MedWorm: Graduation

Natural compound in bananas could hold key to stopping HIV

NaturalNews.com — Sun, 21 Mar 2010 07:00:00 +0100

(NaturalNews) University of Michigan (U-M) Medical School scientists have found a potent substance that could block the sexual transmission of HIV, the virus believed to cause AIDS. This HIV preventative isn't a potent new drug or chemical-laden vaccine. Instead, it's a natural substance derived from a popular, inexpensive fruit -- bananas.In their study, just published in the Journal of Biological Chemistry, the researchers noted that HIV/AIDS remains a world-wide epidemic. "HIV is still rampant in the U.S. and the explosion in poorer countries continues to be a bad problem because of tremendous human suffering and the cost of treating it," study senior author David Marvovitz, M.D., professor of internal medicine at the U-M Medical School, said in a statement to media.Bottom line: new way...

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A review of unintentional injuries in adolescents (*).

Annual Review of Public Health — Sat, 20 Mar 2010 18:44:14 +0100

Authors: Sleet DA, Ballesteros MF, Borse NN Unintentional injuries are the largest source of premature morbidity and mortality and the leading cause of death among adolescents 10-19 years of age. Fatal injury rates of males are twice those of females, and racial disparities in injury are pronounced. Transportation is the largest source of these injuries, principally as drivers and passengers, but also as cyclists and pedestrians. Other major causes involve drowning, poisonings, fires, sports and recreation, and work-related injuries. Implementing known and effective prevention strategies such as using seat belts and bicycle and motorcycle helmets, installing residential smoke alarms, reducing misuse of alcohol, strengthening graduated driver licensing laws, promoting policy change, usi...

Oh, The Drama! Med School Class Of 2010 To Learn Where They've "Matched" For Residency

Health News from Medical News Today — Fri, 19 Mar 2010 23:00:00 +0100

Hugs, high fives, cheers and a few tears will abound when the Johns Hopkins University School of Medicine's seniors find out which hospital residency programs they will enter after graduation this spring. The fourth-year students will gather for this annual, invitation-only celebration on the medical campus, where they'll open official letters in the presence of classmates, professors and loved ones. The event for the 107th graduating class is slated to take place on Thursday, March 18, from 10:30 a.m. to 12 p.m... (Source: Health News from Medical News Today)

Oh, The Drama! Med School Class Of 2010 To Learn Where They've "Matched" For Residency

Medical Students News From Medical News Today — Fri, 19 Mar 2010 23:00:00 +0100

Residency Match Results Not Encouraging For Adults Needing Primary Care

Health News from Medical News Today — Fri, 19 Mar 2010 16:00:00 +0100

The number of U.S. medical students choosing internal medicine residencies inched higher from 2009 but not enough to significantly impact the shortage of primary care physicians. According to the 2010 National Resident Matching Program report, 2,722 U.S. seniors at medical schools enrolled in an internal medicine residency program, a 3.4 percent increase from 2,632 in 2009. The internal medicine enrollment numbers are similar to 2008 (2,660), 2007 (2,680), and 2006 (2,668). In comparison, 3,884 U.S. medical school graduates chose internal medicine residency programs in 1985... (Source: Health News from Medical News Today)

Mentoring in otolaryngology training programs

Otolaryngology - Head and Neck Surgery — Fri, 19 Mar 2010 15:22:34 +0100

Conclusion: Residents perceive mentoring as important, and formal mentoring programs should be incorporated into otolaryngology training programs. (Source: Otolaryngology - Head and Neck Surgery)

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Celebrate science every week

Guardian Unlimited Science — Fri, 19 Mar 2010 14:30:00 +0100

This article was commissioned after the author suggested it in a You tell us threadMathematicsPhysicsChemistryBiologyScienceClaire McWhirterguardian.co.uk © Guardian News & Media Limited 2010 | Use of this content is subject to our Terms & Conditions | More Feeds (Source: Guardian Unlimited Science)

AAMC Pleased More Medical School Graduates Are Matching To Primary Care Residencies

Health News from Medical News Today — Fri, 19 Mar 2010 11:00:00 +0100

AAMC (Association of American Medical Colleges) President and CEO Darrell G. Kirch, M.D., issued the following statement on Match Day results released this afternoon by the National Resident Matching Program (NRMP) for U.S. medical school graduates and the primary care specialties: "The AAMC is extremely encouraged that more graduating U.S. medical students this year chose primary care for their residency training... (Source: Health News from Medical News Today)

AAMC Pleased More Medical School Graduates Are Matching To Primary Care Residencies

Medical Students News From Medical News Today — Fri, 19 Mar 2010 11:00:00 +0100

AAMC (Association of American Medical Colleges) President and CEO Darrell G. Kirch, M.D., issued the following statement on Match Day results released this afternoon by the National Resident Matching Program (NRMP) for U.S. medical school graduates and the primary care specialties: "The AAMC is extremely encouraged that more graduating U.S... (Source: Medical Students News From Medical News Today)

Clinical significance of the ratio between the alpha 2 plasmin inhibitor–plasmin complex and the thrombin–antithrombin complex in advanced non-small cell lung cancer

Medical Oncology — Fri, 19 Mar 2010 06:52:33 +0100

In this study, a low PIC/TAT ratio and poor PS were significant independent negative prognostic factors for survival in patients with advanced NSCLC. The PIC/TAT ratio may become a surrogate marker for treatment with anticoagulants in the future. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9454-yAuthors Katsuhiro Masago, Kyoto University Department of Respiratory Medicine, Graduate School of Medicine 54 Syogoin-Kawaracho, Sakyo-Ku Kyoto 606-8507 JapanShiro Fujita, Institute of Biomedical Research and Innovation Division of Integrated Oncology Kobe JapanTadashi Mio, Kyoto University Department of Respiratory Medicine, Graduate School of Medicine 54 Syogoin-Kawaracho, Sakyo-Ku Kyoto 606-8507 JapanYosuke Togashi, Kyoto University Department of Respirator...

Vulnerable Sites and Changes in Mucin in the Rat Small Intestine After Non-steroidal Anti-inflammatory Drugs Administration

Digestive Diseases and Sciences — Fri, 19 Mar 2010 06:51:27 +0100

Conclusions Vascularly compromised sites along the jejunal mesenteric margin are vulnerable to NSAIDs-induced damage and show increased numbers of enterobacteria in the NSAIDs-treated mucosa. Increased sialomucin content in the mucus around the lesions may play an important role in the healing of NSAIDs-induced intestinal lesions. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1185-6Authors Tomohisa Iwai, Kitasato University School of Medicine Department of Gastroenterology Sagamihara JapanTakafumi Ichikawa, Kitasato University Graduate School of Medical Sciences Department of Regulation Biochemistry 1-15-1, Kitasato Sagamihara, Kanagawa 228-8555 JapanMitsuhiro Kida, Kitasato University School of Medicine Department of Gastroenterology S...

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Codon usage bias and recombination events for neuraminidase and hemagglutinin genes in Chinese isolates of influenza A virus subtype H9N2

Archives of Virology — Fri, 19 Mar 2010 06:49:30 +0100

Abstract The representative complete neuraminidase sequences (NA) of 138 Chinese isolates and hemagglutinin sequences (HA) of 128 Chinese isolates of influenza A virus subtype H9N2 were analyzed to reveal codon usage bias and recombination events. A plot of the effective number of codons (ENC) against G + C context at the third position of the codons (ENC-plot) and correlation analysis demonstrated that mutational pressure is the main factor determining the codon usage bias in the H9N2 subtype. The high ENC values (51.31 for NA and 48.83 for HA) indicated that the codon usage bias in Chinese H9N2 isolates was very low. Plots of correspondence analysis and an ENC plot indicated that the HA and NA genes had different codon usage bias. Recombination analysis reveale...

GW Ph.D. candidate and UCL grad student discover new species of raptor dinosaur

EurekAlert! - Biology — Fri, 19 Mar 2010 04:00:00 +0100

(George Washington University) A new species of raptor dinosaur being named Linheraptor exquisitus has been discovered by George Washington University doctoral candidate Jonah Choiniere and Michael D. Pittman, a graduate student at University College London. (Source: EurekAlert! - Biology)

Devastated over being dumped? Control what you can

Psychology Today Relationships Center — Fri, 19 Mar 2010 00:28:09 +0100

QUESTIONDear Irene,A college friend named Leah recently dumped me. I graduated but she's still in her final year. We live three-hours apart but we've met up about a dozen times since graduation in May. The last few times, she was very distant and seemed to actively avoid talking or being with me (we were always in the company of other people).In October, after one such occasion, I texted saying I felt hurt and couldn't understand why she was cold and distant. She replied saying I was selfish, and didn't understand how tired she was after work and so forth. I felt guilty for saying anything at all and didn't initiate any contact for about three weeks. I sent her texts and called numerous times in November but she never responded. Just before Christmas, she answered one of my calls and apolo...

[Perspectives] Lifeline: Sunetra Gupta

LANCET — Fri, 19 Mar 2010 00:00:00 +0100

Sunetra Gupta was born in Calcutta in 1965, graduated in 1987 from Princeton University, received her PhD from the University of London in 1992, and is now Professor of Theoretical Epidemiology at the University of Oxford, UK. She lives in Oxford with her husband and two daughters, and is also the author of five novels. (Source: LANCET)

Specialist English as a foreign language for European public health: evaluation of competencies and needs among Polish and Lithuanian students.

Medicina (Kaunas) — Thu, 18 Mar 2010 21:02:03 +0100

CONCLUSIONS. Similar levels of English language in all five areas of language skills were established in Polish and Lithuanian university students. Respondents gave more priorities to less formal and practice-based interactive English teaching methods (going abroad, contacts with native speakers) in comparison with theory-oriented or classroom-based methods of learning (self-studying, Internet courses). Survey showed a growing interest of students in improving English language in the future in Poland and Lithuania. PMID: 20234164 [PubMed - as supplied by publisher] (Source: Medicina (Kaunas))

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Fundus autofluorescence and spectral-domain optical coherence tomography findings of leopard spots in nanophthalmic uveal effusion syndrome

Graefe's Archive for Clinical and Experimental Ophthalmology — Thu, 18 Mar 2010 19:27:46 +0100

Conclusions Simultaneous imaging of the fundus with multiple modalities including OCT, FAF, FA, and ICGA indicates that leopard spots in the fundus of uveal effusion syndrome may show hyperautofluorescence and correspond to focal thickening of the RPE layer by SD-OCT. This imaging method may help elucidate the pathology of various fundus lesions in vivo. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00417-010-1352-7Authors Tetsuhiko Okuda, Kanazawa University Graduate School of Medical Science Department of Ophthalmology 13-1 Takara-machi Kanazawa Ishikawa Prefecture 920-8641 JapanTomomi Higashide, Kanazawa University Graduate School of Medical Science Department of Ophthalmology 13-1 Takara-machi Kanazawa Ishikawa Prefecture 920-8641 JapanYuka Wakaba...

Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica

Graefe's Archive for Clinical and Experimental Ophthalmology — Thu, 18 Mar 2010 19:27:43 +0100

Conclusions The overall thinner RNFL in eyes with NMO than in eyes with MS indicates a greater loss of optic nerve axons in eyes with NMO. An early intervention with HIMP and preventing recurrences in NMO are critical for minimizing the axonal loss. Our findings indicate that OCT is an important method of evaluating loss of optic nerve axons in eyes with NMO and MS. Content Type Journal ArticleCategory Neuro-ophthalmologyDOI 10.1007/s00417-010-1344-7Authors Masahiko Nakamura, Tohoku University Graduate School of Medicine Department of Ophthalmology 1-1 Seiryo-machi, Aoba-ku Sendai, Miyagi 980-8574 JapanToru Nakazawa, Tohoku University Graduate School of Medicine Department of Ophthalmology 1-1 Seiryo-machi, Aoba-ku Sendai, Miyagi 980-8574 JapanHiroshi Doi, Tohoku Un...

Style Profile: A Visual, Verbal, & Behavioral Evolution to Success

Psychology Today Work Center — Thu, 18 Mar 2010 17:14:50 +0100

Each month The Image Professor Blog will publicly showcase the style evolution of a professional "mover & shaker" excelling in their specific industry. We'll discover how they've used (1) clothing, (2) grooming, and (3) behavior to achieve visual and verbal success. Read how powerful and stylish leaders are making their contribution to our communities and world. Alert: Successful people reveal their secrets; this is a worthwhile read.  Our first Style Profile is Amy Storer-Scalia, Founder & Editor of an award-winning online magazine offering health, beauty, fashion, social, and career information to women seeking inspiration and transformation. Discover how Amy morphed fr...

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

Hepatology International — Thu, 18 Mar 2010 15:40:03 +0100

Abstract Introduction The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on the management of hepatocellular carcinoma (HCC) in December 2008 to develop consensus recommendations. Methods The working party consisted of expert hepatologist, hepatobiliary surgeon, radiologist, and oncologist from Asian-Pacific region, who were requested to make drafts prior to the consensus meeting held at Bali, Indonesia on 4 December 2008. The quality of existing evidence and strength of recommendations were ranked from 1 (highest) to 5 (lowest) and from A (strongest) to D (weakest), respectively, according to the Oxford system of evidence-based approach for developing the consensus statements. Results &...

Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I)

Journal of Natural Medicines — Thu, 18 Mar 2010 15:39:03 +0100

Abstract To investigate the pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe, the pharmacokinetic parameters were determined by using 14C-[6]-shogaol (labeled compound) and [6]-shogaol (non-labeled compound). When the labeled compound was orally administered to rats, the maximum plasma concentration (C max) and the area under the curve (AUC) of plasma radioactivity concentration increased in a dose-dependent manner. When the labeled compound was orally administered at a dose of 10 mg/kg, 20.0 ± 1.8% of the radioactivity administered was excreted into urine, 64.0 ± 12.9% into feces, and 0.2 ± 0.1% into breath. Thus, more of the radioactivity was excreted into feces than into urine, and almost no radioac...

