MedWorm: Washington University

Confidence Is Key To Gauging Impressions We Make

Health News from Medical News Today — Fri, 12 Mar 2010 08:00:00 +0100

The gift of "seeing ourselves as others see us" is particularly beneficial when we judge how we've made a first impression - in a job interview, during a sales pitch or on a first date. Yet, many come away from these situations with at best a vague notion of how that first impression was perceived or at worst no clue at all. Now, psychologists at Washington University in St. Louis and Wake Forest University have tested people in first impression settings in the laboratory and have found that confidence makes all the difference in knowing whether you've hit a homerun or struck out... (Source: Health News from Medical News Today)

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Confidence Is Key To Gauging Impressions We Make

Psychology / Psychiatry News From Medical News Today — Fri, 12 Mar 2010 08:00:00 +0100

American Society for Microbiology honors Wm. Michael Dunne, Jr.

EurekAlert! - Biology — Thu, 11 Mar 2010 05:00:00 +0100

(American Society for Microbiology) The 2010 American Society for Microbiology TREK Diagnostic ABMM/ABMLI Professional Recognition Award is presented to Wm. Michael Dunne, Jr., Ph.D., D (ABMM), Medical Director, Clinical Microbiology Laboratory, Barnes-Jewish Hospital, and Professor, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, for his leadership in clinical microbiology and for revolutionizing the delivery of the American Board of Medical Microbiology (ABMM) certification examination. (Source: EurekAlert! - Biology)

Washington University gets $14M in stimulus for genomic data center

bizjournals.com Health Care:Biotechnology headlines — Wed, 10 Mar 2010 20:03:39 +0100

Washington University School of Medicine in St. Louis has received a $14.3 million grant through the American Recovery and Reinvestment Act to expand its data center for genomics. (Source: bizjournals.com Health Care:Biotechnology headlines)

Confidence is key to gauging impressions we make

EurekAlert! - Social and Behavioral Science — Wed, 10 Mar 2010 05:00:00 +0100

(Washington University in St. Louis) The gift of "seeing ourselves as others see us" comes in handy when judging how we've made a first impression. Yet many come away with little or no clue about how that first impression was perceived. A new study suggests confidence is a key indicator of how well we've assessed impressions left behind. (Source: EurekAlert! - Social and Behavioral Science)

Foreword

Current Problems in Surgery — Mon, 08 Mar 2010 16:48:45 +0100

In this issue of Current Problems in Surgery, Drs. Avihu Gazit, Charles Huddleston, Paul Checchia, James Fehr, and A. Thomas Pezzella from Washington University in St. Louis complete their two-issue monograph entitled, “Care of the Pediatric Cardiac Surgery Patient.” This issue, part 2, begins with a discussion of outcome prediction and the transition from surgery to postoperative care. Subsequent management, including monitoring and a subsystem approach to the complete care of these patients, is covered in significant detail, including the wide variety of complications that may accompany these complex operations. The monograph concludes with a discussion of special conditions, ranging from single ventricle physiology to pediatric cardiac surgery in developing countries. This thorough ...

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Siteman, Washington University get $1.7M to tackle endometrial cancer

bizjournals.com Health Care:Biotechnology headlines — Mon, 08 Mar 2010 16:43:46 +0100

The National Cancer Institute has awarded the Siteman Cancer Center and Washington University School of Medicine in St. Louis a $1.7 million, three-year grant to study endometrial cancer. (Source: bizjournals.com Health Care:Biotechnology headlines)

Successful Treatment Of Periodontal Disease Lowered Preterm Birth Incidences

Health News from Medical News Today — Mon, 08 Mar 2010 09:00:00 +0100

Previous studies have explored the effect of periodontal treatment, irrespective of efficacy of treatment, in reducing infant prematurity. In a study titled "Risk of Preterm Birth Is Reduced with Successful Periodontal Treatment," lead researcher M. Jeffcott, and colleagues S. Parry and M. Sammel (all from the University of Pennsylvania, Philadelphia) and G. Macones (Washington University, St. Louis, Missouri) determined whether a reduction in infant prematurity was associated with successful periodontal treatment... (Source: Health News from Medical News Today)

Successful Treatment Of Periodontal Disease Lowered Preterm Birth Incidences

Dentistry News From Medical News Today — Mon, 08 Mar 2010 09:00:00 +0100

Previous studies have explored the effect of periodontal treatment, irrespective of efficacy of treatment, in reducing infant prematurity. In a study titled "Risk of Preterm Birth Is Reduced with Successful Periodontal Treatment," lead researcher M. Jeffcott, and colleagues S. Parry and M. Sammel (all from the University of Pennsylvania, Philadelphia) and G. Macones (Washington University, St... (Source: Dentistry News From Medical News Today)

Talking Your Way To Happiness: Well-being Is Related To Having Less Small Talk And More Substantive Conversations

Health News from Medical News Today — Mon, 08 Mar 2010 08:00:00 +0100

Is a happy life filled with trivial chatter or reflective and profound conversations? Psychological scientists Matthias R. Mehl, Shannon E. Holleran, and C. Shelby Clark from the University of Arizona, along with Simine Vazire of Washington University in St. Louis investigated whether happy and unhappy people differ in the types of conversations they tend to engage in. Volunteers wore an unobtrusive recording device called the Electronically Activated Recorder (EAR) over four days. This device periodically records snippets of sounds as participants go about their lives... (Source: Health News from Medical News Today)

Talking Your Way To Happiness: Well-being Is Related To Having Less Small Talk And More Substantive Conversations

Psychology / Psychiatry News From Medical News Today — Mon, 08 Mar 2010 08:00:00 +0100

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Vitamin A and Hirschsprung Disease

Neuromics — Sat, 06 Mar 2010 22:57:00 +0100

In this study, he and his team find a link between Vitamin A and the disease. This suggests that some cases of Hirschsprung disease might be preventable by optimizing maternal nutrition.Ming Fu, Yoshiharu Sato, Ariel Lyons-Warren, Bin Zhang, Maureen A. Kane, Joseph L. Napoli, and Robert O. Heuckeroth Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation. Development, Feb 2010; 137: 631 - 640. Featured Reagent: Ret Related Reagents:Ret BiotinylatedRet (C-Terminus Fused)Ret-Fluorescein LabeledRet-Allophycocyanin LabeledRet-Phycoerythrin LabeledNeurotrophins and Growth Factor AntibodiesNeurotrophins-Neuron/Glial Marker Recombinant ProteinsNeuron/Glial MarkersStem Cell Research Reagents (Source: Neuromics)

Intense War News Reduces Ability To Remember Ads

Health News from Medical News Today — Sat, 06 Mar 2010 08:00:00 +0100

A new study shows that the more graphic and intense war news is, the less likely that viewers - regardless of political beliefs - will remember the advertising that follows the news. However, the researchers did find that lower-intensity programming resulted in a better recall of the advertising by proponents of the war. The research, featured in a forthcoming issue of the Journal of Current Issues and Research in Advertising, was conducted by Keven Malkewitz, assistant professor of marketing at Oregon State University, and Damon Aiken of Eastern Washington University... (Source: Health News from Medical News Today)

Siteman, Wash. U get $1.7M grant

bizjournals.com Health Care:Biotechnology headlines — Sat, 06 Mar 2010 02:33:45 +0100

The Siteman Cancer Center and Washington University School of Medicine in St. Louis were awarded a three-year, $1.7 million grant by the National Cancer Institute (NCI) to study endometrial cancer. (Source: bizjournals.com Health Care:Biotechnology headlines)

Helping Heroes and Screening the Disaster Tourists

Psychology Today Work Center — Fri, 05 Mar 2010 20:55:09 +0100

I was recently quoted by ABC news on the psycho-physiological risks of disasters on non-psychiatric chronic illnesses in Chile and the importance of relief aid in reducing the risks of depression and post traumatic stress disorder (PTSD) in the aftermath of the Haitian earthquake. Yet despite the occasional media attention on the impact of these tragedies on the local population of Haiti and Chile, the psychological well-being of emergency health responders themselves continues to be ignored in the media and the larger public health debate on the outcome of these devastating earthquakes. Indeed, disasters require that we respond not only to those who require immediate psychosocial help amongst the local effected population, but also to the psychological well-being of first responders invol...

DR summit focuses on safety measures for children

Health Imaging News — Fri, 05 Mar 2010 20:00:19 +0100

In February, the Alliance for Radiation Safety in Pediatric Imaging expanded the Image Gently radiation dose initiative from CT and interventional radiology to computed radiography (CR) and digital radiography (DR) exams by hosting a Digital Radiography Summit at the Mallinckrodt Institute of Radiology at Washington University in St. Louis. (Source: Health Imaging News)

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DR summit focuses on safety measures for children

Health Imaging News — Fri, 05 Mar 2010 20:00:19 +0100

Successful treatment of periodontal disease lowered preterm birth incidences

EurekAlert! - Medicine and Health — Fri, 05 Mar 2010 05:00:00 +0100

(International & American Association for Dental Research) Previous studies have explored the effect of periodontal treatment, irrespective of efficacy of treatment, in reducing infant prematurity. In a study titled "Risk of Preterm Birth Is Reduced with Successful Periodontal Treatment," lead researcher M. Jeffcott, and colleagues S. Parry and M. Sammel (all from the University of Pennsylvania, Philadelphia) and G. Macones (Washington University, St. Louis, Mo.) determined whether a reduction in infant prematurity was associated with successful periodontal treatment. (Source: EurekAlert! - Medicine and Health)

Talking Your Way to Happiness

Medicineworld.org: New Article Alert — Fri, 05 Mar 2010 03:04:27 +0100

Is a happy life filled with trivial chatter or reflective and profound conversations? Psychological researchers Matthias R. Mehl, Shannon E. Holleran, and C. Shelby Clark from the University of Arizona, along with Simine Vazire of Washington University in St. Louis investigated whether happy and unhappy people differ in the types of conversations they tend to engage in. Volunteers wore an unobtrusive recording device called the Electronically Activated Recorder (EAR) over four days. This device periodically records snippets of sounds as participants go about their lives. For this experiment, the EAR sampled 30 seconds of sounds every 12.5 minutes yielding a total of more than 20,000 recordings. Scientists then listened to the recordings and identified the conversations as trivial small tal...

The genomics education partnership: successful integration of research into laboratory classes at a diverse group of undergraduate institutions.

CBE Life Sciences Education — Thu, 04 Mar 2010 18:56:04 +0100

Authors: Shaffer CD, Alvarez C, Bailey C, Barnard D, Bhalla S, Chandrasekaran C, Chandrasekaran V, Chung HM, Dorer DR, Du C, Eckdahl TT, Poet JL, Frohlich D, Goodman AL, Gosser Y, Hauser C, Hoopes LL, Johnson D, Jones CJ, Kaehler M, Kokan N, Kopp OR, Kuleck GA, McNeil G, Moss R, Myka JL, Nagengast A, Morris R, Overvoorde PJ, Shoop E, Parrish S, Reed K, Regisford EG, Revie D, Rosenwald AG, Saville K, Schroeder S, Shaw M, Skuse G, Smith C, Smith M, Spana EP, Spratt M, Stamm J, Thompson JS, Wawersik M, Wilson BA, Youngblom J, Leung W, Buhler J, Mardis ER, Lopatto D, Elgin SC Genomics is not only essential for students to understand biology but also provides unprecedented opportunities for undergraduate research. The goal of the Genomics Education Partnership (GEP), a collaboration between...

