MedWorm: University of Washington

Diabetes Patients' Lives May Be Shorter If They Have Difficulty Trusting And Reaching Out To Others

Health News from Medical News Today — Fri, 19 Mar 2010 07:00:00 +0100

Mistrust can exact a high toll. Being overly cautious or dismissive in relating to people, researchers are learning, may shorten the lives of people with diabetes. Diabetes patients who have a lower propensity to reach out to others have a higher mortality rate than those who feel comfortable seeking support. These are the findings of a five-year study reported by Dr. Paul Ciechanowski, associate professor of psychiatry and behavioral sciences at the University of Washington (UW) and an affiliate investigator at Group Health Research Institute in Seattle... (Source: Health News from Medical News Today)

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UW Department of Global Health and Physicians for Social Responsibility Host War & Global Health Conference April 23-25 on UW Campus

uwnews.org | Health and Medicine — Wed, 17 Mar 2010 19:25:33 +0100

The Eighth Annual Western Regional International Health Conference being held at the University of Washington April 23-25 is on "War & Global Health: Transforming Our Profession, Changing Our World." (Source: uwnews.org | Health and Medicine)

Difficulty trusting and reaching out to others may shorten diabetes patients' lives

EurekAlert! - Social and Behavioral Science — Wed, 17 Mar 2010 04:00:00 +0100

(University of Washington) Being overly cautious or dismissive in relating to others, including health-care providers, may shorten the lives of people with diabetes. In a five-year study, diabetes patients who had a lower propensity to reach out to others had a higher mortality rate than those who felt comfortable seeking support. There are approaches that health-care professionals might try to improve collaboration with patients who have an independent relationship style. (Source: EurekAlert! - Social and Behavioral Science)

Baldness and prostate cancer risk

NHS News Feed — Tue, 16 Mar 2010 16:21:00 +0100

Conclusion Though this study suggests there is an an association between early onset male pattern baldness and risk of prostate cancer, the findings are not conclusive. Its strengths include its relatively large size and that it assessed men’s baldness at a standard point in time (at age 30). However, there are a number of points to consider: Hair loss was assessed retrospectively, and this may reduce the reliability of these reports, particularly for hair loss at age 30, which may become increasingly difficult to recall the further in the past this date was. Some of the analyses of specific subgroups of men, particularly those examining patterns of baldness in men aged 60 and over, only included small numbers of men, and therefore these results should be interpreted cautiously. ...

University of Washington mulls faculty retirement deal

bizjournals.com Health Care:Biotechnology headlines — Mon, 15 Mar 2010 18:58:42 +0100

University of Washington Regents will consider a proposal later this week to offer tenured faculty a new, voluntary retirement incentive. (Source: bizjournals.com Health Care:Biotechnology headlines)

Radiation safety in pediatric interventional radiology: Step Lightly

Pediatric Radiology — Fri, 12 Mar 2010 06:47:53 +0100

Abstract The “Step Lightly” campaign, launched in 2009, is the next phase of the “Image Gently” social marketing campaign, and focuses on improving radiation safety during pediatric interventional radiology procedures. Downloadable content available on the Image Gently website includes parent-friendly information about radiation dose, protocol suggestions and procedure checklists for providers, and information for referring physicians, radiologic technologists and physicists. There are also links to additional reading material and to other relevant organizations. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00247-009-1514-0Authors Manrita Sidhu, University of Washington Seattle Radiologists, Seattle Children’s Hospital 1229 Madison St. Suite 900 S...

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Relaxation therapy for anxiety

NHS News Feed — Thu, 11 Mar 2010 15:33:00 +0100

Conclusion This trial carefully recruited people with diagnosed GAD with the aim of comparing three different relaxation techniques over a period of 12 weeks. However, it has a number of important limitations: There were relatively few participants in each of the three groups. With such small numbers, there is a stronger chance that the findings are due to chance only. Participants could not be blinded to the fact that they were receiving relaxation treatment. Simply by receiving some form of relaxation therapy over 12 weeks may have helped people to feel less anxious. As the researchers admit, a ‘no treatment’ group who received no form of therapy of at all would have addressed some of this uncertainty. This was a specific group of people with diagnosed GAD, a considerable nu...

Conservationists urge treaty panel to reject ivory sale by Tanzania, Zambia

EurekAlert! - Social and Behavioral Science — Thu, 11 Mar 2010 05:00:00 +0100

(University of Washington) An international team of conservationists, writing in Science, says relaxing a current moratorium on ivory sales to allow one-time sales by Zambia and Tanzania could lead to increased slaughter of elephants for their ivory throughout Africa. (Source: EurekAlert! - Social and Behavioral Science)

Depression plus diabetes may = dementia

Health News - UPI.com — Thu, 11 Mar 2010 04:38:53 +0100

SEATTLE, March 10 (UPI) -- Diabetes combined with depression increases dementia risk, University of Washington researchers found. (Source: Health News - UPI.com)

Remission in Juvenile Idiopathic Arthritis: Current Facts

Current Rheumatology Reports — Thu, 11 Mar 2010 02:24:31 +0100

This article focuses on recently developed preliminary criteria for inactive disease and remission in JIA. Recent studies using these new definitions demonstrate only modest rates of achievement of remission favoring children with persistent oligoarticular JIA. Children with rheumatoid factor-positive polyarticular JIA are least likely to achieve remission. Therapeutic strategies to achieve remission are also discussed. Content Type Journal ArticleDOI 10.1007/s11926-010-0085-2Authors Susan Shenoi, University of Washington School of Medicine and Seattle Children’s Hospital Division of Pediatric Rheumatology 4800 Sand Point Way NE Seattle WA 98105 USACarol A. Wallace, University of Washington School of Medicine and Seattle Children’s Hospital Division of Pediatric Rheumatology ...

American Society of Hematology Scholar Awards

ScanGrants feed — Thu, 11 Mar 2010 00:00:00 +0100

The ASH Scholar Awards are designed to support hematologists who have chosen a career in research by providing partial salary or other support during that critical period required for completion of training and achievement of status as an independent investigator. Eligibility Criteria (as of August 26, 2010)To be eligible for the Junior Faculty Scholar Award (either basic or clinical/translational research), applicants must be within the first three years of their initial faculty appointment as Assistant Professor at the time of application.To be eligible for the Fellow Scholar Award (either basic or clinical/translational research), applicants must have more than two years, but less than five years postdoctoral research training at the time of application. Applicants who are fellows mus...

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Inferior vena cava dissection following blunt abdominal trauma

Emergency Radiology — Wed, 10 Mar 2010 15:25:34 +0100

We report a case of IVC dissection from a low-speed motor vehicle collision and discuss its imaging features. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10140-010-0864-0Authors Sandeep S. Vaidya, University of Washington Medical Center Department of Interventional Radiology Box 357115 Seattle WA 98195 USAPuneet Bhargava, University of Washington Medical Center Department of Radiology Box 357115 Seattle WA 98195 USACarrie P. Marder, University of Washington Medical Center Department of Radiology Box 357115 Seattle WA 98195 USAManjiri K. Dighe, University of Washington Medical Center Department of Radiology Box 357115 Seattle WA 98195 USA Journal Emergency RadiologyOnline ISSN 1438-1435Print ISSN 1070-3004 (Source: Emergency Radiology)

Male Batterers Consistently Overestimate General Rates Of Violence Toward Partners

Public Health News From Medical News Today — Wed, 10 Mar 2010 13:00:00 +0100

Male Batterers Consistently Overestimate General Rates Of Violence Toward Partners

Health News from Medical News Today — Wed, 10 Mar 2010 13:00:00 +0100

Men who engaged in domestic violence consistently overestimated how common such behavior is, and the more they overestimated it the more they engaged in abusing their partner in the previous 90 days, according to new research conducted at the University of Washington. Those men overestimated by two to three times the actual rates of seven behaviors ranging from throwing something at a partner to rape, according Clayton Neighbors, lead author of a paper to be published in a spring issue of the journal Violence Against Women... (Source: Health News from Medical News Today)

Male batterers consistently overestimate rates of violence toward partners

EurekAlert! - Social and Behavioral Science — Tue, 09 Mar 2010 05:00:00 +0100

(University of Washington) Men who engaged in domestic violence consistently overestimated how common such behavior is by two or three times, and the more they overestimated it the more they engaged in abusing their partner in the previous 90 days. (Source: EurekAlert! - Social and Behavioral Science)

MLA webcast: Understanding Electronic Health Records

Dragonfly — Mon, 08 Mar 2010 22:06:58 +0100

Join your colleagues on Wednesday, March 24th from 11am-1pm (Pacific time) for the Medical Library Association (MLA) webcast Now’s the Time: Understanding the Electronic Health Record Maze and Health Sciences Librarians’ Roles. The goal of this program is to clarify the terminology surrounding the emerging electronic health information environment and to illustrate how and why health sciences librarians can and should become engaged with the efforts to achieve the national 2014 goal of instituting an electronic health record for each person in the United States. Presenters include Margaret Bandy, AHIP; Janice Willis, Sara Pimental, AHIP; David Sweet, Elaine Alligood, Kelly Near and Annette Williams. The Pacific Northwest Region (PNR) will host the webcast at the University of...

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Routine, Self‐administered, Touch‐Screen, Computer‐Based Suicidal Ideation Assessment Linked to Automated Response Team Notification in an HIV Primary Care Setting

Clinical Infectious Diseases Latest Issue — Mon, 08 Mar 2010 22:02:25 +0100

Discussion. Suicidal ideation was associated with current substance abuse and depression. The use of novel technologies to incorporate routine self‐reported screening for suicidal ideation and other health domains allows for timely detection and intervention for this life‐threatening condition. (Source: Clinical Infectious Diseases Latest Issue)

Discovery Of Gene That Affects Susceptibility To TB And Clues To How It Works

Health News from Medical News Today — Sat, 06 Mar 2010 08:00:00 +0100

University of Washington (UW) researchers have identified a gene involved in susceptibility and resistance to tuberculosis. This same gene, they have found, has a role in the severity of leprosy, which is caused by a related pathogen. The researchers also have learned why this gene is important for susceptibility. The gene, lta4h, appears to orchestrate pro-inflammatory and anti-inflammatory responses. When these responses are balanced, the body destroys invaders without unduly hurting itself. But an imbalance results in problems... (Source: Health News from Medical News Today)

Discovery Of Gene That Affects Susceptibility To TB And Clues To How It Works

Genetics News From Medical News Today — Sat, 06 Mar 2010 08:00:00 +0100

Fossil Pushes Back The Age Of Dinosaurs

NPR Health and Science — Fri, 05 Mar 2010 18:00:00 +0100

A fossil in Tanzania suggests dinosaurs appeared 10 million years earlier than previously thought, according to a Nature study. Christian Sidor, of the Burke Museum of Natural History and Culture at the University of Washington, discusses the origin of dinosaurs.» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)

American Society for Microbiology honors Maynard V. Olson

EurekAlert! - Biology — Fri, 05 Mar 2010 05:00:00 +0100

(American Society for Microbiology) The 2010 American Society for Microbiology Promega Biotechnology Research Award will be presented to Maynard V. Olson, Ph.D., Professor Emeritus of Medicine and Genome Sciences, University of Washington, Seattle, for his work in genomics. Sponsored by Promega Corporation, this award honors outstanding contributions to the application of biotechnology through fundamental microbiological research and development. (Source: EurekAlert! - Biology)

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Major depression more than doubles risk of dementia among adults with diabetes

EurekAlert! - Social and Behavioral Science — Fri, 05 Mar 2010 05:00:00 +0100

(University of Washington) Adults with both depression and diabetes are more than twice as likely to develop dementia compared to those with diabetes alone. Earlier studies have shown that depression alone is a risk factor for dementia, and that diabetes itself is a dementia risk factor. Researchers found even greater risk of dementia in people with both conditions. The mechanisms behind this increased risk are not yet clear. The researchers suggest that physicians screen and treat their diabetes patients for depression, which is common in people with diabetes. (Source: EurekAlert! - Social and Behavioral Science)