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Histological liver injury and surgical outcome after FOLFOX followed by a hepatectomy for colorectal liver metastases in Japanese patients

International Journal of Clinical Oncology — Thu, 18 Mar 2010 15:36:10 +0100

Conclusions Although preoperative FOLFOX administration in patients with colorectal liver metastases caused macroscopic blue liver, microscopic sinusoidal dilatationin the liver parenchyma, and a significant decrease in liver function, there was no increase in the morbidity and mortality rates, in comparison to findings in patients without preoperative chemotherapy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0046-9Authors Hiroyuki Komori, Kumamoto University Department of Gastroenterological Surgery, Graduate School of Medical Sciences 1-1-1 Honjyo Kumamoto 860-8556 JapanToru Beppu, Kumamoto University Department of Gastroenterological Surgery, Graduate School of Medical Sciences 1-1-1 Honjyo Kumamoto 860-8556 JapanYoshifumi Baba, Ku...

Nicotine provokes impulsive-like action by stimulating α4β2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex

Psychopharmacology — Thu, 18 Mar 2010 15:34:51 +0100

Conclusion The present results suggest a critical role for α4β2 nAChRs in the IL in mediating the effects of nicotine on impulsive-like action in the 3-CSRTT. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-010-1804-0Authors Iku Tsutsui-Kimura, Hokkaido University Department of Neuropharmacology, Graduate School of Medicine N15 W7 Kita-ku Sapporo 060-8638 JapanYu Ohmura, Hokkaido University Department of Neuropharmacology, Graduate School of Medicine N15 W7 Kita-ku Sapporo 060-8638 JapanTakeshi Izumi, Hokkaido University Department of Neuropharmacology, Graduate School of Medicine N15 W7 Kita-ku Sapporo 060-8638 JapanTaku Yamaguchi, Hokkaido University Department of Neuropharmacology, Graduate School of Medicine N15 W7 Kita-ku Sapporo ...

FK506 inhibition of gliostatin/thymidine phosphorylase production induced by tumor necrosis factor-α in rheumatoid fibroblast-like synoviocytes

Rheumatology International — Thu, 18 Mar 2010 15:24:34 +0100

Abstract Gliostatin/thymidine phosphorylase (GLS/TP) is known to have angiogenic and arthritogenic activities. The purpose of this study was to determine the inhibitory effects of FK506 (tacrolimus) on GLS production in rheumatoid arthritis (RA). We investigated the modulation of serum GLS by FK506 therapy and the effect of FK506 on the production of GLS in fibroblast-like synoviocytes (FLSs). Serum samples were collected from 11 RA patients with active disease at baseline and after 12 weeks of FK506 treatment. Serum concentrations of GLS and matrix metalloproteinase (MMP)-3 were measured by ELISA and found to be down-regulated in responders evaluated with a disease activity score. Patient FLSs were cultured and stimulated by tumor necrosis factor (TNF)-α with or wit...

Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment: a case report

Esophagus — Thu, 18 Mar 2010 15:10:41 +0100

We report a case of esophagectomy after a primary esophageal gastrointestinal stromal tumor (GIST) was preoperatively treated with imatinib mesylate. A 71-year-old woman was diagnosed with an esophageal submucosal tumor by upper gastrointestinal endoscopy at her health checkup. The tumor was located at the lower thoracic esophagus immediately above the esophagogastric junction and measured 4.5 cm in size. It was diagnosed as GIST of the esophagus for reasons of its high susceptibility to imatinib mesylate. Preoperative treatment with imatinib was performed in an attempt to preserve the esophagus. Although the tumor size was decreased by 36% after the 6-month treatment, transhiatal esophagectomy was required for complete resection, and esophageal preservation could not be accomplished...

A case of metastatic esophageal tumor from breast cancer

Esophagus — Thu, 18 Mar 2010 15:10:35 +0100

Abstract A 58-year-old woman was admitted to our hospital with the complaint of dysphagia that had developed 37 months after initiation of treatment for breast cancer. Endoscopy revealed severe stenosis 32 cm from the incisors through which the endoscope could not pass. No mucosal irregularities were observed, and biopsies of the stenotic lesion were negative for malignancy. Computed tomography showed wall thickening of the midthoracic esophagus and left pleural effusion, which had increased metabolic activity as detected by 18F-fluorodeoxyglucose positron emission tomography. Cytological examination of the pleural effusion showed adenocarcinoma compatible with metastasis from a prior lobular carcinoma of the breast. Vinorelbine effectively relieved her symptoms, and the di...

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Erratum to: Spatial resolution of FineCube, a newly developed cone-beam computed tomography system

Oral Radiology — Thu, 18 Mar 2010 14:15:27 +0100

Content Type Journal ArticleCategory ErratumDOI 10.1007/s11282-010-0033-xAuthors Hiroshi Watanabe, Tokyo Medical and Dental University Oral and Maxillofacial Radiology, Division of Oral Restitution, Graduate School 5-45 Yushima 1-chome, Bunkyo-ku Tokyo 1138549 JapanT. Wagatsuma, The Yoshida Dental Mfg. Co., Ltd Diagnostic Imaging Division Tokyo JapanY. Nomura, Tokyo Medical and Dental University Oral and Maxillofacial Radiology, Division of Oral Restitution, Graduate School 5-45 Yushima 1-chome, Bunkyo-ku Tokyo 1138549 JapanE. Honda, The University of Tokushima Graduate School Oral and Maxillofacial Radiology, Division of Oral Health Sciences Tokushima JapanT. Kurabayashi, Tokyo Medical and Dental University Oral and Maxillofacial Radiology, Division of Oral Restitution, Graduate Schoo...

Mechanical and clinical performance of pulse-inversion tissue harmonic imaging in the superficial region

Journal of Medical Ultrasonics — Thu, 18 Mar 2010 14:15:24 +0100

Conclusion This study suggests that PI-THI might be mechanically and clinically useful in the superficial region. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10396-010-0258-7Authors Chieko Sugawara, The University of Tokushima Graduate School Department of Oral and Maxillofacial Radiology, Institute of Health Biosciences 3-18-15 Kuramoto-cho Tokushima Tokushima 770-8504 JapanAkira Takahashi, Tokushima University Hospital 3-18-15 Kuramoto-cho Tokushima Tokushima 770-8504 Japan Journal Journal of Medical UltrasonicsOnline ISSN 1613-2254Print ISSN 1346-4523 (Source: Journal of Medical Ultrasonics)

Neuropathic pain and neuron–glia interactions in the spinal cord

Journal of Anesthesia — Thu, 18 Mar 2010 14:14:18 +0100

Content Type Journal ArticleCategory JA SymposiumDOI 10.1007/s00540-010-0918-1Authors Tatsuro Kohno, Niigata University Graduate School of Medical and Dental Sciences Division of Anesthesiology 1-757 Asahimachi Niigata 951-8510 Japan Journal Journal of AnesthesiaOnline ISSN 1438-8359Print ISSN 0913-8668 (Source: Journal of Anesthesia)

Phantom limb pain in the primary motor cortex: topical review

Journal of Anesthesia — Thu, 18 Mar 2010 14:14:16 +0100

Content Type Journal ArticleCategory JA SymposiumDOI 10.1007/s00540-010-0921-6Authors Masahiko Sumitani, University of Tokyo Hospital Department of Anesthesiology and Pain Relief Center 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanSatoru Miyauchi, National Institute of Information and Communications Technology Kobe Advanced ICT Research Center Kobe JapanArito Yozu, The University of Tokyo Department of Rehabilitation Medicine, Graduate School of Medicine Tokyo JapanYuko Otake, The University of Tokyo Department of Rehabilitation Medicine, Graduate School of Medicine Tokyo JapanYouichi Saitoh, Osaka University Department of Neurosurgery, Graduate School of Medicine Osaka JapanYoshitsugu Yamada, University of Tokyo Hospital Department of Anesthesiology and Pain Relief Center 7-3-1 Hongo, B...

Diaphragmatic Hernia After Radiofrequency Ablation for Hepatocellular Carcinoma

CardioVascular and Interventional Radiology — Thu, 18 Mar 2010 14:13:20 +0100

We describe a 71-year-old woman with a hepatocellular carcinoma who underwent percutaneous radiofrequency ablation (RF) with a single internally cooled electrode under computed tomography (CT) fluoroscopic guidance. Nine months after the procedure, CT images showed herniation of the large intestine into the right pleural cavity. To our knowledge this complication of RF performed with a single internally cooled electrode under CT guidance has not been previously reported. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00270-010-9832-zAuthors Takuji Yamagami, Kyoto Prefectural University of Medicine Department of Radiology, Graduate School of Medical Science 465 Kajii-chou, Kawaramachi-Hirokoji, Kamigyo-Ku Kyoto 602-8566 JapanRika Yoshimatsu, Kyoto Prefectural Univers...

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Health Advocacy Graduate Students To Assist Residents Of 'Toxic Town' During Spring Break, March 19 - 27

Health News from Medical News Today — Thu, 18 Mar 2010 10:00:00 +0100

Eight Sarah Lawrence College graduate students are assisting the residents of Mossville, LA, suffering illnesses in highly disproportionate numbers to the general population from the effects of air and ground water pollution. The students, who will travel to Mossville for the third time on March 19 during their spring break, will provide the advocacy group, Mossville Environmental Action Now (M.E.A.N... (Source: Health News from Medical News Today)

Health Advocacy Graduate Students To Assist Residents Of 'Toxic Town' During Spring Break, March 19 - 27

Water Quality / Air Quality News From Medical News Today — Thu, 18 Mar 2010 10:00:00 +0100

Family Medicine Gains 101 U.S. Medical School Graduates in 2010 Residency Match

AAFP News Releases and Statements — Thu, 18 Mar 2010 05:00:00 +0100

Family medicine residency training programs this year attracted 101 more U.S. medical school graduates to the specialty than in 2009, according to the National Residency Match Program results announced today. Known as the Match, the results show family medicine drew 1,184 U.S. graduates. (Source: AAFP News Releases and Statements)

Other Health Professions Need Support As Well - Pharmaceutical Society Of Australia

Health News from Medical News Today — Thu, 18 Mar 2010 00:00:00 +0100

The Government's announcement of a substantial boost in GP training places, specialist training places and pre-vocational general practice placements for medical graduates is a welcome development, but other health professions need similar support, the Pharmaceutical Society of Australia says. National President of the PSA, Warwick Plunkett, said that in moving to the Government's preferred primary health-care team model, it was important the difficulties facing the other professions in the primary health-care team were also recognised and acted upon... (Source: Health News from Medical News Today)

Other Health Professions Need Support As Well - Pharmaceutical Society Of Australia

Medical Students News From Medical News Today — Thu, 18 Mar 2010 00:00:00 +0100

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Borchard Fellowship in Law & Aging

ScanGrants feed — Thu, 18 Mar 2010 00:00:00 +0100

Borchard Fellowship in Law & Aging The Borchard Fellowship in Law & Aging affords one year for two law school graduates interested in, and perhaps already in the early stages of pursuing, an academic and/or professional career in law and aging, the opportunity to pursue their research and professional interests.During the Fellowship period, the Center’s Executive Director and Assistant Director stand ready to assist each Fellow with the further development of his/her knowledge, skills, and contacts. A legal services or other non-profit organization involved in law and aging must supervise a Fellow’s activities and projects. In addition to the Fellow's planned activities and project (unless the Fellow's project includes the provision of legal services), the Fellow must a...

Annette U. Rickel Dissertation Award

ScanGrants feed — Thu, 18 Mar 2010 00:00:00 +0100

This award supports dissertation research on public policy, which has the potential to improve services for children and families facing psychosocial issues.Deadline: November 1, 2010Sponsor: American Psychological Foundation DescriptionExamples of eligible topics include but are not limited to issues with at-risk populations, prevention of child abuse, services for youth in the criminal justice system, effectiveness of school programs for children with psychological issues, using psychology in public policy to improve math and science education, and promoting healthy parenting.The scholarship amount is $1,000. Applicants must be graduate students in psychology enrolled full time and in good standing in a graduate program in psychology at a regionally ‐ accredited university or college ...

HHMI’s Gilliam Fellowships Aim to Increase Diversity in Sciences

NIGMS - Results — Wed, 17 Mar 2010 16:28:29 +0100

Former IMSD scholar Lisandro Maya-Ramos was named a 2010 Gilliam fellow by the Howard Hughes Medical Institute. The fellowship provides graduate school support annually for up to 5 years to help move recipients toward careers in science research and teaching. (Source: NIGMS - Results)

Graduating doctor numbers decline

IOL: Health — Wed, 17 Mar 2010 16:19:05 +0100

The Democratic Alliance on Wednesday lamented the decline in the number of doctors graduating in South Africa from 1394 in 2004 to 1306 in 2009. (Source: IOL: Health)

Evaluation of the risk of radiation exposure from new 18FDG PET/CT plans versus conventional X-ray plans in patients with pediatric cancers

Annals of Nuclear Medicine — Wed, 17 Mar 2010 15:52:02 +0100

Conclusions New 18FDG PET/CT plans may relieve the patient’s physical burden and contribute to improvement of the patient’s QOL. These plans may also reduce medical costs because the number of examinations to be performed is reduced. Although deterministic effects are not observed in the CI plan, careful attention should be paid to other potential effects. Because the effective dose resulting from this plan is over 100 mSv, at which stochastic effects are known to occur, radiation-induced cancers may be expected. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12149-010-0342-5Authors Takeshi Murano, National Cancer Center Division of Cancer Screening, Research Center for Cancer Prevention and Screening 5-1-1 Tsukiji, Chuo-ku Tokyo 104-00...

