MedWorm: Cefadroxil

Baxan capsules and suspension (Cefadroxil) - Revised SPC

NeLM - SPC Changes — Mon, 25 Jan 2010 00:00:00 +0100

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC includes changes to: Section 4.2 - Posology and method of administration Renal Impairment Dosage : In patients with renal impairment, the dosage should be adjusted according to creatinine clearance rates to prevent drug accumulation and serum levels should be monitored. The following schedule is suggested. In adults, the initial dose of 1g of Baxan and the maintenance dose (based on the creatinine clearance rate) is 500mg at the time intervals listed below: Creatinine Clearance (mL/min/1.73m2) and Dose Interval 0 - 10 36 hrs 11 - 25 24 hrs 26 - 50 12 hrs Patients with creatinine clearance rates o...

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Clinical efficacy and tolerability of linezolid in pediatric patients: A systematic review.

Clinical Therapeutics — Fri, 01 Jan 2010 00:00:00 +0100

Conclusions: The reviewed pediatric studies in skin and skin-structure infections, bacteremia, or pneumonia found that linezolid was associated with high clinical cure rates (75.0%-93.2%) that did not differ significantly from those of vancomycin or cefadroxil. RCTs enrolling children with other types of infection (eg, osteomyelitis, endocarditis), as well as long-term studies, are needed to draw definitive conclusions about linezolid's efficacy and tolerability in pediatric patients. Careful monitoring for adverse events and possible linezolid resistance continues to be essential. PMID: 20171414 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)

Cefadroxil: Acute generalised exanthematous pustulosis (first report) in a child: case report.

Reactions Weekly — Wed, 29 Apr 2009 00:48:54 +0100

Page: 13 (Source: Reactions Weekly)

Cefadroxil: Acute generalised exanthematous pustulosis (first report) in a child: case report

Reactions — Sun, 26 Apr 2009 04:55:40 +0100

(Source: Reactions)

cefadroxil, Duricef

MedicineNet Medications General — Thu, 12 Mar 2009 07:00:00 +0100

Title: cefadroxil, DuricefCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 3/12/2009 (Source: MedicineNet Medications General)

Characterization of the interaction of cefadroxil with different metal ions using CE

Electrophoresis — Thu, 19 Feb 2009 05:00:00 +0100

This study aims at quantifying the interaction of cefadroxil with Zn2+, Al3+, Fe3+, Cu2+ and Co2+ ions using the effective electrophoretic mobility as a parameter for calculation of the reaction association constant (K). For this purpose, the electrophoretic mobilities of cefadroxil at different metal ion concentrations in citrate buffer pH 3.6 were determined. A mathematical model to calculate the association constant between cefadroxil and metal ions was used. The results showed that a strong change in the cefadroxil electrophoretic mobility was observed by increasing the metal ion concentrations. The results revealed that by increasing the concentration of metal ions in the running buffer the degree of complexation increases too. On the basis of the results, the strength of the interact...

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Development and validation of an immunochromatographic assay for rapid multi-residues detection of cephems in milk.

Analytica Chimica Acta — Fri, 23 Jan 2009 07:33:46 +0100

In conclusion, the method was rapid and accurate for the multi-residue detection of cephems in milk. PMID: 19154821 [PubMed - in process] (Source: Analytica Chimica Acta)

Evaluation of Enterococcus mundtii ST4SA and Lactobacillus plantarum 423 as probiotics by using a gastro-intestinal model with infant milk formulations as substrate.

International Journal of Food Microbiology — Wed, 01 Oct 2008 04:00:00 +0100

Authors: Botes M, van Reenen CA, Dicks LM Enterococcus mundtii ST4SA and Lactobacillus plantarum 423 produce bacteriocins with activity against a number of Gram-positive and Gram-negative bacteria. Both strains survived intestinal conditions simulated in a gastro-intestinal model (GIM) with infant milk formulations as substrate and prevented the growth of Listeria monocytogenes ScottA. The strains are inhibited by the antibiotics amoxicillin, cefadroxil, roxithromycin and doxycycline, anti-inflammatory medicaments containing meloxicam, ibuprofen and sodium diklofenak, and analgesics containing paracetamol, codeine phosphate and promethazine. Strain 423 is sensitive to vancomycin and does not contain genes encoding gelatinase, cell aggregation substance (AS), adhesion to collagen (Ace),...

Cefadroxil(Cefadroxil) Tablet [Teva Pharmaceuticals USA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 25 Jul 2008 05:00:00 +0100

Updated Date: Jul 25, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Bioequivalence study of two oral formulations of cefadroxil in healthy volunteers.

Arzneimittel-Forschung — Mon, 07 Jul 2008 18:03:49 +0100

Authors: Kano EK, Porta V, Koono EE, Schramm SG, Serra CH Two different cefadroxil (CAS 50370-12-2) formulations were evaluated for their relative bioavailability in 24 healthy volunteers who received a single 500 mg oral dose of each preparation. An open, randomized clinical trial designed as a two-period crossover study with a 7-day washout period between doses was employed. Plasma samples for assessments of their cefadroxil concentration by HPLC-UV were obtained over 8 h after administration. Values of 48.94 +/- 10.18 pg x h/ml for test, and 48.51 +/- 9.02 microg x h/ml for the reference preparation AUC(0-t) demonstrate a nearly identical extend of drug absorption. Maximum plasma concentration Cmax of 16.04 +/- 4.94 microg/ml and 16.01 + 4.02 microg/ml achieved for the test and refe...