Web Test to Measures Prejudice Against Arab Muslims

About.com Mental Health — Fri, 05 Mar 2010 00:00:00 +0100

People can take a five-minute, anonymous Web test that measures their level of unconscious prejudice against Arab Muslims. The test, developed by University of Washington and Yale psychologists, can be accessed on the tolerance.org Web site. (Source: About.com Mental Health)

Researchers discover gene that affects susceptibility to TB and clues to how it works

EurekAlert! - Biology — Thu, 04 Mar 2010 05:00:00 +0100

(University of Washington) Researchers have identified a gene involved in susceptibility and resistance to tuberculosis, and in the severity of leprosy. The gene appears to orchestrate pro- and anti-inflammatory responses. When these are in balance, the body can fight off infection without hurting itself. An imbalance either lets the infection take hold, or damage occurs from an overly aggressive defense. (Source: EurekAlert! - Biology)

American Society for Microbiology honors Caroline S. Harwood

EurekAlert! - Biology — Thu, 04 Mar 2010 05:00:00 +0100

(American Society for Microbiology) The 2010 American Society for Microbiology Procter & Gamble Award in Applied and Environmental Microbiology is being presented to Caroline S. Harwood, Ph.D., Gerald and Lyn Grinstein Professor of Microbiology, the University of Washington, Seattle, for being a leader in biodegradation. This award recognizes distinguished achievement in research and development in applied and environmental microbiology. (Source: EurekAlert! - Biology)

Fear of Pain as a Prognostic Factor in Chronic Pain: Conceptual Models, Assessment, and Treatment Implications

Current Pain and Headache Reports — Wed, 03 Mar 2010 08:07:53 +0100

This article summarizes current understanding of the role of pain-related fear in the onset of acute pain incidents, the transition of acute pain to chronic, and the pain severity and disability of patients with ongoing chronic pain conditions. Treatments demonstrated to reduce pain-related fear are presented, evidence demonstrating their efficacy at reducing disability and pain severity are summarized, and recent criticisms of the fear-avoidance model and future directions are considered. Content Type Journal ArticleDOI 10.1007/s11916-010-0094-xAuthors Dennis C. Turk, University of Washington Department of Anesthesiology & Pain Medicine Box 356540 Seattle WA 98195 USAHilary D. Wilson, University of Washington Department of Anesthesiology & Pain Medicine Box 356540 Seattle WA 98...

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Transcranial Doppler Ultrasound CO2 Challenge Complicated by Subarachnoid Hemorrhage in Patient with Moyamoya Syndrome

Neurocritical Care — Wed, 03 Mar 2010 08:07:19 +0100

Conclusion SAH has not previously been described as a complication of CO2 challenge in patients with moyamoya syndrome. While such complications are rare, it is important to consider the possibility of harm related to VMR testing in patients with advanced vasculopathy. Content Type Journal ArticleCategory Practical PearlDOI 10.1007/s12028-009-9314-9Authors Megan M. Donohue, University of Washington School of Medicine Department of Neurology, Harborview Medical Center Seattle USAAnne Moore, University of Washington School of Medicine Department of Neurological Surgery, Harborview Medical Center Seattle USADean Shibata, University of Washington School of Medicine Department of Radiology, Harborview Medical Center Seattle USAStephanie Ebel-Caswell, University of Washing...

Glaxo Birth Defect Litigation Reveals Paxil Promoters on Speed Dial

NaturalNews.com — Wed, 03 Mar 2010 07:00:00 +0100

(NaturalNews) In the first Paxil birth defect trial against GlaxoSmithKline, much of evidence focused on the doctors on Glaxo's payroll involved in the corruption of the medical literature and seminars given to promote the off label use of Paxil with pregnant and nursing mothers.On October 13, 2009, the trial of Kilker v Glaxo ended with a Philadelphia jury awarding $2.5 million in compensatory damages to the family of Lyam Kilker, after finding that Glaxo "negligently failed to warn" the doctor treating Lyam's mother about the risks of Paxil and the drug was a "factual cause" of the child's heart defects.Glaxo's lead attorney at trial was King and Spalding partner Chilton Varner, and the family's lead attorney was Sean Tracey from Houston.During his opening statement on September 15, 2009...

Dr. Hunter Handsfield wins prestigious Thomas Parran Award

EurekAlert! - Social and Behavioral Science — Wed, 03 Mar 2010 05:00:00 +0100

(University of Washington - Health Sciences/UW News, Community Relations & Marketing) University of Washington's Dr. H. Hunter Handsfield, a long-time trailblazer in sexually transmitted diseases (STD) research, will receive the nation's highest honor in the STD field during the Centers for Disease Control and Prevention's 2010 National STD Prevention Conference in Atlanta, March 8-11.Handsfield is the 2010 recipient of the Thomas Parran Award, named for Dr. Thomas Parran, Jr., U.S. Surgeon General from 1936 to 1948 and the chief developer of modern STD prevention strategies. (Source: EurekAlert! - Social and Behavioral Science)

Rendezvous: Scanner Tips and Tricks

Dragonfly — Tue, 02 Mar 2010 22:53:52 +0100

Are you interesting in improving your document delivery service through better performance by your scanner? Don’t miss this informative session. Join our free RML Rendezvous webcast on Wednesday, March 10th, 2010 at 1pm Pacific Time (2pm Mountain, noon Alaska) at https://webmeeting.nih.gov/rendezvous: Not Through a Glass, Darkly: Tips and Tricks for Optimal Scanner Settings by Mary Van Court, Library Supervisor at the University of Washington Health Sciences Library. As part of our Federal agency services regarding electronic and information technology resources being accessible to people with disabilities, closed captioning is now available on this and all future RML Rendezvouswebcasts. If you are hearing impaired and in need of closed captioning, please contact Patricia Devin...

Why Old Habits Die Hard: What Managers Need To Know

Psychology Today Work Center — Tue, 02 Mar 2010 16:26:10 +0100

Managers have been known to tear their hair out in frustration of why employees can't change behaviors, and discard old habits. Recent brain research gives us more accurate reasons as to why and what managers need to do about it. The bottom line is that you can't force anyone to change. Any kind of pressure will produce more resistance and could end up being counterproductive. Habits help us do everything, every day. Our unconscious mind eliminates the need for us to think consciously about each small step and action involved in everything from making a latte to operating the photocopier. Our mind wants to make a memory and make the thinking and behavior automatic so our conscious mind can deal with more immediate and complex things. That's the good news. The bad news is that habits can al...

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Medical Appropriateness of Imaging Referrals Analyzed

Modern Medicine — Tue, 02 Mar 2010 00:00:00 +0100

A quarter of the primary care physician referrals for medical imaging received by the University of Washington/Harborview Medical Center do not meet evidence-based appropriateness criteria, according to a study in the March issue of the Journal of the American College of Radiology. (Source: Modern Medicine)

Clinical Trial Participation Alone May Not Be Associated With Improved Outcomes For Childhood Cancer Patients

Health News from Medical News Today — Mon, 01 Mar 2010 23:00:00 +0100

Children with the most common childhood cancer did not experience improved outcomes from participating in a clinical trial between 1997 and 2005. Carl Koschmann, M.D., and colleagues at the University of Washington and Seattle Children's Hospital studied 322 patients with newly diagnosed acute lymphoblastic leukemia (a cancer involving the white blood cells), approximately half of whom participated in one of several available clinical trial protocols for the disease... (Source: Health News from Medical News Today)

Type 2 diabetes mellitus and the risk of sudden cardiac arrest in the community

Reviews in Endocrine & Metabolic Disorders — Mon, 01 Mar 2010 18:11:49 +0100

In this report, we review the absolute and relative risk of SCA associated with diabetes. We summarize recent evidence that suggests that the increase in risk in patients with diabetes is not specific for SCA, as diabetes also is associated with a similar increase in risk for non-SCA CHD death and non-fatal myocardial infarction. These data are consistent with prior observations that coronary atherosclerosis is a major contributor to the increased SCA risk associated with diabetes. We also present previously published and unpublished data that demonstrates that both clinically-recognized microvascular and autonomic neuropathy also are associated with the risk of SCA among treated patients with diabetes, after taking into account prior clinically-recognized heart disease and other ris...

Randomized Controlled Trial Demonstrates that Exposure to Mercury from Dental Amalgam Does Not Adversely Affect Neurological Development in Children

The Journal of Evidence-Based Dental Practice — Mon, 01 Mar 2010 00:00:00 +0100

Article Title and Bibliographic Information: Neurological outcomes in children with and without amalgam-related mercury exposure: seven years of longitudinal observations in a randomized trial.Lauterbach M, Martins IP, Castro-Caldas A, Bernardo M, Luis H, Amaral H, et al.J Am Dent Assoc 2008;139(2):138-45.Reviewer: J. Rodway Mackert, Jr., DMD, PhDPurpose/Question: The purpose of this study was to determine whether dental restoration with amalgam has a deleterious effect on neurological development.Source of Funding: Government: This project was funded by the National Institute of Dental and Craniofacial Research Cooperative Agreement grant U01 DE11894. Additional funding was provided by Center grant P30ES07033 and by Superfund Program Project grant P42ES04696 to the University of Washingt...

Kinex Pharmaceuticals Initiates A Phase 2 Clinical Trial Of KX2-391 In Patients With Prostate Cancer

Health News from Medical News Today — Fri, 26 Feb 2010 12:00:00 +0100

Kinex Pharmaceuticals opened a Phase 2 clinical trial to evaluate the safety and efficacy of KX2-391 in patients with bone-metastatic, castrate-resistant prostate cancer (CRPC) who have not had prior chemotherapy. The study will take place at the University of Chicago, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, the University of Wisconsin (Madison), the University of Washington (Seattle) and at Wayne State University. The lead Principal Investigator for the study is Dr. Michael Carducci from Johns Hopkins University... (Source: Health News from Medical News Today)

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US health care reform: a work in progress

The European Journal of Health Economics — Fri, 26 Feb 2010 09:42:50 +0100

Content Type Journal ArticleCategory EditorialDOI 10.1007/s10198-010-0225-7Authors Sean D. Sullivan, University of Washington Pharmaceutical Outcomes Research and Policy Program Seattle WA 98195 USA Journal The European Journal of Health EconomicsOnline ISSN 1618-7601Print ISSN 1618-7598 (Source: The European Journal of Health Economics)

Why the Wait? Delayed HIV Diagnosis among Men Who Have Sex with Men

Journal of Urban Health — Fri, 26 Feb 2010 06:46:43 +0100

Abstract We sought to identify factors associated with delayed diagnosis of human immunodeficiency virus (HIV; testing HIV-seropositive 6 months or more after HIV seroconversion), by comparing delayed testers to non-delayed testers (persons who were diagnosed within 6 months of HIV seroconversion), in King County, Washington among men who have sex with men (MSM). Participants were recruited from HIV testing sites in the Seattle area. Delayed testing status was determined by the Serologic Testing Algorithm for Recent HIV Seroconversion or a self-reported previous HIV-negative test. Quantitative data on sociodemographic characteristics, health history, and drug-use and sexual behaviors were collected via computer-assisted self-interviews. Qualitative semi-structured...

The Relationship Between Outpatient Mental Health Treatment and Subsequent Mental Health Symptoms and Disorders in Young Adults

Administration and Policy in Mental Health and Mental Health Services Research — Fri, 26 Feb 2010 06:46:12 +0100

The objective of this study was to evaluate community-based outpatient mental health services for young adults. Participants were interviewed at ages 21, 24, 27, and 30. Outcomes included: (1) symptoms of depression, generalized anxiety, social phobia, dysthymia and post traumatic stress individually and as a global scale; and (2) a dichotomous diagnosis variable inclusive of all above disorders. Treatment was indicated by an outpatient visit to a psychiatrist or other professional. Treatment did not reduce mental disorder or symptoms. Substance use, violence, poverty, community disorganization, and family history of antisocial behavior increased risks for negative outcomes, while social support was protective. The absence of positive findings associated with outpatient treatment is ...

