MedWorm: Aspergillus

Whole genome evaluation of horizontal transfers in the pathogenic fungus Aspergillus fumigatus

The Aspergillus Website - articles — Fri, 19 Mar 2010 00:00:00 +0100

Mallet LV, Becq J, Deschavanne P (Source: The Aspergillus Website - articles)

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A case of aspergillus endophthalmitis in an immuncompetent woman: intra-ocular penetration of oral voriconazole: a case report

The Aspergillus Website - articles — Thu, 18 Mar 2010 00:00:00 +0100

Logan S, Rajan M, Graham E, Johnson E, Klein J (Source: The Aspergillus Website - articles)

Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma

Clinical and Molecular Allergy — Thu, 18 Mar 2010 00:00:00 +0100

We examined HLA-DR and HLA-DQ frequencies in Alternaria-sensitive asthmatic by HLA typing. To determine ratios of Th1/Th2 Alternaria-specific T-cells, cultures were stimulated in media alone, Alternaria alternata extract and Alt a1. Sensitivity to IL-4 stimulation was measured by up-regulation of CD23 on B cells. Results: Children with Alternaria-sensitive moderate-severe asthma trended to have increased sensitivities to Cladosporium (46% versus 35%), to Aspergillus (43% versus 28%), and significantly increased sensitivities to trees (78% versus 57%) and to weeds (68% versus 48%). The IL-4RA ile75val polymorphism was significantly increased in Alternaria-sensitive moderate-severe asthmatics, 83% (0.627 allele frequency) compared to Alternaria-sensitive mild asthmatics, 57% (0.388 allele fr...

Prospective Surveillance for Invasive Fungal Infections in Hematopoietic Stem Cell Transplant Recipients, 2001-2006: Overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database

The Aspergillus Website - articles — Thu, 18 Mar 2010 00:00:00 +0100

Kontoyiannis DP, Marr KA, Park BJ, Alexander BD, Anaissie EJ, Walsh TJ, Ito J, Andes DR, Baddley JW, Brown JM, Brumble LM, Freifeld AG, Hadley S, Herwaldt LA, Kauffman CA, Knapp K, Lyon GM, Morrison VA, Papanicolaou G, Patterson TF, Perl TM, Schuster MG, Walker R, Wannemuehler KA, Wingard JR, Chiller TM, Pappas PG (Source: The Aspergillus Website - articles)

Invasive Fungal Infections among Organ Transplant Recipients: Results of the Transplant-Associated Infection Surveillance Network (TRANSNET)

The Aspergillus Website - articles — Thu, 18 Mar 2010 00:00:00 +0100

Pappas PG, Alexander BD, Andes DR, Hadley S, Kauffman CA, Freifeld A, Anaissie EJ, Brumble LM, Herwaldt L, Ito J, Kontoyiannis DP, Lyon GM, Marr KA, Morrison VA, Park BJ, Patterson TF, Perl TM, Oster RA, Schuster MG, Walker R, Walsh TJ, Wannemuehler KA, Chiller TM (Source: The Aspergillus Website - articles)

Differences in spontaneous mutation frequencies as a function of environmental stress in soil fungi at "Evolution Canyon," Israel

The Aspergillus Website - articles — Thu, 18 Mar 2010 00:00:00 +0100

Lamb BC, Mandaokar S, Bahsoun B, Grishkan I, Nevo E (Source: The Aspergillus Website - articles)

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How fungi have shaped our understanding of mammalian immunology

The Aspergillus Website - articles — Thu, 18 Mar 2010 00:00:00 +0100

Brown GD (Source: The Aspergillus Website - articles)

Propionic acid production by cofermentation of Lactobacillus buchneri and Lactobacillus diolivorans in sourdough.

Food Microbiology — Wed, 17 Mar 2010 17:44:32 +0100

In conclusion, cofermentation with L. buchneri and L. diolivorans represents a process to increase antifungal capacities of bread. PMID: 20227604 [PubMed - as supplied by publisher] (Source: Food Microbiology)

Healthy human T-Cell Responses to Aspergillus fumigatus antigens

The Aspergillus Website - articles — Wed, 17 Mar 2010 00:00:00 +0100

Chaudhary N, Staab JF, Marr KA (Source: The Aspergillus Website - articles)

Quantitation of azoles and echinocandins in the compartments of peripheral blood by liquid chromatography tandem mass spectrometry

The Aspergillus Website - articles — Wed, 17 Mar 2010 00:00:00 +0100

Farowski F, Cornely OA, Vehreschild JJ, Hartmann P, Bauer T, Steinbach A, Rüping MJ, Müller C (Source: The Aspergillus Website - articles)

Granulocyte transfusions in severe aplastic anemia: an eleven-year experience

The Aspergillus Website - articles — Wed, 17 Mar 2010 00:00:00 +0100

Quillen K, Wong E, Scheinberg P, Young NS, Walsh TJ, Wu CO, Leitman SF (Source: The Aspergillus Website - articles)

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Is canine fossa access necessary for successful maxillary fungus ball treatment?

The Aspergillus Website - articles — Wed, 17 Mar 2010 00:00:00 +0100

Pagella F, Matti E, Giourgos G, Colombo A, De Bernardi F, Castelnuovo P (Source: The Aspergillus Website - articles)

Regulation of Septum Formation by the Bud3-Rho4 GTPase Module in Aspergillus nidulans

The Aspergillus Website - articles — Wed, 17 Mar 2010 00:00:00 +0100

Si H, Justa-Schuch D, Seiler S, Harris SD (Source: The Aspergillus Website - articles)

Further screening of Aspergillus species for occurrence of lectins and their partial characterization

The Aspergillus Website - articles — Wed, 17 Mar 2010 00:00:00 +0100

Singh RS, Bhari R, Rai J (Source: The Aspergillus Website - articles)

Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans

The Aspergillus Website - articles — Wed, 17 Mar 2010 00:00:00 +0100

Sanchez JF, Chiang YM, Szewczyk E, Davidson AD, Ahuja M, Elizabeth Oakley C, Woo Bok J, Keller N, Oakley BR, Wang CC (Source: The Aspergillus Website - articles)

Invasive filamentous fungal infections associated with renal transplant tourism

The Aspergillus Website - articles — Wed, 17 Mar 2010 00:00:00 +0100

Shoham S, Hinestrosa F, Moore J Jr, O'Donnell S, Ruiz M, Light J (Source: The Aspergillus Website - articles)

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Allergic Bronchopulmonary Aspergillosis in a child

The Aspergillus Website - articles — Tue, 16 Mar 2010 00:00:00 +0100

Raymond G. Slavin, M.D., T. Scott Laird, M.D., and James D. Cherry, M.D. (Source: The Aspergillus Website - articles)

Melanoma Associated With Long-term Voriconazole Therapy: A New Manifestation of Chronic Photosensitivity [Observation]

Archives of Dermatology — Mon, 15 Mar 2010 19:50:58 +0100

Conclusions We recommend surveillance for skin cancer formation in all patients who require long-term voriconazole treatment, particularly those who manifest signs or symptoms of photosensitivity or chronic photodamage. Further study of the mechanism underlying voriconazole photosensitivity and oncogenesis is warranted. Published online January 18, 2010 (doi:10.1001/archdermatol.2009.362). (Source: Archives of Dermatology)

