management of chronic anal fissure (CAF). Methods: All patients with CAF who underwent fissurectomy and BoTox injection, by a single surgeon over a period of thirty-two months were evaluated. Data collected included: demographics, duration of symptoms, location of fissure, symptomatic improvement, fissure healing, continence and complications. Patients were reviewed at three months following surgery or until complete healing. (Source: International Journal of Surgery)

Intravesical botox for overactive bladder

International Journal of Surgery — Thu, 06 Oct 2011 22:52:31 +0100

Aim: Overactive bladder (OAB) affects over 16% of those above 40 years. Intravesical Botox has been shown to reduce void frequency, incontinence episodes and improve quality of life in patients with OAB. Known complications include urinary retention and need for intermittent self catheterisation (ISC). (Source: International Journal of Surgery)

DYSPORT (Botulinum Toxin Type A) Injection, Powder, Lyophilized, For Solution [Medicis Pharmaceutical Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 06 Oct 2011 05:00:00 +0100

Updated Date: Oct 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Women, Beauty and Botulism

Psychology Today Depression Center — Wed, 05 Oct 2011 13:44:41 +0100

Women have “bad hair days,” we have “nothing to wear,” our shoes hurt and we “feel fat.” Primary Topic: Eating Disorders read more (Source: Psychology Today Depression Center)

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Latisse: Christina Hendricks' 'Botox for eyelashes' - made from a glaucoma medicine

the Mail online | Health — Mon, 03 Oct 2011 07:42:44 +0100

The Latisse procedure involves applying a lotion that encourages lashes to grow and thicken - and it is already a hit in the U.S., where it is used by the Mad Men star. (Source: the Mail online | Health)

Frey's syndrome associated with bilateral trifid mandibular condyle: a rare case report

International Journal of Oral and Maxillofacial Surgery — Sat, 01 Oct 2011 04:00:00 +0100

The occurrence of hyperesthesia, flushing and sweating on cheek and pre-auricular area are signs and symptoms of Frey's syndrome. This syndrome was firstly described in 1757 but only in 1923 Lucie Frey, a Frenchwoman medical, described this occurrence after neural damage. The incidence of this syndrome is rare and can be associated to direct or indirect damage of greater auricular nerve and/or auriculotemporal nerve; the spontaneous occurrence is extremely rare and can be associated with normality variation. Other rare case is the bilateral trifid mandibular condyle, usually this modification of the normal anatomy can be associated with fracture, but the association with embryological changes is rare. The aim of this case report is to show a rare case of spontaneous Frey's syndrome associa...

DYSPORT (Botulinum Toxin Type A) Injection, Powder, Lyophilized, For Solution [Medicis Pharmaceutical Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 30 Sep 2011 05:00:00 +0100

Updated Date: Sep 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Botox prevents headaches long-term in patients with chronic migraine

Modern Medicine — Thu, 29 Sep 2011 04:00:00 +0100

(Source: Modern Medicine)

The effect of surgical and chemical denervation on ischaemia/reperfusion injury of skeletal muscle

Journal of Plastic, Reconstructive and Aesthetic Surgery — Mon, 26 Sep 2011 04:00:00 +0100

Conclusion: Both surgical and chemical denervation applied before muscle transfer increased muscle ischaemia tolerance. With similar experimental outcomes, denervation with BoNT-A can be preferred to surgical denervation because of its abundant clinical availability and it can be applied without any secondary surgery. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

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Enduring efficacy of Botulinum toxin type A injection for refractory anterior knee pain.

Disability and Rehabilitation — Thu, 22 Sep 2011 04:00:00 +0100

Conclusions: A single BoNT-A treatment to VL led initially to improved function and relief of knee-related symptoms in 57 of 65 individuals. Improvements were sustained at follow-up, with an average benefit of 34 months (SD 25) post-injection, in 44 of 57 cases. [Box: see text]. PMID: 21936736 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)

Needle-Free Wrinkle Treatment Works Like Botox

WebMD Health — Wed, 21 Sep 2011 23:53:01 +0100

Wrinkle relief for those whose fear of needles outweighs their vanity may be on the horizon. (Source: WebMD Health)

