MedWorm: Cefprozil

Efficient biocatalyst for large-scale synthesis of cephalosporins, obtained by combining immobilization and site-directed mutagenesis of penicillin acylase.

Applied Microbiology and Biotechnology — Sun, 08 Jan 2012 05:00:00 +0100

We describe the rational design of a new efficient biocatalyst and the development of a sustainable green process for the synthesis of cephalosporins bearing a NH(2) group on the acyl side chain. The new biocatalyst was developed starting from the WT penicillin acylase (PA) from Escherichia coli by combining enzyme mutagenesis, in position α146 and β24 (βF24A/αF146Y), and immobilization on an appropriate modified industrial support, glyoxyl Eupergit C250L. The obtained derivative was used in the kinetically controlled synthesis of cephalexin, cefprozil and cefaclor and compared to the WT-PA and an already described mutant, PA-βF24A, with improved properties. The new biocatalyst posses a very high ratio between the rates of the synthesis and two undesired hydrolyses (acylating ester an...

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CEFPROZIL (Cefprozil) Tablet [H. J. Harkins Company, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 16 Nov 2011 05:00:00 +0100

Updated Date: Nov 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CEFPROZIL (Cefprozil) Tablet [LUPIN PHARMACEUTICALS INC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 24 Jun 2011 05:00:00 +0100

Updated Date: Jun 24, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Ionization constants and solubility of compounds involved in enzymatic synthesis of aminopenicillins and aminocephalosporins.

Bioprocess and Biosystems Engineering — Wed, 22 Jun 2011 23:00:00 +0100

Authors: Kurochkina VB, Sklyarenko AV, Satarova JE, Yarotsky SV The article deals with experimental determination of ionization constants and solubility for the compounds (target products, initial β-lactams, acylating agents and by-products) involved in enzymatic synthesis of some therapeutically used aminopenicillins and aminocephalosporins, namely ampicillin, amoxicillin, cephalexin, cephadroxil, cephaloglycin, cefaclor, cefprozil, cefatrizine. Methodology of investigations and the evaluation of experimental data for the determination of ionization constants and solubility of the different type electrolytes are presented. Applications of the methods based on acid-base potentiometric titration and on determination of solubility-pH dependence of assayed substances are discussed. The o...

CEFPROZIL (Cefprozil) Powder, For Suspension [LUPIN PHARMACEUTICALS INC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 28 Apr 2011 05:00:00 +0100

Updated Date: Apr 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Reversal of refractory sulfasalazine-related renal failure after treatment with corticosteroids.

Clinical Therapeutics — Fri, 01 Oct 2010 00:00:00 +0100

Conclusions: Although this isolated case of sulfasalazine- related interstitial nephritis cannot lead to definite conclusions, treatment with corticosteroids was effective in this patient and should be considered irrespective of the time of exposure to sulfasalazine. However, randomized controlled trials are needed to provide evidence regarding the efficacy and tolerability profile of corticosteroids. PMID: 21095485 [PubMed - in process] (Source: Clinical Therapeutics)

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Self-medication with antibiotics in rural population in Greece: a cross-sectional multicenter study

BMC Family Practice — Sat, 07 Aug 2010 23:00:00 +0100

Conclusion: In Greece, despite the open and rapid access to primary care services, it appears that a high proportion of rural adult population use antibiotics without medical prescription preferably for fever and common cold. (Source: BMC Family Practice)

Aurobindo gets approval from Canada for antibiotic drug

The Economic Times Healthcare and Biotech News — Fri, 16 Apr 2010 08:47:37 +0100

Pharma firm Aurobindo Pharma on Friday said it has received approval from Health Canada for introducing its Cefprozil tablets and Cefprozil powder for oral suspension as an antibiotic. (Source: The Economic Times Healthcare and Biotech News)

Interaction of the heptavalent pneumococcal conjugate vaccine and the use of individual antibiotics among children on nasopharyngeal colonization with erythromycin-resistant Streptococcus pneumoniae

European Journal of Clinical Microbiology & Infectious Diseases — Thu, 26 Nov 2009 07:59:49 +0100

Abstract The purpose of this study was to assess the complex interaction of the heptavalent pneumococcal conjugate vaccine (PCV7) and individual classes of antimicrobial agents on the nasopharyngeal carriage of erythromycin-resistant pneumococci within the day-care center population. Between February 2005 and May 2007, nasopharyngeal cultures for Streptococcus pneumoniae were obtained from 1,829 day-care center attendees in Central Greece. Thirty-one percent of the pneumococci were erythromycin-resistant; 85.2% of these isolates were also penicillin-nonsusceptible. PCV7 immunization was associated with decreased carriage of erythromycin-resistant PCV7 serotypes but not with an overall decrease in erythromycin-resistant S. pneumoniae colonization. The largest decline in the c...

