MedWorm: Genital Herpes

Determinants of Per-Coital-Act HIV-1 Infectivity Among African HIV-1-Serodiscordant Couples.

Herpes — Fri, 20 Jan 2012 03:32:13 +0100

Conclusions. Modifiable risk factors for HIV-1 transmission were plasma HIV-1 RNA level and condom use, and, in HIV-1-uninfected partners, herpes simplex virus 2 infection, genital ulcers, Trichomonas vaginalis, vaginitis or cervicitis, and male circumcision. PMID: 22241800 [PubMed - as supplied by publisher] (Source: Herpes)

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Potential Infectious Etiology of Behçet's Disease.

Herpes — Fri, 20 Jan 2012 03:30:02 +0100

Authors: Galeone M, Colucci R, D'Erme AM, Moretti S, Lotti T Abstract Behçet's disease is a multisystem inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. The cause of Behçet's disease remains unknown, but epidemiologic findings suggest that an autoimmune process is triggered by an environmental agent in a genetically predisposed individual. An infectious agent could operate through molecular mimicry, and subsequently the disease could be perpetuated by an abnormal immune response to an autoantigen in the absence of ongoing infection. Potentia bacterial are Saccharomyces cerevisiae, mycobacteria, Borrelia burgdorferi, Helicobacter pylori, Escherichia coli, Staphylococcus aureus, and Mycoplasma fermentans, but the most...

The role of sexually transmitted infections in the evolution of the South African HIV epidemicRôle des infections sexuellement transmissibles dans l’évolution de l’épidémie du VIH en Afrique du sudEl papel de las infecciones de transmisión sexual en la evolución de la epidemia de VIH en Sudáfrica

Tropical Medicine and International Health — Thu, 19 Jan 2012 09:54:07 +0100

Conclusions Sexually transmitted infections have contributed significantly to the spread of HIV in South Africa, but STI control efforts have had limited impact on HIV incidence because of their late introduction and suboptimal coverage.Objectifs: Evaluer la mesure dans laquelle les infections sexuellement transmissibles (IST) ont contribuéà la propagation du VIH en Afrique du sud et estimer dans quelle mesure des améliorations dans le traitement des IST ont réduit l’incidence du VIH.Méthodes: Un modèle mathématique a été utilisé pour simuler les interactions entre le VIH et six autres IST (herpès génital, syphilis, chancre mou, blennorragie, infection à Chlamydia et à Trichomonas) ainsi que la vaginose bactérienne et la candidose vaginale. Les effets des IST sur ...

Lactoferricin but not lactoferrin inhibit herpes simplex virus type 2 infection in mice.

Antiviral Research — Mon, 16 Jan 2012 05:00:00 +0100

Authors: Shestakov A, Jenssen H, Nordström I, Eriksson K Abstract We have evaluated the potential of bovine lactoferrin and lactoferricin for their ability to prevent and/or treat genital HSV-2 infection in mice. We confirm previous data showing that both lactoferrin and lactoferricin have antiviral properties in vitro and can inhibit HSV-2 infection of GMK cells in a dose-dependent manner. When tested in vivo, lactoferricin but not lactoferrin was also a potent inhibitor of HSV-2 infection. When admixed with virus prior to inoculation, lactoferricin inhibited disease development and significantly reduced the viral load in a genital model of HSV-2 infection in mice. Lactoferrin and lactoferricin were also tested for their ability to stimulate the production of chemokines. Neither ...

Genital Herpes Vaccine - Research Progress

Health News from Medical News Today — Mon, 09 Jan 2012 15:00:00 +0100

A study published in the New England Journal of Medicine reveals that an investigational vaccine protected some women against infection from one of the two types of herpes simplex viruses that cause genital herpes. Leading author Robert Belshe, M.D., director of the Saint Louis University Center for Vaccine Development commented: "There is some very good news in our findings. We were partially successful against half of the equation - protecting women from genital disease caused by HSV-1... (Source: Health News from Medical News Today)

Genital Herpes Treatment - Virus Can Reactivate After Aggressive Antiviral Therapy

Health News from Medical News Today — Sun, 08 Jan 2012 18:00:00 +0100

According to a study in which three trials of antiviral therapy to treat genital herpes were combined, the herpes simplex virus type 2/HSV-2 can reactivate in 'breakthrough episodes' even when doses of antiviral therapy are high. The study is published Online First in The Lancet and suggests that new therapies should be conducted to successfully prevent further transmission of this common infection, which affects one in five people... (Source: Health News from Medical News Today)

