MedWorm: Bocavirus

Human bocavirus infections in hospitalized Greek children

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:13:09 +0100

Conclusions: HBoV infections occur in Greece mostly among very young children. They accounted for 3.2% of children hospitalized with acute respiratory disease. Cases were observed only in late autumn to early spring. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

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Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year prospective study

Acta Paediatrica — Wed, 17 Feb 2010 00:00:00 +0100

Conclusions: In hospitalized infants, RSV was the most frequent agent in bronchiolitis in winter, but other viruses were present in 47% of the patients. RV, HBoV and hMPV had a significant proportion of single infections. Clinical characteristics were similar amongst them, but seasonality was clearly different. (Source: Acta Paediatrica)

[Consensus conference on acute bronchiolitis (II): epidemiology of acute bronchiolitis. Review of the scientific evidence.]

Anales de Pediatria — Thu, 11 Feb 2010 00:00:00 +0100

Authors: Ochoa Sangrador C, González de Dios J, A review of the evidence on epidemiology, risk factors, etiology and clinical-etiological profile of acute bronchiolitis is presented. The frequency estimates are very heterogeneous; in the population under two years the frequency of admission for bronchiolitis is between 1 and 3.5%, primary care consultations between 4 and 20% and emergency visits between 1 and 2%. The frequency of admissions for respiratory infection by respiratory syncytial virus in the risk population is: in premature infants </=32 weeks of gestation between 4.4 and 18%, in patients with bronchopulmonary dysplasia between 7.3 and 42%, and in infants with congenital heart disease between 1.6 and 9.8%. The main risk factors are: prematurity, chronic lung diseas...

A novel multiplex real-time rt-pcr assay with fret hybridization probes for the detection and quantitation of 13 respiratory viruses.

Journal of Virological Methods — Wed, 10 Feb 2010 00:00:00 +0100

A NOVEL MULTIPLEX REAL-TIME RT-PCR ASSAY WITH FRET HYBRIDIZATION PROBES FOR THE DETECTION AND QUANTITATION OF 13 RESPIRATORY VIRUSES. J Virol Methods. 2010 Feb 10; Authors: Lassauniére R, Kresfelder T, Venter M Quantitative multiplex real-time RT-PCR assays utilizing fluorescence resonance energy transfer (FRET) hybridization probes were developed for the detection of 13 respiratory viruses, including well recognized viral causes (respiratory syncytial virus, influenza viruses A and B, parainfluenza viruses types 1, 2, and 3, adenovirus) as well as viruses described recently as causes of acute respiratory tract infections (human coronaviruses NL63, HKU1, 229E, and OC43, human bocavirus, and human metapneumovirus). FRET probes have an improved toleration for single base mis...

Erratum: Human bocavirus: Increasing evidence for virulence

Pediatric Pulmonology — Tue, 09 Feb 2010 00:00:00 +0100

No Abstract. (Source: Pediatric Pulmonology)

Novel human bocavirus in children with acute respiratory tract infection.

Emerging Infectious Diseases — Mon, 01 Feb 2010 00:00:00 +0100

Authors: Song JR, Jin Y, Xie ZP, Gao HC, Xiao NG, Chen WX, Xu ZQ, Yan KL, Zhao Y, Hou Y, Duan ZJ Human bocavirus (HBoV) and HBoV2, two human bocavirus species, were found in 18 and 10 of 235 nasopharyngeal aspirates, respectively, from children hospitalized with acute respiratory tract infection. Our results suggest that, like HBoV, HBoV2 is distributed worldwide and may be associated with respiratory and enteric diseases. PMID: 20113572 [PubMed - in process] (Source: Emerging Infectious Diseases)

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Human bocavirus in children with respiratory tract infection in Shanghai: a retrospective study.

World Journal of Pediatrics : WJP — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: HBoV was circulating in Shanghai during the study period, and which was detected frequently in children with ARTI. HBoV was found to be associated with community-acquired ARTI and may play a pathogenic role in nosocomial ARTI. PMID: 20143214 [PubMed - in process] (Source: World Journal of Pediatrics : WJP)

Hematopoietic cell transplantation and emerging viral infections

Journal of Medical Virology — Tue, 19 Jan 2010 00:00:00 +0100

This article summarizes recent data on epidemiology and laboratory diagnosis of new pathogens, as well as clinical features and management of the associated infectious complications. J. Med. Virol. 82:528-538, 2010. © 2010 Wiley-Liss, Inc. (Source: Journal of Medical Virology)

Novel Human Bocavirus in Children with Acute Respiratory Tract Infection, J. Song et al.

Emerging Infectious Diseases Journal — Wed, 13 Jan 2010 19:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants

Archives of Disease in Childhood — Tue, 29 Dec 2009 18:48:52 +0100

Conclusions: Although the major pathogen responsible for bronchiolitis remains RSV, the infection can also be caused by RV and hBoV. Demographic characteristics and clinical severity of the disease may depend on the number of viruses or on the specific virus detected. (Source: Archives of Disease in Childhood)

Newly recognized bocaviruses (HBoV, HBoV2) in children and adults with gastrointestinal illness in the United States

Journal of Clinical Virology — Mon, 28 Dec 2009 00:00:00 +0100

Conclusions: The newly recognized parvovirus HBoV2 circulates in the United States. Patients with bocaviruses in stool have evidence of gastrointestinal illness. HBoV2 was not detected in respiratory samples. HBoV3 was not detected in either stool or respiratory samples. (Source: Journal of Clinical Virology)

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Parvovirus 4 in blood donors, france.

Emerging Infectious Diseases — Sat, 26 Dec 2009 06:50:22 +0100

Authors: Touinssi M, Brisbarre N, Picard C, Frassati C, Dussol B, Uch R, Gallian P, Cantaloube JF, Micco P, Biagini P To the Editor: In the past few years, several novel parvoviruses have been identified, including human parvovirus B19-related strains V9 and A6, and bocavirus. In 2005, parvovirus 4 (PARV4), a new putative member of the family Parvoviridae, was identified in the plasma of a patient in North America who had an acute virus infection (1). This virus had limited sequence homology with parvovirus B19 (<30% aa similarity) despite a conserved genomic organization showing 2 large nonoverlapping open reading frames (ORF). Phylogenetic studies performed with near-complete sequences have proposed that human PARV4 can be described by >/=3 genogroups (2). PMID: 20031076 [P...

Absence of human bocavirus from deceased fetuses and their mothers

Journal of Clinical Virology — Fri, 25 Dec 2009 00:00:00 +0100

Conclusions: We did not find HBoV DNA in any of the deceased fetuses. Almost all pregnant women were HBoV-IgG positive. (Source: Journal of Clinical Virology)

Human bocavirus infection in young children with acute respiratory tract infection in Lanzhou, China

Journal of Medical Virology — Tue, 22 Dec 2009 00:00:00 +0100

In this study, the epidemiological and virological characteristics of HBoV infection were studied in children with acute respiratory tract infection in China. In total, 406 children younger than 14 years of age with acute respiratory tract infection were included in this prospective 1-year study. HBoV was detected in 29 (7.1%) of the 406 children. No clear seasonal fluctuation was observed in infection rates of HBoV. Of the 29 children infected with HBoV, 16 (55.2%) were coinfected with other respiratory viruses, most commonly respiratory syncytial virus (RSV). Viral coinfection with HBoV did not affect the severity of the respiratory disease (P = 0.291). The number of HBoV genome copies ranged from 5.80 × 102 to 9.72 × 108 copies/ml in nasopharyngeal aspirates among HBoV-positive specim...

Correlation between bocavirus infection and humoral response, and co-infection with other respiratory viruses in children with acute respiratory infection

Journal of Clinical Virology — Fri, 18 Dec 2009 00:00:00 +0100

Conclusion: HBoV was found frequently in children with respiratory tract symptoms associated with other respiratory viruses, and persisted in the respiratory tract and in serum and urine. The presence of IgM was significantly more prevalent in viremic patients and those diagnosed with high load of HBoV DNA in nasal/throat swabs. (Source: Journal of Clinical Virology)

Serologically verified human bocavirus pneumonia in children

Pediatric Pulmonology — Thu, 03 Dec 2009 00:00:00 +0100

Human bocavirus (HBoV) is a newly identified parvovirus frequently found in children suffering from acute respiratory and intestinal infections. The aim of the present study was to evaluate, by using a newly developed antibody assay, the role of HBoV in pediatric community-acquired pneumonia (CAP) and the seropositivity rate to HBoV in a prospective study in North-Italian children.During a 15-month study period, 124 children were admitted due to presumptive pneumonia, and in 101 of them, pneumonia was radiologically confirmed. The etiology of CAP was studied by antibody assays to 16 microbes, including the newly developed enzyme immunoassay for HBoV.Serological evidence of acute HBoV infection was found in 12 (12%) children, being single in 7 and mixed in 5 cases (4 with other viruses and ...

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Antibodies against structural (VP1 and VP2) and nonstructural (NP-1 and NS1) proteins of human bocavirus in human sera.

Clinical and Vaccine Immunology — Wed, 02 Dec 2009 00:00:00 +0100

Authors: Shirkoohi R, Endo R, Ishiguro N, Teramoto S, Kikuta H, Ariga T Immunofluorescence assays (IFAs) for detection of HBoV proteins (VP1, VP2, NP-1 and NS1) were developed. VP1-IFA was the most sensitive for detection of IgG antibody and suitable for screening. IgG antibodies in convalescent-phase sera of HBoV-positive patients were detected by VP1- and VP2-IFAs. Sensitivities of NP-1- and NS1-IFAs were low. PMID: 19955324 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)

Rapid molecular evolution of human bocavirus revealed by Bayesian coalescent inference.