Cefprozil: First report of acute generalised exanthematous pustulosis with severe organ dysfunction: case report

Reactions — Sun, 22 Nov 2009 14:04:51 +0100

(Source: Reactions)

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cefprozil, Cefzil

MedicineNet Allergies General — Thu, 08 Oct 2009 07:00:00 +0100

Title: cefprozil, CefzilCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 10/8/2009 (Source: MedicineNet Allergies General)

Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics

Journal of Antimicrobial Chemotherapy — Wed, 11 Feb 2009 05:00:00 +0100

Conclusions Despite high rates of β-lactamase production among non-typeable H. influenzae and M. catarrhalis, multiple oral treatment options exist for non-typeable H. influenzae and M. catarrhalis. Multidrug-resistant serotype 19A S. pneumoniae (~20%) limits treatment options for ambulatory S. pneumoniae respiratory disease. (Source: Journal of Antimicrobial Chemotherapy)

Probability of Achieving Requisite Pharmacodynamic Exposure for Oral beta-Lactam Regimens against Haemophilus influenzae in Children.

Paediatric Drugs — Thu, 13 Nov 2008 16:53:44 +0100

CONCLUSION: Against H. influenzae, the antibacterials most likely to achieve optimal in vivo exposures in children are cefpodoxime, ceftibuten, and amoxicillin/clavulanic acid. PMID: 18998749 [PubMed - in process] (Source: Paediatric Drugs)

Pharmacodynamic Target Attainment of Oral beta-Lactams for the Empiric Treatment of Acute Otitis Media in Children.

Paediatric Drugs — Sun, 31 Aug 2008 13:27:11 +0100

CONCLUSIONS: Based on the recent epidemiologic and resistance profiles of S. pneumoniae and H. influenzae, amoxicillin/clavulanic acid (45 mg/kg every 12 hours) and cefpodoxime (5 mg/kg every 12 hours) provide the greatest likelihood of achieving optimal pharmacodynamic exposures empirically in children with AOM. PMID: 18754699 [PubMed - in process] (Source: Paediatric Drugs)

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Cefprozil(CEFPROZIL) Tablet, Film Coated [ORCHID HEALTHCARE (A DIVISION OF ORCHID CHEMICALS AND PHARMACEUTICALS LTD.)]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 22 May 2008 05:00:00 +0100

Updated Date: May 22, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antimicrobial activity of cefditoren tested against contemporary (2004-2006) isolates of Haemophilus influenzae and Moraxella catarrhalis responsible for community-acquired respiratory tract infections in the United States.

Diagnostic Microbiology and Infectious Disease — Tue, 18 Mar 2008 04:00:00 +0100

Authors: Biedenbach DJ, Jones RN, Fritsche TR Among orally administered cephalosporins, aminopenicillins (+/-clavulanate), and macrolides, cefditoren was the most potent agent against Haemophilus influenzae (MIC(50/90), </=0.008/0.03 mug/mL; 316 isolates including 100 beta-lactamase-positive and 10 beta-lactamase-negative ampicillin-resistant [BLNAR]) and was 32-, 64-, and 512-fold more potent than cefdinir, cefuroxime, and cefprozil, respectively. Cefditoren (MIC(50), 0.03 mug/mL) was also >/=32-fold more active against BLNAR phenotypes, although newer macrolides provided complete coverage against these strains. All Moraxella catarrhalis isolates were inhibited by cefditoren (0.5 mug/mL), including beta-lactamase producers (MIC(50), 0.12 vs </=0.008 mug/mL). Cefditoren retain...

Cefzil(CEFPROZIL) Tablet, Film Coated Cefzil(CEFPROZIL) Powder, For Suspension [Bristol-Myers Squibb]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 05 Mar 2008 05:00:00 +0100

Updated Date: Mar 5, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Comparison of the effect of benzathine penicillin G, clarithromycin, cefprozil and amoxicillin/clavulanate on the bacteriological response and throat flora in group A beta hemolytic streptococcal tonsillopharyngitis.

