MedWorm: Medical Training Application Service

The use of melting curves as a novel approach for validation of real-time PCR instruments.

BioTechniques — Thu, 01 Sep 2011 04:00:00 +0100

In this study, high resolu- tion melting curve (HRM) analysis is presented as a novel validation method for real-time PCR instruments. By ap- plying HRM analysis using a defined PCR amplicon and EvaGreen dye, information about the temperature accuracy and thermal homogeneity of the heating block was obtained. This pilot study shows the potential of our technique for temperature validation of real-time quantitative PCR thermal cyclers. Our data correlated well with the tempera- ture accuracy data obtained from the Mobile Temperature Acquisition System (MTAS; r2 = 0.93), which conforms to the National Institute of Standards and Technology criteria, and our method was reproducible in independent runs (r2 = 0.95). The advantages of this HRM-based method include: (i) temperature measurement und...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Phase I Trials of Molecularly Targeted Agents: Should We Pay More Attention to Late Toxicities? [Phase I and Clinical Pharmacology]

Journal of Clinical Oncology — Thu, 28 Apr 2011 23:00:00 +0100

Conclusion Moderate and severe toxicities occur regularly after the first cycle in phase I trials of MTAs and may deserve increased attention in the RP2D process for these agents. (Source: Journal of Clinical Oncology)

Multiple target loci assembly sequencing (mTAS).

Analytical Biochemistry — Fri, 15 Apr 2011 23:00:00 +0100

Authors: Han H, Yoon JK, Cho BC, Kim H, Bang D Here we present multiple target loci assembly sequencing (mTAS), a method for examining multiple genomic loci in a single DNA sequencing read. The key to the success of mTAS target sequencing is the uniform amplification of multiple target genomic loci into a single DNA fragment using polymerase cycling assembly (PCA). Using this strategy, we successfully collected multiloci sequence information from a single DNA sequencing run. We applied mTAS to examine 29 different sets of human genomic loci, each containing from 2 to 11 single-nucleotide polymorphisms (SNP) present at different exons. We believe mTAS can be used to reduce the cost of Sanger sequencing-based genetic analysis. PMID: 21536013 [PubMed - as supplied by publisher] (Sourc...

Mechanism of MT-facilitated Nuclear Import [Cell Biology]

Journal of Biological Chemistry — Thu, 14 Apr 2011 23:00:00 +0100

Although the microtubule (MT) cytoskeleton has been shown to facilitate nuclear import of specific cancer-regulatory proteins including p53, retinoblastoma protein, and parathyroid hormone-related protein (PTHrP), the MT association sequences (MTASs) responsible and the nature of the interplay between MT-dependent and conventional importin (IMP)-dependent nuclear translocation are unknown. Here we used site-directed mutagenesis, live cell imaging, and direct IMP and MT binding assays to map the MTAS of PTHrP for the first time, finding that it is within a short modular region (residues 82–108) that overlaps with the IMPβ1-recognized nuclear localization signal (residues 66–108) of PTHrP. Importantly, fluorescence recovery after photobleaching experiments indicated that disruption of t...

pH, Calcium Ion Release, and Setting Time of an Experimental Mineral Trioxide Aggregate–based Root Canal Sealer

Journal of Endodontics — Wed, 13 Apr 2011 23:00:00 +0100

Conclusions: MTAS presented favorable properties for its indication as a root canal sealer. (Source: Journal of Endodontics)

Heterogeneity in the definition of dose-limiting toxicity in phase I cancer clinical trials of molecularly targeted agents: A review of the literature

European Journal of Cancer — Sun, 10 Apr 2011 23:00:00 +0100

Conclusions: While our results do not support a standardisation of the definition of DLT, the inclusion of following specifications in its definition when relevant would reduce the heterogeneity observed across trials: (1) DLT assessment period, (2) absolute severity according to NCI CTCAE classification as well as severity relative to baseline status, (3) minimum duration of toxicity, (4) reversibility of toxicity within a certain period of time, and (5) necessity to delay treatment or to reduce dose-intensity. (Source: European Journal of Cancer)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Peripheral neuropathy with microtubule-targeting agents: occurrence and management approach.

Clinical Genitourinary Cancer — Thu, 31 Mar 2011 23:00:00 +0100

Authors: Carlson K, Ocean AJ Microtubule-targeting agents (MTAs), which include vinca alkaloids, taxanes, and the recently introduced epothilone, ixabepilone, are widely used chemotherapeutic agents for treatment of patients with cancer. MTAs interfere with the normal structure and function of microtubules, leading to cell-cycle arrest and tumor cell death. Microtubule function is critical to normal neuronal function, thus MTA therapy is commonly associated with some form of neuropathy. There is poor agreement between tools for clinical assessment of MTA-associated peripheral neuropathy, and standardization of grading scales is needed to reduce variability. For a majority of patients, MTA-associated neuropathy is mild to moderate in intensity and reversible, but it can be severe and re...

Juniors needed support over MMC/MTAS

BMJ Online First — Tue, 01 Mar 2011 00:00:00 +0100

(Source: BMJ Online First)

Mitosis is not a key target of microtubule agents in patient tumors

Nature Clinical Practice Oncology — Tue, 01 Feb 2011 00:00:00 +0100

Authors: Edina Komlodi-Pasztor, Dan Sackett, Julia Wilkerson & Tito Fojo Mitosis-specific agents have, to date, not been clinically successful. By contrast, microtubule-targeting agents (MTAs) have a long record of success, usually attributed to the induction of mitotic arrest. Indeed, it was this success that led to the search for mitosis-specific inhibitors. We believe the clinical (Source: Nature Clinical Practice Oncology)

Bacterial leakage in root canals filled with conventional and MTA‐based sealers

International Endodontic Journal — Fri, 28 Jan 2011 00:00:00 +0100

Conclusions All sealers evaluated allowed bacterial leakage. The MTA‐based sealers had the most leakage. (Source: International Endodontic Journal)

Evaluation of the dimensional changes of mineral trioxide aggregate sealer

International Endodontic Journal — Mon, 24 Jan 2011 00:00:00 +0100

Conclusions The novel sealer based on MTA demonstrated adequate setting time and was dimensionally stable. It has the potential to be used as root canal sealer cement in clinical practice. (Source: International Endodontic Journal)

MedWorm Sponsor Message: Find the best January Sales in the UK.