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UH inks Memorandum of Understanding with prestigious engineering institute in India

EurekAlert! - Social and Behavioral Science — Wed, 17 Mar 2010 04:00:00 +0100

(University of Houston) The University of Houston and the Institute of Technology, Banaras Hindu University, Varanasi, India, have signed a Memorandum of Understanding that will allow the two universities to explore new methods of cooperation in instruction and academic exchange. This new working relationship will include joint education programs at the graduate level, exchange visits of scholars and faculty collaboration in research and technology. (Source: EurekAlert! - Social and Behavioral Science)

A client-centred, occupation-based occupational therapy programme for adults with psychiatric diagnoses

Occupational Therapy International — Wed, 17 Mar 2010 00:00:00 +0100

The purpose of this study was to assess the effectiveness of a client-centred, occupation-based occupational therapy programme for individuals with psychiatric diagnoses. The study took place in a college campus.A pre-test/post-test design was used. There were 38 participants which included college students and community members who desired to attend college, work and/or address life skill goals. The Canadian Occupational Performance Measure (COPM) was used as a pre- and post-test measure. Goals were based on problems identified in the COPM, reflected academic, vocational, life skill, and leisure goals, and were systematically addressed weekly through activities developed by the participant and a graduate occupational therapy student who acted as a mentor. The Participant Overall Satisfact...

A study investigating obstetricians' and gynaecologists' management of women requesting an intrauterine device

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Wed, 17 Mar 2010 00:00:00 +0100

Background: Intrauterine methods including the copper intrauterine device (Cu-IUD) and the levonorgestrel intrauterine system (LNG-IUS) provide highly effective long-term reversible contraception. The reasons for relative low use of these methods in Australia compared to many European countries are not clear, but may in part relate to provider reluctance because of outdated knowledge about their safety and efficacy.Aims: The aim of this study was to survey Australian Fellows of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists about their knowledge of the risks, benefits and mechanisms of action of intrauterine methods.Methods: In 2008, we undertook a cross-sectional survey of all Australian Fellows not registered as a subspecialist. The survey was mailed to ...

Merlin Olsen Passes from Mesothelioma

About.com Lung Cancer — Wed, 17 Mar 2010 00:00:00 +0100

Football legend Merlin Olsen passed away last week from mesothelioma. Of course, like most people, I have been remembering this member of the "Fearsome Foursome." But today my thoughts turned to his individual nickname. The "Gentle Giant." Not in the context of football from which the title was coined, but in relation to the disease that brought him down. This man - who still holds the Ram's all-time team record for number of tackles and graduated summa cum laude from Utah State University - was knocked down by something as small and unthinking as asbestos fibers. We should stand up and take notice. I think that's what Olsen would want us to do. Having filed lawsuits against NBC, NBC Universal, and 20th Century Fox before his death, he claimed that he was exposed to this cancer-caus...

AIBS Names 2010 Emerging Public Policy Leaders

Public Policy Reports — Tue, 16 Mar 2010 17:42:25 +0100

The American Institute of Biological Sciences (AIBS) has selected Meredith Niles, a graduate student at the University of California, Davis, Ryan Richards, a graduate student at the University of Maryland, College Park, and Leslie Smith, a graduate student at the University of Rhode Island, to receive the 2010 AIBS Emerging Public Policy Leadership Award (EPPLA). “AIBS is committed to fostering a productive dialogue between policymakers and scientists,” said AIBS Executive Director Dr. Richard O’Grady. “We applaud Meredith Niles, Ryan Richards, and Leslie Smith for exemplifying this commitment through their work.” Since 2003, AIBS has recognized the achievements of biology graduate students who have demonstrated an interest and aptitude for contributing to...

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Back To School: Education Policy Discussions Start

Public Policy Reports — Tue, 16 Mar 2010 17:42:25 +0100

The Obama Administration has released its plans for reauthorization of the Elementary and Secondary Education Act (more recently referred to as No Child Left Behind). According to Department of Education documents, the Administration’s plan will “help states raise expectations of students and reward schools for producing dramatic gains in student achievement. The blueprint provides incentives for states to adopt academic standards that prepare students to succeed in college and the workplace and create accountability systems that measure student growth toward meeting the goal that all children graduate and succeed in college.” Additionally, on 10 March 2010, the influential National Governors Association Center for Best Practices (NGA) and the Council of Chief State Sch...

In the AIBS Webstore

Public Policy Reports — Tue, 16 Mar 2010 17:42:25 +0100

“COMMUNICATING SCIENCE: A PRIMER FOR WORKING WITH THE MEDIA” Evolution, climate change, stem cell research — Scientists are frequently called upon to provide expert information on hot button issues that pervade the daily news headlines, yet most find themselves woefully unprepared for the bright lights of the television studio or leading questions from a newspaper journalist. A new publication from AIBS, “Communicating Science: A Primer for Working with the Media,” by Holly Menninger and Robert Gropp in the Public Policy Office, will prepare scientists for successful and effective media interviews. Recognizing that many scientists are reluctant to engage in media outreach, “Communicating Science” outlines compelling reasons for scientists to inte...

The 21st century PhD: Key issues from recruitment to completion

MEDEV Events — Tue, 16 Mar 2010 17:08:29 +0100

Discussion group. This Residential Workshop is intended for Graduate Deans, Research Supervisors, Research Administrators, Post-Docs and all those involved in the management of PGR student programmes. The cost of the Residential is £380 for UKCGE Members and £420 for non-members. This price includes overnight accommodation, all meals from dinner on 24th March to lunch on 25th March and other refreshments served during the workshop. (Source: MEDEV Events)

Graduate Psychology Education Program

Grants.gov — Tue, 16 Mar 2010 16:15:32 +0100

Funding Opportunity Number: HRSA-10-069 Opportunity Category: DiscretionaryFunding Instrument Type: GrantCategory of Funding Activity: HealthCFDA Number: 93.191Eligible Applicants Others (see text field entitled "Additional Information on Eligibility" for clarification)Agency Name HHS-HRSA (Source: Grants.gov)

Suppressive effects of liquid crystal compounds on the growth of the A549 human lung cancer cell line

Investigational New Drugs — Tue, 16 Mar 2010 14:49:52 +0100

Summary The aim of this study was to evaluate the biological activity and pharmacological activity of several amphiphilic liquid-crystalline compounds (LCs), i.e. phenylpyrimidine derivatives possessing D-glucamine and cyanobiphenyl derivatives with a terminal hydroxyl unit, to explore novel anti-cancer functions of the LCs. The anti-cancer properties of the LCs were investigated in A549 human lung cancer cells by assessing cell growth, cell cycle distribution, and cell signaling pathways using a flow cytometer and a Western blot analysis. In addition, the effect of LCs on the growth of WI-38 normal fibroblasts was examined. Consequently, the phenylpyrimidine derivatives and cyanobiphenyl derivatives showed cytostatic effects, causing the suppression of cell growth through ...

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MacGuffin Jobs

Psychology Today Work Center — Tue, 16 Mar 2010 14:32:09 +0100

It's South by Southwest time here in Austin, and I'm always inspired to write a post related to movies, metaphors, and careers. (Here's my post from last year.)A constant question from reporters these days is whether I'm seeing any change in the job market-- is anything opening up? And I talk about the increasing number of internships, part-time opportunities and entry-level positions I've noticed lately. Yes, they'll say, but are any real jobs opening up? Because the jobs I'm describing aren't perfect by any means: they might pay less than what someone was earning before, they might not be in the exact field they're seeking, and they might not even be full-time. I know they're not perfect-- but they just might be a MacGuffin.Alfred Hitchcock coined the term MacGuffin (also spelled "McGuff...

Extra Doctor Training Places "very Welcome"â�¦ Now It's Time To Back Them Up With A Rural Rescue Package, Australia

Health News from Medical News Today — Tue, 16 Mar 2010 14:00:00 +0100

The Rural Doctors Association of Australia (RDAA) has strongly welcomed today's announcement by the Federal Government that it will substantially increase GP training places, specialist training places and prevocational general practice placements for medical graduates. The Association has urged, however, that the Government must also introduce a much-needed Rural Rescue Package if there is to be any hope of enticing more young doctors to rural and remote practice... (Source: Health News from Medical News Today)

Extra Doctor Training Places "very Welcome" ... Now It's Time To Back Them Up With A Rural Rescue Package, Australia

Health News from Medical News Today — Tue, 16 Mar 2010 14:00:00 +0100

Extra Doctor Training Places "very Welcome" ... Now It's Time To Back Them Up With A Rural Rescue Package, Australia

Medical Students News From Medical News Today — Tue, 16 Mar 2010 14:00:00 +0100

AOA Presents Visiting Professorship Keynote 3/19

What's New on JEFFLINE — Tue, 16 Mar 2010 13:46:38 +0100

Join the Alpha Omega Alpha Medical Honor Society in welcoming Thomas Nasca, MD, MACP, back to campus to deliver the keynote address for the annual Visiting Professorship program. Dr. Nasca is a former Dean of the Jefferson Medical School and current Executive Director and CEO of the ACGME. “Graduate Medical Education: Lessons Learned for American in the Pilot Project for ACGME International Accreditation in Singapore” 3:00 p.m. Friday, March 19, 2010 Connelly Auditorium All Jeffersonians are welcome! View the event flyer. (Source: What's New on JEFFLINE)

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Slate Looks At 'Contraceptive Pioneers' And New Contraceptives In Development

Women's Health / OBGYN News From Medical News Today — Tue, 16 Mar 2010 12:00:00 +0100

After struggling for decades "to win support from the scientific community," contraceptive researchers have "re-established themselves as dedicated to a deserving craft with impressive developments that redefine conventional birth control," according to a Slate opinion piece by Jennifer Austin, a medical school graduate who is beginning an obstetrics and gynecology residency this summer... (Source: Women's Health / OBGYN News From Medical News Today)

Slate Looks At 'Contraceptive Pioneers' And New Contraceptives In Development

Health News from Medical News Today — Tue, 16 Mar 2010 12:00:00 +0100

Course on global health diplomacy

WHO Maternal, Newborn and Child Health — Tue, 16 Mar 2010 08:55:00 +0100

Graduate Institute of International and Development Studies (IHEID) (2010) (Source: WHO Maternal, Newborn and Child Health)

Oral health care reduces the risk of postoperative surgical site infection in inpatients with oral squamous cell carcinoma

Supportive Care in Cancer — Tue, 16 Mar 2010 08:49:37 +0100

Conclusion Oral health care may reduce the risk of postoperative WI in patients with OSCC. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00520-010-0853-6Authors Jun Sato, Hokkaido University, Graduate School of Dental Medicine Oral Diagnosis and Medicine, Department of Oral Pathobiological Science North 13, West 7, Kita-ku Sapporo 060-8586 JapanJun Goto, Hokkaido University, Graduate School of Dental Medicine Oral Diagnosis and Medicine, Department of Oral Pathobiological Science North 13, West 7, Kita-ku Sapporo 060-8586 JapanAyako Harahashi, Hokkaido University, Graduate School of Dental Medicine Oral Diagnosis and Medicine, Department of Oral Pathobiological Science North 13, West 7, Kita-ku Sapporo 060-8586 JapanTsubasa Murata, Hokkaido Universit...

Why women shun science

Guardian Unlimited Science — Tue, 16 Mar 2010 08:30:00 +0100

It's not a lack of ability holding women back in scientific careers but gender-based stereotypingWhat is to blame for the persistent lack of women in the hard sciences and in technology? The New York Times explores what the writer Katrin Bennhold describes as "Risk and opportunity for women in the 21st century". The article explains that the number of women in the sciences has steadily declined, despite record levels of need in areas such as computer engineering and chemical science.This gender-based career stagnation flies in the face of workforce trends that are placing women in increasing roles of prominence and power across all sectors. With the promise of higher income and innovative work, women are certainly wooed by the idea of scientific and technological careers, yet women lag far...

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Strokes, Alzheimer's & The Whole Catastrophe

Psychology Today Personality Center — Tue, 16 Mar 2010 01:27:04 +0100

I began my first novel in seventh grade. It opened with a description of a solitary male figure on a hillside, gazing out to sea, wearing sandals. That was as far as I got in terms of character and plot development before the narrative spontaneously evolved into a discussion of my sock drawer, and how my older brother Harry used to irritate me by opening it without my permission and helping himself to my socks.Some years later I agreed to co-author a novel with that same sock-thief of a brother, entitled November Under my Sole. He wrote the central story, concerning a disgruntled New Yorker named Noah Wilner who decides to wreak havoc on New York City by arranging to import massive quantities of dehydrated elephant waste that he plants in the city's street cleaning machines. Recalling Noah...

Society for Scholarly Publishing 2010 Travel Grant Program

ScanGrants feed — Tue, 16 Mar 2010 00:00:00 +0100

The Board of Directors of the Society for Scholarly Publishing is very pleased to announce its 2010 travel grant program.Students of publishing and information science, together with early career professionals in the first three years of employment in the publishing and information industry, are invited to apply for one of 10 awards that SSP will make in 2010.The awards will support travel to and attendance at the SSP Annual Meeting, which takes place June 2-4, 2010 at the Hilton Union Square Hotel in San Francisco, California.The travel grant program is just one of the ways in which SSP supports training and career development in the scholarly communication professions, while welcoming all members of this community at the SSP Annual Meeting.Successful applicants will be granted free regi...

