MedWorm: Academies

National Fire Academy Educational Program

Grants.gov — Sat, 20 Mar 2010 15:15:32 +0100

Funding Opportunity Number: DHS-10-USFA-019-000-01 Opportunity Category: DiscretionaryFunding Instrument Type: GrantCategory of Funding Activity: Other (see text field entitled "Explanation of Other Category of Funding Activity" for clarification)CFDA Number: 97.019Eligible Applicants Private institutions of higher educationAgency Name DHS-DHS (Source: Grants.gov)

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AMA Supports Latest Healthcare Reform Legislation With Reservations

Medscape Today Headlines — Sat, 20 Mar 2010 10:08:49 +0100

The American College of Physicians and the American Academy of Pediatrics also are backing the reform bill slated for a House vote on Sunday. Medscape Medical News (Source: Medscape Today Headlines)

Scientists Study Dancing Babies ... Enough Said?

NPR Health and Science — Fri, 19 Mar 2010 17:00:00 +0100

In perhaps the cutest study published in the Proceedings of the National Academy of Sciences, psychologist Marcel Zentner and Tuomas Eerola found that babies will spontaneously groove to music. While babies are not great dancers, they smile more when they do hit the beat.» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)

Platelet-Rich Plasma Shows Promise but Results Vary Widely

Medscape Today Headlines — Fri, 19 Mar 2010 16:52:18 +0100

In 4 studies highlighted at this year's American Academy of Orthopaedic Surgeons annual meeting, platelet-rich plasma either worked like a charm or failed totally. Medscape Medical News (Source: Medscape Today Headlines)

Robert H. Williams distinguished leadership award 2011

Fri, 19 Mar 2010 16:42:04 +0100

To honour outstanding leadership in fundamental or clinical endocrinology. Description: This award is presented in recognition of outstanding leadership in fundamental or clinical endocrinology as exemplified by the recipient's contributions, and those of his/her trainees and associates, to teaching, research, and administration. The award includes an honorarium of $5,000. Comments: The nomination deadline is 1st April 2010. For further information see their website. Restrictions: All nominations must be submitted by an Active Member or Emeritus Member of The Endocrine Society. Closing date for applications: Thursday 1st April 2010 (Source: Funding Opportunities list from the Higher Education Academy Subject Centre for Medicine, Dentistry and Veterinary Medicine)

Distinguished educator award 2011

Fri, 19 Mar 2010 16:42:03 +0100

To recognise exceptional achievement as an educator in the discipline of endocrinology and metabolism. This award is presented in recognition of exceptional achievement as an educator in the discipline of endocrinology and metabolism. Funding: The award includes an honorarium of $3,000. Comments: The nomination deadline is 1st April 2010. For further information see their website. Restrictions: All nominations must be submitted by an Active Member or Emeritus Member of The Endocrine Society. Closing date for applications: Thursday 1st April 2010 Contact: laureate@endo-society.org (Source: Funding Opportunities list from the Higher Education Academy Subject Centre for Medicine, Dentistry and Veterinary Medicine)

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Festival of learning 2010: the way forward with education in health professions

MEDEV Events — Fri, 19 Mar 2010 16:42:01 +0100

The Festival of Learning is an innovative concept developed by the Higher Education Academy Health Sciences and Practice Subject Centre. It is held annually each time in a different UK location.The eighth Festival of Learning will be hosted by the Edinburgh Napier University at their beautiful Craighouse campus. The Festival blends elements of established event formats - high profile keynote presentations, workshops, special interest groups - to provide a unique celebration of diverse approaches to education and training in the Health Sciences. This year, the Festival 2010, will focus on the three themes as follows: Making connection - Assimilating theory and practice; developing partnerships between the NHS and HEIs and also education and employers; aiding awareness of educational pol...

Better Methods to Measure, Verify Greenhouse Gas Emissions Needed

News from the National Academies — Fri, 19 Mar 2010 15:24:36 +0100

Countries can inventory their carbon dioxide emissions from fossil-fuel use accurately enough to support monitoring of an international climate change treaty, but currently there is no sufficiently accurate way to verify countries' self-reported estimates using independent data, says a new report from the National Research Council. Strategic investments could, within five years, improve countries' self-reported emissions estimates and yield the capability to verify them. (Source: News from the National Academies)

Intratympanic gentamicin treatment of patients with Ménière's disease with normal hearing

Otolaryngology - Head and Neck Surgery — Fri, 19 Mar 2010 15:22:36 +0100

Conclusions: Patients with stage 1 Ménière's disease appear to have similar vertigo control with better hearing preservation than patients with advanced disease when treated with low-dose intratympanic gentamicin (10 mg/mL). (Source: Otolaryngology - Head and Neck Surgery)

WMIG Update

Medscape Emergency Medicine Headlines — Fri, 19 Mar 2010 15:15:22 +0100

As a female physician, what do you do if patients mistake you for a nurse? American Academy of Emergency Medicine (Source: Medscape Emergency Medicine Headlines)

Scientists side with smelt, salmon protections

Los Angeles Times - Science — Fri, 19 Mar 2010 07:00:00 +0100

A panel with the National Academy of Sciences says measures taken to save the fish that have also curbed water supplies from the Sacramento-San Joaquin delta are scientifically justified. A National Academy of Sciences panel has concluded that the much-disputed fish protections that have curbed water deliveries to the San Joaquin Valley and Southern California are scientifically justified. (Source: Los Angeles Times - Science)

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Teaching medical students about chronic disease: patient-led teaching in rheumatoid arthritis

Musculoskeletal Care — Fri, 19 Mar 2010 00:00:00 +0100

Conclusions: We have demonstrated that our patient was at least as good as a doctor at teaching about the impact of chronic disease on patients. Furthermore, this experience is valued by students who appreciate the personal insight that a patient can offer. Copyright © 2010 John Wiley & Sons, Ltd. (Source: Musculoskeletal Care)

Injectable Polymer Corrects Wrinkles Better Than Collagen

Modern Medicine — Fri, 19 Mar 2010 00:00:00 +0100

Injectable poly-L-lactic acid, a synthetic, biodegradable, biocompatible polymer device, is more effective in correcting nasolabial fold wrinkles than collagen, with effects observed as long as 25 months after the last treatment, according to a study in the March issue of the Journal of the American Academy of Dermatology. (Source: Modern Medicine)

