MedWorm: Texas University

New Procedure Repairs Severed Nerves In Minutes, Restoring Limb Use In Days Or Weeks

Health News from Medical News Today — Tue, 07 Feb 2012 08:00:00 +0100

American scientists believe a new procedure to repair severed nerves could result in patients recovering in days or weeks, rather than months or years. The team used a cellular mechanism similar to that used by many invertebrates to repair damage to nerve axons. Their results are published in the Journal of Neuroscience Research. "We have developed a procedure which can repair severed nerves within minutes so that the behavior they control can be partially restored within days and often largely restored within two to four weeks," said Professor George Bittner from the University of Texas... (Source: Health News from Medical News Today)

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UT MD Anderson, Texas A&M team up to treat canine lymphoma

EurekAlert! - Medicine and Health — Tue, 07 Feb 2012 05:00:00 +0100

(University of Texas M. D. Anderson Cancer Center) A new immunotherapy for companion dogs with advanced-stage non-Hodgkin lymphoma has been shown to improve survival while maintaining quality of life, according to a study published in the journal Scientific Reports. (Source: EurekAlert! - Medicine and Health)

Deterioration of cutaneous microcirculatory status of Kawasaki disease

Clinical Rheumatology — Mon, 06 Feb 2012 19:36:16 +0100

In conclusion, KD patients, both in the afebrile and convalescent phases, exhibited morphologic alterations in the microcirculation when compared to the controls. The results indicate the potential role of dynamic capillaroscopy for the noninvasive survey of microcirculation abnormalities in patients with KD. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s10067-012-1948-xAuthors Ming-Yii Huang, Department of Radiation Oncology, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Tzyou 1st Road, Kaohsiung, 807 TaiwanJoh-Jong Huang, Department of Family Medicine, Yuan’s General Hospital, No. 162 Cheng Kung 1st Road, Kaohsiung, 80249 TaiwanTeh-Yang Huang, Department of Pediatrics, Kaohsiu...

[News of the Week] Newsmakers

Science: Current Issue — Fri, 03 Feb 2012 17:34:11 +0100

This week's Newsmakers are Janet Rowley of the University of Chicago, Brian Druker of the Oregon Health & Science University, Nicholas Lydon of Blueprint Medicines, and Masato Sagawa of Intermetallics Co., winners of the Japan Prizes; Scott Doney, whose nomination to be chief scientist of the National Oceanic and Atmospheric Administration has been withdrawn by the White House; Johannes Vogel, an expert on fern genetics, who took over as director of Berlin's Natural History Museum this week; and Paul Alivisatos of Lawrence Berkeley National Laboratory, Charles Lieber of Harvard University, Jacob Bekenstein of the Hebrew University of Jerusalem, Ronald Evans of the Salk Institute, Michael Aschbacher of the California Institute of Technology, and Luis Caffarelli of the University of Texas, A...

Positive Data Presented on Athersys' MultiStem to Treat Stroke

Medical News (via PRIMEZONE) — Fri, 03 Feb 2012 15:52:00 +0100

CLEVELAND and NEW ORLEANS, Feb. 3, 2012 (GLOBE NEWSWIRE) -- Medical researchers from The University of Texas Health Science Center at Houston (UTHealth) Medical School presented new research results this morning at the American Heart Association International Stroke Conference that highlight the role of the spleen in the mechanisms underlying how MultiStem(r), a novel allogenic stem cell therapy being developed by Athersys, Inc. (Nasdaq:ATHX), reduces damage and enhances functional recovery in animals after an ischemic stroke. (Source: Medical News (via PRIMEZONE))

Alzheimer's-Related Protein In Brains Of Healthy Adults May Shed Light On Earliest Signs Of Disease

Health News from Medical News Today — Fri, 03 Feb 2012 08:00:00 +0100

Researchers from the Center for Vital Longevity at the University of Texas at Dallas and UT Southwestern Medical Center have completed a large-scale neuroimaging study of healthy adults from age 30 to 90 that measured beta-amyloid protein - a substance whose toxic buildup in the brain is a diagnostic marker for Alzheimer's disease. The findings, published in the online issue of Neurology, the medical journal of the American Academy of Neurology, mark a crucial step toward being able to predict who may be at risk for developing Alzheimer's disease long before symptoms appear... (Source: Health News from Medical News Today)

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Conference focuses on vaccines for chronic diseases

EurekAlert! - Social and Behavioral Science — Fri, 03 Feb 2012 05:00:00 +0100

(University of Texas Medical Branch at Galveston) At a symposium sponsored by the University of Texas Medical Branch at Galveston and scheduled for Feb. 7-9, an international group of researchers will discuss development of vaccines for addiction, cancer, chronic infectious diseases and neurodegenerative diseases. (Source: EurekAlert! - Social and Behavioral Science)

UT MD Anderson Article Offers One Roadmap for Defining Value in Health Care, Earns National Award from Leading Journal

M. D. Anderson Cancer Center - News Releases — Fri, 03 Feb 2012 05:00:00 +0100

A team from The University of Texas MD Anderson Cancer Center is receiving a national award for a research article tackling a question vital to the future of health care with reform regulations looming, competition growing and costs rising. (Source: M. D. Anderson Cancer Center - News Releases)

Environmental Audits of Friendliness toward Physical Activity in Three Income Levels

Journal of Urban Health — Thu, 02 Feb 2012 18:15:01 +0100

This study examined the relationships among income levels, features of the environment and friendliness toward physical activity. We investigated whether low-, middle-, and high-income neighborhoods differ in terms of four environmental characteristics that affect the degree to which an area is conducive to physical activity: population density, land use diversity, street design, and physical disorder in the environment. In a large, urban southwestern county, 30 block groups were randomly selected to represent low-, middle-, and high-income neighborhoods. Using the St. Louis Environmental Checklist Audit, walking audits were conducted and analyzed. The low-income neighborhoods had significantly greater density and land use diversity than the high-income neighborhoods. High- and midd...

Should we really fear 'new flesh-eating bacteria'?

NHS News Feed — Thu, 02 Feb 2012 18:15:00 +0100

Conclusion This interesting study helps explain why healthcare-acquired MRSA infections are rarely found in healthy individuals. It found that expression of a gene that produces one of the proteins responsible for MRSA’s antibiotic resistance caused it to be less toxic. It also showed that typical community-acquired MRSA strains express less of this antibiotic-resistance protein, but are more toxic. However, this intriguing lab study did not investigate the transmission, effects or number of cases of community-acquired MRSA in the UK, discussion of which formed the majority of the news reports. On this basis, the research itself does not support the claims that we are under siege from an ‘airborne, bacteria-resistant, flesh-eating superbug’, as newspapers have today suggested. Links...

Attitudes Toward Hepatitis B Virus among Vietnamese, Chinese and Korean Americans in the Houston Area, Texas

Journal of Community Health — Thu, 02 Feb 2012 18:14:01 +0100

Abstract We explored attitudes about prevention, screening and treatment of hepatitis B virus (HBV) infection in Chinese, Korean and Vietnamese communities. We use qualitative methods in 12 focus groups (n = 113) of adults who self-reported their ethnicity to be Chinese, Korean, or Vietnamese. We use grounded theory (i.e., consensus-building between co-coders about recurring, emerging themes) for analysis. Diet, nutrition, fatigue and stress were misidentified as HBV causes. Improving hygiene, diet, exercise, and holistic methods were misidentified as viable HBV prevention methods. Common screening problems included not affording test and not understanding test results. Participants shared reasons for using complementary and alternative medicine—when Western me...

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Perceptions of Social Support, Empowerment and Youth Risk Behaviors

The Journal of Primary Prevention — Thu, 02 Feb 2012 18:09:19 +0100

This study examined the association of perceived social support and community empowerment among urban middle-school students living in Matamoros, Mexico and the risk behaviors of fighting, alcohol and tobacco use, and sexual activity. Middle school students (n = 1,181) from 32 public and private Mexican schools were surveyed. Weighted multiple logistic regression analyses were conducted. Among girls, lack of parent/teacher interactions regarding school increased odds for fighting, alcohol and tobacco use. Among boys, lack of empowerment increased odds of alcohol and tobacco use and lack of parent/teacher interactions regarding school increased odds for sexual activity. Community empowerment and perceived social support are uniquely associated with risk behaviors for girls a...

Untangling the mysteries of Alzheimer's

EurekAlert! - Social and Behavioral Science — Thu, 02 Feb 2012 05:00:00 +0100

(University of Texas Medical Branch at Galveston) Researchers have found new evidence that confirms the significance of a protein that neuroscientists call tau to the development of Alzheimer's disease. While earlier studies have focused on tau's aggregation into twisted structures known as "neurofibrillary tangles," the new work emphasizes intermediary steps between single protein units and the much larger tangles - small assemblages of two, three, four or more proteins, which the investigators believe are the most toxic entities in Alzheimer's. (Source: EurekAlert! - Social and Behavioral Science)

De novo acute myeloid leukemia risk factors

Cancer — Wed, 01 Feb 2012 05:00:00 +0100

CONCLUSIONS:The current results suggested that several factors play a role in AML predisposition with possible joint effects. Risk profiles for AML differed by sex and WHO subtype. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer)

Strategic patient education program to prevent catheter-related bloodstream infection.

Clinical Journal of Oncology Nursing — Wed, 01 Feb 2012 05:00:00 +0100

This article presents the history and roles of the Infusion Therapy Team at the University of Texas MD Anderson Cancer Center in CVC care and describes an organized patient education program that plays a key part in the institution's strategy to reduce and prevent CRBSI. Institutional standard policies and procedures for patient care should be in compliance with guidelines of the Centers for Disease Control and Prevention and the Joint Commission before any patient educational initiative is implemented. Such standards will serve as a guide to set up, organize, and implement an effective program. PMID: 22297016 [PubMed - in process] (Source: Clinical Journal of Oncology Nursing)

Superiority of the buffy coat over serum or plasma for the detection of Alkhumra virus RNA using real time RT-PCR

Archives of Virology — Tue, 31 Jan 2012 16:44:28 +0100

In this study, RT-PCR detection of viral RNA from the plasma, serum, and buffy coat (BC) was compared to virus isolation. Plasma, serum, and BC were obtained from seven patients with clinically suspected ALKV infection in Najran, Saudi Arabia. Baby hamster kidney (BHK-21) and rhesus monkey kidney (LLC-MK2) cell culture monolayers were used for virus isolation. Real-time RT-PCR was used to confirm ALKV infection and to detect viral RNA directly from plasma, serum, and BC. ALKV was isolated from five of the seven patients. The virus was isolated from all three specimen types (plasma, serum, and BC) of the five confirmed patients. ALKV RNA was detected directly by RT-PCR in BC in all five (100%) culture-positive patients and in plasma or serum in only four (80%) of the five patients. Th...

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Major Challenge Of Drug Delivery Addressed By Researchers' Innovation

Health News from Medical News Today — Tue, 31 Jan 2012 08:00:00 +0100

A new physical form of proteins developed by researchers at The University of Texas at Austin could drastically improve treatments for cancer and other diseases, as well as overcome some of the largest challenges in therapeutics: delivering drugs to patients safely, easily and more effectively... (Source: Health News from Medical News Today)

SUMO-Snipping Protein Plays Crucial Role In T And B Cell Development

Health News from Medical News Today — Tue, 31 Jan 2012 08:00:00 +0100

When SUMO grips STAT5, a protein that activates genes, it blocks the healthy embryonic development of immune B cells and T cells unless its nemesis breaks the hold, a research team led by scientists at The University of Texas MD Anderson Cancer Center reports in Molecular Cell. "This research extends the activity of SUMO and the Sentrin/SUMO-specific protease 1 (SENP1) to the field of immunology, in particular the early lymphoid development of T and B cells," said the study's senior author, Edward T. H. Yeh, M.D., professor and chair of MD Anderson's Department of Cardiology... (Source: Health News from Medical News Today)

Incidence of unanticipated difficult airway in obstetric patients in a teaching institution

Journal of Anesthesia — Mon, 30 Jan 2012 16:07:54 +0100

Conclusion Unanticipated difficult airways accounted for 0.56% of all pregnancy-related surgical patients. More than 99.9% of all obstetric patients could be intubated. A difficult airway is more likely to be encountered by anesthesia providers with <1 year of experience. Proper use of airway equipment may help secure the obstetric airway or provide adequate ventilation. Emergency CD did not add an additional level of difficulty over nonemergency CD. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00540-012-1338-1Authors Weike Tao, Department of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9068, USAJason T. Edwards, Department of Anesthes...