Depression in Relation to Long-term Control of Glycemia, Blood Pressure, and Lipids in Patients with Diabetes

Journal of General Internal Medicine — Thu, 25 Feb 2010 08:01:54 +0100

Conclusions The adverse effect of depression on outcomes in patients with diabetes may not be mediated in large part by poorer glycemic, blood pressure, or lipid control. Further study is needed of the biologic effects of depression on patients with diabetes and their relation to adverse outcomes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11606-010-1272-6Authors Susan R. Heckbert, University of Washington Department of Epidemiology Seattle WA USACarolyn M. Rutter, Group Health Research Institute Biostatistics Unit Seattle WA USAMalia Oliver, Group Health Cooperative Group Health Research Institute Seattle WA USALisa H. Williams, University of Washington Department of Medicine (Dermatology) Seattle WA USAPaul Ciechanowski, University of Washin...

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

Diabetologia — Thu, 25 Feb 2010 06:46:42 +0100

Abstract Type 2 diabetes is a progressive disease characterised by islet amyloid deposits in the majority of patients. Amyloid formation is considered a significant factor in deterioration of islet function and reduction in beta cell mass, and involves aggregation of monomers of the normally soluble beta cell peptide, human islet amyloid polypeptide (hIAPP) into oligomers, fibrils and, ultimately, mature amyloid deposits. Despite extensive in vitro studies, the process of hIAPP aggregation in vivo is poorly understood, though it is widely reported to promote cytotoxicity. Recently, studies have suggested that only the early stages of fibril assembly, and in particular small hIAPP oligomers, are responsible for beta cell cytotoxicity. This challenges the prior concept that ...

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Congratulations, Linda Milgrom!

Dragonfly — Thu, 25 Feb 2010 01:29:34 +0100

As many know, Linda Milgrom, the RML’s Outreach Coordinator will be retiring on March 1, 2010. To celebrate her long-lived and wonderful career, we gave her a party. Guests included former RML and HSLers, as well as her family (even from faraway Washington DC!). It was a festive occasion, complete with a kazoo serenade to send her off in Italian style (think: That’s Amore!). Check out photos from the party on flickr. Reflecting on my years with Linda, as I think about her role in the RML, I think of: A Very Friendly, Open, and Generous *People* Person. Linda instantly finds ways to connect with whomever she meets… when she’s exhibiting, attending conferences, answering questions over the phone, making connections at the UW, and throughout the region. Through these conn...

Doubling Of Childhood Leukemia Rates In Southern Iraq Confirmed By International Study

Health News from Medical News Today — Mon, 22 Feb 2010 08:00:00 +0100

Childhood leukemia rates have more than doubled over the last 15 years in the southern Iraq province of Basrah, according to the study, "Trends in Childhood Leukaemia in Basrah, Iraq (1993-2007), published in the American Journal of Public Health. The authors, three of whom are from the University of Washington, say they hope their calculations can now pave the way for an investigation into reasons why the rates have climbed so high, and why they are higher than found in nearby Kuwait, or in the European Union or the United States... (Source: Health News from Medical News Today)

Serious birth defects linked to the agricultural chemical atrazine

NaturalNews.com — Mon, 22 Feb 2010 07:00:00 +0100

(NaturalNews) Gastroschisis is a birth defect in which the intestines, and sometimes other organs, develop outside the fetal abdomen and poke out through an opening in the abdominal wall. Long considered a rare occurrence, gastroschisis has mysteriously been on the rise over the last three decades. In fact, the incidence of the defect has soared, increasing two to four times in the last 30 years. But why?Researchers think they've found the answer. The culprit behind the suffering of babies born with this condition appears to be the agricultural chemical atrazine. That's the conclusion of a study just presented at the annual meeting of the Society for Maternal-Fetal Medicine (SMFM) held in Chicago. Researchers at the University of Washington in Seattle were alerted to a higher than normal n...

Earthquake engineers release report on damage in Haiti

EurekAlert! - Biology — Mon, 22 Feb 2010 05:00:00 +0100

(University of Washington) A UW engineer led a team of experts sent to Haiti to evaluate the impact of the magnitude-7 earthquake. The team's report to the US Geological Survey and the Earthquake Engineering Research Institute finds no surface evidence of the fault, but widespread damage caused by poor building practices. (Source: EurekAlert! - Biology)

Primary Care Physicians’ Attitudes Regarding Race-Based Therapies

Journal of General Internal Medicine — Sat, 20 Feb 2010 06:57:04 +0100

Conclusions Primary care physicians’ opinions regarding race-based therapy reveal a nuanced understanding of race-based therapies and a wariness of their use by physicians. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s11606-009-1190-7Authors Danielle Frank, Ambulatory Care 11A (152); VA Ann Arbor Healthcare System 2215 Fuller Road Ann Arbor MI 48105 USAThomas H. Gallagher, University of Washington Department of Medicine Seattle WA USASherrill L. Sellers, University of Wisconsin School of Social Work Madison WI USALisa A. Cooper, Johns Hopkins University School of Medicine Department of Medicine Baltimore MD USAEboni G. Price, Tulane University Department of Medicine New Orleans LA USAAdebola O. Odunlami, Harvard University School of Public Health B...

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Local social dynamics key to success of tropical marine conservation areas

EurekAlert! - Social and Behavioral Science — Fri, 19 Feb 2010 05:00:00 +0100

(University of Washington) As biologists and ecologists propose ever-larger conservation areas in the tropics, ones that encompass multiple countries, social scientists say it's local people banding together with their community leaders who ultimately determine the success or failure of such efforts in many parts of the world. (Source: EurekAlert! - Social and Behavioral Science)

The COSMIN checklist for assessing the methodological quality of studies on measurement properties of health status measurement instruments: an international Delphi study

Quality of Life Research — Thu, 18 Feb 2010 17:57:13 +0100

Conclusions The resulting COSMIN checklist could be useful when selecting a measurement instrument, peer-reviewing a manuscript, designing or reporting a study on measurement properties, or for educational purposes. Content Type Journal ArticleDOI 10.1007/s11136-010-9606-8Authors Lidwine B. Mokkink, VU University Medical Center Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research Van der Boechorststraat 7 1081 BT Amsterdam The NetherlandsCaroline B. Terwee, VU University Medical Center Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research Van der Boechorststraat 7 1081 BT Amsterdam The NetherlandsDonald L. Patrick, University of Washington Department of Health Services Thur Canal S...

International study confirms doubling of childhood leukemia rates in southern Iraq

EurekAlert! - Cancer — Thu, 18 Feb 2010 05:00:00 +0100

(University of Washington - Health Sciences/UW News, Community Relations & Marketing) Childhood leukemia rates have more than doubled over the last 15 years in the southern Iraq province of Basrah, according to the study, "Trends in Childhood Leukemia in Basrah, Iraq (1993-2007), published in the American Journal of Public Health. The authors, three of whom are from the University of Washington, say they hope their calculations can now pave the way for an investigation into reasons why the rates have climbed so high. (Source: EurekAlert! - Cancer)

Research Suggests Herpes Drug May Help Fight HIV

About AIDS / HIV — Thu, 18 Feb 2010 00:00:00 +0100

There is new research that suggests that people infected with both HIV and Herpes Simplex type 2 may benefit more than expected from taking the anti-herpes drug Acyclovir. In addition to treating the herpes, studies now provide evidence that the drug also slows the progression of HIV in people living with both viruses. The study, co-authored by Dr. Jairam Lingappa, of the University of Washington, showed a 16% decline in HIV progression in those people taking Acyclovir for their herpes. Experts remind us that HIV specific medications do a far better job of slowing HIV than does Acyclovir but suggested that the anti-herpes medication could be useful in those people who have not progressed so far that they need HIV medication. Related Herpes Information Understanding Genital Herpes A...

Supporting Cell Division Is Not Required for Regeneration of Auditory Hair Cells After Ototoxic Injury In Vitro

JARO - Journal of the Association for Research in Otolaryngology — Wed, 17 Feb 2010 18:30:28 +0100

In this study, we characterized an organ culture model to study auditory hair cell regeneration, and we used these cultures to test if direct transdifferentiation alone can lead to significant hair cell regeneration. Control cultures (organs from posthatch chickens maintained without streptomycin) showed complete hair cell loss in the proximal (high-frequency) region by 5 days. In contrast, a 2-day treatment with streptomycin induced loss of hair cells from all regions by 3 days. Hair cell regeneration proceeded in culture, with the time course of supporting cell division and hair cell differentiation generally resembling in vivo patterns. The degree of supporting cell division depended upon the presence of streptomycin, the epithelial region, the type of culture media, an...

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Flexible flatfoot in children and adolescents

Journal of Children's Orthopaedics — Wed, 17 Feb 2010 17:58:17 +0100

Abstract Flexible flatfoot is a normal foot shape that is present in most infants and many adults. The arch elevates spontaneously in most children during the first decade of life. There is no evidence that a longitudinal arch can be created in a child’s foot by any external forces or devices. Flexible flatfoot with a short Achilles tendon, in contrast to simple flexible flatfoot, is known to cause pain and disability in some adolescents and adults. Joint-preserving, deformity-correcting surgery is indicated in flexible flatfeet with short Achilles tendons when conservative measurements fail to relieve pain under the head of the plantar flexed talus or in the sinus tarsi area. Osteotomy is the fundamental and central procedure of choice. In almost all cases, Achilles ten...

Brain-Controlled Cursor Doubles As A Neural Workout

Health News from Medical News Today — Tue, 16 Feb 2010 10:00:00 +0100

Harnessing brain signals to control keyboards, robots or prosthetic devices is an active area of medical research. Now a rare peek at a human brain hooked up to a computer shows that the two can adapt to each other quickly, and possibly to the brain's benefit. Researchers at the University of Washington looked at signals on the brain's surface while using imagined movements to control a cursor... (Source: Health News from Medical News Today)

Brain-Controlled Cursor Doubles As A Neural Workout

IT / Internet / E-mail News From Medical News Today — Tue, 16 Feb 2010 10:00:00 +0100

Population description and its role in the interpretation of genetic association

Human Genetics — Mon, 15 Feb 2010 17:59:48 +0100

Abstract Despite calls for greater clarity and precision of population description, studies have documented persistent ambiguity in the use of race/ethnicity terms in genetic research. It is unclear why investigators tolerate such ambiguity, or what effect these practices have on the evaluation of reported associations. To explore the way that population description is used to replicate and/or extend previously reported genetic observations, we examined articles describing the association of the peroxisome proliferator-activated receptor-gamma-γ Pro12Ala polymorphism with type 2 diabetes mellitus and related phenotypes, published between 1997 and 2005. The 80 articles identified were subjected to a detailed content analysis to determine (1) how sampled populations were des...

Treatment For Herpes Could Delay HIV Disease Progression In Patients Infected With Both Herpes And HIV

Health News from Medical News Today — Mon, 15 Feb 2010 08:00:00 +0100

An article published Online First and in an upcoming edition of The Lancet reports that recent research indicates that aciclovir, used to treat HSV2, could delay HIV-1 disease progression in patients co-infected with both conditions. In most cases, people who are infected with HIV-1 are dually infected with herpes simplex virus type 2 (HSV2). The article is the work of Dr Jairam Lingappa, University of Washington, Seattle, WA, USA, and colleagues in Africa and internationally. It is established that daily suppression of the herpes virus reduces plasma HIV-1 concentrations... (Source: Health News from Medical News Today)

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Brain-controlled cursor doubles as a neural workout

EurekAlert! - Social and Behavioral Science — Mon, 15 Feb 2010 05:00:00 +0100

(University of Washington) Electrodes on the surface of the brain show that using imagined movements to control a computer cursor can generate larger-than-life brain signals after less than 10 minutes of training. (Source: EurekAlert! - Social and Behavioral Science)

Maternal Morbidity and Perinatal Outcomes Among Foreign-Born Cambodian, Laotian, and Vietnamese Americans in Washington State, 1993–2006

Journal of Immigrant and Minority Health — Sun, 14 Feb 2010 06:51:51 +0100

This study examined differences in perinatal outcomes of Southeast Asian (SEA) women compared with non-Hispanic white women in Washington. Using linked birth certificate and hospitalization discharge records for the years 1993–2006, we compared singleton births of Cambodian (3,858), Laotian (2,223), and Vietnamese (12,949) women with a random sample of white women (35,581). Associations between maternal nativity and perinatal outcomes were assessed using multivariable logistic regression. There are clear nativity differences among SEAs for gestational diabetes mellitus, anemia, placenta previa and febrile illness. SEAs had increased risks for these disorders when compared with white women. Compared with infants delivered of white women, infants of SEAs had increased risks for moder...