Infection, Genetics and Evolution — Thu, 19 Nov 2009 00:00:00 +0100

Authors: Zehender G, De Maddalena C, Canuti M, Zappa A, Amendola A, Lai A, Galli M, Tanzi E Human bocavirus (HBoV) is a linear single-stranded DNA virus belonging to the Parvoviridae family that has recently been isolated from the upper respiratory tract of children with acute respiratory infection. All of the strains observed so far segregate into two genotypes (1 and 2) with a low level of polymorphism. Given the recent description of the infection and the lack of epidemiological and molecular data, we estimated the virus's rates of molecular evolution and population dynamics. A dataset of forty-nine dated VP2-sequences, including also eight new isolates obtained from pharyngeal swabs of Italian patients with acute respiratory tract infections, was submitted to phylogenetic analysis....

The Human Bocaviruses: A Review and Discussion of Their Role in Infection

Clinics in Laboratory Medicine — Wed, 04 Nov 2009 16:51:33 +0100

This article is a comprehensive review of what is known about HBoV. It includes an evaluation of diagnostic modalities, symptoms occurring in affected patients, and a discussion as to whether HBoV is responsible for identified clinical manifestations. The article reviews the incidence and effect of coinfection and updates on related members (HBoV-2 and HBoV-3) recently reported. Understanding of respiratory viruses such as HBoV remains vitally important to the health of adult and pediatric patients. (Source: Clinics in Laboratory Medicine)

Prevalence of Parvovirus B19 and Human Bocavirus DNA in the Heart of Patients with no Evidence of Dilated Cardiomyopathy or Myocarditis

Clinical Infectious Diseases Latest Issue — Wed, 28 Oct 2009 21:20:48 +0100

Conclusions. Our data suggest that B19V but not HBoV demonstrates a lifelong persistence in the heart. The detection of B19V DNA in heart tissue showed no correlation with clinical symptoms. We strongly recommend that serological testing become a standardized procedure for future studies, to obtain representative data concerning the prevalence of B19V in the heart. (Source: Clinical Infectious Diseases Latest Issue)

Detection of Human Bocavirus-2 in children with acute Gastroenteritis in South Korea

Archives of Virology — Wed, 28 Oct 2009 07:22:20 +0100

Abstract Human bocavirus (HBoV)-2, a new parvovirus, has been identified in stool samples and is suggested to be one of the etiologic agents of acute gastroenteritis (GE). The purpose of this study was to investigate the prevalence of HBoV-2 in children with GE. Stool samples were collected from 358 children hospitalized with GE. HBoV-2 was detected in 3.6% of the patients. HBoV-2 was co-detected with other viral agents in 53.8% of the patients. These findings suggest that HBoV-2 may be an etiologic agent in GE, but further studies are needed due to frequent co-detection with other enteric viruses. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s00705-009-0533-3Authors Tae-Hee Han, Inje University College of Medicine Department of Laboratory Medicine, Sang...

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Human bocavirus 2 in children, South Korea.

Emerging Infectious Diseases — Thu, 01 Oct 2009 00:00:00 +0100

Authors: Han TH, Chung JY, Hwang ES To the Editor: In 2009, Kapoor et al. and Arthur et al. published reports on the prevalence of the newly identified parvovirus, human bocavirus 2 (HBoV-2), in fecal samples (1,2). HBoV-1 had been discovered in 2005 (3), and reports indicate its possible role in respiratory diseases such as upper respiratory tract infections, lower respiratory tract infections (LRTIs), and in exacerbation of asthma (4); in these diseases, the virus co-infects with other respiratory viruses (5). Systemic infection with HBoV-1 and possible association of this virus with other diseases such as gastroenteritis, Kawasaki disease, and hepatitis have been reported (6-8). We looked for HBoV-2 in clinical samples from children with various diseases, including acute LRTIs, Kawa...

Sequence analysis of an isolate of minute virus of canines in China reveals the closed association with bocavirus.

Molecular Biology Reports — Wed, 16 Sep 2009 23:00:00 +0100

Authors: Shan TL, Cui L, Dai XQ, Guo W, Shang XG, Yu Y, Zhang W, Kang YJ, Shen Q, Yang ZB, Zhu JG, Hua XG In the present study, we have cloned and sequenced the nearly-full-length genome of minute virus of canines (MVC), SH26, in China. The genome of MVC, 5,132 nucleotides (nts) in length, contains three open reading frames (ORFs), which are 2,325-bp of NS1, 561-bp of NP1 and 2,112-bp of VP1/VP2 encoding three proteins of 774, 186 and 703 residues, respectively. Predicted amino acids sequence of NS1 of MVC has 44% identity with human bocavirus (HBoV) and human boacvirus 2 (HBoV2), NP1 has 48 and 45% identity with HBoV and HBoV2, VP1/VP2 has 45 and 46% identity with HBoV and HBoV2, respectively. Phylogenetic analysis showed that the present Chinese MVC strain was also closely clustered ...

Human bocavirus and rhino-enteroviruses in childhood otitis media with effusion

Journal of Clinical Virology — Sun, 06 Sep 2009 23:00:00 +0100

Conclusions: Our results suggest that these common respiratory viruses can be associated with OME in children. Whether these viruses are causative etiologic factors of MEE persistence or merely remnants of previous infections is not known. (Source: Journal of Clinical Virology)

Absence of detectable replication of human bocavirus species 2 in respiratory tract.

Emerging Infectious Diseases — Mon, 31 Aug 2009 23:00:00 +0100

Authors: Chieochansin T, Kapoor A, Delwart E, Poovorawan Y, Simmonds P Human bocavirus (HBoV) commonly infects young children and is associated with respiratory disease; disease associations of the divergent HBoV-2 species are unknown. Frequent HBoV-2 detection in fecal samples indicated widespread circulation in the United Kingdom and Thailand, but its lack of detection among 6,524 respiratory samples indicates likely differences from HBoV-1 in tropism/pathogenesis. PMID: 19788826 [PubMed - in process] (Source: Emerging Infectious Diseases)

Clinical assessment and improved diagnosis of bocavirus-induced wheezing in children, Finland.

Emerging Infectious Diseases — Mon, 31 Aug 2009 23:00:00 +0100

Authors: Söderlund-Venermo M, Lahtinen A, Jartti T, Hedman L, Kemppainen K, Lehtinen P, Allander T, Ruuskanen O, Hedman K Human bocavirus (HBoV) is a widespread respiratory virus. To improve diagnostic methods, we conducted immunoglobulin (Ig) G and IgM enzyme immunoassays with recombinant virus-like particles of HBoV as antigen. Acute-phase and follow-up serum samples from 258 wheezing children and single serum samples from 115 healthy adults in Finland were examined. Our assays had a sensitivity of 97% and a specificity of 99.5%. Of adults, 96% had immunity; none had an acute infection. Of 48 children with serologically diagnosed acute HBoV infections, 45 were viremic and 35 had virus in nasopharyngeal aspirates (NPAs). Of 39 HBoV NPA PCR-positive children co-infected with anoth...

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Simultaneous detection of human bocavirus and adenovirus by multiplex real-time PCR in a Belgian paediatric population.

Adv Data — Mon, 24 Aug 2009 23:00:00 +0100

Authors: De Vos N, Vankeerberghen A, Vaeyens F, Van Vaerenbergh K, Boel A, De Beenhouwer H Since the discovery of human bocavirus (hBoV), the virus has been detected worldwide in respiratory tract samples from young children by various polymerase chain reaction (PCR) assays and real-time PCRs (Q-PCR). Until now, no data have been reported on the presence of hBoV in Belgium and the detection of hBoV in a multiplex Q-PCR setting has not been described. The aim of this study was to develop a fast and reliable multiplex Q-PCR for the simultaneous detection of hBoV DNA and adenovirus (AdV) DNA. During the winter of 2004-2005, 445 nasopharyngeal aspirates (NPAs) were analysed from 404 Belgian children up to 5 years old with acute respiratory tract infections (ARTIs). (Co)infections with hBoV...

Simultaneous detection of human bocavirus and adenovirus by multiplex real-time PCR in a Belgian paediatric population

European Journal of Clinical Microbiology & Infectious Diseases — Mon, 24 Aug 2009 16:53:14 +0100

Abstract Since the discovery of human bocavirus (hBoV), the virus has been detected worldwide in respiratory tract samples from young children by various polymerase chain reaction (PCR) assays and real-time PCRs (Q-PCR). Until now, no data have been reported on the presence of hBoV in Belgium and the detection of hBoV in a multiplex Q-PCR setting has not been described. The aim of this study was to develop a fast and reliable multiplex Q-PCR for the simultaneous detection of hBoV DNA and adenovirus (AdV) DNA. During the winter of 2004–2005, 445 nasopharyngeal aspirates (NPAs) were analysed from 404 Belgian children up to 5 years old with acute respiratory tract infections (ARTIs). (Co)infections with hBoV, AdV, respiratory syncytial virus (RSV), human metapneumoviru...

The first detection of human bocavirus 2 infections in China

Journal of Clinical Virology — Tue, 11 Aug 2009 23:00:00 +0100

Human bocavirus (HBoV) was firstly discovered in children with respiratory tract infections (RTIs), but also has been found in children with gastroenteritis. The association between HBoV and respiratory infections and gastroenteritis are determined. Human bocavirus 2 (HBoV2), which is one species of the subfamily Parvovirinae of the family Parvoviridae, was firstly reported in children by Kapoor et al. To extend these initial findings and assess the pathogenicity of HBoV and HBoV2, we investigated their prevalence in children in China. (Source: Journal of Clinical Virology)

Prevalence and clinical aspects of human bocavirus infection in children

Clinical Microbiology and Infection — Mon, 03 Aug 2009 23:00:00 +0100

Clin Microbiol Infect Human bocavirus (HBoV) was recently described as a new member of the Parvoviridae. In order to investigate the suggested association of HBoV with respiratory and gastric disease in infants and young children, sera of 357 paediatric patients hospitalized with infectious and non-infectious diseases were retrospectively analyzed for the presence of HBoV DNA and virus-specific antibodies using quantitative PCR and ELISA, respectively. HBoV seroprevalence was determined to range from 25% in infants younger than 1 year of age to 93% in children aged more than 3 years. Viral loads between 1 × 102 and 1.2 × 106 geq/mL were observed in 6.7% (20/297) of sera obtained preferentially from young children suffering from infectious diseases. HBoV genomes were furthermore detected ...