A Response to Rome: Lessons from pre- and post-publication data-sharing in the C. elegans research community

BMC Genomics - Latest articles — Thu, 16 Dec 2010 00:00:00 +0100

Conclusions: The greater scientific community is likely to benefit from understanding the factors that motivate C. elegans researchers to share. In this sense, our research is a 'response' to calls for a greater amount of sharing in other research communities, such as the mouse community, specifically, the call for increased investment and support of centralized resource sharing infrastructure, grant-based funding of data-sharing, clarity of third party recommendations regarding sharing, third party insistence of post-publication data sharing, a decrease in patenting and restrictive MTAs and increased attribution and reward. (Source: BMC Genomics - Latest articles)

Analysis of Arsenic in Gray and White Mineral Trioxide Aggregates by Using Atomic Absorption Spectrometry

Journal of Endodontics — Fri, 15 Oct 2010 00:00:00 +0100

Conclusions: The present in vitro studies demonstrated that there is no threat to patient health in using commercially available brands of MTA for endodontic practices. (Source: Journal of Endodontics)

Dynamic sealing ability of MTA root canal sealer

International Endodontic Journal — Tue, 13 Jul 2010 23:00:00 +0100

Conclusions The novel sealer based on mineral trioxide aggregate had comparable sealing ability to a proprietary brand sealer cement. In contact with a simulated body fluid, the MTA sealer released calcium ions in solution that encouraged the deposition of calcium phosphate crystals. (Source: International Endodontic Journal)

The effect of modernising medical careers on foundation doctor career orientation in the northern ireland foundation school.

The Ulster Medical Journal — Sat, 01 May 2010 00:00:00 +0100

CONCLUSIONS: Despite introducing MMC with a coordinated UK wide specialty application process (MTAS), a detrimental effect on their career orientation was not evident. Pragmatic career choices based on lifestyle may be the reason why female doctors expressed a preference for care of the elderly and paediatrics while their male colleagues favoured acute, more surgically biased specialties. PMID: 21116421 [PubMed - in process] (Source: The Ulster Medical Journal)

Analyses of Heavy Metals in Mineral Trioxide Aggregate and Portland Cement

Journal of Endodontics — Mon, 22 Mar 2010 00:00:00 +0100

Conclusions: Both MTAs released more arsenic than the amount specified in ISO 9917-1 (2007). Portland cements and MTAs showed evidence of heavy metals in the acid-soluble form as well as leaching in deionized water and SBF. MTA contained levels of arsenic higher than the safe limit specified by the ISO 9917-1 (2007). (Source: Journal of Endodontics)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Effect of Mineral Trioxide Aggregates and Portland Cements on Inflammatory Cells

Journal of Endodontics — Mon, 08 Mar 2010 00:00:00 +0100

Conclusion: MTAs were more biocompatible; however, more studies are required. (Source: Journal of Endodontics)

Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.

Biochemical Pharmacology — Tue, 02 Mar 2010 00:00:00 +0100

In conclusion, results from this study highlight the potential of these novel series of PBOX compounds, alone or in sequential combination with flavopiridol, as an effective therapy against CML. PMID: 20206141 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)

Impact of ultrasonic power density on hot water elution of severely biodegraded heavy oil from weathered soils.

Chemosphere — Tue, 09 Feb 2010 00:00:00 +0100

Authors: Ji G, Guo F An ultrasound-enhanced elution system using water at a temperature of 70 degrees C was employed to remove severely biodegraded heavy oil (SBHO) from weathered soil. The effect of varying the ultrasonic power density from 0 to 100WL(-1) on the elution of SBHO and three characteristic biomarkers (C(26-34) 17alpha 25-norhopanes, C(26-28) triaromatic steroids (TAS), and C(27-29) methyl triaromatic steroids (MTAS) was analyzed using GC/MS, scanning electron microscopy (SEM), and X-ray diffraction (XRD). The amount of SBHO and biomarkers present in the treated soils and eluent had significant negative correlation with increasing ultrasonic power density. Elution of the three biomarkers was closely related to the number of C atoms in the marker: C(26-34) 17alpha 25-norhop...

The Biomineralization Ability of Mineral Trioxide Aggregate and Portland Cement on Dentin Enhances the Push-out Strength

Journal of Endodontics — Mon, 07 Dec 2009 00:00:00 +0100

Conclusion: It was concluded that the biomineralization process positively influenced the push-out bond strength of the cements, particularly the MTA groups. (Source: Journal of Endodontics)

Kinetics of apatite formation on a calcium-silicate cement for root-end filling during ageing in physiological-like phosphate solutions

Clinical Oral Investigations — Fri, 27 Nov 2009 07:03:51 +0100

This study evaluated surface morphology and chemical transformations of an experimental accelerated calcium-silicate cement as a function of soaking time in different phosphate-containing solutions. Cement discs were immersed in Dulbecco’s phosphate-buffered saline (DPBS) or Hank’s balanced salt solution (HBSS) for different times (1–180 days) and analysed by scanning electron microscopy connected with an energy dispersive X-ray analysis (SEM-EDX) and micro-Raman spectroscopy. SEM-EDX revealed Ca and P peaks after 14 days in DPBS. A thin Ca- and P-rich crystalline coating layer was detected after 60 days. A thicker multilayered coating was observed after 180 days. Micro-Raman disclosed the 965-cm−1 phosphate band at 7 days only on samples stored in DPB...

MedWorm Sponsor Message: Find the best January Sales in the UK.

CYT997 Causes apoptosis in human multiple myeloma

Investigational New Drugs — Wed, 11 Nov 2009 19:27:58 +0100

Summary Multiple Myeloma (MM) is an incurable malignancy of mature plasma cells. Microtubule targeting agents (MTAs) are an established class of drug that include many conventional and some novel compounds. MTAs function by inhibiting the polymerisation or depolymerisation of microtubules (MTs) within the cell, disrupting various important cellular functions. We have investigated pre-clinically the novel tubulin polymerisation inhibitor CYT997 for the potential treatment of MM. Here we demonstrate the promising anti-myeloma activity of CYT997 as evidenced by tubulin disruption, inhibition of growth and proliferation, cell cycle arrest and most importantly apoptosis of both human myeloma cell lines (HMCLs) and primary MM cells using nanomolar drug concentrations. CYT997 als...

A bad time to get sick?

NHS News Feed — Wed, 23 Sep 2009 16:12:00 +0100

This study was carried out by Dr Min Jen and colleagues from the Dr Foster Unit and other academic departments at Imperial College in London. The Dr Foster Unit is funded by a grant from Dr Foster Intelligence, an independent health service research organisation, and has indirect support from the National Institute of Health Research. The study was published in the peer-reviewed medical journal PLoS ONE. What kind of scientific study was this? The aim of this retrospective cohort study was to compare survival between a group of patients admitted as an emergency on the last Wednesday in July and the first Wednesday in August. The August date corresponds with a week that hospitals typically take on trainee doctors. The researchers reviewed hospital records from the Hospital Episode Statis...