Synthesis and Antifungal Activity of 1-Aryl-3-phenethylamino-1-propanone Hydrochlorides and 3-Aroyl-4-aryl-1-phenethyl-4-piperidinols

Archiv der Pharmazie — Mon, 15 Mar 2010 00:00:00 +0100

Mono-Mannich bases, 1-aryl-3-phenethylamino-1-propanone hydrochlorides, 1a, 2a, 3a, 4a, 5a, 6a, 7a, 8a, 9a, and semi-cyclic mono-Mannich bases, 3-aroyl-4-aryl-1-phenethyl-4-piperidinols, 1b, 2b, 3b, 4b, 5b, 6b, 7b, 8b, 9b, were synthesized by a non-classical Mannich reaction. The aryl part was: C6H5 for 1a, 1b; 4-CH3C6H4 for 2a, 2b; 4-CH3OC6H4 for 3a, 3b; 4-ClC6H4 for 4a, 4b; 4-FC6H4 for 5a, 5b; 4-BrC6H4 for 6a, 6b; 2,4-(Cl)2C6H3 for 7a, 7b; 4-NO2C6H4 for 8a, 8b; and C4H3S(2-yl) i. e., 2-thienyl for 9a, 9b. Piperidinol compounds 2b, 3b, 4b, 5b, 7b, 8b, and 9b are reported here for the first time. The synthesized compounds were tested against seven types of plant pathogenic fungi and three types of human pathogenic fungi using the agar dilution assay. Itraconazole was tested against Candida...

Overall survival and fungal infection-related mortality in patients with invasive fungal infection and neutropenia after myelosuppressive chemotherapy in a tertiary care centre from 1995 to 2006

Journal of Antimicrobial Chemotherapy — Fri, 12 Mar 2010 16:27:28 +0100

Conclusions Compared with 1995–2001, IFI-related mortality decreased and OS in patients with IFI increased significantly in recent years. Improved OS was associated with controlled haematological disease, certainty of IFI diagnosis (possible), younger age, time period 2002–06 and the use of novel antifungals. (Source: Journal of Antimicrobial Chemotherapy)

Chapter 8 - Fungal infections in immunocompromised patients

Jornal Brasileiro de Pneumologia — Fri, 12 Mar 2010 15:34:44 +0100

As complicações pulmonares se constituem na maior causa de morbidade e mortalidade no hospedeiro imunocomprometido, devido à deficiência nos mecanismos básicos de defesa. Independente da causa da imunodepressão, infecções bacterianas, virais e fúngicas são as mais frequentes. Entre as infecções fúngicas, a aspergilose é a mais comum (incidência de 1-9% e mortalidade de 55-92%) nos diferentes tipos de transplantados. Embora a forma pneumônica seja a mais frequente, lesões do sistema nervoso central e sinusite não são raras. O sinal do halo em TC de tórax representa uma área de baixa atenuação em volta do nódulo, revelando edema ou hemorragia. O padrão ouro para o diagnóstico é a identificação do fungo por cultura de escarro, amostras de LBA ou biópsia. Na falta...

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Prognostic Features of Galactomannan Antigenemia in Galactomannan-Positive Invasive Aspergillosis

The Aspergillus Website - articles — Fri, 12 Mar 2010 00:00:00 +0100

Koo S, Bryar JM, Baden LR, Marty FM (Source: The Aspergillus Website - articles)

Differences in voriconazole trough plasma concentrations per oral dosages between children younger and older than 3 years of age

The Aspergillus Website - articles — Fri, 12 Mar 2010 00:00:00 +0100

Shima H, Miharu M, Osumi T, Takahashi T, Shimada H (Source: The Aspergillus Website - articles)

Evaluation of the Etest method for susceptibility testing of Aspergillus spp. and Fusarium spp. to three echinocandins

The Aspergillus Website - articles — Fri, 12 Mar 2010 00:00:00 +0100

Martos AI, Romero A, González MT, González A, Serrano C, Castro C, Pemán J, Cantón E, Martín-Mazuelos E (Source: The Aspergillus Website - articles)

Aspergillus and the paediatric lung

The Aspergillus Website - articles — Fri, 12 Mar 2010 00:00:00 +0100

Hatziagorou E, Walsh TJ, Tsanakas JN, Roilides E (Source: The Aspergillus Website - articles)

Performance of the galactomannan antigen detection test in the diagnosis of invasive aspergillosis in children with cancer or undergoing haemopoietic stem cell transplantation

The Aspergillus Website - articles — Fri, 12 Mar 2010 00:00:00 +0100

Castagnola E, Furfaro E, Caviglia I, Licciardello M, Faraci M, Fioredda F, Tomà P, Bandettini R, Machetti M, Viscoli C (Source: The Aspergillus Website - articles)

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The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans

The Aspergillus Website - articles — Fri, 12 Mar 2010 00:00:00 +0100

Han KH, Chun YH, de Castro Pimentel Figueiredo B, Soriani FM, Savoldi M, Almeida A, Rodrigues F, Cairns CT, Bignell E, Tobal JM, Goldman MH, Kim JH, Bahn YS, Goldman GH, da Silva Ferreira ME (Source: The Aspergillus Website - articles)

Organising pneumonia mimicking invasive fungal disease in patients with leukaemia

The Aspergillus Website - articles — Fri, 12 Mar 2010 00:00:00 +0100

Forghieri F, Potenza L, Morselli M, Maccaferri M, Pedrazzi L, Barozzi P, Vallerini D, Riva G, Zanetti E, Quadrelli C, Rossi G, Rivasi F, Messino M, Rumpianesi F, Grottola A, Venturelli C, Pecorari M, Codeluppi M, Torelli G, Luppi M (Source: The Aspergillus Website - articles)

Asperfuranone from Aspergillus nidulans Inhibits Proliferation of Human Non-Small Cell Lung Cancer A549 Cells via Blocking Cell Cycle Progression and Inducing Apoptosis

The Aspergillus Website - articles — Fri, 12 Mar 2010 00:00:00 +0100

Wang CC, Chiang YM, Praseuth MB, Kuo PL, Liang HL, Hsu YL (Source: The Aspergillus Website - articles)

A Cutaneous Model of Invasive Aspergillosis

The Aspergillus Website - articles — Fri, 12 Mar 2010 00:00:00 +0100

Ben-Ami R, Lewis RE, Leventakos K, Latgé JP, Kontoyiannis DP (Source: The Aspergillus Website - articles)

Whole genome evaluation of horizontal transfers in the pathogenic fungus Aspergillus fumigatus

BMC Genomics - Latest articles — Fri, 12 Mar 2010 00:00:00 +0100

Conclusions: In conclusion, we demonstrated that HTs are not negligible in eukaryote genomes, bearing in mind that in our stringent conditions this amount is a floor value, though of a lesser extent than in prokaryote genomes. The biological mechanisms underlying those transfers remain to be elucidated as well as the biological functions of the transferred genes. (Source: BMC Genomics - Latest articles)

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Invasive Fungal Infections among Organ Transplant Recipients: Results of the Transplant‐Associated Infection Surveillance Network (TRANSNET)

Clinical Infectious Diseases Latest Issue — Thu, 11 Mar 2010 08:04:29 +0100

Conclusions. We detected a slight increase in IFIs during the surveillance period. These data provide important insights into the timing and incidence of IFIs among organ transplant recipients, which can help to focus effective prevention and treatment strategies. (Source: Clinical Infectious Diseases Latest Issue)

