MedWorm: Citalopram

Citalopram shown to cause QT prolongation, says Health Canada

Reactions — Sun, 05 Feb 2012 18:29:54 +0100

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Citalopram/scopolamine: Central anticholinergic syndrome: case report

Reactions — Sun, 05 Feb 2012 18:29:54 +0100

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Ciprofloxacin/citalopram interaction: Torsades de pointes in an elderly patient: case report

Reactions — Thu, 02 Feb 2012 18:34:27 +0100

(Source: Reactions)

Severity of depression and response to antidepressants: GENPOD randomised controlled trial [PAPERS]

The British Journal of Psychiatry — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions Treatment with NARIs does not confer any advantage over SSRI treatment for outcome in those with more severe depressive illness presenting in primary care. (Source: The British Journal of Psychiatry)

A case of a suicide attempt with citalopram (Celexa) causing suppression of sinusal rhythm with development of atrial rhythm - Korkmaz S, Korkmaz H, Atmaca M, Kuloðlu M.

SafetyLit: All (Unduplicated) — Mon, 30 Jan 2012 15:32:08 +0100

Selective serotonin reuptake inhibitors (SSRI) are known as effective and quite safe antidepressant drugs which inhibit serotonin reuptake in the presynaptic area without affecting the noradrenaline and dopamine reuptake. Nevertheless, in high dose use of ... (Source: SafetyLit: All (Unduplicated))

The Brown University Child and Adolescent Psychopharmacology Update — Sat, 28 Jan 2012 19:11:52 +0100

AbstractNew AACAP Practice Parameter for OCDPresence of Disruptive Behaviors With Bipolar Predicts Drug ResponsePediatric Bipolar Disorder: Aripiprazole Tested as Maintenance TreatmentLisdexamfetamine Improves ADHD Symptoms/Functioning in College StudentsExpert Recommendations on Treating Aggressive YouthHigh Antipsychotic Rates in Foster CareOpen‐Label Study of Citalopram in Hospitalized TeensNo Increased Risk of Serious Heart Disease With ADHD Drugs in Young or Older AdultsCognitive Function in Adolescent Schizophrenia Following ECTImipramine for Risperidone‐Induced EnuresisSSRIs in Pregnancy: No Change in RecommendationsRecommendations Unchanged on ADHD DrugsNew Approvals (Source: The Brown University Child and Adolescent Psychopharmacology Update)

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Citalopram: Poor neonatal adaptation syndrome following in utero exposure: case report

Reactions — Mon, 23 Jan 2012 18:35:21 +0100

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Antidepressants

Medicine — Sat, 21 Jan 2012 13:58:54 +0100

Abstract: Antidepressant drugs differ in their relative toxicities. The most hazardous are tricyclics, citalopram, venlafaxine and the rarely used monamine oxidase inhibitors. Features include arrhythmias, convulsions and cardiovascular effects. Management should be as active as necessary to reduce arrhythmia risk by aggressive correction of acidosis and use of sodium bicarbonate to shorten QRS duration if prolonged. (Source: Medicine)

Resumption of food and fluid intake in Alzheimer's disease with severe apathy following intravenous citalopram

Psychiatry and Clinical Neurosciences — Thu, 19 Jan 2012 12:22:54 +0100

(Source: Psychiatry and Clinical Neurosciences)

Citalopram: Hyperactivity in a child: case report

Reactions — Tue, 17 Jan 2012 19:08:18 +0100

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Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior.

Behavioural Brain Research — Tue, 17 Jan 2012 05:00:00 +0100

Authors: Peruga I, Hartwig S, Merkler D, Thöne J, Hovemann B, Juckel G, Gold R, Linker RA Abstract On a molecular level, depression is characterized by an altered monoaminergic neurotransmission as well as a modulation of cytokines and other mediators in the central nervous system. In particular, neurotrophic factors may influence affective behavior including depression and anxiety. Ciliary neurotrophic factor (CNTF) plays an important role in the regulation of neuronal development, neuroprotection and may also influence cognitive processes. Here we investigate the affective behavior in mice deficient for CNTF (CNTF -/- mice) at young age of 10-20 weeks. CNTF -/- mice displayed an increased anxiety-like behavior with a 30% reduction of the time spent in the bright compartment of t...

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Premenstrual syndrome and premenstrual dysphoric disorder (review)

Clinical Cases and Images — Fri, 13 Jan 2012 13:25:00 +0100

Premenstrual syndrome Premenstrual syndrome is defined as recurrent psychological and physical symptoms that occur during the luteal phase of menses and resolve with menstruation. It affects 20-30% of premenopausal women. Premenstrual dysphoric disorder Premenstrual dysphoric disorder includes affective or somatic symptoms that cause severe dysfunction in social or occupational activity. It affects 3-8% of premenopausal women. Proposed etiologies (causative factors) include: - increased sensitivity to normal cycling levels of estrogen and progesterone - increased aldosterone and plasma renin activity - neurotransmitter abnormalities, particularly serotonin The Daily Record of Severity of Problems is one tool with which women may self-report premenstrual symptoms. Symptom reli...

On the Medication Carousel

About.com Bipolar Disorder — Thu, 12 Jan 2012 05:00:00 +0100

In Part 11 of this series the bipolar patient is still depressed and medication changes are frequent. Wellbutrin - Celexa - Trazodone - Zyprexa - gosh it's a poem! (Source: About.com Bipolar Disorder)

A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia.

Brain, Behavior, and Immunity — Wed, 11 Jan 2012 05:00:00 +0100

Authors: Tynan RJ, Weidenhofer J, Hinwood M, Cairns MJ, Day TA, Walker FR Abstract Selective serotonin and serotonin norepinephrine reuptake inhibitors (SSRI; SNRI) are the first choice pharmacological treatment options for major depression. It has long been assumed that the primary therapeutic mechanism of action of these drugs involves the modulation of monoaminergic systems. However, contemporary investigations have revealed that depression is linked with inflammation, and that SSRI/SNRIs possess significant anti-inflammatory actions. While these anti-inflammatory properties initially only related to work undertaken on cells of the peripheral immune system, it has recently become apparent that these drugs also exert anti-inflammatory effects on microglia, the principal cells wit...

Blockade of the high‐affinity norepinephrine transporter (NET) by the selective serotonin reuptake inhibitor escitalopram: an in vivo microdialysis study in mice

British Journal of Pharmacology — Tue, 10 Jan 2012 05:00:00 +0100

Conclusions and implications These experiments suggest that escitalopram enhances, although moderately, cortical [NE]extin vivo by a direct mechanism involving the inhibition of the high‐affinity NE transporter (NET). (Source: British Journal of Pharmacology)

Antidepressants Increase Risk for Nursing Home Falls in Patients With Dementia

About.com Depression — Mon, 09 Jan 2012 05:00:00 +0100

Nursing home patients with dementia who were taking a class of antidepressants called serotonin reuptake inhibitors - which includes such drugs as Prozac, Paxil, Lexapro, Zoloft and Celexa - were three times more likely to experience a fall than other dementia patients, according to a new study out of the Netherlands....Read Full Post (Source: About.com Depression)

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CITALOPRAM HYDROBROMIDEtablet [International Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 06 Jan 2012 05:00:00 +0100

Updated Date: Jan 6, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Podcast: Changing FDA Recommendations on Citalopram. . Why Now?

Psychiatric Times — Fri, 30 Dec 2011 10:30:01 +0100

Have you heard the news that citalopram should no longer be used at doses greater than 40 mg? Steven Moffic, MD, explores the issues surrounding this recent recommendation. (Source: Psychiatric Times)

Podcast: Observations on FDA Recommendations for Citalopram Dosage

Psychiatric Times — Sat, 24 Dec 2011 03:00:02 +0100

A short update on the structure of drug binding sites on neurotransmitter transporters

BMC Research Notes — Thu, 22 Dec 2011 05:00:00 +0100

Conclusions: The findings presented here contribute as an update on the structure of the binding sites of DAT, NET and SERT. The updated models, which have larger ligand binding site areas than models based on other templates, may serve as improved tools for virtual ligand screening. (Source: BMC Research Notes)

Severity of depression and response to antidepressants: GENPOD randomised controlled trial

NeLM - Mental Health — Thu, 22 Dec 2011 05:00:00 +0100

Source: Br J Psychiatry Area: News Some studies have suggested that noradrenaline reuptake inhibitors (NARIs) are more effective in the more severe depressions. The GENetic and clinical Predictors Of treatment response in Depression (GENPOD) study was designed to test two primary hypotheses: 1. those with the 'l/l' genotype of 5-HTTLPR would respond better to an SSRI than a NARI 2. those with more severe depression would show better response to a NARI than a selective serotonin reuptake inhibitor (SSRI). The current paper reports the findings for the clinical predictor. The study recruited 601 individuals recruited from UK primary care who met ICD-10 criteria for a depressive episode and scored 15 or more on the Beck Depression Inventory (BDI). They were ...

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Drug-induced immune thrombocytopaenia: results from the Berlin Case–Control Surveillance Study

European Journal of Clinical Pharmacology — Tue, 20 Dec 2011 16:46:52 +0100

Conclusions Our study confirms known ITP risks for glycoprotein IIb/IIIa receptor antagonists and sulphonamides and generates signals for several other drugs and vaccines. New onset of ITP should not only direct attention to drugs as possible aetiological agents, but also to vaccines that are known to cause autoimmune phenomena. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-12DOI 10.1007/s00228-011-1184-3Authors Edeltraut Garbe, Centre of Clinical Pharmacology and Toxicology, Charité–Universitätsmedizin Berlin, Berlin, GermanyFrank Andersohn, Institute for Social Medicine, Epidemiology and Health Economy, Charité–Universitätsmedizin Berlin, Berlin, GermanyElisabeth Bronder, Centre of Clinical Pharmacology and Toxicology, C...