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Hopeful Genital Herpes Vaccine Misses the MarkHopeful Genital Herpes Vaccine Misses the Mark

Medscape Today Headlines — Fri, 06 Jan 2012 17:06:54 +0100

The results are disappointing for many, but some see it as a step toward success. WebMD Health News (Source: Medscape Today Headlines)

Experimental herpes vaccine disappoints in study

Health News: CBSNews.com — Thu, 05 Jan 2012 17:25:09 +0100

Vaccine only protected against HSV-1 strain, but not HSV-2 - the most common cause of genital herpes (Source: Health News: CBSNews.com)

Herpes Drugs Don't Stop Herpes Spread

WebMD Health — Thu, 05 Jan 2012 16:45:16 +0100

People with genital herpes can still infect their sex partners -- even if they are taking anti-herpes drugs that prevent herpes outbreaks. (Source: WebMD Health)

Potential herpes vaccine disappoints researchers

USATODAY.com Health — Thu, 05 Jan 2012 15:43:54 +0100

A potential vaccine for genital herpes has shown limited effectiveness in thwarting one type of the sexually transmitted virus. (Source: USATODAY.com Health)

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Genital Herpes Vaccine Partially Successful

Health News from Medical News Today — Thu, 05 Jan 2012 10:00:00 +0100

Results of a clinical trial show that an investigational vaccine for genital herpes protected some women against infection from one of the two strains of virus that cause the disease. Although the results show only partial success, the researchers who conducted the trial believe they represent progress towards a genital herpes vaccine. They write about their findings in the 5 January online issue of the New England Journal of Medicine... (Source: Health News from Medical News Today)

Hopeful Genital Herpes Vaccine Misses the Mark

eMedicineHealth.com — Thu, 05 Jan 2012 07:00:00 +0100

(Source: eMedicineHealth.com)

Efficacy results of a trial of a herpes simplex vaccine.

Herpes — Thu, 05 Jan 2012 05:00:00 +0100

CONCLUSIONS: In a study population that was representative of the general population of HSV-1- and HSV-2-seronegative women, the investigational vaccine was effective in preventing HSV-1 genital disease and infection but not in preventing HSV-2 disease or infection. (Funded by the National Institute of Allergy and Infectious Diseases and GlaxoSmithKline; ClinicalTrials.gov number, NCT00057330.). PMID: 22216840 [PubMed - in process] (Source: Herpes)

HSV2 Suppressive Therapy Does Not Eliminate Viral SheddingHSV2 Suppressive Therapy Does Not Eliminate Viral Shedding

Medscape Today Headlines — Wed, 04 Jan 2012 23:35:00 +0100

Suppressive medicine for genital herpes reduces the number and duration of outbreaks but does not appear to prevent viral shedding that can result in transmission of virus. Medscape Medical News (Source: Medscape Today Headlines)

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Progress made toward a genital herpes vaccine

ScienceDaily Headlines — Wed, 04 Jan 2012 22:48:48 +0100

New research points investigators toward finding a genital herpes vaccine that works on both viruses that cause disease. (Source: ScienceDaily Headlines)

Hopeful Genital Herpes Vaccine Misses the Mark

WebMD Health — Wed, 04 Jan 2012 22:48:33 +0100

It's back to the drawing board for researchers seeking to develop a vaccine that protects against genital herpes. (Source: WebMD Health)

Potential Herpes Vaccine Disappoints Researchers

MedlinePlus Health News — Wed, 04 Jan 2012 22:00:00 +0100

Only partially effective against one type of virus, ineffective against second type, study found Source: HealthDay Related MedlinePlus Pages: Genital Herpes, Immunization, Sexually Transmitted Diseases (Source: MedlinePlus Health News)

Research shows progress toward a genital herpes vaccine

EurekAlert! - Social and Behavioral Science — Wed, 04 Jan 2012 05:00:00 +0100

(Saint Louis University) New NIH-funded research points investigators toward finding a genital herpes vaccine that works on both viruses that cause disease. (Source: EurekAlert! - Social and Behavioral Science)

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Potential Herpes Vaccine Disappoints Researchers

RWJF News Digest - Public Health — Wed, 04 Jan 2012 05:00:00 +0100

A potential vaccine for genital herpes has shown only limited effectiveness in thwarting one type of the sexually transmitted virus and no ability to stop a second type from spreading, a new study shows. (Source: RWJF News Digest - Public Health)

Epidemiology of Sexually Transmitted Infections, HIV, and Related High-Risk Behaviors among Female Sex Workers in Guangxi Autonomous Region, China.

