MedWorm: Clobetasol

Fluorescence spectroscopy as a tool to detect and evaluate glucocorticoid-induced skin atrophy

Lasers in Medical Science — Tue, 17 Jan 2012 07:17:27 +0100

Abstract Topical glucocorticoid (GC) therapy has been successfully used in the treatment of several common cutaneous diseases in clinical practice for a long time, and skin atrophy is one of the most typical cutaneous side effects of this therapy. The aim of this study was to evaluate the potential of noninvasive fluorescence spectroscopy (FS) technique in the detection and classification of GC-induced skin atrophy. A total of 20 male Wistar rats were used in the experimental protocol under controlled environmental conditions and with free access to food. One group received topical application of clobetasol propionate 0.05% for 14 days to induce cutaneous atrophy (atrophic group) and the other (control) group received only vehicle application following the same protoc...

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CLOBETASOL PROPIONATEshampoo [Sandoz, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 04 Jan 2012 05:00:00 +0100

Updated Date: Jan 4, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEshampoo [Actavis Mid Atlantic LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 03 Jan 2012 05:00:00 +0100

Updated Date: Jan 3, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATElotion [Actavis Mid Atlantic LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 03 Jan 2012 05:00:00 +0100

Updated Date: Jan 3, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Interleukin‐17‐ and protease‐activated receptor 2‐mediated production of CXCL1 and CXCL8 modulated by cyclosporine A, vitamin D3 and glucocorticoids in human keratinocytes

The Journal of Dermatology — Thu, 29 Dec 2011 05:00:00 +0100

AbstractProtease‐activated receptor 2 (PAR2) is a G protein‐coupled receptor which mediates a variety of functions in the skin including cutaneous inflammation. SLIGKV‐NH2, an agonist peptide for PAR2, enhanced the interleukin (IL)‐17‐induced production of two CXC chemokines, CXCL1 (GRO‐α) and CXCL8 (IL‐8), in normal human epidermal keratinocytes (NHEK) in a concentration‐dependent manner. The enhanced production of those chemokines was suppressed by a PAR2‐specific siRNA. The SLIGKV‐NH2‐induced production of both CXCL1 and CXCL8 was markedly reduced by cyclosporine A. The enhanced production of CXCL1 was suppressed by 1α, 24R‐dihydroxyvitamin D3, an active form of vitamin D3, and weakly by glucocorticoids, dexamethasone and clobetasol propionate, whereas producti...

Anti‐pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen‐induced scratching behavior

Experimental Dermatology — Tue, 20 Dec 2011 05:00:00 +0100

AbstractItch accompanies various skin diseases. As a number of mediators other than histamine can be involved in the itch sensation, H1 receptor antagonists are not necessarily effective in treating itch. External application of anti‐pruritic drugs is occasionally used as an alternative therapy for pruritic skin conditions, such as pruritus on primary non‐diseased, non‐inflamed skin. Even so, the actual effects of these drugs on the itch sensation have yet to be studied in detail. To verify the anti‐pruritic effects of crotamiton, capsaicin, and a corticosteroid on the itch sensation, we examined the inhibitory effects of these drugs on various pruritogen‐induced scratching behaviors in mice. Topical application of 10% crotamiton moderately inhibited histamine‐, serotonin‐, a...

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Topical interventions for genital lichen sclerosus.

Cochrane Database of Systematic Reviews — Tue, 20 Dec 2011 01:00:04 +0100

CONCLUSIONS: The current limited evidence demonstrates the efficacy of clobetasol propionate, mometasone furoate, and pimecrolimus in treating genital lichen sclerosus. Further RCTs are needed to determine the optimal potency and regimen of topical corticosteroids, examine other topical interventions, assess the duration of remission or prevention of flares, evaluate the reduction in the risk of genital squamous cell carcinoma or genital intraepithelial neoplasia, and examine the efficacy in improving the quality of the sex lives of people with this condition. PMID: 22161424 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Clobetasol/hydroquinone: Striae and cutaneous ochronosis: 2 case reports

Reactions — Fri, 16 Dec 2011 06:55:18 +0100

(Source: Reactions)

CLOBETASOL PROPIONATEsolution [Hi-Tech Pharmacal Co., Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 07 Dec 2011 05:00:00 +0100

Updated Date: Dec 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Glucocorticoid hedgehog agonists in neurogenesis.

Vitamins and Hormones — Fri, 02 Dec 2011 06:18:02 +0100

Authors: Wang J, Barak LS, Mook RA, Chen W Abstract The process of neurogenesis in mammals, which is prolific and widespread at birth, gradually slows with aging and in humans becomes restricted to areas including the cerebellum and hippocampus. It has been reported that exposure to glucocorticoids can impair neurogenesis in both adults and children. Glucocorticoids are known to bind with high affinity to intracellular receptors. Glucocorticoid blood levels are normally regulated by environmental stresses, but because of their clinical utility, exogenous glucocorticoids are frequently administered in drug formulations. Consequently, concerns have arisen about the consequences of glucocorticoid use on neurogenesis and health, especially in the pediatric population. In this article, ...

Corticosteroids/clobetasol: Central serous chorioretinopathy (first report with clobetasol): case report

Reactions — Thu, 01 Dec 2011 07:29:01 +0100

(Source: Reactions)

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CLOBETASOL PROPIONATEgel [Perrigo New York Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 23 Nov 2011 05:00:00 +0100

Updated Date: Nov 23, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETA (Clobetasol Propionate, Coal Tar) Kit [Tiber Laboratories, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 16 Nov 2011 05:00:00 +0100

Updated Date: Nov 16, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEgel CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEointment [Taro Pharmaceuticals U.S.A., Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 14 Nov 2011 05:00:00 +0100

Updated Date: Nov 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The efficacy of clobetasol propionate with varying dilutions of emollient determined by histamine wheal suppression test

Indian Journal of Dermatology — Fri, 04 Nov 2011 04:00:00 +0100

Conclusion: We conclude that steroids and emollients can be mixed in equal proportion (1:1) and the effect is same as steroid alone and increasing dilution of steroids with emollients was not effective in suppressing the wheal. (Source: Indian Journal of Dermatology)

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Cost‐effectiveness evaluation of clobetasol propionate shampoo (CPS) maintenance in patients with moderate scalp psoriasis: a Pan‐European analysis

Journal of the European Academy of Dermatology and Venereology — Mon, 31 Oct 2011 03:56:29 +0100

Conclusion This model suggests that CPS is cost‐effective in maintaining the success achieved in moderate scalp psoriasis patients. (Source: Journal of the European Academy of Dermatology and Venereology)

Health-Related Quality of Life and Patient-Defined Benefit of Clobetasol 0.05% in Women with Chronic Lichen Sclerosus of the Vulva

Dermatology — Mon, 10 Oct 2011 23:00:00 +0100

Dermatology (DOI:10.1159/000332831) (Source: Dermatology)

CLOBETASOL PROPIONATEcream [Taro Pharmaceuticals U.S.A., Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 03 Oct 2011 05:00:00 +0100

Updated Date: Oct 3, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pharmacokinetics study about topical clobetasol on oral mucosa

Journal of Oral Pathology and Medicine — Thu, 22 Sep 2011 04:00:00 +0100

Conclusions: Our study validates clobetasol systemic transmucosal absorption, also recommending a careful monitoring of patients in corticosteroid therapy to avoid local and systemic adverse effects. (Source: Journal of Oral Pathology and Medicine)

CLOBETASOL PROPIONATEemulsion [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 13 Sep 2011 05:00:00 +0100