Anti-Wrinkle Gel Might Work Like Botox Without Needles

The Doctors Lounge - Dermatology — Wed, 21 Sep 2011 14:00:00 +0100

Preliminary study suggests it reduces 'crow's feet,' but more research is needed (Source: The Doctors Lounge - Dermatology)

My new-age search for eternal youth

Daily Express - Health — Mon, 19 Sep 2011 05:37:55 +0100

Fed up with anti-wrinkle creams and unwilling to try Botox, JINI REDDY enrolled on a mystical anti-ageing course... (Source: Daily Express - Health)

Predictors of Long-term Outcome After Laparoscopic Esophagomyotomy and Dor Fundoplication for Achalasia [Paper]

Archives of Surgery — Mon, 19 Sep 2011 04:00:00 +0100

Conclusions Long-term outcomes after laparoscopic esophagomyotomy were excellent across a wide spectrum of disease severity and presentations. Previous treatments, such as balloon dilation or botulinum toxin (Botox) injection, did not portend worse outcomes. When the myotomy was extended 2 cm onto the stomach and a Dor fundoplication was performed, severe heartburn was rare. (Source: Archives of Surgery)

Migraines, MS symptoms and baldness - the other uses for Botox

Multiple Sclerosis Trust — Wed, 14 Sep 2011 23:00:00 +0100

Botox was once the preserve of the rich and famous - but only half of the treatments carried out every year are done to combat wrinkles. (Source: Multiple Sclerosis Trust)

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BOTOX (Onabotulinumtoxina) Injection, Powder, Lyophilized, For Solution [Allergan, Inc. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 13 Sep 2011 05:00:00 +0100

Updated Date: Sep 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BOTOX COSMETIC (Onabotulinumtoxina) Injection, Powder, Lyophilized, For Solution [Allergan, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 13 Sep 2011 05:00:00 +0100

Updated Date: Sep 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

US sales of Botox continue to increase

FT.com - Drugs and Healthcare — Mon, 12 Sep 2011 22:25:29 +0100

Wrinkle-erasing drug up 91% over the year as ageing US citizens increasingly turn to the medicine to preserve their youthful appearances (Source: FT.com - Drugs and Healthcare)

MedInformatix' practice management and EMRs Simplifies Texas dermatology practice's operations

Healthcare IT News Press Releases — Fri, 09 Sep 2011 14:02:22 +0100

There often comes a time when IT's forward march brings a medical practice to a crossroads, a fork in the road where both directions lead to the same destination though not equally efficiently or cost effectively. Such was the case for Flower Mound Dermatology, an 11-employee suburban Dallas practice whose administrators seven years ago recognized the importance of adding Electronic Medical Records (EMR) capabilities to its existing UNIX-based Practice Management (PM) system. read more (Source: Healthcare IT News Press Releases)

The use of botulinum toxin in benign prostatic hyperplasia

Neurourology and Urodynamics — Thu, 08 Sep 2011 04:00:00 +0100

In conclusion, BoNT/A alleviates lower urinary tract symptoms due to HBP, but different studies present considerable variations regarding the dose administered, inclusion criteria and follow‐up time, as well as poorly defined retreatment, losses to follow up and, above all, a high degree of variability in the communication of results (with large standard deviations). In consequence, further clinical trials are needed. © 2011 Wiley‐Liss, Inc. (Source: Neurourology and Urodynamics)

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FDA approves onabotulinumtoxinA for incontinence in adults with neurologic conditions

Modern Medicine — Wed, 07 Sep 2011 13:12:45 +0100

The FDA recently approved onabotulinumtoxinA (Botox) injection for the treatment of urinary incontinence due to detrusor overactivity associated with a neurologic condition (eg, spinal cord injury, multiple sclerosis) in adults who have an inadequate response to or are intolerant of an anticholinergic medication. (Source: Modern Medicine)

Botox fixed my wonky walk: Why doctors are using those cosmetic jabs to relieve painful muscular spasms

the Mail online | Health — Tue, 06 Sep 2011 00:16:53 +0100

These injections don't just make wrinkles vanish, they can weaken overactive muscles and reduce the spasms. (Source: the Mail online | Health)

Manually guided botulinum toxin type A submandibular injections for the treatment of sialorrhea in tube-fed patients with advanced amyotrophic lateral sclerosis.