Raptor Pharmaceutical Announces Publication of Data Supporting Potential Efficacy of WntTide(TM) in Treatment of Triple-Negative Breast Cancer

Medical News (via PRIMEZONE) — Thu, 04 Mar 2010 11:30:00 +0100

NOVATO, Calif., March 4, 2010 (GLOBE NEWSWIRE) -- Raptor Pharmaceutical Corp. ("Raptor" or the "Company") (Nasdaq:RPTP) today announced the publication of data on a proprietary, Mesd (Mesoderm development)-based peptide, also known as WntTide(tm), licensed by Raptor from Washington University in St. Louis, in the March 1 Early Addition of Proceedings of the National Academy of Sciences. The paper, titled, "LRP6 Overexpression Defines a Class of Breast Cancer Subtype and Is a Target for Therapy," presents findings from studies conducted by the lab of Dr. Guojun Bu, the inventor of the peptide, and Professor of Pediatrics, Cell Biology and Physiology at Washington University in St. Louis. (Source: Medical News (via PRIMEZONE))

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Washington University cancer researchers get $870,000

bizjournals.com Health Care:Biotechnology headlines — Wed, 03 Mar 2010 16:07:30 +0100

Two Washington University researchers, Emily Cheng and Ellen Langer, recently won a combined $870,000 in research grants from the American Cancer Society. (Source: bizjournals.com Health Care:Biotechnology headlines)

'Stepping Up' Asthma Treatment In Children Leads To Improvement

Health News from Medical News Today — Wed, 03 Mar 2010 10:00:00 +0100

Children with asthma who continue to have symptoms while using low-dose inhaled corticosteroids could benefit from increasing the dosage or adding one of two asthma drugs, a new study by researchers at Washington University School of Medicine and other institutions finds. Results of the study, called BADGER (Best ADd-on therapy Giving Effective Responses) may also allow physicians to better predict which of the three options will help a patient the most... (Source: Health News from Medical News Today)

'Stepping Up' Asthma Treatment In Children Leads To Improvement

Pediatrics News From Medical News Today — Wed, 03 Mar 2010 10:00:00 +0100

Prospective randomized controlled trial of an injectable esophageal prosthesis versus a sham procedure for endoscopic treatment of gastroesophageal reflux disease

Surgical Endoscopy — Wed, 03 Mar 2010 08:51:11 +0100

Conclusions The GK procedure was associated with some serious but infrequent complications. No statistically significant difference in outcomes was observed between the treatment and control groups at 6 months compared with baseline. Content Type Journal ArticleDOI 10.1007/s00464-009-0784-9Authors Paul Fockens, Academic Medical Center, University of Amsterdam P.O. Box 22700 1100 DE Amsterdam the NetherlandsLawrence Cohen, The Mount Sinai School of Medicine New York NY USASteven A. Edmundowicz, Washington University School of Medicine 660 S. Euclid Ave. Campus Box 8124 St. Louis MO 63110 USAKenneth Binmoeller, California Pacific Medical Center San Francisco CA USARichard I. Rothstein, Dartmouth Medical School, Dartmouth Hitchcock Medical Center 1 Medical Center D...

Glaxo Birth Defect Litigation Reveals Paxil Promoters on Speed Dial

NaturalNews.com — Wed, 03 Mar 2010 07:00:00 +0100

(NaturalNews) In the first Paxil birth defect trial against GlaxoSmithKline, much of evidence focused on the doctors on Glaxo's payroll involved in the corruption of the medical literature and seminars given to promote the off label use of Paxil with pregnant and nursing mothers.On October 13, 2009, the trial of Kilker v Glaxo ended with a Philadelphia jury awarding $2.5 million in compensatory damages to the family of Lyam Kilker, after finding that Glaxo "negligently failed to warn" the doctor treating Lyam's mother about the risks of Paxil and the drug was a "factual cause" of the child's heart defects.Glaxo's lead attorney at trial was King and Spalding partner Chilton Varner, and the family's lead attorney was Sean Tracey from Houston.During his opening statement on September 15, 2009...

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New Subtype Of Breast Cancer Responds To Targeted Drug

Health News from Medical News Today — Tue, 02 Mar 2010 08:00:00 +0100

A newly identified cancer biomarker could define a new subtype of breast cancer as well as offer a potential way to treat it, say researchers at Washington University School of Medicine in St. Louis. Their findings will be published in the March 1 online early edition issue of the Proceedings of the National Academy of Sciences. The research could further refine what recent breast cancer research has concluded: that breast cancer is not one disease, but many... (Source: Health News from Medical News Today)

New Subtype Of Breast Cancer Responds To Targeted Drug

Breast Cancer News From Medical News Today — Tue, 02 Mar 2010 08:00:00 +0100

A newly identified cancer biomarker could define a new subtype of breast cancer as well as offer a potential way to treat it, say researchers at Washington University School of Medicine in St. Louis. Their findings will be published in the March 1 online early edition issue of the Proceedings of the National Academy of Sciences... (Source: Breast Cancer News From Medical News Today)

Kemper Foundation gives Washington University $3M

bizjournals.com Health Care:Biotechnology headlines — Mon, 01 Mar 2010 22:24:36 +0100

The William T. Kemper Foundation and the Kemper family plan to give $3 million to finance an endowment for the position of director of the Mildred Lane Kemper Art Museum at Washington University and to support the Hope Center for Neurological Disorders at the School of Medicine. (Source: bizjournals.com Health Care:Biotechnology headlines)

Support for the Vascular Depression Hypothesis in Late-Life Depression: Results of a 2-Site, Prospective, Antidepressant Treatment Trial [Original Article]

Archives of General Psychiatry — Mon, 01 Mar 2010 20:50:45 +0100

Conclusions Comprehensive neuropsychological function and white matter hyperintensity severity predicted MADRS scores prospectively over a 12-week treatment course with selective serotonin reuptake inhibitors in late-life depression. Baseline neuropsychological function differentiated remitters from nonremitters and predicted time to remission in a proportional hazards model. Predictor variables correlated highly with vascular risk factor severity. These data support the vascular depression hypothesis and highlight the importance of linking subtypes based on neuropsychological function and white matter integrity. Trial Registration clinicaltrials.gov Identifier: NCT00045773 (Source: Archives of General Psychiatry)

Development and analysis of a germline BAC resource for the sea lamprey, a vertebrate that undergoes substantial chromatin diminution

Chromosoma — Mon, 01 Mar 2010 18:07:55 +0100

Abstract Over the last several years, the sea lamprey (Petromyzon marinus) has grown substantially as a model for understanding the evolutionary fundaments and capacity of vertebrate developmental and genome biology. Recent work on the lamprey genome has resulted in a preliminary assembly of the lamprey genome and led to the realization that nearly all somatic cell lineages undergo extensive programmed rearrangements. Here we describe the development of a bacterial artificial chromosome (BAC) resource for lamprey germline DNA and use sequence information from this resource to probe the subchromosomal structure of the lamprey genome. The arrayed germline BAC library represents ∼10× coverage of the lamprey genome. Analyses of BAC-end sequences reveal that the lamprey genom...

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Study Suggests That Others May Know Us Better Than We Know Ourselves

Health News from Medical News Today — Mon, 01 Mar 2010 08:00:00 +0100

Since at least the days of Socrates, humans have been advised to "know thyself." And through all the years, many, including many personality and social psychologists, have believed the individual is the best judge of his or her own personality. Now a psychologist at Washington University in St. Louis has shown that we are not the know-it-alls that we think we are. Simine Vazire, Ph.D... (Source: Health News from Medical News Today)

Study Suggests That Others May Know Us Better Than We Know Ourselves

Psychology / Psychiatry News From Medical News Today — Mon, 01 Mar 2010 08:00:00 +0100

New subtype of breast cancer responds to targeted drug

EurekAlert! - Medicine and Health — Mon, 01 Mar 2010 05:00:00 +0100

(Washington University School of Medicine) A newly identified cancer biomarker could define a new subtype of breast cancer as well as offer a potential way to treat it, say researchers at Washington University School of Medicine in St. Louis. (Source: EurekAlert! - Medicine and Health)

Super Chicken Vision

Scientific American - Official RSS Feed — Fri, 26 Feb 2010 15:43:08 +0100

Bring home a bucket of fried chicken and you may find that people have strong feelings about which part of the bird is best. Well, scientists at Washington University in St. Louis [led by Joseph Corbo] say the answer is: the eyes. At least when you compare them to our own ocular implements. Because chickens can see more colors than we do, findings that appear in the journal Public Library of Science ONE. [See http://bit.ly/b0LyQT ] [More] (Source: Scientific American - Official RSS Feed)

Adverse Housing and Neighborhood Conditions and Inflammatory Markers among Middle-Aged African Americans

Journal of Urban Health — Fri, 26 Feb 2010 06:46:46 +0100

Abstract Adverse housing and neighborhood conditions are independently associated with an increased risk of various diseases and conditions. One possible explanation relates to systemic inflammation, which is associated with these adverse health outcomes. The authors investigated the association between housing and neighborhood conditions with inflammatory markers using data about 352 persons aged 49–65 years from the African American Health study. Participants were identified by a multistage random selection process in 2000 to 2001(response rate, 76%). Blood was analyzed for soluble cytokine receptors (interleukin-6, tumor necrosis factor α), C-reactive protein, and adiponectin. Neighborhood and housing characteristics consisted of five observed block face conditio...

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Roles of myocardial blood volume and flow in coronary artery disease: an experimental MRI study at rest and during hyperemia

European Radiology — Thu, 25 Feb 2010 06:50:52 +0100

Conclusions MR first-pass perfusion can rapidly estimate regional MBF and MBV. Absolute quantification of MBV may add additional information on stenosis severity and myocardial viability compared with standard qualitative clinical evaluations of myocardial perfusion. Content Type Journal ArticleCategory Magnetic ResonanceDOI 10.1007/s00330-010-1740-8Authors Kyle S. McCommis, Washington University School of Medicine Mallinckrodt Institute of Radiology St. Louis MO USAThomas A. Goldstein, Washington University School of Medicine Mallinckrodt Institute of Radiology St. Louis MO USADana R. Abendschein, Washington University School of Medicine Center for Cardiovascular Research St. Louis MO USABernd Misselwitz, Bayer Schering Pharma AG Berlin GermanyThomas Pilgram, Washin...