The use of the three-pronged Mayfield head clamp resulting in an intracranial epidural hematoma in an adult patient

European Spine Journal — Sun, 14 Feb 2010 06:50:31 +0100

We report the occurrence of an intracranial epidural hematoma in an adult patient without any prior intracranial pathology after the use of a Mayfield head clamp during posterior cervical spine surgery. The purpose of the study was to report an occurrence of epidural hematoma from the use of a Mayfield head clamp in an adult patient and to review the literature. The diagnosis of intracranial epidural hematoma should be considered in the presence of persistent headache and nausea after the use of a head clamp in spinal or intracranial surgery. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00586-010-1323-zAuthors Michael J. Lee, University of Washington Medical Center Department of Orthopaedics and Sports Medicine 1959 Pacific St NE Box 356500 Seattle WA 98159 USAEric...

How analyzing your problems may be counterproductive

Psychology Today Work Center — Sat, 13 Feb 2010 18:39:33 +0100

When you're upset or depressed, should you analyze your feelings to figure out what's wrong? Or should you just forget about it and move on? New research and theories suggests if you do want to think about your problems, do so from a detached perspective, rather than reliving the experience.This answer is related to a psychological paradox: Processing emotions is supposed to help you facilitate coping, but attempts to understand painful feelings often backfire and perpetuate or strengthen negative moods and emotions. The solution seems to be neither denial or distraction, according to research conducted by University of Michigan psychologist Ethan Kross, who says the best way to move forward emotionally is to examine one's feelings from a distance or detached perspective.Kross, along with ...

A Twin Study of Sleep Duration and Body Mass Index

Journal of Clinical Sleep Medicine : JCSM — Sat, 13 Feb 2010 16:23:47 +0100

Conclusions: Short sleep was associated with elevated BMI following careful adjustment for genetics and shared environment. These findings point toward an environmental cause of the relationship between sleep duration and BMI. Keywords: Sleep duration, obesity, twins, monozygotic, dizygotic, body mass index (Source: Journal of Clinical Sleep Medicine : JCSM)

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New Book Suggests Workplace Gendered Tradeoffs Lead To Economic Inequalities For Women

Health News from Medical News Today — Sat, 13 Feb 2010 08:00:00 +0100

Despite big changes over recent decades, workplace gender inequalities endure in the United States and other industrialized nations around the world. These inequalities are created by facets of national social policy that either ease or concentrate the demands of care giving within households and shape expectations in the workplace, according to University of Washington sociologists... (Source: Health News from Medical News Today)

New Book Suggests Workplace Gendered Tradeoffs Lead To Economic Inequalities For Women

Women's Health / OBGYN News From Medical News Today — Sat, 13 Feb 2010 08:00:00 +0100

For a Psychological Lift on Valentine’s Day: Watch Up

Psychology Today Relationships Center — Fri, 12 Feb 2010 22:59:09 +0100

The main character in Up is Carl Fredericksen - a 78 year old retired balloon salesman. Carl shares a key feature with George Clooney's character in Up in the Air - both men spend a good portion of the movie flying above the clouds. And both movies take interesting twists on the classical evolutionary themes of Getting the Girl and Getting Along. But the similarities end there.If you were going to pick a flick to watch on Valentine's Day, you might be inclined to watch something like Up in the Air, which is an adult story starring the handsome George Clooney and the beautiful Vera Farmiga. But unless you're hopelessly jaded, we're pretty sure you'd be a lot more uplifted if you picked the cartoon.Attachment versus DetachmentAs we noted in our last review, Up in the Air is about a man who r...

Update in Medical Education

Journal of General Internal Medicine — Fri, 12 Feb 2010 07:31:19 +0100

Content Type Journal ArticleCategory UpdatesDOI 10.1007/s11606-009-1244-xAuthors Carol K. Bates, Beth Israel Deaconess Medical Center Division of General Medicine and Primary Care Boston MA USAShobhina G. Chheda, University of Wisconsin School of Medicine and Public Health Department of Medicine, Section of General Internal Medicine Madison WI USAKathel Dunn, National Library of Medicine Bethesda MD USALinda Pinsky, University of Washington School of Medicine Seattle WA USAReena Karani, Mount Sinai School of Medicine Brookdale Department of Geriatrics, Samuel M. Bronfman Department of Medicine, Department of Medical Education New York NY USA Journal Journal of General Internal MedicineOnline ISSN 1525-1497Print ISSN 0884-8734 (Source: Journal of General Internal Medicine)

What managers need to know about decision-making

Psychology Today Work Center — Thu, 11 Feb 2010 20:05:57 +0100

This study showed that unconscious predictive brain activity comes first and the conscious experience follows. Dean Sibata of the University of Washington reported in his study of brain functioning that when people make decisions that affect their lives, they would use the emotional parts of the brain as the driver, even though the task may not seem emotional.These findings fly in the face of conventional management "scientific" theories of the past, which have argued for only one kind of thought process to support decision-making--logical, rational, analytical thinking in the conscious mind--totally ignoring our unconscious, emotional mind.The implications of this research are significant for individuals in the personal lives and for organizations, particularly leadership behavior. It can...

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Radical new directions needed in food production to deal with climate change

EurekAlert! - Medicine and Health — Thu, 11 Feb 2010 05:00:00 +0100

(University of Washington) An international panel of scientists is urging dramatically changed ideas about sustainable agriculture to prevent a major starvation catastrophe by the end of this century among more than 3 billion people who live in the tropics. (Source: EurekAlert! - Medicine and Health)

Workplace gendered tradeoffs lead to economic inequalities for women

EurekAlert! - Social and Behavioral Science — Thu, 11 Feb 2010 05:00:00 +0100

(University of Washington) Workplace equality for women boils down to not only whether women are included in the workforce but on how they are included. (Source: EurekAlert! - Social and Behavioral Science)

EthnoMed Transformation

Dragonfly — Thu, 11 Feb 2010 00:39:06 +0100

UW HSLIC Acting Director Neil Rambo introducing the EthnoMed team. Photo by Josh Malamy. Congratulations to the EthnoMed team at Harborview Medical Center and the University of Washington Health Sciences Library on the unveiling of its redesigned website. EthnoMed: http://ethnomed.org/ EthnoMed debuted in 1994 as a collaboratively developed online resource for cultural health information. The redesigned site has enhanced content, display, and navigation features. Behind the scenes is a Plone-based content management system which will allow for faster updates and editing. The site also features a new, prize-winning logo. EthnoMed “contains information about cultural beliefs, medical issues and related topics pertinent to the health care of immigrants to Seattle or the US, many of whom...

Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost

Diabetologia — Wed, 10 Feb 2010 06:47:26 +0100

Conclusions/interpretation Among diabetic patients hospitalised with SSTI from 2003 to 2007, only MRSA increased in prevalence. Patients with non-foot (vs foot) infections were more severely ill. Independent risk factors for increased mortality rates, length of stay and costs included more severe illness, transfer from another hospital and wound cultures with Pseudomonas or other gram-negatives. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1672-5Authors B. A. Lipsky, University of Washington VA Puget Sound Health Care System, General Internal Medicine (S-111-PCC) 1660 S. Columbian Way Seattle WA USAY. P. Tabak, CareFusion Clinical Research Marlborough MA USAR. S. Johannes, CareFusion Clinical Research Marlborough MA USAL. Vo, Ortho-McNeil Janssen...

Adapting to clogged airways makes common pathogen resist powerful drugs

EurekAlert! - Medicine and Health — Tue, 09 Feb 2010 05:00:00 +0100

(University of Washington) Mutations of a common environmental pathogen that causes chronic lung disease in patients with cystic fibrosis are able to survive in oxygen-poor, nitrate-rich airway secretions. This same survival mechanism also enables the mutate bacteria to resist the effects of certain antibiotics -- even without any previous exposure to antibiotics. (Source: EurekAlert! - Medicine and Health)

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Big Think: Why ET never calls

The Independent - Science — Mon, 08 Feb 2010 17:56:07 +0100

Peter Ward, paleontologist at the University of Washington, on how our inability to detect other life in the universe may stem from interstellar communication problems. Then again, it may be because Earth evolution is “like Mr. Bean.” (Source: The Independent - Science)

Undergraduate Summer Research Program in Genomics

ScanGrants feed — Mon, 08 Feb 2010 00:00:00 +0100

The UW GenOM Project offers a summer research experience in genomics to talented students and strongly encourages those from underrepresented minority groups (i.e., African Americans, Hispanic Americans, Native Americans, Alaskan Natives, Native Hawaiians, Filipino/a Americans, and Pacific Islanders) to apply. PARTICIPANTS WILL: • be provided first-hand, quality experiences in laboratories of established researchers; • explore the rapidly expanding field of genomics; • gain the confidence and academic exposure to prepare for graduate/professional level programs; and • join a network of advisors, researchers, professors, staff, and support programs for students of color. COMPENSATIONS: STUDENT WAGES AND TRAVEL Students in the program may receive either a salary or a st...

Research Experience for Undergraduates in Genetically Engineered Materials Science and Engineering Summer 2010

ScanGrants feed — Mon, 08 Feb 2010 00:00:00 +0100

The Genetically Engineered Materials Science and Engineering Center (GEMSEC) at the University of Washington will host a Research Experience for Undergraduates (REU) Program from June 14th through August 20th, 2010. Engineering and science students with broad interests across disciplines focusing on biomimetics, materials science, or nanotechnology are eligible to apply. Participants in this ten-week program will be actively involved in hands-on scientific research with broad applications - e.g., bio-engineering, chemistry, electronics, materials science, optics, optoelectronics, physics, and the life sciences. Research projects will be designed and supervised by faculty members and interns will also work closely with graduate students, postdoctoral fellows, and technical staff on projec...

Injection volumes of dextranomer/hyaluronic acid are increasing in the endoscopic management of vesicoureteral reflux

Pediatric Surgery International — Sat, 06 Feb 2010 17:59:37 +0100

Conclusion Over the study period there was an increase in the number of vials of dextranomer/hyaluronic acid being used per patient to treat children with VUR. This practice may improve success rates but will increase the cost of treatment due to the inherent expense of the material. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-010-2558-9Authors Mathew D. Sorensen, University of Washington School of Medicine Department of Urology 1959 NE Pacific Street Box 356510 Seattle WA 98195 USAMartin A. Koyle, Seattle Children’s Hospital and Regional Medical Center, University of Washington School of Medicine Division of Pediatric Urology, Department of Urology Seattle WA 98105 USACharles A. Cowan, Seattle Children’s Hospital and Regional Medical C...

Andrew Wakefield, Scientific Censorship, and Fourteen Monkeys; A statement by Jenny McCarthy and Jim Carrey

NaturalNews.com — Sat, 06 Feb 2010 07:00:00 +0100

(NaturalNews) When it comes to vaccines, Jenny McCarthy and Jim Carrey get it. They see how the pharma industry is engineering a campaign to silence Dr. Andrew Wakefield in order to suppress the publication of startling new evidence linking vaccines to severe neurological damage.At great risk to their professional careers, Jenny McCarthy and Jim Carrey have found the courage to dare to tell the truth about vaccines and autism. Despite the vicious attacks by the pro-vaccine zealots who will stop at nothing to destroy anyone who challenges conventional vaccine mythology, McCarthy and Carrey have issued a powerful, inspired statement that reveals the truth behind the Big Pharma smear campaign that is intent on destroying the reputation of Dr. Andrew Wakefield before he can publish the final r...