Human Bocavirus: A Cause of Severe Asthma Exacerbation in Children

The Journal of Pediatrics — Wed, 22 Jul 2009 11:28:22 +0100

Real-time polymerase chain reaction for human bocavirus (HBoV) was performed in nasopharyngeal aspirate specimens from 166 children over 2 years of age hospitalized for severe asthma exacerbation. Whereas HBoV was detected in 21 of these children (13%), it was found in only 1 of 50 ambulatory children with stable asthma (2%), suggesting a major role of HBoV in acute exacerbations in asthmatic children. (Source: The Journal of Pediatrics)

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[Media Watch] Books: The dictionary of virology

The Lancet Infectious Diseases — Sun, 19 Jul 2009 23:00:00 +0100

Recently we have witnessed an explosion in virus discovery. The highest profile of these “new” viruses is the severe acute respiratory syndrome coronavirus, which made its debut in 2001 with an alarming pandemic that infected 8000 people around the world and claimed 800 victims before it was brought under control. With new and rapid molecular techniques for virus discovery, and the recent development of mass sequencing, many new human and veterinary viruses have been discovered. These include several new polyomaviruses and picornaviruses, many of which might be pathogenic, and human bocavirus, which is implicated in childhood respiratory tract disease. (Source: The Lancet Infectious Diseases)

Detection of enteric viruses in rectal swabs from children with acute gastroenteritis attending the pediatric outpatient clinics in Sapporo, Japan

Journal of Clinical Virology — Wed, 15 Jul 2009 23:00:00 +0100

Conclusions: The prevalence of each enteric virus in outpatients resembled that previously estimated in hospitalized patients, although the detection rate of rotavirus was slightly low. The contribution of bocavirus appears to be small. (Source: Journal of Clinical Virology)

Prevalence of human bocavirus in human tonsils and adenoids.

Emerging Infectious Diseases — Tue, 30 Jun 2009 23:00:00 +0100

Authors: Clément N, Battaglioli G, Jensen RL, Schnepp BC, Johnson PR, St George K, Linden RM PMID: 19624951 [PubMed - in process] (Source: Emerging Infectious Diseases)

Detection of, and frequent co-infection with, human bocavirus in faecal specimens from children in Wuhan, China

Clinical Microbiology and Infection — Sun, 21 Jun 2009 23:00:00 +0100

Clin Microbiol Infect A novel parvovirus, human bocavirus (HBoV), was first discovered in children with respiratory tract infections in Sweden. A retrospective study of HBoV in faecal samples from children suffering from diarrhea, covering a 3-year period (November 2000 to October 2003) in Wuhan, China, was undertaken. PCR assays were used to evaluate 214 faecal samples and to determine the role of HBoV in diarrhoea. Among 196 virus-infected children with diarrhoea, 2.55% were HBoV-positive; however, all HBoV-positive patients were co-infected with common enteric viruses. This result does not support the notion that HBoV is a viral agent causing acute diarrhoea. (Source: Clinical Microbiology and Infection)

[Diagnosis and molecular epidemiology of viral gastroenteritis in the past, present and future]

Uirusu. Journal of Virology — Mon, 01 Jun 2009 00:00:00 +0100

Authors: Ushijima H Outline, history of research, diagnosis and molecular epidemiology of viral gastroenteritis were described. Rotavirus, adenovirus, norovirus, sapovirus, astrovirus, human parechovirus, Aichivirus, and human bocavirus are the major target viruses which cause acute gastroenteritis. The viruses were differentiated into genogroup, genotypes and subgenotypes/clusters/lineages. The changing of their genetic backgrounds was well recognized in different areas and years. Some reassortments or recombinations were observed not only between humans and humans but also between humans and animals. Viral gastroenteritis diseases were transmitted by food-borne and humans to humans contact. The environmental factors were also impacted on the infections. Recently, situation of the dis...

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No detection of human bocavirus in amniotic fluid samples from fetuses with hydrops or isolated effusions

Journal of Clinical Virology — Tue, 26 May 2009 23:00:00 +0100

Conclusion: We suggest that HBoV is not a common cause of fetal hydrops, anemia or isolated effusions. This has to be confirmed by further studies of proven gestational HBoV infection. (Source: Journal of Clinical Virology)

Detection of Human Bocavirus in bronchoalveolar lavage from Italian adult patients

Journal of Clinical Virology — Wed, 29 Apr 2009 16:48:39 +0100

In this study, no specimen resulted positive to HBoV and the authors concluded that this argued against a role for HBoV as a respiratory pathogen or co-pathogen in lung transplantation, as well as against a role as a bystander in the respiratory tract of adults. We have conducted a prospective study on HBoV prevalence in 341 consecutive BAL samples over an 18-month period. Bronchoalveolar lavage was performed for investigating the cause of unexplained fever and/or respiratory symptoms and/or new infiltrates on chest X-ray or as routine follow-up in lung transplant recipients at month 1 post-transplantation and subsequently at 3-month intervals. The presence of HBoV was evaluated by Real-Time TaqMan PCR, as previously described, following automated DNA extraction with the NucliSens easyMAG ...

Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections?

Journal of Clinical Virology — Wed, 29 Apr 2009 16:48:16 +0100

Conclusions: HRVs were proportionately under-represented among viral co-detections. For some period, HRVs may render the host less likely to be infected by other viruses. (Source: Journal of Clinical Virology)

[Respiratory infection] Respiratory viruses in bronchoalveolar lavage: a hospital-based cohort study in adults

Thorax — Tue, 28 Apr 2009 04:00:00 +0100

Conclusions: In this cohort of hospitalised adults, respiratory viruses detected in BAL fluid specimens were associated with respiratory symptoms, absence of radiological infiltrates and a poor response to antibiotic therapy. (Source: Thorax)

Detection of Human Bocavirus from Fecal Samples of Hungarian Children with Acute Gastroenteritis

Karger Publishers — Mon, 06 Apr 2009 15:24:56 +0100

Intervirology 2009;52:17-21 (DOI:10.1159/000210834) (Source: Karger Publishers)

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Phylogenetic analysis of human bocavirus (HBoV) detected from children with acute respiratory infection in Japan

Journal of Infection — Wed, 01 Apr 2009 04:00:00 +0100

In this study, in an attempt to clarify the epidemiology, we performed phylogenetic analysis of HBoV detected from Japanese children with ARI in recent years. (Source: Journal of Infection)

Detection of Human Bocavirus in bronchoalveolar lavage from Italian adult patients.

Journal of Clinical Virology — Tue, 24 Mar 2009 04:00:00 +0100

Authors: Costa C, Bergallo M, Cavallo R PMID: 19324589 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

Human bocavirus and KI/WU polyomaviruses in pediatric intensive care patients.

Emerging Infectious Diseases — Sat, 28 Feb 2009 14:35:00 +0100

Authors: van de Pol AC, Wolfs TF, Jansen NJ, Kimpen JL, van Loon AM, Rossen JW We evaluated the prevalence of human bocavirus and KI and WU polyomaviruses in pediatric intensive care patients with and without lower respiratory tract infection (LRTI). The prevalence of these viruses was 5.1%, 0%, and 2.6%, respectively, in children with LRTI and 4.8%, 4.8%, and 2.4%, respectively, in those without LRTI. PMID: 19239763 [PubMed - in process] (Source: Emerging Infectious Diseases)

[Paediatric lung disease] Induced sputum in the diagnosis of childhood community-acquired pneumonia

Thorax — Fri, 27 Feb 2009 05:00:00 +0100

Conclusions: Sputum induction provides good quality sputum specimens with high microbiological yield in children with community-acquired pneumonia. Induced sputum analysis can be useful in the microbiological diagnosis of childhood community-acquired pneumonia. (Source: Thorax)

Evidence of prior exposure to Human Bocavirus: a retrospective serological study of 404 adult sera in the United States.

Clinical and Vaccine Immunology — Wed, 25 Feb 2009 05:00:00 +0100

Authors: Cecchini S, Negrete A, Virag T, Graham B, Cohen JI, Kotin RM Recently, molecular screening for pathogenic agents has identified a partial genome of a novel parvovirus, called human bocavirus (HBoV). The presence of this newly described parvovirus correlated with upper and lower respiratory tract infections (LRTI) in children. LRTIs are a leading cause of hospital admission in children and the etiological agent has not been identified in up to 39% of these cases. Using baculovirus expression vectors (BEVs) and insect cell system; we produced virus-like-particles (VLP) of HBov. The engineered BEVs express the HBov capsid proteins stoichiometrically from a single open reading frame. Three capsid proteins assemble into the VLP rather than two proteins predicted from the HBoV genom...