Article Evaluates Options for Non-Motor Parkinson's Issues

Modern Medicine — Fri, 19 Mar 2010 00:00:00 +0100

Several medications may be helpful in treating such non-motor symptoms of Parkinson's disease as erectile dysfunction and constipation, but there is insufficient evidence for certain treatments for other issues such as anxiety and urinary incontinence, according to an American Academy of Neurology practice parameter published in the March 16 issue of Neurology. (Source: Modern Medicine)

From Tales of the Field to Tales of the Future

Organizational Research Methods — Thu, 18 Mar 2010 22:55:02 +0100

John Van Maanen’s account of the evolution of ethnographic narratives provided far more than insight about classic anthropological and sociological texts. By encouraging qualitative researchers to focus on the rhetorical and political qualities of voice, style, authority, and representations of selves and others, he exposed the often hidden assumptions built into fieldwork and scholarship. It is not too much to say that no other single text has so forcefully shaped and inspired our understanding of qualitative research and narrative writing across the social sciences. Van Maanen’s work inspired two cross-disciplinary projects. One charted the cultural, rhetorical, and narrative influences that constructed classic ethnographic texts; the other created a common cultural code for ...

Leading US Speakers Confirmed For 2010 British Dental Conference And Exhibition

Health News from Medical News Today — Thu, 18 Mar 2010 18:00:00 +0100

Leading US clinical speakers David Newkirk and William Bo Bruce are to headline the Friday lecture programme at the 2010 British Dental Conference and Exhibition. Both are renowned experts in the field of restorative and aesthetic dentistry and are accredited members of the American Academy of Cosmetic Dentistry. William Bo Bruce is Affiliate Assistant Professor at the Medical University of South Carolina College of Dental Medicine. David Newkirk is a general dental practitioner in Naperville Illinois... (Source: Health News from Medical News Today)

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Leading US Speakers Confirmed For 2010 British Dental Conference And Exhibition

Dentistry News From Medical News Today — Thu, 18 Mar 2010 18:00:00 +0100

Mo'Nique's Open Marriage

Psychology Today Relationships Center — Thu, 18 Mar 2010 17:06:25 +0100

Just when you think you have heard it all, along comes Mo'Nique! Here is what she says about her marriage to Sid -- "Could Sid have sex outside of his marriage with me? Yes. That's not a deal-breaker," she says. "That's not something that would make us say, 'Pack your things and let's end the marriage.'"And according to US.Magazine.com she says "she wouldn't call it quits even if he had numerous flings."We are sorry Mo'Nique but you are sending a terrible message to those who are married - to those who are in love. Trust us when we say this - you are plain wrong and your message is not supported by any research on successful marriage!We have interviewed successfully married couples in over 40 countries of the world for 27+ years. And here's the deal - we find absolutely no support for her ...

Public engagement society awards

Thu, 18 Mar 2010 15:48:37 +0100

To encourage people of all ages and walks of life to learn about these developments and have an opportunity to consider, question and debate the implications and issues arising from such work. By inspiring, informing and involving whole communities, Society Awards enable people to consider and discuss issues that affect them, those close to them and the world in which they live. Description: Projects should aim to achieve at least one of the following: * stimulate interest, excitement and debate about biomedical science through various methods * examine the social, cultural, historical and ethical impact of biomedical science * encourage new ways of thinking about biomedical science. In October each year they accept pre-proposals only on a selected theme. The theme for the 2009 Wellcome ...

Higher Education student volunteering awards

Thu, 18 Mar 2010 15:48:37 +0100

We are delighted to announce that HESVA 2010 is now open for entries. The Awards celebrate the diversity of the student learning experience and recognise the outstanding contributions to community volunteering made by students in higher education across the UK. As part of the Academy's UK-wide remit, HESVA is open to all UK higher education institutions. It is also open to further education institutions with 100 or more full-time equivalent students in England and Northern Ireland. Scottish or Welsh FE Colleges may submit a joint nomination with a sponsoring higher education institution. Entries can be submitted across two categories: * Student Volunteering Awards (up to two entries per institution) * Outstanding Project Awards (one entry per institution). Fifteen awards are available...

The Mullard Award

Thu, 18 Mar 2010 15:48:37 +0100

To honour an individual who has an outstanding academic record in any area of natural science, engineering or technology and whose work is currently making a contribution to national prosperity in the United Kingdom. The award is made annually by the Council of the Royal Society to honour an individual who has an outstanding academic record. The award will be presented at the Society's Anniversary Day, or on another suitable occasion. Nominations for the award are invited from all Fellows of the Society, research institutions and Industry. A silver gilt medal, a prize of £2000 and a travel/conference grant of up to £1500 (Estimated total funds: £3,500) Closing Date: 01 April 2010 Nominations are now being accepted. The closing date is 1st April 2010. Please see website for applicati...

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Educating Medical Students in Laboratory Medicine: A Proposed Curriculum.

American Journal of Clinical Pathology — Thu, 18 Mar 2010 15:41:11 +0100

Authors: Smith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Bock JL, Campbell S, Crookston KP, Fitzgerald R, Fung M, Haspel R, Howe JG, Jhang J, Kamoun M, Koethe S, Krasowski MD, Landry ML, Marques MB, Rinder HM, Roberts W, Schreiber WE, Spitalnik SL, Tormey CA, Wolf P, Wu YY, As the 100th anniversary of the Flexner report nears, medical student education is being reviewed at many levels. One area of concern, expressed in recent reports from some national health care organizations, is the adequacy of training in the discipline of laboratory medicine (also termed clinical pathology). The Academy of Clinical Laboratory Physicians and Scientists appointed an ad hoc committee to review this topic and to develop a suggested curriculum, which was subsequently forwarded to the entire...

Federal Actions to Protect Fishes in California Bay-Delta Found 'Scientifically Justified'

News from the National Academies — Thu, 18 Mar 2010 14:35:48 +0100

Most of the actions proposed by two federal agencies to protect endangered and threatened fish species through water diversions in the California Bay-Delta are "scientifically justified," but less well-supported by scientific analyses is the basis for the specific environmental triggers that would indicate when to reduce the water diversions required by the actions, says a new report from the National Research Council. (Source: News from the National Academies)

A bleak outlook for social science?