Conflating MTAs and patents

Nature Biotechnology — Wed, 10 Jun 2009 05:00:59 +0100

Nature Biotechnology 27, 504 (2009). doi:10.1038/nbt0609-504b Author: Kevin E Noonan (Source: Nature Biotechnology)

Reply to Conflating MTAs and patents

Nature Biotechnology — Wed, 10 Jun 2009 05:00:59 +0100

Nature Biotechnology 27, 505 (2009). doi:10.1038/nbt0609-505 (Source: Nature Biotechnology)

Simulators improve skills of trainee surgeons

OnMedica Latest News — Fri, 15 May 2009 23:13:06 +0100

Skills enhanced by 50% and operating times halved by simulator useRelated items from OnMedicaNew training programme threatens patient care, say doctorsCMO's regret over medical training too little too lateDiabetes medics have less time for patients1 August, all changeMPs to look into training reforms and MTAS (Source: OnMedica Latest News)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Psychological Impact of Systemic Training Failure On Mental Health and Career Satisfaction of UK Trainees: Lessons From an Online Attitudes Survey.

The International Journal of Social Psychiatry — Fri, 27 Feb 2009 09:57:08 +0100

CONCLUSION: At the onset of MMC, MTAS applicants reported negative process experiences, psychological distress and poor coping (including increased alcohol use), with possible implications for mental health, career planning and patient care. PMID: 19240207 [PubMed - in process] (Source: The International Journal of Social Psychiatry)

Psychological Impact of Systemic Training Failure On Mental Health and Career Satisfaction of UK Trainees: Lessons From an Online Attitudes Survey

International Journal of Social Psychiatry — Tue, 24 Feb 2009 05:00:00 +0100

Conclusion: At the onset of MMC, MTAS applicants reported negative process experiences, psychological distress and poor coping (including increased alcohol use), with possible implications for mental health, career planning and patient care. (Source: International Journal of Social Psychiatry)

Management of Obstructive Sleep Apnea with a Mandibular and Tongue Advancement Splint (MTAS) in a Completely Edentulous Patient. A Clinical Report

Journal of Prosthodontics — Fri, 06 Feb 2009 05:00:00 +0100

Treatment of obstructive sleep apnea (OSA) in dentate patients using a mandibular advancement splint (MAS) from mandibular repositioners has been documented in detail. Nevertheless, studies about completely edentulous patients with OSA are sparse. This clinical report describes a clinical and laboratory method for producing a functional splint combining an MAS and a tongue-retaining device with an individualized tongue tip housing and discusses the rationale for using such a device. (Source: Journal of Prosthodontics)

Comparison of Mineral Trioxide Aggregate's Composition with Portland Cements and a New Endodontic Cement.

Journal of Endodontics — Tue, 27 Jan 2009 15:59:15 +0100

Authors: Asgary S, Eghbal MJ, Parirokh M, Ghoddusi J, Kheirieh S, Brink F The aim of this study was to compare the compositions of mineral trioxide aggregates (MTAs), Portland cements (PCs), and a new endodontic cement (NEC). Our study also investigated the surface characteristics of MTA and NEC root-end fillings when immersed in normal saline. For part I, we prepared samples of 9 brands of MTAs, PCs, and NEC. The materials were imaged and analyzed by scanning electron microscopy (SEM) and energy dispersive x-ray analysis (EDXA). In part II, 3-mm-deep root-end preparations were filled with MTA or NEC and stored in normal saline for 1 week. Samples were imaged and analyzed by SEM and electron probe microanalysis (EPMA). EDXA investigations revealed differences in the dominant compounds ...

Computer glitch swaps junior doctors' exam results

Telegraph Health — Fri, 16 Jan 2009 16:53:06 +0100

Computer systems running the junior doctors' training application system have broken down swapped candidates qualifications and allowed them to see each other's answers. (Source: Telegraph Health)

MedWorm Sponsor Message: Find the best January Sales in the UK.

GMC rejects calls for inquiry into MTAS

E-Health-Insider — Wed, 07 Jan 2009 00:00:05 +0100

The General Medical Council has rejected calls for it to investigate the IT and selection procedures for Modernising Medical Careers. (Source: E-Health-Insider)

PPARγ Inhibitors as Novel Tubulin-Targeting Agents

PPAR Research — Tue, 03 Jun 2008 22:26:03 +0100

The microtubule-targeting agents (MTAs) are a very successful class of cancer drugs with therapeutic benefits in both hematopoietic and solid tumors. However, resistance to these drugs is a significant problem. Current MTAs bind to microtubules, and/or to their constituent tubulin heterodimers, and affect microtubule polymerization and dynamics. The PPARγ inhibitor T0070907 can reduce tubulin levels in colorectal cancer cell lines and suppress tumor growth in a murine xenograft model. T0070907 does not alter microtubule polymerization in vitro, and does not appear to work by triggering modulation of tubulin RNA levels subsequent to decreased polymerization. This observation suggests the possible development of antimicrotubule drugs that work by a novel mechanism, and implies the pre...

Antibodies Incorporated

Drug Development Technology — Mon, 02 Jun 2008 00:00:00 +0100

is a long standing manufacturer of antibodies, antibody based diagnostic kits and reagents under its own label and as a contract manufacturer. Through its long history in the industry it has established not only a sterling reputation as a high quality, rapid response producer of antibodies, but as a versatile, teamwork oriented service provider. We adhere to the strict quality guidelines of ISO 13485 as certified by BSI. NEUROMABS MONOCLONAL ANTIBODIES We are currently the exclusive distributor of NeuroMabs. These are a series of high quality, fully characterized monoclonal antibodies that can be used for research purposes within the research community, including the pharmaceutical industry, biotech, or other research institutions, as long as they are willing to supply us with appropria...

Stress, lies and red tape: the views, success rates and stress levels of the MTAS cohort.

J R Soc Med AND (has... — Sun, 01 Jun 2008 04:00:00 +0100

Conclusions MTAS was a flawed system. A considerable proportion (36%) of candidates who had been on a Senior House Officer training scheme were left without a training post after MTAS. The system seems to favour UK/EEA applicants. Applicants suffered significant psychological distress during and after the MTAS process. PMID: 18515779 [PubMed - in process] (Source: J R Soc Med AND (has...)