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Clinical and microbiological impact of human bocavirus on children with acute otitis media

European Journal of Pediatrics — Tue, 17 Feb 2009 10:04:26 +0100

In conclusion, HBoV may worsen the clinical symptoms and prolong the clinical outcome of AOM in pediatric population. Finally, HBoV may prime the secondary bacterial infection in the middle ear in favor of S. pneumoniae. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00431-009-0939-7Authors Levent Bekir Beder, Wakayama Medical University Department of Otolaryngology-Head and Neck Surgery Kimiidera 811-1, Wakayama-shi 641-0012 Wakayama JapanMuneki Hotomi, Wakayama Medical University Department of Otolaryngology-Head and Neck Surgery Kimiidera 811-1, Wakayama-shi 641-0012 Wakayama JapanMasashi Ogami, Wakayama Medical University Department of Otolaryngology-Head and Neck Surgery Kimiidera 811-1, Wakayama-shi 641-0012 Wakayama JapanKazuma Yamauchi, Wakayama Medical Unive...

Healthcare-Associated Atypical Pneumonia

Seminars in Respiratory and Critical Care Medicine — Sun, 08 Feb 2009 20:11:30 +0100

This article discusses the history, epidemiology, and pathogenesis of infection; control of infection; clinical findings; diagnosis; and, where applicable, treatment of the agents of healthcare-associated atypical pneumonia. Bacterial agents include species, , species, and . Although there are over 100 viruses that can cause respiratory tract infections, only a fraction of those have been defined in the context of healthcare-associated atypical pneumonia: adenovirus and human bocavirus (HBoV); rhinovirus; human coronaviruses (HCoV), including HCoV 229E, HCoV OC43, HCoV NL63, HCoV HKU1; members of the paramyxoviridae (parainfluenza viruses, human metapneumovirus, and respiratory syncytial virus); hantavirus; influenza; and severe acute respiratory syndrome (SARS) Co-V. Our knowledge about h...

Clinical and genetic analysis of Human Bocavirus in children with lower respiratory tract infection in Taiwan.

Journal of Clinical Virology — Sat, 07 Feb 2009 05:00:00 +0100

CONCLUSION: HBoV may have circulated in Taiwan for some time and it appears to be one of the etiological agents responsible for lower respiratory tract infection in children. PMID: 19208496 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

Establishing a surveillance network for severe lower respiratory tract infections in Korean infants and young children

European Journal of Clinical Microbiology & Infectious Diseases — Wed, 04 Feb 2009 11:13:57 +0100

Abstract To reduce morbidity and mortality through integrated case management, a pilot study to detect respiratory viruses in patients with acute lower respiratory infections (ALRIs) was designed as part of a nationwide surveillance for this disease in Korea. The study population consisted of hospitalized patients under the age of 5 years with bronchiolitis, pneumonia, croup, or acute respiratory distress syndrome. A prospective 6-month study was performed. Two hundred and ninety-seven nasopharyngeal secretions were collected and multiplex reverse transcriptase polymerase chain reactions (RT-PCR)/polymerase chain reactions (PCR) were performed to detect respiratory viruses. If there were any positive RT-PCR/PCR results, viral cultures were proceeded for confirmation. ...

Human Bocavirus and KI/WU Polyomaviruses in Pediatric Intensive Care Patients, A.C. van de Pol et al.

Emerging Infectious Diseases Journal — Tue, 03 Feb 2009 18:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

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Detection of human bocavirus in hospitalised children

Journal of Paediatrics and Child Health — Tue, 03 Feb 2009 05:00:00 +0100

Conclusion: These results contribute to the interest in the HBoV detection in children. HBoV detection in hospitalised children with or without any other respiratory virus detection was essentially associated with lower respiratory tract infection and in a lower score with upper respiratory tract infection and gastroenteritis. (Source: Journal of Paediatrics and Child Health)

Human Metapneumovirus and Human Bocavirus in Children.

Pediatric Research — Wed, 28 Jan 2009 05:00:00 +0100

Authors: Milder E, Arnold JC Several new viruses have recently been described in children, including human metapneumovirus (hMPV) and human bocavirus (HBoV). hMPV has been established as a common cause of upper and lower respiratory tract infections in children, often second only to respiratory syncytial virus as a cause of bronchiolitis in infants. Diagnostic tools have been developed for the clinician and effective treatment and prevention strategies are being investigated. HBoV was more recently identified. Although it was initially identified in the airway of children, high rates of co-detection of other viral pathogens and detection of the virus in the stool have raised questions about the true role of human bocavirus as a cause of respiratory infections. A focus on epidemiology, ...

Humoral Immune Response Against Human Bocavirus VP2 Virus-Like Particles

Viral Immunology — Tue, 30 Dec 2008 17:28:22 +0100

Viral Immunology Dec 2008, Vol. 21, No. 4: 443-450. Human bocavirus (HBoV) was recently detected in samples from children and infants with infections of the respiratory tract. Here we analyze the prevalence of IgG and IgM antibodies against HBoV virus-like VP2 particles in healthy adult blood donors and ... (Source: Viral Immunology)

Comprehensive detection of causative pathogens using real-time PCR to diagnose pediatric community-acquired pneumonia

Journal of Infection and Chemotherapy — Wed, 17 Dec 2008 08:22:39 +0100

Abstract We have developed a real-time reverse transcription-PCR (RT-PCR) method to detect 13 respiratory viruses: influenza virus A and B; respiratory syncytial virus (RSV) subgroup A and B; parainfluenza virus (PIV) 1, 2, and 3; adenovirus; rhinovirus (RV); enterovirus; coronavirus (OC43); human metapneumovirus (hMPV); and human bocavirus (HBoV). The new method for detection of these viruses was applied simultaneously with real-time PCR for the detection of six bacterial pathogens in clinical samples from 1700 pediatric patients with community-acquired pneumonia (CAP). Of all the patients, 32.5% were suspected to have single bacterial infections; 1.9%, multiple bacterial infections; 15.2%, coinfections of bacteria and viruses; 25.8%, single viral infections; and 2.1%, mu...

Absence of human Bocavirus in bronchoalveolar lavage fluid of lung transplant patients.

Journal of Clinical Virology — Tue, 09 Dec 2008 05:00:00 +0100

Authors: Miyakis S, van Hal SJ, Barratt J, Stark D, Marriott D, Harkness J PMID: 19083266 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

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Comparison of four nasal sampling methods for the detection of viral pathogens by RT-PCR-A GA(2)LEN project.

Journal of Virological Methods — Tue, 25 Nov 2008 05:00:00 +0100

Authors: Spyridaki IS, Christodoulou I, de Beer L, Hovland V, Kurowski M, Olszewska-Ziober A, Carlsen KH, Lødrup-Carlsen K, van Drunen CM, Kowalski ML, Molenkamp R, Papadopoulos NG The aim of this study was to compare the efficacy and patient discomfort between four techniques for obtaining nasal secretions. Nasal secretions from 58 patients with symptoms of a common cold, from three clinical centers (Amsterdam, Lodz, Oslo), were obtained by four different methods: swab, aspirate, brush, and wash. In each patient all four sampling procedures were performed and patient discomfort was evaluated by a visual discomfort scale (scale 1-5) after each procedure. Single pathogen RT-PCRs for Rhinovirus (RV), Influenza virus and Adenovirus, and multiplex real-time PCR for RV, Enterovirus, In...

Human Bocavirus Is a Common, Asymptomatic Infection in Infants

Medscape Pediatrics Headlines — Fri, 07 Nov 2008 17:00:24 +0100

The recently discovered human bocavirus, a parvovirus found in the respiratory tracts of children with acute respiratory tract infections and in the feces of children with gastroenteritis, does not appear to be the cause of illness, Danish researchers report in the October issue of The Pediatric Infectious Disease Journal. Reuters Health Information (Source: Medscape Pediatrics Headlines)

Human bocavirus infection in children with acute gastroenteritis and healthy controls.

Japanese Journal of Infectious Diseases — Sat, 01 Nov 2008 04:00:00 +0100

Authors: Chieochansin T, Thongmee C, Vimolket L, Theamboonlers A, Poovorawan Y Human bocavirus (HBoV) is a novel virus which can cause respiratory tract disease in infants and children. Recently, the prevalence of this virus was studied worldwide not only in the respiratory tract, but also in the gastrointestinal tract. The results of this study focusing on the HBoV detection in stool samples showed that HBoV could only be found in the stool of children with acute gastroenteritis (0.9%), not in the healthy control samples. Moreover, the complete coding sequences of these HBoV also showed very conserved sequences. PMID: 19050360 [PubMed - in process] (Source: Japanese Journal of Infectious Diseases)

Human Bocavirus Infection in Children With Respiratory Tract Disease.

The Pediatric Infectious Disease Journal — Tue, 28 Oct 2008 10:35:27 +0100

Page: 969DOI: 10.1097/INF.0b013e31817acfaaAuthors: Brieu, Nathalie MSc *; Guyon, Gael MD +; Rodiere, Michel MD +; Segondy, Michel PhD *; Foulongne, Vincent PhD * (Source: The Pediatric Infectious Disease Journal)

Role of Human Bocavirus infections in outbreaks of gastroenteritis.

Journal of Clinical Virology — Wed, 01 Oct 2008 04:00:00 +0100

CONCLUSIONS: This study indicates that HBoV is not a causative agent for gastroenteritis outbreaks. PMID: 18835213 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

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Bocavirus infections in children

Future Medicine: Pediatric Health — Mon, 29 Sep 2008 14:08:07 +0100

Pediatric Health , October 2008, Vol. 2, No. 5, Pages 549-551. (Source: Future Medicine: Pediatric Health)

Clinical and Epidemiologic Characteristics of Human Bocavirus in Danish Infants: Results From a Prospective Birth Cohort Study.

The Pediatric Infectious Disease Journal — Sat, 27 Sep 2008 11:08:27 +0100

Page: 897DOI: 10.1097/INF.0b013e3181757b16Authors: von Linstow, Marie-Louise MD, PhD *; Hogh, Mette MSc, PhD +; Hogh, Birthe MD, DMSc * (Source: The Pediatric Infectious Disease Journal)

Clinical and epidemiological aspects of human bocavirus infection.