Aspergillosis - clinical aspects

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Greenberger PA (Source: The Aspergillus Website - articles)

Stage V (fibrotic) allergic bronchopulmonary aspergillosis. A review of 17 cases followed from diagnosis

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Lee TM, Greenberger PA, Patterson R, Roberts M, Liotta JL (Source: The Aspergillus Website - articles)

Allergic bronchopulmonary aspergillosis (radiological aspects)

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Menon MP, Das AK (Source: The Aspergillus Website - articles)

Allergic bronchopulmonary aspergillosis in the asthma clinic. A prospective evaluation of CT in the diagnostic algorithm

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Eaton T, Garrett J, Milne D, Frankel A, Wells AU (Source: The Aspergillus Website - articles)

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Cyclophosphamide reduces dectin-1 expression in the lungs of naive and Aspergillus fumigatus-infected mice

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Yang J, Lu Q, Liu W, Wan Z, Wang X, Li R (Source: The Aspergillus Website - articles)

Mucoid impaction of the bronchi

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Urschel HC Jr, Paulson DL, Shaw RR (Source: The Aspergillus Website - articles)

Biochemical and antigenic characterization of a new dipeptidyl-peptidase isolated from Aspergillus fumigatus

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Beauvais A, Monod M, Debeaupuis JP, Diaquin M, Kobayashi H, Latgé JP (Source: The Aspergillus Website - articles)

Characterization of the Aspergillus nidulans aspnd1 gene demonstrates that the ASPND1 antigen, which it encodes, and several Aspergillus fumigatus immunodominant antigens belong to the same family

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Calera JA, Ovejero MC, López-Medrano R, Segurado M, Puente P, Leal F (Source: The Aspergillus Website - articles)

Interstrain variability in the virulence of Aspergillus fumigatus and Aspergillus terreus in a Toll-deficient Drosophila fly model of invasive aspergillosis

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Ben-Ami R, Lamaris GA, Lewis RE, Kontoyiannis DP (Source: The Aspergillus Website - articles)

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Clinical significance of hyperattenuating mucoid impaction in allergic bronchopulmonary aspergillosis: an analysis of 155 patients

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Agarwal R, Gupta D, Aggarwal AN, Saxena AK, Chakrabarti A, Jindal SK (Source: The Aspergillus Website - articles)

Allergic bronchopulmonary aspergillosis

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Greenberger PA (Source: The Aspergillus Website - articles)

Allergic bronchopulmonary aspergillosis: the spectrum of computed tomography appearances

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Panchal N, Bhagat R, Pant C, Shah A (Source: The Aspergillus Website - articles)

Galactomannan testing of bronchoalveolar lavage fluid is useful for diagnosis of invasive pulmonary aspergillosis in hematology patients

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Hsu LY, Ding Y, Phua J, Koh LP, Chan DS, Khoo KL, Tambyah PA (Source: The Aspergillus Website - articles)

Genetic Characterization of the Monodictyphenone Gene Cluster in Aspergillus nidulans

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Chiang YM, Szewczyk E, Davidson AD, Entwistle R, Keller NP, Wang CC, Oakley BR (Source: The Aspergillus Website - articles)

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Isolation and identification of FR198248, a hydroxylated 1,3-dihydroisobenzofuran, from Aspergillus flavipes as an inhibitor of peptide deformylase

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Kwon YJ, Zheng CJ, Kim WG (Source: The Aspergillus Website - articles)

The concerted action of bZip and cMyb transcription factors FlbB and FlbD induces brlA expression and asexual development in Aspergillus nidulans

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Garzia A, Etxebeste O, Herrero-García E, Ugalde U, Espeso EA (Source: The Aspergillus Website - articles)

Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Reyes-Dominguez Y, Bok JW, Berger H, Shwab EK, Basheer A, Gallmetzer A, Scazzocchio C, Keller N, Strauss J (Source: The Aspergillus Website - articles)

AtfA bZIP-type transcription factor regulates oxidative and osmotic stress responses in Aspergillus nidulans

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Balázs A, Pócsi I, Hamari Z, Leiter E, Emri T, Miskei M, Oláh J, Tóth V, Hegedus N, Prade RA, Molnár M, Pócsi I (Source: The Aspergillus Website - articles)

Detection of Aspergillus fumigatus in A Rat Model of Invasive Pulmonary Aspergillosis by Real-time Nucleic Acid Sequence-Based Amplification (NASBA)

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Zhao Y, Park S, Warn P, Shrief R, Harrison E, Perlin DS (Source: The Aspergillus Website - articles)

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The impact of portable high-efficiency particulate air filters on the incidence of invasive aspergillosis in a large acute tertiary-care hospital

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Abdul Salam ZH, Karlin RB, Ling ML, Yang KS (Source: The Aspergillus Website - articles)

Transcriptional Regulation of Chitin Synthases by Calcineurin Controls Paradoxical Growth of Aspergillus fumigatus in Response to Caspofungin

The Aspergillus Website - articles — Thu, 11 Mar 2010 00:00:00 +0100

Fortwendel JR, Juvvadi PR, Perfect BZ, Rogg LE, Perfect JR, Steinbach WJ (Source: The Aspergillus Website - articles)

DNA cleavage and antimicrobial investigation of Co(II), Ni(II), and Cu(II) complexes with triazole Schiff bases: synthesis and spectral characterization

Medicinal Chemistry Research — Wed, 10 Mar 2010 12:53:56 +0100

Abstract The Co(II), Ni(II), and Cu(II) complexes with Schiff bases derived from 3-substituted-4-amino-5-mercapto-1,2,4-triazole and fluvastatin have been synthesized. Schiff bases exhibited thiol–thione tautomerism and coordinated to metal ion through azomethine nitrogen and thiolate sulphur atoms. Square planar geometry for all the metal complexes of the type ML2 has been proposed in the light of analytical, spectral (IR, UV–Vis., ESR, and FAB-mass), magnetic, and thermal studies. The antimicrobial studies of Schiff bases and their metal complexes against various antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus subtilis) and antifungal (Aspergillus niger, and Pencillium Chrysogenum) species by Minimum Inhibitory Concentration m...

The antifungal protein AFP from Aspergillus giganteus prevents secondary growth of different Fusarium species on barley.

Applied Microbiology and Biotechnology — Wed, 10 Mar 2010 00:00:00 +0100

Authors: Barakat H, Spielvogel A, Hassan M, El-Desouky A, El-Mansy H, Rath F, Meyer V, Stahl U Secondary growth is a common post-harvest problem when pre-infected crops are attacked by filamentous fungi during storage or processing. Several antifungal approaches are thus pursued based on chemical, physical, or bio-control treatments; however, many of these methods are inefficient, affect product quality, or cause severe side effects on the environment. A protein that can potentially overcome these limitations is the antifungal protein AFP, an abundantly secreted peptide of the filamentous fungus Aspergillus giganteus. This protein specifically and at low concentrations disturbs the integrity of fungal cell walls and plasma membranes but does not interfere with the viability of other pr...