EurekAlert! - Social and Behavioral Science — Thu, 18 Mar 2010 04:00:00 +0100

(SAGE Publications UK) Social science is at the center of every major challenge the world faces, yet faces a tough future, according to a panel of senior academics and politicians speaking in London this week. They were taking part in a debate hosted by the British Academy and SAGE to explore how social science research can strengthen its involvement in policy-making, increase its impact, and combat potential public expenditure cuts. (Source: EurekAlert! - Social and Behavioral Science)

UCLA medical students brace for news at residency 'Match Day'

UCLA Newsroom: Health Sciences — Wed, 17 Mar 2010 19:02:00 +0100

WHAT: Match Day is the fun, frenzied day when medical students nationwide learn which hospital has accepted them for residency — advanced training in their chosen specialty. At UCLA, the ceremony climaxes in a mad scramble for the envelopes, with 150 aspiring doctors tearing them open with their families and friends. Many videotape themselves and let distant loved ones listen in on cell phones during this emotional rollercoaster of an event. WHEN: Thursday, March 18 8 a.m.: Students and families arrive for check-in and breakfast. 8:30 a.m.: Welcome by Dr. Neil Parker, senior associate dean of student affairs at the David Geffen School of Medicine at UCLA. 9 a.m.: Students at UCLA (and across the country) open their envelopes. WHERE: Covel ...

PNAS: 18F-FDG-PET could ID maternal family link to Alzheimer’s disease

Health Imaging News — Wed, 17 Mar 2010 16:26:42 +0100

18F-FDG PET identified the average increase amyloid-beta plaques among individuals whose mothers had been diagnosed with Alzheimer’s disease compared to others with no family history of dementia, according to research findings published online March 15 in the Proceedings of the National Academy of Sciences. (Source: Health Imaging News)

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PNAS: 18F-FDG-PET could ID maternal family link to Alzheimer’s disease

Health Imaging News — Wed, 17 Mar 2010 16:26:42 +0100

Overexpression of c-erbB-2 and loss of p16 have molecular diagnostic relevance but no prognostic value in lung cancer

Medical Oncology — Wed, 17 Mar 2010 15:51:54 +0100

This study was designed to evaluate the expression of C-erbB-2 and p16 in lung cancers using tissue microarray technology and to determine their clinical and pathological significance. Immunohistochemical C-erbB-2 and p16 expressions and their associations with clinical and pathological features were analyzed in two tissue microarrays. The membranous and cytoplasmic expression rates of C-erbB-2 were 40.5 and 66.5% in non-small cell lung cancers (NSCLCs), and 0 and 9.5% in small cell lung cancers (SCLCs), respectively. The nuclear and cytoplasmic expression rates of p16 were 11.5 and 32.2% in NSCLs, and 45 and 80% in SCLCs, respectively. The cytoplasmic expression of both C-erbB-2 and p16 was more frequent than the membranous expression of C-erbB-2 and the nuclear expression of p16. T...

Developing and enhancing the practice and management of scholarly activity and research within further education colleges

MEDEV Events — Wed, 17 Mar 2010 15:48:00 +0100

The Higher Education Academy will be holding two more events to support practitioners to engage with scholarly activity/research and to allow managers to receive information in regard to successfully managing it within their institutions. These events will address key issues for both practitioners and managers within FECs involved with research / scholarly activity, such as: i. the meaning of scholarly activity/research and how to build a research ethos; ii. the key research processes, including research design/dissemination; iii. making funding applications; iv. key resources to support their engagement with scholarly activity; v. considerations for and management of scholarly activity/research within an FEC; vi. institutional impacts from Scholarly Activity / research. The workshops wi...

Working with Students to Enhance Feedback

MEDEV Events — Wed, 17 Mar 2010 15:48:00 +0100

This meeting has been organised jointly between the Higher Education Academy and the NUS to look at ways in which staff and students can work together to enhance assessment and feedback. It aims to facilitate discussion of issues and identify good practice relating to assessment and feedback. It is open to practitioners, researchers and managers with an interest in this area. Bookings will only be accepted from institutions that send both a staff and student/Student Union representative. (Source: MEDEV Events)

Bursaries

Wed, 17 Mar 2010 15:48:00 +0100

for undergraduate elective or vacation studies 2010. The Royal College of Surgeons of Edinburgh is offering a number of bursaries to undergraduate students of medicine or dentistry to enable them to work for elective or vacation periods in universities, medical schools, NHS laboratories or research institutes in the United Kingdom. Proposals for work on research projects in any branch of surgery are eligible for consideration. The bursary will be up to £150 per week for a maximum of 8 weeks. Up to £300 is also available for consumables. Comments: The closing date for applications is 31st March 2010. Applications must be submitted on the official Royal College of Surgeons of Edinburgh application form. An electronic version of Part A must be sent to the Awards and Grants Secretary, ...

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Double accolade from Academy of Social Sciences

University of Bristol news — Wed, 17 Mar 2010 15:12:21 +0100

Two academics from the Faculty of Social Sciences and Law have achieved the distinction of being elected Academicians of the Academy of Social Sciences. (Source: University of Bristol news)

Advocate: Not Just for Your Patients, But also for Your Specialty

Medscape Today Headlines — Wed, 17 Mar 2010 15:04:30 +0100

Why should you join a specialty organization? American Academy of Emergency Medicine (Source: Medscape Today Headlines)

Human Origins Exhibit Opens

News from the National Academies — Wed, 17 Mar 2010 14:17:40 +0100

The Smithsonian Institution's National Museum of Natural History has opened a new exhibit dedicated to the discovery and understanding of human origins. The National Academy of Sciences consulted on the project and is a partner institution for the exhibit. On March 31, the Smithsonian will host a lecture about a recent National Research Council report, Understanding Climate's Influence on Human Evolution (Source: News from the National Academies)

Mammalian Regeneration Through A Single Gene Deletion Demonstrated By Wistar Scientists

Health News from Medical News Today — Wed, 17 Mar 2010 08:00:00 +0100

A quest that began over a decade ago with a chance observation has reached a milestone: the identification of a gene that may regulate regeneration in mammals. The absence of this single gene, called p21, confers a healing potential in mice long thought to have been lost through evolution and reserved for creatures like flatworms, sponges, and some species of salamander. In a report published in the Proceedings of the National Academy of Sciences, researchers from The Wistar Institute demonstrate that mice that lack the p21 gene gain the ability to regenerate lost or damaged tissue... (Source: Health News from Medical News Today)

New Survey From The American Academy Of Cosmetic Surgery Reveals More Than 17 Million Cosmetic Procedures Performed Last Year In The U.S.