Lessons from ALL-REZ BFM 90: Therapy for Childhood Leukemia Based on Timing and Site of Relapse

Current Hematologic Malignancy Reports — Mon, 30 Jan 2012 16:04:36 +0100

Content Type Journal ArticleCategory Invited CommentaryPages 1-2DOI 10.1007/s11899-011-0112-zAuthors Michael E. Rytting, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA Journal Current Hematologic Malignancy ReportsOnline ISSN 1558-822XPrint ISSN 1558-8211 (Source: Current Hematologic Malignancy Reports)

How Bad Are We At Forecasting Our Emotions

Health News from Medical News Today — Mon, 30 Jan 2012 08:00:00 +0100

How will you feel if you fail that test? Awful, really awful, you say. Then you fail the test and, yes, you feel bad - but not as bad as you thought you would. This pattern holds for most people, research shows. The takeaway message: People are lousy at predicting their emotions. "Psychology has focused on how we mess up and how stupid we are," says University of Texas Austin psychologist Samuel D. Gosling. But Gosling and colleague Michael Tyler Mathieu suspected that researchers were missing part of the story... (Source: Health News from Medical News Today)

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SUMO-Snipping Protein Plays Crucial Role in T and B Cell Development

M. D. Anderson Cancer Center - News Releases — Mon, 30 Jan 2012 05:00:00 +0100

Pleiotropic Effects of Statins: The Role of Eicosanoid Production

Current Atherosclerosis Reports — Sat, 28 Jan 2012 16:50:51 +0100

Abstract The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have potent anti-inflammatory, vasodilatory and anti-platelet effects that are independent of the lipid-lowering effects. These non–lipid-lowering or pleiotropic effects are dependent on HMG-CoA reductase inhibition in tissues other than the liver. In animal models, high-dose statins upregulate cytosolic phospholipase A2 and cyclooxygenase-2, leading to increased production of prostacyclin and 15-deoxy-PGJ2. In addition, statins activate protein kinase A, which phosphorylates 5-lipoxygenase, resulting in decreased production of the pro-inflammatory leukotrienes and increased production of 15-epi-lipoxin A4, an eicosanoid with potent anti-inflammatory and inflammation-resolution pro...

Mutated Kras Spins A Molecular Loop That Launches Pancreatic Cancer

Health News from Medical News Today — Sat, 28 Jan 2012 08:00:00 +0100

Scientists have connected two signature characteristics of pancreatic cancer, identifying a self-perpetuating "vicious cycle" of molecular activity and a new potential target for drugs to treat one of the most lethal forms of cancer. The research, reported in the journal Cancer Cell and led by scientists at The University of Texas MD Anderson Cancer Center, connected the molecular dots between: Mutated versions of Kras, a gene that acts as a molecular on-off switch but gets stuck in the "on" position when mutated... (Source: Health News from Medical News Today)

Students Report Playing Dangerous ‘Choking Game’

The Doctors Lounge - Health News — Fri, 27 Jan 2012 22:00:00 +0100

One in seven at a Texas university tried it, survey finds (Source: The Doctors Lounge - Health News)

Students Report Playing Dangerous 'Choking Game'

MedlinePlus Health News — Fri, 27 Jan 2012 21:00:00 +0100

One in seven at a Texas university tried it, survey finds Source: HealthDay Related MedlinePlus Page: College Health (Source: MedlinePlus Health News)

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Genetic Mutation That Triggers Pancreatic Cancer Identified

Health News from Medical News Today — Fri, 27 Jan 2012 18:00:00 +0100

Scientists at The University of Texas MD Anderson Cancer Center have identified a self-perpetuating "loop" of molecular activity that fuels pancreatic cancer by linking two signature characteristics of the disease - Kras, a gene that serves as a molecular on-off switch, but gets stuck on the "on" position when mutated, and NF-ÎºB, a protein complex that controls activation of genes. In addition, the team identified a new potential drug target to block this process... (Source: Health News from Medical News Today)

SUMO-snipping protein plays crucial role in T and B cell development

EurekAlert! - Medicine and Health — Fri, 27 Jan 2012 05:00:00 +0100

(University of Texas M. D. Anderson Cancer Center) When SUMO grips STAT5, a protein that activates genes, it blocks the healthy embryonic development of immune B cells and T cells unless its nemesis breaks the hold, a research team led by scientists at the University of Texas MD Anderson Cancer Center reports today in Molecular Cell. (Source: EurekAlert! - Medicine and Health)

Are we bad at forecasting our emotions? It depends on how you measure accuracy

EurekAlert! - Social and Behavioral Science — Fri, 27 Jan 2012 05:00:00 +0100

(Association for Psychological Science) How will you feel if you fail that test? Awful, really awful, you say. Then you fail the test and, yes, you feel bad -- but not as bad as you thought you would. This pattern holds for most people, research shows. The takeaway message: People are lousy at predicting their emotions. "Psychology has focused on how we mess up and how stupid we are," says University of Texas Austin psychologist Samuel D. Gosling. (Source: EurekAlert! - Social and Behavioral Science)

UT researchers' innovation addresses major challenge of drug delivery

EurekAlert! - Medicine and Health — Fri, 27 Jan 2012 05:00:00 +0100

(University of Texas at Austin) A new physical form of proteins developed by researchers at the University of Texas at Austin could drastically improve treatments for cancer and other diseases, as well as overcome some of the largest challenges in therapeutics: Delivering drugs to patients safely, easily and more effectively. (Source: EurekAlert! - Medicine and Health)

Preoperative Serum Osteocalcin may Predict Postoperative Elevated Parathyroid Hormone in Patients with Primary Hyperparathyroidism

World Journal of Surgery — Thu, 26 Jan 2012 06:56:55 +0100

Conclusions Preoperative OC may help to predict risk of POePTH in patients with PHPT. Research with longer follow-up in patients with no known baseline chronic kidney disease stratified by high versus normal preoperative serum creatinine is recommended. Content Type Journal ArticlePages 1-7DOI 10.1007/s00268-012-1432-4Authors Nahid Rianon, Department of Family and Community Medicine, University of Texas Medical School at Houston, 6431 Fannin Street #JJL324, Houston, TX 77030, USAGillian Alex, University of Texas Medical School at Houston, 6431 Fannin St. #G-400 MSB, Houston, TX 77030, USAGlenda Callender, Department of Surgery, University of Louisville, 315 E. Broadway, Suite 312, Louisville, KY 40202, USACamilo Jimenez, Department of Endocrine Neoplasia, MD Anderson...

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Mutated Kras spins a molecular loop that launches pancreatic cancer

EurekAlert! - Medicine and Health — Thu, 26 Jan 2012 05:00:00 +0100

(University of Texas M. D. Anderson Cancer Center) Scientists have connected two signature characteristics of pancreatic cancer, identifying a self-perpetuating "vicious cycle" of molecular activity and a new potential target for drugs to treat one of the most lethal forms of cancer. (Source: EurekAlert! - Medicine and Health)

Researchers hide 3D object with "plasmonic cloak"

Physics Today News Picks — Thu, 26 Jan 2012 05:00:00 +0100

Daily Mail: Researchers at the University of Texas at Austin have succeeded in cloaking a three-dimensional object. According to their results published today in the New Journal of Physics, the group used plasmonic metamaterials to hide an 18-cm cylindrical tube illuminated by microwave radiation. Plasmonic metamaterials scatter light rays differently from the way more common materials do. "When the scattered fields from the cloak and the object interfere, they cancel each other out and the overall effect is transparency and invisibility at all angles of observation," said Andrea Alù, one of the study’s coauthors. One of the next challenges will be to demonstrate cloaking in visible light. (Source: Physics Today News Picks)

Acculturation, depressive symptoms, estriol, progesterone, and preterm birth in Hispanic women

Archives of Women's Mental Health — Wed, 25 Jan 2012 18:13:11 +0100

We examined the effects of acculturation, depressive symptoms, progesterone, and estriol (E3) as predictors of preterm birth (PTB) in pregnant Hispanic women. This cross-sectional study recruited a sample of 470 Hispanic women between 22- and 24-week gestation from physician practices and community clinics. We used the CES-D to measure maternal depressive symptoms. We measured acculturation by English proficiency on the Bidimensional Acculturation Scale, residence index by years in the USA minus age, nativity, and generational status. Serum progesterone and E3 were analyzed by EIA. Ultrasound and medical records determined gestational age after delivery. In χ 2 analysis, there were a significantly greater percentage of women with higher depressive scores if they were born in the USA...

Comparison of two dosing schedules of palonosetron for the prevention of nausea and vomiting due to interleukin-2-based biochemotherapy

Supportive Care in Cancer — Wed, 25 Jan 2012 06:52:50 +0100

Conclusions Both dosing schedules of palonosetron were tolerated well. Alternate day dosing of palonosetron was more effective in controlling CINV in this patient population. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00520-011-1359-6Authors Rahat Noor, Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 430, Houston, TX 77030, USAAgop Y. Bedikian, Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 430, Houston, TX 77030, USASandy Mahoney, Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 430, Houston, TX 77030, USARoland Bassett, Department...

Research shows genes influence criminal behavior

EurekAlert! - Social and Behavioral Science — Wed, 25 Jan 2012 05:00:00 +0100

(University of Texas at Dallas) University of Texas at Dallas criminologist Dr. J.C. Barnes has researched connections between genes and an individual's propensity for crime. (Source: EurekAlert! - Social and Behavioral Science)

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Quality Of Life Issues For Patients With Chronic Myeloid Leukemia

Health News from Medical News Today — Tue, 24 Jan 2012 09:00:00 +0100

Although significant progress has been made in treating chronic myeloid leukemia, the disease cannot yet be eliminated in all patients, and that challenge must be addressed, states a commentary in CMAJ (Canadian Medical Association Journal).). Likening the journey to find a cure for chronic myeloid leukemia as a marathon, cancer expert Dr. Jorge Cortes, University of Texas, MD Anderson Cancer Center, Houston, Texas, writes, "The past half century has been an extraordinary run that has us on an excellent pace to not only complete the race to a cure, but to do so in record time... (Source: Health News from Medical News Today)

How Salt, Potassium Levels Are Moderated Revealed By Study Of Rare Kidney Disease

Health News from Medical News Today — Tue, 24 Jan 2012 09:00:00 +0100

High blood pressure (hypertension) is a principal risk factor for heart disease and affects 1 billion people. At least half of them are estimated to be salt-sensitive; their blood pressure rises with sodium intake. New research shows important aspects of how sodium and potassium are regulated in the kidney. The work, posted online by Nature, also offers insight on how one form of familial high blood pressure disease is inherited. Nephrology researchers in the School of Medicine at The University of Texas Health Science Center San Antonio are co-authors... (Source: Health News from Medical News Today)

Assessing the added value of breast tumor markers in genetic risk prediction model BRCAPRO

Breast Cancer Research and Treatment — Tue, 24 Jan 2012 07:35:04 +0100

Abstract The BRCAPRO model estimates carrier probabilities for the BRCA1 and BRCA2 genes, and was recently enhanced to use estrogen receptor (ER) and progesterone receptor (PR) status of breast cancer. No independent assessment of the added value of these markers exists. Moreover, earlier versions of BRCAPRO did not use human epidermal growth factor receptor 2 (Her-2/neu) status of breast cancer. Here, we incorporate Her-2/neu in BRCAPRO and validate all the markers. We trained the enhanced model on 406 germline tested individuals, and validated on a separate clinical cohort of 796 individuals for whom test results and family history are available. For model-building, we estimated joint probabilities of ER, PR, and Her-2/neu status for carriers and non-carriers of BRCA1/2...