Emerging tick-borne disease

EurekAlert! - Medicine and Health — Thu, 25 Feb 2010 05:00:00 +0100

(Washington University in St. Louis) A new assay allows scientists to discover whether ticks are carrying disease-causing bacteria and which animals provided their last blood meal. Assay results suggest three emerging diseases in the St. Louis area are carried by lone star ticks feeding on record-high populations of white tailed deer. (Source: EurekAlert! - Medicine and Health)

Others may know us better than we know ourselves, study finds

EurekAlert! - Social and Behavioral Science — Thu, 25 Feb 2010 05:00:00 +0100

(Washington University in St. Louis) Humans have long been advised to "know thyself," but new research suggests we may not know ourselves as well as we think we do. While individuals may be more accurate at assessing their own neurotic traits, such as anxiety, it seems friends, and even strangers, are often better barometers of traits such as intelligence, creativity and extroversion. (Source: EurekAlert! - Social and Behavioral Science)

Conjugal Parkinsonism and Parkinson disease: A case series with environmental risk factor analysis

Parkinsonism and Related Disorders — Wed, 24 Feb 2010 15:05:09 +0100

Abstract: PD occurring in married couples, “conjugal PD” represents a unique opportunity to study environmental risk factors for PD due to the shared environment. This retrospective study of non-related married individuals who both presented to the Washington University Movement Disorders Center between 1994 and 2005 investigated the clinical presentation, therapy response, and disease course in conjugal PD subjects. In addition, an occupational, residential, and environmental survey was administered to elucidate potential shared environmental risk factors.Eighteen married subjects had a clinical picture suggestive of idiopathic Parkinson disease. Average age of motor symptom onset was 66.1 (±6.22) years in women, 63.4 (±7.87) years in men. Subjects cohabitated an average of 39.9 yea...

Startling New Childhood Asthma Data Released By George Washington University

Health News from Medical News Today — Wed, 24 Feb 2010 08:00:00 +0100

Researchers from The George Washington University, School of Public Health and Health Services (GW) have said that asthma, a largely manageable and chronic disease, is on the rise in America and released new data on the magnitude of the asthma crisis, the surging cost of treatment, and the more than 1 million children with asthma who are uninsured. A new report from GW, Changing pO2licy: The Elements for Improving Childhood Asthma Outcomes, found that asthma adds about 50 cents to every health care dollar spent on children with asthma compared to children without asthma... (Source: Health News from Medical News Today)

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Startling New Childhood Asthma Data Released By George Washington University

Pediatrics News From Medical News Today — Wed, 24 Feb 2010 08:00:00 +0100

Electrophysiological properties of isthmic neurons in frogs revealed by in vitro and in vivo studies

Wed, 24 Feb 2010 06:47:59 +0100

Abstract The frog nucleus isthmi (parabigeminal nucleus in mammals) is a visually responsive, cholinergic and anatomically well-defined group of neurons in the midbrain. It shares reciprocal topographic projections with the ipsilateral optic tectum (superior colliculus in mammals) and strongly influences visual processing. Anatomical and biochemical information indicates the existence of distinct neural populations within the frog nucleus isthmi, which raises the question: are there electrophysiological distinctions between neurons that are putatively classified by their anatomical and biochemical properties? To address this question, we measured frog nucleus isthmi neuron cellular properties in vitro and visual response properties in vivo. No evidence for distinct electro...

Maintained Expression of the Planar Cell Polarity Molecule Vangl2 and Reformation of Hair Cell Orientation in the Regenerating Inner Ear

JARO - Journal of the Association for Research in Otolaryngology — Tue, 23 Feb 2010 07:44:12 +0100

Abstract The avian inner ear possesses a remarkable ability to regenerate sensory hair cells after ototoxic injury. Regenerated hair cells possess phenotypes and innervation that are similar to those found in the undamaged ear, but little is known about the signaling pathways that guide hair cell differentiation during the regenerative process. The aim of the present study was to examine the factors that specify the orientation of hair cell stereocilia bundles during regeneration. Using organ cultures of the chick utricle, we show that hair cells are properly oriented after having regenerated entirely in vitro and that orientation is not affected by surgical removal of the striolar reversal zone. These results suggest that the orientation of regenerating stereocilia is not ...

Stage IV Rectal Cancer with Liver Metastases: Is There a Benefit to Resection of the Primary Tumor?

World Journal of Surgery — Tue, 23 Feb 2010 07:18:48 +0100

Conclusions Current chemotherapeutic regimens lead to improved survival in patients with unresectable liver metastases. Upfront chemotherapy in the asymptomatic patient compared with resection of the primary tumor does not appear to significantly affect survival. However, given that 60% of patients were alive after 2 years, resection of the primary lesion for palliative reasons and local control must be considered. Content Type Journal ArticleDOI 10.1007/s00268-010-0483-7Authors Christina Cellini, Washington University School of Medicine Department of Surgery, Section of Colon and Rectal Surgery Campus Box 8109 St. Louis MO 63110 USASteven R. Hunt, Washington University School of Medicine Department of Surgery, Section of Colon and Rectal Surgery Campus Box 81...

Startling new childhood asthma data

EurekAlert! - Social and Behavioral Science — Tue, 23 Feb 2010 05:00:00 +0100

(The Merck Childhood Asthma Network, Inc.) Researchers from the George Washington University School of Public Health and Health Services said today that asthma, a largely manageable and chronic disease, is on the rise in America and released new data on the magnitude of the asthma crisis, the surging cost of treatment, and the more than 1 million children with asthma who are uninsured. (Source: EurekAlert! - Social and Behavioral Science)

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Continuity of Health Information Award Winners

Midcontinental Region News — Mon, 22 Feb 2010 22:38:23 +0100

The winners of the 2010 NN/LM MidContinental Region Continuity of Health Information Awards are: Washington University School of Medicine, Becker Medical Library: Mobile School Health Information Initiative (MoSHI), Principal Investigators- Will Olmstadt, Bob Engeszer and Judy Hansen. Integrating the Medical Library Into Hospital Emergency Planning, Principal Investigator- Betsy Kelly. Denver Public Library, A Bridge to Health Literacy for Denver- Elaine Connell, Cassi Pretlow and Loretta Spurling. Dykes Library at the University of Kansas Medical Center, Información de Salud para Promotoras, Principal Investigator- Amy Ritterskamp Health Sciences Library, Saint Luke’s Hospital of Kansas City, Hospital Library Advocacy, Principal Investigators- Karen Wiederaenders and ...

Collaboration: Lessons Learned Webinar

Midcontinental Region News — Mon, 22 Feb 2010 19:32:17 +0100

Navigating Collaboration: A Crash Course in Connecting with the Community: Lessons Learned March 22, 1:00 MT/2:00CT Over the past year, a series of webinars has been offered on how to develop and maintain collaborative relationships with people and organizations outside the library http://nnlm.gov/mcr/resources/community/collaboration.html . Each of the webinars included information and resources on that topic area. On March 22, Will Olmstadt, Librarian, Becker Medical Library, Washington University School of Medicine will close out the series with a discussion with “Lessons Learned”. Come listen and contribute to the discussion that offers insight based on experience on what works well when collaborating around health information. Log onto https://webmeeting.nih.gov/siobhan...

Teaching Health Policy to Residents

Journal of General Internal Medicine — Sat, 20 Feb 2010 06:57:05 +0100

Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s11606-010-1268-2Authors Ryan Greysen, Yale Medical School New Haven CT USATravis Wasserman, George Washington University School of Public Health Washington DC USAPerry Payne, George Washington University School of Public Health Washington DC USAFitzhugh Mullan, George Washington University School of Public Health Washington DC USA Journal Journal of General Internal MedicineOnline ISSN 1525-1497Print ISSN 0884-8734 (Source: Journal of General Internal Medicine)

Alvin J. Siteman Cancer Center Summer Opportunities Program

ScanGrants feed — Fri, 19 Feb 2010 00:00:00 +0100

The Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine provides opportunities for undergraduate, pre-med and medical students enrolled at Washington University or other accredited universities to work on cancer research projects during the summer. Opportunities range from basic laboratory research to clinical research to prevention/control and population research.Applicants selected for the program will receive a $3,500 stipend for a 10-week summer research period from June 1 through Aug. 6, 2010, though some flexibility is available. Approximately 12 students will be selected. Please apply online at:http://www2.siteman.wustl.edu/studentsubmission/Home.aspxApplication process:1) an online application form, which requires: * a personal st...

Former Senate Parliamentarian Questions Reconciliation, Senators Want Public Option Back

Health News from Medical News Today — Thu, 18 Feb 2010 13:00:00 +0100

A former Senate parliamentarian said Tuesday that using reconciliation to pass health care reform will be difficult because the procedure wasn't meant to make policy, Politico's Live Pulse blog reports. The former parliamentarian, Robert Dove, who now teaches at George Washington University, said there are many things that cannot be put into the reconciliation bill. "Dove would know. In 1974, in the midst of his 36-year Senate career, he helped design the Congressional Budget Act, which first created the rules for reconciliation... (Source: Health News from Medical News Today)

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Recombinant human bone morphogenetic protein 2-induced heterotopic ossification of the retroperitoneum, psoas muscle, pelvis and abdominal wall following lumbar spinal fusion

Skeletal Radiology — Wed, 17 Feb 2010 07:26:30 +0100

Abstract A 45-year-old man presented with vertebral collapse at L5 as an initial manifestation of multiple myeloma and underwent spinal fusion surgery using recombinant human bone morphogenetic protein-2 (rhBMP-2). Subsequent computed tomography (CT) scans and X-rays revealed heterotopic ossification of the left psoas muscle, pelvis, and anterior abdominal wall. While the occurrence of heterotopic ossification has previously been reported when rhBMP-2 has been used for spinal fusion surgery, this case demonstrates that it can occur to a much greater degree than previously seen. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00256-010-0890-8Authors Raj K. Shah, The George Washington University School of Medicine 2300 Eye Street NW Washington DC 20037 USAV...

RTOG names Bradley as new lung cancer chair

Health Imaging News — Tue, 16 Feb 2010 20:07:23 +0100

The Radiation Therapy Oncology Group (RTOG) has appointed a new lung cancer committee chair, Jeffrey Bradley, MD, associate professor of radiation oncology at the Washington University School of Medicine in St. Louis. (Source: Health Imaging News)

RTOG names Bradley as new lung cancer chair

Health Imaging News — Tue, 16 Feb 2010 20:07:23 +0100

News From The Journal Of Clinical Investigation: Feb. 15, 2010

Health News from Medical News Today — Tue, 16 Feb 2010 10:00:00 +0100

DEVELOPMENT: Deciphering the role of the protein RET in development Several diseases and developmental defects, including Hirschsprung disease and congenital anomalies of kidneys or urinary tract (CAKUT) syndrome, are caused by mutations in the RET gene. It is not clear, however, how RET gene mutations lead to such a range of diseases, which can occur in isolation or combination. Insight into this issue has now been provided by Sanjay Jain and colleagues, at Washington University School of Medicine, St. Louis, through their analysis of ten strains of RET mutant mice... (Source: Health News from Medical News Today)

Foreword

Current Problems in Surgery — Mon, 15 Feb 2010 15:24:52 +0100

More than 20,000 pediatric cardiac operations are performed per year in the United States for congenital and acquired heart disease. The perioperative care of these patients is incredibly complex and requires the coordinated efforts of a sophisticated multidisciplinary team and state-of-the-art facilities and equipment. In this and the next issue of Current Problems in Surgery, Drs. Avihu Gazit, Charles Huddleston, Paul Checchia, James Fehr, and A. Thomas Pezzella from Washington University in St. Louis have written an insightful monograph entitled, “Care of the Pediatric Cardiac Surgery Patient.” This issue, Part 1, introduces the subject, outlining the state of the problem, pathogenesis, and pathophysiology. This is followed by a detailed discussion of the preoperative and operative ...