American Journal of Health-System Pharmacy : AJHP — Tue, 06 Sep 2011 00:01:03 +0100

Authors: Rodriguez-Murphy E, Marti-Bonmati E, Camps-Seguí E, Bagán JV PMID: 21880878 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Botox Works Regardless of Medication History

Clinical Neurology News — Thu, 01 Sep 2011 04:00:00 +0100

Major Finding: A total 45% of 575 first-line treatment-naive chronic migraine sufferers significantly responded to onabotulinumtoxinA treatment vs. 50% of 809 others with no such medication history. (Source: Clinical Neurology News)

Botox(®) to reduce drooling in a paediatric population with neurological impairments: a Phase I study.

International Journal of Language and Communication Disorders — Thu, 01 Sep 2011 04:00:00 +0100

Conclusions & Implications: In the clinical setting of the Drooling Treatment Project, the results indicated that the context in which drooling occurs is an important factor and suggested the value of considering the situational context when making drooling judgments. Further, there was a difference in the pattern of response between the children with cerebral palsy and those with operculum syndrome, suggesting that aetiology may be involved in the response to Botox®. PMID: 21899672 [PubMed - in process] (Source: International Journal of Language and Communication Disorders)

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Digest

Progress in Neurology and Psychiatry — Thu, 01 Sep 2011 04:00:00 +0100

AbstractNewsNICE guideline on ADHDConsultation on the NICE guideline on ADHD (CG72) has now ended. The scheduled review will consider new evidence on diagnosis, management and the organisation of care emerging since the guideline was published in 2008. New clinical trials confirm current recommendations for the treatment of children, NICE says, and support the use of methylphenidate as firstline therapy in adults followed by atomoxetine or dexamfetamine for patients who do not respond to or who are intolerant of six weeks' treatment with methylphenidate.NICE stroke recommendationsAbout half of patients with suspected stroke are initially managed in line with NICE's recommendations, according to an audit by the Royal College of Physicians (www.rcplondon.ac.uk). The College's Stroke Improvem...

Botulinum Toxin Type A: New Information about an Old Medicine.

Skin Therapy Letter — Thu, 01 Sep 2011 04:00:00 +0100

Authors: Smith KC Abstract Now that several formulations of botulinum toxin type-A (BoNT-A) are on the market in North America and throughout the world, it is of great practical importance for those who administer these medications to be familiar with the differences between the formulations. These differences pertain to the stability of the medications, in particular during the period of time between reconstitution and administration, which may affect the degree of diffusion through various tissues after injection. A variety of relatively new uses of BoNT-A for dermatological conditions will be discussed. PMID: 22089415 [PubMed - in process] (Source: Skin Therapy Letter)

Botox, surgery patients face stigma

Modern Medicine — Wed, 31 Aug 2011 23:00:00 +0100

There may be a stigma attached to invasive anti-aging treatments: Some regard them as a sign of vanity, UPI reports. (Source: Modern Medicine)

Physicians rethinking dose conversions for Botox, Dysport

Modern Medicine — Wed, 31 Aug 2011 23:00:00 +0100

The simple dose conversions used for today's neurotoxins may not result in optimal cosmetic outcomes, and this may be due to the unique nature of each individual toxin, according to a recent study. (Source: Modern Medicine)

Involuntary Craniofacial Lingual Movements in Intensive Care-Acquired Quadriplegia

Neurocritical Care — Wed, 31 Aug 2011 05:52:32 +0100

Conclusions Involuntary craniofacial lingual movements in the setting of flaccid quadriplegia following sepsis-associated encephalopathy are consistent with focal craniofacial brainstem myoclonus and constitutes a new syndrome. Botulinum toxin type A treatment maybe helpful in treatment. Content Type Journal ArticleCategory Practical PearlPages 1-6DOI 10.1007/s12028-011-9624-6Authors A. M. Cartagena, Department of Clinical Neurological Sciences, Schulich School of Medicine, The University of Western Ontario, 339 Windermere Rd, Rm B7-005, London, ON N6A 5A5, CanadaM. Jog, Department of Clinical Neurological Sciences, Schulich School of Medicine, The University of Western Ontario, 339 Windermere Rd, Rm B7-005, London, ON N6A 5A5, CanadaG. B. Young, Department of Clini...