Citalopram: Hepatotoxicity in an elderly patient: case report

Reactions — Fri, 16 Dec 2011 06:55:18 +0100

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MHRA: New data on QT interval prolongation with citalopram and escitalopram lead to changes in dose and cautions/contraindications

NeLM - Mental Health — Tue, 13 Dec 2011 05:00:00 +0100

Source: MHRA Area: Evidence > Medication Safety The December 2011 issue of Drug Safety Update from the MHRA includes an article advising healthcare professionals of new data concerning the risk of QT interval prolongation with citalopram and escitalopram. The potential for QT citalopram and escitalopram to cause QT interval prolongation has been known for some time and is reflected in the product information. New data have however become available allowing clarification of the risks and their dose-dependency; new maximum daily dose restrictions (including in elderly patients), contraindications, and warnings have been issued as a result. The article summarises the new data and resulting recommendations for both agents - please see the link below for furthe...

CITALOPRAM (Citalopram ) Tablet, Film Coated CITALOPRAM (Citalopram Hydrobromide) Tablet, Film Coated [Apotex Corp.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 13 Dec 2011 05:00:00 +0100

Updated Date: Dec 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Massive quetiapine overdose causes delayed cardiotoxicity

The Poison Review — Sun, 11 Dec 2011 20:35:30 +0100

3.5 out of 5 stars Clinical and analytical features of severe suicidal quetiapine overdoses – a retrospective cohort study. Eyer F et al. Clin Toxicol 2011;49:846-853. Abstract Quetiapine (Seroquel) is an atypical antipsychotic agent that blocks muscarinic, α-adrenergic, histaminic, and serotonergic receptors. Major toxic manifestations include hypotension, CNS depression, tachycardia, seizures, and delirium (presumably anticholinergic. Although some literature has stated that quetiapine is relatively safe, overdose deaths have been reported. In fact, this paper point out that in Great Britain, quetiapine has been associated with the highest incidence of fatality among all the antipsychotics. This retrospective review of 20 cases of confirmed severe quetiapine overdose requiri...

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Detection of Amitriptyline, Citalopram, and Metabolites in Porcine Bones Following Extended Outdoor Decomposition*

Journal of Forensic Sciences — Thu, 08 Dec 2011 05:00:00 +0100

Authors: Desrosiers NA, Watterson JH, Dean D, Wyman JF Abstract Skeletal remains of a domestic pig were assessed for relative distribution of amitriptyline, citalopram, and metabolites. Following acute exposure and outdoor decomposition for 2 years, drugs and metabolites were analyzed in 13 different bones. Bones were pulverized following a simple wash procedure, and drugs were extracted by passive incubation in methanol, followed by solid-phase extraction. Samples were analyzed by ultra-high performance liquid chromatography (UHPLC) and confirmed with gas chromatography-mass spectrometry. The Kruskall-Wallis test showed that bone type was a main effect with respect to drug level for all analytes, with levels varying from 33- to 166-fold. Ratios of levels of drug to that of t...

CITALOPRAM HYDROBROMIDEtablet [Caraco Pharmaceutical Laboratories, Ltd.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 05 Dec 2011 05:00:00 +0100

Updated Date: Dec 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Dissociable effects of monoamine reuptake inhibitors on distinct forms of impulsive behavior in rats

Psychopharmacology — Fri, 02 Dec 2011 06:45:35 +0100

Conclusions Elevation of DA neurotransmission increases impulsive action and reduces impulsive choice. Increasing NA or 5-HT neurotransmission reduces impulsive action. Content Type Journal ArticleCategory Original InvestigationPages 1-14DOI 10.1007/s00213-011-2576-xAuthors Petra J. J. Baarendse, Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The NetherlandsLouk J. M. J. Vanderschuren, Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology)

A Double-Blind Placebo-Controlled Trial of Fluoxetine for Repetitive Behaviors and Global Severity in Adult Autism Spectrum Disorders.

The American Journal of Psychiatry — Fri, 02 Dec 2011 05:00:00 +0100

CONCLUSIONS: Fluoxetine treatment, compared to placebo, resulted in significantly greater improvement in repetitive behaviors, according to both the Yale-Brown compulsion subscale and CGI rating of obsessive-compulsive symptoms, as well as on the CGI overall improvement rating. Fluoxetine appeared to be well tolerated. These findings stand in contrast to findings in a trial of citalopram for childhood autism. PMID: 22193531 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)

Psychotherapeutic and Pharmacologic Treatment of Schizotypal Personality Disorder: The Heuristic Utility of Stressing Function Over Form

Clinical Case Studies — Thu, 01 Dec 2011 05:00:00 +0100

Although the traditional emphasis on overt symptomatology leads readily to diagnosis, such categorization typically assumes a pathological process within the individual that may at best be managed or modified. Conceptualization of symptoms in terms of adaptive and functional considerations may facilitate and broaden options for treatment, potentially improving outcome. This case study provides an example of treatment of schizotypal personality disorder using such an approach. Psychotherapy and medication were directed toward alleviating symptoms of anxiety and depression producing functional impairment in memory, and development of interpersonal skills to increase prospects for reinforcement in interaction with others was implemented to decrease the need for fantasy as a means of obtaining...

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Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test

Journal of Psychopharmacology — Thu, 01 Dec 2011 05:00:00 +0100

Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. Accordingly, nicotine enhances antidepressant-like actions of reuptake inhibitors selective for serotonin or noradrenaline in the mouse forced swim test and the mouse tail suspension test. Both high-affinity α4β2 and low-affinity α7 nicotinic acetylcholine receptor subtypes are implicated in nicotine-mediated release of serotonin and noradrenaline. The present study therefore investigated whether selective agonism of α4β2 or α7 nicotinic acetylcholine receptors would affect the mouse forced swim test activity of two antidepressants with distinct mechanisms of action, namely the selective serotonin reuptake inhibitor citalopram and the no...

Therapeutic interventions for vascular depression: a systematic review.

Revista Brasileira de Psiquiatria — Thu, 01 Dec 2011 05:00:00 +0100

CONCLUSION: VaD seems to be a useful concept for clinical interventions; however, further trials should refine CRFs criteria to assess its impact on antidepressant efficacy. PMID: 22189931 [PubMed - in process] (Source: Revista Brasileira de Psiquiatria)

Augmentation by escitalopram, but not citalopram or R‐citalopram, of the effects of low dose risperidone. Behavioral, biochemical and electrophysiological evidence

Synapse — Mon, 28 Nov 2011 05:00:00 +0100

We examined antipsychotic efficacy using the conditioned avoidance response (CAR) test, extrapyramidal side effect (EPS) liability using a catalepsy test, dopamine outflow in the medial prefrontal cortex (mPFC) and nucleus accumbens using in vivo microdialysis in freely moving animals, and NMDA receptor‐mediated transmission in the mPFC using intracellular electrophysiological recording in vitro. Only escitalopram (5 mg/kg), but not citalopram (10 mg/kg) or R‐citalopram (10 mg/kg), dramatically enhanced the antipsychotic‐like effect of a low dose of risperidone (0.25 mg/kg), without increasing catalepsy. Given alone, escitalopram, but not citalopram or R‐citalopram, markedly enhanced both cortical dopamine output and NMDA receptor‐mediated transmission. Addition of escitalopram a...

Augmentation by escitalopram, but not citalopram or R‐citalopram, of the effects of low‐dose risperidone: Behavioral, biochemical, and electrophysiological evidence

Synapse — Mon, 28 Nov 2011 05:00:00 +0100

We examined antipsychotic efficacy using the conditioned avoidance response (CAR) test, extrapyramidal side effect (EPS) liability using a catalepsy test, dopamine outflow in the medial prefrontal cortex (mPFC) and nucleus accumbens using in vivo microdialysis in freely moving animals, and NMDA receptor‐mediated transmission in the mPFC using intracellular electrophysiological recording in vitro. Only escitalopram (5 mg/kg), but not citalopram (10 mg/kg), or R‐citalopram (10 mg/kg), dramatically enhanced the antipsychotic‐like effect of a low dose of risperidone (0.25 mg/kg), without increasing catalepsy. Given alone, escitalopram, but not citalopram or R‐citalopram, markedly enhanced both cortical dopamine output and NMDA receptor‐mediated transmission. Addition of escitalopram ...

Problem-based review: paracetamol overdose. - Heaps T.

SafetyLit: All (Unduplicated) — Sat, 26 Nov 2011 00:42:13 +0100

A 29-year old male presents to the emergency department 1h after an overdose of cocodamol. He admits to taking approximately 60 x 8/500mg tablets, with alcohol, over a 20 minute period. He has a past history of depression, treated by his GP with citalopram... (Source: SafetyLit: All (Unduplicated))

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The importance of drug–drug interactions as a cause of adverse drug reactions: a pharmacovigilance study of serotoninergic reuptake inhibitors in France

European Journal of Clinical Pharmacology — Thu, 24 Nov 2011 17:49:50 +0100

Conclusion Around 40% of ADRs reported with SRIs were related to DDIs. Most of these occurred after association with psychotropics, antithrombotics, or diuretics, especially in the elderly. Content Type Journal ArticleCategory Pharmacoepidemiology and PrescriptionPages 1-9DOI 10.1007/s00228-011-1156-7Authors Francois Montastruc, Laboratoire de Pharmacologie Médicale et Clinique, UMR-INSERM U1027, Equipe de Pharmacoépidémiologie, Faculté de Médecine, Université de Toulouse, 37 allées Jules-Guesde, 31000 Toulouse, FranceAgnès Sommet, Laboratoire de Pharmacologie Médicale et Clinique, UMR-INSERM U1027, Equipe de Pharmacoépidémiologie, Faculté de Médecine, Université de Toulouse, 37 allées Jules-Guesde, 31000 Toulouse, FranceEmmanuelle Bondon-Guitton, Labo...