Updated Date: Sep 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Topical therapy of hand eczema – analysis of the prescription profile from dermatologists in private practice

JDDG — Thu, 01 Sep 2011 04:00:00 +0100

Conclusions: The results show that the concept of the risk‐to‐benefit ratio is reflected by the prescription profile of topical corticosteroids (therapeutic index). However, even corticosteroids with a less favorable therapeutic index are sometimes prescribed, perhaps due to economic reasons. (Source: JDDG)

CLOBETASOL PROPIONATEaerosol, Foam [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 22 Aug 2011 05:00:00 +0100

Updated Date: Aug 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Seventy-nine-year-old man with Langerhans cell histiocytosis treated with cladribine

Journal of the American Academy of Dermatology — Fri, 12 Aug 2011 16:59:51 +0100

To the Editor: A 79-year-old white man presented with a 6-year history of a pruritic rash that had progressed to skin breakdown in the body fold areas. Prior therapy included itraconazole, ketoconazole, trimethoprim-sulfamethoxazole, clindamycin, minocycline, doxycycline, penicillin VK, mupirocin, nystatin cream, and clobetasol lotion without resolution. (Source: Journal of the American Academy of Dermatology)

CLOBETASOL PROPIONATEaerosol, Foam [Prasco LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 22 Jul 2011 05:00:00 +0100

Updated Date: Jul 22, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cormax Ointment (Clobetasol Propionate Ointment) - updated on RxList

RxList - New and Updated Drug Monographs — Thu, 14 Jul 2011 07:00:00 +0100

Cormax Ointment (Clobetasol Propionate Ointment) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

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Microparticulate Based Topical Delivery System of Clobetasol Propionate.

AAPS PharmSciTech — Mon, 11 Jul 2011 23:00:00 +0100

Authors: Badıllı U, Sen T, Tarımcı N Psoriasis is a chronic, autoimmune skin disease affecting approximately 2% of the world's population. Clobetasol propionate which is a superpotent topical corticosteroid is widely used for topical treatment of psoriasis. Conventional dosage forms like creams and ointments are commonly prefered for the therapy. The purpose of this study was to develop a new topical delivery system in order to provide the prolonged release of clobetasol propionate and to reduce systemic absorption and side effects of the drug. Clobetasol propionate loaded-poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres were prepared by oil-in-water emulsion-solvent evaporation technique. Particle size analysis, morphological characterization, DSC and XRD analyses and in vitr...

OLUX (Clobetasol Propionate) Aerosol, Foam [Stiefel Laboratories Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 11 Jul 2011 05:00:00 +0100

Updated Date: Jul 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Efficacious and safe management of moderate to severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0·05% combined with ketoconazole shampoo 2%: a randomized, controlled study.

The British Journal of Dermatology — Thu, 30 Jun 2011 23:00:00 +0100

Conclusions The combination therapy of twice-weekly CP alternating with twice-weekly KC provided significantly greater efficacy than KC alone and a sustained effect in the treatment of moderate to severe scalp seborrhoeic dermatitis. PMID: 21707573 [PubMed - in process] (Source: The British Journal of Dermatology)

Diagnosis and treatment of lichen planus.

American Family Physician — Thu, 30 Jun 2011 23:00:00 +0100

Authors: Usatine RP, Tinitigan M Lichen planus is a chronic, inflammatory, autoimmune disease that affects the skin, oral mucosa, genital mucosa, scalp, and nails. Lichen planus lesions are described using the six P's (planar [flat-topped], purple, polygonal, pruritic, papules, plaques). Onset is usually acute, affecting the flexor surfaces of the wrists, forearms, and legs. The lesions are often covered by lacy, reticular, white lines known as Wickham striae. Classic cases of lichen planus may be diagnosed clinically, but a 4-mm punch biopsy is often helpful and is required for more atypical cases. High-potency topical corticosteroids are first-line therapy for all forms of lichen planus, including cutaneous, genital, and mucosal erosive lesions. In addition to clobetasol, topical tac...

Efficacious and safe management of moderate to severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0·05% combined with ketoconazole shampoo 2%: a randomized, controlled study

British Journal of Dermatology — Mon, 27 Jun 2011 17:59:16 +0100

Conclusions The combination therapy of twice‐weekly CP alternating with twice‐weekly KC provided significantly greater efficacy than KC alone and a sustained effect in the treatment of moderate to severe scalp seborrhoeic dermatitis. (Source: British Journal of Dermatology)

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OLUX-E (Clobetasol Propionate) Aerosol, Foam [Stiefel Laboratories Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 15 Jun 2011 05:00:00 +0100

Updated Date: Jun 15, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

clobetasol foam - topical, Olux

MedicineNet Arthritis General — Tue, 24 May 2011 07:00:00 +0100

Title: clobetasol foam - topical, OluxCategory: MedicationsCreated: 3/2/2005Last Editorial Review: 5/24/2011 (Source: MedicineNet Arthritis General)

Reaction to phosphorescent pigment in a nonprofessional tattoo

Journal of the American Academy of Dermatology — Wed, 18 May 2011 16:52:03 +0100

To the Editor: A recent survey conducted in the United States revealed that 120 of 500 (24%) respondents had at least one tattoo. Of these respondents, 32 (26%) had nonprofessional tattoos applied by themselves, a family member, or a friend. The dangers of this approach are highlighted by the case of a 24-year-old woman who was evaluated for severe pruritus, swelling, pain, and draining sores at the sites of “glow in the dark” tattoos on both wrists; her symptoms had been worsening over the course of 5 months. A friend used a needle to insert LumiNova (United Mineral & Chemical Corp, Lyndhurst, NJ) without dilution under the skin. The physical examination revealed violaceous, edematous, and ulcerated linear plaques in the shape of smiling faces circumferentially around both wrists (). ...

A consideration when interpreting outpatient data

Journal of the American Academy of Dermatology — Wed, 18 May 2011 16:51:59 +0100

To the Editor: The research letter entitled “Percuta-neous absorption of potent topical corticosteroids in patients with severe atopic dermatitis” reported that patients with suppressed serum cortisol at discharge from hospital had normal serum cortisol levels an average of 41 days after hospitalization, despite maintenance doses of clobetasol (mean dose, 27 g/wk) or betamethasone valerate (mean dose, 34 g/wk). The study presumably utilized medication weights to assess how much medication patients used; however, medication weights and self-reporting of outpatient topical medication use can grossly overestimate the actual dosage used. The possibility of poor adherence must be considered and, without objective assessment, it is difficult to know whether medication was truly applied. The...

Discoid Lupus Erythematosus in a Teenager

The Journal of Pediatrics — Tue, 17 May 2011 23:00:00 +0100

A 15-year-old African-American girl presented with a 5-year history of asymptomatic enlarging facial plaques. The plaques had been previously diagnosed as tinea and treated with various topical and oral antifungals without improvement. Examination revealed a 2 cm × 1 cm hyperkeratotic, indurated plaque on the left medial canthus and similar smaller plaques with central depression and elevated borders on the nose and right cheek (, A). Analysis of a skin biopsy specimen confirmed discoid lupus erythematosus (DLE). Serologic evaluation revealed a positive SSA/Ro antibody; all other serologic and routine laboratory test values were normal. Hydroxychloroquine 200 mg twice daily, clobetasol ointment twice daily, and photoprotection were instituted, which stabilized the plaques and prevented t...

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Improved efficacy in the treatment of contact dermatitis in rats by a dermatological nanomedicine containing clobetasol propionate.