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HLA-A2-restricted T-cell epitopes specific for prostatic acid phosphatase

Cancer Immunology, Immunotherapy — Fri, 05 Feb 2010 17:53:00 +0100

Abstract Prostatic acid phosphatase (PAP) has been investigated as the target of several antigen-specific anti-prostate tumor vaccines. The goal of antigen-specific active immunotherapies targeting PAP would ideally be to elicit PAP-specific CD8+ effector T cells. The identification of PAP-specific CD8+ T-cell epitopes should provide a means of monitoring the immunological efficacy of vaccines targeting PAP, and these epitopes might themselves be developed as vaccine antigens. In the current report, we hypothesized that PAP-specific epitopes might be identified by direct identification of pre-existing CD8+ T cells specific for HLA-A2-restricted peptides derived from PAP in the blood of HLA-A2-expressing individuals. 11 nonamer peptides derived from the amino acid sequence ...

Assessing the prospects of genome-wide association studies performed in inbred mice

Mammalian Genome — Thu, 04 Feb 2010 18:09:40 +0100

Abstract The remarkable success in mapping genes linked to a number of disease traits using genome-wide association studies (GWAS) in human cohorts has renewed interest in applying this same technique in model organisms such as inbred laboratory mice. Unlike humans, however, the limited genetic diversity in the ancestry of laboratory mice combined with selection pressure over the past decades have yielded an intricate population genetic structure that can complicate the results obtained from association studies. This problem is further exacerbated by the small number of strains typically used in such studies where multiple spurious associations arise as a result of random chance. We sought to empirically assess the viability of GWAS in inbred mice using hundreds of express...

Infected thyroglossal duct cyst

Pediatric Radiology — Thu, 04 Feb 2010 18:09:13 +0100

Content Type Journal ArticleCategory Clinical ImageDOI 10.1007/s00247-010-1563-4Authors Puneet Bhargava, University of Washington & VA Puget Sound Health Care System Department of Radiology Mailbox 358280 S-114/Radiology, 1660 S. Columbian Way Seattle WA 98108 USAMarguerite Parisi, University of Washington and Seattle Children’s Hospital Department of Radiology 4800 Sand Point Way NE, MS R-5417 Seattle WA 98105 USA Journal Pediatric RadiologyOnline ISSN 1432-1998Print ISSN 0301-0449 (Source: Pediatric Radiology)

Assessing the cost-effectiveness of drug and lifestyle intervention following opportunistic screening for pre-diabetes in primary care

Diabetologia — Thu, 04 Feb 2010 18:08:18 +0100

Conclusions/interpretation Screening for pre-diabetes followed by diet and exercise, or metformin treatment is cost-effective and should be considered for incorporation into current practice. The number of dietitians and exercise physiologists needed to deliver such lifestyle change interventions will need to be increased to appropriately support the intervention. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-010-1661-8Authors M. Y. Bertram, The University of Queensland Centre for Burden of Disease and Cost-Effectiveness, School of Population Health Herston Rd Herston Queensland 4006 AustraliaS. S. Lim, The University of Washington Centre for Health Metrics and Evaluation Seattle WA USAJ. J. Barendregt, The University of Queensland Centre for Burden o...

Measurement and correlates of ano-genital distance in healthy, newborn infants

International Journal of Andrology — Thu, 04 Feb 2010 00:00:00 +0100

Ano-genital distance (AGD) is a sexually dimorphic trait that is a well established reproductive toxicity endpoint in animals. In male animals, a shortened AGD is associated with a variety of genital abnormalities including hypospadias and cryptorchidism. Consensus on the anatomical definition of AGD in humans remains to be established and few data exist on the determinants and normal variance in the general population. We implemented a standardized anthropometric protocol to measure AGD, ano-scrotal distance (ASD), and ano-fourchette distance (AFD) in 169 (82 male, 87 female) infants in the University of Washington newborn nursery in 2008. We collected data on the following characteristics: weight, length, and occipital head circumference, race and relevant gestational complications. Usin...

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DSM-V: an opportunity to embrace the future of psychiatric diagnosis

Archives of Women's Mental Health — Tue, 02 Feb 2010 18:52:27 +0100

Content Type Journal ArticleDOI 10.1007/s00737-009-0120-3Authors David R. Rubinow, University of North Carolina - Chapel Hill School of Medicine, UNC Department of Psychiatry Chapel Hill NC USAAlexandra Miller, University of North Carolina - Chapel Hill School of Medicine, UNC Department of Psychiatry Chapel Hill NC USAKatya B. Rubinow, University of Washington School of Medicine, University of Washington, UW Division of Endocrinology in the Department of Medicine Seattle WA USA Journal Archives of Women's Mental HealthOnline ISSN 1435-1102Print ISSN 1434-1816 Journal Volume Volume 13 Journal Issue Volume 13, Number 1 / February, 2010 (Source: Archives of Women's Mental Health)

A 48-year-old man with chronic right shoulder pain and weakness after a fall: diagnosis and discussion

Skeletal Radiology — Tue, 02 Feb 2010 17:46:44 +0100

Content Type Journal ArticleCategory Test Yourself: AnswerDOI 10.1007/s00256-009-0841-4Authors Matthew D. Epstein, University of Washington Department of Radiology 1959 NE Pacific Street Box 357115 Seattle WA 98195-7115 USAPuneet Bhargava, University of Washington Department of Radiology 1660 S Columbian Way, S-114/Radiology, Mail Stop 358280 Seattle WA 98108 USAJonathan R. Medverd, University of Washington Department of Radiology 1660 S Columbian Way, S-114/Radiology, Mail Stop 358280 Seattle WA 98108 USA Journal Skeletal RadiologyOnline ISSN 1432-2161Print ISSN 0364-2348 (Source: Skeletal Radiology)

Symptoms Poor Indicators Of Ovarian Cancer, Study Finds

Health News from Medical News Today — Tue, 02 Feb 2010 11:00:00 +0100

Only about 1% of women who experience symptoms of ovarian cancer, such as persistent bloating or pelvic pain, actually have the cancer, according to a study published Thursday in the Journal of the National Cancer Institute, Reuters reports. Lead author Mary Anne Rossing, an epidemiologist at the University of Washington, said, "What this (study) suggests is that it's going to be hard to move the diagnosis of ovarian cancer forward... (Source: Health News from Medical News Today)

3-D scaffold provides clean, biodegradable structure for stem cell growth

EurekAlert! - Medicine and Health — Tue, 02 Feb 2010 05:00:00 +0100

(University of Washington) A natural material derived from crustacean shell and algae supports the growth of human embryonic stem cells. (Source: EurekAlert! - Medicine and Health)

Cocaine, Spices, and Hormones Now Being Found in Drinking Water

NaturalNews.com — Mon, 01 Feb 2010 07:00:00 +0100

(NaturalNews) A University of Washington research team recently released the results of a study it conducted on contaminant residue in the waters of Puget Sound in Washington State. Various spices, flavorings and other substances are being identified as making their way out of water treatment plants and back into the world's water supply.Winter holidays like Thanksgiving and Christmas bring extra amounts of cinnamon while chocolate and vanilla are especially popular on the weekends. Likewise, caramel corn residue and waffle-cone pieces are particularly excessive around the Independence Day. The most popular contaminant found in the sound is artificial vanilla flavor which is found at an average of 14 milligrams per liter of water.Around the world, scientists are finding all sorts of things...

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Giant gastric bezoar presenting as an acute abdominal emergency

Pediatric Radiology — Mon, 01 Feb 2010 06:45:40 +0100

Content Type Journal ArticleCategory Clinical ImageDOI 10.1007/s00247-009-1511-3Authors Puneet Bhargava, University of Washington Department of Radiology Seattle WA USAGrace Phillips, University of Washington Department of Radiology Seattle WA USA Journal Pediatric RadiologyOnline ISSN 1432-1998Print ISSN 0301-0449 (Source: Pediatric Radiology)

Pulmonary pathology society lifetime achievement award, 2009: david dail, MD, virginia mason medical center, clinical professor of pathology, university of washington.

Archives of Pathology and Laboratory Medicine — Mon, 01 Feb 2010 00:00:00 +0100

Authors: Guinee DG PMID: 20121611 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

From Novice to Expert: Obstacles and Opportunities for Residency Programs

PM&R — Mon, 01 Feb 2010 00:00:00 +0100

Physical medicine and rehabilitation (PM&R) residency programs have a duty to the public to educate physicians who will practice competently and independently and to their residents to help them become lifelong learners who will maintain their expertise. In pursuit of these goals, residency programs and their directors are enabled, and at times impeded by, local resources and national regulatory requirements. Some of the challenges and changes facing residency programs and the field include the demographics of the trainees, the environment of teaching, the evolution toward fellowship training, and preparation for engaging in maintenance of certification (MOC). Although my experiences have been informed by my work as residency program director (PD) at the University of Washington, as a dire...

Introduction to SCAR 2000: The 17th Symposium for Computer Applications in Radiology: “The Electronic Practice: Radiology and the Enterprise”

Journal of Digital Imaging — Sat, 30 Jan 2010 18:17:56 +0100

Content Type Journal ArticleDOI 10.1007/BF03167611Authors Byrn Williamson, Mayo Clinic SCAR 2000 Program Committee RochesterNicholas Hangiandreou, Mayo Clinic SCAR 2000 Scientific Committee RochesterSteve Langer, University of Washington SCAR 2000 Scientific Committee Seattle Journal Journal of Digital ImagingOnline ISSN 1618-727XPrint ISSN 0897-1889 Journal Volume Volume 13 Journal Issue Volume 13, Supplement 1 / May, 2000 (Source: Journal of Digital Imaging)

Should Surgeons Warm Up Before Performing Surgery? New Study Investigates

Health News from Medical News Today — Fri, 29 Jan 2010 19:00:00 +0100

Basketball players, baseball pitchers, and athletes warm up before they perform, and now researchers in the US are investigating whether surgeons should do the same to ensure they are better prepared for when they have to perform. Dr Tom Lendvay, assistant professor in the Department of Urology at the University of Washington in Seattle thinks there could be something in this idea, and to this end the US Army Medical Research and Materiel Command has awarded him some funds to study the effect of pre-operative warm-up on virtual reality surgical task proficiency... (Source: Health News from Medical News Today)

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A 48-year-old man with chronic right shoulder pain and weakness after a fall

Skeletal Radiology — Fri, 29 Jan 2010 17:57:34 +0100

Content Type Journal ArticleCategory Test Yourself: QuestionDOI 10.1007/s00256-009-0846-zAuthors Matthew D. Epstein, University of Washington Department of Radiology 1959 NE Pacific Street Box 357115 Seattle WA 98195-7115 USAPuneet Bhargava, University of Washington & VA Puget Sound Health Care System Department of Radiology 1660 S Columbian Way, S-114/Radiology, Mail Stop 358280 Seattle WA 98108 USAJonathan R. Medverd, University of Washington & VA Puget Sound Health Care System Department of Radiology 1660 S Columbian Way, S-114/Radiology, Mail Stop 358280 Seattle WA 98108 USA Journal Skeletal RadiologyOnline ISSN 1432-2161Print ISSN 0364-2348 (Source: Skeletal Radiology)

Deletion of the Chd6 exon 12 affects motor coordination

Mammalian Genome — Thu, 28 Jan 2010 17:59:40 +0100

Abstract Members of the CHD protein family play key roles in gene regulation through ATP-dependent chromatin remodeling. This is facilitated by chromodomains that bind histone tails, and by the SWI2/SNF2-like ATPase/helicase domain that remodels chromatin by moving histones. Chd6 is ubiquitously expressed in both mouse and human, with the highest levels of expression in the brain. The Chd6 gene contains 37 exons, of which exons 12-19 encode the highly conserved ATPase domain. To determine the biological role of Chd6, we generated mouse lines with a deletion of exon 12. Chd6 without exon 12 is expressed at normal levels in mice, and Chd6 Exon 12 −/− mice are viable, fertile, and exhibit no obvious morphological or pathological phenotype. Chd6 Exon 12 −/− mice lack coor...

Comorbid Depression Is Associated with an Increased Risk of Dementia Diagnosis in Patients with Diabetes: A Prospective Cohort Study

Journal of General Internal Medicine — Thu, 28 Jan 2010 07:03:55 +0100

CONCLUSIONS Patients with major depression and diabetes had an increased risk of development of dementia compared to those with diabetes alone. These data add to recent findings showing that depression was associated with an increased risk of macrovascular and microvascular complications in patients with diabetes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11606-009-1248-6Authors Wayne J. Katon, University of Washington School of Medicine Department of Psychiatry & Behavioral Sciences 1959 NE Pacific Street Box 356560 Seattle WA 98195-6560 USAElizabeth H. B. Lin, Group Health Research Institute Seattle WA USALisa H. Williams, University of Washington School of Medicine Department of Medicine Seattle WA USAPaul Ciechanowski, University of Washin...