CELEXA (Citalopram Hydrobromide) Tablet, Film Coated [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Nov 2011 05:00:00 +0100

Updated Date: Nov 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CITALOPRAM (Citalopram) Tablet [H.J. Harkins Company, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 18 Nov 2011 05:00:00 +0100

Updated Date: Nov 18, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

TGA advises of dosing change for citalopram

Reactions — Wed, 16 Nov 2011 21:59:42 +0100

(Source: Reactions)

Citalopram/zopiclone: Various toxicities: case report

Reactions — Wed, 16 Nov 2011 21:59:42 +0100

(Source: Reactions)

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Celexa / Citalopram Maximum Dosage Cut from 60 to 40mg - What Will That Mean to You?

About.com Bipolar Disorder — Sun, 13 Nov 2011 15:38:28 +0100

Back in August I wrote about the FDA's warning to reduce the maximum dose of Celexa - generic citalopram - because the higher dose has been associated with heart rhythm problems. My readers have been discussing the issue and asking questions about how it will affect them and their loved ones. Emma says citalopram is doing very well to control her anxiety and intrusive thoughts at 60mg. Dropping the dose to 40mg, she wrote, will be "a 30% reduction in my antidepressant, and I have no idea how this is going to affect me." Korey mentioned that heart issues run strongly in her mother's family so she is really worried that her mom and sister take 60mg. "I'm glad they're gonna talk to their doctors about it," she said. One of the dangers of reducing the dosage of Celexa or citalopram is that ...

Outcomes on the pharmacopsychometric triangle in bupropion‐SR vs. buspirone augmentation of citalopram in the STAR*D trial

Acta Psychiatrica Scandinavica — Sat, 12 Nov 2011 05:00:00 +0100

Conclusion: In all domains of the pharmacopsychometric triangle, bupropion‐SR was superior to buspirone as augmentation therapy in depressed outpatients not responding to citalopram. (Source: Acta Psychiatrica Scandinavica)

Health Canada is reviewing the heart-related safety of citalopram

Reactions — Thu, 10 Nov 2011 08:03:53 +0100

(Source: Reactions)

CITALOPRAM HYDROBROMIDEtablet [PD-Rx Pharmaceuticals, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 10 Nov 2011 05:00:00 +0100

Updated Date: Nov 10, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Perinatal antidepressant exposure alters cortical network function in rodents [Neuroscience]

Proceedings of the National Academy of Sciences — Tue, 08 Nov 2011 05:00:00 +0100

Serotonin (5-HT) plays a key role in early brain development, and manipulation of 5-HT levels during this period can have lasting neurobiological and behavioral consequences. It is unclear how perinatal exposure to drugs, such as selective serotonin reuptake inhibitors (SSRIs), impacts cortical neural network function and what mechanism(s) may elicit the disruption of normal neuronal connections/interactions. In this article, we report on cortical wiring organization after pre- and postnatal exposure to the SSRI citalopram. We show that manipulation of 5-HT during early development in both in vitro and in vivo models disturbs characteristic chemoarchitectural and electrophysiological brain features, including changes in raphe and callosal connections, sensory processing, and myelin sheath ...

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Lundbeck communication on link between citalopram (Cipramil) and dose dependent QT interval prolongation

NeLM - Mental Health — Fri, 04 Nov 2011 04:00:00 +0100

Source: Lundbeck Limited (UK), MHRA Area: Evidence > Medication Safety Lundbeck Limited (UK) in collaboration with the MHRA has issued a letter to inform healthcare professionals of important new recommendations for the use of Cipramil (citalopram hydrobromide; also marketed as generic formulations). This follows an assessment of a QT study that has shown a dose dependent increase in the QT interval observed with ECG monitoring, and also a review of spontaneous reports of cases of QT prolongation and ventricular arrhythmia including Torsade de Pointes. In addition, further studies have not shown an added benefit in the treatment of depression at doses higher than 40mg daily. Recommendations include the following: . The maximum dose of citalopram is now 40mg ...

Neonatal Citalopram Treatment Inhibits the 5-HT Depleting Effects of MDMA Exposure in Rats

ACS Chemical Neuroscience — Wed, 02 Nov 2011 05:51:27 +0100

ACS Chemical NeuroscienceDOI: 10.1021/cn2000553 (Source: ACS Chemical Neuroscience)

Effect of chronic variable stress on corticosterone levels and hippocampal extracellular 5‐HT in rats with persistent differences in positive affectivity

Acta Neuropsychiatrica — Tue, 01 Nov 2011 04:00:00 +0100

Conclusion: Chronic stress appears to modify hippocampal 5‐HT overflow in rats with low positive affectivity. This finding supports the notion of greater vulnerability to CVS in male rats with low positive affectivity. (Source: Acta Neuropsychiatrica)

A review of escitalopram and citalopram in child and adolescent depression.

Journal of the Canadian Academy of Child and Adolescent Psychiatry — Tue, 01 Nov 2011 04:00:00 +0100

CONCLUSION: At present, escitalopram and citalopram should be considered a second-line option for adolescent depression. The US Food and Drug Administration approval of escitalopram for treatment of adolescent depression was based on a single positive RCT. This is less evidence than typically required for approval of a drug for a new indication. PMID: 22114615 [PubMed - in process] (Source: Journal of the Canadian Academy of Child and Adolescent Psychiatry)

Antidepressant Linked to Autistic Behavior

About.com Depression — Fri, 28 Oct 2011 04:00:00 +0100

According to researchers at the University of Mississippi Medical Center and the University of California, San Francisco, rats exposed to the antidepressant citalopram (Celexa) as fetuses and just after birth showed behaviors similar to autism....Read Full Post (Source: About.com Depression)

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Tamoxifen/paroxetine/citalopram interaction: Hot flashes and first report of an interaction, leading to altered tamoxifen metabolite concentrations: case report

Reactions — Wed, 26 Oct 2011 13:05:18 +0100

(Source: Reactions)

Brain Development In Rats Stunted By Perinatal Antidepressant

Health News from Medical News Today — Wed, 26 Oct 2011 07:00:00 +0100

Rats exposed to an antidepressant just before and after birth showed substantial brain abnormalities and behaviors, in a study funded by the National Institutes of Health. After receiving citalopram, a serotonin-selective reuptake inhibitor (SSRI), during this critical period, long-distance connections between the two hemispheres of the brain showed stunted growth and degeneration. The animals also became excessively fearful when faced with new situations and failed to play normally with peers - behaviors reminiscent of novelty avoidance and social impairments seen in autism... (Source: Health News from Medical News Today)

Perinatal antidepressant stunts brain development in rats

EurekAlert! - Social and Behavioral Science — Mon, 24 Oct 2011 04:00:00 +0100

(NIH/National Institute of Mental Health) Rats exposed to an antidepressant just before and after birth showed substantial brain abnormalities and behaviors, in a study funded by the National Institutes of Health. After receiving citalopram, a serotonin-selective reuptake inhibitor, during this critical period, long-distance connections between the two hemispheres of the brain showed stunted growth and degeneration. The animals also became excessively fearful when faced with new situations and failed to play normally with peers. (Source: EurekAlert! - Social and Behavioral Science)

FDA warns about linezolid, methylene blue association with serotonin syndrome

The Poison Review — Sat, 22 Oct 2011 04:44:48 +0100

The U.S. Food and Drug Administration issued Safety Announcements yesterday to update the public and medical practitioner on potential drug interactions between serotonergic psychiatric medications and either the antibiotic linezolid (Zyvox) or methylene blue. Both of these drugs act as monoamine oxidase inhibitors, and can cause CNS toxicity and serotonin syndrome in patients taking selective serotonin reuptake inhibitors (SSRI), selective norepinephrine inhibitors (SNRI), or certain tricyclic antidepressants such as clomipramine. The announcement notes that most cases of serotonin syndrome associated with methylene blue have occurred in the context of parathyroid surgery, where relatively high doses of the dye are injected intravenously to allow better visualization of the parathyroid g...

Depression in children and adolescents

Clinical Evidence — Fri, 21 Oct 2011 23:00:00 +0100

New evidence; conclusion confirmed for: Fluoxetine New evidence added. Categorisation unchanged (Beneficial). Citalopram/escitalopram in children and adolescents New evidence added. Categorisation unchanged (Unknown effectiveness) because evidence remains insufficient to judge the effects of this intervention. Fluvoxamine in children and adolescents New evidence added on harms only. Categorisation unchanged (Unknown effectiveness) because evidence remains insufficient to judge the effects of this intervention. Paroxetine in children and adolescents New evidence added on harms only. Categorisation unchanged (Unlikely to be beneficial). ...

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Premenstrual syndrome and premenstrual dysphoric disorder.

American Family Physician — Sat, 15 Oct 2011 04:00:00 +0100

Authors: Biggs WS, Demuth RH Abstract Premenstrual syndrome is defined as recurrent moderate psychological and physical symptoms that occur during the luteal phase of menses and resolve with menstruation. It affects 20 to 32 percent of premenopausal women. Women with premenstrual dysphoric disorder experience affective or somatic symptoms that cause severe dysfunction in social or occupational realms. The disorder affects 3 to 8 percent of premenopausal women. Proposed etiologies include increased sensitivity to normal cycling levels of estrogen and progesterone, increased aldosterone and plasma renin activity, and neurotransmitter abnormalities, particularly serotonin. The Daily Record of Severity of Problems is one tool with which women may self-report the presence and severity o...