The Fast Food and Obesity Link: Consumption Patterns and Severity of Obesity

Obesity Surgery — Tue, 24 Jan 2012 06:50:10 +0100

Conclusions Our findings suggest that higher rates of fast food consumption are connected to the increasing rates of severe obesity. Given that morbid and super morbid obesity rates are growing at a more advanced pace than moderate obesity, it is necessary to explore the behavioral characteristics associated with these trends. Content Type Journal ArticleCategory Basic Science ResearchPages 1-9DOI 10.1007/s11695-012-0601-8Authors Ginny Garcia, Department of Sociology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-0655, USAThankam S. Sunil, Department of Sociology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-0655, USAPedro Hinojosa, Department of Sociology, University of Texas at San Antonio, One UTSA Circle...

α2- and β-adrenoceptors involvement in nortriptyline modulation of auditory sustained attention and impulsivity

Psychopharmacology — Tue, 24 Jan 2012 06:49:38 +0100

Conclusions We conclude that sustained attention displays an inverse U-shaped dependence on NT, mediated—at least in part—by α2- and β-adrenoceptors. We speculate that low doses of NT improve performance by maximizing the phasic release of NE, while higher doses of NT would elevate tonic levels of NE, thus producing suboptimal levels of phasically released NE. Content Type Journal ArticleCategory Original InvestigationPages 1-9DOI 10.1007/s00213-012-2635-yAuthors Swagata Roychowdhury, Laboratory of Synaptic and Cellular Physiology, School of Behavioral and Brain Sciences, University of Texas at Dallas/GR41, 800 West Campbell Road, Richardson, TX 75080, USAZulma Peña-Contreras, Laboratory of Synaptic and Cellular Physiology, School of Behavioral and Brain Scien...

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By Stifling Protective Genes, Inflammatory Mediator Promotes Colorectal Cancer

Health News from Medical News Today — Mon, 23 Jan 2012 08:00:00 +0100

Chronic inflammation combines with DNA methylation, a process that shuts down cancer-fighting genes, to promote development of colorectal cancer, scientists at The University of Texas MD Anderson Cancer Center report today in the advance online publication of the journal Nature Medicine. The team's connection of these two separate influences eventually may lead to better combination therapies for treating and preventing colorectal cancer... (Source: Health News from Medical News Today)

Inflammatory Mediator Promotes Colorectal Cancer by Stifling Protective Genes

M. D. Anderson Cancer Center - News Releases — Mon, 23 Jan 2012 05:00:00 +0100

Chronic inflammation combines with DNA methylation, a process that shuts down cancer-fighting genes, to promote development of colorectal cancer, scientists at The University of Texas MD Anderson Cancer Center report today in the advance online publication of the journal Nature Medicine. (Source: M. D. Anderson Cancer Center - News Releases)

Inflammatory mediator promotes colorectal cancer by stifling protective genes

EurekAlert! - Medicine and Health — Sun, 22 Jan 2012 05:00:00 +0100

(University of Texas M. D. Anderson Cancer Center) Chronic inflammation combines with DNA methylation, a process that shuts down cancer-fighting genes, to promote development of colorectal cancer, scientists at The University of Texas MD Anderson Cancer Center report today in the advance online publication of the journal Nature Medicine. (Source: EurekAlert! - Medicine and Health)

Rare kidney disease shows how salt, potassium levels are moderated

EurekAlert! - Medicine and Health — Sun, 22 Jan 2012 05:00:00 +0100

(University of Texas Health Science Center at San Antonio) Findings in Nature about one form of familial high blood pressure disease offer insights into how sodium and potassium are regulated in the kidney. (Source: EurekAlert! - Medicine and Health)

Alarming Number Of Texas Teens Playing The Choking Game

Health News from Medical News Today — Fri, 20 Jan 2012 09:00:00 +0100

Nearly one out of seven college students surveyed at a Texas university has participated in the Choking Game, a dangerous behavior where blood flow is deliberately cut off to the brain in order to achieve a high, according to a study by The Crime Victims' Institute at Sam Houston State University... (Source: Health News from Medical News Today)

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Ethnic Differences in the Home Food Environment and Parental Food Practices Among Families of Low-Income Hispanic and African-American Preschoolers

Journal of Immigrant and Minority Health — Fri, 20 Jan 2012 07:46:49 +0100

We examined ethnic differences in the home food environment and parental practices among 706 low-income, African-American and Hispanic families of preschoolers. Questionnaires measured the access and availability of various foods in the home, parental practices, and meal consumption behaviors. Mixed model logistic regression and ANCOVA were used to assess ethnic differences. Unhealthy foods were available for both groups. Hispanic families were more likely to have fresh vegetables (AOR = 2.9, P ≤ 0.001), fruit (AOR = 2.0, P = 0.004), and soda available (AOR = 1.40, P = 0.001) compared to African-Americans. African-Americans families were more likely to restrict (AOR = 0.63, P ≤ 0.001) and reward with de...

MD Anderson Brings Free Making Cancer History Seminar® to West Palm Beach

M. D. Anderson Cancer Center - News Releases — Fri, 20 Jan 2012 05:00:00 +0100

Cancer experts from The University of Texas MD Anderson Cancer Center return to West Palm Beach Feb. 11 for the institution's annual Making Cancer History® seminar. The event, in the Cohen Pavilion of the Raymond F. Kravis Center for the Performing Arts, 701 Okeechobee Blvd., begins at 8:30 a.m. with a breakfast buffet. (Source: M. D. Anderson Cancer Center - News Releases)

Minor salivary gland malignancies in the pediatric population

Head and Neck — Fri, 20 Jan 2012 05:00:00 +0100

ConclusionMinor salivary gland malignancies in children are rare. Surgical resection with clear margins yields excellent outcomes in patients with low‐intermediate grade and early stage tumors. Patients with high‐grade malignancies do poorly despite multimodality therapy. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)

Defined Clinical Classifications Are Associated with Outcome of Patients with Anatomically Resectable Pancreatic Adenocarcinoma Treated with Neoadjuvant Therapy

Annals of Surgical Oncology — Thu, 19 Jan 2012 07:00:34 +0100

Conclusions This system describes discrete clinical subgroups of patients with pancreatic cancer who have similar, potentially resectable tumor anatomy but heterogeneous physiology and cancer biology. It may be used with neoadjuvant therapy to predict outcomes, individualize treatment algorithms, and optimize survival. Content Type Journal ArticleCategory Pancreatic TumorsPages 1-9DOI 10.1245/s10434-011-2211-4Authors Ching-Wei D. Tzeng, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAJason B. Fleming, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAJeffrey E. Lee, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAL...

Outcomes of obese versus non-obese subjects undergoing robotic-assisted hysterectomy: a multi-institutional study

Journal of Robotic Surgery — Thu, 19 Jan 2012 06:59:21 +0100

Abstract The goal of our study was to determine whether there was a difference in operative outcomes in obese versus non-obese subjects undergoing robotic-assisted hysterectomies of varying levels of difficulty. Secondarily, we sought to analyze the published outcomes between robotic-assisted hysterectomy and total laparoscopic hysterectomy in obese women at each of these levels of difficulty. This was a multi-institutional retrospective cohort study of all patients undergoing robotic-assisted hysterectomy by five gynecologic oncologists at four geographically separate locations from April 2003 to March 2008. The cohort was stratified into obese vs. non-obese groups, and defined surgical outcomes compared between groups, then further divided into three subgroups based on c...

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Ethnic/Racial Disparities in the Fetal Growth Outcomes of Ecuadorian Newborns

Journal of Immigrant and Minority Health — Thu, 19 Jan 2012 06:55:25 +0100

Abstract Size at birth is an important indicator of future infant morbidity and mortality. Ethnic/racial disparities in birth weight and other fetal growth outcomes are well documented for US and Canadian minority groups but not for those in Latin America. The study compared the growth outcomes of 1,227 full-term Ecuadorian newborns delivered by Afro-descendant and indigenous minority women with those of ethnic majority (mestizo) women. Minority newborns had higher risk for congenital microcephaly but no excess risk for low birth weight or stunted linear growth compared to mestizos. However, minority newborns were significantly heavier at birth, weighing an average of 3–5% more than mestizos. Afro-Ecuadorians newborns also were fatter. The risk profile of Ecuadorian ethn...

The Placebo Phenomenon: Implications for the Ethics of Shared Decision-Making

Journal of General Internal Medicine — Thu, 19 Jan 2012 06:51:10 +0100

Abstract Recent research into the placebo effect has implications for the ethics of shared decision-making (SDM). The older biomedical model views SDM as affecting which therapy is chosen, but not the nature or likelihood of any health outcomes produced by the therapy. Research indicates, however, that both the content and manner in which information is shared with the patient, and the patient’s experience of being involved in the decision, can directly alter therapeutic outcomes via placebo responses. An ethical tension is thereby created between SDM aimed strictly and solely at conveying accurate information, and “outcome engineering” in which SDM is adapted toward therapeutic goals. Several practical strategies mitigate this tension and promote respect for autonom...

Choking game prevalent on Texas campus

Health News - UPI.com — Thu, 19 Jan 2012 01:13:17 +0100

HUNTSVILLE, Texas, Jan. 18 (UPI) -- Most students at a Texas university say they played the Choking Game in which blood flow is deliberately cut off to the brain to get high, researchers say. (Source: Health News - UPI.com)

Choking Game played at Texas campus

Health News - UPI.com — Thu, 19 Jan 2012 01:13:17 +0100

HUNTSVILLE, Texas, Jan. 18 (UPI) -- Sixteen percent of students at a Texas university say they played the Choking Game -- blood flow is cut off to the brain to get high, researchers say. (Source: Health News - UPI.com)

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Educational disadvantages associated with race still persist in Brazil despite improvements

EurekAlert! - Social and Behavioral Science — Wed, 18 Jan 2012 05:00:00 +0100

(University of Texas at Austin) Despite notable improvements in educational levels and opportunity during the past three decades, disadvantages associated with race still persist in Brazil, according to new research at the University of Texas at Austin. (Source: EurekAlert! - Social and Behavioral Science)

Mapping the destructive path from cigarette to emphysema

EurekAlert! - Biology — Wed, 18 Jan 2012 05:00:00 +0100

(Baylor College of Medicine) In a report online in the journal Science Translational Medicine, the scientists, including two from the University of Texas MD Anderson Cancer Center, described the track the toxic smoke takes through the tissues and how they accomplish their destructive work. (Source: EurekAlert! - Biology)

Choking game prevalent among teens in Texas

EurekAlert! - Social and Behavioral Science — Wed, 18 Jan 2012 05:00:00 +0100

(Sam Houston State University) Nearly one out of seven college students surveyed at a Texas university has participated in the Choking Game, a dangerous behavior where blood flow is deliberately cut off to the brain in order to achieve a high, according to a study by The Crime Victims' Institute at Sam Houston State University. (Source: EurekAlert! - Social and Behavioral Science)

Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway

Journal of Neuro-Oncology — Tue, 17 Jan 2012 07:19:32 +0100

Abstract Glioma stem-like cells (GSCs) may be the initiating cells in glioblastoma (GBM) and contribute to the resistance of these tumors to conventional therapies. Development of novel chemotherapeutic agents and treatment approaches against GBM, especially those specifically targeting GSCs are thus necessary. In the present study, we found that a novel Janus kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) pathway inhibitor (WP1193) significantly decreased the proliferation of established glioma cell lines in vitro and inhibit the growth of glioma in vivo. To test the efficacy of WP1193 against GSCs, we then administrated WP1193 to GSCs isolated and expanded from multiple human GBM tumors. We revealed that WP1193 suppressed phosphorylation of JAK2...