Factors associated with probability of personal digital assistant-based dietary self-monitoring in those with type 2 diabetes

Journal of Behavioral Medicine — Mon, 15 Mar 2010 17:57:56 +0100

This study examined modifiable and nonmodifiable factors associated with technology-based self-monitoring. 123 participants with type 2 diabetes self-monitored diet using a personal digital assistant in a 6-month behavioral intervention. Multinomial logistic regression was used to examine probability of nonadherent and suboptimally adherent behavior relative to adherent behavior. Sociodemographic characteristics were not associated with probability of self-monitoring. Probability of adherence generally was greater in the weeks preceding no group session, and lower in the weeks following no group session or following skipped sessions. Non-modifiable factors suggested by the literature to be associated with poorer access to technology (lower income, older age, minority race, and lower ...

O6-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma

International Journal of Clinical Oncology — Mon, 15 Mar 2010 17:56:14 +0100

Conclusions Low MGMT expression and MGMT promoter methylation are both predictive markers for slower tumor progression in patients with glioblastoma. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0065-6Authors Yukihiko Sonoda, Tohoku University Graduate School of Medicine Department of Neurosurgery 1-1 Seiryo-machi, Aoba-ku Sendai 980-8574 JapanMichiko Yokosawa, Tohoku University Graduate School of Medicine Department of Neurosurgery 1-1 Seiryo-machi, Aoba-ku Sendai 980-8574 JapanRyuta Saito, Tohoku University Graduate School of Medicine Department of Neurosurgery 1-1 Seiryo-machi, Aoba-ku Sendai 980-8574 JapanMasayuki Kanamori, Tohoku University Graduate School of Medicine Department of Neurosurgery 1-1 Seiryo-machi, Aoba-ku Sendai 980-8...

Inflammatory bowel disease in children: epidemiological analysis of the nationwide IBD registry in Japan

Journal of Gastroenterology — Mon, 15 Mar 2010 17:55:57 +0100

Conclusion The nationwide registry in Japan showed IBD in children has clinical features that are distinct from those in adults. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-010-0223-7Authors Takashi Ishige, Gunma University Graduate School of Medicine Department of Pediatrics 3-39-22 Showa-machi Maebashi Gunma 371-8511 JapanTakeshi Tomomasa, Gunma University Graduate School of Medicine Department of Pediatrics 3-39-22 Showa-machi Maebashi Gunma 371-8511 JapanTohru Takebayashi, Keio University School of Medicine Department of Preventive Medicine and Public Health Tokyo JapanKeiko Asakura, Keio University School of Medicine Department of Preventive Medicine and Public Health Tokyo JapanMamoru Watanabe, Tokyo Medical and Denta...

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Steroidal regulation of Ihh and Gli1 expression in the rat uterus

Cell and Tissue Research — Mon, 15 Mar 2010 17:55:14 +0100

Abstract Ovarian steroid hormones, progesterone (P4), and estradiol (E2) strictly regulate the endometrial tissue remodeling required for successful embryo implantation. Indian hedgehog (Ihh) is up-regulated by P4 and critically mediates uterine receptivity in the mouse. However, the regulation of Ihh expression during the implantation period still remains unclear. The present study was conducted to elucidate the mechanism of the steroidal regulation in the expression of Ihh and Gli1, the mediator of the Ihh pathway. Ihh mRNA was expressed in the rat uterus on 3.5–5.5 days post-coitus (dpc), while Gli1 expression transiently increased at 3.5 dpc but decreased significantly on 5.5 dpc (P < 0.001). In delayed implantation, the expression of Ihh was induce...

A false-negative sentinel lymph node in the parotid gland of a melanoma patient: a new algorithm for SLN biopsy in the parotid gland

International Journal of Clinical Oncology — Mon, 15 Mar 2010 05:32:46 +0100

Abstract The sentinel lymph node (SLN) is the first node in the lymphatic basin to be affected by metastatic tumor cells from a primary lesion. It provides a way to avoid elective neck dissection in a case in which there is no metastasis to the SLN. However, identification and excision of the SLN may be difficult due to the shine-through phenomenon, as the SLN in the parotid gland is either located close to the primary lesion or, in many cases, the lymph node of the parotid gland is small and covered by fibrous capsula. When we conducted an SLN biopsy on a 68-year-old male patient with malignant melanoma of the cheeks, the metastasis to the node of the parotid gland identified as the SLN was negative; however, 1 year later, the melanoma recurred on the lymph node of t...

Repair in osteonecrosis of the femoral head: MR imaging features at long-term follow-up

Clinical Rheumatology — Mon, 15 Mar 2010 05:32:46 +0100

In conclusion, reparative process was limited to the periphery of osteonecrosis over a long period of time unless collapse had occurred. If collapse had ceased minimally, the reconstructive repair process could be facilitated. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10067-010-1404-8Authors Masaki Takao, Osaka University Graduate School of Medicine Department of Orthopaedic Surgery 2-2 Yamadaoka Suita 565-0871 Osaka JapanTakashi Nishii, Osaka University Graduate School of Medicine Department of Orthopaedic Medical Engineering 2-2 Yamadaoka Suita 565-0871 Osaka JapanTakashi Sakai, Osaka University Graduate School of Medicine Department of Orthopaedic Surgery 2-2 Yamadaoka Suita 565-0871 Osaka JapanHideki Yoshikawa, Osaka University Graduate School of Medicin...

Estimation of local statistical noise in PET images induced by attenuation inside the body

Annals of Nuclear Medicine — Mon, 15 Mar 2010 05:32:21 +0100

Conclusions Our algorithm favorably estimated the local statistical noise in PET image data using CT image data, regardless of object size, although the consideration was limited for phantoms with homogeneous interiors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12149-010-0355-0Authors Hideaki Kitamura, National Cancer Center Hospital East Radiology Division Kashiwa JapanKazumasa Inoue, Beth Israel Deaconess Medical Center, Harvard Medical School Division of Hematology and Oncology Boston MA USATatsuya Sasaki, National Cancer Center Hospital East Radiology Division Kashiwa JapanKeisuke Tsuda, Tokyo Metropolitan University Graduate School of Human Health Sciences Tokyo JapanHirotaka Fujimori, National Cancer Center Hospital East Radiology Divisi...

Differentiating specific job knowledge from implicit trait policies in procedural knowledge measured by a situational judgment test.

Journal of Applied Psychology — Mon, 15 Mar 2010 05:00:00 +0100

This study compared validities of situational judgment test (SJT) scoring keys that were presumed to be differentially saturated with specific knowledge about effective job behavior and general knowledge about effective trait expression. The keys were based on subject matter experts’ effectiveness judgments, undergraduates’ effectiveness judgments, and graduate students’ trait judgments. We used data reported earlier by Motowidlo, Dunnette, and Carter (1990) with managerial incumbents in telecommunication companies. All keys yielded valid relations with supervisory performance ratings. The key based on subject matter experts’ judgments, however, explained criterion variance beyond the variance explained by the other keys. These results suggest that specific knowledge about effectiv...

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An economist’s perspective on Shadish (2010) and West and Thoemmes (2010).

Psychological Methods — Mon, 15 Mar 2010 05:00:00 +0100

In Shadish (2010) and West and Thoemmes (2010), the authors contrasted 2 approaches to causality. The first originated in the psychology literature and is associated with work by Campbell (e.g., Shadish, Cook, & Campbell, 2002), and the second has its roots in the statistics literature and is associated with work by Rubin (e.g., Rubin, 2006). In this article, I discuss some of the issues raised by Shadish and by West and Thoemmes. I focus mostly on the impact the 2 approaches have had on research in a 3rd field, economics. In economics, the ideas of both Campbell and Rubin have been very influential, with some of the methods they developed now routinely taught in graduate programs and routinely used in empirical work and other methods receiving much less attention. At the same time, econom...

Health Care: Recession means fewer openings for nurses

bizjournals.com Health Care:Biotechnology headlines — Mon, 15 Mar 2010 04:00:00 +0100

A year ago, Susan Birkhead could be sure that 100 percent of her nursing students would walk out the door after graduation and walk into the job of their choice. (Source: bizjournals.com Health Care:Biotechnology headlines)

Hopkins Nurses to Haiti -- Second Deployment Departs

The Johns Hopkins University School of Nursing - News — Mon, 15 Mar 2010 00:00:00 +0100

3/15/2010 - A second team of Johns Hopkins Nursing graduate students, faculty, alumni, and non-Hopkins nurses left for Haiti on a two-week deployment. (Source: The Johns Hopkins University School of Nursing - News)

Internal medicine residency training for unhealthy alcohol and other drug use: recommendations for curriculum design

BMC Medical Education — Mon, 15 Mar 2010 00:00:00 +0100

We describe and link the content to the core competencies mandated by the Accreditation Council for Graduate Medical Education, the formal accrediting body for residency training programs in the United States. Specific topics are recommended, with suggestions on how to integrate such teaching into existing internal medicine residency training program curricula.SummaryGiven the burden of disease and effective interventions available that can be delivered by internal medicine physicians, teaching about unhealthy substance use must be incorporated into internal medicine residency training, and can be done within existing teaching venues. (Source: BMC Medical Education)

[In Context] Book: Inflammation in the CNS: always as damaging as presumed?

Lancet Neurology — Mon, 15 Mar 2010 00:00:00 +0100

Inflammatory Diseases of the Central Nervous System provides an in-depth understanding of the cross-talk between the brain and the immune system under conditions that include autoimmune and bacterial inflammation. The book covers the major mechanisms in a balanced manner, from basic sciences to clinical implications. There is no doubt that this book can serve as a basic textbook for graduate students and clinicians who seek to understand mechanisms of CNS inflammation and who wish to gain insight that will suggest future avenues of intervention, or explain events associated with existing therapies. Even readers with only a basic background in immunology can benefit greatly from this book. (Source: Lancet Neurology)

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11th Annual Bioinformatics Open Source Conference 2010 Student Travel Awards

ScanGrants feed — Mon, 15 Mar 2010 00:00:00 +0100

Through generous sponsorship from Eagle Genomics and an anonymous donor, we are pleased to announce the competition for three Student Travel Awards for BOSC 2010. Each winner will be awarded $250 to defray the costs of travel to BOSC 2010. To apply for the award, submit your abstract by the April 15 deadline through the Open Conference Systems site. Be sure to check the box indicating that you are a graduate student. Your abstract will undergo the normal review process for BOSC. In addition, the BOSC Organizing Committee will review the student abstracts and pick the three best abstracts for the Student Travel Awards. You will be notified of your award by the abstract notification deadline shown above. You will still need to make your own travel arrangements for BOSC. The award will take ...

Jeffery and Miquette Roberts

Guardian Unlimited Science — Sun, 14 Mar 2010 18:08:19 +0100

My parents Jeffery and Miquette Roberts, who have both died aged 66, within 10 days of each other, shared passions for the arts and languages, and had broad-ranging, inquiring minds. In April 2009, Jeffery was diagnosed with cancer. He faced this with amazing fortitude, and the unending support of Miquette, who died of injuries resulting from a fall shortly after his death.In my father's office were large maps of Russia and Finland, a piano and dictionaries covering various Nordic and Slavic languages. The effect was that of a musically gifted military dictator, combined with an eccentric taxi firm with an enormous catchment area. Jeffery had an avowedly internationalist focus, but his interest in the world was local as well, as shown by his time as a Liberal party councillor in Shoreditch...

Low-density lipoprotein (LDL) apheresis reduces atherogenic and oxidative markers in uremic patients with hyperlipidemia

International Urology and Nephrology — Sun, 14 Mar 2010 12:26:37 +0100

This study aimed to investigate whether LDL apheresis was capable of reducing oxidative and atherogenic markers in uremic patients with hyperlipidemia. We found that oxidative metabolites (methylquanidine, dityrosine, and ox-LDL) and atherogenic markers (lipoprotein (a), LDL, and LDL/HDL ratio) were significantly reduced (P < 0.05) after LDL apheresis. On the other hand, plasma total antioxidant status (TAS) was not influenced after LDL apheresis. Our results suggest that LDL apheresis reduces oxidative and atherogenic markers and do not influence plasma TAS in uremic patients with hyperlipidemia. This may lead to a decreased risk of atherosclerosis in these patients. However, supplementation of dietary proteins may be necessary because of the removal of some “useful�...

Long-term prognosis in ethnic Chinese patients with unprotected left main coronary artery disease

Clinical Research in Cardiology — Sun, 14 Mar 2010 12:25:11 +0100

Conclusion For Chinese patients with unprotected left main coronary artery disease, a significant higher risk of cardiovascular death was noted in the medical therapy group. Overall the long-term cardiovascular survival was similar in LMCA patients treated with either PCI or CABG, but CABG provided better survival outcome in high-risk subgroup patients. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00392-010-0139-5Authors Hui-Chun Huang, National Taiwan University Hospital, National Taiwan University College of Medicine Division of Cardiology, Department of Internal Medicine, Graduate Institute of Clinical Medicine No. 7 Chung-Shan South Road Taipei 100 TaiwanHsien-Li Kao, National Taiwan University Hospital, National Taiwan University College of M...

Thickness of photoreceptor layers in polypoidal choroidal vasculopathy and central serous chorioretinopathy

Graefe's Archive for Clinical and Experimental Ophthalmology — Sun, 14 Mar 2010 11:30:17 +0100

Conclusions Thinning of each photoreceptor layer was observed in the eyes of PCV patients as compared to that observed in the case of normal individuals. The differentiating factors between PCV and CSC, observed using SD-OCT, include the thinning of the OS in eyes with PCV, which makes SD-OCT helpful in differentiating PCV from CSC. More severe photoreceptor alterations were seen in PCV, because fibrin and hemorrhage were present in the subretinal space, which correlated with poorer vision. Content Type Journal ArticleCategory Retinal DisordersDOI 10.1007/s00417-010-1338-5Authors Sotaro Ooto, Kyoto University Graduate School of Medicine Department of Ophthalmology and Visual Sciences 54 Kawahara-cho, Shogoin, Sakyo-ku Kyoto 606-8507 JapanAkitaka Tsujikawa, Kyoto Un...