European Journal of Pharmaceutics and Biopharmaceutics — Fri, 13 May 2011 23:00:00 +0100

Authors: Fontana MC, Rezer JF, Coradini K, Leal DB, Beck RC We developed a dermatological nanomedicine containing clobetasol propionate-loaded nanocapsules and evaluated its efficacy in a model of contact dermatitis after topical administration in rats. Hydrogels containing clobetasol propionate-loaded lipid-core nanocapsules or nanoemulsion (HG-CP-NC and HG-CP-NE, respectively) were prepared to evaluate the influence of the polymeric wall. They presented adequate pH values (5.50-6.50) and drug content (0.5mgg(-1)) and their rheograms exhibited a non-Newtonian pseudoplastic behavior. The best in vitro drug release control was obtained for HG-CP-NC (1.03±0.11μgcm(-2)h) compared to the HG-CP-NE (1.65±0.19μgcm(-2)h) and the hydrogels containing nonencapsulated drug (HG-CP) (2.79±0.22...

CLOBETA (Clobetasol Propionate, Coal Tar) Kit [Tiber Laboratories, LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 05 May 2011 05:00:00 +0100

Updated Date: May 5, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEointment [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 02 May 2011 05:00:00 +0100

Updated Date: May 2, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Isolated genital annular lichen planus.

Acta Dermatovenerologica Alpina, Panonica, et Adriatica — Sat, 30 Apr 2011 23:00:00 +0100

We present a case of a 29-year- -old circumcised man with an asymptomatic annular lesion of the penis. Histopathological features were consistent with LP. Topical clobetasol was prescribed, with clinical improvement. It is important to consider annular LP among the possible diagnoses of individual annular genital lesions. PMID: 21879203 [PubMed - in process] (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)

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OLUX-E (Clobetasol Propionate) Aerosol, Foam [Stiefel Laboratories Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 26 Apr 2011 05:00:00 +0100

Updated Date: Apr 26, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Comparison of clobetasol propionate cream plus coal tar vs. topical psoralen and solar ultraviolet A therapy in palmoplantar psoriasis

Clinical And Experimental Dermatology — Tue, 19 Apr 2011 23:00:00 +0100

Conclusion. Both treatments had comparable efficacy. In both groups, patients experienced ‘good improvement’ after 16 weeks of therapy. (Source: Clinical And Experimental Dermatology)

Monitoring of clobetasol propionate and betamethasone dipropionate as undeclared steroids in cosmetic products manufactured in Korea

Forensic Science International — Wed, 06 Apr 2011 23:00:00 +0100

Abstract: Some cosmetic products manufactured in Korea have been suspected to contain anti-inflammatory corticosteroids, such as clobetasol propionate and betamethasone dipropionate, for the treatment of eczema, seborrhea and psoriasis, without any indication on the label of the cosmetic products. Due to their severe side effects, such as permanent skin atopy, these two corticosteroids in cosmetic products need to be monitored from a forensic point of view. Cosmetic product samples (number of samples=47) of manufacturers charged by consumers have been collected in local and online markets of Korea, and they were validated and analyzed by a simple high performance liquid chromatography (HPLC) method with ultraviolet diode array (UV-DAD). LC–MS/MS and LC–MS were used to confirm these ste...

CLOBEX (Clobetasol Propionate) Spray [Galderma Laboratories, L.P.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 06 Apr 2011 05:00:00 +0100

Updated Date: Apr 6, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clobetasol: Cushing syndrome and adrenal insufficiency in an infant: case report

Reactions — Mon, 04 Apr 2011 16:58:12 +0100

(Source: Reactions)

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A double‐blind randomized placebo‐controlled trial of topical tacrolimus 0.1% versus clobetasol propionate 0.05% in childhood vitiligo.

British Journal of Dermatology — Thu, 31 Mar 2011 23:00:00 +0100

Conclusions: Both CP 0.05% and T 0.1% ointments offer similar benefit in both paediatricfacial and non facial vitiligo. The facial lesions responded faster than the non‐facial ones. (Source: British Journal of Dermatology)

A double-blind randomized placebo-controlled trial of topical tacrolimus 0.1% versus clobetasol propionate 0.05% in childhood vitiligo.

The British Journal of Dermatology — Thu, 31 Mar 2011 23:00:00 +0100

Conclusions: Both CP 0.05% and T 0.1% ointments offer similar benefit in both paediatric facial and non facial vitiligo. The facial lesions responded faster than the non-facial ones. PMID: 21457214 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

A double‐blind, randomized, placebo‐controlled trial of topical tacrolimus 0·1% vs. clobetasol propionate 0·05% in childhood vitiligo

British Journal of Dermatology — Thu, 31 Mar 2011 23:00:00 +0100

Conclusions Both CP 0·05% and T 0·1% ointments offer similar benefit in paediatric vitiligo, both facial and nonfacial. The facial lesions responded faster than the nonfacial ones. (Source: British Journal of Dermatology)

CLOBETASOL PROPIONATEaerosol, Foam [Perrigo New York Inc]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 24 Mar 2011 05:00:00 +0100

Updated Date: Mar 24, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Evaluation of topical 0.1% tazarotene cream in the treatment of palmoplantar psoriasis: An observer-blinded randomized controlled study

Indian Journal of Dermatology — Thu, 10 Mar 2011 00:00:00 +0100

Conclusion : Tazarotene is as effective as clobetasol propionate and provides a good alternative for the treatment of palmo-plantar psoriasis where hypopigmentation limits the use of clobetasol propionate cream. (Source: Indian Journal of Dermatology)

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[Bullous pemphigoid: A review.]

Annales de Dermatologie et de Cenereologie — Tue, 01 Mar 2011 00:00:00 +0100

CONCLUSIONS: Ultrapotent topical corticosteroids (clobetasol propionate; 20 to 40g/day) are effective treatments for BP with fewer systemic side-effects than oral high-dose corticosteroids. Systemic corticosteroids are effective but doses greater than 0.5mg/kg per day are associated with severe side-effects, including decreased survival. The effectiveness of the addition of plasma exchange or immunosuppressants (azathioprine, mycophenolate mofetil) to systemic corticosteroids has not been established. Combination treatment with tetracycline and nicotinamide needs further validation. PMID: 21397147 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)

A double-blind, randomized controlled trial of clobetasol versus pimecrolimus in patients with vulvar lichen sclerosus

Journal of the American Academy of Dermatology — Mon, 28 Feb 2011 00:00:00 +0100

Conclusion: Both clobetasol and pimecrolimus appear efficacious and well tolerated for the treatment of vulvar LS; however, clobetasol is more effective than pimecrolimus and should remain first-line therapy for LS. (Source: Journal of the American Academy of Dermatology)

Clobex Spray (Clobetasol Propionate Spray) - updated on RxList

RxList - New and Updated Drug Monographs — Fri, 25 Feb 2011 07:00:00 +0100

Clobex Spray (Clobetasol Propionate Spray) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

CLOBEX (Clobetasol Propionate) Lotion [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 24 Feb 2011 05:00:00 +0100

Updated Date: Feb 24, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Efficacious and safe management of moderate‐to‐severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0.05% combined with ketoconazole shampoo 2%: a randomised, controlled study

British Journal of Dermatology — Thu, 24 Feb 2011 00:00:00 +0100

Conclusion: The combination therapy of twice weekly clobetasol shampoo alternating with twice weekly ketoconazole shampoo provided significantly greater efficacy than ketoconazole alone and a sustained effect in the treatment of moderate‐to‐severe scalp SD. (Source: British Journal of Dermatology)

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Clobetasol/corticosteroids: Tinea incognito: case report

Reactions — Thu, 17 Feb 2011 16:50:41 +0100

(Source: Reactions)

Rapid resolution of primary vulval adult Langerhans cell histiocytosis with very potent topical corticosteroids.