Antiretroviral Adherence Interventions: Translating Research Findings to the Real World Clinic

Current HIV/AIDS Reports — Wed, 27 Jan 2010 20:01:14 +0100

In conclusion, we consider implications and offer strategies for enhancing adherence in clinic-based HIV care prior to ART initiation, at initiation, and over the course of treatment. Content Type Journal ArticleDOI 10.1007/s11904-009-0037-5Authors Jane M. Simoni, University of Washington Department of Psychology Campus Box 351525 Seattle WA 98195-1525 USAK. Rivet Amico, University of Connecticut Center for Health, Intervention & Prevention 2006 Hillside Road Storrs CT 06269 USALaramie Smith, University of Connecticut Center for Health, Intervention & Prevention, Department of Psychology 2006 Hillside Road, Unit 1248 Storrs CT 06269 USAKimberly Nelson, University of Washington Department of Psychology Campus Box 351525 Seattle WA 98195-1525 USA Journal Current HIV/AIDS Repor...

Body size adjustments for left ventricular mass by cardiovascular magnetic resonance and their impact on left ventricular hypertrophy classification

The International Journal of Cardiovascular Imaging — Wed, 27 Jan 2010 19:55:48 +0100

Abstract Methods to index left ventricular (LV) mass, measured by cardiovascular magnetic resonance (CMR), for body size have not been investigated. The purposes of this study were to develop allometric indices for LV mass measured by CMR and compare estimates of the prevalence and predictive value of LV hypertrophy defined by a new allometric height-weight index, LV mass/body surface area (BSA), height indices (a new allometric height index; and previously derived indices from echocardiographic measurements: LV mass/height2, LV mass/height2.7), and non-indexed LV mass. 5,004 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) with CMR measurements of LV mass and no clinical cardiovascular disease at baseline were followed for a median of 4.1 years. The ...

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Severe complications of diabetes higher in depressed patients

EurekAlert! - Social and Behavioral Science — Wed, 27 Jan 2010 05:00:00 +0100

(University of Washington) A prospective study of Group Health primary-care patients with diabetes in western Washington showed that depression raised the risks of advanced and severe complications from diabetes during a five-year follow-up (Source: EurekAlert! - Social and Behavioral Science)

Scientists map changes in science and beyond

EurekAlert! - Medicine and Health — Wed, 27 Jan 2010 05:00:00 +0100

(Public Library of Science) How has the structure of scientific research changed over the past decade? A team of researchers from Umea University, Sweden, and the University of Washington aims to answer this question and others in a study published on January 27 in the online, open-access journal PLoS ONE. (Source: EurekAlert! - Medicine and Health)

Shedding New Light On Early Transmembrane Signaling

Health News from Medical News Today — Tue, 26 Jan 2010 12:00:00 +0100

Two new studies by researchers at the University of Washington further our understanding of the molecular steps in the PLC cascade, a G protein-coupled receptor signaling mechanism that underlies a wide variety of cellular processes, including egg fertilization, hormone secretion, and the regulation of certain potassium channels. The studies appear online January 25 in the Journal of General Physiology . Falkenburger et al... (Source: Health News from Medical News Today)

Shedding New Light On Early Transmembrane Signaling

Biology / Biochemistry News From Medical News Today — Tue, 26 Jan 2010 12:00:00 +0100

Two new studies by researchers at the University of Washington further our understanding of the molecular steps in the PLC cascade, a G protein-coupled receptor signaling mechanism that underlies a wide variety of cellular processes, including egg fertilization, hormone secretion, and the regulation of certain potassium channels... (Source: Biology / Biochemistry News From Medical News Today)

New formula helps gauge the winds of change

EurekAlert! - Social and Behavioral Science — Tue, 26 Jan 2010 05:00:00 +0100

(University of Washington) Researchers devise formula to examine just what types of change occur over time among complex and integrated structures. (Source: EurekAlert! - Social and Behavioral Science)

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Strategies to Achieve Target LDL Levels

Current Diabetes Reports — Mon, 25 Jan 2010 17:02:31 +0100

Content Type Journal ArticleCategory Clinical Trial ReportDOI 10.1007/s11892-009-0078-6Authors Alan Chait, Department of Medicine, University of Washington Division of Metabolism, Endocrinology and Nutrition, Diabetes and Obesity Center of Excellence Mailstop 358055, 815 Mercer Street Seattle WA 98109 USA Journal Current Diabetes ReportsOnline ISSN 1539-0829Print ISSN 1534-4827 Journal Volume Volume -1 Journal Issue Volume -1, Online First / January, 2010 (Source: Current Diabetes Reports)

Spatial Clustering of Myelodysplastic Syndromes (MDS) in the Seattle-Puget Sound Region of Washington State

Cancer Causes and Control — Mon, 25 Jan 2010 17:00:09 +0100

Conclusion Interpretation is limited because our data are based on the residential location of the MDS case only at the time of diagnosis. Nevertheless, inclusion of identified cluster regions in future population-based research and investigation of individual-level exposures could shed light on environmental risk factors for MDS. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-010-9509-6Authors Michelle E. Ross, University of Washington Department of Biostatistics Seattle WA USAJon Wakefield, University of Washington Department of Biostatistics Seattle WA USAScott Davis, Fred Hutchinson Cancer Research Center Division of Public Health Sciences 1100 Fairview Avenue N, M4-B874 Seattle WA 98109-1024 USAAnneclaire J. De Roos, Fred Hutchinson Cancer ...

Studies shed new light on early transmembrane signaling

EurekAlert! - Medicine and Health — Mon, 25 Jan 2010 05:00:00 +0100

(Rockefeller University Press) Two new studies by researchers at the University of Washington further our understanding of the molecular steps in the PLC cascade, a G protein-coupled receptor signaling mechanism that underlies a wide variety of cellular processes, including egg fertilization, hormone secretion, and the regulation of certain potassium channels. The studies appear online Jan. 25 in the Journal of General Physiology. (Source: EurekAlert! - Medicine and Health)

[Newsdesk] Specialists mourn death of Walter Stamm

The Lancet Infectious Diseases — Mon, 25 Jan 2010 00:00:00 +0100

Walter Stamm, the infectious disease expert who revolutionised management of urinary tract infections and pelvic inflammatory disease, died on Dec 14 from malignant melanoma, aged 64 years. Worldwide, the specialty is mourning the notable professor of medicine and former head of the division of allergy and infectious disease at the University of Washington (Seattle, WA, USA). (Source: The Lancet Infectious Diseases)

Exploring the impact of changes in neurogenic urinary incontinence frequency and condition-specific quality of life on preference-based outcomes

Quality of Life Research — Fri, 22 Jan 2010 09:54:16 +0100

Conclusions These estimates provide preliminary data for decision analysts wishing to map neurogenic UI outcomes to preference scores. Content Type Journal ArticleDOI 10.1007/s11136-010-9590-zAuthors William Hollingworth, University of Bristol Department of Social Medicine Canynge Hall, 39 Whatley Rd Bristol BS8 2PS UKJonathan D. Campbell, University of Washington Pharmaceutical Outcomes Research and Policy Program Seattle WA USAJonathan Kowalski, Global Health Outcomes Strategy & Research, Allergan, Inc Irvine CA USAArliene Ravelo, Global Health Outcomes Strategy & Research, Allergan, Inc Irvine CA USAIsabelle Girod, Global Health Outcomes Strategy & Research, Allergan, Inc Irvine CA USAAndrew Briggs, University of Glasgow Public Health and Health Policy Glasgow UKSean...

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HDL Lipids and Insulin Resistance

Current Diabetes Reports — Fri, 22 Jan 2010 02:11:14 +0100

This article focuses on the universe of HDL lipids and their potential protective or proinflammatory roles in vascular disease and insulin resistance. HDL carries a wide array of lipids including sterols, triglycerides, fat-soluble vitamins, and a large number of phospholipids, including phosphatidylcholine, sphingomyelin, and ceramide with many biological functions. Ceramide has been implicated in the pathogenesis of insulin resistance and has many proinflammatory properties. In contrast, sphingosine-1-phosphate, which is transported mainly in HDL, has anti-inflammatory properties that may be atheroprotective and may account for some of the beneficial effects of HDL. However, the complexity of the HDL lipidome is only beginning to reveal itself. The emergence of new analytical techn...

Virtual Reality Helps Veteran Burn Patients

SCCM RSS News — Thu, 21 Jan 2010 15:38:24 +0100

As hundreds of troops return from the wars in Afghanistan and Iraq with extensive combat burns, National Public Radio featured an Army hospital in Texas experimenting with a virtual reality program that can distract burn victims and help alleviate pain. SnowWorld, developed by researchers at the University of Washington, allows burn victims to navigate an icy canyon as they push buttons to throw snowballs at giant penguins or mammoths... (Source: SCCM RSS News)

Asian ozone boosts smog levels in US

Guardian Unlimited Science — Thu, 21 Jan 2010 11:44:44 +0100

Scientists discover link between atmospheric ozone over US and pollution from burning fossil fuels during Asian economic boomOzone blowing over from Asia is raising background levels of a major ingredient of smog in the skies over western US states, according to a new study appearing in today's edition of the journal Nature.The amounts are small and, so far, only found in a region of the atmosphere known as the free troposphere, at an altitude of two to five miles, but the development could complicate US efforts to control air pollution.Though the levels are small, they have been steadily rising since 1995, and probably longer, said lead author Owen R Cooper, a research scientist at the University of Colorado attached to the National Oceanic and Atmospheric Administration's Earth System Re...

Managing Pacific Northwest dams for a changing climate

EurekAlert! - Biology — Thu, 21 Jan 2010 05:00:00 +0100

(University of Washington) Civil engineers at the University of Washington and the US Army Corps of Engineers' Seattle office have taken a first look at how dams in the Columbia River basin, the nation's largest hydropower system, could be managed for a different climate. (Source: EurekAlert! - Biology)

Herpes medication does not reduce risk of HIV transmission, UW-led international study finds

EurekAlert! - Medicine and Health — Wed, 20 Jan 2010 05:00:00 +0100

(University of Washington - Health Sciences/UW News, Community Relations & Marketing) A five-year international multi-center clinical trial has found that acyclovir, a drug widely used as a safe and effective treatment to suppress herpes simplex virus-2 (HSV-2), the most common cause of genital herpes, does not reduce the risk of HIV transmission when taken by people infected with both HIV and HSV-2. The results are published in the New England Journal of Medicine online today, and will appear in the journal's Feb. 4, 2010 issue. (Source: EurekAlert! - Medicine and Health)

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Mental Illness -- Leading Cause of Hospitalization Among Children and Adolescents in Washington State

About.com Mental Health — Wed, 20 Jan 2010 00:00:00 +0100

A recent University of Washington study of hospital admissions figures for children and teenagers shows that while overall hospital admissions decreased for this group in the 1990s, mental illness became the leading cause of hospitalization for them. (Source: About.com Mental Health)

Preference values associated with stage III colon cancer and adjuvant chemotherapy

Quality of Life Research — Tue, 19 Jan 2010 06:45:58 +0100

Conclusions The findings highlight the trade-offs between the disutility of adjuvant treatment, the higher utility of remission, and the severe utility loss during metastatic disease. The preference values obtained from this study will be useful for informing patients’ treatment decisions and payer cost-utility analyses of adjuvant treatment for colon cancer. Content Type Journal ArticleDOI 10.1007/s11136-010-9589-5Authors Jennie H. Best, University of Washington Seattle WA USALouis P. Garrison, University of Washington Seattle WA USAWilliam Hollingworth, University of Washington Seattle WA USAScott D. Ramsey, University of Washington Seattle WA USADavid L. Veenstra, University of Washington Seattle WA USA Journal Quality of Life ResearchOnline ISSN 1573-2649...