Journal of Clinical Virology — Thu, 25 Sep 2008 04:00:00 +0100

Authors: Lindner J, Karalar L, Schimanski S, Pfister H, Struff W, Modrow S Human bocavirus was recently described as a novel member of the Parvoviridae to infect humans. Based on accumulating clinical and epidemiological data the virus is currently being associated with respiratory infections in young children and infants and is furthermore discussed as causative agent of gastrointestinal illness. PMID: 18823816 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

Evidence of human bocavirus circulating in children and adults, Cleveland, Ohio.

Journal of Clinical Virology — Thu, 18 Sep 2008 04:00:00 +0100

CONCLUSIONS: HBoV circulates in Cleveland, OH, in children and adults with similar frequencies, and can warrant hospitalization and intensive care. Further study would clarify our understanding of this newly recognized human pathogen. PMID: 18805051 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

The challenge of respiratory virus infections in hematopoietic cell transplant recipients

British Journal of Haematology — Fri, 12 Sep 2008 04:00:00 +0100

This article reviews the spectrum of pathogens, epidemiology, risk factors and clinical manifestations of infection, as well as recent advances in diagnostic and clinical management. (Source: British Journal of Haematology)

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Human bocavirus in children suffering from acute lower respiratory tract infection in Beijing Children's Hospital.

Chinese Medical Journal — Fri, 05 Sep 2008 04:00:00 +0100

CONCLUSIONS: HBoV was detected in about 5% of children with acute lower respiratory infection seen in Beijing Children's Hospital. Further investigations regarding clinical and epidemiologic characteristics of HBoV infection are needed. PMID: 19024084 [PubMed - in process] (Source: Chinese Medical Journal)

Bocavirus infection in children: what should be the next to do?

Chinese Medical Journal — Fri, 05 Sep 2008 04:00:00 +0100

Authors: Zhaori GT PMID: 19024083 [PubMed - in process] (Source: Chinese Medical Journal)

No gastroenteric Bocavirus in high risk patients stool samples.

Journal of Clinical Virology — Tue, 26 Aug 2008 04:00:00 +0100

Authors: Ziegler S, Tillmann RL, Müller A, Simon A, Schildgen V, Schildgen O PMID: 18755626 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

[Reviews] The treatment of bronchiolitis

Archives of Disease in Childhood — Thu, 21 Aug 2008 04:00:00 +0100

This article summarises the current understanding of the different bronchiolitis phenotypes, with a brief description of outcomes and a review of the evidence for the various therapeutic interventions. (Source: Archives of Disease in Childhood)

Human bocavirus in tonsillar lymphocytes.

Emerging Infectious Diseases — Fri, 01 Aug 2008 04:00:00 +0100

Authors: Lu X, Gooding LR, Erdman DD To the Editor: We read with great interest the recent report by Longtin and colleagues describing human bocavirus (HBoV) infection among Canadian children with acute respiratory tract illnesses (ARI). The authors identified HBoV by PCR in nasopharyngeal aspirates from 13.8% of young children hospitalized with ARI, an infection rate well within the range reported by other studies on children. However, these authors also detected an unexpectedly high rate of HBoV for their control group (43%), >3 times the rate for ARI case-patients. In contrast, several similar studies did not detect HBoV in asymptomatic children. Kesebir et al. detected HBoV in 23 (5.2%) of 425 young children with ARI but in none of 96 children during routine well-child visits. M...

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Clinical Characteristics of Human Bocavirus Infections Compared With Other Respiratory Viruses in Spanish Children.

The Pediatric Infectious Disease Journal — Mon, 28 Jul 2008 23:46:28 +0100

Page: 677DOI: 10.1097/INF.0b013e31816be052Authors: Calvo, Cristina PhD *; Garcia-Garcia, Maria Luz MD *; Pozo, Francisco PhD +; Carvajal, Olga MD *; Perez-Brena, Pilar PhD +; Casas, Inmaculada PhD + (Source: The Pediatric Infectious Disease Journal)

Th1 and Th2 cytokine levels in nasopharyngeal aspirates from children with human bocavirus bronchiolitis.

Journal of Clinical Virology — Mon, 21 Jul 2008 04:00:00 +0100

CONCLUSIONS: These results showed that both of Th1 and Th2 cytokines were increased in children with hBoV-related bronchiolitis compared to normal controls, but Th2-polarized responses were not observed. PMID: 18650126 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

Human Bocavirus quantitative DNA detection in French children hospitalized for acute bronchiolitis.

Journal of Clinical Virology — Sat, 19 Jul 2008 04:00:00 +0100

CONCLUSIONS: Our data suggest that HBoV at a high viral load could be an etiologic agent of respiratory tract disease, whereas the exact role of HBoV at a low viral load, as etiological cause or as pathophysiological co-factor of respiratory diseases, remains to be determined. PMID: 18644746 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

Human Bocavirus in Tonsillar Lymphocytes, X. Lu et al.

Emerging Infectious Diseases Journal — Tue, 24 Jun 2008 19:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

Human Bocavirus -- A Novel Parvovirus to Infect Humans

Intervirology — Fri, 06 Jun 2008 15:39:42 +0100

Intervirology 2008;51:116-122 (DOI:10.1159/000137411) (Source: Intervirology)

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Human rhinoviruses: The cold wars resume.

Journal of Clinical Virology — Fri, 23 May 2008 04:00:00 +0100

CONCLUSION: The finding of many divergent and previously unrecognized HRV strains has drawn attention and resources back to the most widespread and frequent infectious agent of humans; providing us the chance to seize the advantage in a decades-long cold war. PMID: 18502684 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

Human bocavirus infection in children hospitalized with acute gastroenteritis in China.

Journal of Clinical Virology — Tue, 20 May 2008 04:00:00 +0100

CONCLUSIONS: Despite its high infection rate, there was no statistically significant a causual relationship between HBoV and gastroenteritis in children. PMID: 18499516 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

Emerging respiratory agents: New viruses for old diseases?

Journal of Clinical Virology — Thu, 10 Apr 2008 04:00:00 +0100

Authors: Sloots TP, Whiley DM, Lambert SB, Nissen MD The recent advances in molecular technology have enabled the detection of several new viral agents in specimens collected from the human respiratory tract. Human metapneumovirus was first described in 2001, and is a significant respiratory pathogen, particularly of children. Following the identification of severe acute respiratory syndrome (SARS) associated coronavirus, two other newly detected coronaviruses, NL63 and HKU1, have been linked to respiratory disease in humans. However, identifying a new virus as the causative agent of a specific disease is difficult, and ideally would involve satisfying Koch's postulates. The recently described human bocavirus and polyomaviruses KI and WU have been detected in samples collected from hum...

Human bocavirus detection in nasopharyngeal aspirates of children without clinical symptoms of respiratory infection.

The Pediatric Infectious Disease Journal — Tue, 01 Apr 2008 13:01:05 +0100

Page: 358DOI: 10.1097/INF.0b013e3181626d2aAuthors: Garcia-Garcia, Maria Luz MD *; Calvo, Cristina PhD *; Pozo, Francisco PhD +; Perez-Brena, Pilar PhD +; Quevedo, Sergio MD *; Bracamonte, Teresa MD *; Casas, Inmaculada PhD + (Source: The Pediatric Infectious Disease Journal)

Human bocavirus: passenger or pathogen in acute respiratory tract infections?

Clinical Microbiology Reviews — Tue, 01 Apr 2008 04:00:00 +0100

We present a model incorporating these somewhat contradictory findings and suggest that primary HBoV infection causes respiratory tract symptoms which can be followed by prolonged low-level virus shedding in the respiratory tract. Detection of the virus in this phase will be facilitated by other infections, either simply via increased sample cell count or via reactivation of HBoV, leading to an increased detection frequency of HBoV during other virus infections. We conclude that the majority of available HBoV studies are limited by the sole use of PCR diagnostics on respiratory tract secretions, addressing virus prevalence but not disease association. The ability to detect primary infection through the development of improved diagnostic methods will be of great importance for future studie...

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Development of real-time PCR assays for detection and quantification of human bocavirus.

Journal of Clinical Virology — Sat, 29 Mar 2008 04:00:00 +0100

CONCLUSIONS: The three assays for HBoV diagnosis and quantification are highly sensitive, specific real-time tools for the reliable epidemiological and pathogenetic study of HBoV infection. PMID: 18378492 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

Undiagnosed Respiratory Viruses in Children

PEDIATRICS — Fri, 29 Feb 2008 05:00:00 +0100

CONCLUSIONS. Adenoviruses, human bocavirus, and human metapneumovirus were each present in ~5% of specimens submitted for respiratory virus rapid testing. The lower respiratory tract was more commonly affected in patients with human bocavirus and human metapneumovirus infections. Adenovirus was often undiagnosed by antigen detection. Other findings included the presence of a pertussis-like illness associated with human bocavirus. (Source: PEDIATRICS)

Pediatric hospitalization of acute respiratory tract infections with Human Bocavirus in Hong Kong.

Journal of Clinical Virology — Fri, 22 Feb 2008 05:00:00 +0100

CONCLUSIONS: HBoV plays an important role in hospitalized children </=3 years with upper and lower respiratory tract infections in Hong Kong. PMID: 18296108 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

ELISAs using human bocavirus VP2 virus-like particles for detection of antibodies against HBoV.

Journal of Virological Methods — Mon, 18 Feb 2008 05:00:00 +0100

Authors: Lin F, Guan W, Cheng F, Yang N, Pintel D, Qiu J Human bocavirus (HBoV) has been identified worldwide in children with lower respiratory tract infections with an incidence of approximately 2-11%. The role of HBoV in pathogenesis, however, is largely unknown, and little is known about the epidemiology of the virus. To study the seroepidemiology of HBoV infection, the capsid protein was expressed in insect cells. Expression of the putative major capsid protein VP2 in insect cells led to the formation of virus-like particles exhibiting the typical icosahedral appearance of parvoviruses with a diameter of approximately 20nm. The expressed particles were used to establish an enzyme-linked immunosorbent assay (ELISA) method, and serum samples from groups of children of various ages i...