Health News from Medical News Today — Wed, 17 Mar 2010 08:00:00 +0100

A procedural survey conducted by the American Academy of Cosmetic Surgery (AACS) says more than 17 million cosmetic surgery procedures were performed in the United States in 2009. The total number of procedures from this first-time study far surpasses any number that has been previously reported in the U.S. This is the first nationwide survey of its kind done by the AACS. In addition to the annual polling of its own members, the AACS also surveyed random physicians across the country to find out who is performing cosmetic surgery procedures... (Source: Health News from Medical News Today)

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Identification Of Gene That May Play A Key Role In Atherosclerosis And Other Diseases

Health News from Medical News Today — Wed, 17 Mar 2010 08:00:00 +0100

To understand the role of inflammation in cardiovascular and other diseases, it is essential to identify and characterize genes that induce an inflammatory response in the body -- and the genes that regulate them. A study published online this week in the journal Proceedings of the National Academy of Sciences suggests that a gene called Hu antigen R (HuR) plays a critical role in inducing and mediating an inflammatory response in cells experiencing mechanical and chemical stresses. The study was supported by the National Institutes of Health... (Source: Health News from Medical News Today)

New Survey From The American Academy Of Cosmetic Surgery Reveals More Than 17 Million Cosmetic Procedures Performed Last Year In The U.S.

Cosmetic Medicine / Plastic Surgery News From Medical News Today — Wed, 17 Mar 2010 08:00:00 +0100

A procedural survey conducted by the American Academy of Cosmetic Surgery (AACS) says more than 17 million cosmetic surgery procedures were performed in the United States in 2009. The total number of procedures from this first-time study far surpasses any number that has been previously reported in the U.S. This is the first nationwide survey of its kind done by the AACS... (Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today)

Science is the engine of growth

Guardian Unlimited Science — Wed, 17 Mar 2010 00:05:09 +0100

I read with interest your leader about National Science and Engineering Week (Festivities and the aversion of famine, 15 March). Support for scientific and medical research has never been higher, according to a report issued last week by the Wellcome Trust. Virtually all (95%) of respondents to the survey thought that medical research should be supported and encouraged, even if a lot of public money would need to be invested. The report also challenges the myth that young people in particular are turned off by science, with 81% expressing an interest and 44% considering science as a career.Science and innovation will be crucial to helping revitalise the British economy. It is up to the scientific community as well as government to ensure that the public is kept informed and engaged �...

Level of Sedation with Nitrous Oxide for Pediatric Medical Procedures.

Anesthesia and Analgesia — Wed, 17 Mar 2010 00:00:00 +0100

Conclusions: A significant number of children remain minimally sedated while receiving N(2)O at concentrations >50% via nasal hood using a system designed to titrate N(2)O concentration from 0% to 70%. Adverse event rates of patients receiving >50% N(2)O in this manner are similar to rates reported in large studies of 50% N(2)O administration. PMID: 20237043 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)

AAFP is 'Pawn' in Health Care Reform; Academy Responds 'Not So'

As We See It: Voices From the AAFP — Tue, 16 Mar 2010 22:45:00 +0100

As someone who has been involved with advocacy for many years, I'm writing to express my brutal disappointment in the Academy's positioning and effectiveness in the recent health care debate. (Source: As We See It: Voices From the AAFP)

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Lack of linguistic support for Proto-Uto-Aztecan at 8900 BP [Letters]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:07 +0100

(Source: Proceedings of the National Academy of Sciences)

Reply to Hill and Brown: Maize and Uto-Aztecan cultural history [Letters]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:07 +0100

(Source: Proceedings of the National Academy of Sciences)

Reply to Rocke and Barker: The question is not whether birds are affected by thiamine deficiency or botulism, it is about the order of events [Letters]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:07 +0100

(Source: Proceedings of the National Academy of Sciences)

Revision of the mtDNA tree and corresponding haplogroup nomenclature [Letters]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:07 +0100

(Source: Proceedings of the National Academy of Sciences)

Reply to van Oven: Suggestions and caveats for naming mtDNA haplogroup [Letters]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:07 +0100

(Source: Proceedings of the National Academy of Sciences)

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New evidence for a Mesoamerican homeland for Proto-Uto-Aztecan [Letters]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

(Source: Proceedings of the National Academy of Sciences)

In vivo vomeronasal stimulation reveals sensory encoding of conspecific and allospecific cues by the mouse accessory olfactory bulb [Neuroscience]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

The rodent vomeronasal system plays a critical role in mediating pheromone-evoked social and sexual behaviors. Recent studies of the anatomical... (Source: Proceedings of the National Academy of Sciences)

Reduced voltage sensitivity in a K+-channel voltage sensor by electric field remodeling [Neuroscience]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

Propagation of the nerve impulse relies on the extreme voltage sensitivity of Na+ and K+ channels. The transmembrane movement of... (Source: Proceedings of the National Academy of Sciences)

Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host [Neuroscience]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

How grafted neural stem cells (NSCs) and their progeny integrate into recipient brain tissue and functionally interact with host cells... (Source: Proceedings of the National Academy of Sciences)

Kinetics of brain nicotine accumulation in dependent and nondependent smokers assessed with PET and cigarettes containing 11C-nicotine [Neuroscience]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

Tobacco smoking is a chronic, relapsing disorder that constitutes one of the primary preventable causes of death in developed countries.... (Source: Proceedings of the National Academy of Sciences)

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Distal axonopathy with structural persistence in glaucomatous neurodegeneration [Neuroscience]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

An early hallmark of neuronal degeneration is distal transport loss and axon pathology. Glaucoma involves the degeneration of retinal ganglion... (Source: Proceedings of the National Academy of Sciences)

Axon guidance by growth-rate modulation [Neuroscience]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

Guidance of axons by molecular gradients is crucial for wiring up the developing nervous system. It often is assumed that... (Source: Proceedings of the National Academy of Sciences)

Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice [Physiology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

Glucose homeostasis is critically dependent on insulin release from pancreatic β-cells, which is strictly regulated by glucose-induced oscillations in membrane... (Source: Proceedings of the National Academy of Sciences)

A developmental framework for endodermal differentiation and polarity [Plant_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

The endodermis is a root cell layer common to higher plants and of fundamental importance for root function and nutrient... (Source: Proceedings of the National Academy of Sciences)

Polar localization and degradation of Arabidopsis boron transporters through distinct trafficking pathways [Plant_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