Health Canada reviewing antidepressant Celexa

CTV Health — Fri, 14 Oct 2011 11:10:30 +0100

Health Canada says it is reviewing the antidepressant citalopram after a new study suggested high doses -- 60 milligrams a day -- can affect the electrical activity of the heart. (Source: CTV Health)

Correlation of QTc Interval Prolongation and Serum Level of Citalopram after Intoxication – A Case Report

Pharmacopsychiatry — Wed, 12 Oct 2011 04:00:00 +0100

We report the case of a 46-year-old woman, who ingested in suicidal intention 1400 mg CIT. During the following inpatient treatment repeatedly ECGs and determinations of the serum level of CIT were performed. Initially the patient’s serum level of CIT was 1231 ng/mL and QTc interval was 541.60 ms. It took 12 days until the serum level of CIT fell below the upper threshold of the recommended therapeutic range (130 ng/mL). The QTc interval on the sixth day after the intoxication for the first time was below 500 ms. The QTc interval correlated significantly with the serum level of CIT after intoxication (r=0.943; p<0.005). Although CIT is estimated as a safe antidepressant regarding serious adverse effects, toxic doses can lead to potentially hazardous ECG changes which accordi...

The Brown University Psychopharmacology Update — Sat, 08 Oct 2011 12:04:03 +0100

AbstractAtypical Antipsychotics and Worsening Cognitive Function in Alzheimer's PatientsUpdated Consensus Statement on Antidementia Drugs in Clinical PracticeAripiprazole and FluoxetineNo Significant Effects of Adjunctive Risperidone for SRI‐Resistant, Combat‐Related PTSDCardiac Risks with Citalopram: Now What Do We Do?Long‐Term ADHD Drug TreatmentFew Benefits of Sertraline or Mirtazapine for Depression in Alzheimer's PatientsChanges in Sleep Quality during ADHD Stimulant TherapyHigher Rates of Nightly Bed‐Wetting with ClozapineManic Relapse in Bipolar Affective Disorder Associated with VareniclineNew WarningsSafety Labeling Changes (Source: The Brown University Psychopharmacology Update)

What Citalopram Tells Us About Prescribing Practices

Psychiatric Times — Fri, 07 Oct 2011 12:00:00 +0100

With all the justifiable concerns about our next DSM, I frankly have more concerns about treatment. After all, diagnosing is really most important as far as it leads to the necessary treatment to help the patient. (Source: Psychiatric Times)

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CITALOPRAM HYDROBROMIDEtablet, Film Coated [Forest Laboratories, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 07 Oct 2011 05:00:00 +0100

Updated Date: Oct 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CITALOPRAM HYDROBROMIDEtablet [International Labs, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 07 Oct 2011 05:00:00 +0100

Updated Date: Oct 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

NHS pays millions of pounds more than it needs to for antidepressant drugs

NeLM - News — Wed, 05 Oct 2011 04:00:00 +0100

Source: The Independent Area: News The Independent has reported that an investigation carried out by the Bureau of Investigative Journalism (BIJ) has concluded that the NHS is spending almost £25m a year on supplies of escitalopram, despite evidence that it has little clinical advantage over citalopram, which costs a fraction of the price. The article discusses how pharmaceutical companies extend the lives of drugs whose patents are about to expire, and highlights that there has only ever been one study which compared the effectiveness of citalopram vs. escitalopram (which showed escitalopram was clinically more effective compared to citalopram). The investigation also highlights connections between employees of Lundbeck, the Danish company which makes both citalopram and esci...

Citalopram/escitalopram: Gastro-oesophageal reflux disease (first report with escitalopram): case report

Reactions — Mon, 03 Oct 2011 06:00:13 +0100

(Source: Reactions)

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Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.

Epilepsy and Behaviour — Thu, 29 Sep 2011 04:00:00 +0100

Authors: Vermoesen K, Serruys AS, Loyens E, Afrikanova T, Massie A, Schallier A, Michotte Y, Crawford AD, Esguerra CV, de Witte PA, Smolders I, Clinckers R Abstract In the past, antidepressants have been thought to possess proconvulsant properties. This assumption remains controversial, however, because anticonvulsant effects have been attributed to certain antidepressants. To date, it remains unclear which antidepressants can be used for the treatment of patients with epilepsy with depression. The present study was designed to determine the anticonvulsant and/or proconvulsant effects of three antidepressants (citalopram, reboxetine, bupropion) against pilocarpine- and pentylenetetrazole-induced acute seizures in larval zebrafish and mice. In zebrafish, all antidepressants were ant...

CITALOPRAM HYDROBROMIDEtablet [Torrent Pharmaceuticals Limited]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 28 Sep 2011 05:00:00 +0100

Updated Date: Sep 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The antidepressant citalopram inhibits delayed rectifier outward K+ current in mouse cortical neurons

Journal of Neuroscience Research — Sat, 24 Sep 2011 00:31:41 +0100

We examined the effects of citalopram on delayed rectifier outward K+ current (IK) in mouse cortical neurons. Extracellular citalopram reversibly inhibited IK in a dose‐dependent manner and significantly shifted both steady‐state activation and inactivation curves toward hyperpolarization. Neither 5‐HT itself nor antagonists of 5‐HT and dopamine receptors could abolish citalopram‐induced inhibition of IK. In addition, intracellular application of GTPγ‐S similarly failed to prevent the inhibition of IK by citalopram. When applied intracellularly, citalopram had no effect on IK and did not influence the reduction of IK induced by extracellular citalopram. The effect of citalopram was use dependent, but not frequency dependent, and it did not require channel opening. Electrophysi...

Citalopram/fluorouracil: Sinus bradycardia: case report

Reactions — Thu, 22 Sep 2011 07:55:36 +0100

(Source: Reactions)

Systematic review and meta-analysis of published placebo controlled trials of citalopram for major depressive disorder in adults

NeLM - Mental Health — Thu, 22 Sep 2011 04:00:00 +0100

Source: BMJ Open Area: News The effectiveness of citalopram for major depressive disorder (MDD) in adults has been assessed in a systematic review of all published, randomised, double-blind placebo controlled studies. Studies with medically ill or treatment resistant subjects were excluded, as were studies of relapse prevention. The primary outcome was remission of MDD and response or change from baseline scores were secondary outcomes. These were measured using scores on the Hamilton Depression Scale, the Montgomery-Asberg Depression Rating Scale and Clinical Global Impressions-Severity scales. Overall 8 studies (n=2025) met the inclusion criteria and the following findings were reported: . Two studies provided data on remission, but only one of these showed a...

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Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms.

Psychological Medicine — Tue, 20 Sep 2011 04:00:00 +0100

CONCLUSIONS: Loss of interest, diminished activity and inability to make decisions predict poor outcome of antidepressant treatment even after adjustment for overall depression severity and other clinical covariates. The prominence of such symptoms may require additional treatment strategies and should be accounted for in future investigations of antidepressant response. PMID: 21929846 [PubMed - as supplied by publisher] (Source: Psychological Medicine)

[Interactions between metoprolol and antidepressants].

Tidsskrift for den Norske Laegeforening — Tue, 20 Sep 2011 04:00:00 +0100

Conclusion. Metoprolol should not be used concomitantly with paroxetine, fluoxetine or bupropion due to extensive interactions and the risk of serious adverse effects. Dose reductions of metoprolol should be considered for combined treatment with citalopram, escitalopram or duloxetine, while concurrent use with sertraline, venlafaxine, mianserin and mirtazapine should be safe. PMID: 21946596 [PubMed - in process] (Source: Tidsskrift for den Norske Laegeforening)

Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action

Psychopharmacology — Thu, 08 Sep 2011 05:52:41 +0100

Conclusions The findings from binding, neurochemical, and neurophysiological studies may provide a mechanistic rationale for the clinical difference observed with escitalopram compared to other antidepressant therapies. Content Type Journal ArticleCategory ReviewPages 1-13DOI 10.1007/s00213-011-2463-5Authors Huailing Zhong, U-Pharm Laboratories LLC, 239 New Road, Suite A-107, Parsippany, NJ 07054, USANasser Haddjeri, Laboratory of Neuropharmacology, University Claude Bernard Lyon 1, 8 Ave Rockfeller, Lyon, 69373 FranceConnie Sánchez, External Sourcing, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology)

CITALOPRAM HYDROBROMIDEtablet [St Marys Medical Park Pharmacy]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 08 Sep 2011 05:00:00 +0100

Updated Date: Sep 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Neonatal Exposure of Rats to Antidepressants Affects Behavioral Reactions to Novelty and Social Interactions in a Manner Analogous to Autistic Spectrum Disorders

Thu, 08 Sep 2011 04:00:00 +0100

AbstractWe have demonstrated that neonatal exposure to selective serotonin reuptake inhibitors has lasting effects on behavior and serotonergic neurons in Long Evans rats. Hyperserotoninemia and altered sensory processing are reported in autistic spectrum disorders (ASD). We hypothesized that early life exposure to SSRIs alters sensory processing, disrupts responses to novelty, and impairs social interactions in a manner similar to that observed in ASD. Male and female Long‐Evans rat pups were administered citalopram, buproprion, fluoxetine, or saline from postnatal day (P) 8–21. Rats were tested for response to a novel tone before weaning (P25). Later, rats were tested 2× for response to a novel object (P39), and to a novel conspecific (P78, P101). In addition, rats were assessed for...