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A note on the evaluation of BoNTA trial quality

Inflammopharmacology — Mon, 29 Aug 2011 15:57:44 +0100

Abstract In their systematic review, Zhang et al. evaluate randomized controlled trials on the efficacy of Botulinum toxin type A (BoNTA) in helping patients with musculoskeletal disorders. Scoring each trial according to the Jadad scale they note that the studies range from 1 to 5 with an average of 4.1, which they interpret as a testimony of the high quality of the studies included. Unfortunately, we cannot share the author’s enthusiasm, as a perfect Jadad score of 5 is no guarantee that a study is of good quality. Content Type Journal ArticleCategory EditorialPages 1-2DOI 10.1007/s10787-011-0089-1Authors Vance W. Berger, Biometry Research Group, National Cancer Institute, Executive Plaza North, Suite 3131, 6130 Executive Boulevard, MSC 7354, Bethesda, MD 20892-73...

FDA Approves Botox for Urinary Incontinence in Patients with Neurologic Conditions

Physician's First Watch current issue — Sun, 28 Aug 2011 23:00:00 +0100

(Source: Physician's First Watch current issue)

OnabotulinumtoxinA for Treatment of Chronic Migraine: Pooled Analyses of the 56-Week PREEMPT Clinical Program.

Headache — Sun, 28 Aug 2011 23:00:00 +0100

Conclusions.- Repeated treatment with ≤5 cycles of onabotulinumtoxinA was effective, safe, and well tolerated in adults with chronic migraine. PMID: 21883197 [PubMed - as supplied by publisher] (Source: Headache)

FDA Approves Botox to Treat Urinary Incontinence in People with Neurological Conditions Including Multiple Sclerosis and Spinal Cord Injury

American Academy of Neurology — Sat, 27 Aug 2011 17:34:20 +0100

The U.S. Food and Drug Administration approves Botox (onabotulinumtoxinA) injection to treat urinary incontinence in people with neurologic conditions such as spinal cord injury and multiple sclerosis who have overactivity of the bladder. (Source: American Academy of Neurology)

Health Buzz: Botox Approved for Bladder Problems

U.S. News - Health — Thu, 25 Aug 2011 15:35:00 +0100

Botox is a new route to migraine relief; are wrinkle creams worth it or not? (Source: U.S. News - Health)

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Anti-aging Techniques Not Yet Viewed As Acceptable According To U Of T Research

Health News from Medical News Today — Thu, 25 Aug 2011 07:00:00 +0100

Studies from the University of Toronto's psychology department show that people who use more invasive anti-aging methods such as Botox injections or surgery are viewed more negatively than those who use milder techniques such as sun-avoidance and facial creams and younger adults are more negative about using anti-aging methods than older adults. "These results suggest that despite the rapid growth of the anti-aging cosmetic industry, age concealment has not yet become universally accepted," said lead author and associate professor, Alison Chasteen... (Source: Health News from Medical News Today)

Botox Approved to Treat Urinary Incontinence

MedicineNet Migraine General — Thu, 25 Aug 2011 07:00:00 +0100

Title: Botox Approved to Treat Urinary IncontinenceCategory: Health NewsCreated: 8/24/2011 6:06:00 PMLast Editorial Review: 8/25/2011 (Source: MedicineNet Migraine General)

FDA Approves Botox to Treat Specific Form of Urinary Incontinence

MedlinePlus Health News — Thu, 25 Aug 2011 05:23:12 +0100

Source: Food and Drug Administration Related MedlinePlus Pages: Botox, Urinary Incontinence (Source: MedlinePlus Health News)

Stigma attached to cosmetic surgery, Botox

Health News - UPI.com — Thu, 25 Aug 2011 04:49:23 +0100

TORONTO, Aug. 25 (UPI) -- There is a stigma to invasive anti-aging treatments such as Botox or cosmetic surgery -- specifically, some think it is vain, Canadian researchers say. (Source: Health News - UPI.com)

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FDA approves Botox to treat a form of urinary incontinence