Boron (B) is essential for plant growth but is toxic when present in excess. In the roots of Arabidopsis thaliana... (Source: Proceedings of the National Academy of Sciences)

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Phosphoenolpyruvate carboxylase intrinsically located in the chloroplast of rice plays a crucial role in ammonium assimilation [Plant_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

Phosphoenolpyruvate carboxylase (PEPC) is a key enzyme of primary metabolism in bacteria, algae, and vascular plants, and is believed to... (Source: Proceedings of the National Academy of Sciences)

Optimal reward harvesting in complex perceptual environments [Psychological_And_Cognitive_Sciences-BS]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

The ability to choose rapidly among multiple targets embedded in a complex perceptual environment is key to survival. Targets may... (Source: Proceedings of the National Academy of Sciences)

Human face recognition ability is specific and highly heritable [Psychological_And_Cognitive_Sciences-BS]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

Compared with notable successes in the genetics of basic sensory transduction, progress on the genetics of higher level perception and... (Source: Proceedings of the National Academy of Sciences)

Ecosystem service bundles for analyzing tradeoffs in diverse landscapes [Sustainability_Science-BS]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

A key challenge of ecosystem management is determining how to manage multiple ecosystem services across landscapes. Enhancing important provisioning ecosystem... (Source: Proceedings of the National Academy of Sciences)

Theta-activity in anterior cingulate cortex predicts task rules and their adjustments following errors [Systems_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

Accomplishing even simple tasks depend on neuronal circuits to configure how incoming sensory stimuli map onto responses. Controlling these stimulus-response... (Source: Proceedings of the National Academy of Sciences)

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Dynamic transcriptomes during neural differentiation of human embryonic stem cells revealed by short, long, and paired-end sequencing [Systems_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

To examine the fundamental mechanisms governing neural differentiation, we analyzed the transcriptome changes that occur during the differentiation of hESCs... (Source: Proceedings of the National Academy of Sciences)

Correction for Levy et al., Eye movement evidence that readers maintain and act on uncertainty about past linguistic input [errata]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

(Source: Proceedings of the National Academy of Sciences)

Correction for Orans et al., Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility [errata]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

(Source: Proceedings of the National Academy of Sciences)

Correction for Budzik et al., Intramolecular amide bonds stabilize pili on the surface of bacilli [errata]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

(Source: Proceedings of the National Academy of Sciences)

Retraction for Cannata et al., Triplex-forming oligonucleotide-orthophenanthroline conjugates for efficient targeted genome modification [Retractions]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:06 +0100

(Source: Proceedings of the National Academy of Sciences)

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Functional analysis of human mismatch repair gene mutations identifies weak alleles and polymorphisms capable of polygenic interactions [Genetics]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Many of the mutations reported as potentially causing Lynch syndrome are missense mutations in human mismatch repair (MMR) genes. Here,... (Source: Proceedings of the National Academy of Sciences)

Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency [Genetics]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Nuclear lamins are components of the nuclear lamina, a structural scaffolding for the cell nucleus. Defects in lamins A and... (Source: Proceedings of the National Academy of Sciences)

A genome-wide association study of alcohol dependence [Genetics]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Excessive alcohol consumption is one of the leading causes of preventable death in the United States. Approximately 14% of those... (Source: Proceedings of the National Academy of Sciences)

Seromic profiling of ovarian and pancreatic cancer [Immunology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Autoantibodies, a hallmark of both autoimmunity and cancer, represent an easily accessible surrogate for measuring adaptive immune responses to cancer.... (Source: Proceedings of the National Academy of Sciences)

Evidence for a functional sidedness to the {alpha}{beta}TCR [Immunology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

The T cell receptor (TCR) and associated CD3, , and signaling dimers allow T cells to discriminate between different... (Source: Proceedings of the National Academy of Sciences)

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Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes [Immunology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Many well-known immune-related C-type lectin-like receptors (CTLRs) such as NKG2D, CD69, and the Ly49 receptors are encoded in the natural... (Source: Proceedings of the National Academy of Sciences)

Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents [Medical_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Mice that accurately model the genetic diversity found in human cancer are valuable tools for interrogating disease mechanisms and investigating... (Source: Proceedings of the National Academy of Sciences)

From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway [Medical_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Inhibition of blood vessel formation is a viable therapeutic approach in angiogenesis-dependent diseases. We previously used a combinatorial screening on... (Source: Proceedings of the National Academy of Sciences)

From combinatorial peptide selection to drug prototype (II): Targeting the epidermal growth factor receptor pathway [Medical_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

The epidermal growth factor receptor (EGFR), a tyrosine kinase, is central to human tumorigenesis. Typically, three classes of drugs inhibit... (Source: Proceedings of the National Academy of Sciences)

Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease [Medical_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Understanding the pathogenesis of cancer-related bone disease is crucial to the discovery of new therapies. Here we identify activin A,... (Source: Proceedings of the National Academy of Sciences)

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Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure [Medical_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Recent advances in high-field (≥7 T) MRI have made it possible to study the fine structure of the human brain... (Source: Proceedings of the National Academy of Sciences)

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy [Medical_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

The Wnt/β-catenin signaling pathway is activated in breast cancer, a leading cause of cancer mortality in women. Because mutations in... (Source: Proceedings of the National Academy of Sciences)

Allele-specific tumor spectrum in Pten knockin mice [Medical_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Germline mutations in the tumor suppressor gene PTEN (phosphatase and tensin homology deleted on chromosome 10) cause Cowden and Bannayan–Riley–Ruvalcaba... (Source: Proceedings of the National Academy of Sciences)

Pain perception is altered by a nucleotide polymorphism in SCN9A [Medical_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

The gene SCN9A is responsible for three human pain disorders. Nonsense mutations cause a complete absence of pain, whereas activating... (Source: Proceedings of the National Academy of Sciences)

Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis [Microbiology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Bacterial nucleoid-associated proteins play important roles in chromosome organization and global gene regulation. We find that Lsr2 of Mycobacterium tuberculosis... (Source: Proceedings of the National Academy of Sciences)

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A link between the assembly of flagella and lipooligosaccharide of the Gram-negative bacterium Campylobacter jejuni [Microbiology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Campylobacter jejuni is the leading cause of acute bacterial diarrhea worldwide and is implicated in development of Guillain-Barré syndrome. Two... (Source: Proceedings of the National Academy of Sciences)

Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors [Microbiology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:05 +0100

Xenotropic murine leukemia virus-related virus (XMRV) is a recently discovered gammaretrovirus that has been linked to prostate cancer and chronic... (Source: Proceedings of the National Academy of Sciences)

A ratchet mechanism for amplification in low-frequency mammalian hearing [Biophysics_And_Computational_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

The sensitivity and frequency selectivity of hearing result from tuned amplification by an active process in the mechanoreceptive hair cells.... (Source: Proceedings of the National Academy of Sciences)

Random cell movement promotes synchronization of the segmentation clock [Biophysics_And_Computational_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

In vertebrate somitogenesis, the expression of segmentation clock genes oscillates and the oscillation is synchronized over nearby cells. Both experimental... (Source: Proceedings of the National Academy of Sciences)

Minute negative superhelicity is sufficient to induce the B-Z transition in the presence of low tension [Biophysics_And_Computational_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

Left-handed Z-DNA has fascinated biological scientists for decades by its extraordinary structure and potential involvement in biological phenomena. Despite its... (Source: Proceedings of the National Academy of Sciences)

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Strong intranucleoid interactions organize the Escherichia coli chromosome into a nucleoid filament [Biophysics_And_Computational_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

The stochasticity of chromosome organization was investigated by fluorescently labeling genetic loci in live Escherichia coli cells. In spite of... (Source: Proceedings of the National Academy of Sciences)

CaV1.2 {beta}-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations [Biophysics_And_Computational_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and heart failure, but the cellular mechanisms for CaMKII-targeted proteins causing... (Source: Proceedings of the National Academy of Sciences)

Atomically detailed simulation of the recovery stroke in myosin by Milestoning [Biophysics_And_Computational_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

Myosin II is a molecular motor that converts chemical to mechanical energy and enables muscle operations. After a power stroke,... (Source: Proceedings of the National Academy of Sciences)

Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs [Cell_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

Initiation of DNA replication in eukaryotic cells is controlled through an ordered assembly of protein complexes at replication origins. The... (Source: Proceedings of the National Academy of Sciences)

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells [Cell_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

Aberrant activation of Notch receptors has been implicated in breast cancer; however, the mechanisms contributing to Notch-dependent transformation remain elusive... (Source: Proceedings of the National Academy of Sciences)

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Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin [Cell_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a neurodegenerative disorder of unknown etiology. Parkin has... (Source: Proceedings of the National Academy of Sciences)

Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus [Developmental_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

High levels of unconjugated bilirubin (UCB) in newborn children is associated with a reduction in hepatic UDP glucuronosyltransferase (UGT) 1A1... (Source: Proceedings of the National Academy of Sciences)

Macroecological signals of species interactions in the Danish avifauna [Ecology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

The role of intraspecific and interspecific interactions in structuring biotic communities at fine spatial scales is well documented, but the... (Source: Proceedings of the National Academy of Sciences)

Tropical cloud forest climate variability and the demise of the Monteverde golden toad [Environmental_Sciences-PS]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

Widespread amphibian extinctions in the mountains of the American tropics have been blamed on the interaction of anthropogenic climate change... (Source: Proceedings of the National Academy of Sciences)

Population genetics of ecological communities with DNA barcodes: An example from New Guinea Lepidoptera [Evolution]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

Comparative population genetics of ecological guilds can reveal generalities in patterns of differentiation bearing on hypotheses regarding the origin and... (Source: Proceedings of the National Academy of Sciences)

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A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression [Evolution]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

During the course of evolution, a massive reduction of the mitochondrial genome content occurred that was associated with transfer of... (Source: Proceedings of the National Academy of Sciences)

Complete mitochondrial genome of a Pleistocene jawbone unveils the origin of polar bear [Evolution]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

The polar bear has become the flagship species in the climate-change discussion. However, little is known about how past climate... (Source: Proceedings of the National Academy of Sciences)

Polygenic and directional regulatory evolution across pathways in Saccharomyces [Evolution]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

The search to understand how genomes innovate in response to selection dominates the field of evolutionary biology. Powerful molecular evolution... (Source: Proceedings of the National Academy of Sciences)

Evolution of species-specific promoter-associated mechanisms for protecting chromosome ends by Drosophila Het-A telomeric transposons [Genetics]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:04 +0100

The non-LTR retrotransposons forming Drosophila telomeres constitute a robust mechanism for telomere maintenance, one which has persisted since before separation... (Source: Proceedings of the National Academy of Sciences)

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

Pregnancy-associated malaria (PAM) is a serious consequence of sequestration of Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to... (Source: Proceedings of the National Academy of Sciences)

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Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

Cisplatin is one of the most commonly used anticancer drugs. It kills cancer cells by damaging their DNA, and hence... (Source: Proceedings of the National Academy of Sciences)

Pore architecture of the ORAI1 store-operated calcium channel [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

ORAI1 is the pore-forming subunit of the calcium release-activated calcium (CRAC) channel, a store-operated channel that is central to Ca2+... (Source: Proceedings of the National Academy of Sciences)

The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

p73, the structural and functional homologue of p53, exists as two major forms: the transactivation-proficient, proapoptotic TAp73 or the transactivation-deficient,... (Source: Proceedings of the National Academy of Sciences)

Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

The Gibbs free energy difference between native and unfolded states ("stability") is one of the fundamental characteristics of a protein.... (Source: Proceedings of the National Academy of Sciences)

Engineering cis-telomerase RNAs that add telomeric repeats to themselves [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

Telomerase is a ribonucleoprotein complex consisting of a protein reverse transcriptase (TERT) and an RNA subunit (TR). Telomerase normally adds... (Source: Proceedings of the National Academy of Sciences)

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Identification and characterization of the furfural and 5-(hydroxymethyl)furfural degradation pathways of Cupriavidus basilensis HMF14 [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

The toxic fermentation inhibitors in lignocellulosic hydrolysates pose significant problems for the production of second-generation biofuels and biochemicals. Among these... (Source: Proceedings of the National Academy of Sciences)

The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

To protect cells from oxidative DNA damage and mutagenesis, organisms possess multiple glycosylases to recognize the damaged bases and to... (Source: Proceedings of the National Academy of Sciences)

Allosteric modulation of Ras positions Q61 for a direct role in catalysis [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

Ras and its effector Raf are key mediators of the Ras/Raf/MEK/ERK signal transduction pathway. Mutants of residue Q61 impair the... (Source: Proceedings of the National Academy of Sciences)