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Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: a case–control study in an Indian population

Journal of Cancer Research and Clinical Oncology — Sun, 14 Mar 2010 11:26:27 +0100

Conclusions The combined effects of putative risk alleles/genotypes for different DNA repair pathways may strengthen the susceptibility to rectal cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0809-8Authors Jingwen Wang, Nagoya City University Graduate School of Medical Sciences Department of Public Health Mizuho-ku Nagoya 467-8601 JapanYang Zhao, Nagoya City University Graduate School of Medical Sciences Department of Public Health Mizuho-ku Nagoya 467-8601 JapanJing Jiang, The First Hospital, Jilin University Department of Hematology and Oncology Changchun ChinaVendhan Gajalakshmi, Epidemiological Research Center Chennai IndiaKiyonori Kuriki, University of Shizuoka Hygiene and Preventive Medicine, School of Food and Nutritional Sc...

Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins

Breast Cancer Research and Treatment — Sun, 14 Mar 2010 11:26:12 +0100

Abstract Previous studies have demonstrated that the persistent exposure of human bronchial epithelial cells to nicotine (Nic) through nicotinic acetylcholine receptors increases cyclin D1 promoter activity and protein expression. The main purpose of this study is to elucidate the carcinogenic role of cyclin D3, which is involved in breast tumorigenesis when induced by Nic. Real-time PCR analysis revealed that cyclin D3 is highly expressed at the mRNA level in surgically dissected breast tumor tissue, compared to the surrounding normal tissue (tumor/normal fold ratio = 17.93, n = 74). To test whether Nic/nicotinic acetylcholine receptor (nAChR) binding could affect cyclin D3 expression in human breast cancer cells, the transformed cell line MCF-10A-Nic (...

Distribution of sympathetic fiber areas of radial nerve in the forearm: an immunohistochemical study in cadavers

Surgical and Radiologic Anatomy — Sun, 14 Mar 2010 11:25:41 +0100

Conclusions Sympathetic fibers area (Asym) was found to be more in RN when compared to SBRN-1 and SBRN-2. The sympathetic ratio (SI) and percentage of sympathetic fibers area (Asym %) was more in SBRN-1 when compared to RN and SBRN-2. These results of the study might help to explain sympathetic system-related diseases in the area of distribution of RN and SBRN. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00276-010-0648-yAuthors S. Chakravarthy Marx, Kasturba Medical College Department of Anatomy Manipal 576104 Karnataka IndiaPramod Kumar, Kasturba Medical College Department of Plastic Surgery Manipal 576104 Karnataka IndiaS. Dhalapathy, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGI) Department of Endocrine Surgery Lucknow Utt...

Electroencephalographic response following midazolam-induced general anesthesia: relationship to plasma and effect-site midazolam concentrations

Journal of Anesthesia — Sun, 14 Mar 2010 11:25:14 +0100

Conclusion Following the induction of general anesthesia with i.v. midazolam 0.2 or 0.3 mg kg−1, the BIS was positively correlated with the relative beta ratio. Despite a rapid decrease in the plasma and effect-site concentrations of midazolam, the average BIS remained >60 for 60 min after induction, reflecting an increased power of the electroencephalographic high-frequency band. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00540-010-0907-4Authors Wakako Miyake, Osaka City University Graduate School of Medicine Department of Anesthesiology 1-5-7 Asahimachi Abeno-ku, Osaka 545-8586 JapanYutaka Oda, Osaka City University Graduate School of Medicine Department of Anesthesiology 1-5-7 Asahimachi Abeno-ku, Osaka 545-8586 JapanYuk...

Safe and effective sedation in endoscopic submucosal dissection for early gastric cancer: a randomized comparison between propofol continuous infusion and intermittent midazolam injection

Journal of Gastroenterology — Sun, 14 Mar 2010 11:25:07 +0100

Conclusion Based on our results, the ESDs for EGC performed under sedation using propofol continuous infusion were as safe as those performed using intermittent MDZ injection. Propofol-treated patients had a quicker recovery profile than those treated with MDZ. We therefore recommend the use of continuous propofol sedation for ESD, but sedation guidelines for the use of propofol are necessary. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-010-0222-8Authors Shinsuke Kiriyama, National Cancer Center Hospital Department of Endoscopy Tokyo JapanTakuji Gotoda, National Cancer Center Hospital Department of Endoscopy Tokyo JapanHiromi Sano, Cancer Institute Hospital Anesthesiology Department Tokyo JapanIchiro Oda, National Cance...

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History of diabetes mellitus and the risk of prostate cancer: the Ohsaki Cohort Study

Cancer Causes and Control — Sun, 14 Mar 2010 11:24:58 +0100

Conclusion This population-based prospective cohort study indicates that a history of diabetes mellitus is associated with an increased incidence of advanced prostate cancer. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-010-9530-9Authors Qiang Li, Tohoku University Graduate School of Medicine Division of Epidemiology, Department of Public Health and Forensic Medicine 2-1 Seiryo-Machi, Aoba-Ku Sendai, Miyagi 980-8575 JapanShinichi Kuriyama, Tohoku University Graduate School of Medicine Division of Epidemiology, Department of Public Health and Forensic Medicine 2-1 Seiryo-Machi, Aoba-Ku Sendai, Miyagi 980-8575 JapanMasako Kakizaki, Tohoku University Graduate School of Medicine Division of Epidemiology, Department of Public Health and Forensic M...

Recent Public Policy Reports Online at www.aibs.org/public-policy-reports

AIBS News — Sat, 13 Mar 2010 16:05:05 +0100

Public Policy Report for 19 January 2010 Inspector General finds fault with Interior's management of collections. The Inspector General (IG) for the US Department of the Interior (DOI) has "found that DOI is failing to fulfill its stewardship responsibilities over museum collections." In a December 2009 report, the IG found that the DOI has failed to properly accession, catalogue, or inventory museum collections, leaving artifacts "unavailable for research, education, or display" and "subject to theft, deterioration, and damage." New biosecurity measures recommended for US lab. The Working Group on Strengthening Biosecurity of the United States has issued a set of recommendations to improve security at labs that handle dangerous pathogens and select toxins. The interagency working group ...

Epidemiology and management of insomnia in children with autistic spectrum disorders.

Paediatric Drugs — Sat, 13 Mar 2010 00:40:21 +0100

Authors: Miano S, Ferri R Insomnia is the predominant sleep concern in children with autistic spectrum disorder (ASD), and its nature is most likely multifactorial, with neurochemical (abnormalities in serotonergic transmission or melatonin levels), psychiatric (anxiety), and behavioral (poor sleep habits) etiological factors involved. Children with ASD experience sleep problems similar to those of typically developing children, although the prevalence is markedly higher, occurring in 44-83% of school-aged children with ASD. Caregivers usually report that insomnia is the most frequent sleep disorder, described as disorders of initiating and maintaining sleep, restless sleep, bedtime resistance, co-sleeping, alterations of sleep hygiene, and early awakenings in the morning. Many actigra...

Recent Public Policy Reports Online at www.aibs.org/public-policy-reports

AIBS News — Fri, 12 Mar 2010 16:16:50 +0100

Academic awards to women for doctoral research

Fri, 12 Mar 2010 15:42:15 +0100

To promote the interests of women graduates world-wide and to promote women's opportunities in education and public life. The British Federation of Women Graduates gives awards annually to women in their third and final year of doctoral studies. The awards are given on the basis of evidence of academic excellence and are NOT expected to provide for financial need. The amounts offered range upwards from £1000 with the average award being around £3000. The number of awards made each year depends on the funds available and on the quality of the applications but around five or six awards are usually given. The final selection is made in June of each year and awards are given out in September. Applications will close on Friday, March 26th 2010. Please see the website for further informatio...

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Inequality in health care utilization in Germany? Theoretical and empirical evidence for specialist consultation

Journal of Public Health — Fri, 12 Mar 2010 06:51:23 +0100

Discussion The research results suggest the existence of relevant differences in the amount of specialist consultation according to health insurance and other socioeconomic features. Further research could concentrate on the question of whether these inequalities in utilization levels indicate overprovision or underprovision of ambulant health care. Moreover, we recommend longitudinal research that is particularly suited to detangle age and cohort effects. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10389-010-0321-2Authors Stefan Gruber, Institut für Arbeitsmarkt-und Berufsforschung Regensburger Str. 104, 90478 Nürnberg Nuremberg GermanyMarkus Kiesel, Bremen International Graduate School of Social Sciences, Wiener Straße/Celsiusstraße Post...

The Developmental Path to Expertise in Group Psychotherapy

Journal of Contemporary Psychotherapy — Fri, 12 Mar 2010 06:50:31 +0100

Abstract This paper describes a trajectory by which an individual achieves expertise in group psychotherapy. Five developmental stages are posited. In the decisional-anticipatory stage, interest is developed in group psychotherapy. In the trainee stage, the individual masters the knowledge base of group psychotherapy and obtains fledgling experiences in a group. In the novice stage, the individual obtains additional experience in running groups and becomes socialized into a community of group psychotherapists. In the proficiency stage, the individual narrows his or her group psychotherapy focus and obtains more specialized experience in that area. At this time, supervisory and consultation skills are often developed. In the final stage of expertise, the expert must engage ...

Scope, competences, learning outcomes and methods of periodontal education within the undergraduate dental curriculum: A Consensus report of the 1st European workshop on periodontal education – position paper 2 and consensus view 2

European Journal of Dental Education — Fri, 12 Mar 2010 00:00:00 +0100

The explosion in new knowledge in the last three decades has imposed important challenges in the training of all health workers, including dentists. These breakthroughs do not rapidly permeate educational cirricula. This is particularly relevant in Periodontology, because of recent breakthroughs in diagnostics and therapeutic approaches and by the advent of new knowledge on the implications of periodontal and peri-implant infections on systemic health and on ageing populations. Periodontology as one of the major oral health sciences requires a broad understanding of a spectrum of healthcare and basic sciences, together with specific education. In preparation for graduation, students must demonstrate a variety of acquired learning out-comes, which, in turn demand variety in learning and tea...

Biochemistry of the envenomation response - A generator theme for interdisciplinary integration

Biochemistry and Molecular Biology Education — Fri, 12 Mar 2010 00:00:00 +0100

The understanding of complex physiological processes requires information from many different areas of knowledge. To meet this interdisciplinary scenario, the ability of integrating and articulating information is demanded. The difficulty of such approach arises because, more often than not, information is fragmented through under graduation education in Health Sciences. Shifting from a fragmentary and deep view of many topics to joining them horizontally in a global view is not a trivial task for teachers to implement. To attain that objective we proposed a course herein described - Biochemistry of the envenomation response - aimed at integrating previous contents of Health Sciences courses, following international recommendations of interdisciplinary model. The contents were organized by...

Selection Factors Among International Medical Graduates and Psychiatric Residency Performance [BRIEF REPORTS]

Acad Psychiatry — Thu, 11 Mar 2010 19:21:16 +0100

CONCLUSION: Further research is necessary to determine predictive factors related to psychiatric residents’ performance, especially among IMGs. Adjusting current selection criteria may result in better outcomes for training programs and future psychiatrists. (Source: Acad Psychiatry)

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Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata

Journal of Natural Medicines — Thu, 11 Mar 2010 18:26:15 +0100

In this study, we attempted to clarify the antiobesity mechanism and the safety of S. reticulata in vivo and in vitro. We gave ordinary MF feed, alone or mixed with S. reticulata (0.3 or 1.0%), to Tsumura Suzuki obesity diabetes (TSOD) mice (spontaneous obese type II diabetes model mice) and Tsumura Suzuki non-obese (TSNO) mice (the corresponding reference animals), ad libitum for 2 months. As compared with the TSNO control mice, the TSOD control mice became obese due to fat accumulation and developed various signs of metabolic diseases. The TSOD mouse group receiving S. reticulata showed the following effects: suppression of body weight increase and fat accumulation, alleviation of abnormal lipid metabolism and abnormal glucose tolerance, and suppression of intrahepatic fat accu...

Security and Privacy Issues in Wireless Sensor Networks for Healthcare Applications

Journal of Medical Systems — Thu, 11 Mar 2010 18:18:02 +0100

Abstract The use of wireless sensor networks (WSN) in healthcare applications is growing in a fast pace. Numerous applications such as heart rate monitor, blood pressure monitor and endoscopic capsule are already in use. To address the growing use of sensor technology in this area, a new field known as wireless body area networks (WBAN or simply BAN) has emerged. As most devices and their applications are wireless in nature, security and privacy concerns are among major areas of concern. Due to direct involvement of humans also increases the sensitivity. Whether the data gathered from patients or individuals are obtained with the consent of the person or without it due to the need by the system, misuse or privacy concerns may restrict people from taking advantage of the fu...

Enhanced expression of naofen in kidney of streptozotocin-induced diabetic rats: possible correlation to apoptosis of tubular epithelial cells

Clinical and Experimental Nephrology — Thu, 11 Mar 2010 18:14:39 +0100

Conclusions These data suggest that naofen expression may be upregulated by hyperglycemia, with possible correlation to apoptosis of tubular epithelial cells and thereby to diabetic nephropathy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10157-010-0276-1Authors Yuko Sato, Aichi Medical University School of Medicine Department of Anesthesiology Nagakute Aichi-gun Aichi 480-1195 JapanGuo-Gang Feng, Aichi Medical University School of Medicine Department of Pharmacology Nagakute Aichi-gun Aichi 480-1195 JapanLei Huang, Aichi Medical University School of Medicine Department of Pharmacology Nagakute Aichi-gun Aichi 480-1195 JapanJun-Hua Fan, Nagoya University Graduate School of Medicine Department of Gastroenterology 65 Tsuruma-cho, Showa-ku Nagoya A...