Pacing lead endocarditis due to

Indian Journal of Medical Microbiology — Tue, 09 Mar 2010 17:15:51 +0100

We present here a case of Aspergillus fumigatus tricuspid valve endocarditis associated with permanent pacemaker leads. Tricuspid valve vegetectomy was done and the pacing leads were also removed. Culture from the excised vegetation grew Aspergillus fumigatus. The patient was started on IV Amphotericin B for eight weeks. The patient was subsequently followed up in the out-patient clinic, and remains afebrile after one year, with no evidence of any vegetation. (Source: Indian Journal of Medical Microbiology)

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lip2, a novel lipase gene cloned from Aspergillus niger exhibits enzymatic characteristics distinct from its previously identified family member.

Biotechnology Letters — Mon, 08 Mar 2010 00:00:00 +0100

Authors: Yang J, Sun J, Yan Y We have cloned a novel lipase gene, lip2, from Aspergillus niger and expressed it in Escherichia coli. Upon purification of the recombinant Lip2 protein, its properties were characterized. In comparison with a previously identified lipase Lip1, both enzymes are acid lipases (optimal pH <6.5), Ca(2+)-dependent and PMSF-sensitive, but have different molecular weights (35 and 43 kDa), optimal substrate spectra (C10 and C8), optimal reaction temperatures (45 and 50 degrees C) and thermal stability. Circular dichroism spectroscopy revealed that Lip2 contains a typical Ca(2+)-active site. This first report on the cloning of the Lip2 gene and its enzymatic characteristics may greatly facilitate its potential industrial application. PMID: 20213520 [PubMed -...

Aspergillus: Molecular Biology and Genomics. By Masayuki Machida and Katsuya Gomi (Eds.).

Biotechnology Journal — Mon, 08 Mar 2010 00:00:00 +0100

Authors: Bignell E no abstract. PMID: 20213644 [PubMed - as supplied by publisher] (Source: Biotechnology Journal)

Citric acid production by Koji fermentation using banana peel as a novel substrate.

Bioresource Technology — Mon, 08 Mar 2010 00:00:00 +0100

Authors: Karthikeyan A, Sivakumar N The growing demand for citric acid and the current need for alternative sources have encouraged biotechnologists to search for novel and economical substrates. Koji fermentation was conducted using the peels of banana (Musa acuminata) as an inexpensive substrate for the production of citric acid using Aspergillus niger. Various crucial parameters that affect citric acid production such as moisture content, temperature, pH, inoculum level and incubation time were quantified. Moisture (70%), 28 degrees C temperature, an initial pH 3, 10(8) spores/ml as inoculum and 72h incubation was found to be suitable for maximum citric acid production by A. niger using banana peel as a substrate. PMID: 20219361 [PubMed - as supplied by publisher] (Source: Biore...

Mitotic crossing-over induced by two commercial herbicides in diploid strains of the fungus Aspergillus nidulans.

Genetics and Molecular Research — Sat, 06 Mar 2010 01:08:03 +0100

We examined mitotic crossing-over induced by two commercial herbicides (diuron and trifluralin) in diploid strains of Aspergillus nidulans based on the homozygotization index. Low doses (2.5 mug/mL) of diuron were sufficient to increase the mean homozygotization index in 2.1 and 11.3 times for UT448//UT196 and Dp II-I//UT196, respectively, whereas the same dose of trifluralin increased this mean only 1.2 (UT448//UT196) and 3.5 (Dp II-I//UT196) times, respectively. The lower homozygotization index value found for trifluralin could be due to its interference with mitotic crossing-over in eukaryotic cells. We concluded that the diploid Dp II-I//UT196 of A. nidulans is more sensitive to organic compounds than UT448//UT196; these compounds cause recombinational events at a greater frequency in ...

Fungal Growth Inhibition of Regenerated Cellulose Nanofibrous Membranes Containing Quillaja Saponin.

Archives of Environmental Contamination and Toxicology — Sat, 06 Mar 2010 00:00:00 +0100

Authors: Dixit V, Tewari J, Obendorf SK Antifungal properties were introduced in nonwoven regenerated cellulose (RC) nanofibrous membrane using Quillaja saponin. To generate cellulose membranes, deacetylation of electrospun cellulose acetate (CA) nanofibrous membranes was performed using 0.05 M NaOH and ethanol for membranes both loaded and unloaded with Quillaja saponin. Chemical and physical properties of nonwoven CA and RC nanofibrous membrane were characterized using scanning electron microscopy, attenuated total reflectance-Fourier transform infrared spectroscopy, differential scanning calorimetry, and tensile properties. Our results showed that saponin doping did not affect the morphology of the resulting fibers and that the membrane structure was maintained during deacetylation....

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Synthesis, in-vitro Antimicrobial and Cytotoxic Studies of Novel Azetidinone Derivatives

Archiv der Pharmazie — Fri, 05 Mar 2010 00:00:00 +0100

Developing novel antimicrobial drugs is increasingly important in the modern pharmaceutical industry. A series of novel 3-chloro-4-[4-(2-oxo-2H-chromen-4-ylmethoxy)phenyl]-1-phenylazetidin-2-ones 5a-o have been synthesized from 4-bromomethylcoumarins 1a-e and 4-aryliminomethyl-phenols 3a-c. These compounds were screened for their in-vitro antibacterial activity against two Gram-positive (Staphylococcus aureus and Vancomycin resistant enteroccoccus) and two Gram-negative (Escherichia coli and Shigella dysentery) bacterial strains and antifungal activity against Aspergillus fumigatus, Candida albicans, and Penicillium. Results revealed that compounds 5c, 5f, 5h, 5j, and 5m showed excellent activity against a panel of microorganisms. The brine-shrimp bioassay was also carried out to study the...

Chapter 8: Fungal infections in immunocompromised patients

Jornal Brasileiro de Pneumologia — Thu, 04 Mar 2010 16:48:33 +0100

Enterococcus raffinosus sinusitis post-Aspergillus flavus paranasal infection, in a patient with myelodysplastic syndrome: report of a case and concise review of pertinent literature

Journal of Clinical Pathology — Thu, 04 Mar 2010 15:42:50 +0100

A case of Enterococcus raffinosus nosocomial sinusitis which appeared to complicate a previous Aspergillus flavus paranasal infection is presented. This uncommon enterococcal species is rarely responsible for human diseases, and has never previously been associated with sinusitis. (Source: Journal of Clinical Pathology)

The radiological appearances in allergic broncho-pulmonary aspergillosis

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

McCarthy DS, Simon G, Hargreave FE (Source: The Aspergillus Website - articles)

Murine models of airway fungal exposure and allergic sensitization

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Templeton SP, Buskirk AD, Green BJ, Beezhold DH, Schmechel D (Source: The Aspergillus Website - articles)

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Allergic broncho-pulmonary aspergillosis: the radiological appearance during long-term follow-up

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Phelan MS, Kerr IH (Source: The Aspergillus Website - articles)

Comparative analysis of fungal protein kinases and associated domains

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Kosti I, Mandel-Gutfreund Y, Glaser F, Horwitz BA (Source: The Aspergillus Website - articles)

Overall survival and fungal infection-related mortality in patients with invasive fungal infection and neutropenia after myelosuppressive chemotherapy in a tertiary care centre from 1995 to 2006

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Hahn-Ast C, Glasmacher A, Mückter S, Schmitz A, Kraemer A, Marklein G, Brossart P, von Lilienfeld-Toal (Source: The Aspergillus Website - articles)

Epidemics of mold poisoning past and present

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Meggs WJ (Source: The Aspergillus Website - articles)