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Prevalence of HIV Risk Behaviors among Undocumented Central American Immigrant Women in Houston, Texas

AIDS and Behavior — Tue, 17 Jan 2012 07:17:37 +0100

Abstract Undocumented Central American immigrants in the United States are disproportionately affected by HIV infection. However, epidemiological data on sexual behaviors among undocumented women are sparse and the extent to which behaviors vary by duration of residence in the U.S.is largely unknown. In 2010, we used respondent driven sampling to conduct an HIV behavioral survey among Central American immigrant women residing in Houston, Texas without a valid U.S. visa or residency papers. Here we describe the prevalence of sexual risk behaviors and compare recent (5 years or less in the U.S.) and established immigrants (over 5 years in the U.S.) to elucidate changes in sexual risk behaviors over time. Our data suggest that recent immigrants have less stable sexua...

Long-term physical activity outcomes of home-based lifestyle interventions among breast and prostate cancer survivors

Supportive Care in Cancer — Tue, 17 Jan 2012 07:12:56 +0100

Conclusions This study provides evidence that mailed-print exercise interventions result in significant and sustainable improvements in MVPA among newly diagnosed cancer survivors that are observed well after the intervention is complete. While tailored interventions, as compared to standardized materials, appear to produce superior improvements in MVPA initially, these differences diminish over time. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00520-011-1370-yAuthors Allison J. Ottenbacher, University of Texas - Memorial Hermann, Center for Healthcare Quality and Safety, Houston, TX, USAR. Sue Day, University of Texas School of Public Health, Houston, TX, USAWendell C. Taylor, University of Texas School of Public Health, Houston, TX,...

Functional Outcomes after Chemoradiotherapy of Laryngeal and Pharyngeal Cancers

Current Oncology Reports — Tue, 17 Jan 2012 07:10:27 +0100

Abstract Organ preservation regimens that combine chemotherapy and radiotherapy (chemoradiotherapy) are increasingly used as the primary treatment of laryngeal and pharyngeal cancers. Meta-analytic data show a survival benefit with combined modality therapy, but the functional sequelae can be significant. Dysphagia is recognized as a common and often devastating late effect of chemoradiotherapy. This review examines functional outcomes after chemoradiotherapy for laryngeal and pharyngeal cancers, with a particular emphasis on dysphagia. Topics examined include the burden of dysphagia after chemoradiation, pathophysiology of dysphagia, baseline functioning, recommendations to improve long-term function, and voice outcomes. Content Type Journal ArticleCategory Head and N...

Epigenetic regulation of genomic integrity

Chromosoma — Tue, 17 Jan 2012 07:09:59 +0100

Abstract Inefficient and inaccurate repair of DNA damage is the principal cause of DNA mutations, chromosomal aberrations, and carcinogenesis. Numerous multiple-step DNA repair pathways exist whose deployment depends on the nature of the DNA lesion. Common to all eukaryotic DNA repair pathways is the need to unravel the compacted chromatin structure to facilitate access of the repair machinery to the DNA and restoration of the original chromatin state afterward. Accordingly, our cells utilize a plethora of coordinated mechanisms to locally open up the chromatin structure to reveal the underlying DNA sequence and to orchestrate the efficient and accurate repair of DNA lesions. Here we review changes to the chromatin structure that are intrinsic to the DNA damage response an...

Predicting survival of patients with hypocellular myelodysplastic syndrome

Cancer — Tue, 17 Jan 2012 05:00:00 +0100

CONCLUSIONS:A new prognostic model based on these factors was built that segregated patients into 3 distinct risk categories independent of International Prognostic Scoring System (IPSS) score. This model is independent from the IPSS, further refines IPSS‐based prognostication, and may be used to develop of risk‐adapted therapeutic approaches for patients with hypocellular MDS. Cancer 2012. © 2012 American Cancer Society. (Source: Cancer)

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Quality of laparoscopic radical hysterectomy in developing countries: A comparison of surgical and oncologic outcomes between a comprehensive cancer center in the United States and a cancer center in Colombia.

Gynecologic Oncology — Mon, 16 Jan 2012 05:00:00 +0100

CONCLUSIONS: Surgical and oncologic outcomes of laparoscopic radical hysterectomy were not worse at a cancer center in a developing country than at a large comprehensive cancer center in the United States. These results support consideration of developing countries for inclusion in collaborations for prospective surgical studies. PMID: 22261300 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Stem Cell Implants Help Heal Traumatic Brain Injury In The Lab

Health News from Medical News Today — Sun, 15 Jan 2012 08:00:00 +0100

For years, researchers seeking new therapies for traumatic brain injury have been tantalized by the results of animal experiments with stem cells. In numerous studies, stem cell implantation has substantially improved brain function in experimental animals with brain trauma. But just how these improvements occur has remained a mystery. Now, an important part of this puzzle has been pieced together by researchers at the University of Texas Medical Branch at Galveston... (Source: Health News from Medical News Today)

Autofocus and the importance of 'defocusing'

Guardian Unlimited Science — Sun, 15 Jan 2012 00:01:03 +0100

The human eye's ability to focus is a complex function even advanced cameras struggle to replicate. Not for much longer…We take it for granted, but the human ability to focus instantly on particular objects in our field of vision, near or far, is a remarkable skill. As camera manufacturers have learned, it is not easy to replicate artificially. Even the most advanced digital cameras use autofocus mechanisms that are far from perfect. But now two US scientists have developed a simple algorithm that looks set to revolutionise the way autofocus works, allowing for greater speed and accuracy in digital photography.The development emerged from a study of the human eye. Johannes Burge, a postdoctoral researcher at the University of Texas and his adviser Wilson Geisler wanted to understand how ...

Racial disparities in treatment for pancreatic cancer and impact on survival: a population-based analysis

Journal of Cancer Research and Clinical Oncology — Sat, 14 Jan 2012 16:42:32 +0100

Conclusion Blacks have worst survival from locoregional pancreatic cancer. Receiving treatment for pancreatic cancer only explains 25% of the poorer survival amongst blacks, suggesting role of other factors. Studies are suggested to (a) identify barriers in receipt of treatment for pancreatic cancer amongst blacks and (b) to assess role of genetic and other factors to examine racial differences in survival. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-012-1156-8Authors Vinamrata Singal, Departments of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USAAshwani K. Singal, Department of Gastroenterology-Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905-0001, USAYong-Fang Kuo, Department of...

Salivary Gland Cancers: Biology and Molecular Targets for Therapy

Current Oncology Reports — Fri, 13 Jan 2012 17:15:38 +0100

Abstract Salivary gland carcinomas are a heterogeneous group of tumors with different biologic behavior. Given the lack of large randomized studies, there is no standard treatment for advanced and/or metastatic salivary gland tumors, and systemic therapy is empirically based. Tumor-specific recurrent chromosomal translocations and fusion oncogenes in aggressive head and neck malignancies have diagnostic, therapeutic, and prognostic implications. Pathognomonic fusion transcripts have been identified in subsets of mucoepidermoid carcinoma and adenoid cystic carcinoma. These translocations target 1) transcription factors involved in growth factor signaling and cell cycle regulation, 2) transcriptional co-activators, and 3) tyrosine kinase receptors. Prioritizing studies with ...

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Accumulation of Pro-Cancer Cytokines in the Plasma Fraction of Stored Packed Red Cells

Journal of Gastrointestinal Surgery — Fri, 13 Jan 2012 16:56:38 +0100

Conclusion Pro-cancer cytokines that can augment tumor progression were identified in pRBCs. Some of these factors are present in fresh blood. The soluble factors identified herein may represent possible therapeutic targets to offset negative effects of transfusion. These data stress the need for efforts in cancer patients to reduce transfusion requirements if needed. Content Type Journal ArticleCategory 2011 SSAT Plenary PresentationPages 1-9DOI 10.1007/s11605-011-1798-xAuthors Douglas D. Benson, Denver Health Medical Center, 777 Bannock St., Denver, CO 80204-0206, USAAdam W. Beck, University of Texas-Southwestern Medical Center, Dallas, TX, USAMarie S. Burdine, University of Texas-Southwestern Medical Center, Dallas, TX, USARolf Brekken, University of Texas-Southw...

Young Women Often Fail To Spot Their Weight Gain

Health News from Medical News Today — Thu, 12 Jan 2012 09:00:00 +0100

Despite popular belief about women's weight concerns, young women commonly fail to recognize recent gain of as many as 11 pounds - putting them at risk for cardiovascular disease and other obesity-related conditions. Self-perception of weight gain also appears to be significantly influenced by race, ethnicity and contraceptive methods. In a study published online and in the March issue of the Journal of Women's Health, University of Texas Medical Branch (UTMB) researchers found that a significant number of women evaluated at six-month intervals did not recognize recent gains in weight... (Source: Health News from Medical News Today)

Sulfonylurea receptor as a target for molecular imaging of pancreas beta cells with 99mTc-DTPA-glipizide

Annals of Nuclear Medicine — Thu, 12 Jan 2012 06:43:09 +0100

Conclusions It is feasible to use 99mTc-DTPA-GLP to assess pancreas beta cell receptor recognition. 99mTc-DTPA-GLP may be helpful in evaluating patients with diabetes, pancreatitis and pancreatic tumors. Content Type Journal ArticleCategory Original articlePages 1-9DOI 10.1007/s12149-011-0569-9Authors Chang-Sok Oh, Division of Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 59, Houston, TX 77030, USASaady Kohanim, Division of Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 59, Houston, TX 77030, USAFan-Lin Kong, Division of Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 59, Houston, TX 77030, USAHo-Chun Song, Departm...

Scientists learn how stem cell implants help heal traumatic brain injury

EurekAlert! - Medicine and Health — Thu, 12 Jan 2012 05:00:00 +0100

(University of Texas Medical Branch at Galveston) Researchers have identified key molecular mechanisms by which implanted human neural stem cells aid recovery from traumatic axonal injury. (Source: EurekAlert! - Medicine and Health)

Chemoprevention of prostate cancer: an updated view

World Journal of Urology — Wed, 11 Jan 2012 17:52:25 +0100

Conclusions Primary prevention of prostate cancer remains an attractive goal because of its prevalence and treatment-related morbidity. Neither selenium nor vitamin E prevents prostate cancer. The benefit/risk ratio for 5α-reductase inhibitors can be improved by limiting their use to men at high risk. Content Type Journal ArticleCategory Topic PaperPages 1-6DOI 10.1007/s00345-011-0822-9Authors Eric A. Klein, Glickman Urological and Kidney Institute, Desk Q10-1, 9500 Euclid Ave, Cleveland, OH 44122, USAIan M. Thompson, Cancer Treatment and Research Center, University of Texas Health Science Center, 7979 Wurzbach Rd., San Antonio, TX 78229, USA Journal World Journal of UrologyOnline ISSN 1433-8726Print ISSN 0724-4983 (Source: World Journal of Urology)

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Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties

Journal of Cancer Research and Clinical Oncology — Wed, 11 Jan 2012 17:51:12 +0100

Conclusions Collectively, these data demonstrated that tumorspheres derived from PCa cells possess chemoresistant and CSC properties. Our study suggests that the identification of PCa CSCs could provide new insight into the lethal phenotype of PCa and therapeutic implications. Content Type Journal ArticleCategory Original PaperPages 1-12DOI 10.1007/s00432-011-1146-2Authors Linlin Zhang, Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061 ChinaMin Jiao, Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaLei Li, Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061 ChinaDapeng Wu, Department of Urology, The First Affiliated H...