Involvement of Sensory Input from Anterior Teeth in Deglutitive Tongue Function

Dysphagia — Sat, 31 May 2008 07:05:45 +0100

Abstract Swallowing is a reflex that receives sensory information from the peripheral nerves and from the cerebral cortex. The aim of the present study was to investigate whether the sensory input from anterior teeth affects the functional characteristics of tongue pressure applied against the hard palate during swallowing. Subjects were eight healthy volunteers. Tongue pressure against the hard palate during swallowing 10 ml of water was measured under two conditions: preanesthesia and postanesthesia of anterior teeth. The sensory deprivation of anterior teeth was performed by periodontal anesthesia. Tongue pressure was measured using a multiple tactile array sensor (MTAS) with eight sensor channels arranged in tandem. The duration of the tongue pressure production during...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Stress, lies and red tape: the views, success rates and stress levels of the MTAS cohort

JRSM — Fri, 30 May 2008 04:00:00 +0100

[Clinical Trials] Nomograms to Predict Serious Adverse Events in Phase II Clinical Trials of Molecularly Targeted Agents

Journal of Clinical Oncology — Thu, 06 Mar 2008 05:00:00 +0100

Conclusion A regression model was constructed that predicts the SAE and SAEatt risk for an individual patient during cycle 1 of phase II trial treatment with moderate to good internal validity. External validation is still required. (Source: Journal of Clinical Oncology)

[Correspondence] MTAS fiasco: further shortlisting issues

Psychiatric Bulletin — Fri, 29 Feb 2008 05:00:00 +0100

(Source: Psychiatric Bulletin)

Full Tooke report now available

MEDEV News — Sun, 13 Jan 2008 05:00:00 +0100

The full report of the Independent Inquiry into Modernising Medical Careers (MMC) in the wake of the debacle surrounding MTAS, is now available to download as a PDF from the MMC website. (Source: MEDEV News)

National IT system needed for medical recruitment

E-Health-Insider — Thu, 10 Jan 2008 17:00:00 +0100

In his final report into the Modernising Medical Careers scheme, Sir John Tooke has labelled the online Medical Training Application Service (MTAS) as a 'crisis, which has revealed profound concerns about the new system of medical postgraduate training.' (Source: E-Health-Insider)

MedWorm Sponsor Message: Find the best January Sales in the UK.

DH found guilty on MTAS data protection breach

E-Health-Insider — Thu, 20 Dec 2007 10:30:00 +0100

The Information Commissioner's Office has found the Department of Health in breach of the Data Protection Act following an investigation into a security breach in the Medical Training Application Service (MTAS) website, and warns the department faces potential prosecution. (Source: E-Health-Insider)

Medical Security Breach Is A Scandal That Must Never Be Repeated - BMA UK

Health News from Medical News Today — Thu, 20 Dec 2007 09:00:00 +0100

The Information Commissioner's Office yesterday warned the Department of Health of possible future prosecutions following a security breach earlier in the year on the Medical Training Application Service (MTAS) website. Mr Ram Moorthy, chairman of the BMA Junior Doctors Committee, says: "This was a scandal that must never be repeated. [click link for full article] (Source: Health News from Medical News Today)

DH found guilty on MTAS data protection breach

EHI Primary Care — Thu, 20 Dec 2007 00:15:00 +0100

Microtubules in apoptosis induction: are they necessary?

Current Cancer Drug Targets — Sat, 01 Dec 2007 05:00:00 +0100

Authors: Estève MA, Carré M, Braguer D Microtubule-Targeting Agents (MTAs) constitute a class of drugs largely used in cancer treatment. Among them, both taxanes and Vinca-alkaloids are known to inhibit cancer cell proliferation by inducing cell cycle arrest and subsequent apoptosis. These agents modify the cytoskeleton by affecting the tubulin/microtubule system. In cancer cells, both classes suppress microtubule dynamics through inhibition of microtubule dynamic instability and treadmilling, and commonly induce diverse signals responsible for cell death initiation and execution via the mitochondrial intrinsic pathway. However, links between microtubule network disturbance and the involvement of mitochondria in apoptosis are not obvious, and one may think that they could be ...

Selection into specialty training in public health: performance of the Medical Training Application Service shortlisting

Journal of Public Health — Mon, 12 Nov 2007 05:00:00 +0100

Conclusion MTAS shortlisting undertaken in two independent public health specialty training programmes discriminated well between appointable and not appointable candidates. (Source: Journal of Public Health)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

British Medicine "Leaderless"

Public Health News From Medical News Today — Wed, 31 Oct 2007 08:00:00 +0100

British medicine is blighted by "self-interested, ineffective, squabbling" bodies incapable of providing the leadership it so desperately needs. Writing in this month's edition of the Journal of the Royal Society of Medicine, Dr Richard Smith, former editor of the BMJ , argues that the "wreckage" left by MTAS* and MMC*, is a result of the lack of "coherent, strategic, high level leadership". [click link for full article] (Source: Public Health News From Medical News Today)

[Education & training] MTAS fiasco: lessons for psychiatry

Psychiatric Bulletin — Wed, 31 Oct 2007 04:00:00 +0100

AIMS AND METHODS The recent Medical Training Application System (MTAS) has been fraught with problems. A survey of MTAS applicants from two London training schemes and a request for emails from trainees and trainers documenting problems with the system were undertaken with the aim of canvassing the views of candidates and shortlisters/interviewers about MTAS, and providing evidence of the system’s failings. RESULTS A total of 101 candidates responded to the survey, and the first 92 emails sent to the Royal College of Psychiatrists were analysed. The majority of respondents (73%) were dissatisfied with MTAS and 63% thought the system unfair. UK and European Economic Area (EEA) applicants (71%) were more successful in being shortlisted than non-EEA candidates (48%). The ...