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Altered Expression of Tyrosine Hydroxylase in the Locus Coeruleus Noradrenergic System in Citalopram Neonatally Exposed Rats and Monoamine Oxidase A Knock Out Mice

Thu, 08 Sep 2011 04:00:00 +0100

In this study, we performed double and/or triple immunofluorescent staining using antibodies against TH, DBH, and/or norepinephrine transporter (NET) to investigate the altered NE TH expression of cortical fibers in citalopram (CTM)‐exposed rats and monoamine oxidase (MAO) A knock out (KO) mice. We have noted the following novel findings: (1) neonatal exposure to the selective serotonin reuptake inhibitor (SSRI) CTM enhanced NE TH immunoreactive fibers throughout the entire neocortex, and a few of them appeared to be hypertrophic; (2) slightly enhanced NE cortical TH immunoreactive fibers were also noted in MAO A KO mice, and many of them revealed varicosities compared with the rather smooth NE cortical TH immunoreactive fibers in wild‐type (WT) mice; (3) LC dendrites of MAO A KO mice ...

Neonatal Exposure of Rats to Antidepressants Affects Behavioral Reactions to Novelty and Social Interactions in a Manner Analogous to Autistic Spectrum Disorders.

Anatomical Record — Thu, 08 Sep 2011 04:00:00 +0100

Authors: Rodriguez-Porcel F, Green D, Khatri N, Harris SS, May WL, Lin RC, Paul IA Abstract We have demonstrated that neonatal exposure to selective serotonin reuptake inhibitors has lasting effects on behavior and serotonergic neurons in Long Evans rats. Hyperserotoninemia and altered sensory processing are reported in autistic spectrum disorders (ASD). We hypothesized that early life exposure to SSRIs alters sensory processing, disrupts responses to novelty, and impairs social interactions in a manner similar to that observed in ASD. Male and female Long-Evans rat pups were administered citalopram, buproprion, fluoxetine, or saline from postnatal day (P) 8-21. Rats were tested for response to a novel tone before weaning (P25). Later, rats were tested 2× for response to a novel o...

Altered Expression of Tyrosine Hydroxylase in the Locus Coeruleus Noradrenergic System in Citalopram Neonatally Exposed Rats and Monoamine Oxidase A Knock Out Mice.

Anatomical Record — Thu, 08 Sep 2011 04:00:00 +0100

In this study, we performed double and/or triple immunofluorescent staining using antibodies against TH, DBH, and/or norepinephrine transporter (NET) to investigate the altered NE TH expression of cortical fibers in citalopram (CTM)-exposed rats and monoamine oxidase (MAO) A knock out (KO) mice. We have noted the following novel findings: (1) neonatal exposure to the selective serotonin reuptake inhibitor (SSRI) CTM enhanced NE TH immunoreactive fibers throughout the entire neocortex, and a few of them appeared to be hypertrophic; (2) slightly enhanced NE cortical TH immunoreactive fibers were also noted in MAO A KO mice, and many of them revealed varicosities compared with the rather smooth NE cortical TH immunoreactive fibers in wild-type (WT) mice; (3) LC dendrites of MAO A KO mice exhi...

Serotonin signaling is associated with lower amyloid-{beta} levels and plaques in transgenic mice and humans [Neuroscience]

Proceedings of the National Academy of Sciences — Tue, 06 Sep 2011 04:00:00 +0100

Aggregation of amyloid-β (Aβ) as toxic oligomers and amyloid plaques within the brain appears to be the pathogenic event that initiates Alzheimer's disease (AD) lesions. One therapeutic strategy has been to reduce Aβ levels to limit its accumulation. Activation of certain neurotransmitter receptors can regulate Aβ metabolism. We assessed the ability of serotonin signaling to alter brain Aβ levels and plaques in a mouse model of AD and in humans. In mice, brain interstitial fluid (ISF) Aβ levels were decreased by 25% following administration of several selective serotonin reuptake inhibitor (SSRI) antidepressant drugs. Similarly, direct infusion of serotonin into the hippocampus reduced ISF Aβ levels. Serotonin-dependent reductions in Aβ were reversed if mice were pretreated with in...

Myoclonus associated with long-term use of diltiazem.

American Journal of Health-System Pharmacy : AJHP — Tue, 06 Sep 2011 00:00:34 +0100

Conclusion A 61-year-old man developed myoclonus three years after starting diltiazem therapy for PVCs. The symptoms gradually resolved after the discontinuation of diltiazem but did not stop completely. PMID: 21880885 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

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FDA warns of dose-dependent QT prolongation with citalopram

Reactions — Sun, 04 Sep 2011 16:16:09 +0100

(Source: Reactions)

FDA approves Xalkori with companion diagnostic for a type of late-stage lung cancer

Modern Medicine — Thu, 01 Sep 2011 23:00:00 +0100

FDA has notified healthcare professionals and patients that the antidepressant citalopram hydrobromide (Celexa, Forest Laboratories) should no longer be used at doses greater than 40 mg per day because it can cause abnormal changes in the electrical activity of the heart. (Source: Modern Medicine)

Digest

Progress in Neurology and Psychiatry — Thu, 01 Sep 2011 04:00:00 +0100

AbstractNewsNICE guideline on ADHDConsultation on the NICE guideline on ADHD (CG72) has now ended. The scheduled review will consider new evidence on diagnosis, management and the organisation of care emerging since the guideline was published in 2008. New clinical trials confirm current recommendations for the treatment of children, NICE says, and support the use of methylphenidate as firstline therapy in adults followed by atomoxetine or dexamfetamine for patients who do not respond to or who are intolerant of six weeks' treatment with methylphenidate.NICE stroke recommendationsAbout half of patients with suspected stroke are initially managed in line with NICE's recommendations, according to an audit by the Royal College of Physicians (www.rcplondon.ac.uk). The College's Stroke Improvem...

Citalopram: Seizures: case report

Reactions — Mon, 29 Aug 2011 14:09:06 +0100

(Source: Reactions)

Citalopram/tramadol: Serotonin syndrome in an elderly patient: case report

Reactions — Mon, 29 Aug 2011 14:09:06 +0100

(Source: Reactions)

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CELEXA (Citalopram Hydrobromide) Tablet, Film Coated CELEXA (Citalopram Hydrobromide) Suspension [Forest Laboratories, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 29 Aug 2011 05:00:00 +0100

Updated Date: Aug 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FDA Warns on Arrhythmia with High-Dose Citalopram

Physician's First Watch current issue — Sun, 28 Aug 2011 23:00:00 +0100

(Source: Physician's First Watch current issue)

Birth Defects Attorneys at The Onder Law Firm Clarify Celexa and...

PRWeb: Medical Pharmaceuticals — Sat, 27 Aug 2011 20:16:43 +0100

Celexa and Lexapro Birth Defect Lawsuits Are an Option for Children Born with Birth Defects After the Mother Took the Antidepressant During Pregnancy and Gave Birth in 1991 or Later(PRWeb August 24, 2011)Read the full story at http://www.prweb.com/releases/lexapro/lawsuit/prweb8744698.htm (Source: PRWeb: Medical Pharmaceuticals)

Cimetidine/citalopram/topiramate interaction: Serotonin toxicity in elderly patients (first report of an interaction between citalopram and cimetidine): 2 case reports

Reactions — Sat, 27 Aug 2011 15:26:04 +0100

(Source: Reactions)

Serotonergic Function and Treatment of Behavioral and Psychological Symptoms of Frontotemporal Dementia.

Am J Geriatr Psychia... — Fri, 26 Aug 2011 23:00:00 +0100

CONCLUSIONS:: The results suggest that despite the endogenous serotonin deficiency of FTD, citalopram treatment may be effective in targeting the behavioral disturbances characteristic of FTD. PMID: 21878805 [PubMed - as supplied by publisher] (Source: Am J Geriatr Psychia...)

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FDA Urges Lowering Maximum Daily Dose Of Celexa

WDSU.com - Health — Fri, 26 Aug 2011 00:45:27 +0100

The Food and Drug Administration is recommending that patients taking the anti-depressant Celexa (citalopram hydrobromide) take no more than 40mg a day. (Source: WDSU.com - Health)

Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal

British Journal of Clinical Pharmacology — Thu, 25 Aug 2011 23:00:00 +0100

Conclusions: There was a dose‐related lengthening of the QT interval that lagged the increase in drug concentration. SDAC resulted in a moderate reduction in fraction of escitalopram absorbed and reduced the risk of the QT interval being abnormal. (Source: British Journal of Clinical Pharmacology)

High Doses of Citalopram Linked to Abnormal Heart Rhythms

AAFP Health of the Public — Thu, 25 Aug 2011 21:10:00 +0100

The FDA is informing health care professionals and patients that the antidepressant citalopram hydrobromide, which is marketed as Celexa, should no longer be used at doses greater than 40 mg per day because higher doses of the drug cause QT interval prolongation that can lead to development of torsades de pointes, a potentially fatal abnormal heart rhythm. (Source: AAFP Health of the Public)

FDA Warns of Celexa Heart Risk

eMedicineHealth.com — Thu, 25 Aug 2011 07:00:00 +0100

(Source: eMedicineHealth.com)

Celexa (citalopram Hydrobromide) At Over 40mg Per Day Linked To Abnormal Heart Rhythm Risk, Warns FDA

Health News from Medical News Today — Thu, 25 Aug 2011 00:00:00 +0100

Citalopram hydrobromide, known under brand name Celexa, should not be administered at doses over 40 mg per day, because it can trigger abnormal electrical activity in the heart, leading to potentially fatal heart rhythm problems (including Torsade de Pointes), the FDA (Food and Drug Administration) announced today. The Agency added that doses above 40mg per day do not benefit in the treatment of depression. A citalopram drug label used to state that some patients may need 60 mg per day... (Source: Health News from Medical News Today)

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FDA restricts maximum daily dose of citalopram to 40mg following concerns about abnormal heart rhythms

NeLM - Mental Health — Wed, 24 Aug 2011 23:00:00 +0100

Source: FDA Area: News The FDA has notified healthcare professionals and patients in the US that citalopram should no longer be used at doses greater than 40 mg per day because it can cause abnormal changes in the electrical activity of the heart (prolongation QT interval), which can be fatal. Patients at particular risk include those with underlying heart conditions and those who are predisposed to low serum levels of potassium and magnesium. The Agency adds that studies have not shown a benefit in the treatment of depression at doses higher than 40 mg per day, though the the US drug label had stated that certain patients may require a dose of 60 mg per day. The citalopram drug label has been revised to include the new drug dosage and usage recommendations, as well as information about t...