Origins of catalysis by computationally designed retroaldolase enzymes [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

We have investigated recently reported computationally designed retroaldolase enzymes with the goal of understanding the extent and the origins of... (Source: Proceedings of the National Academy of Sciences)

A zinc-binding site by negative selection induces metallodrug susceptibility in an essential chaperonin [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

GroES is an indispensable chaperonin virtually found throughout all life forms. Consequently, mutations of this protein must be critically scrutinized... (Source: Proceedings of the National Academy of Sciences)

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Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

Measurements of nucleoside triphosphate levels in Saccharomyces cerevisiae reveal that the four rNTPs are in 36- to 190-fold molar excess... (Source: Proceedings of the National Academy of Sciences)

An unlocking/relocking barrier in conformational fluctuations of villin headpiece subdomain [Chemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

A reversible structural unlocking reaction, in which the close-packed van der Waals interactions break cooperatively, has been found for the... (Source: Proceedings of the National Academy of Sciences)

Large-scale conformational sampling of proteins using temperature-accelerated molecular dynamics [Biophysics_And_Computational_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

We show how to apply the method of temperature-accelerated molecular dynamics (TAMD) in collective variables [Maragliano L, Vanden-Eijnden E (2006)... (Source: Proceedings of the National Academy of Sciences)

4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement [Biophysics_And_Computational_Biology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:03 +0100

The essential double-ring eukaryotic chaperonin TRiC/CCT (TCP1-ring complex or chaperonin containing TCP1) assists the folding of ~5–10% of the cellular... (Source: Proceedings of the National Academy of Sciences)

Identifying the roles of race-based choice and chance in high school friendship network formation [Economic_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:02 +0100

Homophily, the tendency of people to associate with others similar to themselves, is observed in many social networks, ranging from... (Source: Proceedings of the National Academy of Sciences)

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Interaction of natural survival instincts and internalized social norms exploring the Titanic and Lusitania disasters [Economic_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:02 +0100

This study explores... (Source: Proceedings of the National Academy of Sciences)

The dimensionality of discourse [Psychological_And_Cognitive_Sciences-SS]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:02 +0100

The paragraph spaces of five text corpora, of different genres and intended audiences, in four different languages, all show the... (Source: Proceedings of the National Academy of Sciences)

Geometric cues for directing the differentiation of mesenchymal stem cells [Applied_Biological_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:02 +0100

Significant efforts have been directed to understanding the factors that influence the lineage commitment of stem cells. This paper demonstrates... (Source: Proceedings of the National Academy of Sciences)

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124 [Chemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:02 +0100

Firefly luciferase (FLuc), an ATP-dependent bioluminescent reporter enzyme, is broadly used in chemical biology and drug discovery assays. PTC124 (Ataluren;... (Source: Proceedings of the National Academy of Sciences)

In This Issue [This Week in PNAS]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

(Source: Proceedings of the National Academy of Sciences)

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Leveraging leptin for type I diabetes? [Commentaries]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

(Source: Proceedings of the National Academy of Sciences)

A strong role for nature in face recognition [Commentaries]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

(Source: Proceedings of the National Academy of Sciences)

New perspectives on anthropoid origins [Perspective]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

Adaptive shifts associated with human origins are brought to light as we examine the human fossil record and study our... (Source: Proceedings of the National Academy of Sciences)

Inaugural Article: Four generations of transition-state analogues for human purine nucleoside phosphorylase [Biochemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

Inhibition of human purine nucleoside phosphorylase (PNP) stops growth of activated T-cells and the formation of 6-oxypurine bases, making it... (Source: Proceedings of the National Academy of Sciences)

Feature Article: Leptin therapy in insulin-deficient type I diabetes [Medical_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

In nonobese diabetic mice with uncontrolled type 1 diabetes, leptin therapy alone or combined with low-dose insulin reverses the catabolic... (Source: Proceedings of the National Academy of Sciences)

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Discovering the flight autostabilizer of fruit flies by inducing aerial stumbles [Applied_Biological_Sciences]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

Just as the Wright brothers implemented controls to achieve stable airplane flight, flying insects have evolved behavioral strategies that ensure... (Source: Proceedings of the National Academy of Sciences)

Stimulated coherent anti-Stokes Raman spectroscopy (CARS) resonances originate from double-slit interference of two-photon Stokes pathways [Chemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

Coherent anti-Stokes Raman spectroscopy (CARS) uses vibrational resonances to study nuclear wavepacket motions and is widely used in cell imaging... (Source: Proceedings of the National Academy of Sciences)

An atomistic picture of the regeneration process in dye sensitized solar cells [Chemistry]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

A highly efficient mechanism for the regeneration of the cis-bis(isothiocyanato)bis(2,2'-bipyridyl-4,4'-dicarboxylato)-ruthenium(II) sensitizing dye (N3) by I- in acetonitrile has been identified... (Source: Proceedings of the National Academy of Sciences)

Magnetically driven three-dimensional manipulation and inductive heating of magnetic-dispersion containing metal alloys [Engineering]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

Fundamental to the development of three-dimensional microelectronic fabrication is a material that enables vertical geometries. Here we show low-melting-point metal... (Source: Proceedings of the National Academy of Sciences)

Kadison-Singer algebras, II: General case [Mathematics]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

A new class of operator algebras, Kadison–Singer (KS-) algebras, is introduced. These highly noncommutative, non self-adjoint algebras generalize triangular matrix... (Source: Proceedings of the National Academy of Sciences)

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Analytic index for a family of Dirac-Ramond operators [Mathematics]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

We derive a cohomological formula for the analytic index of a family of Dirac–Ramond operators and exhibit its modular properties. (Source: Proceedings of the National Academy of Sciences)

The imprint of China's first emperor on the distant realm of eastern Shandong [Anthropology]

Proceedings of the National Academy of Sciences — Tue, 16 Mar 2010 19:33:01 +0100

Imperial expansion is recurrent in human history. For early empires, such as in ancient China, this process generally is known... (Source: Proceedings of the National Academy of Sciences)

Final Day to Vote for Neuro Film Festival Videos

American Academy of Neurology — Tue, 16 Mar 2010 18:49:00 +0100

The entries for the 2010 Neuro Film Festival are in and public voting for "Fan Favorite" will continue through tomorrow. The Neuro Film Festival is a contest by the American Academy of Neurology Foundation to help raise awareness through video about brain disorders and the need to support research into preventions, treatments and cures. (Source: American Academy of Neurology)

EU-Canada cooperation programme in higher education, training and youth - Call for funding

Tue, 16 Mar 2010 17:08:30 +0100

Aims: 1. promote mutual understanding between the peoples of the European Union and Canada, including broader knowledge of their languages, cultures and institutions; 2. improve the quality of human resources in the European Union and Canada by facilitating the acquisition of skills required to meet the challenges of the global knowledge-based economy. Objectives: 1. support collaboration between higher education and/or training institutions with a view to promoting and developing joint study and/or training programmes and student/faculty mobility; and 2. improve the quality of transatlantic student mobility by promoting transparency, mutual recognition of qualifications and periods of study and training, and where appropriate, portability of credits. Eligible partners and partne...