The Australasian Journal of Dermatology — Tue, 01 Feb 2011 00:00:00 +0100

We report a 62-year-old female patient presenting with an 18-month history of pruritus and burning of the vulva. Clinical examination of the vulva showed a tender nodule of the right labium minus. Histology confirmed Langerhans cell histiocytosis. Systemic involvement was excluded. Within 1 month the use of clobetasol propionate ointment led to resolution of both the patient's symptoms and the clinical appearance of the affected right labium minus. This resolution was maintained 12 months later. PMID: 21332684 [PubMed - in process] (Source: The Australasian Journal of Dermatology)

Erosive pustular dermatosis of the leg: Long-term control with topical tacrolimus.

The Australasian Journal of Dermatology — Tue, 01 Feb 2011 00:00:00 +0100

We report the cases of two women who developed erythematous skin plaques with pustules that coalesced and evolved into erosions and crusted areas. Histology showed epidermal spongiosis with subcorneal pustules and a dermal infiltrate with eosinophils and neutrophils. Lesions were treated with topical clobetasol propionate 0.05% for 10 days followed by topical tacrolimus daily until complete resolution, and then twice weekly for 1 year, without relapse. The response to topical corticosteroids and tacrolimus further support the close relationship with erosive pustular dermatosis of the scalp. Topical therapy with tacrolimus may offer good long-term disease control. PMID: 21332681 [PubMed - in process] (Source: The Australasian Journal of Dermatology)

CLOBEX (Clobetasol Propionate) Spray [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 21 Jan 2011 05:00:00 +0100

Updated Date: Jan 21, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEsolution [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 11 Jan 2011 05:00:00 +0100

Updated Date: Jan 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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CLOBETASOL PROPIONATEcream [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 11 Jan 2011 05:00:00 +0100

Updated Date: Jan 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEointment [Physicians Total Care, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 11 Jan 2011 05:00:00 +0100

Updated Date: Jan 11, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Study of reservoir effect of clobetasol propionate cream in an experimental animal model using histamine-induced wheal suppression test

Indian Journal of Dermatology — Tue, 04 Jan 2011 00:00:00 +0100

Conclusions: This work demonstrated that histamine-induced wheal by the topical steroid clobetasol propionate 0.05% cream was suppressed till day 4, indicating that the reservoir of topical corticosteroid persisted till day 4. (Source: Indian Journal of Dermatology)

Olux-E (Clobetasol Propionate Foam) - updated on RxList

RxList - New and Updated Drug Monographs — Thu, 16 Dec 2010 07:00:00 +0100

Olux-E (Clobetasol Propionate Foam) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

CLOBEX (Clobetasol Propionate) Spray [Galderma Laboratories, L.P.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 13 Dec 2010 05:00:00 +0100

Updated Date: Dec 13, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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CLOBETASOL PROPIONATEsolution [Rebel Distributors Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 10 Dec 2010 05:00:00 +0100

Updated Date: Dec 10, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Seborrhoeic dermatitis

Clinical Evidence — Tue, 07 Dec 2010 23:00:00 +0100

New evidence; conclusion confirmed for: Ketoconazole (scalp) One RCT added comparing ketoconazole 2% versus ciclopirox olamine 1.5% versus placebo. The RCT, which was primarily set up to assess the effectiveness of ciclopirox olamine, found that ketoconazole reduced scaling, itching, erythema, and global severity compared with placebo. Categorisation unchanged (Beneficial). Topical corticosteroids One RCT added comparing clobetasol propionate 0.05% shampoo applied for 2.5, 5, and 10 minutes versus placebo. The RCT found that clobetasol propionate 0.05% applied twice weekly for 2.5, 5, or 10 minutes improved total severity score compared with placebo; that clobetasol propionate 0.05% applied twice weekly for 5 minutes improved erythema and itchin...

Combination strategy may change psoriasis treatment

Modern Medicine — Sat, 27 Nov 2010 06:25:38 +0100

In early testing, an experimental protocol combining excimer laser (XTRAC Velocity, PhotoMedex), clobetasol spray and topical calcitriol ointment achieves fast, impressive results in patients with severe, generalized psoriasis. (Source: Modern Medicine)

CLOBETASOL PROPIONATEointment CLOBETASOL PROPIONATEcream [Rebel Distributors Corp]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 23 Nov 2010 05:00:00 +0100

Updated Date: Nov 23, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEointment [Golden State Medical Supply, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 22 Nov 2010 05:00:00 +0100

Updated Date: Nov 22, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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CLOBETASOL PROPIONATEcream [Golden State Medical Supply, Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 22 Nov 2010 05:00:00 +0100

Updated Date: Nov 22, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBEX (Clobetasol Propionate) Lotion [Galderma Laboratories, L.P.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 12 Nov 2010 05:00:00 +0100

Updated Date: Nov 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBEX (Clobetasol Propionate) Shampoo [Galderma Laboratories, L.P.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 02 Nov 2010 05:00:00 +0100

Updated Date: Nov 2, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Exogenous Cushing’s syndrome due to topical corticosteroid application: case report and review literature

Endocrine — Sat, 23 Oct 2010 05:46:19 +0100

We report on an 8-month-old female infant who developed Cushing’s syndrome and adrenal insufficiency after diaper dermatitis treatment through the misuse of Clobetasol without doctor’s prescription. Physiologic dose of hydrocortisone was prescribed to prevent an adrenal crisis for 3 months and discontinued when HPA axis recovery was confirmed by normal morning cortisol and ACTH levels. Content Type Journal ArticleDOI 10.1007/s12020-010-9393-6Authors Therdpong Tempark, Division of Dermatology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330 ThailandVoraluk Phatarakijnirund, Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Sor Kor Building 11th Floor, Bangkok, 10330 ThailandSusheera ...

Treatment of cutaneous myiasis associated with scalp psoriasis in a 13-year-old girl with oral ivermectin

Journal of the American Academy of Dermatology — Sat, 16 Oct 2010 08:40:54 +0100

To the Editor: We read with great interest the case report published by Mariwalla et al in the August 2007 issue of the Journal regarding a 12-year-old girl with severe myiasis and scalp psoriasis. Recently, we had a similar case involving a 13-year-old girl who presented to our clinic with multiple larvae on the scalp. She had a 4-year history of psoriasis mainly affecting the scalp. For the previous 6 months, she had been treated with clobetasol propionate shampoo 0.05% twice a week with poor control. Five days earlier, the patient and her family reported a short stay in a marshy area. The day preceding consultation, her relatives noticed the presence of numerous larvae on the scalp measuring 4 mm to 7 mm in length and 2 mm to 3 mm in diameter. The physical examination revealed the pres...

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Interventions for bullous pemphigoid.

Cochrane Database of Systematic Reviews — Fri, 15 Oct 2010 23:30:04 +0100

CONCLUSIONS: Very potent topical steroids are effective and safe treatments for BP, but their use in extensive disease may be limited by side-effects and practical factors. Milder regimens (using lower doses of steroids) are safe and effective in moderate BP. Starting doses of prednisolone greater than 0.75 mg/kg/day do not give additional benefit, lower doses may be adequate to control disease and reduce the incidence and severity of adverse reactions. The effectiveness of adding plasma exchange, azathioprine or mycophenolate mofetil to corticosteroids, and combination treatment with tetracycline and nicotinamide needs further investigation. PMID: 20927731 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Seronegative necrolytic acral erythema: A distinct clinical subset?