Weight Maintenance In Restaurants

Health News from Medical News Today — Wed, 11 Jan 2012 17:00:00 +0100

According to an investigation by researchers from the University of Texas at Austin, even though eating out often and consuming large portions of food in restaurants can contribute to excess calorie intake and weight gain, individuals can still lose weight while eating out. The study is published in the January/February issue of the Journal of Nutrition Education and Behavior. The researchers enrolled 35 healthy, preimenopausal women aged between 40 to 59 years old who eat out often to participate in the study... (Source: Health News from Medical News Today)

You Don't Need To Stop Eating Out To Lose Weight

Health News from Medical News Today — Wed, 11 Jan 2012 09:00:00 +0100

Going out to eat has become a major part of our culture. Frequently eating out and consuming high-calorie foods in large portions at restaurants can contribute to excess calorie intake and weight gain. However, a study in the January/February 2012 issue of the Journal of Nutrition Education and Behavior demonstrates that individuals can eat out and still lose weight. Investigators from The University of Texas at Austin enrolled 35 healthy, perimenopausal women aged 40 to 59 years who eat out frequently... (Source: Health News from Medical News Today)

Relationships among maternal nutrient intake and placental biomarkers during the 1st trimester in low-income women

Archives of Gynecology and Obstetrics — Tue, 10 Jan 2012 17:00:27 +0100

Conclusions Expression of placental biomarkers in the early weeks of pregnancy may be influenced by intake of nutrients. Understanding the influence of maternal nutrient intake and placental development in the 1st trimester may provide the opportunity to avert the development or blunt the severity of preeclampsia. Content Type Journal ArticleCategory Maternal-Fetal MedicinePages 1-9DOI 10.1007/s00404-011-2213-2Authors Eileen R. Fowles, The University of Texas at Austin, School of Nursing, 1700 Red River Street, Austin, TX 78701-1499, USALorraine O. Walker, The University of Texas at Austin, School of Nursing, 1700 Red River Street, Austin, TX 78701-1499, USAC. Nathan Marti, Division of Statistics and Scientific Computation, The University of Texas at Austin, College...

Eat Out, Lose Weight, Mindfully

Health News from Medical News Today — Tue, 10 Jan 2012 17:00:00 +0100

Eating out frequently and consuming large, energy-rich portions can result in excess calorie intake and weight gain. Now a new study suggests people don't have to stop eating out to lose weight, even if they dine out frequently, as long as they take a mindful approach to eating. A report on the study is scheduled to appear in the January/February 2012 issue of the Journal of Nutrition Education and Behavior. Dr Gayle M. Timmerman, of the University of Texas at Austin led the research... (Source: Health News from Medical News Today)

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Young women often fail to spot their weight gain

EurekAlert! - Medicine and Health — Tue, 10 Jan 2012 05:00:00 +0100

(University of Texas Medical Branch at Galveston) In a study published online and in the March issue of the Journal of Women's Health, University of Texas Medical Branch researchers found that a significant number of women evaluated at six-month intervals did not recognize recent gains in weight. Self-perception of weight gain appears to be significantly influenced by race, ethnicity and contraceptive methods. (Source: EurekAlert! - Medicine and Health)

Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus (AP23573, MK-8669) in a phase 1 clinical trial

Cancer Chemotherapy and Pharmacology — Mon, 09 Jan 2012 19:37:50 +0100

Conclusions Ridaforolimus was shown to inhibit its intended target, mTOR, in PBMCs, skin, and tumors. In PBMCs and skin, inhibition was observed at all dose levels tested, thus supporting but not driving the selection of a recommended phase 2 dose. Content Type Journal ArticleCategory Clinical Trial ReportPages 1-9DOI 10.1007/s00280-011-1813-7Authors Lori Berk, ARIAD Pharmaceuticals, Inc., 26 Landsdowne Street, Cambridge, MA 02139, USAMonica M. Mita, Cancer Therapy and Research Center, Institute for Drug Development, The University of Texas Health Science Center, San Antonio, TX, USAJeff Kreisberg, Cancer Therapy and Research Center, Institute for Drug Development, The University of Texas Health Science Center, San Antonio, TX, USACamille L. Bedrosian, ARIAD Pharmace...

A Unique Manifestation of Pupillary Fatigue in Autoimmune Autonomic Ganglionopathy [Observation]

Archives of Neurology — Mon, 09 Jan 2012 05:00:00 +0100

Conclusions Premature redilation of the pupil is a unique physiological feature seen only in patients with AAG. This phenomenon appears to be a manifestation of pupillary fatigue, a clinical correlate of defective synaptic transmission at the level of autonomic ganglia in antibody-positive AAG. (Source: Archives of Neurology)

Morton Edward Bitterman (1921–2011).

American Psychologist — Mon, 09 Jan 2012 05:00:00 +0100

Presents an obituary for Mortan Edward "Jeff" Bitterman. Bitterman obtained his doctorate in 1945 and remained at Cornell as a professor until moving to the University of Texas (UT) in 1950 at the invitation of K. M. Dallenbach, a former mentor at Cornell. Over his career, Bitterman studied at least a dozen different species (often inventing new apparatus), and found that the laws underlying probability learning, extinction after partial reinforcement, and discrimination reversals differed across vertebrate species. Bitterman was invited to universities in two dozen countries around the world, where he actively promoted keen scientific study of comparative behavior to psychologists and to biologists and neuroscientists who needed the methods of behaviorists to link mechanism to function. H...

Musculoskeletal: what’s different in children? Playing with a friend: hooks fingers in friends t-shirt: left pinky is sore and swollen

Emergency Radiology — Sun, 08 Jan 2012 16:32:08 +0100

Content Type Journal ArticleCategory Original ArticlePages 1-2DOI 10.1007/s10140-011-1015-yAuthors Leonard E. Swischuk, Department of Radiology, University of Texas Medical Branch, Galveston, TX 77555, USA Journal Emergency RadiologyOnline ISSN 1438-1435Print ISSN 1070-3004 (Source: Emergency Radiology)

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CT-guided adrenal biopsy: comparison of ipsilateral decubitus versus prone patient positioning for biopsy approach

European Radiology — Sat, 07 Jan 2012 16:56:31 +0100

Conclusion Ipsilateral adrenal biopsy approach is a less complex, equally reliable and safe compared to the prone approach based on the less frequent use of the OOP approach and the shorter NIT. Key Points • Ipsilateral adrenal biopsy decubitus positioning provides a direct, non-transpulmonary path for sampling • Ipsilateral decubitus positioning reduces the need for potentially dangerous out-of-plane approaches (OOP) • Ipsilateral decubitus and prone positioning are equally reliable and safe techniques Content Type Journal ArticleCategory InterventionalPages 1-7DOI 10.1007/s00330-011-2363-4Authors Bruno C. Odisio, Department of Diagnostic Radiology, Section of Interventional Radiology, The University of Texas M.D. Anders...

Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels

Diabetologia — Fri, 06 Jan 2012 06:43:39 +0100

Conclusions/interpretation GRB10 is critically involved in alpha cell survival and, as a result, plays an important role in regulating basal glucagon secretion and glucose tolerance in adult mice. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-011-2414-zAuthors B. Doiron, Diabetes Division, University of Texas Health Science Center at San Antonio, Mail Code 7886, 7703 Floyd Curl Drive, San Antonio, TX 78299, USAW. Hu, Diabetes Division, University of Texas Health Science Center at San Antonio, Mail Code 7886, 7703 Floyd Curl Drive, San Antonio, TX 78299, USAL. Norton, Diabetes Division, University of Texas Health Science Center at San Antonio, Mail Code 7886, 7703 Floyd Curl Drive, San Antonio, TX 78299, USAR. A. DeFronzo, Diabetes Division,...

10 Gynecologic Cancer Symptoms Women Shouldn't Ignore

M. D. Anderson Cancer Center - News Releases — Fri, 06 Jan 2012 05:00:00 +0100

Pelvic pain and abnormal bleeding aren't the only signs of gynecologic cancer. As part of Cervical Health Awareness Month in January, experts at The University of Texas MD Anderson Cancer Center share other symptoms that often are overlooked. (Source: M. D. Anderson Cancer Center - News Releases)

Cancer-related deaths continue to decline in US

Guardian Unlimited Science — Thu, 05 Jan 2012 20:13:24 +0100

American Cancer Society's annual report cites advances in cancer screening and treatment for falling numbersCancer death rates are continuing to fall, dropping by 1.8% per year in men and 1.6% per year in women between 2004 and 2008, according to the American Cancer Society's annual report on cancer statistics released on Wednesday.Advances in cancer screening and treatment have prevented more than a million total deaths from cancer since the early 1990s, according to the report.But the influential cancer group said new cases of seven less-common cancers rose in the past decade, suggesting more could be done in America's 40-year war on cancer.This year, the cancer group projects 1,638,910 people will be newly diagnosed with cancer and 577,190 people will die from it."The big news this year...

Glucose-Induced Injury In Kidney Cells Reduced By Hydrogen Sulfide: Finding Lays Basis For Studies In Animal Models Of Diabetic Kidney Disease

Health News from Medical News Today — Thu, 05 Jan 2012 08:00:00 +0100

Hydrogen sulfide, a gas notorious for its rotten-egg smell, may have redeeming qualities after all. It reduces high glucose-induced production of scarring proteins in kidney cells, researchers from The University of Texas Health Science Center San Antonio report in the Journal of Biological Chemistry. The paper is scheduled for print publication in early 2012. "There is interest in gases being mediators of biological events," said B.S. Kasinath, M.D... (Source: Health News from Medical News Today)

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Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case–control study

Breast Cancer Research and Treatment — Wed, 04 Jan 2012 17:02:23 +0100

Abstract Hypersensitivity to radiation exposure has been suggested to be a risk factor for the development of breast cancer. In this case–control study of 515 young women (≤55 years) with newly diagnosed sporadic breast cancer and 402 cancer-free controls, we examined the radiosensitivity as measured by the frequency of chromatid breaks induced by gamma-radiation exposure in the G2 phase of phytohemagglutinin-stimulated and short-term cultured fresh lymphocytes. We found that the average chromatid breaks per cell from 50 well-spread metaphases were statistically significantly higher in 403 non-Hispanic White breast cancer patients (0.52 ± 0.22) than that in 281 non-Hispanic White controls (0.44 ± 0.16) (P value < 0.001), and in 60...

The potential role of glutamate in the current diabetes epidemic

Acta Diabetologica — Wed, 04 Jan 2012 16:59:49 +0100

Abstract In the present article, we propose the perspective that abnormal glutamate homeostasis might contribute to diabetes pathogenesis. Previous reports and our recent data indicate that chronically high extracellular glutamate levels exert direct and indirect effects that might participate in the progressive loss of β-cells occurring in both T1D and T2D. In addition, abnormal glutamate homeostasis may impact all the three accelerators of the “accelerator hypothesis” and could partially explain the rising frequency of T1D and T2D. Content Type Journal ArticleCategory Review ArticlePages 1-17DOI 10.1007/s00592-011-0364-zAuthors Alberto M. Davalli, Diabetes and Endocrinology Unit, Department of Internal Medicine, San Raffaele Scientific Institute, 20132 Milan, I...

A phase II study to evaluate the efficacy and toxicity of oxaliplatin in combination with gemcitabine in carcinoma of unknown primary

International Journal of Clinical Oncology — Wed, 04 Jan 2012 16:48:13 +0100

Conclusions Gemcitabine and oxaliplatin is a well-tolerated regimen in CUP with similar outcomes to previously documented CUP studies. In selected good performance status patients this combination may serve as a first-line doublet chemotherapy option for CUP patients (clinicaltrials.gov ID:NCT00353145). Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s10147-011-0366-4Authors Heather Carlson, Department of Gastrointestinal Medical Oncology, University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 426, Houston, TX 77030, USARenato Lenzi, Department of Gastrointestinal Medical Oncology, University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 426, Houston, TX 77030, USAMartin N. Raber, Department of Gastroin...

Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes

Journal of Molecular Medicine — Wed, 04 Jan 2012 06:58:42 +0100

Abstract Type II collagen is a marker of articular cartilage encoded by the COL2A1 gene. The nature of the trans factors involved in the upregulation of this gene by insulin-like growth factor-I (IGF-I) remains unclear. We found that IGF-I increased type II collagen synthesis by a transcriptional control mechanism involving a 715-bp region within the COL2A1 first-intron specific enhancer. The overproduction of L-Sox5/Sox6/Sox9 and Sp1 and decoy experiments targeting these factors demonstrated their action in concert in IGF-I trans-activation. These results were supported by the data obtained in knockdown experiments in which siRNA against Sox9/Sox6 and Sp1 prevented the IGF-I-induced increase in collagen II production. Indeed, each of these trans-activators increased the expr...