Neurotoxicity of Cancer Treatment

Current Oncology Reports — Mon, 18 Jan 2010 18:25:27 +0100

Abstract Cancer therapy—including brain-directed surgery, brain or spine irradiation, or chemotherapy—may affect the nervous system in a deleterious manner, affecting either the central or peripheral nervous systems. The causation of encephalopathy (eg, radiation, chemotherapy) is most relevant for the differential diagnosis of central nervous system (CNS) disorders, as defining a specific cause determines further treatment and outcome. Peripheral nervous system disorders (ie, steroid myopathy, spindle poison, or platinum neuropathy) are predominantly treatment related and respond best to discontinuation of the neurotoxic agent. Content Type Journal ArticleDOI 10.1007/s11912-009-0072-9Authors Marc C. Chamberlain, University of Washington, Fred Hutchinson Cancer Res...

'Greenroads' rates sustainable road projects

EurekAlert! - Social and Behavioral Science — Wed, 13 Jan 2010 05:00:00 +0100

(University of Washington) A newly released rating system, Greenroads, aims to do for road construction what the LEED system has done for the building industry. The document released today assigns up to 118 credits for sustainable practices. (Source: EurekAlert! - Social and Behavioral Science)

Dog genome researchers track paw prints of selective breeding

EurekAlert! - Social and Behavioral Science — Wed, 13 Jan 2010 05:00:00 +0100

(University of Washington) Researchers gave identified 155 regions on the dog genome that appear to have been influenced by selective breeding. Although dogs have been domesticated for 14,000 years, their spectacular diversity originated over the past several centuries through intense artificial selection. (Source: EurekAlert! - Social and Behavioral Science)

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Microbe understudies await their turn in the limelight

EurekAlert! - Biology — Mon, 11 Jan 2010 05:00:00 +0100

(University of Washington) On the marine microbial stage, there appears to be a vast, varied group of understudies only too ready to step in when "star" microbes falter. Work led by the University of Washington provides the first evidence that microorganisms can be rare for long periods before completely turning the tables to become dominant when ecosystems change. (Source: EurekAlert! - Biology)

Delta/Notch-Like EGF-Related Receptor (DNER) is Expressed in Hair Cells and Neurons in the Developing and Adult Mouse Inner Ear

JARO - Journal of the Association for Research in Otolaryngology — Fri, 08 Jan 2010 09:09:38 +0100

Abstract The Notch signaling pathway is known to play important roles in inner ear development. Previous studies have shown that the Notch1 receptor and ligands in the Delta and Jagged families are important for cellular differentiation and patterning of the organ of Corti. Delta/notch-like epidermal growth factor (EGF)-related receptor (DNER) is a novel Notch ligand expressed in developing and adult CNS neurons known to promote maturation of glia through activation of Notch. Here we use in situ hybridization and an antibody against DNER to carry out expression studies of the mouse cochlea and vestibule. We find that DNER is expressed in spiral ganglion neuron cell bodies and peripheral processes during embryonic development of the cochlea and expression in these cells is ...

Joint quality improvement guidelines for pediatric arterial access and arteriography: from the Societies of Interventional Radiology and Pediatric Radiology

Pediatric Radiology — Thu, 07 Jan 2010 22:54:10 +0100

Content Type Journal ArticleCategory Standards of PracticeDOI 10.1007/s00247-009-1499-8Authors Manraj K. S. Heran, British Columbia Children’s Hospital Department of Radiology Vancouver British Columbia CanadaFrancis Marshalleck, Riley Hospital for Children Department of Radiology Indianapolis IN USAMichael Temple, University of Toronto Department of Medical Imaging Toronto Ontario CanadaClement J. Grassi, Boston Healthcare System Veterans Affairs Medical Center Department of Radiology Boston MA USABairbre Connolly, University of Toronto Department of Medical Imaging Toronto Ontario CanadaRichard B. Towbin, Phoenix Children’s Hospital Department of Radiology Phoenix AZ USAKevin M. Baskin, Children’s Hospital of Pittsburgh Division of Cardiovascular and Interventional Radiology, D...

Ipratropium Bromide May Increase Risk For Cardiovascular Events

Health News from Medical News Today — Thu, 07 Jan 2010 08:00:00 +0100

Patients taking ipratropium bromide, an anticholinergic used in the treatment of COPD, may be at an increased risk for cardiovascular events (CVE), including heart failure. Researchers from the University of Washington in Seattle, WA, and Hines VA Hospital in Hines, IL, conducted a cohort study on 82,717 US veterans with a new diagnosis of COPD between 1999 and 2002. Of the patients, 44 percent were exposed to anticholinergics (mainly ipratropium) at some time during the study... (Source: Health News from Medical News Today)

Ipratropium Bromide May Increase Risk For Cardiovascular Events

Cardiovascular / Cardiology News From Medical News Today — Thu, 07 Jan 2010 08:00:00 +0100

Patients taking ipratropium bromide, an anticholinergic used in the treatment of COPD, may be at an increased risk for cardiovascular events (CVE), including heart failure. Researchers from the University of Washington in Seattle, WA, and Hines VA Hospital in Hines, IL, conducted a cohort study on 82,717 US veterans with a new diagnosis of COPD between 1999 and 2002... (Source: Cardiovascular / Cardiology News From Medical News Today)

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Study: Health Center, Family Medicine Residency Pairing Is 'Match Made in Heaven'

AAFP Resident and Student Focus — Thu, 07 Jan 2010 01:25:00 +0100

Training family medicine residents in community health centers, or CHCs, may provide a solution to the primary care workforce shortage, according to a study by two family physicians in Seattle. Such affiliations can be encouraged through changes in graduate medical education, or GME, funding and other proposals being discussed as part of health care reform, say the two FPs. The study by Carl Morris, M.D., M.P.H., associate director of the Group Health Family Medicine Residency, Seattle, and Frederick Chen, M.D., M.P.H, assistant professor in the University of Washington Department of Family Medicine, Seattle, appears in the November/December issue of Annals of Family Medicine. (Source: AAFP Resident and Student Focus)

Development of an automated steering mechanism for bladder urothelium surveillance - Abstract

UroToday — Tue, 05 Jan 2010 23:00:00 +0100

Department of Mechanical Engineering, University of Washington, Seattle, WA 98195. (Source: UroToday)

Relationship of Opioid Use and Dosage Levels to Fractures in Older Chronic Pain Patients

Journal of General Internal Medicine — Mon, 04 Jan 2010 18:01:39 +0100

Conclusions Higher doses (≥50 mg/day) of opioids for chronic non-cancer pain were associated with a 2.00 increase in risk of fracture confirmed by medical record review. Clinicians should consider fracture risk when prescribing higher-dose opioid therapy for older adults. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11606-009-1218-zAuthors Kathleen W. Saunders, Group Health Research Institute 1730 Minor Avenue, Suite 1600 Seattle WA 98101 USAKate M. Dunn, Keele University Arthritis Research Campaign National Primary Care Centre Keele UKJoseph O. Merrill, University of Washington Department of Medicine Seattle WA USAMark Sullivan, University of Washington Department of Psychiatry and Behavioral Sciences Seattle WA USAConstance Weisner, North...

Toxicants detected in Asian monkey hair may warn of environmental threats to people and wildlife

EurekAlert! - Social and Behavioral Science — Mon, 04 Jan 2010 05:00:00 +0100

(University of Washington) Testing hair from Asian monkeys in dense urban areas may provide early warnings of toxic threats to humans, especially children, and wildlife. A study of young macaques at the Swoyambhu Temple in Nepal revealed lead exposure. The monkeys live in close proximity to people in a location with discarded lead batteries, flaking lead paint, and soil contaminated by leaded fuel. Like toddlers, monkeys are curious explorers who put found objects in their mouths. (Source: EurekAlert! - Social and Behavioral Science)

Measurement and correlates of ano-genital distance in healthy, newborn infants.

International Journal of Andrology — Mon, 04 Jan 2010 00:00:00 +0100

Authors: Sathyanarayana S, Beard L, Zhou C, Grady R Summary Ano-genital distance (AGD) is a sexually dimorphic trait that is a well established reproductive toxicity endpoint in animals. In male animals, a shortened AGD is associated with a variety of genital abnormalities including hypospadias and cryptorchidism. Consensus on the anatomical definition of AGD in humans remains to be established and few data exist on the determinants and normal variance in the general population. We implemented a standardized anthropometric protocol to measure AGD, ano-scrotal distance (ASD), and ano-fourchette distance (AFD) in 169 (82 male, 87 female) infants in the University of Washington newborn nursery in 2008. We collected data on the following characteristics: weight, length, and occipital head ...

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Effectiveness of the cervical vertebral maturation method to predict postpeak circumpubertal growth of craniofacial structures

American Journal of Orthodontics and Dentofacial Orthopedics — Thu, 31 Dec 2009 13:58:00 +0100

Introduction: Our aim was to assess effectiveness of the cervical vertebral maturation (CVM) method to predict circumpubertal craniofacial growth in the postpeak period.Methods: The CVM stage was determined in 176 subjects (51 adolescent boys and 125 adolescent girls) on cephalograms taken at the end of treatment (T2; mean ages, 15.75 years [boys] and 15.23 years [girls]) in subjects from the postretention database at the University of Washington in Seattle. Craniofacial growth was evaluated from the following measurements on cephalograms at T2 and end of follow-up (T3) (mean ages, 29.01 years [men] and 28.08 years [women]): condylion to gnathion, condylion to gonion, gonion to gnathion, sella to gnathion, nasion to menton, anterior nasal spine to menton, and sella to gonion. The change of...

Your copyright and the SPARC author addendum

American Journal of Orthodontics and Dentofacial Orthopedics — Thu, 31 Dec 2009 13:57:57 +0100

What does it mean to hold the copyright to a manuscript or other printed material? During a panel discussion at the University of Washington entitled, “Publishing your work in the digital age,” Clark Shores, Assistant Attorney General of the state of Washington, answered questions about authors' rights. According to Shores, “You own copyright to anything you write just as soon as it is created. You don't have to do a thing to own this copyright.” Registering your copyright gives you added protections if a legal dispute arises. But even with that, owning a copyright and enforcing it are 2 different things. As I learned more about copyrights and authors' rights, it became clear to me that it is a complex issue, especially in the digital age. (Source: American Journal of Orthodontics ...