FDA Safety Alert: Abnormal heart rhythms associated with high doses of citalopram hydrobromide

Drug Topics - Top News — Wed, 24 Aug 2011 23:00:00 +0100

FDA warns of heart risks with high doses of Celexa

USATODAY.com Health — Wed, 24 Aug 2011 22:11:47 +0100

Federal health regulators are warning doctors not to prescribe high doses of the antidepressant Celexa, because of the risk of fatal heart c ... (Source: USATODAY.com Health)

FDA Warns of Celexa Heart Risk

WebMD Health — Wed, 24 Aug 2011 17:05:00 +0100

FDA: The antidepressant Celexa should be taken at doses no higher than 40 milligrams per day because of the risk of potentially fatal changes to the heart's electrical activity. (Source: WebMD Health)

Antidepressant Tied to Dangerous Heart Rhythm, FDA Says

The Doctors Lounge - Psychiatry — Wed, 24 Aug 2011 17:00:00 +0100

Patients should not use doses of the popular drug Celexa exceeding 40 milligrams (Source: The Doctors Lounge - Psychiatry)

FDA Warns Against High-Dose Citalopram

MedPage Today Psychiatry — Wed, 24 Aug 2011 16:12:14 +0100

(MedPage Today) -- Citing increased risk of cardiac arrhythmias and a lack of therapeutic benefit associated with high doses of the SSRI citalopram hydrobromide (Celexa), the FDA has reduced the recommended maximum to 40 mg/day. (Source: MedPage Today Psychiatry)

Antidepressant Tied to Dangerous Heart Rhythm

MedlinePlus Health News — Wed, 24 Aug 2011 16:00:00 +0100

Patients should not use doses of the popular drug Celexa exceeding 40 milligrams Source: HealthDay Related MedlinePlus Pages: Antidepressants, Arrhythmia, Drug Safety (Source: MedlinePlus Health News)

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Celexa (citalopram hydrobromide): Drug Safety Communication - Abnormal Heart Rhythms Associated With High Doses

Drugs.com - Pharma News — Wed, 24 Aug 2011 15:08:03 +0100

AUDIENCE: Psychiatry, Cardiology ISSUE: FDA notified healthcare professionals and patients that the antidepressant Celexa (citalopram hydrobromide) should no longer be used at doses greater than 40 mg per day because it can cause abnormal... (Source: Drugs.com - Pharma News)

High Doses of SSRI Linked to Abnormal Heart RhythmHigh Doses of SSRI Linked to Abnormal Heart Rhythm

Medscape Today Headlines — Wed, 24 Aug 2011 15:03:49 +0100

The SSRI citalopram should not be used in doses higher than 40 mg/day because of concerns that it may cause abnormal and potentially fatal changes in heart rhythm. Medscape Medical News (Source: Medscape Today Headlines)

Celexa (citalopram hydrobromide): Drug Safety Communication - Abnormal Heart Rhythms Associated With High Doses

FDA MedWatch — Wed, 24 Aug 2011 13:46:00 +0100

Citalopram should no longer be prescribed at doses greater than 40 mg per day. (Source: FDA MedWatch)

CITALOPRAM (Citalopram Hydrobromide) Tablet, Film Coated [RedPharm Drug Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 24 Aug 2011 05:00:00 +0100

Updated Date: Aug 24, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Celexa (citalopram hydrobromide): Drug Safety Communication - Abnormal Heart Rhythms Associated With High Doses

Drugs.com - FDA MedWatch Alerts — Wed, 24 Aug 2011 04:00:00 +0100

Audience: Psychiatry, Cardiology ISSUE: FDA notified healthcare professionals and patients that the antidepressant Celexa (citalopram hydrobromide) should no longer be used at doses greater than 40 mg per day because it can cause abnormal changes in... (Source: Drugs.com - FDA MedWatch Alerts)

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Celexa Warning

About.com Depression — Mon, 22 Aug 2011 23:00:00 +0100

High doses of the antidepressant Celexa (citalopram) can causes changes in the electrical activity of the heart, leading to abnormal heart rhythms, the U.S. Food and Drug Administration announced on August 24, 2011....Read Full Post (Source: About.com Depression)

Med Sci Monit 2011; 17(9):RA205-214 "Serotonin reuptake inhibitor antidepressants (SSRIs) against atherosclerosis"

Medical Science Monitor — Mon, 22 Aug 2011 10:16:00 +0100

Selective serotonin reuptake inhibitors (SSRIs) are a class of drug widely used for treatment of mood disorders, including depression and cardiovascular disease. A search for related articles in the PubMed database was attempted. It covered studies, reports, reviews and editorials of the last 5 years. Pro-inflammatory cytokines, such as TNF-α, IL-1 and IL-6, stimulate central serotonin (5-HT) neurotransmission and are over-expressed in depression, which has been linked with hypothalamic-pituitary-adrenal axis (HPA) hyperactivity. They have also been implicated in the pathogenesis and progression of other stress-induced disorders, like myocardial infarction (MI) and coronary heart disease (CHD), as they seem to modulate cardiovascular function by a variety of mechanisms. Biological mech...

Antidepressant may cause abnormal heart rhythms

Pharmacy Europe — Mon, 22 Aug 2011 09:40:00 +0100

Celexa (citalopram hydrobromide) should be given as 40mg dose only, says FDA (Source: Pharmacy Europe)

Psychosocial interventions for premature ejaculation.

Cochrane Database of Systematic Reviews — Sat, 20 Aug 2011 17:00:05 +0100

CONCLUSIONS: Overall, there is weak and inconsistent evidence regarding the effectiveness of psychological interventions for the treatment of premature ejaculation. Three of the four included randomised controlled studies of psychotherapy for PE reported our primary outcome (Improvement in IELT), and the majority have a small sample size. The early success reports (97.8%) of Masters and Johnson could not be replicated. One study found a significant improvement from baseline in the duration of intercourse, sexual satisfaction and sexual function with a new functional-sexological treatment and behavior therapy compared to waiting list. One study showed that the combination of chlorpromazine and BT was superior to chlorpromazine alone. Randomised trials with larger group samples are still nee...

High-dose citalopram for cocaine dependence in veteran population-a pilot project.

American Journal on Addictions — Sat, 20 Aug 2011 02:50:19 +0100

Authors: Vayalapalli S, Vaughn M, Salles-Shahid K, Byrd-Sellers J, Drexler K Abstract Cocaine dependence continues to be a highly prevalent disorder, which is associated with significant morbidity and mortality. Numerous medications have been investigated as potential adjunctive therapeutic measures, but with minimal success. None have been given Food and Drug Administration approval for treatment of cocaine dependence. (Am J Addict 2011;00:1-2). PMID: 21838852 [PubMed - in process] (Source: American Journal on Addictions)

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Depressed Women at Higher Risk of Stroke

About.com Depression — Mon, 15 Aug 2011 23:00:00 +0100

Women with clinical depression are 29% more likely to suffer a stroke than other women of the same age, says a new article published in the journal Stroke. If they are using SSRI antidepressants - such as Prozac, Celexa or Zoloft - their risk is 39% higher....Read Full Post (Source: About.com Depression)

FDA Alert - Heart Risk With High Doses of Celexa

About.com Bipolar Disorder — Mon, 15 Aug 2011 23:00:00 +0100

The FDA warns that Celexa (citalopram) should not be used at dosages higher than 40mg per day. Celexa is an SSRI antidepressant that used to have a maximum dosage of 60mg per day. However, it has been found that more than 40mg per day can cause abnormal changes in the electrical activity of the heart. In addition, says the FDA, Celexa should not be given to patients with congestive heart failure, low levels of potassium or magnesium in the blood, or other conditions that can affect heart rhythm. If you are taking Celexa or citalopram at more than 40mg per day, contact your doctor as soon as possible. Here is the complete FDA warning: Celexa (citalopram hydrobromide): Drug Safety Communication - Abnormal Heart Rhythms Associated With High Doses, which you can print out to mail to your doc...

Marked Mydriasis and Neuritis Nervi Optici Associated with Galactorrhea Following Citalopram Treatment: A Case Report and Discussion

Infectious Diseases in Obstetrics and Gynecology — Mon, 15 Aug 2011 15:14:14 +0100

We report the case of a 25-year-old women suffering from major depression who was treated with citalopram for several weeks with doses between 20 mg and 60 mg. She gradually developed marked mydriasis within 2 months after treatment and subsequently neuritis nervi optici. Moreover, abrupt galactorrhea occurred after 2 months of treatment. All neuro-ophthalmological, neurophysiological, clinical laboratory, and neuroradiological diagnostic efforts did not reveal an underlying organic pathophysiology. The ocular symptoms disappeared rapidly after the discontinuation of citalopram and pulse therapy with methyl-prednisolone. However, galactorrhea persisted for a few weeks necessitating treatment with bromocriptine. (Source: Infectious Diseases in Obstetrics and Gynecology)

Depression Linked To Increased Risk Of Stroke In Women

Health News from Medical News Today — Mon, 15 Aug 2011 07:00:00 +0100

Depressed women may face an increased risk of stroke, according to new research reported in Stroke: Journal of the American Heart Association. In six years of follow-up of women in the Nurses' Health Study, researchers found that a history of depression was associated with a 29 percent increased risk of total stroke - even after considering other stroke risk factors. Women who used anti-depressant medication - particularly selective serotonin reuptake inhibitors - had a 39 percent increased risk of stroke. Examples of these drugs are Prozac, Zoloft, and Celexa... (Source: Health News from Medical News Today)

Estradiol and progesterone modify the effects of the serotonin reuptake transporter polymorphism on serotonergic responsivity to citalopram.