Utilization of Hepatocellular Carcinoma Surveillance Among American Patients: A Systematic Review

Journal of General Internal Medicine — Wed, 04 Jan 2012 06:56:37 +0100

CONCLUSIONS Utilization rates for HCC surveillance are low, although they are significantly higher among patients followed in subspecialty clinics. Current studies fail to determine why HCC surveillance is not being performed. Future efforts should focus on identifying appropriate intervention targets to increase surveillance rates and reduce socio-demographic disparities. Content Type Journal ArticleCategory ReviewsPages 1-7DOI 10.1007/s11606-011-1952-xAuthors Amit G. Singal, Division of Gastroenterology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USAAdam Yopp, Department of Surgery, University of Texas Southwestern, Dallas, TX, USACelette S. Skinner, Department of Clinical Sciences, University of Texas Southwestern, Dallas, TX, US...

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Transitioning from Stratus OCT to Cirrus OCT using Lin’s concordance coefficient

Graefe's Archive for Clinical and Experimental Ophthalmology — Wed, 04 Jan 2012 06:46:56 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00417-011-1899-yAuthors Gelareh Abedi, Vitreoretinal Disease and Surgery, University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Drive, MC 6230, San Antonio, TX 78229-3900, USAGheorghe Doros, Department of Biostatistics, Boston University School of Public Health, 801Massachussetts Avenue, Boston, MA 02118, USAManju L. Subramanian, Department of Ophthalmology, Boston University School of Medicine, 85 East Concord Street, Boston, MA 02118, USA Journal Graefe's Archive for Clinical and Experimental OphthalmologyOnline ISSN 1435-702XPrint ISSN 0721-832X (Source: Graefe's Archive for Clinical and Experimental Ophthalmology)

UTHealth Researchers Link Multiple Sclerosis To Different Area Of Brain

Health News from Medical News Today — Tue, 03 Jan 2012 08:00:00 +0100

Radiology researchers at The University of Texas Health Science Center at Houston (UTHealth) have found evidence that multiple sclerosis affects an area of the brain that controls cognitive, sensory and motor functioning apart from the disabling damage caused by the disease's visible lesions. The thalamus of the brain was selected as the benchmark for the study conducted by faculty at the UTHealth Medical School. Lead researchers include Khader M. Hasan, Ph.D., associate professor, and Ponnada A. Narayana, Ph.D... (Source: Health News from Medical News Today)

Previously Unconnected Molecular Networks Conspire To Promote Cancer

Health News from Medical News Today — Tue, 03 Jan 2012 08:00:00 +0100

An inflammation-promoting protein triggers deactivation of a tumor-suppressor that usually blocks cancer formation via the NOTCH signaling pathway, a team of researchers led by scientists at The University of Texas MD Anderson Cancer Center reports today in Molecular Cell. Working in liver cancer cell lines, the team discovered a mechanism by which tumor necrosis factor alpha (TNFÎ±) stimulates tumor formation, said senior author Mien-Chie Hung, Ph.D., professor and chair of MD Anderson's Department of Molecular and Cellular Oncology... (Source: Health News from Medical News Today)

New nursing program said more 'real life'

Health News - UPI.com — Tue, 03 Jan 2012 05:59:24 +0100

HOUSTON, Jan. 3 (UPI) -- Students get more real-world training in the University of Texas Health Science Center at Houston's redesigned, four-semester nursing program, officials say. (Source: Health News - UPI.com)

Hydrogen sulfide reduces glucose-induced injury in kidney cells

EurekAlert! - Medicine and Health — Tue, 03 Jan 2012 05:00:00 +0100

(University of Texas Health Science Center at San Antonio) Hydrogen sulfide, a noxious gas that smells like rotten eggs, may have beneficial effects in the kidney. Researchers at The University of Texas Health Science Center San Antonio found that this gas diminishes high glucose-induced production of scarring proteins in kidney cells. Considerable work remains to be done before studies can move to animal models. (Source: EurekAlert! - Medicine and Health)

Sea Snails Help Scientists Explore A Possible Way To Enhance Memory

Health News from Medical News Today — Sun, 01 Jan 2012 08:00:00 +0100

Efforts to help people with learning impairments are being aided by a species of sea snail known as Aplysia californica. The mollusk, which is used by researchers to study the brain, has much in common with other species including humans. Research involving the snail has contributed to the understanding of learning and memory. At The University of Texas Health Science Center at Houston (UTHealth), neuroscientists used this animal model to test an innovative learning strategy designed to help improve the brain's memory and the results were encouraging... (Source: Health News from Medical News Today)

Morton edward bitterman (1921-2011).

The American Psychologist — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Balsam P Abstract Presents an obituary for Mortan Edward "Jeff" Bitterman. Bitterman obtained his doctorate in 1945 and remained at Cornell as a professor until moving to the University of Texas (UT) in 1950 at the invitation of K. M. Dallenbach, a former mentor at Cornell. Over his career, Bitterman studied at least a dozen different species (often inventing new apparatus), and found that the laws underlying probability learning, extinction after partial reinforcement, and discrimination reversals differed across vertebrate species. Bitterman was invited to universities in two dozen countries around the world, where he actively promoted keen scientific study of comparative behavior to psychologists and to biologists and neuroscientists who needed the methods of behavioris...

Evaluating the PCPT risk calculator in ten international biopsy cohorts: results from the Prostate Biopsy Collaborative Group

World Journal of Urology — Fri, 30 Dec 2011 16:42:02 +0100

Conclusions External validation of the PCPTRC across ten cohorts revealed varying degree of success highly dependent on the cohort, most likely due to different criteria for and work-up before biopsy. Future validation studies of new calculators for prostate cancer should acknowledge the potential impact of the specific cohort studied when reporting successful versus failed validation. Content Type Journal ArticleCategory Topic PaperPages 1-7DOI 10.1007/s00345-011-0818-5Authors Donna P. Ankerst, Department of Urology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USAAndreas Boeck, Technische Universitaet Muenchen, Garching, GermanyStephen J. Freedland, Durham VA Medical Center and Duke University, Durham, NC, U...

Stress response and procedural pain in the preterm newborn: the role of pharmacological and non-pharmacological treatments

European Journal of Pediatrics — Fri, 30 Dec 2011 07:11:09 +0100

Conclusions: The findings of this study suggest that FE and SS provide a superior analgesia in preterm neonates during procedural pain. In particular, sensorial saturation seems to be an important non-pharmacological alternative treatment to prevent and reduce the procedural pain in preterm newborn. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00431-011-1655-7Authors Eloisa Gitto, Neonatal Intensive Care Unit, Department of Pediatrics, University of Messina, Via Consolare Valeria, CAP 98100 Messina, ItalySalvatore Pellegrino, Ph.D. Fellowship in Clinical and Bio-molecular Hepato-Gastroenterology of Paediatric and Adult Age, University Hospital “G. Martino”, Messina, ItalyMaria Manfrida, Neonatal Intensive Care Unit, Department of Pediatrics, Unive...

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Population pharmacokinetic and exposure-response analysis of nilotinib in patients with newly diagnosed Ph+ chronic myeloid leukemia in chronic phase

European Journal of Clinical Pharmacology — Fri, 30 Dec 2011 07:09:47 +0100

Conclusions There is a less than proportional dose-exposure relationship between nilotinib 300 mg and 400 mg twice-daily doses. Blood level testing is unlikely to play an important role in the general management of patients with newly diagnosed CML treated with nilotinib. Content Type Journal ArticleCategory Pharmacokinetics and DispositionPages 1-11DOI 10.1007/s00228-011-1200-7Authors Richard A. Larson, University of Chicago, Chicago, IL, USAOphelia Q. P. Yin, Novartis Pharmaceuticals Corporation, Florham Park, NJ, USAAndreas Hochhaus, Universitätsklinikum Jena, Jena, GermanyGiuseppe Saglio, University of Turin, Orbassano, ItalyRichard E. Clark, Royal Liverpool University Hospital, Liverpool, UKHirohisa Nakamae, Osaka City University, Osaka, JapanNeil J....

Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone

Journal of Molecular Medicine — Fri, 30 Dec 2011 07:09:18 +0100

This study aimed to evaluate the therapeutic efficacy of BKM120 in multiple myeloma (MM). BKM120 induces cell growth inhibition and apoptosis in both MM cell lines and freshly isolated primary MM cells. However, BKM120 only shows limited cytotoxicity toward normal lymphocytes. The presence of MM bone marrow stromal cells, insulin-like growth factor, or interleukin-6 does not affect BKM120-induced tumor cell apoptosis. More importantly, BKM120 treatment significantly inhibits tumor growth in vivo and prolongs the survival of myeloma-bearing mice. In addition, BKM120 shows synergistic cytotoxicity with dexamethasone in dexamethasone-sensitive MM cells. Low doses of BKM120 and dexamethasone, each of which alone has limited cytotoxicity, induce significant cell apoptosis in MM.1S and ARP...

Sensitivity to apomorphine-induced yawning and hypothermia in rats eating standard or high-fat chow

Psychopharmacology — Fri, 30 Dec 2011 06:50:26 +0100

Conclusions Eating high-fat chow or restricting access to food alters sensitivity to direct-acting dopamine receptor agonists (apomorphine, quinpirole), although the relative contribution of drug history and dietary conditions to sensitivity changes appears to vary among agonists. Content Type Journal ArticleCategory Original InvestigationPages 1-10DOI 10.1007/s00213-011-2620-xAuthors Michelle G. Baladi, Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USAYvonne M. Thomas, Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USACharles P. France, Department of Pharmacology, University of Texas Hea...

Age-stratified phase I trial of a combination of bortezomib, gemcitabine, and liposomal doxorubicin in patients with advanced malignancies

Cancer Chemotherapy and Pharmacology — Wed, 28 Dec 2011 16:45:19 +0100

Conclusion Combination of bortezomib, gemcitabine, and liposomal doxorubicin is well tolerated, but with a lower recommended phase II dose in elderly patients, and demonstrated antitumor activity, especially in T-cell and small cell histology malignancies. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s00280-011-1808-4Authors G. S. Falchook, Division of Cancer Medicine, Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program)-Unit 455, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USAM. Duvic, Division of Internal Medicine, Department of Dermatology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USAD. S. Hong, Divis...

The World Molecular Imaging Society (WMIS)

Molecular Imaging and Biology — Wed, 28 Dec 2011 06:54:26 +0100

Content Type Journal ArticleCategory EditorialPages 1-3DOI 10.1007/s11307-011-0536-9Authors Robert J. Gillies, H Lee Moffitt Cancer Center and Research Institute, Cancer Ecology, Tampa, FL, USAJuri Gelovani, University of Texas, MD Anderson Cancer Center, Houston, TX, USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology)

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Bevacizumab for glioblastoma refractory to vascular endothelial growth factor receptor inhibitors

Journal of Neuro-Oncology — Wed, 28 Dec 2011 06:53:39 +0100

We report our experience with bevacizumab (BEV), a VEGF targeting antibody, following failure of a VEGF receptor targeting tyrosine kinase inhibitor (TKI). We retrospectively identified patients treated on clinical trials with VEGFR–TKIs for recurrent GBM followed by BEV at next recurrence. Survival was estimated by the Kaplan–Meier method. Fourteen patients were identified (six women; median age 57). All received VEGFR–TKIs (sunitinib 11, cediranib 2, sorafenib 1) then BEV at next recurrence. There were no radiographic responses to VEGFR–TKIs; best response was stable disease in 50% (7/14). Patients received BEV alone (21%, 3/14) or in combination with chemotherapy (79%, 11/14). On BEV, 29% (4/14) had a partial response, and 36% (5/14) stabilized. Of evaluable patients, 42% ...

Adherence of stem cell transplant recipients receiving glucocorticoid therapy to an exercise-based rehabilitation program

Supportive Care in Cancer — Tue, 27 Dec 2011 16:49:46 +0100

Abstract The high acuity of hematopoietic stem cell transplant (HSCT) recipients receiving glucocorticoid (GC) therapy for acute graft vs. host disease (aGVHD) may limit their adherence to an exercise-based rehabilitation program and hence, slow their recovery. To make this determination, the medical records of 59 subacute outpatient stem cell transplant recipients receiving methylprednisolone (MP) were reviewed for demographic, anthropometric and medical information. Performance on the repeated sit-to-stand, 50-ft walk and 6-min walk tests were determined before and after completing a 4-week progressive exercise rehabilitation program and outcomes were compared by a paired t-test (P < 0.05). Thirty-two patients (54%) finished a treatment plan (adherent group), compl...