Drug Topics - Top News — Wed, 24 Aug 2011 23:00:00 +0100

FDA has approved onabotulinumtoxinA (Botox, Allergan) for injection for the treatment of urinary incontinence resulting from detrusor overactivity associated with a neurologic condition (e.g., spinal cord injury [SCI], multiple sclerosis [MS]) in adults who have an inadequate response to or are intolerant of an anticholinergic medication. (Source: Drug Topics - Top News)

FDA approves botulinum toxin A (Botox®) to treat specific forms of urinary incontinence

NeLM - News — Wed, 24 Aug 2011 23:00:00 +0100

Source: FDA Area: News The FDA has approved botulinum toxin A injection (Botox®) to treat urinary incontinence in people with neurological conditions such as spinal cord injury and multiple sclerosis who have an overactive bladder. The approval was based on data from two clinical studies in 691 patients which showed statistically significant decreases in the weekly frequency of incontinence episodes in the Botox group compared with placebo. The most common adverse reactions observed following injection were urinary tract infection and urinary retention. Those who develop urinary retention after Botox treatment may require self-catheterisation to empty the bladder. Botox is currently not approved for this indication in the UK. (Source: NeLM - News)

FDA approves Botox to treat a form of urinary incontinence

Modern Medicine — Wed, 24 Aug 2011 23:00:00 +0100

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Botox wins US approval as bladder treatment

FT.com - Drugs and Healthcare — Wed, 24 Aug 2011 22:43:18 +0100

Further use for cosmetic drug boosts Allergan and could generate more revenue if, as expected, the drug is approved to treat patients with overactive bladders for non-neurological reasons (Source: FT.com - Drugs and Healthcare)

Botox Approved For Urinary Incontinence In Patients With Neurologic Conditions

Health News from Medical News Today — Wed, 24 Aug 2011 21:00:00 +0100

Botox (onabotulinumtoxinA) injection for individuals with urinary incontinence (bladder overactivity) resulting from spinal cord injury, multiple sclerosis and other neurologic conditions, has been approved by the FDA (Food and Drug Administration). This type of urinary incontinence is sometimes referred to as "neurogenic bladder" or "neuropathic bladder". People with some neurological conditions can have uninhibited urinary bladder contractions, making it harder for the bladder to store urine... (Source: Health News from Medical News Today)

Botox Approved to Treat Leaky Bladder

WebMD Health — Wed, 24 Aug 2011 20:43:34 +0100

The FDA has approved the use of Botox to treat urinary incontinence due to nerve damage from conditions such as MS and spine injury. (Source: WebMD Health)

FDA approves Botox for certain bladder control issues

USATODAY.com Health — Wed, 24 Aug 2011 20:38:59 +0100

The Food and Drug Administration says it has approved Allergan's Botox injection for a new use in patients who have bladder problems caused by ... (Source: USATODAY.com Health)

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Prescriptions Blog: Botox: 'A Pipeline in a Vial'

NYT Health — Wed, 24 Aug 2011 20:00:42 +0100

Federal regulators approve using the popular drug to treat urinary incontinence, further expanding the uses for it. (Source: NYT Health)

FDA approves Botox for loss of bladder control

Reuters: Health — Wed, 24 Aug 2011 19:13:49 +0100

WASHINGTOn/NEW YORK (Reuters) - Drug regulators approved Allergan's Botox for treating a specific kind of overactive bladder on Wednesday, setting the stage for wider use of the popular wrinkle treatment in those with bladder problems. (Source: Reuters: Health)

FDA Okays Botox for Some Types of Overactive Bladder

MedPage Today OB/GYN — Wed, 24 Aug 2011 19:13:05 +0100

(MedPage Today) -- The FDA has approved botulinum toxin type A (Botox) for treating bladder overactivity resulting from spinal cord injury or multiple sclerosis. (Source: MedPage Today OB/GYN)

FDA Approves Botox to Treat Specific Form of Urinary Incontinence

Drugs.com - New Drug Approvals — Wed, 24 Aug 2011 19:08:59 +0100

SILVER SPRING, Md., Aug. 24, 2011 /PRNewswire-USNewswire/ -- The U.S. Food and Drug Administration today approved Botox (onabotulinumtoxinA) injection to treat urinary incontinence in people with neurologic conditions such as spinal cord injury... (Source: Drugs.com - New Drug Approvals)