Experimental and Clinical Psychopharmacology — Mon, 15 Aug 2011 04:00:00 +0100

Individual vulnerability to psychopathologies is linked to a number of genetic polymorphisms including the serotonin transporter (5HTT) promoter polymorphic region (5HTTLPR). A single copy of the short variant (s-variant) allele of 5HTTLPR confers increased susceptibility to anxiety disorders and depression and decreased efficacy of serotonin-releasing agents in pharmacotherapy compared to the homozygous long 5HTTLPR variant (l/L). The data suggesting that the 5HTTLPR polymorphism modulates the efficacy of serotonin-releasing agents in pharmacotherapy is inconsistent. Other factors such as age, gender, and hormonal status could interact with 5HTTLPR genotype to affect individual physiological and behavioral responses to serotonin reuptake inhibitors such as citalopram. Indeed, estradiol an...

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Depression Raises Female Risk Of Stroke By 29%

Health News from Medical News Today — Sun, 14 Aug 2011 00:00:00 +0100

Adult females with clinical depression are 29% more likely to suffer a stroke than other women of the same age without depression, according to an article published in the journal Stroke. The authors, from Harvard Medical School added that there is a 39% higher risk for those on SSRIs (selective serotonin reuptake inhibitors). Examples of SSRIs include Prozac, Celexa and Zoloft. The investigators performed a six-year follow-up in the Nurses' Health Study, which included 80,574 females aged from 54 to 79 years. The study spanned from 2000 to 2006. None of the women had a history of stroke... (Source: Health News from Medical News Today)

SENTRALOPRAM AM-10 (Citalopram Hydrobromide, Choline) Kit [Physician Therapeutics LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 12 Aug 2011 05:00:00 +0100

Updated Date: Aug 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Depression In Females Linked To Higher Stroke Risk

Health News from Medical News Today — Fri, 12 Aug 2011 02:00:00 +0100

Women who suffer from depression have a 29% higher risk of having a stroke, researchers from Brigham and Women's Hospital in Boston, Mass. and Harvard Medical School wrote in the journal Stroke. Those on SSRIs (selective serotonin reuptake inhibitors), such as Celexa, Zoloft or Prozac, have a 39% higher risk, the authors informed. The researchers carried out a six-year follow-up in the Nurses' Health Study involving 80,574 women aged 54 to 79 years from 2000 to 2006. None of them had a history of stroke. Senior author, Dr... (Source: Health News from Medical News Today)

Amiodarone/citalopram interaction: Torsade de pointes in an elderly patient: case report

Reactions — Wed, 10 Aug 2011 17:36:32 +0100

(Source: Reactions)

CITALOPRAM HYDROBROMIDEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 08 Aug 2011 05:00:00 +0100

Updated Date: Aug 8, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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CITALOPRAM (Citalopram Hydrobromide) Tablet, Film Coated [Apotex Corp.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 01 Aug 2011 05:00:00 +0100

Updated Date: Aug 1, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CITALOPRAM (Citalopram Hydrobromide) Tablet, Film Coated [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 29 Jul 2011 05:00:00 +0100

Updated Date: Jul 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CITALOPRAM HYDROBROMIDEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 29 Jul 2011 05:00:00 +0100

Updated Date: Jul 29, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Neuroendocrine Assessment of Serotonergic, Dopaminergic, and Noradrenergic Functions in Alcohol‐Dependent Individuals

Alcoholism: Clinical and Experimental Research — Wed, 27 Jul 2011 23:00:00 +0100

Conclusions: The monoaminergic dysfunction was restricted to an impairment of the serotonergic system, suggesting that this system is especially vulnerable to long‐term and excessive alcohol consumption. Moreover, impaired monoaminergic profiles, including low responses in 2 or 3 systems, were more frequently observed in alcohol‐dependent individuals than in controls. Such impaired profiles may be of clinical importance, but further studies are needed. (Source: Alcoholism: Clinical and Experimental Research)

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Antidepressants and the risk of sudden cardiac death and ventricular arrhythmia

Pharmacoepidemiology and Drug Safety — Wed, 27 Jul 2011 23:00:00 +0100

ConclusionsOf antidepressants studied, only mirtazapine had a statistically significantly greater SD/VA risk versus paroxetine. However, baseline differences between these users suggest that this finding may be attributable to residual confounding. Eleven other antidepressants had SD/VA risks no greater than that of paroxetine, thereby providing reassurance regarding the comparative cardiovascular safety of antidepressants. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)

Neuroendocrine Assessment of Serotonergic, Dopaminergic, and Noradrenergic Functions in Alcohol-Dependent Individuals.

Alcoholism, Clinical and Experimental Research — Wed, 27 Jul 2011 23:00:00 +0100

Conclusions: The monoaminergic dysfunction was restricted to an impairment of the serotonergic system, suggesting that this system is especially vulnerable to long-term and excessive alcohol consumption. Moreover, impaired monoaminergic profiles, including low responses in 2 or 3 systems, were more frequently observed in alcohol-dependent individuals than in controls. Such impaired profiles may be of clinical importance, but further studies are needed. PMID: 21797890 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)

Citalopram improves metabolic risk factors among high hostile adults: Results of a placebo-controlled intervention

Psychoneuroendocrinology — Mon, 25 Jul 2011 22:35:46 +0100

Summary: Hostility is associated with a number of metabolic risk factors for cardiovascular disease, including waist–hip ratio, glucose, and triglycerides. Along with hostility, many of these measures have also been shown to be associated with reduced central serotonergic function. We have previously reported that a citalopram intervention was successful in reducing hostility by self-report assessment (). Here we examine the effects of this serotonergic intervention on metabolic risk factors in the same sample. 159 healthy adults with elevated hostility scores were randomized to citalopram or placebo for a 2-month period. Citalopram favorably changed metabolic risk factors, including waist circumference (p=.003), glucose (p=.02), HDL cholesterol (p=.04), triglycerides (p=.03), insulin se...

How Long Do Antidepressants Take to Work?

Psych Central — Mon, 25 Jul 2011 14:34:22 +0100

A common treatment for clinical depression is a type of medication called an antidepressant. Antidepressants come in a variety of forms, but all of them work by impacting certain neurochemicals in your brain, such as serotonin and norepinephrine. Antidepressants are most commonly prescribed by a psychiatrist, but may also be prescribed by a family physician or general practitioner to treat depression. The different classes of antidepressants include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), norepinephrine (noradrenaline) reuptake inhibitors, atypical antidepressants, tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs). Different classes of antidepressants take different amounts of time before you will star...

Science News » For Minor Depression, Study Shows No Benefit Over Placebo from St. John’s Wort, Citalopram

National Institute of Mental Health — Sun, 24 Jul 2011 08:02:13 +0100

An extract of the herb St. John's Wort and a standard antidepressant medication both failed to outdo a placebo in relieving symptoms of minor depression in a clinical trial comparing the three. The results of this study, consistent with earlier research, do not in support the use of medications for mild depression. (Source: National Institute of Mental Health)

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Differential pattern of response in mood symptoms and suicide risk measures in severely ill depressed patients assigned to citalopram with placebo or citalopram combined with lithium: Role of lithium levels. - Khan A, Khan SR, Hobus J, Faucett J, Mehra V, Giller EL, Rudolph RL.

SafetyLit: All (Unduplicated) — Sun, 24 Jul 2011 00:27:55 +0100

The assumption that antidepressants may reduce suicide risk by reducing depressive symptoms is not based on data. Further, it is unclear if the retrospectively based anti-suicidal effects of lithium can be prospectively evaluated using lithium as an augmen... (Source: SafetyLit: All (Unduplicated))

CITALOPRAM HYDROBROMIDEtablet [REMEDYREPACK INC. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 22 Jul 2011 05:00:00 +0100

Updated Date: Jul 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CITALOPRAM HYDROBROMIDEtablet [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 21 Jul 2011 05:00:00 +0100

Updated Date: Jul 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters [Pharmacology]

Proceedings of the National Academy of Sciences — Mon, 18 Jul 2011 23:00:00 +0100

In this study, the structural basis for selectivity of the SERT selective inhibitor citalopram and the structurally closely related NET selective inhibitor talopram is delineated. A systematic structure-activity relationship study allowed identification of the substituents that control activity and selectivity toward SERT and NET and revealed a common pattern showing that SERT and NET have opposite preference for the stereochemical configuration of these inhibitors. Mutational analysis of nonconserved SERT/NET residues within the central substrate binding site was performed to determine the molecular basis for inhibitor selectivity. Changing only five residues in NET to the complementary residues in SERT transferred a SERT-like affinity profile for R- and S-citalopram into NET, showing tha...

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CITALOPRAM (Citalopram Hydrobromide) Tablet, Film Coated [Greenstone LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 15 Jul 2011 05:00:00 +0100

Updated Date: Jul 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Concomitant blockade of 5-HT1A receptor and 5-HT transporter: Use of the Hunter Serotonin Toxicity Criteria in a clinical pharmacology study

European Neuropsychopharmacology — Wed, 06 Jul 2011 04:00:00 +0100

Abstract: There is a potential risk that 5-HT1A receptor blockade combined with blockade of the 5-HT transporter by an SSRI may cause a toxic increase in 5-HT within the synapse, sparking concern for 'serotonin syndrome', a rare but potentially life threatening condition. We evaluated the safety and pharmacodynamics of the combination of the 5-HT1A antagonist lecozotan and the SSRI citalopram in a well-controlled Clinical Pharmacology Unit setting using the Hunter Serotonin Toxicity Criteria (HSTC), a set of validated decision rules featuring neurological and body temperature measurements, to detect any clinically relevant serotonin toxicity. Forty-three young healthy male subjects were randomized, to 2 parallel double-blind treatment groups following a 10-day citalopram 40mg run-in period...