Importance of prostate volume in the European Randomised Study of Screening for Prostate Cancer (ERSPC) risk calculators: results from the prostate biopsy collaborative group

World Journal of Urology — Tue, 27 Dec 2011 16:49:34 +0100

Conclusions Identifying men at increased risk for having a biopsy detectable prostate cancer should consider multiple factors, including an estimate of prostate volume. Content Type Journal ArticleCategory Topic PaperPages 1-7DOI 10.1007/s00345-011-0804-yAuthors Monique J. Roobol, Department of Urology, Erasmus University Medical Centre, P.O Box 2010, 3000 CA Rotterdam, The NetherlandsF. H. Schröder, Department of Urology, Erasmus University Medical Centre, P.O Box 2010, 3000 CA Rotterdam, The NetherlandsJonas Hugosson, Sahlgrenska University Hospital, Goteborg, SwedenJ. Stephen Jones, Cleveland Clinic Foundation, Cleveland, OH, USAMichael W. Kattan, Cleveland Clinic Foundation, Cleveland, OH, USAEric A. Klein, Cleveland Clinic Foundation, Cleveland, OH, USAFreddie ...

All It Takes Is A Smile (For Some Guys)...

Health News from Medical News Today — Sun, 25 Dec 2011 08:00:00 +0100

Does she or doesn't she . . .? Sexual cues are ambiguous, and confounding. We - especially men - often read them wrong. A new study hypothesizes that the men who get it wrong might be the ones that evolution has favored. "There are tons of studies showing that men think women are interested when they're not," says Williams College psychologist Carin Perilloux, who conducted the research with Judith A. Easton and David M. Buss of University of Texas at Austin. "Ours is the first to systematically examine individual differences... (Source: Health News from Medical News Today)

Sea snails help scientists explore a possible way to enhance memory

EurekAlert! - Biology — Sun, 25 Dec 2011 05:00:00 +0100

(University of Texas Health Science Center at Houston) Efforts to help people with learning impairments are being aided by a species of sea snail. The mollusk, which is used by researchers to study the brain, has much in common with other species including humans. At the University of Texas Health Science Center at Houston, neuroscientists used this animal model to test an innovative learning strategy designed to help improve the brain's memory and the results were encouraging. (Source: EurekAlert! - Biology)

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Spiral Assisted ERCP Is Equivalent to Single Balloon Assisted ERCP in Patients with Roux-en-Y Anatomy

Digestive Diseases and Sciences — Sat, 24 Dec 2011 16:42:21 +0100

Conclusion Diagnostic and therapeutic yields are similar with SBE-ERCP and SE-ERCP in patients with Roux-en-Y anatomy with no significant difference in procedure time or complication rates. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s10620-011-2000-8Authors Anne Marie Lennon, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, 1830 East Monument Street, Baltimore, MD 21205, USASumit Kapoor, Sinai Hospital Program in Internal Medicine, Johns Hopkins University, Baltimore, MD, USAMouen Khashab, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, 1830 East Monument Street, Baltimore, MD 21205, USAErin Corless, Department of Epidemiology, Johns Hopkins Bloomberg Sch...

Use of Nucleoside (Tide) Analogues in Patients with Hepatitis B-Related Acute Liver Failure

Digestive Diseases and Sciences — Sat, 24 Dec 2011 16:42:20 +0100

Conclusions Patients who are admitted with established HBV-ALF do not appear to benefit from viral suppression using nucleoside(tide) analogues presumably because of rapid disease evolution and short treatment duration. Despite the lack of benefit, NAs should still be given to transplantation candidates since viral suppression prevents recurrence after grafting. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s10620-011-2013-3Authors Doan Y. Dao, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USAEmmanuel Seremba, Makerere University Medical School, Kampala, UgandaVeeral Ajmera, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USAC...

The Role of Trust in Delayed HIV Diagnosis in a Diverse, Urban Population

AIDS and Behavior — Sat, 24 Dec 2011 16:42:00 +0100

Abstract Delayed diagnosis of HIV infection is a common problem. We hypothesized that persons with less trust in physicians and in the healthcare system would be diagnosed with lower CD4 cell counts than persons with more trust because they would delay seeking healthcare. From January 2006 to October 2007, 171 newly diagnosed HIV-infected persons, not yet in HIV primary care, were recruited from HIV testing sites in Houston, Texas, that primarily serve the under- and un-insured. The participants completed instruments measuring trust in physicians and trust in the healthcare system. Initial CD4 cell counts were obtained from medical record review. Mean trust scores for participants with CD4 cell counts ≥200 cells/mm3 were compared with scores from participants with CD...

Risk indicators for the presence and extent of root caries among caries-active adults enrolled in the Xylitol for Adult Caries Trial (X-ACT)

Clinical Oral Investigations — Fri, 23 Dec 2011 16:52:44 +0100

We examined associations between baseline characteristics and (1) the presence of any root caries using Mantel–Haenszel hypothesis tests and odds ratio (OR) estimators and (2) the number of root surfaces with caries among study participants with exposed root surfaces (n = 349) using Mantel–Haenszel mean score tests and Mann–Whitney estimators. Results/conclusions Adjusting for study site and age, male gender [OR, 1.72; 95% confidence interval (CI), 1.08, 2.78], white race (OR, 2.39; 95% CI, 1.43, 3.98), recent dental visit (OR, 1.98; 95% CI, 1.07, 3.66), poor self-described oral health (OR, 2.65; 95% CI, 1.10, 6.39), and recent professional fluoride treatment (OR, 1.85; 95% CI, 1.06, 3.25) were significantly associated with increased odds to have any root...

Exploiting antitumor immunity to overcome relapse and improve remission duration

Cancer Immunology, Immunotherapy — Fri, 23 Dec 2011 16:51:27 +0100

Abstract Cancer survivors often relapse due to evolving drug-resistant clones and repopulating tumor stem cells. Our preclinical study demonstrated that terminal cancer patient’s lymphocytes can be converted from tolerant bystanders in vivo into effective cytotoxic T-lymphocytes in vitro killing patient’s own tumor cells containing drug-resistant clones and tumor stem cells. We designed a clinical trial combining peginterferon α-2b with imatinib for treatment of stage III/IV gastrointestinal stromal tumor (GIST) with the rational that peginterferon α-2b serves as danger signals to promote antitumor immunity while imatinib’s effective tumor killing undermines tumor-induced tolerance and supply tumor-specific antigens in vivo without leukopenia, thus allowing for pro...

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Potential for prostate cancer prevention through physical activity

World Journal of Urology — Fri, 23 Dec 2011 16:51:22 +0100

Conclusions There is a growing body of epidemiological research suggesting that physical activity is protective against the development of prostate cancer. This paper reviewed 22 studies published in the past 12 years updating an earlier review finding that although some studies show no benefit and a very few show increased risk for prostate cancer, the majority of studies document a significant, albeit small, protective effect of physical activity. Content Type Journal ArticleCategory Topic paperPages 1-13DOI 10.1007/s00345-011-0812-yAuthors Stacey Young-McCaughan, Division of Behavioral Medicine, Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7550 IH10 West, Suite 1325, San Antonio, TX 78229-5820, USA Journal World...

Previously Unconnected Molecular Networks Conspire To Promote Cancer

Health News from Medical News Today — Fri, 23 Dec 2011 09:00:00 +0100

An inflammation-promoting protein triggers deactivation of a tumor-suppressor that usually blocks cancer formation via the NOTCH signaling pathway, a team of researchers led by scientists at The University of Texas MD Anderson Cancer Center reports in Molecular Cell. Working in liver cancer cell lines, the team discovered a mechanism by which tumor necrosis factor alpha (TNFÎ±) stimulates tumor formation, said senior author Mien-Chie Hung, Ph.D., professor and chair of MD Anderson's Department of Molecular and Cellular Oncology. Hung also is MD Anderson's vice president for basic research... (Source: Health News from Medical News Today)

Parents May Hold Key to Healthy Weight in Hispanic Kids

RWJF News Digest - Childhood Obesity — Fri, 23 Dec 2011 05:00:00 +0100

Parents of overweight Hispanic children are willing to make food and lifestyle changes that will benefits their kids' health, a new study suggests. The findings may help improve efforts to combat the childhood obesity epidemic among Hispanic Americans, the largest and fastest-growing ethnic group in the United States, said the researchers at University of Texas Southwestern Medical Center in Dallas. (Source: RWJF News Digest - Childhood Obesity)

Technical Feasibility of Robot-Assisted Ventral Hernia Repair

World Journal of Surgery — Thu, 22 Dec 2011 16:38:08 +0100

Conclusions This is a retrospective series review of robot-assisted ventral hernia repair using intracorporeal primary closure followed by continuous running, circumferential fixation. The findings show that this technique is feasible and may not be associated with chronic postoperative pain. Further evaluation is needed, and long-term data are lacking to assess the benefit to the patient, but this series can be the basis for future studies. Content Type Journal ArticlePages 1-6DOI 10.1007/s00268-011-1389-8Authors Nathan Allison, Department of Surgery, Health Sciences Center at Houston, University of Texas, 6431 Fannin Street, Suite 4.294, Houston, TX 77030, USAKen Tieu, Department of Surgery, Health Sciences Center at Houston, University of Texas, 6431 Fannin Stre...

Recommendations from an International Consensus Conference on the Current Status and Future of Neoadjuvant Systemic Therapy in Primary Breast Cancer

Annals of Surgical Oncology — Thu, 22 Dec 2011 16:37:01 +0100

Abstract The use of neoadjuvant systemic therapy (NST) for the treatment of primary breast cancer has constantly increased, especially in trials of new therapeutic regimens. In the 1980 s, NST was shown to substantially improve breast-conserving surgery rates and was first typically used for patients with inoperable locally advanced or inflammatory breast cancer. Investigators have since also used NST as an in vivo test for chemosensitivity by assessing pathologic complete response. Today, by using pathologic response and other biomarkers as intermediate end points, results from trials of new regimens and therapies that use NST are aimed to precede and anticipate the results from larger adjuvant trials. In 2003, a panel of representatives from various breast cancer cl...