Botox Approved for Incontinence in Neurologic ConditionsBotox Approved for Incontinence in Neurologic Conditions

Medscape Medical News Headlines — Wed, 24 Aug 2011 19:05:36 +0100

The FDA has announced approval for onabotulinumtoxinA to treat urinary incontinence resulting from detrusor overactivity in patients with conditions such as spinal cord injury or multiple sclerosis. Medscape Medical News (Source: Medscape Medical News Headlines)

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Botox Approved to Treat Urinary Incontinence

The Doctors Lounge - Urology — Tue, 23 Aug 2011 23:00:00 +0100

Among people with certain neurologic conditions (Source: The Doctors Lounge - Urology)

FDA approves Botox for loss of bladder control

Modern Medicine — Tue, 23 Aug 2011 23:00:00 +0100

WASHINGTON/NEW YORK (Reuters) - The U.S. Food and Drug Administration approved Allergan's Botox on Wednesday for treating detrusor overactivity associated with a neurologic condition such as multiple sclerosis or spinal cord injury. (Source: Modern Medicine)

U of T research shows anti-aging techniques not yet viewed as acceptable

EurekAlert! - Social and Behavioral Science — Tue, 23 Aug 2011 04:00:00 +0100

(University of Toronto) Studies from the University of Toronto's psychology department show that people who use more invasive anti-aging methods such as Botox injections or surgery are viewed more negatively than those who use milder techniques such as sun-avoidance and facial creams and younger adults are more negative about using anti-aging methods than older adults. (Source: EurekAlert! - Social and Behavioral Science)

Prevention of Anastomotic Thrombosis by Botulinum Toxin B After Acute Injury in a Rat Model

The Journal of Hand Surgery — Mon, 22 Aug 2011 04:00:00 +0100

Conclusions: BTX-B prevented or reduced the incidence of thrombosis after acute vessel anastomosis in this rat model at all time points less than 120 hours compared with placebo. The average final vessel diameter throughout the series of BTX-B–treated vessels was significantly larger than in the control group.Clinical relevance: The use of BTX-B may improve the success rate of microvascular anastomoses by being protective against vasospastic stress and subsequent thrombosis. (Source: The Journal of Hand Surgery)

Commercial speech and off-label drug uses: what role for wide acceptance, general recognition and research incentives?

American Journal of Law and Medicine — Sat, 20 Aug 2011 13:22:11 +0100

This article provides an overview of how the constitutional protections for commercial speech affect the Food and Drug Administration's (FDA) regulation of drugs, and the emerging issues about the scope of these protections. A federal district court has already found that commercial speech allows manufacturers to distribute reprints of medical articles about a new off-label use of a drug as long as it contains disclosures to prevent deception and to inform readers about the lack of FDA review. This paper summarizes the current agency guidance that accepts the manufacturer's distribution of reprints with disclosures. Allergan, the maker of Botox, recently maintained in a lawsuit that the First Amendment permits drug companies to provide "truthful information" to doctors about "widely accept...

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Botulinum toxin treatment in upper limb spasticity: Treatment consistency.

European Journal of Paediatric Neurology — Thu, 18 Aug 2011 23:00:00 +0100

This study assessed treatment consistency of botulinum toxin administration in spastic upper limbs under pragmatic conditions, as derived through stability of dosages and between injections intervals. Over a period of 8 years, 153 children (81 with bilateral spastic cerebral palsy, 72 with unilateral) were treated according to accepted, experience-based guidelines with Botox and Dysport. Treatment response was based on assessment of spasticity and attainment of pre-determined goals at 3, 6 and 12 months post each treatment. Mean age at treatment onset was 6y 4mo (SD: 4y 10mo), median F/U, 2.5 years (4 months-6 8/12 years). Number of injection sessions was 1-10; few had more than 6 sessions. In 106 (69.28%) children, more than one anatomic regions of the limb were injected. Most (56.2%), ha...

XEOMIN (Botulinum Toxin Type A) Injection, Powder, Lyophilized, For Solution [Merz Aesthetics. Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 18 Aug 2011 05:00:00 +0100

Updated Date: Aug 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Botulinum toxin type A treatment in children with cerebral palsy: Evaluation of treatment success or failure by means of goal attainment scaling.