British Medicine Is Blighted By "Self-Interested, Ineffective, Squabbling" Bodies Incapable Of Providing The Leadership It So Desperately Needs, UK

Public Health News From Medical News Today — Fri, 26 Oct 2007 08:00:00 +0100

Writing in this month's edition of the Journal of the Royal Society of Medicine, Dr Richard Smith, former editor of the BMJ , argues that the "wreckage" left by MTAS* and MMC*, is a result of the lack of "coherent, strategic, high level leadership". A body which could provide leadership for the whole profession would necessarily require the existing professional groups to surrender some of their independence - which Dr Smith recognises will not be a popular option. [click link for full article] (Source: Public Health News From Medical News Today)

MTAS 'rushed and poorly communicated'

E-Health-Insider — Tue, 09 Oct 2007 00:00:03 +0100

The Department of Health has officially dropped the use of a national IT system in favour of locally-led recruitment for specialty training, following publication of the Tooke inquiry, which found the Medical Training Application Service (MTAS) was "rushed and poorly communicated." (Source: E-Health-Insider)

MTAS replaced by local selection process in 2008

OnMedica Latest News — Thu, 04 Oct 2007 10:12:51 +0100

Interim solution includes local selection, no centralised computer or cap on number of applications (Source: OnMedica Latest News)

MedWorm Sponsor Message: Find the best January Sales in the UK.

MTAS online recruitment portal to be dropped

EHI Primary Care — Wed, 03 Oct 2007 13:19:09 +0100

Recruitment to specialist training posts in England next year is set to be handled locally rather than nationally, with the national recruitment portal to be abandoned next year. (Source: EHI Primary Care)

Scotland's Junior Doctors Outline Way Forward For Recruitment But Warn Of Impending Problems For Next Year

Health News from Medical News Today — Tue, 02 Oct 2007 09:00:00 +0100

The views of Scotland's junior doctors on the way forward for recruitment to specialty training in Scotland for 2008 and beyond will today be presented to the Scottish Government. BMA Scotland is keen to ensure that the disasters of this year's MTAS and MMC system*, which caused months of confusion and uncertainty for many junior doctors, are not repeated. [click link for full article] (Source: Health News from Medical News Today)

Government Proposals To Prevent Another Training Disaster Inadequate, Warns BMA, UK

Medical Students News From Medical News Today — Thu, 27 Sep 2007 23:00:00 +0100

Proposals to prevent a repeat of this year's 'MTAS'* medical training disaster are unsatisfactory, the BMA says yesterday. It warns that any computer system to recruit junior doctors in future must be "tested to destruction", and says there should be no limit on the number of applications they can make. The English Department of Health is currently consulting on a new system to select junior doctors for specialist training in England in 2008. [click link for full article] (Source: Medical Students News From Medical News Today)

UK Medical Unemployment Due To Government Policy On Medical Immigration

Health News from Medical News Today — Fri, 21 Sep 2007 07:00:00 +0100

Rather than blaming unemployment among UK medical graduates on MTAS, a failed computerized recruitment system, an article in the British Medical Journal (BMJ) explains that the problem has been caused by the government's policy on medical immigration. [click link for full article] (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

'No alternative' to MTAS system likely for 2008

EHI Primary Care — Mon, 17 Sep 2007 12:35:00 +0100

Remedy UK, the group set up in the wake of the junior doctors' job crisis earlier this year, has called for a return to a paper-based, local system for the 2008 round of recruitment to training posts. (Source: EHI Primary Care)

No alternative to MTAS computer system likely by 2008

E-Health-Insider — Mon, 17 Sep 2007 12:00:00 +0100

BMA demands inquiry into "real" cost of MTAS

OnMedica Latest News — Thu, 06 Sep 2007 11:18:42 +0100

National Audit Office urged to investigate medical training disaster (Source: OnMedica Latest News)

Targeting microtubules to inhibit angiogenesis and disrupt tumour vasculature: implications for cancer treatment.

Current Cancer Drug Targets — Sat, 01 Sep 2007 04:00:00 +0100

Authors: Pasquier E, André N, Braguer D Anticancer agents that interfere with tubulin functions are widely used in the clinic and have a broad spectrum of activity against both haematological malignancies and solid tumours. These Microtubule-Targeting Agents (MTAs), such as the taxanes and Vinca alkaloids, bind to the beta subunit of alpha/beta tubulin and disrupt microtubule dynamics in tumour cells, ultimately leading to mitotic block and subsequent cell death. Recently, MTAs have received considerable interest as potential tumour-selective anti-angiogenic and vascular-disrupting agents. Angiogenesis is a keystone of tumour progression and metastasis and targeting the formation of new blood vessels within the tumour is therefore regarded as a promising strategy for cancer therap...

RSM events launches online video lectures

RSM Members news — Wed, 08 Aug 2007 09:39:00 +0100

You can now see our first online lectures: "Stevens Lecture: Mishaps in Medicine: will we ever learn?" Presented by Professor Sir John Lilleyman on Monday 14 May 2007 "Living with Mtas", Presented by Professor The Baroness Finlay of Llandaff on Saturday 7 July. (Source: RSM Members news)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Academy Recommends Changes In Academic Medical Training In Response To Modernising Medical Careers Enquiry, UK

Public Health News From Medical News Today — Fri, 27 Jul 2007 08:00:00 +0100

An Academy of Medical Sciences working group, chaired by Professor Patrick Maxwell, Academy Registrar, has published a response to the review of Modernising Medical Careers (MMC). The paper expresses broad concerns over the implementation of MMC via the Medical Training Applications Service (MTAS) and makes recommendations for changes in the Clinical Academic career pathway throughout the training grades. [click link for full article] (Source: Public Health News From Medical News Today)

MPs to look into training reforms and MTAS

OnMedica Latest News — Thu, 26 Jul 2007 13:32:04 +0100

The Health Select Committee has announced that it will be investigating the implementation of MMC and scrutinising the role of all those involved (Source: OnMedica Latest News)

Sixteen Thousand Junior Doctors Chasing 2,300 Posts - BMA Responds, UK

Medical Students News From Medical News Today — Sat, 14 Jul 2007 08:00:00 +0100

Figures released by the Department of Health in England last thursday show that 85% of training posts advertised through the Medical Training Application Service were filled in the first round of recruitment. The figure for academic trainee posts was significantly lower, with 57% filled. In a second round of applications, now underway, 2,300 training posts are available for the 16,000 candidates for posts in England who have not yet been appointed. [click link for full article] (Source: Medical Students News From Medical News Today)

Point: MTAs are the bane of our existence!