In vitro susceptibility to antimicrobial agents and ultrastructural characteristics related to swimming motility and drug action in Campylobacterjejuni and C. coli

Journal of Infection and Chemotherapy — Thu, 11 Mar 2010 18:14:36 +0100

In this study, we examined in vitro susceptibility to 36 antimicrobial agents of 109 strains of C. jejuni and C. coli isolated from chickens and patients with enteritis or Guillain–Barré syndrome from 1996 to 2009. Among these agents, carbapenems (imipenem, meropenem, panipenem, and biapenem) showed the greatest activity [minimal inhibitory concentration (MIC)90, 0.03–0.125 μg/ml]. This was followed by sitafloxacin (MIC90, 0.25 μg/ml), furazolidone and azithromycin (MIC90, 0.5 μg/ml), gentamicin and clindamycin (MIC90, 1 μg/ml), and clavulanic acid (β-lactamase inhibitor; MIC90, 2 μg/ml). All or most strains were resistant to aztreonam, sulfamethoxazole, and trimethoprim. Marked resistance was also observed for levofloxacin and tetracyclines. Resistan...

A case of long-term recurrence-free poorly differentiated neuroendocrine carcinoma of lymph nodes treated by surgical resection without any chemotherapy

International Journal of Clinical Oncology — Thu, 11 Mar 2010 18:14:33 +0100

Abstract A 77-year-old man presented with a 2-month history of an enlarged right inguinal lymph node. Diagnostic excisional biopsy of the inguinal lymph node proved it to be a poorly differentiated neuroendocrine carcinoma by histological and immunohistological analyses. We diagnosed a poorly differentiated neuroendocrine carcinoma by histological examination and immunohistological analysis of the resected inguinal lymph node. We performed computed tomographic examination and positron emission tomography, which identified lymph node involvement without any signs of other tumors. Because these tumors had grown expandingly and had been encapsulated locally, we performed an operation to dissect all of the involved lymph nodes. Direct invasion to the right external iliac arter...

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Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention

International Journal of Clinical Oncology — Thu, 11 Mar 2010 18:14:32 +0100

Abstract Both cigarette smoking and alcohol drinking are well-established risk factors for esophageal squamous cell carcinoma (ESCC), and the relationship of dose to cancer risk has already been described. Furthermore, the synergistic effect of these two factors has been reported. Our case–control study revealed the odds ratio of ESCC to be 50.1 for those who were both heavy smokers and heavy drinkers in comparison to people who neither drank nor smoked. In patients with ESCC, head and neck cancers as well as dysplastic lesions are frequently observed. Heavy smoking and heavy drinking are closely related to such multicentric carcinogenesis events in the upper aerodigestive tract (UADT), including the esophagus and head andneck region. Polymorphisms in acetaldehyde dehydr...

Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus

International Journal of Clinical Oncology — Thu, 11 Mar 2010 18:14:32 +0100

Content Type Journal ArticleCategory Introduction to Review ArticlesDOI 10.1007/s10147-010-0055-8Authors Yoshihiko Maehara, Kyushu University Department of Surgery and Science, Graduate School of Medical Sciences 3-1-1 Maidashi, Higashi-ku Fukuoka 812-8582 Japan Journal International Journal of Clinical OncologyOnline ISSN 1437-7772Print ISSN 1341-9625 (Source: International Journal of Clinical Oncology)

Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis

International Journal of Clinical Oncology — Thu, 11 Mar 2010 18:14:30 +0100

Abstract Esophageal cancer is the eighth most common incident cancer in the world and ranks sixth among all cancers in mortality. Esophageal cancers are classified into two histological types; esophageal squamous cell carcinoma (ESCC), and adenocarcinoma, and the incidences of these types show a striking variety of geographic distribution, possibly reflecting differences in exposure to specific environmental factors. Both alcohol consumption and cigarette smoking are major risk factors for the development of ESCC. Acetaldehyde is the most toxic ethanol metabolite in alcohol-associated carcinogenesis, while ethanol itself stimulates carcinogenesis by inhibiting DNA methylation and by interacting with retinoid metabolism. Cigarette smoke contains more than 60 carcinogens and...

Enhancing the weight training experience: a comparison of limb kinematics and EMG activity on three machines

European Journal of Applied Physiology — Thu, 11 Mar 2010 18:12:30 +0100

Abstract The aim of the study was to compare the kinematics and the timing and amount of electromyographic (EMG) activity during the lat-pull down exercise performed on machines that afforded one, two, or three degrees of freedom for the movement. Seven healthy men (age 29.4 ± 5.6 years) participated in the study. The exercise was performed with a 30% 1-RM load. Three types of machines with varying degrees of freedom were used: Type 1, the conventional device that restricted the movement to a frontal plane; Type 2, the addition of forearm supination–pronation; Type 3, the addition of forearm supination–pronation and horizontal extension–flexion about the shoulder. All exercises involved a technique known as beginning movement load (BML) training in wh...

Early trabeculectomy bleb walls on anterior-segment optical coherence tomography

Graefe's Archive for Clinical and Experimental Ophthalmology — Thu, 11 Mar 2010 18:12:26 +0100

Conclusions Bleb wall reflectivity on AS-OCT 2 weeks after surgery may predict bleb function at 6 months, whereas IOP of developing blebs may not. Content Type Journal ArticleCategory GlaucomaDOI 10.1007/s00417-010-1311-3Authors Noriko Nakano, Kyoto University Graduate School of Medicine Department of Ophthalmology and Visual Sciences 54 Kawahara-cho, Shogoin, Sakyo-ku Kyoto 606-8507 JapanMasanori Hangai, Kyoto University Graduate School of Medicine Department of Ophthalmology and Visual Sciences 54 Kawahara-cho, Shogoin, Sakyo-ku Kyoto 606-8507 JapanHideo Nakanishi, Kyoto University Graduate School of Medicine Department of Ophthalmology and Visual Sciences 54 Kawahara-cho, Shogoin, Sakyo-ku Kyoto 606-8507 JapanRyo Inoue, Kyoto University Graduate School o...

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Positional variations among heterogeneous nucleosome maps give dynamical information on chromatin

Chromosoma — Thu, 11 Mar 2010 18:12:23 +0100

Abstract Although nucleosome remodeling is essential to transcriptional regulation in eukaryotes, little is known about its genome-wide behavior. Since a number of nucleosome positioning maps in vivo have been recently determined, we examined if their comparisons might be used for obtaining a genome-wide profile of nucleosome remodeling. Using seven yeast maps, the local variability of nucleosomes, measured by the entropy, was significantly higher in a set of reported unstable nucleosomes. The binding sites of four transcription factors, known as the remodeling factors, were distinctively high both in entropy and linker ratio, whereas those of Yhp1, their potential inhibitor, showed the lowest values in both of them. Taken together, our map shows the general information of...

Recent Public Policy Reports Online at www.aibs.org/publicpolicy-reports

AIBS News — Thu, 11 Mar 2010 17:42:17 +0100

Wellcome Trust Postdoctoral Training Fellowships for MB/PhD Graduates

Society for Endocrinology — Thu, 11 Mar 2010 12:00:00 +0100

The Wellcome Trust are offering a unique opportunity to newly qualified MB/PhD graduates, or those who have completed a PhD during or before starting their medical degree, to undertake a period of postdoctoral training in the best laboratories in the UK or overseas. These fellowships enable successful candidates to make an early start to an independent research career. The fellowships can be focused on research, or can incorporate clinical training. Candidates should have completed foundation training and have demonstrated significant progress towards gaining the core clinical competences that would be expected of a specialty level trainee or integrated academic training pathway (IATP) academic clinical fellow. For more information, contact Emma Tomlinson: e.tomlinson@wellcome.ac.uk, or ...

A Longitudinal Comparison of Arm Morbidity in Stage I–II Breast Cancer Patients Treated with Sentinel Lymph Node Biopsy, Sentinel Lymph Node Biopsy Followed by Completion Lymph Node Dissection, or Axillary Lymph Node Dissection

Annals of Surgical Oncology — Thu, 11 Mar 2010 08:07:03 +0100

Conclusion Initial declines in range of motion and strength were followed by recovery, although not always to presurgery levels. Range of motion and volume outcomes were better for SLNB than ALND, but not strength. SLNB surpassed SLNB + CLND in 2 of the range of motion variables. The clinical relevance of these results is negligible. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-010-0981-8Authors Jan J. Kootstra, University Medical Center Groningen, University of Groningen Department of Surgical Oncology Groningen The NetherlandsJosette E. H. M. Hoekstra-Weebers, University Medical Center Groningen, University of Groningen Wenckebach Institute Groningen The NetherlandsJohan S. Rietman, Roessingh Research and Development Enschede Th...

Establishing a training programme for rehabilitation aides in Haiti: Successes, challenges, and dilemmas.

Disability and Rehabilitation — Thu, 11 Mar 2010 07:54:03 +0100

Conclusion. The most common difficulties and dilemmas in providing a rehabilitation aide programme were: lack of resources including job opportunities for graduates, and lack of proper support available from supervising healthcare providers. Curricula for similar programs must be culturally sensitive, help create employment opportunities, and provide continuing educational opportunities for their graduates. PMID: 20205579 [PubMed - in process] (Source: Disability and Rehabilitation)

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Who does what on Wikipedia?

EurekAlert! - Social and Behavioral Science — Thu, 11 Mar 2010 05:00:00 +0100

(University of Arizona) The patterns of collaboration between Wikipedia contributors have a direct effect on the data quality of an article, according to a new paper co-authored by a University of Arizona professor and graduate student. (Source: EurekAlert! - Social and Behavioral Science)

Molecular characterization of VP7 gene of human rotaviruses from Bangladesh

Virus Genes — Thu, 11 Mar 2010 02:45:08 +0100

This study was carried out during July 2005–June 2006, to characterize rotaviruses circulating in Bangladeshi children less than 5 years attended a peri-urban hospital. The proportion of rotavirus diarrhea was 39.5%. Genotype G2 was dominant (45.5%) followed by G1 (24.8%), G12 (9.6%), G9 (8.5%), and G4 (2.1%). G2 were mainly in combination with P[4], G1 and G9 with P[8], and G12 with P[6]. Phylogenetically Bangladeshi G1, G2, and G12 were closely related with the respective types from India, whereas Bangladeshi G9s of lineage III were with strains from Belgium and Australia. A G9 strain of lineage IV was clustered with strains from Sri Lanka and Turkey. Compared with prototype rotaviruses, Bangladeshi strains showed several amino acid substitutions at the antigenic sites of VP...

Multiple dermatofibromas in a patient with systemic lupus erythematosus and Sjögren’s syndrome

Modern Rheumatology — Thu, 11 Mar 2010 02:42:09 +0100

We report a case of multiple dermatofibromas in a patient with systemic lupus erythematosus (SLE) and Sjögren’s syndrome. He was treated with prednisolone, diaphenylsulfone, and cyclosporine for SLE. He noticed two brown nodules on his right lower leg 3 years after the first consultation. Subsequently, six nodules developed within 6 months, and 2 more nodules after 10 months. Histopathological examination of a nodule on his left hand showed fibrotic proliferation with a storiform pattern in the whole dermis, but neither necrosis nor mitosis was observed. From these findings, a diagnosis of multiple dermatofibromas was made. As these tumors appeared during the remission stage of SLE, they might have been under immunosuppressive conditions caused by immunosuppressing ...

Combination chemotherapy with weekly paclitaxel or docetaxel, carboplatin, and estramustine for hormone-refractory prostate cancer

Journal of Infection and Chemotherapy — Thu, 11 Mar 2010 02:42:08 +0100

In conclusion, weekly DTX-based chemotherapy was no less effective and less toxic than triweekly DTX-based chemotherapy for HRPC patients and therefore can be useful as the first-line chemotherapy regimen for HRPC patients, especially the elderly or those with a poor performance status. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10156-010-0047-7Authors Tomihiko Yasufuku, Kobe University Graduate School of Medicine Division of Urology, Department of Surgery 7-5-1 Kusunoki-cho, Chuo-ku Kobe 650-0017 JapanKatsumi Shigemura, Kobe University Graduate School of Medicine Division of Urology, Department of Surgery 7-5-1 Kusunoki-cho, Chuo-ku Kobe 650-0017 JapanOsamu Matsumoto, Miki City Hospital Department of Urology Miki JapanSoichi Arakawa, Kobe University Gradua...

A case of dense deposit disease associated with a group A streptococcal infection without the involvement of C3NeF or complement factor H deficiency

Pediatric Nephrology — Thu, 11 Mar 2010 02:41:07 +0100

Abstract A 14-year-old girl presented with acute glomerulonephritis. Tests revealed hypocomplementemia and elevated Antistreptolysin-O titers, and renal biopsy revealed endocapillary and mesangial proliferative glomerulonephritis with double contours of the glomerular basement membrane (GBM). Despite methylprednisolone pulse therapy and the administration of oral prednisolone, overt proteinuria and hypocomplementemia persisted. A second renal biopsy 6 months later confirmed the initial diagnosis of dense deposit disease (DDD) based on electron-dense deposits in the GBM. C3 nephritic factor (C3NeF) and a deficiency of complement factor H (CFH) were not evident. A nephritis-associated plasmin receptor (NAPlr), nephritogenic group A streptococcal antigen, and the plasmin acti...

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Photodynamic therapy alone versus combined with intravitreal bevacizumab for neovascular age-related macular degeneration without polypoidal choroidal vasculopathy in Japanese patients

Graefe's Archive for Clinical and Experimental Ophthalmology — Thu, 11 Mar 2010 02:40:18 +0100

Conclusions Our 12-month results of PDT combined with IVB for Japanese patients with AMD without PCV appeared to be more effective than those of PDT alone with fewer treatments. Content Type Journal ArticleCategory Retinal DisordersDOI 10.1007/s00417-010-1343-8Authors Ryuhei Hara, Kumamoto University Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences 1-1-1 Honjo Kumamoto 860-8556 JapanTakahiro Kawaji, Kumamoto University Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences 1-1-1 Honjo Kumamoto 860-8556 JapanYasuya Inomata, Kumamoto University Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences 1-1-1 Honjo Kumamoto 860-8556 JapanJin Tahara, Kumamoto University Department of...