The Turkish Journal of Pediatrics — Sat, 01 Mar 2008 05:00:00 +0100

Authors: Yildirim I, Ceyhan M, Gür D, Kaymakoğlu I Bacteriological failure with penicillin that has been used widely for years in group A beta hemolytic streptococcal (GABHS) tonsillopharyngitis is being reported as high as 30%. Because of this unresponsiveness, many different agents are being used as alternative options. We evaluated the effect of clarithromycin, amoxicillin/clavulanate (CAM), cefprozil and benzathine penicillin G (Pen G) on the bacteriological cure, beta-lactamase production, pharyngeal microflora and alpha hemolytic streptococci (AHS) when used in the treatment of pediatric GABHS tonsillopharyngitis. Intramuscular Pen G and oral clarithromycin, CAM and cefprozil were administered to 70 patients who were between 2-16 years of age. Three throat swabs were o...

Cefprozil(Cefprozil) Tablet, Film Coated [TEVA PHARMACEUTICALS USA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 27 Feb 2008 05:00:00 +0100

Updated Date: Feb 27, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Cefprozil(CEFPROZIL) Powder, For Suspension [ORCHID HEALTHCARE (A DIVISION OF ORCHID CHEMICALS AND PHARMACEUTICALS LTD.)]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 27 Feb 2008 05:00:00 +0100

Updated Date: Feb 27, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cefprozil(CEFPROZIL) Tablet, Film Coated [ORCHID HEALTHCARE (A DIVISION OF ORCHID CHEMICALS AND PHARMACEUTICALS LTD.)]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 22 Feb 2008 05:00:00 +0100

Updated Date: Feb 22, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cefprozil(Cefprozil) Tablet, Film Coated [Lupin Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 25 Jan 2008 05:00:00 +0100

Updated Date: Jan 25, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cefprozil(CEFPROZIL) Powder, For Suspension [Lupin Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 25 Jan 2008 05:00:00 +0100

Updated Date: Jan 25, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cefprozil(Cefprozil) Powder, For Suspension [Aurobindo Pharma Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 25 Jan 2008 05:00:00 +0100

Updated Date: Jan 25, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Redefining the management of pediatric tonsillopharyngitis with Cefprozil

Indian Journal of Pediatrics — Mon, 21 Jan 2008 16:13:25 +0100

Abstract Tonsillopharyngitis is very common in children, with Group A Streptococci being the most common bacterial etiology. Effective antibacterial treatment is imperative due to risk of rheumatic fever. Cephalosporins have been used successfully for the treatment of Group A beta-hemolytic Streptococcal (GABHS) tonsillopharyngitis. Cefprozil is a novel broad-spectrum oral cephalosporin. Cefprozil is rapidly absorbed from the gastrointestinal tract with high bioavailability. The excellent penetration of cefprozil into tonsillar and adenoidal tissue corresponds well with the clinical outcome. The drug provides excellent coverage against both gram-negative and-positive bacteria that may cause pharyngitis/tonsillitis. The beta-lactamase stability of cefprozil appears to excee...

Cefprozil(Cefprozil) Tablet, Film Coated [Lek Pharmaceuticals Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 10 Oct 2007 05:00:00 +0100

Updated Date: Oct 10, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A survey of antibiotic resistance in Streptococcus pneumoniae and Haemophilus influenzae in Turkey, 2004 2005

Journal of Antimicrobial Chemotherapy — Tue, 14 Aug 2007 04:00:00 +0100

Conclusions Prevalence of penicillin and macrolide–azalide resistance among S. pneumoniae appears to be on the increase in Turkey while overall ß-lactamase production in H. influenzae remains relatively low. To adequately monitor the spread of drug-resistant phenotypes among these two important CARTI pathogens, ongoing collection of resistance surveillance data is required—where possible locally as resistance patterns can vary substantially between cities and institutions. (Source: Journal of Antimicrobial Chemotherapy)

Cefprozil(Cefprozil) Powder, For Suspension [Aurobindo Pharma Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 06 Jul 2007 05:00:00 +0100

Updated Date: Jul 6, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cefzil(Cefprozil) Tablet, Film Coated Cefzil(Cefprozil) Powder, For Suspension [Bristol-Myers Squibb]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 29 Jun 2007 05:00:00 +0100

Updated Date: Jun 29, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Oral cefprozil has good penetration into the middle ear fluid (MEF) of paediatric patients with acute otitis media

Inpharma — Fri, 27 Apr 2007 18:40:04 +0100

(Source: Inpharma)

Oral cefprozil has good penetration into the middle ear fluid (MEF) of paediatric patients with acute otitis media.

Inpharma Weekly — Sat, 21 Apr 2007 18:22:03 +0100

Page: 23 (Source: Inpharma Weekly)

Pharmacokinetics of Cefprozil in Plasma and Middle Ear Fluid: In Children Undergoing Treatment for Acute Otitis Media

Pediatric Drugs — Sun, 08 Apr 2007 01:10:05 +0100

(Source: Pediatric Drugs)

Pharmacokinetics of Cefprozil in Plasma and Middle Ear Fluid: In Children Undergoing Treatment for Acute Otitis Media.