Nature Biotechnology — Tue, 10 Jul 2007 05:24:06 +0100

Nature Biotechnology 25, 721 (2007). doi:10.1038/nbt0707-721b Author: Katharine Ku (Source: Nature Biotechnology)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Counterpoint: MTAs are a practical necessity

Nature Biotechnology — Tue, 10 Jul 2007 05:24:06 +0100

Nature Biotechnology 25, 722 (2007). doi:10.1038/nbt0707-722 Author: James Henderson (Source: Nature Biotechnology)

Second Round Of Junior Doctor Job Applications Being Rendered Meaningless, Warns BMA, UK

Health News from Medical News Today — Tue, 03 Jul 2007 08:00:00 +0100

Junior doctors who have not found a job through the disastrous Medical Training Application Service (MTAS) are being forced to go through the same discredited process again, the BMA warns. A second round of job applications is now underway. The outgoing Health Secretary Patricia Hewitt, said it would be "based on a revised short-listing and interview process, which will include a structured CV". [click link for full article] (Source: Health News from Medical News Today)

Junior Doctor Tells Of Job Application Despair, BMA News, UK

Medical Students News From Medical News Today — Sat, 30 Jun 2007 08:00:00 +0100

The junior doctor who heckled former secretary Patricia Hewitt on BBC1's Question Time has told of his heartbreak over the failed recruitment process. London SHO in cardiology Philip Smith said his passionate and emotional heckling of Ms Hewitt last month as she attempted to defend the flawed MTAS (medical training application service) was prompted by anger, despair and fear that things would get worse. [click link for full article] (Source: Medical Students News From Medical News Today)

MMC Was An 'Untested Experiment' That 'Bears Little Resemblance' To The Original Principles Of The Reform, Says BMA Scotland

Health News from Medical News Today — Wed, 27 Jun 2007 08:00:00 +0100

BMA Scotland delivered a damning verdict on the UK implementation of Modernising Medical Careers (MMC), the programme of reform of junior doctors' training. It comes as BMA Scotland published its evidence to an independent review of the disastrous medial training application system (MTAS) which has left many junior doctors facing an uncertain future. [click link for full article] (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Junior doctors could sue over MTAS chaos

OnMedica Latest News — Tue, 19 Jun 2007 12:27:44 +0100

BMA issues legal advice and presses for new complaints process (Source: OnMedica Latest News)

The Royal College of Psychiatrists welcomes the Government's decision to abandon the MTAS process

CEBMH News | News Front Page — Tue, 12 Jun 2007 10:00:00 +0100

Royal College of Psychiatrists (RCP) (Source: CEBMH News | News Front Page)

Consultants set for angry annual conference

OnMedica Latest News — Fri, 01 Jun 2007 12:25:05 +0100

Doctors could demand disciplinary action against MTAS architects. (Source: OnMedica Latest News)

The Royal College of Psychiatrists welcomes the Government's decision to abandon the MTAS process

CEBMH News | News Front Page — Tue, 29 May 2007 10:00:00 +0100

Royal College of Psychiatrists (RCP) (Source: CEBMH News | News Front Page)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

"A Dreadful Mess" - BMA Responds To High Court Judgment On MTAS, UK

Public Health News From Medical News Today — Sat, 26 May 2007 19:00:00 +0100

The High Court described the MTAS system used to appoint junior doctors to specialist training as a "dreadful mess", adding that its premature introduction had "disastrous consequences". It also ruled that the review group set up to make improvements to MTAS did not act unlawfully. The claimant, Remedy UK, has decided not to appeal. [click link for full article] (Source: Public Health News From Medical News Today)

Extra training posts for junior doctors not enough

OnMedica Latest News — Fri, 25 May 2007 12:08:01 +0100

Announcement of new posts falls short of tackling the MTAS chaos. (Source: OnMedica Latest News)

MTAS Crisis - BMA Steps Up Pressure On Government, UK

Public Health News From Medical News Today — Thu, 24 May 2007 19:00:00 +0100

The senior leaders of the BMA today renew their pressure on the government in the fight for junior doctors' careers. In a message to the medical profession, the BMA deputy chairman, and the chairmen of all its main committees, announce a series of urgent steps they believe the government needs to take to address the continuing crisis affecting medical training. [click link for full article] (Source: Public Health News From Medical News Today)

Remedy UK loses High Court battle

OnMedica Latest News — Thu, 24 May 2007 12:15:05 +0100

Pressure group vows to continue to help sort out the MTAS mess. (Source: OnMedica Latest News)

MedWorm Sponsor Message: Find the best January Sales in the UK.

BMA chairman resigns over MTAS affair

EHI Primary Care — Mon, 21 May 2007 13:05:10 +0100

The chairman of the British Medical Association, James Johnson, resigned from his position last night following criticism of his handling of the BMA's response to the botched Medical Training Application System (MTAS). (Source: EHI Primary Care)

BMA chairman resigns over MTAS chaos

OnMedica Latest News — Mon, 21 May 2007 12:42:51 +0100

James Johnson, the chairman of the BMA, has resigned following a row caused by the new recruitment system for junior doctors. (Source: OnMedica Latest News)

Irreparable Harm May Be Caused To 10,000 Junior Doctors By MTAS

Medical Students News From Medical News Today — Mon, 21 May 2007 10:00:00 +0100

A group of Doctors from across the UK have expressed fears that the careers of 10,000 junior doctors could be irreparably damaged because of the disastrous mistakes in the Medical Training and Application Service (MTAS). Their concerns are stated in a Comment published early Online and in the upcoming edition of The Lancet. [click link for full article] (Source: Medical Students News From Medical News Today)

The Royal College Of Psychiatrists Welcomes The Government's Decision To Abandon The MTAS Process, UK

Psychology / Psychiatry News From Medical News Today — Fri, 18 May 2007 08:00:00 +0100

The Royal College of Psychiatrists welcomes the Government's decision to abandon the MTAS process. The medical training application service (MTAS) system used to match junior doctors to specialist training posts has been shelved by ministers. Instead, the recruitment process will be CV-based, and handled at a local level by medical deaneries. [click link for full article] (Source: Psychology / Psychiatry News From Medical News Today)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

BMA Welcomes Abandonment Of MTAS, UK

Public Health News From Medical News Today — Thu, 17 May 2007 19:00:00 +0100

The Health Secretary announced today that MTAS (the Medical Training Application Service) will not be used to match candidates to training posts for the remainder of the junior doctor recruitment system. Responding to the announcement, Dr Andrew Rowland, vice chairman of the BMA Junior Doctors Committee, says: "The Department of Health has at last seen sense and effectively abandoned the unfair, discredited, and shambolic MTAS system. [click link for full article] (Source: Public Health News From Medical News Today)

MTAS Will Cause Irreparable Harm To 10 000 Junior Doctors, The Lancet - UK

Medical Students News From Medical News Today — Wed, 16 May 2007 08:00:00 +0100

A group of doctors from across the UK have expressed fears that the careers of 10 000 junior doctors could be irreparably damaged because of the disastrous mistakes in the Medical Training and Application Service (MTAS). Their concerns are stated in a Comment published early Online and in the upcoming edition of The Lancet. [click link for full article] (Source: Medical Students News From Medical News Today)