Human bocavirus: clinical significance and implications.

Current Opinion in Pediatrics — Wed, 16 Jan 2008 09:35:35 +0100

Page: 62DOI: 10.1097/MOP.0b013e3282f3f518Authors: Kahn, Jeffrey (Source: Current Opinion in Pediatrics)

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Human Bocavirus Infections in Hospitalized Children and Adults, J. Longtin et al.

Emerging Infectious Diseases Journal — Thu, 03 Jan 2008 15:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

Human bocavirus in greek children with respiratory tract infection

PEDIATRICS — Wed, 02 Jan 2008 05:00:00 +0100

CONCLUSIONS: This is the first report of human bocavirus infection in Greece, which suggests that the virus is spread worldwide, and it is associated with RTI in infants and young children. (Source: PEDIATRICS)

Children with persistent wheezing associated with human bocavirus infection in china

PEDIATRICS — Wed, 02 Jan 2008 05:00:00 +0100

CONCLUSIONS: This study confirmed that HBoV is a common pathogen for children with lower respiratory infection and might particularly be attributed to persistent wheezing. However, more studies should be performed to study the mechanism of HBoV on chronic airway inflammation. (Source: PEDIATRICS)

Detection of human bocavirus in chinese children with respiratory tract infection

PEDIATRICS — Wed, 02 Jan 2008 05:00:00 +0100

CONCLUSIONS: HBoV seems to be one of the respiratory pathogens for acute respiratory tract infection in the Chongqing area, particularly in young children. Understanding of the clinical relevance of HBoV infection will require additional studies. (Source: PEDIATRICS)

Genotyping of human bocavirus using a restriction length polymorphism

Virus Genes — Tue, 11 Dec 2007 15:36:19 +0100

Abstract Sequencing analysis of the isolates of a recently identified pathogen associated with respiratory infections, human bocavirus (HBoV), allowed for identification of two virus genotypes of the virus. In the current article a new method for a simple and fast differentiation of HBoV genotypes in clinical materials is described. The test includes an amplification of a 309 bp fragment of VP1/VP2 gene of HBoV from nasopharyngeal aspirates with a subsequent incubation of a PCR mix with the BstAPI endonuclease. Upon such a digestion, the DNA fragment derived from the genotype I HBoV isolates forms two fragments of 150 and 159 bp, while that obtained from genotype 2 isolates remains unrestricted. The developed technique may be used in epidemiological studies of HB...

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Human bocavirus commonly involved in multiple viral airway infections.

Journal of Clinical Virology — Fri, 07 Dec 2007 05:00:00 +0100

CONCLUSIONS: HBoV was frequently detected in nasopharyngeal aspirates from children with airway infections in Norway. Multiple viral infections were common among the HBoV-infected patients. Semiquantitive PCR results may be useful for interpretation of clinical relevance. PMID: 18069054 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

Human bocavirus.

Journal of Clinical Virology — Tue, 04 Dec 2007 05:00:00 +0100

Authors: Allander T Human bocavirus (HBoV) was first described in 2005 in nasopharyngeal aspirates of children with respiratory tract infection. Multiple studies have confirmed the presence of HBoV in respiratory tract samples of children world-wide. HBoV has recently also been detected in blood and fecal samples. Most studies so far have studied virus prevalence, and only a few reports provide data regarding the linkage of HBoV to disease. These reports indicate that HBoV infection is indeed associated with acute respiratory tract symptoms, but also that HBoV may persist in the respiratory tract for a longer time than other respiratory agents, resulting in frequent detection of low load HBoV carriage. This phenomenon has complicated the use of PCR diagnostics, which has been the only ...

Detection of human bocavirus in Asturias, Northern Spain

European Journal of Clinical Microbiology & Infectious Diseases — Sun, 25 Nov 2007 19:08:20 +0100

Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s10096-007-0419-9Authors L. Villa, Hospital Universitario Central de Asturias Sección de Virología (Servicio de Microbiología) Celestino Villamil s/n 33006 Oviedo SpainS. Melón, Hospital Universitario Central de Asturias Sección de Virología (Servicio de Microbiología) Celestino Villamil s/n 33006 Oviedo SpainS. Suárez, Hospital Universitario Central de Asturias Pediatric Service Oviedo SpainM. E. Alvarez-Argüelles, Hospital Universitario Central de Asturias Sección de Virología (Servicio de Microbiología) Celestino Villamil s/n 33006 Oviedo SpainD. Gónzalez, Hospital Universitario Central de Asturias Sección de Virología (Servicio de Microbiología) Celestino Villamil s/n 33006 Oviedo SpainA. Morilla, Hospital...

Human bocavirus in children with acute lymphoblastic leukemia

European Journal of Pediatrics — Sun, 25 Nov 2007 19:08:18 +0100

We report three children with acute lymphoblastic leukemia who had acute febrile episodes with concomitant detection of human bocavirus in their respiratory secretions. One of them had five consecutive febrile episodes during 6 months, all associated with the presence of human bocavirus at varying viral loads, suggesting prolonged shedding or reactivation of the virus. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00431-007-0631-8Authors Minna Koskenvuo, Turku University Hospital Department of Pediatrics Kiinamyllynkatu 4-8 FI-20520 Turku FinlandMerja Möttönen, Oulu University Department of Pediatrics Oulu FinlandMatti Waris, Turku University Department of Virology Turku FinlandTobias Allander, Karolinska University Hospital Department of Clinical Microbiology S...

No evidence for an association between infections with WU and KI polyomaviruses and respiratory disease.

Journal of Clinical Virology — Tue, 06 Nov 2007 05:00:00 +0100

CONCLUSIONS: WUV and KIPyV were detected in 10 and 14 samples, respectively from 983 specimens (from 9 to 10 different individuals from 612 study subjects). Infections occurred in two types of study subject; those who were young (<2 years) with lower respiratory tract infections (n=8), and almost invariably co-infected with other respiratory viruses (RSV, AdV), and a second, generally older group either without respiratory disease (n=6) or with mild upper respiratory tract infections (n=5) but who were generally clinically severely immunosuppressed from leukaemia or transplant therapy. Findings from either group do not support an aetiological link between infection with WUV or KIPyV and respiratory disease. PMID: 17997354 [PubMed - as supplied by publisher] (Source: Journal of Clini...

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Phospholipase A(2)-like activity of human bocavirus VP1 unique region.

Biochemical and Biophysical Research communications — Thu, 01 Nov 2007 04:00:00 +0100

Authors: Qu XW, Liu WP, Qi ZY, Duan ZJ, Zheng LS, Kuang ZZ, Zhang WJ, Hou YD Human bocavirus (HBoV) is a new parvovirus first discovered in 2005, which is associated with acute respiratory infection. Analysis of sequence homology has revealed that a putative phospholipase A(2) (PLA(2)) motif exists in the VP1 unique region of HBoV. However, little is known about whether the VP1 unique region of HBoV has PLA(2) enzymatic activity and how these critical residues contribute to its PLA(2) activity. To address these issues, the VP1 unique region protein and four of its mutants, were expressed in Eschericha coli. The purified VP1 unique protein (VP1U) showed a typical Ca(2+)-dependent secreted PLA(2)-like (sPLA(2)) activity, which was inhibited by sPLA(2)-specific inhibitors in a time-depend...

Human bocavirus in infants, New Zealand.

Emerging Infectious Diseases — Thu, 01 Nov 2007 04:00:00 +0100

Authors: Redshaw N, Wood C, Rich F, Grimwood K, Kirman JR PMID: 18217577 [PubMed - in process] (Source: Emerging Infectious Diseases)

Human bocavirus infection in children with gastroenteritis, Brazil.

Emerging Infectious Diseases — Thu, 01 Nov 2007 04:00:00 +0100

Authors: Albuquerque MC, Rocha LN, Benati FJ, Soares CC, Maranhão AG, Ramírez ML, Erdman D, Santos N Human bocavirus (HBoV) was detected in 14 (2%) of 705 fecal specimens from Brazilian children with gastroenteritis. Coinfection with rotavirus, adenovirus, or norovirus was found in 3 (21.4%) HBoV-positive specimens. None of the HBoV-positive patients had respiratory symptoms. PMID: 18217564 [PubMed - in process] (Source: Emerging Infectious Diseases)

Human Bocavirus in Infants, New Zealand, N. Redshaw et al.

Emerging Infectious Diseases Journal — Mon, 22 Oct 2007 19:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

Human Bocavirus Infection in Children with Gastroenteritis, Brazil, M.C.M. Albuquerque et al.

Emerging Infectious Diseases Journal — Fri, 28 Sep 2007 21:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

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Human bocavirus infection in hospitalized children during winter.

The Pediatric Infectious Disease Journal — Fri, 28 Sep 2007 00:24:27 +0100

Page: 959DOI: 10.1097/INF.0b013e3181256583Authors: Catalano-Pons, Charlotte MD *; Bue, Melanie MD *; Laude, Helene MD +; Cattan, Florence MD +; Moulin, Florence MD *; Menager, Cedric MD *; Cosnes-Lambe, Cecile MD *; Chalumeau, Martin PhD *; Giraud, Carole MD +; Meritet, Jean-Francois MD +; Rozenberg, Flore PhD +; Lebon, Pierre PhD +; Gendrel, Dominique MD * (Source: The Pediatric Infectious Disease Journal)

High incidence of human bocavirus infection in children in Spain.