Pediatric Drugs — Fri, 06 Apr 2007 11:54:03 +0100

Page: 119Authors: Nicolau, David P 1; Sutherland, Christina A 1; Arguedas, Adriano 2; Dagan, Ron 3; Pichichero, Micheal E 4 (Source: Pediatric Drugs)

Cefprozil: Hepatitis: case report

Reactions — Wed, 07 Mar 2007 19:55:13 +0100

(Source: Reactions)

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Cefprozil: Hepatitis: case report.

Reactions Weekly — Sat, 03 Mar 2007 08:20:09 +0100

(Source: Reactions Weekly)

Cefalexin/cefprozil: Fatal hypersensitivity myocarditis (first report with cefprozil) in children: 2 case reports

Reactions — Wed, 31 Jan 2007 10:25:03 +0100

(Source: Reactions)

Cefalexin/cefprozil: Fatal hypersensitivity myocarditis (first report with cefprozil) in children: 2 case reports.

Reactions Weekly — Sat, 27 Jan 2007 05:39:02 +0100

(Source: Reactions Weekly)

Pharmacokinetics of cefprozil in plasma and middle ear fluid: in children undergoing treatment for acute otitis media.

Paediatric Drugs — Mon, 01 Jan 2007 05:00:00 +0100

CONCLUSIONS: The plasma profile of cefprozil in the current analysis is consistent with previously reported values in children receiving the 15 mg/kg twice daily dose. MEF penetration and the duration of drug exposure at the site of infection support the clinical utility of this agent for organisms with minimum inhibitory concentrations (MIC) of < or =1 microg/mL. However, these results also predict higher clinical failure when using this dose of cefprozil against penicillin-non-susceptible Streptococcus pneumoniae or Haemophilus influenzae because of typically higher MIC values for these organisms. PMID: 17407367 [PubMed - indexed for MEDLINE] (Source: Paediatric Drugs)

Ranbaxy Is Granted Final Approval To Manufacture And Market Cefprozil Anti- Infective Tablets

Health News from Medical News Today — Fri, 15 Dec 2006 08:00:00 +0100

Ranbaxy Pharmaceuticals Inc. (RPI), a wholly owned subsidiary of Ranbaxy Laboratories Limited (RLL), announced today that RLL has received approval from the U.S. Food and Drug Administration to manufacture and market Cefprozil Tablets USP, 250 mg and 500 mg. The Office of Generic Drugs, U.S. [click link for full article] (Source: Health News from Medical News Today)

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Ranbaxy Receives Approval To Market Cefprozil Suspension

Health News from Medical News Today — Mon, 03 Jul 2006 07:00:00 +0100

Ranbaxy Pharmaceuticals Inc.(RPI), a wholly owned subsidiary of Ranbaxy Laboratories Limited (RLL),announced today that RLL has received approval from the U.S. Food and DrugAdministration to manufacture and market Cefprozil for Oral Suspension USP,125 mg/5mL and 250 mg/5mL. The Office of Generic Drugs, U.S. [click link for full article] (Source: Health News from Medical News Today)

Ranbaxy Receives Approval to Market Cefprozil Suspension

Drug Newswire — Sat, 01 Jul 2006 06:00:00 +0100

PRINCETON, N.J., June 30 /PRNewswire/ -- Ranbaxy Pharmaceuticals Inc. (RPI), a wholly owned subsidiary of Ranbaxy Laboratories Limited (RLL), announced today that RLL has received approval from the U.S. Food and Drug Administration to manufacture and market Cefprozil for Oral Suspension USP, 125 mg/5mL and 250 mg/5mL. The Office of... (Source: Drug Newswire)

Cefprozil (Cefzil) discontinued

NeLM Headline News — Wed, 21 Jun 2006 00:00:00 +0100

For commercial reasons, cefprozil (Cefzil) has been discontinued by Bristol-Myers-Squibb. For further information, please call medical information on 0800 731 1736. (Source: NeLM Headline News)

Lupin Receives US FDA Approval for Cefprozil Tablets

Drug Newswire — Sat, 20 May 2006 06:00:00 +0100

MUMBAI, India - Lupin Ltd. today announced that it has received US FDA approval for its Abbreviated New Drug Application (ANDA) for Cefprozil Tablets USP, 250 mg and 500 mg. Cefprozil is the generic equivalent of Bristol-Myers Squibb's Cefzil(R). The tablet market in the US is USD 117 million as... (Source: Drug Newswire)

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