The Transposon impala Is Activated by Low Temperatures: Use of a Controlled Transposition System To Identify Genes Critical for Viability of Aspergillus fumigatus

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Carr PD, Tuckwell D, Hey PM, Simon L, d'Enfert C, Birch M, Oliver JD, Bromley MJ (Source: The Aspergillus Website - articles)

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Impact of mold infections in explanted lungs on outcomes of lung transplantation

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Vadnerkar A, Clancy CJ, Celik U, Yousem SA, Mitsani D, Toyoda Y, Nguyen ML, Kwak EJ, Pilewski J, Silveira FP, Crespo M, Nguyen MH (Source: The Aspergillus Website - articles)

Beta-glucan-CRM197 conjugates as candidates antifungal vaccines

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Bromuro C, Romano M, Chiani P, Berti F, Tontini M, Proietti D, Mori E, Torosantucci A, Costantino P, Rappuoli R, Cassone A (Source: The Aspergillus Website - articles)

In vitro characterization and pharmacokinetics in mice following pulmonary delivery of itraconazole as cyclodextrin solubilized solution

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Yang W, Chow KT, Lang B, Wiederhold NP, Johnston KP, Williams RO 3rd (Source: The Aspergillus Website - articles)

Epidemiology of invasive mycoses in North America

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Pfaller MA, Diekema DJ (Source: The Aspergillus Website - articles)

Pharmacokinetics of Liposomal Amphotericin B in Pleural Fluid

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Moriyama B, Torabi-Parizi P, Pratt AK, Henning SA, Pennick G, Shea YR, Chowdhuri SR, Rinaldi MG, Barrett AJ, Walsh TJ (Source: The Aspergillus Website - articles)

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Epidemiology of paediatric invasive fungal infections and a case-control study of risk factors in acute leukaemia or post stem cell transplant

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Hale KA, Shaw PJ, Dalla-Pozza L, Macintyre CR, Isaacs D, Sorrell TC (Source: The Aspergillus Website - articles)

The Aspergillus fumigatus P-Type Golgi Apparatus Ca2+/Mn2+ ATPase PmrA Is Involved in Cation Homeostasis and Cell Wall Integrity but Is Not Essential for Pathogenesis

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Pinchai N, Juvvadi PR, Fortwendel JR, Perfect BZ, Rogg LE, Asfaw YG, Steinbach WJ (Source: The Aspergillus Website - articles)

Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Bien CM, Espenshade PJ (Source: The Aspergillus Website - articles)

Rapid Diagnosis of Azole-Resistant Aspergillosis by polymerase chain reaction directly on tissue specimens

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

van der Linden JW, Snelders E, Arends JP, Daenen SM, Melchers WJ, Verweij PE (Source: The Aspergillus Website - articles)

Molecular aspects of azoles-induced teratogenesis

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Marotta F, Tiboni GM (Source: The Aspergillus Website - articles)

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In situ detection of aspergillus 18s ribosomal RNA Sequences using a terminally biotinylated locked nucleic acid (LNA) probe

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Montone KT, Feldman MD (Source: The Aspergillus Website - articles)

Airway Epithelial Indoleamine 2,3-Dioxygenase Inhibits CD4+ T Cells During Aspergillus fumigatus Antigen Exposure

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Paveglio SA, Allard J, Foster Hodgkins SR, Ather J, Bevelander M, Mayette Campbell J, Whittaker Leclair LA, McCarthy SM, van der Vliet A, Suratt BT, Boyson JE, Uematsu S, Akira S, Poynter ME (Source: The Aspergillus Website - articles)

Epidemiology and outcome of invasive fungal infections in solid organ transplant recipients

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Neofytos D, Fishman JA, Horn D, Anaissie E, Chang CH, Olyaei A, Pfaller M, Steinbach WJ, Webster KM, Marr KA (Source: The Aspergillus Website - articles)

Molecular strategy for identification in Aspergillus section Flavi

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Godet M, Munaut F (Source: The Aspergillus Website - articles)

Significant stimulation of o-phthalic acid in biosynthesis of aspergiolide A by a marine fungus Aspergillus glaucus

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Sun X, Zhou X, Cai M, Zhou J, Zhang Y (Source: The Aspergillus Website - articles)

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Aspergillus fumigatus infection of a biloma

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Ioannidis JP, Snydman DR, Rohrer RJ, Freeman RB, Haug CE (Source: The Aspergillus Website - articles)

Aspergillosis in the middle ear of a harbour porpoise (Phocoena phocoena): a case report

Mycoses — Thu, 04 Mar 2010 00:00:00 +0100

Hearing is one of the major senses in whales and dolphins (cetaceans). This is the first report of severe mycotic otitis media in a cetacean, a juvenile female harbour porpoise (Phocoena phocoena) from British waters that stranded alive. Gross examinations were followed by histological and microbiological investigations of the auditory apparatus. Both tympanic cavities and periotic sinuses displayed copious greenish-yellow purulent and caseous material. Severe fungal infestation by Aspergillus terreus was documented in the otic region but not in any other site of the body. Adjacent to the promontorium, massive accumulation of fibrinous secretion and infiltration of clusters of inflammatory cells were present. Newly formed cysts and vessels replaced the round window membrane location, remin...

Combined use of fluconazole and selective digestive decontamination in the prevention of fungal infection after adult liver transplantation

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Decruyenaere J, Colardyn F, Vogelaers D, Claeys G, Hesse U, De Deyne C, Hoste E, Lutz-Dettinger N, Vandewoude K, de Hemptinne B (Source: The Aspergillus Website - articles)

Risk factors for systemic fungal infections in liver transplant recipients

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Briegel J, Forst H, Spill B, Haas A, Grabein B, Haller M, Kilger E, Jauch KW, Maag K, Ruckdeschel G, Peter K (Source: The Aspergillus Website - articles)

Primary cutaneous infection by Aspergillus ustus in a 62-year-old liver transplant recipient

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Stiller MJ, Teperman L, Rosenthal SA, Riordan A, Potter J, Shupack JL, Gordon MA (Source: The Aspergillus Website - articles)

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Bacterial and fungal colonization and infections using oral selective bowel decontamination in orthotopic liver transplantations

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Steffen R, Reinhartz O, Blumhardt G, Bechstein WO, Raakow R, Langrehr JM, Rossaint R, Slama K, Neuhaus P (Source: The Aspergillus Website - articles)

Fungal infections in liver transplant recipients

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Grauhan O, Lohmann R, Lemmens P, Schattenfroh N, Keck H, Klein E, Raakow R, Jonas S, Langrehr JM, Bechstein W, Blumhardt, Neuhaus P (Source: The Aspergillus Website - articles)

Risk factors for invasive fungal infections complicating orthotopic liver transplantation

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Collins LA, Samore MH, Roberts MS, Luzzati R, Jenkins RL, Lewis WD, Karchmer AW (Source: The Aspergillus Website - articles)

Surgical wound infection by Aspergillus fumigatus in liver transplant recipients

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Plá MP, Berenguer J, Arzuaga JA, Bañares R, Polo JR, Bouza E (Source: The Aspergillus Website - articles)

Factors associated with invasive lung aspergillosis and the significance of positive Aspergillus culture after liver transplantation