Recruitment shake-up for medics axed amid fears for patients

Scotsman.com News - Health of the NHS — Tue, 15 May 2007 23:33:47 +0100

THE government was yesterday forced to abandon its controversial new recruitment system for junior doctors. Patricia Hewitt, the Westminster health secretary, said the Medical Training Application Service (MTAS) would no longer be used to match junior... (Source: Scotsman.com News - Health of the NHS)

Information Commissioner to investigate MTAS leak

EHI Primary Care — Thu, 10 May 2007 00:01:48 +0100

The Information Commissioner has told the Liberal Democrat's health spokesperson, Norman Lamb that he will be launching an immediate investigation into the leak of applicant's details on the Medical Training and Application Service website, E-Health Insider has learned. (Source: EHI Primary Care)

Some Good News For Northern Ireland's Junior Doctors

Medical Students News From Medical News Today — Tue, 08 May 2007 19:00:00 +0100

The British Medical Association in Northern Ireland has sought and received today, 3rd May 2007, assurance that all junior doctor interviews for training posts here will be held on a completely equitable basis. The BMA's NI junior doctors committee (NIJDC) is currently working with the DHSSPS to resolve the very serious problems caused by the new electronic application process for junior doctor training posts, (MTAS), put in place earlier this year. [click link for full article] (Source: Medical Students News From Medical News Today)

BMA Demands Assurances Over MTAS Security Breaches, UK

Medical Students News From Medical News Today — Wed, 02 May 2007 08:00:00 +0100

In response to the Health Secretary's statement in the House of Commons on the breaches of security on the MTAS website, Emily Rigby, Chair of the BMA's Medical Students Committee, said: "Patricia Hewitt may be confident that no-one inappropriately accessed the personal information of applicants on the MTAS website but medical students aren't. She can't say for certain no criminal offences were committed - no-one can, not until the investigation is complete. [click link for full article] (Source: Medical Students News From Medical News Today)

BMA Chairman Warns Prime Minister Of Doctors' Anger Over Training Debacle, UK

Public Health News From Medical News Today — Tue, 01 May 2007 11:00:00 +0100

The chairman of the BMA warns the Prime Minister that doctors' anger will grow if the government does not address problems with the Medical Training Application Service (MTAS) "with the level of urgency they deserve." The letter to Tony Blair from Mr James Johnson, Chairman of Council at the BMA, is published as action on MTAS is debated at the BMA's annual conference of junior doctors (Saturday 28 April, 2007 in London). [click link for full article] (Source: Public Health News From Medical News Today)

BMA Condemns Appalling Breach Of Students' Confidentiality, UK

Medical Students News From Medical News Today — Sat, 28 Apr 2007 19:00:00 +0100

Responding to reports that sensitive information about medical students applying for their first jobs through the Medical Training Application Service (MTAS) could be accessed by anyone looking at the MTAS website,Dr Jo Hilborne, chairman of the BMA Junior Doctors Committee, says:"What little faith anyone had left in this shambolic system has just evaporated. It is a breach of security on an appalling scale. [click link for full article] (Source: Medical Students News From Medical News Today)

Immigration Snub No Joke For British Doctor

Public Health News From Medical News Today — Fri, 27 Apr 2007 20:00:00 +0100

A Surrey-born doctor was told his application for specialist training was withdrawn because he did not have the 'correct immigration status'. The London-based junior doctor Hua Luk could not believe it when he received an email from the beleaguered medical training application service saying he could not continue his training. He said: 'I thought it was a joke because it's just preposterous. I was born in Surrey and went to Cambridge University. [click link for full article] (Source: Public Health News From Medical News Today)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Junior doctor's training application almost rejected

OnMedica Latest News — Fri, 27 Apr 2007 12:45:48 +0100

British doctor mistaken for being foreign almost rejected by MTAS. (Source: OnMedica Latest News)

Junior doctors' confidential details openly displayed

EHI Primary Care — Fri, 27 Apr 2007 11:35:00 +0100

The Medical Training Application Service website will be the subject of a Department of Health investigation after an undercover reporter found that the private details of over 1,000 junior doctor applicants were available to view on the website. (Source: EHI Primary Care)

Junior doctors confidential information openly displayed

EHI Primary Care — Fri, 27 Apr 2007 00:05:00 +0100

Junior doctors' confidential details openly displayed

E-Health-Insider — Fri, 27 Apr 2007 00:00:03 +0100

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

BMA Requests Urgent Meeting With Health Secretary As Junior Doctors Prepare To Head Overseas, UK

Public Health News From Medical News Today — Wed, 25 Apr 2007 19:00:00 +0100

The BMA has requested an urgent meeting with the Health Secretary after conducting new research showing that over 50% of junior doctors are likely to leave the UK if their applications for jobs through the flawed Medical Training Application Service (MTAS) are unsuccessful. It was reported over the weekend that NHS Employers believes there are 10,000 more applicants than places available and is considering options for doctors who are at risk of unemployment. [click link for full article] (Source: Public Health News From Medical News Today)

Leaked Paper Shows Need For Government Action On Training Posts, Says BMA, UK

Public Health News From Medical News Today — Wed, 25 Apr 2007 19:00:00 +0100

Commenting on reports that NHS employers is looking at options for thousands of doctors who are at risk of not getting a training post through the Medical Training Application Service (MTAS), Dr Jo Hilborne, chairman of the BMA Junior Doctors Committee, says: "It's extremely worrying that NHS managers do not know how many posts are available for the thousands of junior doctors applying for them. [click link for full article] (Source: Public Health News From Medical News Today)

BMA Requests Urgent Meeting With Health Secretary As Junior Doctors Prepare To Head Overseas, UK

Health News from Medical News Today — Wed, 25 Apr 2007 19:00:00 +0100

Leaked Paper Shows Need For Government Action On Training Posts, Says BMA, UK

Health News from Medical News Today — Wed, 25 Apr 2007 19:00:00 +0100

Commenting on reports that NHS employers is looking at options for thousands of doctors who are at risk of not getting a training post through the Medical Training Application Service (MTAS), Dr Jo Hilborne, chairman of the BMA Junior Doctors Committee, says: "It's extremely worrying that NHS man [click link for full article] (Source: Health News from Medical News Today)