Indian Journal of Dermatology — Sun, 26 Sep 2010 08:11:28 +0100

S Panda, K LahiriIndian Journal of Dermatology 2010 55(3):259-261A patient was referred to us with asymptomatic, erythematous, nonitchy, scaly lesions present bilaterally on the dorsa of his feet and toes since the last 2 months. Both the legs had pitting edema as well. There were hyperkeratosis, focal parakeratosis, acanthosis and scattered spongiosis in the epidermis, and proliferation of capillaries with perivascular infiltration of lymphomononuclear cells in the dermis. There was no serological evidence of hepatitis C virus. Laboratory investigations revealed hypoalbuminemia and low-normal serum zinc. On clinicopathological correlation, we made a diagnosis of necrolytic acral erythema (NAE). The lesions responded dramatically to oral zinc sulfate and topical clobetasol propionate withi...

clobetasol foam - topical, Olux

MedicineNet Skin General — Wed, 22 Sep 2010 07:00:00 +0100

Title: clobetasol foam - topical, OluxCategory: MedicationsCreated: 3/2/2005Last Editorial Review: 9/22/2010 (Source: MedicineNet Skin General)

[Bullous pemphigoid.]

Presse Medicale — Tue, 07 Sep 2010 23:00:00 +0100

Authors: BÃ©nÃ©ton-Benhard N Bullous pemphigoid is the most frequent autoimmune bullous skin disease and affects subjects who are about 80Â years old. The risk factors are neurological degenerative diseases, poor Karnovski's status and some drugs (aldactone and neuroleptics). Typically, the disease consists of itching eczematous or urticarial sheets, surmounted by blisters. The blisters heal without scars. Mouth and head are rarely involved. The diagnostic is made by histological examination . It shows a subepidermal blister with some degree of dermal infiltrate with lymphocytes and eosinophils. Direct immunofluorescence reveals a linear pattern of IgG deposition along the basal membrane, which signs the diagnosis. Indirect immunofluorescence detecting anti-basal membrane antibod...

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A new mucoadhesive dosage form for the management of oral lichen planus: formulation study and clinical study.

European Journal of Pharmaceutics and Biopharmaceutics — Mon, 09 Aug 2010 23:00:00 +0100

Authors: Cilurzo F, Gennari CG, Selmin F, Epstein JB, Gaeta GM, Colella G, Minghetti P The work aimed to study a new mucoadhesive prolonged release tablet containing 24 mug clobetasol-17 propionate (CP) suitable for the management of oral lichen planus. Low swellable dosage forms were designed by combining a mucoadhesive polymer, i.e. poly(sodium methacrylate, methylmethacrylate), with hydroxypropylmethylcellulose and MgCl(2). This formulation was selected to modify the tablet erosion rate in order to obtain a release of CP over a 6 h period. A double-blind controlled study was performed using three groups of patient (n=16) which received 3 applications-a-day over 4 weeks of the developed CP tablets (group CP-T), placebo tablets (group CP-P) or commercial CP ointment for cutaneous appl...

Diagnosis and management of contact dermatitis.

American Family Physician — Sat, 31 Jul 2010 23:00:00 +0100

Authors: Usatine RP, Riojas M Contact dermatitis is a common inflammatory skin condition characterized by erythematous and pruritic skin lesions that occur after contact with a foreign substance. There are two forms of contact dermatitis: irritant and allergic. Irritant contact dermatitis is caused by the non-immune-modulated irritation of the skin by a substance, leading to skin changes. Allergic contact dermatitis is a delayed hypersensitivity reaction in which a foreign substance comes into contact with the skin; skin changes occur after reexposure to the substance. The most common substances that cause contact dermatitis include poison ivy, nickel, and fragrances. Contact dermatitis usually leads to erythema and scaling with visible borders. Itching and discomfort may also occur. A...

CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEointment [Glenmark Generics Inc., USA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 12 Jul 2010 05:00:00 +0100

Updated Date: Jul 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEemulsion [Glenmark Generics Inc., USA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 12 Jul 2010 05:00:00 +0100

Updated Date: Jul 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEsolution [Glenmark Generics Inc., USA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 12 Jul 2010 05:00:00 +0100

Updated Date: Jul 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Folliculocentric lichen sclerosus et atrophicus.

Skinmed — Thu, 01 Jul 2010 00:00:00 +0100

Authors: Mann DJ, Vergilis-Kalner IJ, Wasserman JR, Petronic-Rosic V A 71-year-old black woman presented to the dermatology clinic with a several-year history of increasing numbers of itchy white spots spreading over the chest, back, elbows, and legs. In 2004, the patient developed clusters of mildly pruritic hypopigmented and depigmented macules on her back and left shoulder along with depigmented flat papules on the lower extremities. The patient's condition was unresponsive to topical triamcinolone and tacrolimus, after which she was lost to follow-up for 3 years until her entire chest became involved. Her medical history was significant for hypertension and diabetes mellitus and her medications included amlodipine, aspirin, atorvastatin, hydrochlorothiazide, irbesartan, and metform...

Excimer laser vs. clobetasol propionate 0·05% ointment in prurigo form of atopic dermatitis: a randomized controlled trial, a pilot

British Journal of Dermatology — Wed, 30 Jun 2010 23:00:00 +0100

(Source: British Journal of Dermatology)

CORMAX (Clobetasol Propionate) Cream [DPT Laboratories, Ltd.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 22 Jun 2010 05:00:00 +0100

Updated Date: Jun 22, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEgel [Hi-Tech Pharmacal Co., Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 09 Jun 2010 05:00:00 +0100

Updated Date: Jun 9, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEemulsion [Hi-Tech Pharmacal Co., Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 09 Jun 2010 05:00:00 +0100

Updated Date: Jun 9, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEointment [Hi-Tech Pharmacal Co., Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 09 Jun 2010 05:00:00 +0100

Updated Date: Jun 9, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEsolution [Hi-Tech Pharmacal Co., Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 08 Jun 2010 05:00:00 +0100

Updated Date: Jun 8, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clobetasol: Cushing's syndrome in an infant, following topical therapy: case report

Reactions — Mon, 07 Jun 2010 13:08:52 +0100

(Source: Reactions)

Excimer laser versus clobetasol propionate 0.05% ointment in prurigo form of atopic dermatitis: a randomised controlled trial, a pilot.

The British Journal of Dermatology — Wed, 19 May 2010 23:00:00 +0100

Conclusion: This study suggests that the excimer laser can safely and effectively be used in the treatment of prurigo form of atopic dermatitis. For the long-term, the excimer laser might be a good alternative to topical corticosteroids and a option in case of therapy resistant patients. PMID: 20491772 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Excimer laser vs. clobetasol propionate 0·05% ointment in prurigo form of atopic dermatitis: a randomized controlled trial, a pilot

British Journal of Dermatology — Wed, 19 May 2010 23:00:00 +0100

Conclusions This study suggests that the EL can safely and effectively be used in the treatment of the prurigo form of AD. For the long term, the EL might be a good alternative to topical corticosteroids and an option in case of therapy-resistant patients. (Source: British Journal of Dermatology)

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Comparison of tape stripping with the human skin blanching assay for the bioequivalence assessment of topical clobetasol propionate formulations.