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New Approach To Nursing Education Gives Students The Chance To 'Live Like A Nurse'

Health News from Medical News Today — Thu, 22 Dec 2011 09:00:00 +0100

Since they were pre-teens, Kathrine McKay and Kathryn Lito had aspirations of pursuing a nursing career. So when they applied to the Bachelor of Science in Nursing (B.S.N.) program at The University of Texas Health Science Center at Houston (UTHealth) School of Nursing, they decided to take an accelerated approach to their education with the new Pacesetters program. A redesigning of the four-semester B.S.N... (Source: Health News from Medical News Today)

Medicare And Private Insurance Spending Similar Throughout Texas

Health News from Medical News Today — Thu, 22 Dec 2011 09:00:00 +0100

Variations in health care spending by Medicare and Blue Cross Blue Shield of Texas (BCBSTX) are similar throughout the state despite previous research, which found significant spending differences between the private and commercial sector in McAllen, Texas. The latest research results from The University of Texas Health Science Center at Houston (UTHealth), the Commonwealth Fund, and the Brookings Institution are published in The American Journal of Managed Care's December web exclusive issue... (Source: Health News from Medical News Today)

University of Texas chemist receives major grant to improve detection of drug-resistant tuberculosis

EurekAlert! - Medicine and Health — Thu, 22 Dec 2011 05:00:00 +0100

(University of Texas at Austin) Developing a simple, paper-based test for drug-resistant tuberculosis is the goal of a University of Texas at Austin chemist, whose project just received a $1.6 million point-of-care diagnostics grant through Grand Challenges in Global Health, an initiative created by the Bill & Melinda Gates Foundation. (Source: EurekAlert! - Medicine and Health)

Previously unconnected molecular networks conspire to promote cancer

EurekAlert! - Medicine and Health — Thu, 22 Dec 2011 05:00:00 +0100

(University of Texas M. D. Anderson Cancer Center) An inflammation-promoting protein triggers deactivation of a tumor-suppressor that usually blocks cancer formation via the NOTCH signaling pathway, a team of researchers led by scientists at the University of Texas MD Anderson Cancer Center reports today in Molecular Cell. (Source: EurekAlert! - Medicine and Health)

UTHealth researchers link multiple sclerosis to different area of brain

EurekAlert! - Social and Behavioral Science — Thu, 22 Dec 2011 05:00:00 +0100

(University of Texas Health Science Center at Houston) Radiology researchers at the University of Texas Health Science Center at Houston (UTHealth) have found evidence that multiple sclerosis affects an area of the brain that controls cognitive, sensory and motor functioning apart from the disabling damage caused by the disease's visible lesions. (Source: EurekAlert! - Social and Behavioral Science)

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Baptist Health Foundation approves new round of funding to Health Science Center

bizjournals.com Health Care:Physician Practices headlines — Wed, 21 Dec 2011 21:49:43 +0100

Baptist Health Foundation officials awarded $336,000 to the University of Texas Health Science Center at San Antonio to support scholarships and community service learning. About $215,000 are earmarked for 58 scholarships for students in the School of Medicine, School of Nursing, Dental School and School of Health Professions. “You have made it possible for our students to obtain a health care degree and become tomorrow’s leaders,” William L. Henrich, president of the Health Science Center, said to the members of the foundation’s board of trustees... (Source: bizjournals.com Health Care:Physician Practices headlines)

A Population-Based Comparison of Adenocarcinoma of the Large and Small Intestine: Insights Into a Rare Disease

Annals of Surgical Oncology — Wed, 21 Dec 2011 20:14:28 +0100

Conclusions Adequate nodal assessment is much less common in SBA than LBA; and it appears that SBA, in particular duodenal adenocarcinoma, is understaged. Even after corrections to minimize the effect of stage migration and inadequate lymph node evaluation, SBA demonstrated distinctly worse CSS than LBA. Content Type Journal ArticleCategory Healthcare Policy and OutcomesPages 1-7DOI 10.1245/s10434-011-2173-6Authors Michael J. Overman, Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAChung-Yuan Hu, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USAScott Kopetz, Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Hous...

Research finds Medicare and private insurance spending similar throughout Texas

EurekAlert! - Social and Behavioral Science — Wed, 21 Dec 2011 05:00:00 +0100

(University of Texas Health Science Center at Houston) Variations in health care spending by Medicare and Blue Cross Blue Shield of Texas are similar throughout the state despite previous research, which found significant spending differences between the private and commercial sector in McAllen, Texas. (Source: EurekAlert! - Social and Behavioral Science)

Does This Animal Live Unusually Long? [Slide Show]

Scientific American - Official RSS Feed — Tue, 20 Dec 2011 22:15:00 +0100

Steven Austad , of the Barshop Institute for Longevity and Aging Studies, at the University of Texas Health Science Center at San Antonio, has applied the longevity quotient--which he developed--to many species, including those depicted here. The quotient is determined by dividing the greatest recorded longevity for a species by the life span that would be expected based on the species's average weight. Except for humans and Brandt's bat, the scores refer to animals in captivity. [More] (Source: Scientific American - Official RSS Feed)

Comments on “Essential Thrombocytosis and Antiphospholipid Antibody Syndrome Causing Chronic Budd-Chiari Syndrome”

Indian Journal of Pediatrics — Tue, 20 Dec 2011 06:47:33 +0100

Content Type Journal ArticleCategory CorrespondencePages 1-2DOI 10.1007/s12098-011-0627-2Authors Thein H. Oo, Department of Medicine, Section of Thrombosis and Benign Hematology, The University of Texas M. D. Anderson Cancer Center, 1400 Pressler Street, Unit 1464, Houston, TX 77030, USA Journal Indian Journal of PediatricsOnline ISSN 0973-7693Print ISSN 0019-5456 (Source: Indian Journal of Pediatrics)

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Vitamin D supplementation during exercise training does not alter inflammatory biomarkers in overweight and obese subjects

European Journal of Applied Physiology — Mon, 19 Dec 2011 16:52:15 +0100

Abstract The purpose of this study was to examine the effects of vitamin D supplementation on inflammatory biomarkers in overweight and obese adults participating in a progressive resistance exercise training program. Twenty-three (26.1 ± 4.7 years) overweight and obese (BMI 31.3 ± 3.2 kg/m2) adults were randomized into a double-blind vitamin D supplementation (Vit D 4,000 IU/day; female 5, male 5) or placebo (PL, female 7; male 6) intervention trial. Both groups performed 12 weeks (3 days/week) of progressive resistance exercise training (three sets of eight exercises) at 70–80% of one repetition maximum. Whole-blood lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) α production as well as circulating C-reacti...

Study reveals turn 'signals' for neuron growth

EurekAlert! - Medicine and Health — Mon, 19 Dec 2011 05:00:00 +0100

(University of California - Irvine) Researchers at UC Irvine and The University of Texas at Arlington have discovered how spinning microparticles can direct the growth of nerve fiber, a discovery that could allow for directed growth of neuronal networks on a chip and improve methods for treating spinal or brain injuries. (Source: EurekAlert! - Medicine and Health)

Re: Clinical Outcomes After Combined Therapy With Dutasteride Plus Tamsulosin or Either Monotherapy in Men With Benign Prostatic Hyperplasia (BPH) by Baseline Characteristics: 4-Year Results From the Randomized, Double-Blind Combination of Avodart and Tamsulosin (CombAT) Trial

The Journal of Urology — Mon, 19 Dec 2011 05:00:00 +0100

C. G. Roehrborn, J. Barkin, P. Siami, A. Tubaro, T. H. Wilson, B. B. Morrill and R. P. Gagnier Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas (Source: The Journal of Urology)

A cluster of transcripts encoded by KSHV ORF30-33 gene locus

Virus Genes — Fri, 16 Dec 2011 16:54:28 +0100

Abstract Kaposi’s sarcoma-associated herpesvirus ORF30-33 locus encodes four genes with unknown functions. We performed transcriptional mapping of these genes. Northern-hybridization, 5′- and 3′-rapid amplification of cDNA ends, and DNA sequencing identified four transcripts of 3.7, 3.6, 2.7, and 1.4 kb, none of which has alternative splicing. While all transcripts have the same termination site, their start sites vary. All transcripts are not expressed or only weakly expressed in latent cells but can be chemically induced. The 3.7 and 3.6 kb transcripts contain all four genes and are sensitive to cycloheximide (CH) but resistant to phosphonoacetic acid (PAA), indicating that they are early lytic transcripts. The 2.7 kb transcript contains ORF32 and OR...

Insulin Signaling Is Distorted In Pancreases Of Type 2 Diabetics

Health News from Medical News Today — Fri, 16 Dec 2011 08:00:00 +0100

Insulin signaling is altered in the pancreas, a new study shows for the first time in humans. The errant signals disrupt both the number and quality of beta cells - the cells that produce insulin. The finding is described in the journal PLoS ONE. Franco Folli, M.D., Ph.D., of the School of Medicine at The University of Texas Health Science Center San Antonio, and Rohit Kulkarni, M.D., Ph.D., of the Joslin Diabetes Center, Harvard Medical School, Boston, are principal investigators of the study... (Source: Health News from Medical News Today)

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Prognostic factors in mucoepidermoid carcinoma of the salivary glands

Cancer — Fri, 16 Dec 2011 05:00:00 +0100

CONCLUSIONS:Patients with either low‐ or intermediate‐grade tumors uniformly have favorable local control and survival. High histological grade, advanced stage, perineural invasion, positive surgical margins, and submandibular location all portend for poor outcomes in MEC. Further advances in therapy are needed to improve outcomes for high‐grade and advanced‐stage disease. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer)

NRAS mutation status is an independent prognostic factor in metastatic melanoma

Cancer — Fri, 16 Dec 2011 05:00:00 +0100

CONCLUSIONS:Patients with BRAF or NRAS mutations were more likely than WT patients to have central nervous system involvement at the time they were diagnosed with distant metastatic disease. NRAS mutation status was identified as an independent predictor of shorter survival after a diagnosis of stage IV melanoma. Cancer 2012;. © 2011 American Cancer Society. (Source: Cancer)

Re: Association Between Smoking Cessation and Sexual Health in Men

The Journal of Urology — Fri, 16 Dec 2011 05:00:00 +0100

C. B. Harte and C. M. Meston Department of Psychology, University of Texas at Austin, Austin, Texas (Source: The Journal of Urology)

Prognostic Model Developed For MDS Related To Prior Cancer Therapy

Health News from Medical News Today — Thu, 15 Dec 2011 10:00:00 +0100

A large-scale analysis of patients whose myelodysplastic syndrome is related to earlier cancer treatment overturns the notion that all of them have a poor prognosis, researchers from The University of Texas MD Anderson Cancer Center report at the 53rd Annual Meeting of the American Society of Hematology. "MDS patients whose disease springs from earlier radiation, chemotherapy or both treatments are usually told that they have a poor prognosis... (Source: Health News from Medical News Today)

Imaging Copper Metabolism Imbalance in Atp7b−/− Knockout Mouse Model of Wilson’s Disease with PET-CT and Orally Administered 64CuCl2

Molecular Imaging and Biology — Thu, 15 Dec 2011 06:43:07 +0100

Conclusions PET-CT quantitative analysis demonstrated an increased level of 64Cu radioactivity in the liver of Atp7b −/− KO mice compared with that in the control C57BL WT mice, following oral administration of 64CuCl2 as a tracer. The results of this study suggest the feasibility and utility of PET-CT using orally administered 64CuCl2 as a tracer (64CuCl2-PET/CT) for functional imaging of copper metabolism imbalance in WD. Content Type Journal ArticleCategory Research ArticlePages 1-8DOI 10.1007/s11307-011-0532-0Authors Fangyu Peng, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Hines Blvd, Dallas, TX 75390-8542, USASvetlana Lutsenko, Department of Physiology, Johns Hopkins University, Baltimore, MD, USAXiankai Sun, De...

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Donor-derived isolated del(20q) after hematopoietic stem cell transplantation: report of two cases and review of the literature

Journal of Hematopathology — Wed, 14 Dec 2011 16:30:53 +0100

Content Type Journal ArticleCategory Case ReportPages 1-8DOI 10.1007/s12308-011-0123-7Authors Rashmi Kanagal-Shamanna, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USACarlos E. Bueso-Ramos, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USASu S. Chen, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USALynne V. Abruzzo, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMarcos J. de Lima, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USARachel L. Sargent, Department of Hematopathology, The University of Texas MD Anderson...

Work in cells, animals, patients reveals toxin's role in asthma

EurekAlert! - Medicine and Health — Wed, 14 Dec 2011 05:00:00 +0100

(University of Texas Health Science Center at San Antonio) A swell of evidence from labs and clinical studies is suggesting that a common respiratory bacterial pathogen and the toxin it makes are worsening many asthma cases. (Source: EurekAlert! - Medicine and Health)

AML Patients Have High Response Rate with Vorinostat Added to Treatment

M. D. Anderson Cancer Center - News Releases — Wed, 14 Dec 2011 05:00:00 +0100

AML Patients Have High Response Rate With Vorinostat Added To Treatment

Health News from Medical News Today — Tue, 13 Dec 2011 09:00:00 +0100

Adding a drug that activates genes to frontline combination therapy for acute myeloid leukemia resulted in an 85 percent remission rate after initial treatment, researchers at The University of Texas MD Anderson Cancer Center reported at the 53rd Annual Meeting of the American Society of Hematology. Results of the Phase II clinical trial of 75 patients set the stage for a national Phase III clinical trial of the new combination compared to standard-of-care frontline combinations used at MD Anderson and elsewhere, said study leader Guillermo Garcia-Manero, M.D... (Source: Health News from Medical News Today)