European Journal of Paediatric Neurology — Fri, 12 Aug 2011 23:00:00 +0100

CONCLUSION: Age, level of treatment and casting seem to be crucial features of BTX-A treatment success or failure in children with CP. PMID: 21843959 [PubMed - as supplied by publisher] (Source: European Journal of Paediatric Neurology)

Botox migraine treatment to be assessed by NICE

Healthcare Republic News — Thu, 11 Aug 2011 09:15:00 +0100

Treatment of migraine with botulinum toxin type A is to be assessed by NICE, details of the institute's latest work programme reveal. (Source: Healthcare Republic News)

Botox sales outpace forecasts

Modern Medicine — Wed, 10 Aug 2011 23:00:00 +0100

Sales of Botox (onabotulinumtoxinA, Allergan) climbed 16 percent in second quarter 2011 compared to the previous year, the company announced. (Source: Modern Medicine)

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Botulinum toxin improves urinary symptoms in Parkinson's

Modern Medicine — Wed, 10 Aug 2011 23:00:00 +0100

NEW YORK (Reuters Health) - Botulinum toxin type A injections are helpful in patients with Parkinson's disease and overactive bladder, Italian researchers report in a July 24th on-line paper in The Journal of Urology. (Source: Modern Medicine)

The Use of Botox in the Treatment of Post Cardiac Surgery Paradoxical Vocal Cord Movement

Heart, Lung and Circulation — Wed, 10 Aug 2011 16:29:00 +0100

We report a case of a 65 year-old man who developed severe PVCM post coronary artery bypass surgery requiring tracheostomy for six months. He was successfully treated with bronchoscopic injection of Botulinum toxin type A into his vocal cords. He was decannulated one week after the injection, and was doing well at six weeks follow up. (Source: Heart, Lung and Circulation)

NICE work programme referrals - July 2011

NeLM - News — Tue, 09 Aug 2011 23:00:00 +0100

Source: Department of Health (DH) Area: News Ministers have agreed that the following single technology appraisal topics should be finally referred to the NICE work programme: . Botulinum toxin type A for the prophylaxis of headaches associated with chronic migraine . Lenalidomide for the maintenance treatment of multiple myeloma after autologous stem cell transplantation . Lenalidomide as induction therapy for newly diagnosed multiple myeloma . Lenalidomide as maintenance therapy for newly diagnosed multiple myeloma in people who have previously received induction chemotherapy . Lenalidomide for the treatment of myelodysplastic syndromes associated with a deletion 5q cytogenetic abnormality in people with red...

BOTOX approved for urinary incontinence treatment

Pharmacy Europe — Tue, 09 Aug 2011 15:41:00 +0100

Approval from Irish Medicines Board relates to patients with MS and SRI (Source: Pharmacy Europe)

Botox For Urinary Incontinence For MS Or Spinal Cord Injury Patents, Positive Opinion In Europe

Health News from Medical News Today — Mon, 08 Aug 2011 17:00:00 +0100

The Irish Medicines Board has given a positive opinion for Botox (botulinum toxin type A) for urinary incontinence management in adults with NDO (neurogenic detrusor overactivity) resulting from neurogenic bladder due to multiple sclerosis or stable sub-cervical spinal cord injury, Allergan Inc. has announced. Allergan says this step is an important one toward securing national licences in 14 European nations which are involved int he Mutual Recognition Procedure. The positive opinion came after the Irish regulatory agency evaluated Allergan's successful global Phase III program... (Source: Health News from Medical News Today)

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Botox gets EU green light for bladder problem

Multiple Sclerosis Trust — Sun, 07 Aug 2011 23:00:00 +0100

Botox, the anti-wrinkle drug, has won a green light in Europe for treating certain patients with urinary incontinence, opening up a potentially important new market for its maker Allergan. (Source: Multiple Sclerosis Trust)

Minimally invasive surgery for achalasia in patients >40 years: more favorable than anticipated

Langenbeck's Archives of Surgery — Fri, 05 Aug 2011 05:54:01 +0100

Conclusions Laparoscopic Heller myotomy for achalasia is associated with a high success rate as the primary therapeutic option and after failure of endoscopic therapy. It can be performed safely and with favorable outcomes also in patients >40 years. However, the long-term durability of the procedure remains to be established. Content Type Journal ArticlePages 1-6DOI 10.1007/s00423-011-0832-5Authors Ines Gockel, Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Langenbeckstr. 1, 55131 Mainz, GermanyAlexandra Gith, Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Langenbeckstr. 1, 55131 Mainz, GermanyDaniel Drescher, Department of General and Abdominal Surgery, Johannes Gutenberg Universit...