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Kusne S, Torre-Cisneros J, Mañez R, Irish W, Martin M, Fung J, Simmons RL, Starzl TE (Source: The Aspergillus Website - articles)

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The spectrum of aspergillosis in liver transplant patients: comparison of FK 506 and cyclosporine immunosuppression

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Torre-Cisneros J, Mañez R, Kusne S, Alessiani M, Martin M, Starzl TE (Source: The Aspergillus Website - articles)

Spectrum and risk factors for invasive candidiasis and non-Candida fungal infections after liver transplantation

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Shi SH, Lu AW, Shen Y, Jia CK, Wang WL, Xie HY, Zhang M, Liang TB, Zheng SS (Source: The Aspergillus Website - articles)

Analysis of severe infections (INF) after 180 consecutive liver transplants: the impact of amphotericin B prophylaxis for reducing the incidence and severity of fungal infections

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Mora NP, Cofer JB, Solomon H, Goldstein RM, Gonwa TA, Husberg BS, Klintmalm GB (Source: The Aspergillus Website - articles)

Fungal infections in solid-organ transplantation

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Paya CV (Source: The Aspergillus Website - articles)

Clinical spectrum of fungal infections after orthotopic liver transplantation

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Castaldo P, Stratta RJ, Wood RP, Markin RS, Patil KD, Shaefer MS, Langnas AN, Reed EC, Li SJ, Pillen TJ, Shaw B (Source: The Aspergillus Website - articles)

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Purification and characterization of the exopolygalacturonase produced by Aspergillus giganteus in submerged cultures.

Journal of Industrial Microbiology and Biotechnology — Thu, 04 Mar 2010 00:00:00 +0100

We present here an efficient, simple, and inexpensive method for purifying the A. giganteus PG and describe the characteristics of the purified enzyme. Purified PG was obtained after two simple steps: (1) protein precipitation with 70% ammonium sulfate saturation and (2) anion-exchange chromatography on a DEAE-Sephadex A-50 column. The final enzyme solution retained 86.4% of its initial PG activity. The purified PG had a molecular weight of 69.7 kDa, exhibited maximal activity at pH 6.0 and 55-60 degrees C, and was stable in neutral and alkaline media. It had a half-life of 115, 18, and 6 min at 40, 50 and 55 degrees C, respectively. Purified PG showed its highest hydrolytic activity with low-esterified and nonesterified substrates, releasing monogalacturonic acid from substrate, indicatin...

Inhibition of neutrophil function following exposure to the Aspergillus fumigatus toxin, fumagillin.

Journal of Medical Microbiology — Thu, 04 Mar 2010 00:00:00 +0100

Authors: Fallon JP, Reeves EP, Kavanagh KA The filamentous fungus Aspergillus fumigatus produces a variety of enzymes and toxins that may facilitate fungal colonization of tissue and evasion of the host immune response. One such toxin, fumagillin, was investigated for its ability to inhibit the action of neutrophils which are a central component of the innate immune response to microbial infection. Neutrophils exposed to 2 ?g fumagillin ml-1 for 25 minutes showed a significantly reduced ability to kill yeast cells (p < 0.02), to phagocytose conidia of A. fumigatus (p < 0.023) and to consume oxygen (p < 0.032). The ability of neutrophils to generate superoxide is dependent upon the action of a functional NADPH oxidase complex which is composed of cytosolic (p40phox, p47phox, p6...

Murine models of airway fungal exposure and allergic sensitization

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Templeton SP, Buskirk AD, Green BJ, Beezhold DH, Schmechel D (Source: The Aspergillus Website - articles)

Aspergillus nidulans UDP-glucose-4-epimerase UgeA has multiple roles in wall architecture, hyphal morphogenesis, and asexual development.

Fungal Genetics and Biology — Thu, 04 Mar 2010 00:00:00 +0100

Authors: El-Ganiny AM, Sheoran I, Sanders DA, Kaminskyj SG Aspergillus nidulans UDP-glucose-4-epimerase UgeA interconverts UDP-glucose and UDP-galactose and participates in galactose metabolism. The sugar moiety of UDP-galactose is predominantly found as galactopyranose (Galp, the six-membered ring form), which is the substrate for UDP-galactopyranose mutase (encoded by ugmA) to generate UDP-galactofuranose (Galf, the five-membered ring form) that is found in fungal walls. In A. fumigatus, Galf residues appear to be important for virulence. The A. nidulans ugeADelta strain is viable, and has defects including wide, slow growing, highly branched hyphae and reduced conidiation that resemble the ugmADelta strain. As for the ugmADelta strain, ugeADelta colonies had substantially reduced sp...

Aspergillus oryzae flavohemoglobins promote oxidative damage by hydrogen peroxide.

Biochemical and Biophysical Research communications — Thu, 04 Mar 2010 00:00:00 +0100

This study is the first to show that fungal FHbs have a deleterious effect on oxidative protection, and suggests that the accelerated Fenton reaction induced by FHbs might be responsible for this effect. PMID: 20211603 [PubMed - as supplied by publisher] (Source: Biochemical and Biophysical Research communications)

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Murine models of airway fungal exposure and allergic sensitization

The Aspergillus Website - articles — Thu, 04 Mar 2010 00:00:00 +0100

Templeton SP, Buskirk AD, Green BJ, Beezhold DH, Schmechel D (Source: The Aspergillus Website - articles)

In vitro and in vivo antifungal activities of aminopiperidine derivatives, novel ergosterol synthesis inhibitors.

Biological and Pharmaceutical Bulletin — Wed, 03 Mar 2010 07:28:05 +0100

Authors: Hata M, Yoshida K, Ishii C, Otani T, Ando A Aminopiperidine derivatives, Compound 1a and 1b, are novel small molecules that inhibit C-14 reduction catalyzed by Erg24p in ergosterol synthesis of Candida albicans. We evaluated the properties of the in vitro and in vivo activities of these compounds against pathogenic fungi and compared their activities with those of fluconazole. Compound 1a and 1b exhibited potent in vitro activities against clinically important fungi such as Candida species, including both of fluconazole-resistant strains of C. albicans and non-albicans Candida, Aspergillus fumigatus, and Cryptococcus neoformans. Against C. albicans, its mode of action was fungistatic. Furthermore, orally administered Compound 1b clearly prolonged the survival of infected mice ...

Galactomannan testing of bronchoalveolar lavage fluid is useful for diagnosis of invasive pulmonary aspergillosis in hematology patients

BMC Infectious Diseases — Wed, 03 Mar 2010 00:00:00 +0100

Conclusions: Our results also support BAL galactomannan testing as a reasonably safe test with higher sensitivity compared to serum galactomannan testing in at-risk patients with hematological diseases. A higher OD cutoff is necessary to avoid over-diagnosis of IPA, and a standardized method of collection should be established before results can be compared between centers. (Source: BMC Infectious Diseases)

Mycotic sinusitis in children

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Laskownicka Z, Kurdzielewicz J, Macura A, Okrasińska-Cholewa B (Source: The Aspergillus Website - articles)

Fungal maxillary sinusitis (article in French)

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Grigoriu D, Bambule J, Delacrétaz J, Savary M (Source: The Aspergillus Website - articles)

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Endoscopic surgery for mycotic and chronic recurring sinusitis

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Stammberger H (Source: The Aspergillus Website - articles)

Aspergillusmykose der Keiferhohle

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Zarniko C (Source: The Aspergillus Website - articles)