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Chickens 'one-up' humans in ability to see color

EurekAlert! - Medicine and Health — Mon, 15 Feb 2010 05:00:00 +0100

(Washington University School of Medicine) Researchers at Washington University School of Medicine in St. Louis have peered deep into the eye of the chicken and found a masterpiece of biological design. Scientists mapped five types of light receptors in the chicken's eye. They discovered the receptors were laid out in interwoven mosaics that maximized the chicken's ability to see many colors in any given part of the retina, the light-sensing structure at the back of the eye. (Source: EurekAlert! - Medicine and Health)

Call for Nominations for 2010 National Academies Communication Awards

ScanGrants feed — Mon, 15 Feb 2010 00:00:00 +0100

The IOM, in conjunction with the National Academy of Science and the National Academy of Engineering, is accepting nominations for the 2010 National Academies Communication Awards. This award recognizes excellence in reporting and communicating science, engineering, and medicine to the public in 2009. A $20,000 prize is awarded in each of four categories for communication through books; newspapers or magazines; the internet; and TV, radio, or film.Nominations must be completed online and all supporting material postmarked no later than April 14, 2010. The winners will be honored during the National Academies Keck Futures Initiative Conference, held November 16-19 in Irvine, California. Information on eligibility, submission requirements, and nomination procedures is available at the Keck F...

Parents Often Wait Too Long To Treat Children's Asthma Symptoms

Pediatrics News From Medical News Today — Fri, 12 Feb 2010 11:00:00 +0100

Parents Often Wait Too Long To Treat Children's Asthma Symptoms

Health News from Medical News Today — Fri, 12 Feb 2010 11:00:00 +0100

Parents of young children with asthma often recognize signs that their child is about to have an asthma attack but delay home treatment until the attack occurs, researchers at Washington University School of Medicine in St. Louis report. Results of the study, published in the Annals of Allergy, Asthma and Immunology, show there are missed opportunities to intervene early and thus relieve a child's symptoms, possibly reduce the extent of the attack and prevent visits to the emergency room... (Source: Health News from Medical News Today)

Noted Surgeons Give High Marks to Viking Systems' "Next Gen" 3D System in Clinical Evaluation

Medical News (via PRIMEZONE) — Thu, 11 Feb 2010 12:00:00 +0100

WESTBOROUGH, Mass., Feb. 11, 2010 (GLOBE NEWSWIRE) -- Viking Systems announced today that it recently successfully completed the first evaluation of its "Next Generation" 3DHD prototype visualization system. The laboratory session was conducted at the Washington University School of Medicine's Institute for Minimally Invasive Surgery in St. Louis, MO. Gerald L. Andriole, MD, Professor and Chief of Urologic Surgery at Washington University and Sam Bhayani, MD, Assistant Professor of Urologic Surgery and Co-Director of Robotic Surgery, Washington University were the surgeon participants. (Source: Medical News (via PRIMEZONE))

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Parents often wait too long to treat children's asthma symptoms

EurekAlert! - Medicine and Health — Thu, 11 Feb 2010 05:00:00 +0100

(Washington University School of Medicine) Parents of young children with asthma often recognize signs that their child is about to have an asthma attack but delay home treatment until the attack occurs, researchers at Washington University School of Medicine in St. Louis report. (Source: EurekAlert! - Medicine and Health)

New Way Found To Kill Pediatric Brain Tumors

Health News from Medical News Today — Wed, 10 Feb 2010 11:00:00 +0100

Researchers at Washington University School of Medicine in St. Louis have shown once again that "ready, fire, aim," nonsensical though it may sound, can be an essential approach to research. The scientists robotically "fired" 2,000 compounds into culture plates containing tumor cells to see if the compounds had any effect. When the robotic screener found one substance had scored a hit by inhibiting growth of the tumor cells in its plate, researchers analyzed what that compound acted against... (Source: Health News from Medical News Today)

New Way Found To Kill Pediatric Brain Tumors

Pediatrics News From Medical News Today — Wed, 10 Feb 2010 11:00:00 +0100

A phase 1, multicenter, open-label study of the safety of two dose levels of a human monoclonal antibody to human αv integrins, intetumumab, in combination with docetaxel and prednisone in patients with castrate-resistant metastatic prostate cancer

Investigational New Drugs — Wed, 10 Feb 2010 06:48:14 +0100

Conclusions Intetumumab was generally safe and well tolerated in combination with docetaxel, with a higher incidence of TEAEs in the 10 mg/kg dose cohort. The efficacy of 10 mg/kg intetumumab in combination with docetaxel appears to warrant further study. Content Type Journal ArticleCategory PHASE I STUDIESDOI 10.1007/s10637-010-9388-4Authors Franklin M. Chu, San Bernardino Urological Associates Medical Group San Bernardino CA USAJoel Picus, Washington University School of Medicine Alvin J. Siteman Cancer Center St. Louis MO USAPaula M. Fracasso, Washington University School of Medicine Alvin J. Siteman Cancer Center St. Louis MO USARobert Dreicer, Cleveland Clinic Cleveland OH USAZhihui Lang, Centocor Research and Development, Inc Malvern PA USABrenda Foster, Centocor Rese...

Thyroid Medication Use and Subsequent Development of Dementia of the Alzheimer Type

Journal of Geriatric Psychiatry and Neurology — Wed, 10 Feb 2010 00:37:54 +0100

We examined data from participants enrolled in longitudinal studies at the Washington University Alzheimer’s Disease Research Center for associations between thyroid disease, thyroid hormone supplementation therapy, and subsequent development of dementia of the Alzheimer type (DAT). Data collected between April 1992 and June 2008 from 499 participants, 184 men and 315 women, were analyzed. Mean age was 76.9 years (SD = 9.2). At baseline, 61 participants reported thyroid medication use and 87 were identified as having a history of thyroid dysfunction. These participants progressed to a DAT diagnosis more rapidly than individuals not taking thyroid medication (hazard ratios [HR]: 1.67, 95% CI: 0.99-2.78, P = .054). Although an interesting trend was seen, baseline thyroid disease was no...

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Suppression of lysyl oxidase gene expression by methylation in pelvic organ prolapse

International Urogynecology Journal — Tue, 09 Feb 2010 17:34:20 +0100

Conclusions Methylation in the promoter region may suppress LOX gene expression in women with pelvic organ prolapse. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00192-010-1108-2Authors John Klutke, USC Keck School of Medicine Department of Obstetrics and Gynecology Los Angeles CA USAFrank Z. Stanczyk, USC Keck School of Medicine Department of Obstetrics and Gynecology Los Angeles CA USAQing Ji, Baylor University School of Medicine Houston TX USAJoseph David Campeau, USC Keck School of Medicine Department of Obstetrics and Gynecology Los Angeles CA USACarl Georg Klutke, Washington University School of Medicine Department of Urology St. Louis MO USA Journal International Urogynecology JournalOnline ISSN 1433-3023Print ISSN 0937-3462 (Source: I...

Antibodies From Plants May Help Fight Disease

Health News from Medical News Today — Tue, 09 Feb 2010 08:00:00 +0100

The first head-to-head comparison of therapeutic monoclonal antibodies produced from plants versus the same antibodies produced from mammalian cells has shown that plant-produced antibodies can fight infection equally well. Scientists from Washington University School of Medicine in St. Louis and Arizona State University conducted the comparison as a test of the potential for treating disease in developing nations with the significantly less expensive plant-based production technique. The results are reported online in the Proceedings of the National Academy of Sciences... (Source: Health News from Medical News Today)

Antibodies From Plants May Help Fight Disease

Immune System / Vaccines News From Medical News Today — Tue, 09 Feb 2010 08:00:00 +0100

Researchers discover new way to kill pediatric brain tumors

EurekAlert! - Medicine and Health — Tue, 09 Feb 2010 05:00:00 +0100

(Washington University School of Medicine) Researchers have identified a previously unrecognized target, a protein called STAT3, at which they can aim new drugs for the treatment of cancer in neurofibromatosis-1 (NF1), a genetic condition that causes increased risk of benign and malignant brain tumors. (Source: EurekAlert! - Medicine and Health)

Higher Risk Of Stillbirth In Women With Fibroids

Health News from Medical News Today — Mon, 08 Feb 2010 08:00:00 +0100

In a study presented at the Society for Maternal-Fetal Medicine's (SMFM) annual meeting, The Pregnancy Meeting™ in Chicago, researchers unveiled findings that show that there is an increased risk of intrauterine fetal death (IUFD), commonly known as stillbirth, in women who have fibroids. IUFD, or still birth, is rare and affects only six to seven out of every thousand births. The study, conducted by researchers at Washington University in St. Louis, Mo., identified women who had fibroids detected during their routine second trimester ultrasound for anatomic survey at 16-22 weeks... (Source: Health News from Medical News Today)

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Percent microscopic tumor necrosis and survival after curative surgery for renal cell carcinoma ...

UroToday — Sun, 07 Feb 2010 23:00:00 +0100

Divisions of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri. (Source: UroToday)

Exclusion of Malignancy in Thyroid Nodules with Indeterminate Fine-Needle Aspiration Cytology After Negative 18F-Fluorodeoxyglucose Positron Emission Tomography: Interim Analysis

World Journal of Surgery — Sat, 06 Feb 2010 08:17:55 +0100

Conclusions Based on these preliminary data, FDG-PET may have a role in excluding malignancy in thyroid nodules with an indeterminate FNA biopsy. This finding justifies ongoing accrual to our target population of 125 participants. Content Type Journal ArticleDOI 10.1007/s00268-010-0398-3Authors Amber L. Traugott, Washington University School of Medicine Department of Surgery 660 South Euclid Avenue St. Louis MO 63110 USAFarrokh Dehdashti, Washington University School of Medicine Department of Radiology, Mallinckrodt Institute of Radiology 510 S. Kingshighway St. Louis MO 63110 USAKathryn Trinkaus, Washington University School of Medicine Department of Biostatistics 660 South Euclid Avenue St. Louis MO 63110 USAMark Cohen, University of Kansas School of Medicine Departm...