Biostatistics To Evaluate Vaccine Efficacy, The Study Of The Spread Of Infectious Diseases: M. Elizabeth Halloran Named AAAS Fellow

Health News from Medical News Today — Thu, 31 Dec 2009 08:00:00 +0100

Fred Hutchinson Cancer Research Center scientist M. Elizabeth "Betz" Halloran, M.D., M.P.H., D.S.c., has been awarded the distinction of AAAS Fellow. Election as a Fellow is an honor bestowed upon members of the American Association for the Advancement of Science, or AAAS, by their peers. Halloran is a researcher in the Hutchinson Center's Vaccine and Infectious Disease Institute and a professor of biostatistics at the University of Washington... (Source: Health News from Medical News Today)

Nobel winner shed light on cell functions

OrlandoSentinel: Medical Research — Thu, 31 Dec 2009 00:00:00 +0100

Dr. Edwin G. Krebs, the University of Washington Nobel laureate who co-discovered the mechanism by which a wide variety of processes are turned on and off within the cell, leading to an explosion of knowledge about how cells grow, change, divide and die,... (Source: OrlandoSentinel: Medical Research)

Introduction for The Editor's Workshop

Journal of Pediatric and Adolescent Gynecology — Tue, 29 Dec 2009 14:47:51 +0100

Allow me to highlight our guest editor for this issue of the Journal of Pediatric and Adolescent Gynecology, Dr. Gina Sucato. Gina serves as Associate Editor for Pediatric Adolescent Medicine. She is in the Division of Adolescent Medicine at the University of Pittsburgh School of Medicine. Her undergraduate training was at Cornell, and she received her medical degree from the University of Pennsylvania. Dr. Sucato is also an MPH; she completed this degree at the University of Washington School of Public Health and Community Medicine. Her pediatric training was at the University of Washington, and her fellowship in adolescent medicine was at the University of Pittsburgh. (Source: Journal of Pediatric and Adolescent Gynecology)

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Dr. Edwin G. Krebs dies at 91; Nobel laureate co-discovered fundamental cell processes

Los Angeles Times - Science — Tue, 29 Dec 2009 06:02:00 +0100

The University of Washington biochemist co-discovered the mechanism that causes cells to grow, change divide and die. It launched an explosion of knowledge about diseases, medicines and metabolics. Dr. Edwin G. Krebs, the University of Washington Nobel laureate who co-discovered the mechanism by which a wide variety of processes are turned on and off within cells and thereby led to an explosion of knowledge about how cells grow, change, divide and die, died Dec. 21 in Seattle from progressive heart failure. He was 91. (Source: Los Angeles Times - Science)

Dr. Edwin G. Krebs dies at 91; Nobel laureate co-discovered fundamental cell processes

OrlandoSentinel: Medical Research — Mon, 28 Dec 2009 22:02:00 +0100

Dr. Edwin G. Krebs, the University of Washington Nobel laureate who co-discovered the mechanism by which a wide variety of processes are turned on and off within cells and thereby led to an explosion of knowledge about how cells grow, change, divide and... (Source: OrlandoSentinel: Medical Research)

Standard chemoradiation versus intensity-modulated chemoradiation: a quality of life assessment in oropharyngeal cancer patients

European Archives of Oto-Rhino-Laryngology — Mon, 28 Dec 2009 19:13:52 +0100

In conclusion, CIMRT results in improved QOL for some domains but surprisingly not for swallowing or saliva. Patients undergoing CIMRT also report slightly better QOL overall when compared to patients receiving more traditional forms of radiation therapy. Content Type Journal ArticleCategory Head and NeckDOI 10.1007/s00405-009-1183-5Authors Sarah E. Mowry, University of California, Los Angeles Division of Head and Neck Surgery, David Geffen School of Medicine 62-132 CHS BOX 951624 Los Angeles CA 90095-1624 USAChristopher Tang, University of California, Los Angeles Division of Head and Neck Surgery, David Geffen School of Medicine 62-132 CHS BOX 951624 Los Angeles CA 90095-1624 USAAhmad Sadeghi, VA Greater Los Angeles Healthcare System Department of Radiation Oncology Los Angeles USA...

Dr. Edwin G. Krebs dies at 91; Nobel laureate discovered fundamental cell processes

OrlandoSentinel: Medical Research — Mon, 28 Dec 2009 17:36:00 +0100

Walter Stamm dies at 64; doctor saved thousands of women from infertility

Los Angeles Times - Science — Sat, 26 Dec 2009 08:00:00 +0100

The University of Washington physician transformed the diagnosis and treatment of genitourinary infections. Dr. Walter E. Stamm, whose discoveries on the diagnosis and treatment of urinary tract infections and of the relationship between chlamydia and pelvic inflammatory disease saved tens of thousands of women from infertility, died Dec. 14 at his home in Seattle. He was 64 and had been battling melanoma. (Source: Los Angeles Times - Science)

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"Evolution in Extreme Environments" Cosponsored by AIBS and NESCent

AIBS News — Fri, 25 Dec 2009 15:44:35 +0100

AIBS and the National Evolutionary Synthesis Center (NESCent) are cosponsoring the sixth annual evolution symposium on Friday, 13 November, at the National Association of Biology Teachers' 2009 Professional Development Conference in Denver, Colorado. The four speakers who will discuss the symposium's theme, "Evolution in Extreme Environments," are Cynthia M. Beall, of Case Western Reserve University; Jody W. Deming, of the University of Washington; Steven Haddock, of Monterey Bay Aquarium Research Institute, and William R. Jeffery, of the University of Maryland. A workshop will take place in the afternoon for educators seeking resources to incorporate evolution in extreme environments into their classrooms. Conference registration is required to attend the symposium and workshop. Visit w...

Mesh-fixation method and pain and quality of life after laparoscopic ventral or incisional hernia repair: a randomized trial of three fixation techniques

Surgical Endoscopy — Thu, 24 Dec 2009 19:57:10 +0100

Conclusion In this trial, the three mesh-fixation methods were associated with similar postoperative pain and QoL findings. These results suggest that none of the techniques can be considered to have a pain-reduction advantage over the others. Development of new methods for securing the mesh may be required to decrease the rate or severity of pain after LVIHR. Content Type Journal ArticleDOI 10.1007/s00464-009-0763-1Authors Eelco Wassenaar, University of Washington Center for Video-endoscopic Surgery, Department of Surgery 1959 NE Pacific Street Box 356410 Seattle WA 98195 USAErnst Schoenmaeckers, Twenteborg Hospital Department of Surgery PO Box 7600 7600 SZ Almelo The NetherlandsJohan Raymakers, Twenteborg Hospital Department of Surgery PO Box 7600 7600 SZ Almelo The...

Communicating about the experience of pain and fatigue in disability

Quality of Life Research — Thu, 24 Dec 2009 19:48:37 +0100

Conclusions Pain and fatigue were viewed as having many facets that are associated in complex ways with other aspects of the health/disability condition. From the participants’ perspective, assignment of a pain intensity rating does not represent the complexity of their pain experience. Suggestions are provided for HCPs when communicating about pain and fatigue with people with chronic conditions. Content Type Journal ArticleDOI 10.1007/s11136-009-9572-1Authors Kathryn M. Yorkston, University of Washington Department of Rehabilitation Medicine Box 356490 Seattle WA 98195-6490 USAKurt Johnson, University of Washington Department of Rehabilitation Medicine Box 356490 Seattle WA 98195-6490 USAErin Boesflug, University of Washington Department of Rehabilitation Medicin...

Phenotypic Characteristics and Diagnoses of Patients Referred to an Iron Overload Clinic

Digestive Diseases and Sciences — Thu, 24 Dec 2009 19:47:49 +0100

Conclusions (1) A large proportion of patients referred for suspected iron overload have diagnoses other than HH. (2) NAFLD, chronic hepatitis C, and chronic alcohol use were the most common alternative diagnoses. (3) Arthralgia and fatigue are the most common symptoms among patients with HH. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-009-1080-1Authors John B. Dever, Virginia Mason Medical Center Digestive Disease Institute, Liver Center of Excellence 1201 9th Ave Seattle WA USAMark A. Mallory, University of Washington School of Medicine Seattle WA USAJulie E. Mallory, Williams College Williamstown MA USADorothy Wallace, Virginia Mason Medical Center Digestive Disease Institute, Liver Center of Excellence 1201 9th Ave Seattle WA USAKris V....

Air bags not a risk to pregnant women in motor vehicle crashes, study finds

uwnews.org | Health and Medicine — Mon, 21 Dec 2009 21:38:00 +0100

A new ground-breaking study from University of Washington researchers has found that air bags do not seem to elevate risk of most potential adverse outcomes during pregnancy. (Source: uwnews.org | Health and Medicine)

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Recommendations for research priorities in breast cancer by the coalition of cancer cooperative groups scientific leadership council: imaging and local therapy

Breast Cancer Research and Treatment — Fri, 18 Dec 2009 16:12:47 +0100

Abstract Imaging and local therapy are important modalities for detection and management of localized breast cancer. Improvements in screening and local therapy have contributed to reduced breast cancer-associated morbidity and mortality. The Coalition of Cancer Cooperative Groups (CCCG) convened the Scientific Leadership Council (SLC) in breast cancer, an expert panel, to identify priorities for future research and current trials with greatest practice-changing potential. Panelists formed a consensus on research priorities for breast imaging and locoregional therapy, and also identified six trials judged to be of high priority. Current high priority trials included trials determining: (1) the role of accelerated partial breast versus whole-breast radiation (B39), (2) the ...

JAMA Editorial: Time For A New View Of Late-life Dementia

Health News from Medical News Today — Thu, 17 Dec 2009 02:00:00 +0100

Two new studies published in the December 16, 2009 issue of the Journal of the American Medical Association point to the need for a broader scientific perspective on late-life dementia, according to an editorial in the same issue by Thomas J. Montine, MD, PhD, University of Washington (UW) professor of neuropathology, and Eric B. Larson, MD, MPH, executive director of Group Health Research Institute. One study, led by Robert C... (Source: Health News from Medical News Today)

JAMA Editorial: Time For A New View Of Late-life Dementia

Alzheimer's / Dementia News From Medical News Today — Thu, 17 Dec 2009 02:00:00 +0100

Two new studies published in the December 16, 2009 issue of the Journal of the American Medical Association point to the need for a broader scientific perspective on late-life dementia, according to an editorial in the same issue by Thomas J. Montine, MD, PhD, University of Washington (UW) professor of neuropathology, and Eric B... (Source: Alzheimer's / Dementia News From Medical News Today)

JAMA Editorial: Time For A New View Of Late-life Dementia

Alzheimer's / Dementia News From Medical News Today — Thu, 17 Dec 2009 02:00:00 +0100

Two new studies published in the December 16, 2009 issue of the Journal of the American Medical Association point to the need for a broader scientific perspective on late-life dementia, according to an editorial in the same issue by Thomas J. Montine, MD, PhD, University of Washington (UW) professor of neuropathology, and Eric B... (Source: Alzheimer's / Dementia News From Medical News Today)

Splenic artery aneurysm: a diagnostic challenge in the setting of extensive portal venous collaterals

Pediatric Radiology — Tue, 15 Dec 2009 06:46:08 +0100

We present a 16-year-old boy with autoimmune liver disease and longstanding portal hypertension in whom a CT arteriogram demonstrated a large aneurysm arising from the distal, extra-parenchymal portion of the splenic artery. Because of its location adjacent to multiple venous collaterals, the aneurysm was indistinguishable from splenic varices on initial imaging with Doppler sonography and on portal venous-phase CT. There is an increased risk of rupture of splenic artery aneurysms in the post-liver transplant period, with high associated mortality, and therefore diagnosis of splenic artery aneurysm prior to liver transplantation is clinically important. It is quite possible that the diagnosis of splenic artery aneurysm in this case would have been missed in the absence of dedicated a...

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JAMA editorial: Time for a new view of late-life dementia

EurekAlert! - Social and Behavioral Science — Tue, 15 Dec 2009 05:00:00 +0100

(Group Health Cooperative Center for Health Studies) Two new studies published in the Dec. 16 issue of the Journal of the American Medical Association point to the need for a broader scientific perspective on late-life dementia, according to an editorial in the same issue by Thomas J. Montine, M.D., Ph.D., University of Washington (UW) professor of neuropathology, and Eric B. Larson, M.D., M.P.H., executive director of Group Health Research Institute. (Source: EurekAlert! - Social and Behavioral Science)

'I am a normal man': a narrative analysis of the accounts of older people with Down's syndrome who lived in institutionalised settings

British Journal of Learning Disabilities — Tue, 15 Dec 2009 00:00:00 +0100

This study is about the life stories of six older people with Down's syndrome who spent some part of their childhoods in institutionalised settings. They have interesting and moving stories to tell about their lives. They talked about their childhood and current lives, their likes and dislikes, their strengths and difficulties and their hopes and dreams. They also spoke about the important people in their lives. The participants did not talk about themselves as being 'old', 'disabled' or as having 'Down's syndrome'. They talked about themselves in other ways, such as being 'normal', being a 'man' or a 'beautiful lady'. The researcher learnt about herself whilst doing this study. She learned about the value of taking time to listen to people and she reflected on her own life story. This ...

Research study validates use of BI-RADS in breast MRI

Diagnostic Imaging — Mon, 14 Dec 2009 12:00:00 +0100

BI-RADS descriptors for breast MRI can help determine the risk of malignancy for lesions detected only on MRI, according to a study from the University of Washington. (Source: Diagnostic Imaging)

Of girls and geeks: Enivronment may be why women don't like computer science

EurekAlert! - Social and Behavioral Science — Mon, 14 Dec 2009 05:00:00 +0100

(University of Washington) In real estate, it's location, location, location. And when it comes to why girls and women shy away from careers in computer science, a key reason is environment, environment, environment. (Source: EurekAlert! - Social and Behavioral Science)