Royal College Of Physicians Of London's President's Update On MTAS

Public Health News From Medical News Today — Fri, 06 Apr 2007 07:00:00 +0100

The President's email bulletin to all Fellows and Members:"The serious concerns about MTAS and MMC remain top of the agenda for all UK consultants and trainees, and so I think it is appropriate to use this regular e-bulletin exclusively for an update on important developments today. [click link for full article] (Source: Public Health News From Medical News Today)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Agreement reached for junior doctor job applicants in England

OnMedica Latest News — Thu, 05 Apr 2007 12:10:19 +0100

Doctors' leaders and the government have finally thrashed out an agreement for junior doctors' job applications in England, following the furore sparked by the new online recruitment and selection process (MTAS). (Source: OnMedica Latest News)

BMA Responds To New Junior Doctor Recruitment And Selection Proposals, UK

Public Health News From Medical News Today — Wed, 04 Apr 2007 16:00:00 +0100

Representatives from the BMA were back at the review group table today (4/3/07) when a revised plan for resolving the Medical Training Application Service (MTAS) crisis was announced. Junior Doctors Committee (JDC) chairman, Dr Jo Hilborne, and Consultants Committee Chairman, Dr Jonathan Fielden, attended this morning's review group meeting to seek further improvements to the new recruitment and selection process for junior doctors in England. [click link for full article] (Source: Public Health News From Medical News Today)

British Medical Association pledges help to junior doctors as 4500 jobs go missing

News-Medical News Feed — Tue, 03 Apr 2007 22:00:00 +0100

The British Medical Association (BMA) is to advise junior doctors on their options if they are not appointed to a new job through the discredited Medical Training Application Service (MTAS). (Source: News-Medical News Feed)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

BMA Pledges Help To Junior Doctors As 4500 Jobs Go Missing, UK

Public Health News From Medical News Today — Tue, 03 Apr 2007 19:00:00 +0100

The BMA is to advise junior doctors on their options if they are not appointed to a new job through the discredited Medical Training Application Service (MTAS). The pledge comes as a new BMA analysis of figures on the MTAS website shows that the actual number of UK specialist training posts available is 18,518* - not between 22,000 and 23,000 as the government has publicly indicated. [click link for full article] (Source: Public Health News From Medical News Today)

BMA Junior Doctors Leave Talks On Recruitment System, UK

Public Health News From Medical News Today — Sat, 24 Mar 2007 14:00:00 +0100

The BMA's Junior doctors Committee (JDC) has withdrawn from the review group trying to resolve failures of the Medical Training Application Service (MTAS). The decision was made because the latest solutions proposed in the group were unacceptable to the JDC. Under the proposed solution doctors would be restricted to one interview. BMA research indicates that this could disadvantage over 11,000 doctors who have been offered more than one interview. [click link for full article] (Source: Public Health News From Medical News Today)

Junior doctors pull out of job application talks

OnMedica Latest News — Fri, 23 Mar 2007 15:34:20 +0100

The BMA has pulled out of talks on the Medical Training Application Service (MTAS) because the solution proposed last night by the review group would have restricted doctors to one interview. (Source: OnMedica Latest News)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Modernising Medical Careers (MMC) Or Mass Medical Culling?

Health News from Medical News Today — Sun, 18 Mar 2007 22:00:00 +0100

The Medical Training Application Service (MTAS)* is fatally flawed and should be suspended until the process has been comprehensively piloted and evaluated, states an Editorial in The Lancet. Moreover, The Department of Health (UK) should use this opportunity to rethink the Modernising Medical Careers (MMC) curriculum. [click link for full article] (Source: Health News from Medical News Today)

[EDITORIALS] Why the UK's Medical Training Application Service failed

BMJ Online First — Wed, 14 Mar 2007 04:00:00 +0100

(Source: BMJ Online First)

Junior Doctors Call For Immediate Inquiry Into Training Chaos, UK

Public Health News From Medical News Today — Mon, 12 Mar 2007 07:00:00 +0100

Junior doctors' leaders have today (Saturday 10 March) voted overwhelmingly for the scrapping of the Government's new system for medical training appointments - known as MTAS and a return to the old appointments system for junior doctors which was in place until earlier this year. [click link for full article] (Source: Public Health News From Medical News Today)

DH Announces Review Of Modernising Medical Careers Applications, UK

Health News from Medical News Today — Mon, 12 Mar 2007 07:00:00 +0100

Following discussion with the medical Royal Colleges and the BMA, theDepartment of Health today announced a review into Round One ofModernising Medical Careers (MMC) recruitment and selection intospecialist training, made through the Medical Training andApplication Service (MTAS). [click link for full article] (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Junior Doctors Call For Immediate Inquiry Into Training Chaos, UK

Health News from Medical News Today — Mon, 12 Mar 2007 07:00:00 +0100

DH Announces Review Of Modernising Medical Careers Applications, UK

Medical Students News From Medical News Today — Mon, 12 Mar 2007 07:00:00 +0100

DH orders review into junior doctor recruitment system

EHI Primary Care — Thu, 08 Mar 2007 17:35:00 +0100

The Department of Health has announced it has ordered a review into the Medical Training and Application Service (MTAS) following claims that the system is 'descending into pandemonium' by the British Medical Association. (Source: EHI Primary Care)

BMA says review of flawed recruitment process welcome but does not go far enough

News-Medical News Feed — Tue, 06 Mar 2007 22:46:00 +0100

Britain's Department of Health has announced a review of the Medical Training Application Service for junior doctors. (Source: News-Medical News Feed)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Junior doctors say training website is in 'pandemonium'

E-Health-Insider — Fri, 02 Mar 2007 11:30:00 +0100

The new web-based Medical Training Application System (MTAS) used to recruit junior doctors has 'descended into pandemonium', according to the British Medical Association. (Source: E-Health-Insider)

Microtubule-targeting agents in angiogenesis: where do we stand?

Drug Resistance Updates — Wed, 01 Feb 2006 05:00:00 +0100

Authors: Pasquier E, Honoré S, Braguer D Angiogenesis is a key event of tumor progression and metastasis and hence a target for cancer chemotherapy. Therapeutic strategies focused on angiogenesis include the discovery of new, targeted anti-angiogenic agents and the re-evaluation of conventional anti-cancer drugs. Here, we review the most recent studies investigating the molecular and cellular mechanisms responsible for the anti-angiogenic activity of microtubule-targeting agents (MTAs). These agents include some of the most widely used and effective antitumor drugs that are also among the most anti-angiogenic. In addition, we summarize the latest results of pre-clinical and clinical studies involving MTAs administered at low metronomic doses and in anti-angiogenic combination strategi...