Researcher Awarded $2 Million To Tackle Elephantiasis, River Blindness

Health News from Medical News Today — Sat, 06 Feb 2010 08:00:00 +0100

In an effort to eliminate the tropical diseases elephantiasis and river blindness, a Michigan State University researcher has been awarded $2 million to reformulate an existing drug that could stop the debilitating diseases in their tracks. Charles Mackenzie, a professor of veterinary pathology in the College of Veterinary Medicine, was awarded the funding via a larger $13 million grant the Washington University School of Medicine in St. Louis received from the Bill & Melinda Gates Foundation... (Source: Health News from Medical News Today)

Infection-fighting antibodies made in plants as effective as costlier conventional version

EurekAlert! - Infectious and Emerging Diseases — Fri, 05 Feb 2010 05:00:00 +0100

(Washington University School of Medicine) The first head-to-head comparison of therapeutic monoclonal antibodies produced from plants versus the same antibodies produced from mammalian cells has shown that plant-produced antibodies can fight infection equally well. Scientists conducted the comparison as a test of the potential for treating disease in developing nations with the significantly less expensive plant-based production technique. (Source: EurekAlert! - Infectious and Emerging Diseases)

Intra-individual variation in serum C-reactive protein over 4 years: an implication for epidemiologic studies

Cancer Causes and Control — Thu, 04 Feb 2010 18:13:21 +0100

Conclusion Investigators planning to measure hsCRP only once should design adequately sized studies to preserve inferences for hypothesized modest to moderate RRs. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-010-9511-zAuthors Elizabeth A. Platz, Johns Hopkins Bloomberg School of Public Health Department of Epidemiology 615 N. Wolfe St., Rm E6132 Baltimore MD 21205 USASiobhan Sutcliffe, Washington University School of Medicine Alvin J. Siteman Cancer Center and the Department of Surgery St. Louis MO USAAngelo M. De Marzo, Johns Hopkins Medical Institutions James Buchanan Brady Urological Institute Baltimore MD USACharles G. Drake, Johns Hopkins Medical Institutions Sidney Kimmel Comprehensive Cancer Center Baltimore MD USANader Rifai, Children...

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Evaluation of artificial sweat in athletes with spinal cord injuries

European Journal of Applied Physiology — Thu, 04 Feb 2010 18:10:17 +0100

In conclusion, the application of artificial sweat via SB was ineffective in attenuating the onset of uncompensable heat strain during high-intensity arm exercise in a comfortable environment. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00421-010-1371-4Authors R. C. Pritchett, Central Washington University Department of Nutrition, Exercise and Health Sciences 400 East University Way Ellensburg WA 98923 USAP. A. Bishop, The University of Alabama Department of Kinesiology Tuscaloosa AL 35487 USAZ. Yang, The University of Alabama Department of Kinesiology Tuscaloosa AL 35487 USAK. L. Pritchett, Central Washington University Department of Nutrition, Exercise and Health Sciences 400 East University Way Ellensburg WA 98923 USAJ. M. Green, The University of North Alaba...

Ideal Target For Malaria Therapy Discovered By Scientists

Health News from Medical News Today — Thu, 04 Feb 2010 12:00:00 +0100

Scientists at Washington University School of Medicine in St. Louis have identified a protein made by the malaria parasite that is essential to its ability to take over human red blood cells. Malaria, which is spread by mosquito bites, kills between 1 million and 3 million people annually in Third World countries. Death results from damage to red blood cells and clogging of the capillaries that feed the brain and other organs. "The malaria parasite seizes control of and remodels the red blood cell by secreting hundreds of proteins once it's inside," says Dan Goldberg, M.D., Ph.D... (Source: Health News from Medical News Today)

Ideal Target For Malaria Therapy Discovered By Scientists

Biology / Biochemistry News From Medical News Today — Thu, 04 Feb 2010 12:00:00 +0100

Gene variation makes alcoholism less likely in some

Medicineworld.org: New Article Alert — Wed, 03 Feb 2010 14:04:47 +0100

Exposure to severe stress early in life increases the risk of alcohol and drug addiction. Yet surprisingly, some adults sexually abused as children - and therefore at high risk for alcohol problems - carry gene variants that protect them from heavy drinking and its effects, as per scientists at Washington University School of Medicine in St. Louis........ (Source: Medicineworld.org: New Article Alert)

Growth Factor Gene Shown To Be A Key To Cleft Palate

Health News from Medical News Today — Wed, 03 Feb 2010 11:00:00 +0100

Cleft palate has been linked to dozens of genes. During their investigation of one of these genes, researchers at Washington University School of Medicine in St. Louis were surprised to find that cleft palate occurs both when the gene is more active and when it is less active than normal. They say the finding suggests this gene and processes closely associated with it are central to palate development and could become important targets for investigators seeking nonsurgical treatments to prevent cleft palate before birth... (Source: Health News from Medical News Today)

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Growth Factor Gene Shown To Be A Key To Cleft Palate

Genetics News From Medical News Today — Wed, 03 Feb 2010 11:00:00 +0100

Growth Factor Gene Shown To Be A Key To Cleft Palate

Cleft Palate News From Medical News Today — Wed, 03 Feb 2010 10:00:00 +0100

Gene Variation Makes Alcoholism Less Likely In Some Survivors Of Sexual Abuse

Health News from Medical News Today — Wed, 03 Feb 2010 10:00:00 +0100

Exposure to severe stress early in life increases the risk of alcohol and drug addiction. Yet surprisingly, some adults sexually abused as children - and therefore at high risk for alcohol problems - carry gene variants that protect them from heavy drinking and its effects, according to researchers at Washington University School of Medicine in St. Louis... (Source: Health News from Medical News Today)

Growth Factor Gene Shown To Be A Key To Cleft Palate

Health News from Medical News Today — Wed, 03 Feb 2010 10:00:00 +0100

Gene Variation Makes Alcoholism Less Likely In Some Survivors Of Sexual Abuse

Genetics News From Medical News Today — Wed, 03 Feb 2010 10:00:00 +0100

Exposure to severe stress early in life increases the risk of alcohol and drug addiction. Yet surprisingly, some adults sexually abused as children - and therefore at high risk for alcohol problems - carry gene variants that protect them from heavy drinking and its effects, according to researchers at Washington University School of Medicine in St. Louis... (Source: Genetics News From Medical News Today)

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Genetic variants in the ADD1 and GNB3 genes and blood pressure response to potassium supplementation

Frontiers of Medicine in China — Wed, 03 Feb 2010 06:56:05 +0100

This study was designed to examine the association between 12 single nucleotide polymorphisms (SNPs) in the adducin 1 alpha (ADD1) and guanine nucleotide binding protein (G protein) beta polypeptide 3 (GNB3) genes and systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP) responses to potassium-supplementation. We conducted a 7-day high-sodium intervention (307.8 mmol sodium/day) followed by a 7-day high-sodium with potassium-supplementation (60 mmol potassium/day) among 1906 Han Chinese participants from rural north China. BP measurements were obtained at the end of each intervention period using a random-zero sphygmomanometer. We identified significant associations between ADD1 variant rs17833172 and SBP, DBP, and MAP responses to potassium-supplementation (all P ...

Scientists find ideal target for malaria therapy

EurekAlert! - Medicine and Health — Wed, 03 Feb 2010 05:00:00 +0100

(Washington University School of Medicine) Scientists at Washington University School of Medicine in St. Louis have identified a protein made by the malaria parasite that is essential to its ability to take over human red blood cells. (Source: EurekAlert! - Medicine and Health)

Flu vaccination rate at large, Midwest health system rises dramatically due to mandatory policy

EurekAlert! - Medicine and Health — Wed, 03 Feb 2010 05:00:00 +0100

(Washington University School of Medicine) Making flu shots mandatory in 2008 dramatically increased the vaccination rate among St. Louis-based BJC HealthCare's nearly 26,000 employees to more than 98 percent, according to a report now online in the journal Clinical Infectious Diseases. (Source: EurekAlert! - Medicine and Health)

Hepatitis C and Autoimmune Hepatitis: What Gets Treated First?

Current Hepatitis Reports — Tue, 02 Feb 2010 07:01:00 +0100

Abstract The coexistence of chronic hepatitis C (CHC) and autoimmune hepatitis (AIH) creates a clinical dilemma. Histologic features may suggest the predominance of one versus the other. Nevertheless, histologic differences are not absolute. Immunosuppressive therapy may be used as frontline treatment for patients with predominant histologic features of AIH. In the absence of clinical and biochemical improvement, interferon should not be withheld and a trial of antiviral therapy should be considered. Interferon can be frontline therapy for patients with the overlap syndrome, if histologic features of CHC predominate, a low titer of autoantibodies is present, and coexistent autoimmune diseases are absent. No matter what treatment is offered, close monitoring during the cour...

Gene variation makes alcoholism less likely in some survivors of sexual abuse

EurekAlert! - Social and Behavioral Science — Tue, 02 Feb 2010 05:00:00 +0100

(Washington University in St. Louis) Exposure to severe stress early in life increases the risk of alcohol and drug addiction. Yet surprisingly, some adults sexually abused as children -- and therefore at high risk for alcohol problems -- carry gene variants that protect them from heavy drinking and its effects, according to researchers at Washington University School of Medicine in St. Louis. (Source: EurekAlert! - Social and Behavioral Science)

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Growth factor gene shown to be a key to cleft palate

EurekAlert! - Medicine and Health — Tue, 02 Feb 2010 05:00:00 +0100

(Washington University in St. Louis) Cleft palate has been linked to dozens of genes. During their investigation of one of these genes, researchers at Washington University School of Medicine in St. Louis were surprised to find that cleft palate occurs both when the gene is more active and when it is less active than normal. (Source: EurekAlert! - Medicine and Health)

The Development of the Feighner Criteria: A Historical Perspective [Reviews and Overviews]

Am J Psychiatry — Mon, 01 Feb 2010 19:01:27 +0100

This essay outlines the historical context in which the Feighner criteria emerged; reconstructs, as far as possible, the process by which the criteria were developed; and traces the influence the criteria had on subsequent developments in American psychiatry. In the 1950s, when American psychiatry under psychoanalytic dominance had little interest in psychiatric diagnosis, Edwin Gildea recruited to the Department of Psychiatry at Washington University faculty who advocated a medical model for psychiatry in which diagnosis had a central role. In 1967, at the urging of the then-resident John Feighner, a discussion group led by Eli Robins and including Sam Guze, George Winokur, Robert Woodruff, and Rod Muñoz began meeting with the initial goal of writing a review of prior key contribut...

Id2 deficiency promotes metastasis in a mouse model of ocular cancer

Clinical and Experimental Metastasis — Mon, 01 Feb 2010 18:05:12 +0100

Abstract The inhibitor of DNA binding 2 (Id2) basic helix-loop-helix protein interacts genetically and physically with the pocket proteins (Rb, p107 and p130) and has been implicated as an oncogene. In other studies, however, Id2 has been shown to function as a tumor suppressor. Here, we studied the role of Id2 in a well characterized model of ocular cancer in which the three pocket proteins are inactivated by generating mice lacking one or both Id2 alleles. Id2 deficiency had no impact on tumorigenesis in the eye. Unexpectedly, however, Id2 loss significantly increased the rate of metastasis. Liver metastases in Id2 heterozygotes demonstrated significant decrease of Id2 expression and loss of the remaining Id2 allele, strongly suggesting that Id2 inactivation specifically w...