J Pharm Pharm Sci — Thu, 13 May 2010 11:08:05 +0100

CONCLUSIONS: These studies show that the results from tape stripping concur with data from the human skin blanching assay and demonstrate the potential of a well-controlled tape stripping study as an option for the assessment of bioequivalence of topical corticosteroid formulations. PMID: 20456826 [PubMed - in process] (Source: J Pharm Pharm Sci)

[Cutaneous infections in bullous pemphigoid patients treated with topical corticosteroids]

Annales de Dermatologie et de Cenereologie — Fri, 30 Apr 2010 23:00:00 +0100

CONCLUSION: In this study, we noted cutaneous superinfection in nine of 30 (30%) patients receiving topical corticosteroids for bullous pemphigoid, among which were three cases of fatal NF due to streptococcus A (10%). The infectious risks associated with TCS must not be neglected, particularly since treated patients are old and fragile, and frequently have multiple well-known risk factors for NF (e.g. extensive lesions, diabetes, etc.). In the event of signs of cutaneous superinfection, especially in cases of diabetes and prolonged TCS treatment, bacteriological analysis should be conducted. Adequate treatment should be initiated without delay, especially in cases of beta-haemolytic streptococcal infection. PMID: 20470914 [PubMed - in process] (Source: Annales de Dermatologie et de Ce...

Topical calcitriol restores the impairment of epidermal permeability and antimicrobial barriers induced by corticosteroids

British Journal of Dermatology — Wed, 21 Apr 2010 23:00:00 +0100

Conclusions We found that topical calcitriol restored both the epidermal permeability and antimicrobial barrier that had been impaired by corticosteroids. This restoration was mediated by both an activation of the cutaneous vitamin D pathway and an increase of epidermal lipids and antimicrobial peptides, promoted by the formation of the LB and the activity of epidermal lipid synthesis-related enzymes. (Source: British Journal of Dermatology)

Is Suppression of Hypothalamic-Pituitary-Adrenal Axis Significant During Clinical Treatment of Phimosis?

The Journal of Urology — Sun, 18 Apr 2010 23:00:00 +0100

Conclusions: Topical clobetasol propionate used twice daily for clinical treatment of phimosis does not affect the hypothalamus-pituitary-adrenal axis in most patients. However, salivary cortisol level should be considered as a laboratory marker in long-term treatment or during repeated cycles to detect possible hypothalamus-pituitary-adrenal axis suppression. (Source: The Journal of Urology)

Discoid chronic lupus erythematosus at the site of a previously healed cutaneous leishmaniasis: an example of isotopic response

Dermatologic Therapy — Sun, 04 Apr 2010 23:00:00 +0100

We report here the case of a 38-year-old woman who referred to us for an infiltrated, red-brownish plaque localized on her left cheek. The patient had been treated for a cutaneous leishmaniasis, confirmed by the histologic examination, localized at the same site. She was completely healed after an appropriate local and systemic treatment. She experienced the occurrence of the new plaque at the site of the previously healed cutaneous leishmaniasis three month later. Histologic examination and laboratory tests were consistent with a diagnosis of discoid cutaneous chronic lupus erythematosus. Treatment with hydroxychloroquine, topical clobetasol and topical tretinoin resulted in flattening and clearing of the lesion. Our case is the first case of isotopic response where a discoid chronic lupu...

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Gene expression profiling in psoriatic scalp hair follicles: clobetasol propionate shampoo 0.05% normalizes psoriasis disease markers

Journal of the European Academy of Dermatology and Venereology — Tue, 23 Mar 2010 00:00:00 +0100

Conclusion Hair follicles of SP patients are affected by the inflammatory process. The change in the expression level of inflammation-related genes correlates with the severity of the disease. (Source: Journal of the European Academy of Dermatology and Venereology)

Positivity ratio and reaction index: patch-test quality-control metrics applied to the north american contact dermatitis group database.

Dermatitis — Sat, 20 Mar 2010 00:42:34 +0100

CONCLUSION:Caution should be used when interpreting reactions to "problematic" patch-test preparations with a high proportion of weak, irritant, and questionable reactions. PMID: 20233547 [PubMed - in process] (Source: Dermatitis)

Severe inflammatory and keloidal, allergic reaction due to para-phenylenediamine in temporary tattoos

Indian Journal of Dermatology, Venereology and Leprology — Thu, 11 Mar 2010 14:10:55 +0100

We report a 22-year-old man who developed severe inflammatory and keloidal, moderately bullous allergic reaction after henna paint-on tattoo. We did a patch test separately with these painting products (henna powder, PPD) and with the European standard series. PPD was strongly positive (+++) on day 2 and remained positive for following days. After treating with topical clobetasol-17 butyrate, resolution was obtained in two weeks. But some keloidal reaction remained. (Source: Indian Journal of Dermatology, Venereology and Leprology)

Topical calcitriol restores the impairment of epidermal permeability and antimicrobial barriers induced by corticosteroid.

The British Journal of Dermatology — Wed, 10 Mar 2010 00:00:00 +0100

Conclusions: We found that topical calcitriol restored both the epidermal permeability and antimicrobial barrier that had been impaired by corticosteroid. This restoration was mediated by both an activation of the cutaneous vitamin D pathway and an increase of epidermal lipids and antimicrobial peptides, promoted by the formation of the lamellar body and the activity of epidermal lipid synthesis-related enzymes. PMID: 20302580 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Adjuvant triamcinolone acetonide injections in oro-pharyngeal pemphigus vulgaris

Journal of the European Academy of Dermatology and Venereology — Fri, 05 Mar 2010 00:00:00 +0100

Conclusion Perilesional/intralesional triamcinolone acetonide injections seems to represent a helpful clinical tool to successfully join CIST, in terms of shortening the time of complete clinical remission, reducing the total amount of corticosteroids and obtaining an acceptable compliance. (Source: Journal of the European Academy of Dermatology and Venereology)

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Review: Lichen sclerosus

NeLM - News — Tue, 16 Feb 2010 00:00:00 +0100

Source: BMJ Area: News The British Medical Journal has featured a review on the diagnosis and management of lichen sclerosis. The review starts with a case vignette, and discusses clinical features and investigations required for the diagnosis. In terms of management, the review states, "After diagnosis, the accepted treatment is with the very potent topical steroid clobetasol propionate ointment. No controlled trials have been published to establish the best regime, but the guidelines suggest a single application at night for four weeks followed by alternate nights for four weeks and then twice a week for four weeks. Once symptoms are well controlled, the steroid ointment is used as required. Some patients will achieve complete remission; others will require ongoing treatment....

HPA-suppressive effects of aqueous clobetasol propionate in the treatment of patients with oral lichen planus

Journal of the European Academy of Dermatology and Venereology — Wed, 10 Feb 2010 00:00:00 +0100

Conclusions Hypothalamus[ndash]pituitary[ndash]adrenal inhibition is substantial during initial treatment with aqueous CP three times daily. (Source: Journal of the European Academy of Dermatology and Venereology)

HPA‐suppressive effects of aqueous clobetasol propionate in the treatment of patients with oral lichen planus

Journal of the European Academy of Dermatology and Venereology — Mon, 01 Feb 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

CORMAX (Clobetasol Propionate) Ointment [DPT Laboratories, Ltd.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 28 Jan 2010 05:00:00 +0100

Updated Date: Jan 28, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CORMAX (Clobetasol Propionate) Ointment [Watson Pharma, Inc. ]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 27 Jan 2010 05:00:00 +0100

Updated Date: Jan 27, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice

Experimental Dermatology — Mon, 25 Jan 2010 00:00:00 +0100

Please cite this paper as: Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice. Experimental Dermatology 2010.Abstract: Topical corticosteroids such as hydrocortisone-17-butyrate (HCB) and clobetasol-17-propionate (CP) and vitamin D3 derivatives such as calcipotriol (CAL) are widely used to treat psoriasis. The immunosuppressive effects of corticosteroids make their topical use a concern for skin carcinogenicity. Few studies have assessed the effect of topical corticosteroids and topical vitamin D3 derivatives on photocarcinogenesis induced by ultraviolet radiation. We investigated whether HCB, CP, or CAL can accelerate photocarcinogenesis using simulated solar radiation (SSR). HCB, CP, ...