Efficacy of galactomannan antigen in the Platelia Aspergillus enzyme immunoassay for diagnosis of invasive aspergillosis in liver transplant recipients

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Kwak EJ, Husain S, Obman A, Meinke L, Stout J, Kusne S, Wagener MM, Singh N (Source: The Aspergillus Website - articles)

Aspergillosis of the central nervous system: a catastrophic opportunistic infection

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Pongbhaesaj P, Dejthevaporn C, Tunlayadechanont S, Witoonpanich R, Sungkanuparph S, Vibhagool A (Source: The Aspergillus Website - articles)

Aspergillusmykose der Keiferhöhle

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Zarniko C (Source: The Aspergillus Website - articles)

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Aspergillus fumigatus necrotizing meningo-encephalitis following a road accident with open depressed fracture of the skull (article in French)

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Guiot P, Kummerlen C, Gutbub AM, Laplatte G, Plas JY, Haegy JM (Source: The Aspergillus Website - articles)

Carotid-cavernous sinus thrombosis caused by Aspergillus fumigatus: magnetic resonance imaging with pathologic correlation - a case report

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Dyken ME, Biller J, Yuh WT, Fincham R, Moore SA, Justin E (Source: The Aspergillus Website - articles)

Prevention of invasive fungal infections in liver transplant recipients: the role of prophylaxis with lipid formulations of amphotericin B in high-risk patients

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Fortún J, Martín-Davila P, Moreno S, Barcena R, de Vicente E, Honrubia A, García M, Nuño J, Candela A, Uriarte M, Pintado V (Source: The Aspergillus Website - articles)

Efficacy and safety of itraconazole prophylaxis for fungal infections after orthotopic liver transplantation: a prospective, randomized, double-blind study

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Sharpe MD, Ghent C, Grant D, Horbay GL, McDougal J, David Colby W (Source: The Aspergillus Website - articles)

Trends in risk profiles for and mortality associated with invasive aspergillosis among liver transplant recipients

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Singh N, Avery RK, Munoz P, Pruett TL, Alexander B, Jacobs R, Tollemar JG, Dominguez EA, Yu CM, Paterson DL, Husain S, Kusne S, Linden P (Source: The Aspergillus Website - articles)

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Antifungal prophylaxis in liver transplant recipients: a randomized placebo-controlled study

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Biancofiore G, Bindi ML, Baldassarri R, Romanelli AM, Catalano G, Filipponi F, Vagelli A, Mosca F (Source: The Aspergillus Website - articles)

Randomized controlled trial of oral itraconazole solution versus intravenous/oral fluconazole for prevention of fungal infections in liver transplant recipients

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Winston DJ, Busuttil RW (Source: The Aspergillus Website - articles)

Trends in invasive fungal infections in liver transplant recipients: correlation with evolution in transplantation practices

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Singh N, Wagener MM, Marino IR, Gayowski T (Source: The Aspergillus Website - articles)

Preemptive prophylaxis with a lipid preparation of amphotericin B for invasive fungal infections in liver transplant recipients requiring renal replacement therapy

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Singh N, Paterson DL, Gayowski T, Wagener MM, Marino IR (Source: The Aspergillus Website - articles)

Aspergillus antigenemia sandwich-enzyme immunoassay test as a serodiagnostic method for invasive aspergillosis in liver transplant recipients

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Fortun J, Martin-Davila P, Alvarez ME, Sanchez-Sousa A, Quereda C, Navas E, Barcena R, Vicente E, Candelas A, Honrubia A, Nuño J, Pintado V, Moreno S; Ramon y Cajal Hospital's Liver Transplant Group (Source: The Aspergillus Website - articles)

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Pulmonary disease in liver transplant recipients. Spectrum of CT features

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Knollmann FD, Mäurer J, Bechstein WO, Vogl TJ, Neuhaus P, Felix R (Source: The Aspergillus Website - articles)

Pulmonary infiltrates in liver transplant recipients in the intensive care unit

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Singh N, Gayowski T, Wagener MM, Marino IR (Source: The Aspergillus Website - articles)

Systemic mycoses during prophylactical use of liposomal amphotericin B (Ambisome) after liver transplantation

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Lorf T, Braun F, Rüchel R, Müller A, Sattler B, Ringe B (Source: The Aspergillus Website - articles)

Pulmonary nodules in liver transplant recipients

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Paterson DL, Singh N, Gayowski T, Marino IR (Source: The Aspergillus Website - articles)

Invasive aspergillosis in liver transplant recipients in the 1990s

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Singh N, Arnow PM, Bonham A, Dominguez E, Paterson DL, Pankey GA, Wagener MM, Yu VL (Source: The Aspergillus Website - articles)

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Brain abscess in solid organ transplant recipients receiving cyclosporine-based immunosuppression

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Selby R, Ramirez CB, Singh R, Kleopoulos I, Kusne S, Starzl TE, Fung J (Source: The Aspergillus Website - articles)

Cytokine pattern during rejection and infection after liver transplantation - improvements in postoperative monitoring

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Platz KP, Mueller AR, Rossaint R, Steinmüller T, Lemmens HP, Lobeck H, Neuhaus P (Source: The Aspergillus Website - articles)

Risk factors of invasive Candida and non-Candida fungal infections after liver transplantation

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Patel R, Portela D, Badley AD, Harmsen WS, Larson-Keller JJ, Ilstrup DM, Keating MR, Wiesner RH, Krom RA, Paya CV (Source: The Aspergillus Website - articles)

Survival of a liver graft recipient treated for an aspergillar liver abscess

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Mazza D, Gugenheim J, Toouli J, Mouiel J (Source: The Aspergillus Website - articles)

Randomized trial of fluconazole versus nystatin for the prophylaxis of Candida infection following liver transplantation

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Lumbreras C, Cuervas-Mons V, Jara P, del Palacio A, Turrión VS, Barrios C, Moreno E, Noriega AR, Paya CV (Source: The Aspergillus Website - articles)

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Prophylaxis with liposomal amphotericin B (AmBisome) prevents fungal infections in liver transplant recipients: long-term results of a randomized, placebo-controlled trial

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Tollemar J, Höckerstedt K, Ericzon BG, Jalanko H, Ringdén O (Source: The Aspergillus Website - articles)

Liposomal amphotericin B prevents invasive fungal infections in liver transplant recipients. A randomized, placebo-controlled study

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Tollemar J, Höckerstedt K, Ericzon BG, Jalanko H, Ringdén O (Source: The Aspergillus Website - articles)

Fluconazole prophylaxis for high-risk liver transplant recipients

The Aspergillus Website - articles — Wed, 03 Mar 2010 00:00:00 +0100

Kung N, Fisher N, Gunson B, Hastings M, Mutimer D (Source: The Aspergillus Website - articles)

Estrogenic Activity of Glyceollins Isolated from Soybean Elicited with Aspergillus sojae

Journal of Medicinal Food — Tue, 02 Mar 2010 03:18:38 +0100

Journal of Medicinal Food , Vol. 0, No. 0. (Source: Journal of Medicinal Food)

Degradation of Parabens by Pseudomonas beteli and Burkholderia latens.