The antidepressant fluoxetine but not citalopram suppresses synapse formation and synaptic transmission between Lymnaea neurons by perturbing presynaptic and postsynaptic machinery

European Journal of Neuroscience — Sun, 03 Jul 2011 23:00:00 +0100

This study provides the first direct evidence that fluoxetine and citalopram exert characteristic, non‐specific side effects that are unrelated to their function as SSRIs, and that fluoxetine is more detrimental to synaptic physiology and structure than citalopram. (Source: European Journal of Neuroscience)

Amitriptyline/citalopram/mirtazapine: Fatal serotonin syndrome: 2 case reports

Reactions — Sun, 03 Jul 2011 18:34:01 +0100

(Source: Reactions)

Cochrane Review: Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD)

Evidence-Based Child Health: A Cochrane Review Journal — Thu, 30 Jun 2011 23:00:00 +0100

AbstractBackgroundAutism spectrum disorders (ASD) are characterised by abnormalities in social interaction and communication skills, as well as stereotypic behaviours and restricted activities and interests. Selective serotonin reuptake inhibitors (SSRIs) are prescribed for the treatment of co‐morbidity associated with ASD such as depression, anxiety and obsessive‐compulsive behaviours.ObjectivesTo determine if treatment with an SSRI: 1. improves the core features of autism (social interaction, communication and behavioural problems); 2. improves other non‐core aspects of behaviour or function such as self‐injurious behaviour; 3. improves the quality of life of children and their carers; 4. has short and long term effects on outcome; 5. causes harms.Search strategyWe searched the C...

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Citalopram versus desipramine in treatment resistant depression: Effect of continuation or switching strategies. A randomized open study.

The World Journal of Biological Psychiatry — Thu, 30 Jun 2011 23:00:00 +0100

Conclusions. This study supports the thesis that switching from an SSRI to a TCA (and vice versa) in non-responders to a 4-week trial of an SSRI/TCA is not associated with improved response. The result goes in the opposite direction to that predicted by current guidelines. PMID: 21718212 [PubMed - as supplied by publisher] (Source: The World Journal of Biological Psychiatry)

Citalopram/cyclophosphamide: Hyponatraemia: case report

Reactions — Mon, 27 Jun 2011 18:24:12 +0100

(Source: Reactions)

CITALOPRAM HYDROBROMIDEtablet [Bryant Ranch Prepack]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 17 Jun 2011 05:00:00 +0100

Updated Date: Jun 17, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CITALOPRAM HYDROBROMIDEsolution [Silarx Pharmaceuticals, Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 15 Jun 2011 05:00:00 +0100

Updated Date: Jun 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm: Citalopram

Citalopram shown to cause QT prolongation, says Health Canada

Citalopram/scopolamine: Central anticholinergic syndrome: case report

Ciprofloxacin/citalopram interaction: Torsades de pointes in an elderly patient: case report

Severity of depression and response to antidepressants: GENPOD randomised controlled trial [PAPERS]

A case of a suicide attempt with citalopram (Celexa) causing suppression of sinusal rhythm with development of atrial rhythm - Korkmaz S, Korkmaz H, Atmaca M, Kuloðlu M.

Table of Contents

Citalopram: Poor neonatal adaptation syndrome following in utero exposure: case report

Antidepressants

Resumption of food and fluid intake in Alzheimer's disease with severe apathy following intravenous citalopram

Citalopram: Hyperactivity in a child: case report

Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior.

Premenstrual syndrome and premenstrual dysphoric disorder (review)

On the Medication Carousel

A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia.

Blockade of the high‐affinity norepinephrine transporter (NET) by the selective serotonin reuptake inhibitor escitalopram: an in vivo microdialysis study in mice

Antidepressants Increase Risk for Nursing Home Falls in Patients With Dementia

CITALOPRAM HYDROBROMIDEtablet [International Labs, Inc.]

Podcast: Changing FDA Recommendations on Citalopram. . Why Now?

Podcast: Observations on FDA Recommendations for Citalopram Dosage

A short update on the structure of drug binding sites on neurotransmitter transporters

Severity of depression and response to antidepressants: GENPOD randomised controlled trial

Drug-induced immune thrombocytopaenia: results from the Berlin Case–Control Surveillance Study

Citalopram: Hepatotoxicity in an elderly patient: case report

MHRA: New data on QT interval prolongation with citalopram and escitalopram lead to changes in dose and cautions/contraindications

CITALOPRAM (Citalopram ) Tablet, Film Coated CITALOPRAM (Citalopram Hydrobromide) Tablet, Film Coated [Apotex Corp.]

Massive quetiapine overdose causes delayed cardiotoxicity

Detection of Amitriptyline, Citalopram, and Metabolites in Porcine Bones Following Extended Outdoor Decomposition*

CITALOPRAM HYDROBROMIDEtablet [Caraco Pharmaceutical Laboratories, Ltd.]

Dissociable effects of monoamine reuptake inhibitors on distinct forms of impulsive behavior in rats

A Double-Blind Placebo-Controlled Trial of Fluoxetine for Repetitive Behaviors and Global Severity in Adult Autism Spectrum Disorders.

Psychotherapeutic and Pharmacologic Treatment of Schizotypal Personality Disorder: The Heuristic Utility of Stressing Function Over Form

Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test

Therapeutic interventions for vascular depression: a systematic review.

Augmentation by escitalopram, but not citalopram or R‐citalopram, of the effects of low dose risperidone. Behavioral, biochemical and electrophysiological evidence

Augmentation by escitalopram, but not citalopram or R‐citalopram, of the effects of low‐dose risperidone: Behavioral, biochemical, and electrophysiological evidence

Problem-based review: paracetamol overdose. - Heaps T.

The importance of drug–drug interactions as a cause of adverse drug reactions: a pharmacovigilance study of serotoninergic reuptake inhibitors in France

CELEXA (Citalopram Hydrobromide) Tablet, Film Coated [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC ]

CITALOPRAM (Citalopram) Tablet [H.J. Harkins Company, Inc.]

TGA advises of dosing change for citalopram

Citalopram/zopiclone: Various toxicities: case report

Celexa / Citalopram Maximum Dosage Cut from 60 to 40mg - What Will That Mean to You?

Outcomes on the pharmacopsychometric triangle in bupropion‐SR vs. buspirone augmentation of citalopram in the STAR*D trial

Health Canada is reviewing the heart-related safety of citalopram

CITALOPRAM HYDROBROMIDEtablet [PD-Rx Pharmaceuticals, Inc.]

Perinatal antidepressant exposure alters cortical network function in rodents [Neuroscience]

Lundbeck communication on link between citalopram (Cipramil) and dose dependent QT interval prolongation

Neonatal Citalopram Treatment Inhibits the 5-HT Depleting Effects of MDMA Exposure in Rats

Effect of chronic variable stress on corticosterone levels and hippocampal extracellular 5‐HT in rats with persistent differences in positive affectivity

A review of escitalopram and citalopram in child and adolescent depression.

Antidepressant Linked to Autistic Behavior

Tamoxifen/paroxetine/citalopram interaction: Hot flashes and first report of an interaction, leading to altered tamoxifen metabolite concentrations: case report

Brain Development In Rats Stunted By Perinatal Antidepressant

Perinatal antidepressant stunts brain development in rats

FDA warns about linezolid, methylene blue association with serotonin syndrome

Depression in children and adolescents

Premenstrual syndrome and premenstrual dysphoric disorder.

Health Canada reviewing antidepressant Celexa

Correlation of QTc Interval ­Prolongation and Serum Level of Citalopram after Intoxication – A Case Report

Table of Contents

What Citalopram Tells Us About Prescribing Practices

CITALOPRAM HYDROBROMIDEtablet, Film Coated [Forest Laboratories, Inc.]

CITALOPRAM HYDROBROMIDEtablet [International Labs, Inc.]

NHS pays millions of pounds more than it needs to for antidepressant drugs

Citalopram/escitalopram: Gastro-oesophageal reflux disease (first report with escitalopram): case report

Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.

CITALOPRAM HYDROBROMIDEtablet [Torrent Pharmaceuticals Limited]

The antidepressant citalopram inhibits delayed rectifier outward K+ current in mouse cortical neurons

Citalopram/fluorouracil: Sinus bradycardia: case report

Systematic review and meta-analysis of published placebo controlled trials of citalopram for major depressive disorder in adults

Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms.

[Interactions between metoprolol and antidepressants].

Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action

CITALOPRAM HYDROBROMIDEtablet [St Marys Medical Park Pharmacy]

Neonatal Exposure of Rats to Antidepressants Affects Behavioral Reactions to Novelty and Social Interactions in a Manner Analogous to Autistic Spectrum Disorders

Altered Expression of Tyrosine Hydroxylase in the Locus Coeruleus Noradrenergic System in Citalopram Neonatally Exposed Rats and Monoamine Oxidase A Knock Out Mice

Neonatal Exposure of Rats to Antidepressants Affects Behavioral Reactions to Novelty and Social Interactions in a Manner Analogous to Autistic Spectrum Disorders.

Altered Expression of Tyrosine Hydroxylase in the Locus Coeruleus Noradrenergic System in Citalopram Neonatally Exposed Rats and Monoamine Oxidase A Knock Out Mice.

Serotonin signaling is associated with lower amyloid-{beta} levels and plaques in transgenic mice and humans [Neuroscience]

Correlation of QTc Interval Prolongation and Serum Level of Citalopram after Intoxication – A Case Report