Preliminary H1N1 Vaccine Surveillance Report Released

American Academy of Neurology — Tue, 16 Mar 2010 16:55:00 +0100

Throughout the 2009–2010 flu season, the AAN and CDC have conducted a collaborative surveillance effort to determine incidence of Guillain-Barré syndrome (GBS) following H1N1 vaccination nationwide. (Source: American Academy of Neurology)

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'Regrow limbs' claim is premature

NHS News Feed — Tue, 16 Mar 2010 16:23:00 +0100

Conclusion This study illustrates a role for the p21 gene in tissue regeneration in mice. Although many biological pathways share similarities between different species, there may also be distinct differences. Therefore findings on p21 in mice will need confirmation in human cells and tissues. Wound healing is a complex process, and even if p21 has a role in human healing a number of additional factors will also play a role. This study may lead to a better understanding of the human healing process. Realistically, it would be more likely to help in the development of treatments to aid wound healing rather than growing back whole limbs. However, even developing a treatment for wound healing based on this research would take a long time, and unfortunately such a treatment may eventually pro...

Editorial Board

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:18 +0100

(Source: Journal of the American Academy of Dermatology)

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:18 +0100

(Source: Journal of the American Academy of Dermatology)

Information for Readers

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:18 +0100

(Source: Journal of the American Academy of Dermatology)

Instructions for Category 1 CME Credit

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:18 +0100

(Source: Journal of the American Academy of Dermatology)

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Dermatology Calendar

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:18 +0100

(Source: Journal of the American Academy of Dermatology)

March iotaderma (#194)

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:17 +0100

(Source: Journal of the American Academy of Dermatology)

Iotaderma #195

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:15 +0100

(Source: Journal of the American Academy of Dermatology)

Narrowband ultraviolet B phototherapy influences serum folate levels in patients with vitiligo

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: We read with interest the article by Rose et al in the August 2009 issue of the Journal. Ultraviolet B light phototherapy (UVB) is generally considered the safest form of systemic psoriasis therapy in pregnancy. We commend the authors for creating a study to examine the photodegradation of serum folate after exposure to narrowband UVB (nbUVB), given that folate deficiency in the first trimester of pregnancy could predispose to the development of neural tube defects. (Source: Journal of the American Academy of Dermatology)

Myxoinflammatory fibroblastic sarcoma on the thigh

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: Myxoinflammatory fibroblastic sarcoma (MIFS) is a slow growing, low grade tumor reported as a soft tissue tumor affecting the distal extremities. It was first described in 1998 by Meis-Kindblom and Kindblom and Montgomery et al. Although it was described by different names—acral MIFS and inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg–like cells—it described the same entity of histologic features. The reported histologic similarities included numerous inflammatory cells (plasma cells, granulocytes, eosinophils, and lymphocytes), fibrosis, and scattered, large, bizarre tumor cells resembling Reed-Sternberg–like cells in an abundant myxoid extracellular matrix. Clinically, it is described in all age groups (4-91 yrs of age), occurs...

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Refractory oral ulcers with multiple immunoglobulin G/immunoglobulin A autoantibodies without skin lesions

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: Current molecular diagnostics have characterized many new autoimmune bullous diseases that traditional descriptive dermatology would not have been able to define. Herein we report a case of refractory oral ulcers with immunoblots that were confusing, causing difficulty in making a definitive diagnosis. (Source: Journal of the American Academy of Dermatology)

Acquired combined nutritional deficiency presenting as psoriasiform dermatitis

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: Nutritional deficiency, a prevalent problem worldwide, remains rare in developed countries. In the United States, acquired nutritional deficiencies have been reported in patients with anorexia nervosa, malabsorption syndromes, those on long-term parenteral nutrition, and patients with food allergies. Given the significant morbidity and sometimes mortality associated with certain nutritional deficiencies, their prompt recognition, diagnosis, and treatment by clinicians is of great importance. Many nutritional deficiencies have classic cutaneous presentations that are valuable clinical diagnostic tools. However, combined nutritional deficiencies often put forth a mixed clinical picture easily mistaken for another condition. There is a paucity of reports of cutaneous presentati...

Phenytoin-induced acute generalized exanthemous pustulosis

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: A 57-year-old African American male with a history of a seizure disorder caused by a traumatic head injury presented to the emergency department with a recent onset of multiple pustular lesions that started on his face and spread to his trunk and upper extremities. He had presented to the same emergency department 5 days earlier in status epilepticus. He was treated with 1 g phenytoin for the first time in addition to increased doses of his other medicines (lorazepam and levetiracetam). His seizure resolved and he was discharged 2 days later on increased doses of levetiracetam and valproic acid. (Source: Journal of the American Academy of Dermatology)

CD34+ connective tissue nevi: Are they unusual?

Journal of the American Academy of Dermatology — Tue, 16 Mar 2010 14:28:14 +0100

To the Editor: A 1-year-old white male with a 6-month history of “raised bumps” overlying the dorsal surface of his neck was brought to our dermatology clinic for evaluation. An agminated patch of white papules was identified on the suboccipital neck (). Nuchal ultrasound was unremarkable. A 3-mm punch biopsy demonstrated spindle cell proliferation within the papillary dermis, without significant atypia (, A). Vascularity was slightly increased. The overlying epidermis was unremarkable. Laboratory tests for Ulex europaeus, S-100, CD68, muscle-specific actin, and smooth muscle actin were negative. The spindle cells and visualized vascular structures stained strongly positive for CD34 (, B). After a thorough Web-based literature search, we were unable to find any reports of CD34+ stainin...