Journal of Clinical Virology — Wed, 26 Sep 2007 04:00:00 +0100

CONCLUSIONS: Results obtained provide further evidence that HBoV is involved in acute lower respiratory tract infections. HBoV-associated disease should not be limited to the respiratory tract. PMID: 17904416 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

Human Bocavirus and Gastroenteritis (response), O. Schildgen et al.

Emerging Infectious Diseases Journal — Mon, 17 Sep 2007 19:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

Detection of human bocavirus in children with Kawasaki disease

Clinical Microbiology and Infection — Tue, 11 Sep 2007 03:36:01 +0100

Clinical Microbiology and Infection Volume 0, Issue 0, Page ???-???. AbstractHuman bocavirus (HboV) is an emerging virus that has been implicated as a cause of acute upper and lower respiratory tract infection in children. As no serological assay is available, PCR was used to screen nasopharyngeal, serum or stool samples fr... (Source: Clinical Microbiology and Infection)

Prospective study of Human Bocavirus (HBoV) infection in a pediatric university hospital in Germany 2005/2006.

Journal of Clinical Virology — Mon, 10 Sep 2007 04:00:00 +0100

CONCLUSION: HBoV causes severe respiratory tract infections in infants and young children. Its role as a copathogen and many other open questions has to be defined in further prospective studies. PMID: 17851126 [PubMed - as supplied by publisher] (Source: Journal of Clinical Virology)

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Human bocavirus detection in an atopic child affected by pneumonia associated with wheezing.

Journal of Clinical Virology — Sat, 01 Sep 2007 04:00:00 +0100

CONCLUSIONS: Detection of HboV, as the only microbial agent, in samples from children with wheezing and acute respiratory diseases supports the assumption that this emerging virus could have an aetiologic role in the pathogenesis of respiratory diseases. PMID: 17686654 [PubMed - in process] (Source: Journal of Clinical Virology)

[Human bocavirus infections in Spanish 0-14 year-old: clinical and epidemiological characteristics of an emerging respiratory virus]

Anales de Pediatria — Sat, 01 Sep 2007 04:00:00 +0100

CONCLUSIONS: HBoV is one of the most frequent viruses in severe respiratory infections in patients aged less than 14 years old. Only RSV and rhinovirus are more frequent. Coinfections are highly frequent. Most patients are infants with recurrent wheezing and bronchiolitis. PMID: 17785157 [PubMed - indexed for MEDLINE] (Source: Anales de Pediatria)

Clinical and Molecular Epidemiology of Human Bocavirus in Respiratory and Fecal Samples from Children in Hong Kong

The Journal of Infectious Diseases Latest Articles — Wed, 29 Aug 2007 05:00:00 +0100

Background. Human bocavirus (HBoV) is a recently discovered parvovirus associated with respiratory tract infections in children. We conducted the first systematic prospective clinical and molecular study using nasopharyngeal aspirates (NPAs) and fecal samples.Methods. NPAs negative for influenza virus, parainfluenza virus, respiratory syncytial virus, adenovirus, and coronavirus and fecal samples from patients with acute gastroenteritis were included. On the basis of results from a pilot study using 400 NPAs from all age groups, a prospective 12-month study was conducted to detect HBoV in 1200 NPAs and 1435 fecal samples from patients (Source: The Journal of Infectious Diseases Latest Articles)

Human Bocavirus: Multisystem Detection Raises Questions about Infection

The Journal of Infectious Diseases Latest Articles — Wed, 29 Aug 2007 05:00:00 +0100

(Source: The Journal of Infectious Diseases Latest Articles)

Detection of Human Bocavirus in Children Hospitalized because of Acute Gastroenteritis

The Journal of Infectious Diseases Latest Articles — Thu, 23 Aug 2007 05:00:00 +0100

The idea that human bocavirus (hBoV) infection possibly plays a role in gastroenteritis has been suggested because of the frequent manifestation of gastrointestinal symptoms. The purpose of this study was to investigate the prevalence of hBoV in children with gastroenteritis. We studied the etiologic agents in 962 children hospitalized with gastroenteritis. Viral etiologic agents were detected by enzyme-linked immunosorbent assay or reverse–transcriptase polymerase chain reaction. A viral agent was found in 44.4% of the study population: rotavirus, norovirus, adenovirus, and astrovirus were detected in 25.7%, 13.7%, 3.0%, and 1.1% of the study population, respectively; hBoV was detected in 0.8%, which suggests that it might play a minor role in gastroenteritis. (Source: The Journal of In...

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Infections with the novel human bocavirus.

Reviews in Medical Microbiology — Wed, 15 Aug 2007 00:55:22 +0100

Page: 5DOI: 10.1097/MRM.0b013e3282e1c680Authors: Naghipour, Mohammadreza a,b,c; Hart, C Anthony a; Cuevas, Luis E a,c (Source: Reviews in Medical Microbiology)

Disseminated Bocavirus Infection after Stem Cell Transplant, T. Schenk et al.

Emerging Infectious Diseases Journal — Thu, 02 Aug 2007 20:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

Volume 45, number 3: Human Bocavirus in Children with Acute Asthma

Clinical Infectious Diseases Latest Issue — Thu, 28 Jun 2007 18:00:24 +0100

(Source: Clinical Infectious Diseases Latest Issue)

Complete coding sequences and phylogenetic analysis of Human Bocavirus (HBoV).

Virus Research — Fri, 25 May 2007 04:00:00 +0100

In this study, 18 of 252 (7.14%) nasopharyngeal suctions from infants or children between 1 month and 9 years of age with respiratory tract illness were HBoV-positive by PCR. Three positive samples were selected for sequencing the entire coding sequences using a new conserved set of primers. The results showed that the most conserved regions of HBoV are the NS1 and NP1 genes, whereas VP1 and VP2 showed frequent variations. However, the complete coding sequences showed that the variations did not depend on the origin of virus found. The complete coding sequences determined in this study can resolve the problem of an HBoV detection method, which can be advantageously implemented in laboratory detection. PMID: 17532505 [PubMed - as supplied by publisher] (Source: Virus Research)

Volume 195, number 9: Comparison of Tissue Distribution, Persistence, and Molecular Epidemiology of Parvovirus B19 and Novel Human Parvoviruses PARV4 and Human Bocavirus

The Journal of Infectious Diseases Latest Issue — Mon, 02 Apr 2007 18:02:52 +0100

Background. PARV4 and human bocavirus (HBoV) are newly discovered human parvoviruses with poorly understood epidemiologies and disease associations. We investigated the frequencies of persistence, tissue distribution, and influence of immunosuppression on replication of these viruses.Methods. At autopsy, bone marrow, lymphoid tissue, and brain tissue from human immunodeficiency virus (HIV)–infected individuals with acquired immunodeficiency syndrome (AIDS) and those without AIDS and from HIV-uninfected individuals were screened for parvovirus B19, PARV4, and HBoV DNA by means of quantitative polymerase chain reaction analyses.Results. B19 DNA was detected both in HIV-infected study subjects (13 of 24) and in HIV-uninfected study subjects (8 of 8), whereas PARV4 DNA was detected only in H...

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Human bocavirus in Italian patients with respiratory diseases.

Journal of Clinical Virology — Sun, 01 Apr 2007 04:00:00 +0100

CONCLUSIONS: The findings indicate that hBoV can cause ARD in infants. PMID: 17336143 [PubMed - in process] (Source: Journal of Clinical Virology)

Comparison of Tissue Distribution, Persistence, and Molecular Epidemiology of Parvovirus B19 and Novel Human Parvoviruses PARV4 and Human Bocavirus

The Journal of Infectious Diseases Latest Articles — Wed, 21 Mar 2007 05:00:00 +0100

Volume 195, number 7: Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand

The Journal of Infectious Diseases Latest Issue — Fri, 02 Mar 2007 19:42:47 +0100

We examined outpatients with influenza-like illness for HBoV infection and tested for 13 additional respiratory viruses. Epidemiologic and clinical characteristics of HBoV infection are described.Results. HBoV infection was detected in 20 (3.9%) of 512 outpatients and 3 (1%) of 280 control patients. Coinfection with other viruses was detected in 83% of patients with pneumonia and in 90% of outpatients. Compared with control patients, HBoV infection was significantly associated with pneumonia requiring hospitalization (adjusted odds ratio, 3.56 [95% confidence interval, 1.06–11.91]; [FORMULA]). Eighty-three percent of HBoV infections were detected in patients with pneumonia who were (Source: The Journal of Infectious Diseases Latest Issue)

Human Bocavirus, a Respiratory and Enteric Virus, D. Vicente et al.

Emerging Infectious Diseases Journal — Mon, 26 Feb 2007 16:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand

The Journal of Infectious Diseases Latest Articles — Fri, 16 Feb 2007 06:00:00 +0100

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Human Bocavirus and Acute Wheezing in Children

Clin Infect Dis Latest Articles — Wed, 14 Feb 2007 06:00:00 +0100

Conclusions. Human bocavirus is prevalent among children with acute wheezing and can cause systemic infection. Results suggest a model for bocavirus infection in which high viral loads are potentially associated with respiratory symptoms and low viral loads indicate asymptomatic shedding. Therefore, quantitative polymerase chain reaction analysis may be important for additional studies of human bocavirus. (Source: Clin Infect Dis Latest Articles)

Human Bocavirus: A New Viral Pathogen

Clin Infect Dis Latest Articles — Wed, 14 Feb 2007 06:00:00 +0100

(Source: Clin Infect Dis Latest Articles)

Isolation of human bocavirus from swiss infants with respiratory infections.