Orthosiphon grandiflorum has a protective effect in a calcium oxalate stone forming rat model

Urological Research — Thu, 11 Mar 2010 02:38:00 +0100

This study amied to investigate the effects of Orthosiphon grandiflorum on the renal tubular cell injury induced by oxalate and the inhibitory effects of O. grandiflorum on urinary deposit formation in an animal model and compared the results with those from a potassium citrate treatment. Rats were divided into three groups: an untreated stone-forming group, an O. grandiflorum-treated stone-forming group and a potassium citrate-treated stone forming group. Ethylene glycol (0.5%) was administered to the rats during the last week, and vitamin D3 (0.5 μm) was force fed to induce hyperoxaluria and kidney calcium oxalate crystal deposition. Twenty-four hour urine samples were collected before and after inducing crystal deposits. Rats were killed and both kidneys were harvested after 3...

Rigid internal fixation of mandibular fractures using autologous bone grafts: the autologous bone plate

European Journal of Plastic Surgery — Thu, 11 Mar 2010 02:37:58 +0100

Abstract The mandible is the second most commonly fractured part of the maxillofacial skeleton because of its position and prominence. Over the past three decades, many different techniques and approaches have been described in the literature to surgically correct facial fractures. The present study has attempted to study the role of bone grafts in open reduction and internal fixation of mandibular fractures. Fourteen patients with mandibular fracture were considered for the study from August 2006 to August 2008. Autologous bone grafts were used for rigid fixation of these fractures in all the cases. Patients presenting with unilateral fractures of the body of the mandible were considered and enrolled for rigid internal fixation using autologous bone grafts. Fourteen patie...

OCRF Welcomes New CEO, Audra Moran

OCRF News — Thu, 11 Mar 2010 00:00:00 +0100

The Ovarian Cancer Research Fund is pleased to announce the selection of Ms. Audra Moran as its new Chief Executive Officer. She will assume her new position on March 15, 2010.The Ovarian Cancer Research Fund is pleased to announce the selection of Ms. Audra Moran as its new Chief Executive Officer. She will assume her new position on March 15, 2010.Audra brings over 15 years of non-profit leadership and development experience to OCRF. For the past ten years, Audra served as Vice President for Development and Scientific Affairs at NARSAD, the world's largest charity dedicated to mental health research. She oversaw all programmatic, fundraising, and administrative aspects of an annual $20 million international research grant program. She also served as Program Advisor to the Schiz...

American Health Information Management Association Foundation Merit Scholarships

ScanGrants feed — Thu, 11 Mar 2010 00:00:00 +0100

2010 Application Deadline — Friday, April 30, 2010 (11:59 PM CST) EligibilityAHIMA Foundation scholarship basic eligibilty requirements include: * The program the student is enrolled in must be must be accredited by the Commission on Accreditation for Health Informatics and Information Management (CAHIIM). (Want to know if the program is accredited? Visit http://www.cahiim.org/accredpgms.asp). Graduate students must be AHIMA credentialed members pursuing degrees in areas related to HIM practice. * The student must have completed at least 6 credit hours in program coursework before being eligible to apply for a scholarship. In addition, student must have at least one full semester (6 credit hours) of classes remaining in their course of study at the time the award is granted. This ...

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Creating Champions for Health Care Quality and Safety

American Journal of Medical Quality — Wed, 10 Mar 2010 23:43:26 +0100

Patient safety and quality of care are public concerns that demand personal responsibility at all levels of the health care organization. Senior residents in our graduate medical education program took responsibility for a capstone quality improvement project designed to transform them into champions for health care quality. Residents (n = 26) participated alone or in pairs in a 1-month faculty-mentored rotation at the Veterans Administration Hospital during the 2007-2008 academic year. They completed a Web-based curriculum, identified a quality-of-care issue, applied Plan—Do—Study—Act cycles, authored a report, and engaged colleagues in their innovations during a department-wide presentation. Results indicated that residents demonstrated significantly enhanced knowledge ...

Random Forests Classification Analysis for the Assessment of Diagnostic Skill

American Journal of Medical Quality — Wed, 10 Mar 2010 23:43:26 +0100

Mechanisms are needed to assess learning in the context of graduate medical education. In general, research in this regard is focused on the individual learner. At the level of the group, learning assessment can also inform practice-based learning and may provide the foundation for whole systems improvement. The authors present the results of a random forests classification analysis of the diagnostic skill of rheumatology trainees as compared with rheumatology attendings. A random forests classification analysis is a novel statistical approach that captures the strength of alignment of thinking between student and teacher. It accomplishes this by providing information about the strength and correlation of multiple variables. (Source: American Journal of Medical Quality)

Incorporating Cultural Competence Content Into Graduate Nursing Curricula Through Community--University Collaboration

Journal of Transcultural Nursing — Wed, 10 Mar 2010 19:08:24 +0100

Health professionals are reorienting workforce education to better prepare students for working with increasingly diverse populations. The authors describe a community-based curriculum deliberation process in which community leaders and health workers deliberated with faculty and students to make recommendations about a graduate nursing curriculum. There were five areas of competencies recommended for graduate nursing to improve care of diverse populations: self-awareness, basic knowledge of culture and identity, attitudes that promote cross-cultural communication, cross-cultural clinical skills, and advocacy skills. The school now is in the process of phasing in recommendations gained from the deliberation. (Source: Journal of Transcultural Nursing)

Existence of pyogenic spondylitis in Modic type 1 change without other signs of infection: 2-year follow-up

European Spine Journal — Wed, 10 Mar 2010 18:48:31 +0100

Abstract The relationship of Modic change to pain and inflammation remains to be unclear. Recently, some authors have reported that Modic type 1 signals are closely related to infection. However, if the patients do not have severe back pain, fever, or an abnormal blood profile, it is difficult to distinguish between common Modic change and infection. The purpose of this study was to examine the prevalence of pyogenic spondylitis in patients who showed Modic type 1 change without other signs of infection. Seventy-one patients with Modic type 1 change were evaluated (average age 55, 32 males and 39 females). X-ray and magnetic resonance imaging (MRI) were performed to investigate low-back pain and leg pain. Body temperature was measured and blood analysis (including white bl...

Can the caudal extent of fusion in the surgical treatment of scoliosis in Duchenne muscular dystrophy be stopped at lumbar 5?

European Spine Journal — Wed, 10 Mar 2010 18:48:31 +0100

Abstract Instrumentation and fusion to the sacrum/pelvis has been a mainstay in the surgical treatment of scoliosis in Duchenne muscular dystrophy (DMD) and is recommended to correct pelvic obliquity. The caudal extent of instrumentation and fusion in the surgical treatment of scoliosis in DMD has remained a matter of considerable debate, and there have been few studies on the use of segmental pedicle screw instrumentation for this pathology. From 2004 to 2007, a total of 28 patients with DMD underwent segmental pedicle screw instrumentation and fusion only to L5. Assessment was performed clinically and with radiologic measurements. All patients had a curve with the apex at L2 or higher preoperatively. Preoperative coronal curve averaged 74°, with a postoperative mean of ...

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Prescreening of a High-Risk Group for Gastric Cancer by Serologically Determined Helicobacter pylori Infection and Atrophic Gastritis

Digestive Diseases and Sciences — Wed, 10 Mar 2010 18:48:04 +0100

Conclusions A high-risk group for gastric cancer can be selected by serological prescreening. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1154-0Authors Shigeto Mizuno, Kobe Pharmaceutical University Department of Medical Pharmaceutics 4-19-1 Motoyama-kita, Higashinada-ku Kobe 658-8558 JapanIkuya Miki, Kobe Pharmaceutical University Department of Medical Pharmaceutics 4-19-1 Motoyama-kita, Higashinada-ku Kobe 658-8558 JapanTsukasa Ishida, Kobe Pharmaceutical University Department of Medical Pharmaceutics 4-19-1 Motoyama-kita, Higashinada-ku Kobe 658-8558 JapanMasaru Yoshida, Kobe University Division of Gastroenterology, Graduate School of Medicine 7-5-2 Kusunoki-cho, Chuo-ku Kobe 650-0017 JapanMitsuko Onoyama, Kobe University Division of G...

Response to “Use of air in macular hole surgery”

Graefe's Archive for Clinical and Experimental Ophthalmology — Wed, 10 Mar 2010 18:47:27 +0100

Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00417-010-1335-8Authors Yuhei Hasegawa, Kyushu University Department of Ophthalmology, Graduate School of Medical Sciences Fukuoka JapanYasauki Hata, Kyushu University Department of Ophthalmology, Graduate School of Medical Sciences Fukuoka JapanYasutaka Mochizuki, Kyushu University Department of Ophthalmology, Graduate School of Medical Sciences Fukuoka JapanRyoichi Arita, Kyushu University Department of Ophthalmology, Graduate School of Medical Sciences Fukuoka JapanShuhei Kawahara, Kyushu University Department of Ophthalmology, Graduate School of Medical Sciences Fukuoka JapanTakeshi Kita, Kyushu University Department of Ophthalmology, Graduate School of Medical Sciences Fukuoka JapanYoshihiro Noda, Kyushu Univers...

Docosahexaenoic acid status in females of reproductive age with maple syrup urine disease

Journal of Inherited Metabolic Disease — Wed, 10 Mar 2010 18:33:33 +0100

Abstract Individuals with maple syrup urine disease (MSUD) have impaired metabolism of branched-chain amino acids (BCAA) valine, isoleucine, and leucine. Life-long dietary therapy is recommended to restrict BCAA intake and thus prevent poor neurological outcomes and death. To maintain adequate nutritional status, the majority of protein and nutrients are derived from synthetic BCAA-free medical foods with variable fatty acid content. Given the restrictive diet and the importance of omega-3 fatty acids, particularly docosahexaenoic acid (DHA), in neurological development, this study evaluated the dietary and fatty acid status of females of reproductive age with MSUD attending a metabolic camp. Healthy controls of similar age and sex were selected from existing normal labora...

A 38-year review of oral schwannomas and neurofibromas in a Brazilian population: clinical, histopathological and immunohistochemical study

Clinical Oral Investigations — Wed, 10 Mar 2010 18:32:35 +0100

Abstract The benign peripheral nerve sheath tumours are rare lesions mainly represented by schwannoma and neurofibroma. The present work evaluated the clinical and histopathological features of schwannomas and neurofibromas of the oral cavity diagnosed in a Brazilian population. Among 9.000 cases of oral lesions archived from 1970 to 2008, four schwannomas and 12 neurofibromas were identified, microscopically revised and immunohistochemically certified through a panel including monoclonal antibodies (anti-S100, vimentin, HHF-35 and desmin). From biopsy and histological sections records, clinical and histopathological data were retrieved, reviewed and statistically analysed. Predominantly, schwannomas affected non-white males (3:1), with an age and size averages of 34.7&nbs...

Gender modifies the relationship between social networks and smoking among adults in Seoul, South Korea

International Journal of Public Health — Wed, 10 Mar 2010 18:32:20 +0100

Conclusions Social network mechanisms were differentially associated with the high smoking prevalence among men and low prevalence among women and should be targeted by interventions tailored to these differences. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00038-010-0126-7Authors John W. Ayers, Johns Hopkins Bloomberg School of Public Health Department of Health, Behavior and Society Baltimore USAC. Richard Hofstetter, San Diego State University Center for Behavioral Epidemiology and Community Health, Graduate School of Public Health 9245 Sky Park Court, Suite 230 San Diego CA 92123 USASuzanne C. Hughes, San Diego State University Center for Behavioral Epidemiology and Community Health, Graduate School of Public Health 9245 Sky Park Court, Suit...

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New low-field extremity MRI, compacTscan: comparison with whole-body 1.5 T conventional MRI

Modern Rheumatology — Wed, 10 Mar 2010 18:29:49 +0100

Abstract Low-field extremity magnetic resonance imaging (lfMRI) is currently commercially available and has been used clinically to evaluate rheumatoid arthritis (RA). However, one disadvantage of this new modality is that the field of view (FOV) is too small to assess hand and wrist joints simultaneously. Thus, we have developed a new lfMRI system, compacTscan, with a FOV that is large enough to simultaneously assess the entire wrist to proximal interphalangeal joint area. In this work, we examined its clinical value compared to conventional 1.5 tesla (T) MRI. The comparison involved evaluating three RA patients by both 0.3 T compacTscan and 1.5 T MRI on the same day. Bone erosion, bone edema, and synovitis were estimated by our new compact MRI scoring syst...

Plate-like permanent dental laminae of upper jaw dentition in adult gobiid fish, Sicyopterus japonicus

Cell and Tissue Research — Wed, 10 Mar 2010 18:28:43 +0100

Abstract Sicyopterus japonicus (Teleostei, Gobiidae) possesses a unique upper jaw dentition different from that known for any other teleosts. In the adults, many (up to 30) replacement teeth, from initiation to attachment, are arranged orderly in a semicircular-like strand within a capsule of connective tissue on the labial side of each premaxillary bone. We have applied histological, ultrastructural, and three-dimensional imaging from serial sections to obtain insights into the distribution and morphological features of the dental lamina in the upper jaw dentition of adult S. japonicus. The adult fish has numerous permanent dental laminae, each of which is an infolding of the oral epithelium at the labial side of the functional tooth and forms a thin plate-like structure...