Cefadroxil(Cefadroxil) Tablet, Film Coated [West-Ward Pharmaceutical Corp.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 02 Jul 2008 05:00:00 +0100

Updated Date: Jul 2, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Novel beta-lactam antibiotics synthesized by amination of catechols using fungal laccase.

Chemical and Pharmaceutical Bulletin — Tue, 01 Jul 2008 04:00:00 +0100

Authors: Mikolasch A, Wurster M, Lalk M, Witt S, Seefeldt S, Hammer E, Schauer F, Jülich WD, Lindequist U Novel cephalosporins, penicillins, and carbacephems were synthesized by amination of catechols with amino-beta-lactams like cefadroxil, amoxicillin, ampicillin and the structurally related carbacephem loracarbef using laccase from Trametes sp. All isolated monoaminated products inhibited the growth of several Gram positive bacterial strains in the agar diffusion assay, among them methicillin-resistant Staphylococcus aureus strains and vancomycin-resistant Enterococci. Observed differences in the cytotoxicity and in vivo activity in a "Staphylococcus-infected, immune suppressed mouse" model are discussed. PMID: 18591799 [PubMed - in process] (Source: Chemical and Pharmaceut...

Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2

AJP: Renal Physiology — Thu, 05 Jun 2008 04:00:00 +0100

The human proton/oligopeptide cotransporters hPEPT1 and hPEPT2 have been targeted to enhance the bioavailability of drugs and prodrugs. Previously, we established the mechanisms of drug transport by hPEPT1. Here, we extend these studies to hPEPT2. Major variants hPEPT2*1 and hPEPT2*2 were expressed in Xenopus oocytes, and each was examined using radiotracer uptake and electrophysiological methods. Glycylsarcosine (Gly-Sar); the β-lactam antibiotics ampicillin, amoxicillin, cephalexin, and cefadroxil; and the anti-neoplastics -aminolevulinic acid (-ALA) and bestatin induced inward currents, indicating that they are transported. Variations in transport rate were due to differences in affinity and in turnover rate: for example, cefadroxil was transported with higher apparent affinity but...

What is the Diagnostic Criteria for PANDAS?

PediatricEducation.org — Mon, 02 Jun 2008 15:28:37 +0100

Discussion PANDAS is an acronym which stands for pediatric autoimmune neuropsychiatric disease associated with streptococcal disease. It was first described in 1998. The exact pathophysiology is not known but various evidence supports an autoimmune mediated mechanism. The proposed mechanism is that streptococcal infection produces antibodies that are capable of cross-reacting with specific areas of the brain such as the basal ganglia and then produces behavioral and neuropsychiatric symptoms. Current treatment is controversial because of lack of research studies. Antibiotic treatment for evidence of current streptococcal infection is usually given. Prophylactic antibiotic treatment is not recommended. Neuropsychiatric drugs are used for treatment of disabling tics and/or OCD in additio...

Molecular Mechanism of Dipeptide and Drug Transport by the Human Renal H+/Oligopeptide Cotransporter, hPEPT2.

Am J Physiol Renal P... — Wed, 26 Mar 2008 04:00:00 +0100

Authors: Sala-Rabanal M, Loo DD, Hirayama BA, Wright EM The human proton/oligopeptide cotransporters, hPEPT1 and hPEPT2, have been targeted to enhance the bioavailability of drugs and prodrugs. Previously, we established the mechanisms of drug transport by hPEPT1. Here, we extend these studies to hPEPT2. Major variants hPEPT2*1 and hPEPT2*2 were expressed in Xenopus oocytes, and each was examined using radiotracer uptake and electrophysiological methods. Gly-Sar, the beta-lactam antibiotics ampicillin, amoxicillin, cephalexin and cefadroxil, and the antineoplastics delta-aminolevulinic acid (delta-ALA) and bestatin induced inward currents, indicating that they are transported. Variations in transport rate were due to differences in affinity and in turnover rate: for example, cefadroxil...