The Pediatric Infectious Disease Journal — Mon, 05 Feb 2007 15:01:02 +0100

(Source: The Pediatric Infectious Disease Journal)

Quantification of human bocavirus in lower respiratory tract infections in China

Infectious Agents and Cancer — Wed, 31 Jan 2007 07:00:00 +0100

A quantitative PCR method was established to quantify human bocavirus (HBoV) genomic copies in clinical specimens from children with lower respiratory tract infections (LRTI) in China. A total of 257 respiratory tract specimens were tested, and 7 (2.7%) of these (all sputum samples) were positive, with genomic copies that ranged from 8.0 x 10 3 to 8.0 x 10 9 in the samples. The main clinical symptom of patients who were positive for HBoV DNA was a pneumonia-like syndrome represented by high fever and cough. Our results suggest that HBoV may be an important etiological agent of LRTI in children in China. (Source: Infectious Agents and Cancer)

Volume 195, number 5: Spectrum of Viruses and Atypical Bacteria in Intercontinental Air Travelers with Symptoms of Acute Respiratory Infection

The Journal of Infectious Diseases Latest Issue — Tue, 30 Jan 2007 22:43:22 +0100

Respiratory infections after air travel are frequent, but epidemiological data are incomplete. Using sensitive polymerase chain reactions, we studied the spectrum of atypical bacteria and respiratory viruses in travelers fulfilling the case definition of severe acute respiratory syndrome. A pathogen was identified in 67 travelers (43.2%). Influenza and parainfluenza viruses were most prevalent, at 14.2% and 15.5%, respectively. Prevalences of adenoviruses, human metapneumovirus, coronaviruses, and rhinoviruses ranged between 2.6% and 4.8%. Human bocavirus, respiratory syncytial virus, and Legionella, Mycoplasma, and Chlamydophila species were absent or appeared at frequencies of (Source: The Journal of Infectious Diseases Latest Issue)

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Spectrum of Viruses and Atypical Bacteria in Intercontinental Air Travelers with Symptoms of Acute Respiratory Infection

The Journal of Infectious Diseases Latest Articles — Thu, 18 Jan 2007 06:00:00 +0100

Human bocavirus DNA detected by quantitative real-time PCR in two children hospitalized for lower respiratory tract infection

European Journal of Clinical Microbiology & Infectious Diseases — Thu, 11 Jan 2007 07:48:41 +0100

Content TypeJournal Article JournalEuropean Journal of Clinical Microbiology & Infectious DiseasesOnline ISSN 1435-4373Print ISSN 0934-9723 (Source: European Journal of Clinical Microbiology & Infectious Diseases)

Human bocavirus in febrile children, The Netherlands.

Emerging Infectious Diseases — Mon, 01 Jan 2007 05:00:00 +0100

Authors: Monteny M, Niesters HG, Moll HA, Berger MY PMID: 17370546 [PubMed - in process] (Source: Emerging Infectious Diseases)

Human bocavirus infection, People's Republic of China.

Emerging Infectious Diseases — Mon, 01 Jan 2007 05:00:00 +0100

Authors: Qu XW, Duan ZJ, Qi ZY, Xie ZP, Gao HC, Liu WP, Huang CP, Peng FW, Zheng LS, Hou YD A newly identified parvovirus, human bocavirus (HBoV), was found in 21 (8.3%) of 252 nasopharyngeal aspirates from hospitalized children with lower respiratory tract infection in Hunan Province, People's Republic of China. Viral loads were 10(4) to 10(10) copies/mL. Phylogenetic analysis of the VP1 gene showed a single genetic lineage of HBoV worldwide. PMID: 17370538 [PubMed - in process] (Source: Emerging Infectious Diseases)

Severe pneumonia and human bocavirus in adult.

Emerging Infectious Diseases — Sat, 23 Dec 2006 02:19:02 +0100

Authors: Kupfer B, Vehreschild J, Cornely O, Kaiser R, Plum G, Viazov S, Franzen C, Tillmann RL, Simon A, Müller A, Schildgen O PMID: 17176591 [PubMed - in process] (Source: Emerging Infectious Diseases)

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Human Bocavirus Infection, People's Republic of China, X.-W. Qu et al.

Emerging Infectious Diseases Journal — Tue, 19 Dec 2006 14:25:00 +0100

(Source: Emerging Infectious Diseases Journal)

Human Bocavirus in Febrile Children, the Netherlands, M. Monteny et al.

Emerging Infectious Diseases Journal — Fri, 15 Dec 2006 14:35:00 +0100

(Source: Emerging Infectious Diseases Journal)

Prevalence of viral respiratory tract infections in children with asthma.

Journal of Allergy and Clinical Immunology — Tue, 05 Dec 2006 19:24:01 +0100

CONCLUSION: Symptomatic rhinovirus infections are an important contributor to asthma exacerbations in children. CLINICAL IMPLICATIONS: These results support the need for therapies effective against rhinovirus as a means to decrease asthma exacerbations. PMID: 17140648 [PubMed - as supplied by publisher] (Source: Journal of Allergy and Clinical Immunology)

Human bocavirus in hospitalized children, South Africa.

Emerging Infectious Diseases — Wed, 01 Nov 2006 21:49:02 +0100

Authors: Smuts H, Hardie D PMID: 17073104 [PubMed - in process] (Source: Emerging Infectious Diseases)

Human bocavirus infection among children, Jordan.

Emerging Infectious Diseases — Wed, 01 Nov 2006 21:49:02 +0100

Authors: Kaplan NM, Dove W, Abu-Zeid AF, Shamoon HE, Abd-Eldayem SA, Hart CA Human bocavirus was detected in 57 (18.3%) of 312 children with acute respiratory infection (ARI) who required hospitalization in Jordan. It was also detected in 30 (21.7%) of 138 children with severe ARI, in 27 (15.5%) of 174 with mild or moderate disease, and in 41 (72%) of 57 with other pathogens. PMID: 17073092 [PubMed - in process] (Source: Emerging Infectious Diseases)

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Human Bocavirus Infection in Young Children in the United States: Molecular Epidemiological Profile and Clinical Characteristics of a Newly Emerging Respiratory Virus

The Journal of Infectious Diseases Latest Articles — Wed, 27 Sep 2006 15:54:01 +0100

Background. Human bocavirus (HBoV) is a newly identified human parvovirus that was originally identified in the respiratory secretions of children with respiratory tract disease. To further investigate the epidemiological profile and clinical characteristics of HBoV infection, we screened infants and children (Source: The Journal of Infectious Diseases Latest Articles)

Epidemiological Profile and Clinical Associations of Human Bocavirus and Other Human Parvoviruses

The Journal of Infectious Diseases Latest Articles — Wed, 27 Sep 2006 15:54:01 +0100

Conclusions. In the present study, HBoV was a frequently detected, potential respiratory pathogen, with a prevalence and an epidemiological profile comparable to those of RSV. Identification of HBoV infections may be clinically important in the future. (Source: The Journal of Infectious Diseases Latest Articles)

Human Bocavirus: Developing Evidence for Pathogenicity

The Journal of Infectious Diseases Latest Articles — Wed, 27 Sep 2006 15:54:01 +0100

(Source: The Journal of Infectious Diseases Latest Articles)

Severe Pneumonia and Human Bocavirus in Adult, B. Kupfer et al.

Emerging Infectious Diseases Journal — Fri, 15 Sep 2006 22:38:01 +0100

(Source: Emerging Infectious Diseases Journal)

China Reports 6 Cases Tied to New Virus

AP Top Health News — Tue, 22 Aug 2006 15:16:14 +0100

BEIJING (AP) -- China has reported six cases of human bocavirus in children, the first infections in the country linked with the newly identified virus, the official Xinhua News Agency said Tuesday.... (Source: AP Top Health News)

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Human Bocavirus Infection among Children, Jordan, N.M. Kaplan et al.

Emerging Infectious Diseases Journal — Tue, 22 Aug 2006 10:10:06 +0100

(Source: Emerging Infectious Diseases Journal)

Bocavirus infection in hospitalized children, South Korea.

Emerging Infectious Diseases — Mon, 14 Aug 2006 06:00:00 +0100

This study presents the first evidence of human bocavirus infection in South Korean children. The virus was detected in 27 (8.0%) of 336 tested specimens, including 17 (7.5%) of 225 virus-negative specimens, collected from children with acute lower respiratory tract infection. PMID: 16965708 [PubMed - in process] (Source: Emerging Infectious Diseases)

Human bocavirus in French children.

Emerging Infectious Diseases — Mon, 14 Aug 2006 06:00:00 +0100

We report the epidemiologic and clinical features observed from a 1-year retrospective study of HBoV infection in young children hospitalized with a respiratory tract infection. PMID: 16965707 [PubMed - in process] (Source: Emerging Infectious Diseases)

Human Bocavirus in Hospitalized Children, South Africa, H. Smuts and D. Hardie

Emerging Infectious Diseases Journal — Sat, 05 Aug 2006 01:24:12 +0100

(Source: Emerging Infectious Diseases Journal)

Human Bocavirus in French Children, V. Foulongne et al.

Emerging Infectious Diseases Journal — Fri, 14 Jul 2006 06:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

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Bocavirus Infection in Hospitalized Children, South Korea, J.-Y. Chung et al.

Emerging Infectious Diseases Journal — Fri, 14 Jul 2006 06:00:00 +0100

(Source: Emerging Infectious Diseases Journal)

Frequent detection of Bocavirus DNA in German children with respiratory tract infections

BioMed Central — Tue, 11 Jul 2006 06:00:00 +0100

Conclusions: HBoV is frequently found in NPAs of hospitalized infants and children with acute respiratory tract diseases. Proving the clinical relevance of hBoV is challenging, because application of some of Kochs revised postulates is not possible. Because of the high rate of coinfections with hBoV and other respiratory tract pathogens, an association between hBoV and respiratory tract diseases remains unproven. (Source: BioMed Central)