Universities Need Funds for Research Infrastructure

Public Policy Reports — Wed, 10 Mar 2010 17:47:46 +0100

A growing backlog of renovation projects at U.S. universities could be hampering American innovation and international competiveness, according to witnesses at a recent House Science and Technology Subcommittee on Research and Science Education hearing. On 23 February 2010, Subcommittee Chairman Daniel Lipinski (D-IL) addressed the need for federal support for renovation and maintenance of academic research facilities. “Successful R&D [research and development] takes more than intellectual freedom and grant funding. You also need state-of-the-art lab space, networks, instruments, and computing facilities. Public institutions especially are suffering as the recession has eroded state support. I am worried that unless we actively modernize our R&D facilities, we could not only...

In the AIBS Webstore

Public Policy Reports — Wed, 10 Mar 2010 17:47:46 +0100

In the AIBS Webstore

Public Policy Reports — Wed, 10 Mar 2010 17:47:46 +0100

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Racial/Ethnic Differences in Seroadaptive and Serodisclosure Behaviors Among Men Who Have Sex with Men

AIDS and Behavior — Wed, 10 Mar 2010 16:23:20 +0100

We examined racial/ethnic differences in reported seroadaptive and serodisclosure behaviors among the partnerships of MSM recruited for a cross-sectional survey using time-location sampling (TLS) in San Francisco during 2007–2008. The sample (N = 1,199) consisted of 12.2% Asian/Pacific Islander (API), 52.4% White, 6.8% Black, 20.2% Latino, and 8.5% of “other” race/ethnicity. Pure serosorting was most common (about 20%) among HIV-negative men while seropositioning was most used (about 15%) by HIV-positive men. Reported seroadaptive behaviors did not differ significantly across races/ethnicities among both HIV-negative and HIV-positive men. However, HIV-positive Black and Latino men were significantly more likely to report no preventive, seroadaptive behavioral strategy ...

Diurnal differences in memory and learning in young and adult rats treated with methylphenidate

Journal of Neural Transmission — Wed, 10 Mar 2010 16:21:24 +0100

Abstract Methylphenidate (MPH) is a very effective treatment option for children and adolescents with attention-deficit/hyperactivity disorder. Nevertheless, there have been inconsistent reports regarding the effects of MPH on learning and memory. The aim of this study was to evaluate whether the treatment with MPH during the morning differs from that during the night on learning and memory (short and long term) in young and adult male Wistar rats. The animals received once daily intraperitoneal injection of either MPH (2 mg/kg) or saline (0.9%) for 28 days (either in the morning or at night). The animals underwent two behavioral tasks to evaluate learning and memory: inhibitory avoidance task and continuous multiple trials step-down inhibitory avoidance (CMIA). ...

Cervical kyphosis with myelopathy and anomalous vertebral artery entry at C7 treated with pedicle screw and rod fixation

Acta Neurochirurgica — Wed, 10 Mar 2010 16:19:23 +0100

Content Type Journal ArticleCategory Letter to the editorDOI 10.1007/s00701-010-0618-5Authors Masashi Yamazaki, Chiba University Graduate School of Medicine Spine Section, Department of Orthopaedic Surgery 1-8-1 Inohana, Chuo-ku Chiba 260-8677 JapanAkihiko Okawa, Chiba University Graduate School of Medicine Spine Section, Department of Orthopaedic Surgery 1-8-1 Inohana, Chuo-ku Chiba 260-8677 JapanTakeo Furuya, Chiba University Graduate School of Medicine Spine Section, Department of Orthopaedic Surgery 1-8-1 Inohana, Chuo-ku Chiba 260-8677 JapanMasao Koda, Chiba University Graduate School of Medicine Spine Section, Department of Orthopaedic Surgery 1-8-1 Inohana, Chuo-ku Chiba 260-8677 Japan Journal Acta NeurochirurgicaOnline ISSN 0942-0940Print ISSN 0001-6268 (Source: Acta Neu...

Simple analysis of blonanserin, a novel antipsychotic agent, in human plasma by GC-MS

Forensic Toxicology — Wed, 10 Mar 2010 16:18:45 +0100

Abstract Blonanserin is a novel antipsychotic agent having dopamine D2 and serotonin 5-HT2A receptor antagonist properties. In this communication, a simple method for analysis of blonanserin in human plasma by gas chromatography-mass spectrometry (GC-MS) using hexobarbital as internal standard (IS) is presented. One milliliter of plasma containing blonanserin and 50 ng of IS was mixed well with 0.5 ml of 0.1 M hydrochloric acid and 2.5 ml of distilled water; the mixture was applied to an Oasis HLB cartridge. The cartridge was washed with 5 ml of distilled water, and the target compound and IS were eluted with 2 ml of chloroform. The eluate was evaporated to dryness under a stream of nitrogen. The residue was reconstituted in 50 μl of methanol for use in GC-MS analysis. The...

An Emergency Medical Communications System by Low Altitude Platform at the Early Stages of a Natural Disaster in Indonesia

Journal of Medical Systems — Wed, 10 Mar 2010 16:14:05 +0100

Abstract A natural disaster is a consequence of a natural hazard, such as a tsunami, earthquake or volcanic eruption, affecting humans. In order to support emergency medical communication services in natural disaster areas where the telecommunications facility has been seriously damaged, an ad hoc communication network backbone should be build to support emergency medical services. Combinations of requirements need to be considered before deciding on the best option. In the present study we have proposed a Low Altitude Platform consisting of tethered balloons combined with Wireless Fidelity (WiFi) 802.11 technology. To confirm that the suggested network would satisfy the emergency medical service requirements, a communications experiment, including performance service meas...

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Prolonged long-term survival of low-grade endometrial stromal sarcoma patients with lung metastasis following treatment with medroxyprogesterone acetate

International Journal of Clinical Oncology — Wed, 10 Mar 2010 16:13:27 +0100

Conclusion The patients in this study demonstrate that MPA treatment may extend the survival of patients with LGESS that is metastatic to the lung. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0040-2Authors Kentaro Nakayama, Shimane University School of Medicine Department of Obstetrics and Gynecology 89-1 Enyacho Izumo 693-8501 JapanMasako Ishikawa, Shimane University School of Medicine Department of Obstetrics and Gynecology 89-1 Enyacho Izumo 693-8501 JapanYutaka Nagai, University of the Ryukyus Department of Obstetrics and Gynecology, Faculty of Medicine 207 Uehara, Nishihara Okinawa 903-0215 JapanNobuo Yaegashi, Tohoku University Graduate School of Medicine Department of Obstetrics and Gynecology 1-1 Seiryo-machi, Aoba-ku Sendai 98...

Hydroxyurea as an inhibitor of hepatitis C virus RNA replication

Archives of Virology — Wed, 10 Mar 2010 16:03:44 +0100

Abstract Hepatitis C virus (HCV) is the main causative agent of chronic liver disease, which may develop into liver cirrhosis and hepatocellular carcinoma. By using a recently developed reporter assay system in which genome-length HCV RNA replicates efficiently, we found that hydroxyurea (HU), a DNA synthesis inhibitor, inhibited HCV RNA replication. Moreover, we demonstrated that the anti-HCV activity of the combination of IFN-alpha and HU was higher than that of IFN-alpha alone. These results suggest that HU may be an effective anti-HCV reagent that can be used not only singly but also in combination with IFN-alpha to treat chronic hepatitis C. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s00705-010-0624-1Authors Akito Nozaki, Yokohama City Universi...

Retrospective clinical study of the efficacy of lower-dose methotrexate and infliximab therapy in patients with rheumatoid arthritis

Clinical Rheumatology — Wed, 10 Mar 2010 16:01:37 +0100

The objective of this study is to compare the long-term outcomes of infliximab therapy with lower-dose methotrexate (MTX; ≤4 mg per week) and with standard-dose MTX (≥6 mg per week) in Japanese rheumatoid arthritis (RA) patients. One hundred thirty-eight patients with refractory RA were treated with intravenous infliximab; 106 patients underwent lower-dose MTX therapy, and 32 patients underwent standard-dose MTX therapy. Treatment responses at 54 weeks or last observation carried forward (LOCF) assessed using the European League Against Rheumatism (EULAR) response criteria were compared between the two groups. Eighty-eight patients (81.1%) in the lower-dose MTX group and 27 patients (84.3%) in the standard-dose MTX therapy completed 54 weeks of infliximab trea...

Improved Results of a Surgical Resection for the Recurrence of Hepatocellular Carcinoma After Living Donor Liver Transplantation

Annals of Surgical Oncology — Wed, 10 Mar 2010 16:00:52 +0100

Conclusions Surgical therapy might be useful for patients who experience a recurrence of HCC after LDLT to improve their outcome, when such treatment is available. Content Type Journal ArticleCategory Hepatobiliary TumorsDOI 10.1245/s10434-010-0999-yAuthors Akinobu Taketomi, Kyushu University Department of Surgery and Science, Graduate School of Medicine 3-1-1 Maidashi Higashi-ku Fukuoka JapanTakasuke Fukuhara, Kyushu University Department of Surgery and Science, Graduate School of Medicine 3-1-1 Maidashi Higashi-ku Fukuoka JapanKazutoyo Morita, Kyushu University Department of Surgery and Science, Graduate School of Medicine 3-1-1 Maidashi Higashi-ku Fukuoka JapanHiroto Kayashima, Kyushu University Department of Surgery and Science, Graduate School of Medicine 3-1-1 ...

CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples

Journal of Neuro-Oncology — Wed, 10 Mar 2010 16:00:42 +0100

This study evaluated the role of CDC25 phosphatases in human glioma proliferation. Upregulation of CDC25A was observed in human glioma specimens and human glioma cell lines. Comparison of expression levels of CDC25A and CDC25B messenger ribonucleic acid (RNA) to Ki-67 labeling index in glioma tissues found that Ki-67 labeling index was significantly correlated with the expression of CDC25A, but not with that of CDC25B. Depletion of CDC25A by small interfering RNA and inhibition of CDC25 suppressed cell proliferation and induced apoptosis in glioma cell lines, indicating that CDC25A is a potential target for the development of new therapy for glioma. Content Type Journal ArticleCategory Laboratory Investigation - Human/Animal TissueDOI 10.1007/s11060-010-0147-3Authors Yoji Yamas...

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Toward Understanding Errors in Inpatient Psychiatry: A Qualitative Inquiry

Psychiatric Quarterly — Wed, 10 Mar 2010 15:58:55 +0100

Abstract While prior research has identified the impact, nature, and causes of medical error in general medical settings, little is known about errors in inpatient psychiatry. Understanding the broad range of errors that occur in inpatient psychiatry is a critical step toward improving systems of care for a vulnerable patient population. An explorative qualitative analysis of key informant interviews identified a preliminary typology of errors and the contextual factors that precipitate them in inpatient psychiatry. The types of errors and their contextual factors fall broadly within the rubric of categories identified in medicine and surgery. However, many of the specific errors and contextual factors manifest themselves differently and are shaped by the uniqueness of the...

Inhibition of degranulation and cytokine production in bone marrow-derived mast cells by hydrolyzed rice bran

Inflammation Research — Wed, 10 Mar 2010 15:37:30 +0100

Conclusions These findings suggest that HRB may have an anti-inflammatory effect by inhibiting mast cell degranulation and cytokine production. Content Type Journal ArticleCategory Original Research PaperDOI 10.1007/s00011-010-0173-9Authors Yuka Hoshino, Nagoya City University Graduate School of Pharmaceutical Sciences 3-1 Tanabe-dori, Mizuho-ku Nagoya 467-8603 JapanNaohide Hirashima, Nagoya City University Graduate School of Pharmaceutical Sciences 3-1 Tanabe-dori, Mizuho-ku Nagoya 467-8603 JapanMamoru Nakanishi, Aichi-Gakuin University School of Pharmacy 1-100 Kusumoto-cho, Chikusa-ku Nagoya 464-8650 JapanTadahide Furuno, Aichi-Gakuin University School of Pharmacy 1-100 Kusumoto-cho, Chikusa-ku Nagoya 464-8650 Japan Journal Inflammation ResearchOnline ISSN 1420...

Parents’ Experiences in Choosing a Health Plan for Their Children with Special Health Care Needs

Maternal and Child Health Journal — Wed, 10 Mar 2010 15:34:34 +0100

Abstract To investigate the information sources, and the perceived helpfulness of each source, that parents used when choosing a health plan for their children with special health care needs (CSHCN) and to determine how parents’ perceptions varied by their sociodemographic characteristics and their children’s enrollment status (newly versus previously enrolled). In Florida, a cross sectional study was carried out using 2007 telephone survey data from 500 parents. Sixty-three percent of parents used at least one information source to choose a health plan for their CSHCN. More parents used the Help Line, yet more parents found it to be the least helpful resource. Multivariate analyses suggest that Hispanic parents were 79% more likely and parents of prior enrollees were ...

Surgery for ulcerative colitis in 1,000 patients

International Journal of Colorectal Disease — Wed, 10 Mar 2010 15:33:50 +0100

Conclusion A restorative proctocolectomy with an IPAA is a safe procedure, with low rates of mortality and major morbidity. We do not recommend routine application of IPAA in any subset of patients with known CD. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-010-0915-8Authors Hiroki Ikeuchi, Hyogo College of Medicine Department of Surgery 1-1 Mukogawa-cho Nishinomiya Hyogo 663-8501 JapanMotoi Uchino, Hyogo College of Medicine Department of Surgery 1-1 Mukogawa-cho Nishinomiya Hyogo 663-8501 JapanHiroki Matsuoka, Hyogo College of Medicine Department of Surgery 1-1 Mukogawa-cho Nishinomiya Hyogo 663-8501 JapanToshihiro Bando, Hyogo College of Medicine Department of Surgery 1-1 Mukogawa-cho Nishinomiya Hyogo 663-8501 JapanTakayuki Matsumoto, Hy...