Important Advance In Imaging Of Cell Death

Health News from Medical News Today — Mon, 01 Feb 2010 09:00:00 +0100

For quite some time, the "Holy Grail" in medical imaging has been the development of an effective method to image cell death as a means to intervene early in diseases and rapidly determine the effectiveness of treatments. A new paper by researchers at the University of Notre Dame and the Washington University School of Medicine describes important progress in using a synthetic probe to target dead and dying cells in mammary and prostate tumors in living animals. Bradley D. Smith, Emil T... (Source: Health News from Medical News Today)

Erratum

Facial Plastic Surgery Clinics of North America — Mon, 01 Feb 2010 00:00:00 +0100

In the November 2009 issue of Facial Plastic Surgery Clinics of North America on facelift, Dr David A. Caplin's affiliations were incorrectly published. Dr Caplin is Clinical Instructor at Washington University, St Louis, and in private practice at Parkcrest Plastic Surgery, 845 North New Ballas Court, Suite 300, St Louis, MO 63141, USA. His e-mail address is: Gfts27@aol.com. (Source: Facial Plastic Surgery Clinics of North America)

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Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

Human Genetics — Fri, 29 Jan 2010 12:15:38 +0100

Abstract Multiple sclerosis (MS) is characterized as an autoimmune demyelinating disease. Numerous family studies have confirmed a strong genetic component underlying its etiology. After several decades of frustrating research, the advent and application of affordable genotyping of dense SNP maps in large data sets has ushered in a new era in which rapid progress is being made in our understanding of the genetics underlying many complex traits. For MS, one of the first discoveries to emerge in this new era was the association with rs6897932[T244I] in the interleukin-7 receptor alpha chain (IL7RA) gene (Gregory et al. in Nat Genet 39(9):1083–1091, 2007; International Multiple Sclerosis Genetics Consortium in N Engl J Med 357(9):851–862, 2007; Lundmark in Nat Genet 39(9):1...

New paper describes important advance in imaging of cell death

EurekAlert! - Medicine and Health — Fri, 29 Jan 2010 05:00:00 +0100

(University of Notre Dame) A new paper by researchers at the University of Notre Dame and Washington University School of Medicine describes important progress in using a synthetic probe to target dead and dying cells in mammary and prostate tumors in living animals (Source: EurekAlert! - Medicine and Health)

Antibiotic Found To Protect Hearing In Mice

Health News from Medical News Today — Thu, 28 Jan 2010 10:00:00 +0100

A type of antibiotic that can cause hearing loss in people has been found to paradoxically protect the ears when given in extended low doses in very young mice. The surprise finding came from researchers at Washington University School of Medicine in St. Louis who looked to see if loud noise and the antibiotic kanamycin together would produce a bigger hearing loss than either factor by itself. The results will appear in an upcoming issue of the Journal of the Association for Research in Otolaryngology and are now available online... (Source: Health News from Medical News Today)

Antibiotic Found To Protect Hearing In Mice

Ear, Nose and Throat News From Medical News Today — Thu, 28 Jan 2010 10:00:00 +0100

A type of antibiotic that can cause hearing loss in people has been found to paradoxically protect the ears when given in extended low doses in very young mice. The surprise finding came from researchers at Washington University School of Medicine in St. Louis who looked to see if loud noise and the antibiotic kanamycin together would produce a bigger hearing loss than either factor by itself... (Source: Ear, Nose and Throat News From Medical News Today)

Clinical predictors of operative complexity in laparoscopic ventral hernia repair: a prospective study

Surgical Endoscopy — Thu, 28 Jan 2010 07:01:11 +0100

Conclusions At least 10 preoperatively identifiable patient variables, either alone or in combination, are predictive of prolonged operative times during laparoscopic ventral hernia repair and may be used as surrogates to determine the complexity of a minimally invasive approach. Content Type Journal ArticleDOI 10.1007/s00464-009-0863-yAuthors Eric D. Jenkins, Washington University School of Medicine Department of Surgery 660 South Euclid Avenue, Campus Box #8109 St. Louis MO 63110 USAVictoria H. Yom, Washington University School of Medicine Department of Surgery 660 South Euclid Avenue, Campus Box #8109 St. Louis MO 63110 USALora Melman, Washington University School of Medicine Department of Surgery 660 South Euclid Avenue, Campus Box #8109 St. Louis MO 63110 USARich...

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Number of Sexual Partners and Associations with Initiation and Intensity of Substance Use

AIDS and Behavior — Wed, 27 Jan 2010 20:34:36 +0100

Abstract We dissected associations between initiation and intensity of substance use and number of sexual partners using pooled data from high school seniors (weighted n = 13,580) who participated in the 1999–2007 Youth Risk Behavior Surveillance System (YRBS), a cross-sectional, nationally representative survey. In multinomial multivariable logistic regressions, number of sexual partners steadily increased as substance use intensified from never use to experimental/new user to heavy use across all substances for both male and females. Severity of substance use is more closely related to, and thus a better indicator of, higher number of sexual partners than age of substance use onset. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s10461-010-966...

US Parkinson's rates highest in whites, Hispanics, and Midwest, Northeast

EurekAlert! - Medicine and Health — Wed, 27 Jan 2010 05:00:00 +0100

(Washington University School of Medicine) The largest epidemiological study of Parkinson's disease in the United States has found that the disease is more common in the Midwest and the Northeast and is twice as likely to strike whites and Hispanics as blacks and Asians. The study is based on data from 36 million Medicare recipients. (Source: EurekAlert! - Medicine and Health)

Antibiotic found to protect hearing in mice

EurekAlert! - Social and Behavioral Science — Wed, 27 Jan 2010 05:00:00 +0100

(Washington University School of Medicine) A type of antibiotic that can cause hearing loss in people has been found to paradoxically protect the ears when given in extended low doses in very young mice. The surprise finding came from researchers at Washington University School of Medicine in St. Louis who looked to see if loud noise and the antibiotic kanamycin together would produce a bigger hearing loss than either factor by itself. (Source: EurekAlert! - Social and Behavioral Science)

St. Jude Children's Research Hospital And Washington University Team To Unravel Genetic Basis Of Childhood Cancers

Health News from Medical News Today — Tue, 26 Jan 2010 09:00:00 +0100

St. Jude Children's Research Hospital and Washington University School of Medicine in St. Louis, announced an unprecedented effort to identify the genetic changes that give rise to some of the world's deadliest childhood cancers. The team has joined forces to decode the genomes of more than 600 childhood cancer patients treated at St. Jude, who have contributed tumor samples for this historic effort. The St... (Source: Health News from Medical News Today)

St. Jude Children's Research Hospital And Washington University Team To Unravel Genetic Basis Of Childhood Cancers

Cancer / Oncology News From Medical News Today — Tue, 26 Jan 2010 09:00:00 +0100

St. Jude Children's Research Hospital and Washington University School of Medicine in St. Louis, announced an unprecedented effort to identify the genetic changes that give rise to some of the world's deadliest childhood cancers. The team has joined forces to decode the genomes of more than 600 childhood cancer patients treated at St... (Source: Cancer / Oncology News From Medical News Today)

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St. Jude Children's Research Hospital And Washington University Team To Unravel Genetic Basis Of Childhood Cancers

Health News from Medical News Today — Tue, 26 Jan 2010 08:00:00 +0100

St. Jude Children's Research Hospital and Washington University School of Medicine in St. Louis, today announced an unprecedented effort to identify the genetic changes that give rise to some of the world's deadliest childhood cancers. The team has joined forces to decode the genomes of more than 600 childhood cancer patients treated at St. Jude, who have contributed tumor samples for this historic effort. The St... (Source: Health News from Medical News Today)

St. Jude Children's Research Hospital And Washington University Team To Unravel Genetic Basis Of Childhood Cancers

Cancer / Oncology News From Medical News Today — Tue, 26 Jan 2010 08:00:00 +0100

St. Jude Children's Research Hospital and Washington University School of Medicine in St. Louis, today announced an unprecedented effort to identify the genetic changes that give rise to some of the world's deadliest childhood cancers. The team has joined forces to decode the genomes of more than 600 childhood cancer patients treated at St... (Source: Cancer / Oncology News From Medical News Today)

St. Louis philanthropist commits to $1 million annual endowment for cancer research

OrlandoSentinel: Medical Research — Tue, 26 Jan 2010 02:02:00 +0100

ST. LOUIS (AP) — A St. Louis philanthropist has committed to endow a cancer center at Washington University with $1 million a year. The Alvin J. Siteman Cancer Research Fund will support work in cancer prevention, diagnosis and treatment. In 1999,... (Source: OrlandoSentinel: Medical Research)

St. Louis Could Be Hub In Cure For Cancer

OrlandoSentinel: Medical Research — Tue, 26 Jan 2010 00:00:00 +0100

Research is underway in St. Louis that could change everything for kids with cancer and their families. It is a $65 million joint project between St. Jude's Childrens' Hospital in Memphis and Washington University School of Medicine in St. Louis. The... (Source: OrlandoSentinel: Medical Research)

Washington U., St. Jude team on $65M pediatric cancer genome project

bizjournals.com Health Care:Biotechnology headlines — Mon, 25 Jan 2010 15:00:08 +0100

Washington University School of Medicine in St. Louis and St. Jude Children’s Hospital in Memphis are teaming up to sequence the genomes of 600 children with pediatric cancer in the hope of identifying the genetic changes that cause some of the world’s deadliest childhood cancers. (Source: bizjournals.com Health Care:Biotechnology headlines)

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St. Jude and Washington University team to unravel genetic basis of childhood cancers

EurekAlert! - Medicine and Health — Mon, 25 Jan 2010 05:00:00 +0100

(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital and Washington University School of Medicine in St. Louis, today announced an unprecedented effort to identify the genetic changes that give rise to some of the world's deadliest childhood cancers. The team has joined forces to decode the genomes of more than 600 childhood cancer patients treated at St. Jude, who have contributed tumor samples for this historic effort. (Source: EurekAlert! - Medicine and Health)

St. Jude Children’s Research Hospital and Washington University team to unravel genetic basis of childhood cancers

St. Jude Children's Research Hospital — Mon, 25 Jan 2010 00:00:00 +0100

St. Jude Children’s Research Hospital and Washington University School of Medicine in St. Louis, today announced an unprecedented effort to identify the genetic changes that give rise to some of the world’s deadliest childhood cancers. The team has joined forces to decode the genomes of more than 600 childhood cancer patients who have contributed tumor samples for this historic effort. (Source: St. Jude Children's Research Hospital)

St. Jude Children’s Research Hospital and Washington University team to unravel genetic basis of childhood cancers

St. Jude Children's Research Hospital — Mon, 25 Jan 2010 00:00:00 +0100

Book: Brain: The Complete Mind

Sound Medicine — Sun, 24 Jan 2010 00:00:00 +0100

When you think of the National Geographic, visions of Mount Kilimanjaro come to mind. Or maybe gazelles leaping across the savanna. A new book explores an even more complex landscape: the brain. Today Barbara Lewis speaks with Dr. Richard Restak, neuroscientist at George Washington University Medical Center. He oversaw production of a new National Geographic book titled Brain: The Com.... (Source: Sound Medicine)

Breast Cancer and Social Interactions: Identifying Multiple Environments that Regulate Gene Expression

Videocast - All Events — Fri, 22 Jan 2010 21:26:00 +0100

Presented by: Sarah J. Gehlert, PhD, Washington University in St. LouisCategory: BSSR Lecture SeriesAired date: 12/17/2009 (Source: Videocast - All Events)

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Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin

JARO - Journal of the Association for Research in Otolaryngology — Fri, 22 Jan 2010 10:10:06 +0100

Abstract Animal studies indicate that a combination of kanamycin (KM) and noise produces a synergistic effect, whereby the threshold shift from the combination is greater than the sum of the shifts caused by either agent alone. Most such studies have focused on adult animals, and it has remained unclear whether younger, presumably more susceptible, animals show an even greater synergistic effect. The present study tested the hypothesis that young CBA/J mice receiving a low dose of KM (300 mg/kg, 2×/day, s.c.) from 20 to 30 days post-gestational age followed by brief noise exposure (110 dB SPL; 4–45 kHz, 30 s) would show greater noise-induced permanent threshold shifts (NIPTS) than mice receiving either treatment alone. Noise exposure produced 30�...