BOTOX (Onabotulinumtoxina) Injection, Powder, Lyophilized, For Solution [Allergan, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 05 Aug 2011 05:00:00 +0100

Updated Date: Aug 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BOTOX COSMETIC (Onabotulinumtoxina) Injection, Powder, Lyophilized, For Solution [Allergan, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 05 Aug 2011 05:00:00 +0100

Updated Date: Aug 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effects of treadmill running on rat gastrocnemius function following botulinum toxin A injection

Journal of Orthopaedic Research — Thu, 04 Aug 2011 02:48:12 +0100

AbstractExercise can improve and maintain neural or muscular function, but the effects of exercise in physiological adaptation to paralysis caused by botulinum toxin A has not been well studied. Twenty‐four rats were randomly assigned into control and treadmill groups. The rats assigned to the treadmill group were trained on a treadmill three times per week with the running speed set at 15 m/min. The duration of training was 20 min/session. Muscle strength, nerve conduction study and sciatic functional index (SFI) were used for functional analysis. Treadmill training improved the SFI at 2, 3, and 4 weeks (p = 0.01, 0.004, and 0.01, respectively). The maximal contraction force of the gastrocnemius muscle in the treadmill group was greater than in the control group (p < 0.05...

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Overactive bladder may be next frontier for Botox

Reuters: Health — Wed, 03 Aug 2011 19:52:04 +0100

NEW YORK (Reuters) - Overactive bladders later this year could become the next big frontier for Botox, the anti-wrinkle drug, and significantly boost sales of the $1.5 billion-a-year product, according to company Chief Executive David Pyott. (Source: Reuters: Health)

Botulinum Toxin Decreases Hyperalgesia and Inhibits P2X3 Receptor Over‐Expression in Sensory Neurons Induced by Ventral Root Transection in Rats

Pain Medicine — Mon, 01 Aug 2011 23:00:00 +0100

Conclusions. L5 VRT led to over‐expression of P2X3 receptors in the L5 DRG and bilateral mechanical allodynia in rats. Subcutaneous injection of BTX‐A significantly reversed the neuropathic pain behavior and the over‐expression of P2X3 receptor in nociceptive neurons. These data not only show over‐expression of purinergic receptors in the VRT model of neuropathic pain but also reveal a novel mechanism of botulinum toxin action on nociceptive neurons. (Source: Pain Medicine)

Efficacy of Management Algorithm for Reducing Need for Sphincterotomy in Chronic Anal Fissures

Colorectal Disease — Sun, 31 Jul 2011 23:00:00 +0100

Conclusion: Our algorithm is effective in CAF and the majority responds to conservative management. Only 26.3% of all patients require surgery, which is effective but also carries some temporary morbidity. (Source: Colorectal Disease)

Intradermal injection of Botulinum toxin type A alleviates infraorbital nerve constriction‐induced thermal hyperalgesia in an operant assay

Journal of Oral Rehabilitation — Thu, 28 Jul 2011 01:02:31 +0100

Summary Recent studies have shown that infraorbital nerve constriction (IoNC)‐induced mechanical allodynia has been attenuated by administration of highly purified 150‐kDa Botulinum neurotoxin type A (BoNT/A). Here, we extend these studies to determine whether BoNT/A could attenuate IoNC‐induced symptoms of thermal hyperalgesia. Instead of testing head withdrawal thresholds, a thermal operant assay was used to evaluate cortical processing of sensory input following IoNC. In this assay, a fasted rat’s desire to obtain a food reward (sweetened condensed milk) is coupled to its ability to tolerate facial contact with a warm (45 °C) thermode. Bilateral IoNC decreased the ratio of thermode contact duration/event, which is an indicative of thermal hyperalgesia. BoNT/A injection int...