CLOBETASOL PROPIONATEaerosol, Foam [Prasco LLC]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 19 Jan 2010 05:00:00 +0100

Updated Date: Jan 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Rapid resolution of primary vulval adult Langerhans cell histiocytosis with very potent topical corticosteroids

Australasian Journal of Dermatology — Tue, 29 Dec 2009 00:00:00 +0100

Erosive pustular dermatosis of the leg: Long-term control with topical tacrolimus

Australasian Journal of Dermatology — Mon, 28 Dec 2009 00:00:00 +0100

Perrigo Confirms Filing For Generic Version Of Clobex® Spray And Announcement Of Lawsuit By Galderma And Dermalogix

Pharmaceutical Online News — Wed, 09 Dec 2009 08:42:00 +0100

Perrigo Company (Nasdaq: PRGO ; TASE) today announced that it has filed an Abbreviated New Drug Application for Clobetasol Propionate Topical Spray, 0.05%, a generic form of Clobex® Spray. (Source: Pharmaceutical Online News)

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Severe 20-nail psoriasis successfully treated by low dose methotrexate.

Dermatol Online J — Thu, 03 Dec 2009 20:46:04 +0100

We report a case of severe psoriatic nail dystrophy involving all 20 nails successfully treated by low dose MTX. A previously healthy 11-year-old girl presented with painful deformity involving all 20 nails that developed over a one-month period. Examination revealed geographic and fissured tongue, as well as severe nail dystrophy of all 20 nails characterized by erythematous swelling of the nail folds, yellowish discoloration of nail plates with pitting, severe crumbling and destruction, transverse depressions, prominent oil spots, and swelling of proximal nail. Topical clobetasol propionate and calcipotriol were tried first but the nail dystrophy continued to progress. Low dose of MTX (5 mg per week) was initiated. The response was fairly satisfactory with emergence of normal plate proxi...

CLOBETASOL PROPIONATEointment CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEgel [E. FOUGERA CO., A Division Of Nycomed US Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 02 Dec 2009 05:00:00 +0100

Updated Date: Dec 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Clobetasol: Mood disorders in an elderly patient: case report

Reactions — Mon, 30 Nov 2009 14:07:30 +0100

(Source: Reactions)

Ultrasound evaluation of clobetasol propionate 0.05% foam application in psoriatic and healthy skin: a pilot study

Dermatologic Therapy — Tue, 03 Nov 2009 00:00:00 +0100

The aim of the present study was to evaluate through ultrasound imaging the response to treatment of twice and once daily application of clobetasol propionate 0.05% foam on psoriatic skin as well as the atrophogenic potential of once daily application of the foam on healthy skin. The study included a total of 40 participants, 30 affected by Psoriasis vulgaris and 10 healthy volunteers. Patients with psoriasis were branched in two groups of 15 subjects: in the first group, clobetasol propionate 0.05% foam was applied twice daily for up to 2 weeks on targeted plaques, in the second group, it was applied once daily for up to 4 weeks. Ten healthy adult volunteers were instructed to apply the foam to a 4 × 4 cm area on the volar aspect of the forearm once daily for 4 weeks. Ultrasound evaluati...

Unilesional pemphigus vulgaris of the scalp after cochlear implantation

American Journal of Otolaryngology — Mon, 02 Nov 2009 00:00:00 +0100

In December 2004, a 69-year-old man came to the ENT unit of the University of Parma complaining of a painful cutaneous lesion in the left retroauricular region. The patient reported that the lesion appeared 4 weeks after a cochlear implantation procedure performed elsewhere 2 months before because of a bilateral profound deafness. The lesion was initially managed by his practitioner with oral and topical antibiotics in the suspicion of impetigo. Nevertheless, no benefits came after a 15-day antibiotic course. The patient's medical history included diagnosis of oral pemphigus vulgaris (PV) 6 years before that was treated with oral azathioprine and topical clobetasol dipropionate ointment. After complete clinical remission of the disease, a low-dose immunosuppressive therapy was prescribed f...

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CLOBETASOL PROPIONATEaerosol, Foam [DPT Laboratories, Ltd.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Mon, 26 Oct 2009 05:00:00 +0100

Updated Date: Oct 26, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Treatment of scalp psoriasis with clobetasol-17 propionate 0.05% shampoo: a study on daily clinical practice

Journal of the European Academy of Dermatology and Venereology — Tue, 20 Oct 2009 23:00:00 +0100

Conclusions Short-contact treatment with clobetasol-17 propionate 0.05% shampoo has high user convenience and patient satisfaction rates. Moreover, the treatment is well-tolerated and efficacious from patients' perspective. Subgroup analyses did not reveal factors predicting treatment outcome, although treatment success tended to be more evident in patients who had received fewer treatments previously. (Source: Journal of the European Academy of Dermatology and Venereology)

CLOBETASOL PROPIONATEsolution [E. FOUGERA CO. A Division Of Nycomed US Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 20 Oct 2009 05:00:00 +0100

Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Topical Clobetasol Propionate in the Treatment of Psoriasis: A Review of Newer Formulations

American Journal of Clinical Dermatology — Fri, 16 Oct 2009 13:00:23 +0100

(Source: American Journal of Clinical Dermatology)

Repeated mechanical trauma to the hands: the use of anti-impaction gloves for treatment and return to work.

Dermatitis — Wed, 30 Sep 2009 23:00:00 +0100

CONCLUSION: Anti-impaction gloves are shown to aid in the return-to-work process for those with FHD but not for those with HHD. PMID: 19808004 [PubMed - in process] (Source: Dermatitis)

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Double-blind, crossover, placebo-controlled clinical trial with clobetasol propionate in desquamative gingivitis.

Braz Dent J — Tue, 29 Sep 2009 22:50:03 +0100

Authors: Motta AC, Domaneschi C, Komesu MC, Souza Cda S, Aoki V, Migliari DA The aim of this study was to evaluate the efficacy of a 0.05% clobetasol propionate ointment administered in trays to 22 patients with desquamative gingivitis in a double-blind, crossover, placebo-controlled trial. Patients received container number 1 and were instructed to apply the ointment 3 times a day for 2 weeks, and to reduce the application to once a day in the third week. Next, the patients were then instructed to discontinue the treatment for 2 weeks, and were then given container 2, used in the same way and for the same length of time as container 1. Regarding signs, 17 patients presented some improvement, while 5 experienced worsening with clobetasol propionate. With the placebo, 14 patients presen...

TEMOVATE (Clobetasol Propionate) Solution [PharmaDerm, A Division Of Nycomed US Inc.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Thu, 24 Sep 2009 05:00:00 +0100

Updated Date: Sep 24, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

What's new in urticaria ?

Indian Journal of Dermatology — Thu, 10 Sep 2009 16:21:51 +0100

Ghosh SanjayIndian Journal of Dermatology 2009 54(3):280-282Urticaria, a perplexing disease of ever-changing explanations, is being renovated almost everyday by newer facts and findings accumulated from different parts of the globe. Cost of the urticaria treatment gradually grows higher and higher whereas the ailment disturbs the quality of life very adversely. Disorder of coagulation cascade has recently thrown some new light into its mechanism. Non-allergic angioedema induced by bradykinin caused by genetic defects and ACE-inhibitors has also been noted. Role of <i> H. pylori </i> in the pathogenesis of urticaria has also been re-reviewed. Urticaria could sometimes mimic erythema multiforme and is termed urticaria multiforme. Skin biopsy showed fea...