HIV Infection Prematurely Ages The Brain

Health News from Medical News Today — Fri, 22 Jan 2010 10:00:00 +0100

HIV infection or the treatments used to control it are prematurely aging the brain, researchers at Washington University School of Medicine in St. Louis and the University of California-San Diego have found. Blood flow in the brains of HIV patients is reduced to levels normally seen in uninfected patients 15 to 20 years older, scientists report online in The Journal of Infectious Diseases. "The graying of the AIDS patient community makes this infection's effects on the brain a significant source of concern," says first author Beau Ances, M.D., Ph.D... (Source: Health News from Medical News Today)

HIV Infection Prematurely Ages The Brain

HIV / AIDS News From Medical News Today — Fri, 22 Jan 2010 10:00:00 +0100

HIV infection or the treatments used to control it are prematurely aging the brain, researchers at Washington University School of Medicine in St. Louis and the University of California-San Diego have found. Blood flow in the brains of HIV patients is reduced to levels normally seen in uninfected patients 15 to 20 years older, scientists report online in The Journal of Infectious Diseases... (Source: HIV / AIDS News From Medical News Today)

The Association Between a Functional CYP1A1 Polymorphism and Colorectal Neoplasia Risk in Post Menopausal Women

Digestive Diseases and Sciences — Fri, 22 Jan 2010 09:52:55 +0100

Conclusions Carriers of the A allele of the C4887A polymorphism have enhanced estrogen catabolism and lower free estradiol. Our results suggest, however, that inherent estrogen metabolism as determined by C4887A polymorphisms is not associated with CRN risk. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-009-1105-9Authors Dayna S. Early, Washington University in St. Louis Division of Gastroenterology 660 South Euclid Campus Box 8124 St. Louis MO USAFeng Gao, Washington University in St. Louis Division of Biostatistics St. Louis MO USAChristina Y. Ha, Washington University in St. Louis Division of Gastroenterology 660 South Euclid Campus Box 8124 St. Louis MO USAAnne Nagler, Washington University in St. Louis Department of Medicine St. Louis MO ...

COMPASS Directs Children Away From Obesity

RWJF News Digest - Childhood Obesity — Fri, 22 Jan 2010 05:00:00 +0100

Losing weight really is a family affair, especially when it comes to children. Researchers at Washington University St. Louis are studying ways of reducing obesity in kids by enlisting the help of their parents – the grocery-buyers and ultimate decision makers – in losing weight. (Source: RWJF News Digest - Childhood Obesity)

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HIV infection prematurely ages the brain

EurekAlert! - Medicine and Health — Thu, 21 Jan 2010 05:00:00 +0100

(Washington University School of Medicine) HIV infection or the treatments used to control it are prematurely aging the brain, researchers at Washington University School of Medicine in St. Louis and the University of California, San Diego have found. Blood flow in the brains of HIV patients is reduced to levels normally seen in uninfected patients 15 to 20 years older. (Source: EurekAlert! - Medicine and Health)

Siteman Cancer Center, Wash. U. to get $1M a year from Alvin Siteman

bizjournals.com Health Care:Biotechnology headlines — Wed, 20 Jan 2010 21:44:25 +0100

Alvin J. Siteman has pledged to fund an endowment that will provide at least $1 million a year for research on cancer prevention, diagnosis and treatment at his namesake cancer center at Washington University. (Source: bizjournals.com Health Care:Biotechnology headlines)

Providing Contraception for Women Taking Potentially Teratogenic Medications: A Survey of Internal Medicine Physicians’ Knowledge, Attitudes and Barriers

Journal of General Internal Medicine — Tue, 19 Jan 2010 17:29:23 +0100

CONCLUSIONS Primary care physicians commonly encounter reproductive age women taking category D or X medications, but may lack sufficient knowledge and time to counsel about potential teratogens and contraception to prevent fetal exposure to these drugs. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11606-009-1215-2Authors David L. Eisenberg, Washington University in St. Louis School of Medicine Department of Obstetrics & Gynecology, Division of Clinical Research 4533 Clayton Ave St. Louis MO 63110 USACatherine Stika, Northwestern University Feinberg School of Medicine Department of Obstetrics & Gynecology Chicago IL USAAmi Desai, Northwestern University Feinberg School of Medicine Department of Internal Medicine Chicago IL USADavid Baker, Northwest...

Drowsiness, staring and other mental lapses may signal Alzheimer's disease

ScienceDaily Headlines — Tue, 19 Jan 2010 16:00:00 +0100

Staring, sleepiness, other mental lapses

Medicineworld.org: New Article Alert — Tue, 19 Jan 2010 14:04:47 +0100

Cognitive fluctuations, or episodes when train of thought temporarily is lost, are more likely to occur in older persons who are in the process of developing Alzheimer's disease than in their healthy peers, as per researchers at Washington University School of Medicine in St. Louis. Cognitive fluctuations include excessive daytime sleepiness, staring into space and disorganized or illogical thinking........ (Source: Medicineworld.org: New Article Alert)

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Staring, Sleepiness, Other Mental Lapses More Likely In Patients With Alzheimer's

Health News from Medical News Today — Tue, 19 Jan 2010 10:00:00 +0100

Cognitive fluctuations, or episodes when train of thought temporarily is lost, are more likely to occur in older persons who are developing Alzheimer's disease than in their healthy peers, according to scientists at Washington University School of Medicine in St. Louis. Cognitive fluctuations include excessive daytime sleepiness, staring into space and disorganized or illogical thinking. "If you have these lapses, they don't by themselves mean that you have Alzheimer's," says senior author James Galvin, M.D., a Washington University neurologist at Barnes-Jewish Hospital... (Source: Health News from Medical News Today)

Staring, Sleepiness, Other Mental Lapses More Likely In Patients With Alzheimer's

Alzheimer's / Dementia News From Medical News Today — Tue, 19 Jan 2010 10:00:00 +0100

Cognitive fluctuations, or episodes when train of thought temporarily is lost, are more likely to occur in older persons who are developing Alzheimer's disease than in their healthy peers, according to scientists at Washington University School of Medicine in St. Louis. Cognitive fluctuations include excessive daytime sleepiness, staring into space and disorganized or illogical thinking... (Source: Alzheimer's / Dementia News From Medical News Today)

Duodenum - Endoscopic Management of a Windsock Diveticulum

The Digital Atlas of Video Education - Gastroenterology — Tue, 19 Jan 2010 09:01:09 +0100

A 24 year old female was referred for complaints intermittent nausea and vomiting and weight loss. The upper GI barium study demonstrates an enlarged diverticulum in the second portion of the duodenum. A thin radiolucent stripe is seen around the diverticulum which has been described as the halo sign. Upper endoscopy is performed which identifies a large diverticulum which intermittently obstructs the duodenal lumen. The endoscopic appearance is consistent with a windsock diverticulum. This intraluminal diverticulum is thought to result from incomplete recanalization of the duodenum during embryological development and with complete obstruction, symptoms present during childhood. In contrast, when there is a small aperture in the duodenum, patients may initially remain asymptomatic. Howeve...

Effect of cognitive fluctuation on neuropsychological performance in aging and dementia

Neurology — Mon, 18 Jan 2010 21:01:19 +0100

Conclusions: Cognitive fluctuations occur in Alzheimer disease and, when present, significantly affect both clinical rating of dementia severity and neuropsychological performance. Assessment of fluctuations should be considered in the evaluation of patients for cognitive disorders. (Source: Neurology)

Staring, sleepiness, other mental lapses more likely in patients with Alzheimer's

EurekAlert! - Social and Behavioral Science — Mon, 18 Jan 2010 05:00:00 +0100

(Washington University School of Medicine) Cognitive fluctuations, or episodes when train of thought temporarily is lost, are more likely to occur in older persons who are developing Alzheimer's disease than in their healthy peers, according to scientists at Washington University School of Medicine in St. Louis. Cognitive fluctuations include excessive daytime sleepiness, staring into space and disorganized or illogical thinking. (Source: EurekAlert! - Social and Behavioral Science)

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Monitoring the Adequacy of Catch-Up Growth Among Moderately Malnourished Children Receiving Home-Based Therapy Using Mid-Upper Arm Circumference in Southern Malawi

Maternal and Child Health Journal — Fri, 15 Jan 2010 18:01:40 +0100

This study attempts to discern if Mid-upper Arm Circumference (MUAC) measurements collected by community-based health aides have the potential to monitor changes in nutritional status among moderately malnourished Malawian children while undergoing HBT using RUTF. Retrospective analysis was performed using the anthropometric data of 1,904 moderately malnourished children during treatment using RUTF. Changes in MUAC and changes in overall weight at 1 and 2 months of treatment were compared. Various geometric relationships were explored between the measures to find the most direct relationship. Models were developed to investigate anthropometric changes in children undergoing treatment. These data reveal that the correlation between the changes in MUAC and changes in weight over ...