European Journal of Pharmaceutics and Biopharmaceutics — Tue, 02 Mar 2010 00:00:00 +0100

Authors: Amin A, Dare SC, Bansal AK p-Hydroxybenzoic acid esters (parabens) are commonly used antimicrobial preservatives in pharmaceutical formulations. Two microorganisms, isolated from non-sterile methyl paraben (MP) and propyl paraben (PP) solutions, were found to degrade the respective parabens. Identification by 16S rRNA partial gene sequencing revealed them to be Pseudomonas beteli and Burkholderia latens, respectively. The present work describes a previously unreported interaction of the parabens with Pseudomonas beteli and Burkholderia latens. Degradation of MP at various concentrations by Pseudomonas beteli, followed a logarithmic pattern, while that of PP by Burkholderia latens, was found to be linear. It was subsequently observed that Pseudomonas beteli could degrade only M...

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Effect of reduced water activity and reduced matric potential on the germination of xerophilic and non-xerophilic fungi.

International Journal of Food Microbiology — Tue, 02 Mar 2010 00:00:00 +0100

This study reports the effect of reduced a(w) and reduced Psi(m) on the germination of xerophilic fungi (represented by Eurotium herbariorum) and non-xerophilic fungi (represented by Aspergillus niger) on model glycerol agar media. Germination curves were plotted with the percentage of germinated spores against time. The germination time (t(G)), which is defined as the time at which 50% of the total viable spores have germinated, was estimated using the Gompertz model. Total viable spores was defined as those spores that were able to germinate under the optimum a(w) and Psi(m) conditions for each species, i.e. 0.95 a(w) and 2.5% agar for E. herbariorum and 0.98 a(w) and 2.5% agar for A. niger. As a(w) decreased from 0.90 to 0.85 a(w), t(G) increased significantly for both the xerophilic fu...

Methylprednisolone: Aspergillus endophthalmitis in a liver transplant recipient: case report

Reactions — Mon, 01 Mar 2010 14:50:10 +0100

(Source: Reactions)

Cavitary pulmonary lesion associated with Aspergillus fumigatus infection in a German shepherd dog

The Journal of Small Animal Practice — Mon, 01 Mar 2010 00:00:00 +0100

A two-year-old female German shepherd dog was presented with chronic cough and haemoptysis. Thoracic radiographs revealed a thin-walled cavitary lesion within a consolidated left cranial lung lobe. Bronchoalveolar lavage confirmed a concurrent bacterial infection; however, despite antibiotic and anthelmintic therapy the clinical signs failed to resolve. A left cranial lung lobectomy was performed. Histopathology and fungal culture confirmed the presence of Aspergillus fumigatus. The necrotic cavity had features compatible with a bronchial origin, possibly a form of cystic bronchiectasis, arising either as a congenital anomaly or acquired secondary to infection. Surgery provided resolution of clinical signs for just over a year before the dog deteriorated again and was subsequently euthanis...

The Use of High-Resolution Melt to Characterize Codon 54 of the cyp51A Gene of Aspergillus fumigatus on the Rotor-GeneTM 6000.

Antimicrobial Agents and Chemotherapy — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Tuohy MJ, Reja V, Park S, Perlin DS, Wnek M, Procop GW, Yen-Lieberman B A High-resolution melt (HRM) assay using the Rotor-Gene 6000(TM) was developed to characterize the codon for glycine 54 in the cyp51A gene from 13 reference and 12 clinical isolates of Aspergillus fumigatus. Mutations in this codon confer reduced susceptibility to itraconazole and posaconazole. The assay is simple to perform and a result of wildtype or mutant is available after approximately one hour following DNA extraction using commercially available reagents and conventional primers. PMID: 20194699 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)

Primary Super-Infection of Hydatid Cyst--Clinical Setting and Microbiology in 37 Cases.

The American Journal of Tropical Medicine and Hygiene — Mon, 01 Mar 2010 00:00:00 +0100

Authors: García MB, Lledías JP, Pérez IG, Tirado VV, Pardo LF, Bellvís LM, Varela G, Sánchez MC The clinical and microbiological characteristics of super-infected hydatid cysts are described. In our cohort, 7.3% of 503 patients had a super-infected cyst. Four patients developed severe sepsis, and two of them died. Escherichia coli, viridans group streptococci, and Enterococcus species in liver cysts and Aspergillus fumigatus in lung cysts were the microorganisms most frequent involved. PMID: 20207859 [PubMed - as supplied by publisher] (Source: The American Journal of Tropical Medicine and Hygiene)

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Lung scedosporiosis in human immunodeficiency virus/acquired immunodeficiency syndrome.

The American Journal of the Medical Sciences — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Sarva ST, Manjunath SK, Baldwin HS, Robins DB, Freire AX A 31-year-old African American woman with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) (recent CD4 count of 66/mm) presented to the emergency room with a tension pneumothorax that required an emergent chest tube placement. Computed tomography scan showed fungus balls in multiple lung cavities and surrounding infiltrates. The patient showed remarkable improvement with voriconazole suggesting aspergillosis. However, the patient was serologically negative for Aspergillus and other common fungal infections. Because of a persistent air leak, surgical intervention was needed. The histological finding was consistent with invasive mycosis, and cultures were positive for Scedosporium apiospermum. Lit...

Onychomycosis in iran: epidemiology, causative agents and clinical features.

Nippon Ishinkin Gakk... — Sat, 27 Feb 2010 11:52:03 +0100

Conclusions: The clinico-epidemiological data collected can serve as reference for future research and may be useful in the development of preventive and educational strategies. PMID: 20185868 [PubMed - in process] (Source: Nippon Ishinkin Gakk...)

The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes

Nucleic Acids Research — Sat, 27 Feb 2010 05:17:06 +0100

The heterotrimeric CCAAT-binding complex is evolutionary conserved in eukaryotic organisms. The corresponding Aspergillus nidulans CCAAT- binding factor (AnCF) consists of the subunits HapB, HapC and HapE. All of the three subunits are necessary for DNA binding. Here, we demonstrate that AnCF senses the redox status of the cell via oxidative modification of thiol groups within the histone fold motif of HapC. Mutational and in vitro interaction analyses revealed that two of these cysteine residues are indispensable for stable HapC/HapE subcomplex formation and high-affinity DNA binding of AnCF. Oxidized HapC is unable to participate in AnCF assembly and localizes in the cytoplasm, but can be recycled by the thioredoxin system in vitro and in vivo. Furthermore, deletion of the hapC gene led ...

Synthesis of new 4-methyl-2-(4-pyridyl)-1,2,3,4-tetrahydroquinolines as potent antifungal compounds

Journal of the Brazilian Chemical Society — Fri, 26 Feb 2010 16:18:31 +0100

Synthesis, spectral characterization and biological results of new series of 2-(4-pyridyl)-1,2,3,4-tetrahydroquinolines and their closer precursors, -N-aryl-N-[1-(4-pyridyl)but-3-enyl]amines are reported. It was found that both γ-pyridyl substituted precursors and final products, tetrahydroquinolines, showed very good antifungal activities against Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Microsporum gypseun, Trichophyton rubrum and Trichophyton mentagrophytes.A síntese, a caracterização espectroscópica e os resultados biológicos de novas séries de 2-(4-piridil)-1,2,3,4-tetrahidroquinolinas e seus precursores, -N-aril-N-[1-(4-piridil)but-3-enil]aminas, são descritos. Foi encontrado que ambos, precursores substituídos γ-piridil e os produtos finais, as tetrahid...