CLOBETASOL PROPIONATEemulsion [Glenmark Generics Inc., USA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 26 Aug 2009 05:00:00 +0100

Updated Date: Aug 26, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBEX (Clobetasol Propionate) Shampoo [DPT Laboratories, Ltd.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 25 Aug 2009 05:00:00 +0100

Updated Date: Aug 25, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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CORMAX (Clobetasol Propionate) Ointment [DPT Laboratories, Ltd.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 25 Aug 2009 05:00:00 +0100

Updated Date: Aug 25, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEaerosol, Foam [DPT Laboratories, Ltd.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 25 Aug 2009 05:00:00 +0100

Updated Date: Aug 25, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEsolution [Glenmark Generics Inc., USA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 25 Aug 2009 05:00:00 +0100

Updated Date: Aug 25, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEointment [Glenmark Generics Inc., USA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Fri, 21 Aug 2009 05:00:00 +0100

Updated Date: Aug 21, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effects of topical treatment with the raft modulator miltefosine and clobetasol in cutaneous mastocytosis: a randomized, double-blind, placebo-controlled trial

British Journal of Dermatology — Sun, 02 Aug 2009 23:00:00 +0100

Conclusions Raft modulators such as miltefosine are promising candidates for novel therapeutic strategies in patients with cutaneous mastocytosis. Future studies should be performed with improved formulations using nonirritant vehicles. (Source: British Journal of Dermatology)

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Refractory subacute cutaneous lupus erythematosus successfully treated with rituximab.

The Australasian Journal of Dermatology — Fri, 31 Jul 2009 23:00:00 +0100

Authors: Kieu V, O'Brien T, Yap LM, Baker C, Foley P, Mason G, Prince HM, McCormack C A 48-year-old woman presented with pruritic, scaly, annular plaques over her upper back and chest that were clinically, serologically and histologically characteristic of subacute cutaneous lupus erythematosus (SCLE). She failed to respond to conventional treatment, which included high-dose hydroxychloroquine, methotrexate, prednisolone, chloroquine, acitretin, thalidomide, dapsone and azathioprine. Subsequently treated with intravenous rituximab 375 mg/m(2) weekly for 4 weeks, she remained on adjuvant oral hydrochloroquine 600 mg daily and topical clobetasol propionate 0.05% ointment as required. Clearing of annular plaques was noted 8 weeks after the initial course of rituximab. By 12 weeks there we...

Refractory subacute cutaneous lupus erythematosus successfully treated with rituximab

Australasian Journal of Dermatology — Wed, 22 Jul 2009 23:00:00 +0100

A 48-year-old woman presented with pruritic, scaly, annular plaques over her upper back and chest that were clinically, serologically and histologically characteristic of subacute cutaneous lupus erythematosus (SCLE). She failed to respond to conventional treatment, which included high-dose hydroxychloroquine, methotrexate, prednisolone, chloroquine, acitretin, thalidomide, dapsone and azathioprine. Subsequently treated with intravenous rituximab 375 mg/m2 weekly for 4 weeks, she remained on adjuvant oral hydrochloroquine 600 mg daily and topical clobetasol propionate 0.05% ointment as required. Clearing of annular plaques was noted 8 weeks after the initial course of rituximab. By 12 weeks there were no new lesions and only post-inflammatory hyperpigmentation remained. Both hyper- and hyp...

CLOBETASOL PROPIONATEgel CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEointment [E. FOUGERA CO.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 30 Jun 2009 05:00:00 +0100

Updated Date: Jun 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Nanoencapsulation as a Way to Control the Release and to Increase the Photostability of Clobetasol Propionate: Influence of the Nanostructured System

Journal of Biomedical Nanotechnology — Fri, 26 Jun 2009 11:10:41 +0100

(Source: Journal of Biomedical Nanotechnology)

CLOBETASOL PROPIONATEgel [Glenmark Generics Inc., USA]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Wed, 24 Jun 2009 05:00:00 +0100

Updated Date: Jun 24, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

MedWorm Sponsor Message: Find the best January Sales in the UK.

CLOBETASOL PROPIONATEgel CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEointment [E. FOUGERA CO.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 23 Jun 2009 05:00:00 +0100

Updated Date: Jun 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

CLOBETASOL PROPIONATEsolution [E. FOUGERA CO.]

DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) — Tue, 23 Jun 2009 05:00:00 +0100

Updated Date: Jun 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Efficacy of topical tacrolimus 0.3% in clobetasol propionate 0.05% ointment in therapy-resistant cutaneous lupus erythematosus: a cohort study

Clinical And Experimental Dermatology — Sun, 21 Jun 2009 23:00:00 +0100

Conclusion. The results of our small retrospective study suggest that TCPO may be more effective than either 0.1% tacrolimus or clobetasol propionate 0.05% ointment monotherapy in the treatment of recalcitrant CLE. Randomized controlled trials are needed to confirm these preliminary findings. (Source: Clinical And Experimental Dermatology)

Clobevate (Clobetasol Propionate Gel) - new on RxList

RxList - New and Updated Drug Monographs — Tue, 05 May 2009 07:00:00 +0100

Clobevate (Clobetasol Propionate Gel) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

Effect of Intracanal Corticosteroids on Healing of Replanted Dog Teeth after Extended Dry Times

Journal of Endodontics — Fri, 01 May 2009 04:00:00 +0100

This study investigated the effect of potent intracanal corticosteroids on periodontal healing of replanted avulsed teeth and evaluated the systemic absorption of these corticosteroids. Sixty-seven extracted dog premolar roots were randomly assigned to one of the following groups: groups 1–3 filled with gutta-percha and replanted immediately and after 40 and 60 minutes, respectively; groups 4 and 5 filled with 0.05% clobetasol; and groups 6 and 7 filled with 0.05 % fluocinonide. Groups 4 and 6 were replanted after 40 minutes and groups 5 and 7 after 60 minutes. After 4 months, roots were evaluated histologically for signs of periodontal healing. Roots treated with clobetasol and fluocinonide healed more favorably than roots filled with gutta-percha and were different from each other at 6...

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[Efficacy of rituximab in a case of refractory bullous pemphigoid]

Annales de Dermatologie et de Cenereologie — Thu, 30 Apr 2009 23:00:00 +0100

CONCLUSION: Rituximab could offer a safe and effective therapeutic alternative for refractory BP. PMID: 19442800 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)

Melanocytic proliferations associated with lichen sclerosus in adolescence

Archives of Gynecology and Obstetrics — Sat, 28 Mar 2009 08:55:27 +0100

In this report, we describe the case of a prepubertal girl presenting with a junctional melanocytic nevus of the labia minora superimposed by lichen sclerosus. The lesion was completely excised and free margins confirmed by histological examination. After a 3 months course of topical clobetasol treatment the girl remained asymptomatic. No local recurrence was notified with a follow-up time of 12 months. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1049-5Authors Stefanie Susanne Bussen, Women’s University Hospital of Mannheim Rathausstr. 25 68519 Viernheim Germany Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

Docetaxel: Dermatitis treated with clobetasol: case report

Reactions — Tue, 17 Mar 2009 08:38:10 +0100

(Source: Reactions)

Docetaxel: Dermatitis treated with clobetasol: case report.

Reactions Weekly — Sun, 15 Mar 2009 03:38:56 +0100

Page: 20 (Source: Reactions Weekly)