[Perspectives] Lifeline: Eric D Green

LANCET — Fri, 15 Jan 2010 00:00:00 +0100

Eric D Green became the director of the National Human Genome Research Institute at the US National Institutes of Health (NIH) in December, 2009. Previously, he was that institute's Scientific Director. He received an MD and PhD, in 1987, from Washington University School of Medicine in St Louis, Missouri, USA, where he was born and raised. (Source: LANCET)

When pathways intersect: MCSF-R AND ITAMs in myeloid cell functions

Videocast - All Events — Thu, 14 Jan 2010 14:03:00 +0100

Dr Colonna is a Professor of Pathology and Immunology at Washington University School of Medicine in St. Louis. He received his MD in Parma Italy, and trained with Jack Strominger at Harvard. His work has contributed significantly to our understanding of inhibitory receptor signaling in natural killer cells. Dr Colonna has also done seminal work on plasmacytoid dendritic cells, including identifying Siglec-H, and showing that it is a pDC specific receptor that can inhibit IFN secretion via DAP12. He always has new and interesting data to present. The Immunology Interest Group Air date: 1/20/2010 4:15:00 PM (Source: Videocast - All Events)

Sexual Behaviors and Results of Bacterial Sexually Transmitted Infections Testing Among Frail HIV-Infected Individuals

Journal of the International Association of Physicians in AIDS Care (JIAPAC) — Wed, 13 Jan 2010 18:31:41 +0100

Conclusion: In this relatively young population, frailty did not affect reports of recent sexual activity or consistent condom use and no significant difference in STI prevalence was observed. (Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC))

Drug That Modifies Gene Activity Could Help Some Older Leukemia Patients

Lymphoma / Leukemia News From Medical News Today — Wed, 13 Jan 2010 11:00:00 +0100

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Drug That Modifies Gene Activity Could Help Some Older Leukemia Patients

Health News from Medical News Today — Wed, 13 Jan 2010 11:00:00 +0100

Older patients with acute myeloid leukemia (AML) might benefit from a drug that reactivates genes that cancer cells turn off, according to research at Washington University School of Medicine in St. Louis and collaborating institutions. The researchers say the findings support further investigation of the drug, decitabine, as a first-line treatment for these patients, who have limited treatment options. Almost two-thirds of AML patients over age 65 do not receive treatment for the disease because standard therapy can be risky and often is ineffective... (Source: Health News from Medical News Today)

Save the Date! Navigating Collaboration: Strategies for Overcoming Barriers

Midcontinental Region News — Tue, 12 Jan 2010 14:47:14 +0100

Navigating Collaboration: A Crash Course in Connecting with the Community Tune in to the next episode of the webinar series brought to you by the MidContinental Region’s Collaboration Working Group. Over the past year, the members of this working group collaborated to develop an online resource to share with NN/LM MCR members and others on how to develop and maintain collaborative relationships with people and organizations outside your library. Each of the five webinars includes information and resources, plus an open time to allow attendees to share thoughts and experiences in the topic area. The next episode is scheduled for January 26 at 1:00 MT/2:00CT Strategies for Overcoming Barriers will be presented by Melody Kinnamon, Consumer Health Librarian, Johnson County Library, Overl...

Drug that modifies gene activity could help some older leukemia patients

EurekAlert! - Social and Behavioral Science — Tue, 12 Jan 2010 05:00:00 +0100

(Washington University School of Medicine) Older patients with acute myeloid leukemia (AML) might benefit from a drug that reactivates genes that cancer cells turn off, according to research at Washington University School of Medicine in St. Louis and collaborating institutions. The researchers say the findings support further investigation of the drug, decitabine, as a first-line treatment for these patients, who have limited treatment options. (Source: EurekAlert! - Social and Behavioral Science)

Donepezil Treatment and Changes in Hippocampal Structure in Very Mild Alzheimer Disease [Original Contribution]

Archives of Neurology — Mon, 11 Jan 2010 20:52:42 +0100

Conclusions Treatment with donepezil did not alter the progression of hippocampal deformation in subjects with DAT in this study. Small sample size may have contributed to this outcome. (Source: Archives of Neurology)

Ensuring long-term sustainability of existing cohorts remains the highest priority to inform cancer prevention and control

Cancer Causes and Control — Fri, 08 Jan 2010 21:40:27 +0100

Abstract The case for continued follow-up of existing cohorts arises from the key attributes of cohorts that are already meeting the goals proposed by Potter for the creation of a new cohort. These attributes include the basic nature of ongoing cohorts in that they are, by design, hypothesis-driven and must adapt to emerging technologies over time. Importantly, cohort investigators must identify and address gaps in knowledge that will inform public health strategies and clinical practices. Above all, cohorts must capitalize on their unique features to address public health priorities and inform our prevention strategies. Continued follow-up adds substantial return on investment to guide cancer prevention. Content Type Journal ArticleCategory EditorialDOI 10.1007/s10552-0...

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Essentials of Infectious Disease Epidemiology & Essential Readings in Infectious Disease Epidemiology by M. Magnus

Annals of Epidemiology — Fri, 08 Jan 2010 15:48:21 +0100

The occurrence of the H1N1 influenza (swine flu) epidemic of 2009, rather than a long-planned for H5N1 avian influenza epidemic, should disabuse anyone still laboring under the misconception that infectious diseases had once and for all been completely understood, much less conquered in the 20th century (1). Even in the 1960s and 1970s when this view was most prevalent in the United States, it was patently untrue from a global standpoint. This attitude and the resulting lack of shoe-leather epidemiologists working in Africa may have contributed to allowing the HIV/AIDS epidemic to grow for decades unnoticed by the rich nations until it was too late to stop its pandemic spread to rich and poor nations alike. Dr Manya Magnus of George Washington University School of Public Health has produc...

Data On Cervical Cancer Published By Researchers At Washington University

Cancercompass News: Gynecological Cancer — Thu, 07 Jan 2010 00:00:00 +0100

Cervical cancer tumor size determined by F-18- fluorodeoxyglucose-positron emission tomography (FDG-PET) thresholding of the maximum standardized uptake value (SUVMax) has been correlated with the determined tumor size by computed tomography and magnetic resonance imaging. (Source: Cancercompass News: Gynecological Cancer)

Pre-operative assessment enables early diagnosis and recovery of shoulder function in patients with breast cancer

Breast Cancer Research and Treatment — Wed, 06 Jan 2010 18:07:07 +0100

Abstract In order to determine the extent and time course of upper limb impairment and dysfunction in women being treated for breast cancer (BC), and followed prospectively, a novel physical therapy surveillance model post-treatment was used. Subjects included adult women with newly diagnosed, untreated, unilateral, Stage I to III BC, and normal physiological and biomechanical shoulder function. Subjects were excluded if they had a previous history of BC, or prior injury or surgery of the affected upper limb. Measurements included body weight, shoulder ranges of motion (ROM), manual muscle tests, pain levels, upper limb volume, and an upper limb disability questionnaire (ULDQ). Measurements were taken at baseline (pre-surgery), and 1, 3–6, and 12 months post-surgery...

Temporal trends in area socioeconomic disparities in breast-cancer incidence and mortality, 1988–2005

Breast Cancer Research and Treatment — Wed, 06 Jan 2010 18:06:59 +0100

Abstract Since an overarching goal of Healthy People 2010 was to eliminate health disparities, we determined temporal trends in socioeconomic disparities in five breast-cancer indicators (in situ, stage I, lymph-node positive, and locally advanced breast-cancer incidence, and breast-cancer mortality) by county socioeconomic deprivation using 1988–2005 population-based breast-cancer data. Using 1988–2005 data from women aged 40 and older from 200 counties in the Surveillance, Epidemiology, and End Results program, we examined trends in temporal disparities in the five breast-cancer indicators across quartiles of county socioeconomic deprivation. County-level trends were summarized using the estimated annual percentage change. Observed county rates were smoothed using Ba...

Differential regulation of MMP-2 in the gastrohepatic ligament of the gastroesophageal junction

Surgical Endoscopy — Wed, 06 Jan 2010 18:05:09 +0100

Conclusions Gelatinase-A (MMP-2) is present in the GHL and plasma of control patients. The GHL may provide the primary GE junction supporting ligament to compare tissue from patients with type I (sliding) and type III (paraesophageal) hiatal hernias to examine the role of altered collagen metabolism in hiatal hernia formation. Content Type Journal ArticleDOI 10.1007/s00464-009-0811-xAuthors Lora Melman, Washington University School of Medicine Department of Surgery, Section of Minimally Invasive Surgery 660 South Euclid Avenue Campus Box #8109 St. Louis MO 63110 USAPhillip R. Chisholm, Washington University School of Medicine Department of Surgery, Section of Minimally Invasive Surgery 660 South Euclid Avenue Campus Box #8109 St. Louis MO 63110 USAJohn A. Curci, Washi...

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Transanal single-port low anterior resection in a cadaver model

Surgical Endoscopy — Wed, 06 Jan 2010 18:05:06 +0100

Conclusions Transanal single-port low anterior resection using TEM and laparoscopic techniques is feasible and can maintain the principles of an oncologic resection. Content Type Journal ArticleCategory VideoDOI 10.1007/s00464-009-0838-zAuthors Alyssa D. Fajardo, Washington University in St. Louis School of Medicine Department of Surgery, Section of Colon and Rectal Surgery 660 S. Euclid Avenue Campus Box 8109 Saint Louis MO 63110 USASteven R. Hunt, Washington University in St. Louis School of Medicine Department of Surgery, Section of Colon and Rectal Surgery 660 S. Euclid Avenue Campus Box 8109 Saint Louis MO 63110 USAJames W. Fleshman, Washington University in St. Louis School of Medicine Department of Surgery, Section of Colon and Rectal Surgery 660 S. Euclid Avenu...

The Pathogenic Implication of Abnormal Interaction Between Apolipoprotein E Isoforms, Amyloid-beta Peptides, and Sulfatides in Alzheimer’s Disease

Molecular Neurobiology — Wed, 06 Jan 2010 06:55:50 +0100

Abstract Alzheimer’s disease (AD) is the most common cause of dementia in the aging population. Prior work has shown that the ε4 allele of apolipoprotein E (apoE4) is a major risk factor for “sporadic” AD, which accounts for >99% of AD cases without a defined underlying mechanism. Recently, we have demonstrated that sulfatides are substantially and specifically depleted at the very early stage of AD. To identify the mechanism(s) of sulfatide loss concurrent with AD onset, we have found that: (1) sulfatides are specifically associated with apoE-associated particles in cerebrospinal fluid (CSF); (2) apoE modulates cellular sulfatide levels; and (3) the modulation of sulfatide content is apoE isoform dependent. These findings not only lead to identification of the p...

Another look at Emergency Department HIV screening in practice: no need to revise expectations

AIDS Research and Therapy — Tue, 05 Jan 2010 00:00:00 +0100

Conclusion: Review of our data conflict with findings from the USHER study surrounding false positive OraQuick HIV screening. Our data suggest that rapid HIV screening protocols implemented in EDs outside of the clinical trial paradigm perform effectively without an excess of false positive results. Compared with other screening tests, HIV rapid screening should remain an essential component of ED practice. (Source: AIDS Research and Therapy)

Another look at Emergency Department HIV screening in practice: no need to revise expectations.

AIDS Research and Therapy — Tue, 05 Jan 2010 00:00:00 +0100

CONCLUSION: Review of our data conflict with findings from the USHER study surrounding false positive OraQuick HIV screening. Our data suggest that rapid HIV screening protocols implemented in EDs outside of the clinical trial paradigm perform effectively without an excess of false positive results. Compared with other screening tests, HIV rapid screening should remain an essential component of ED practice. PMID: 20051116 [PubMed - as supplied by publisher] (Source: AIDS Research and Therapy)