Cefadroxil(Cefadroxil) Tablet, Film Coated [ORCHID HEALTHCARE (A DIVISION OF ORCHID CHEMICALS AND PHARMACEUTICALS LTD.)]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 05 Feb 2008 05:00:00 +0100

Updated Date: Feb 5, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Cefadroxil(Cefadroxil) Powder, For Suspension [ORCHID HEALTHCARE (A DIVISION OF ORCHID CHEMICALS AND PHARMACEUTICALS LTD.)]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 31 Jan 2008 05:00:00 +0100

Updated Date: Jan 31, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cefadroxil(Cefadroxil) Capsule [ORCHID HEALTHCARE (A DIVISION OF ORCHID CHEMICALS AND PHARMACEUTICALS LTD.)]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 21 Dec 2007 05:00:00 +0100

Updated Date: Dec 21, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FDA Safety Changes: Fluoroquinolones and Other Antimicrobial Drugs

Medscape Pathology Headlines — Wed, 26 Sep 2007 21:00:00 +0100

The FDA has approved revisions to the safety labeling for ciprofloxacin, ofloxacin, levofloxacin, sulfamethoxazole/trimethoprim, cefadroxil, nitrofurantoin, and cefpodoxime proxetil. Medscape Medical News (Source: Medscape Pathology Headlines)

Cefadroxil(Cefadroxil) Capsule [Aurobindo Pharma Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 26 Jul 2007 05:00:00 +0100

Updated Date: Jul 26, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cefadroxil: First report of DRESS syndrome: case report

Reactions — Mon, 16 Jul 2007 13:48:26 +0100

(Source: Reactions)

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Cefadroxil: First report of DRESS syndrome: case report.

Reactions Weekly — Sat, 14 Jul 2007 01:37:43 +0100

Page: 13 (Source: Reactions Weekly)

DRESS syndrome from cefadroxil confirmed by positive patch test

Allergy — Mon, 18 Jun 2007 09:05:44 +0100

Allergy Volume 0, Issue 0, Page ???-???. (Source: Allergy)

Determination of beta-lactam antibiotics in milk using micro-flow chemiluminescence system with on-line solid phase extraction.

Analytica Chimica Acta — Tue, 22 May 2007 21:50:08 +0100

Authors: Liu W, Zhang Z, Liu Z In this paper, a chemiluminescence (CL) micro-flow system combined with on-line solid phase extraction (SPE) is presented for determination of beta-lactam antibiotics (penicillin, cefradine, cefadroxil, cefalexin) in milk. It is based on the enhancement effect of beta-lactam antibiotics on the luminol-K(3)Fe(CN)(6) CL system. The micro-flow system was fabricated from two polymethyl methacrylate (PMMA) plates (50mmx40mmx5mm) with the microchannels of 200mum wide and 150mum deep. C(18)-modified silica gel was packed into the microchannel (length: 10mm; width: 1mm; depth: 500mum) to serve as SPE device. Extraction and preconcentration of the analytes were carried out using on-line SPE micro-flow system and the selectivity of CL detection was improved. The de...

Duricef(Cefadroxil) Powder, For Suspension Duricef(Cefadroxil) Tablet Duricef(Cefadroxil) Capsule [Warner Chilcott, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 May 2007 05:00:00 +0100

Updated Date: May 22, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cefadroxil(Cefadroxil) Capsule [Teva Pharmaceuticals USA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 May 2007 05:00:00 +0100

Updated Date: May 22, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Multi-objective optimization of an industrial penicillin V bioreactor train using non-dominated sorting genetic algorithm

Biotechnology and Bioengineering — Tue, 03 Apr 2007 04:00:00 +0100

Bulk of the penicillin produced is used as raw material for semi-synthetic penicillin (such as amoxicillin and ampicillin) and semi-synthetic cephalosporins (such as cephalexin and cefadroxil). In the present paper, an industrial penicillin V bioreactor train is optimized for multiple objectives simultaneously. An industrial train, comprising a bank of identical bioreactors, is run semi-continuously in a synchronous fashion. The fermentation taking place in a bioreactor is modelled using a morphologically structured mechanism. For multi-objective optimization for two and three objectives, the elitist Non-dominated Sorting Genetic Algorithm (NSGA-II) is chosen. Instead of a single optimum as in the traditional optimization, a wide range of optimal design and operating conditions depicting t...

European Surveillance of Antimicrobial Consumption (ESAC): outpatient cephalosporin use in Europe

Journal of Antimicrobial Chemotherapy — Mon, 17 Jul 2006 06:00:00 +0100

Conclusion: The new ATC codes allow a more detailed description of outpatient cephalosporin use. The variation in antibiotic use in Europe is most extreme for this class of antibiotics, suggesting that in many countries in Europe these antibiotics are prescribed inappropriately. (Source: Journal of Antimicrobial Chemotherapy)

Determination of cefadroxil by sequential injection with spectrophotometric detector.

Anal Sci — Fri, 14 Apr 2006 06:00:00 +0100

Authors: Makchit J, Upalee S, Thongpoon C, Liawruangrath B, Liawruangrath S A sequential injection analysis (SIA) spectrophotometric procedure for cefadroxil determination has been developed. The SIA instrumentation was modified to achieve the desired function and operations by using the software developed to interface the PC with the conventional SIA system. The method is based on the measurement of a red, water-soluble product formed by the reaction between cefadroxil and 4-aminoantipyrine in the presence of alkaline potassium hexacyanoferrate(III) at 510 nm. Optimum conditions for determining the drug were investigated. Beer's law was obeyed over the concentration ranges of 1 - 10 mg L(-1) and 10 - 50 mg L(-1) with a detection limit (3 sigma) of 0.17 mg L(-1) and a limit of quantifi...