Japanese Journal of Infectious Diseases — Sun, 01 Jan 2012 05:00:00 +0100

This study assessed the epidemiology of sexually transmitted infections (STIs), HIV, and associated risk factors among female sex workers (FSWs) in Guangxi autonomous region, China. A cross-sectional study of 488 FSWs was conducted using a structured questionnaire to collect sociodemographic and behavioral information. Biological specimens from subjects were sampled to detect various STIs and HIV infection. Among FSWs, the prevalence rates of syphilis, Neisseria gonorrhoeae, Chlamydia trachomatis, genital herpes, condyloma acuminate, and HIV were 7.2%, 1.8%, 18.2%, 0.4%, 2.3%, and 0.8%, respectively. The prevalence rates of single, double, and triple infections were 22.3%, 3.9%, and 0.20%, respectively. Multivariate analysis indicated that STIs and HIV infection was independently related t...

Study finds home birth is safe

NHS News Feed — Fri, 25 Nov 2011 17:55:00 +0100

This report will no doubt be of interest to parents who are planning where to have their baby and wish to discuss their options with their midwife or GP. What did the study look at? This large English study was designed to take a detailed look at risk associated with different birth settings for women with low-risk pregnancies. A low-risk pregnancy is one where the mother and baby are not affected by conditions or circumstances that can complicate the birth (see What is a low-risk pregnancy? for further details). The study compared home births, midwifery units run outside of a hospital setting, obstetric unit births in hospitals and births in ‘alongside midwifery units’, which are midwife-led units on a hospital site that also have an obstetric unit. Its analysis featured data on al...

Births at home or in hospital: risks explained

NHS News Feed — Fri, 25 Nov 2011 17:55:00 +0100

This report will no doubt be of interest to parents who are planning where to have their baby and wish to discuss their options with their midwife or GP. What did the study look at? This large English study was designed to take a detailed look at the risks associated with different settings where women with low-risk pregnancies planned to give birth. A low-risk pregnancy is one where the mother and baby are not affected by conditions or circumstances that can complicate the birth (see What is a low-risk pregnancy? for further details). The study compared home births, midwifery units run outside of a hospital setting, obstetric unit births in hospitals and births in ‘alongside midwifery units’, which are midwife-led units on a hospital site that also have an obstetric unit. Its anal...

'Not proper to men alone': herpes before the discovery of AIDS

Sexually Transmitted Infections — Tue, 22 Nov 2011 05:00:00 +0100

There is a lot of material dealing with herpes as a subject within the journal. However, most of it consists of papers dealing with the clinical aspects as opposed to the social side of the disease, reflected in the relatively small amount of sources addressing its stigmatisation. Herpes was first mentioned in the journal in 1963.1 In 1966, the first diagnosis of the disease was described by the Roman physician Herodotus, who noted ‘the herpetic eruptions which appeared about the mouth at the crisis of simple fevers, and the weals of febrile urticaria’.2 The first classic definition of genital herpes, recorded in France in 1736, was also referred to, already asserting that it occurred in both men and women: 'These disorders are not proper to men alone, but (mutatis mutandis) ar...

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Herpes simplex virus type 2 serological testing and psychosocial harm: a systematic review

Sexually Transmitted Infections — Tue, 22 Nov 2011 05:00:00 +0100

Conclusions HSV-2 diagnosis by type-specific serological testing did not result in long-term psychosocial harm in most persons without an identified history of genital herpes. Concerns about sustained emotional impact should not deter clinicians from offering HSV-2 serological testing to appropriate patients. (Source: Sexually Transmitted Infections)

Herpes simplex virus‐induced plasmacytic atypia

Journal of Cutaneous Pathology — Sat, 12 Nov 2011 05:00:00 +0100

We present the case of a patient carrying a previous diagnosis of pemphigus vulgaris, status posttreatment with methotrexate and prednisone, who developed a perineal ulcer exhibiting significant numbers of plasma cells, many of which were cytologically atypical. This morphology was suggestive of a hematopoietic malignancy. Immunoperoxidase staining for HSV decorated a focal collection of keratinocytes that lacked appreciable viral changes expected of HSV infection.Boyd AS, Zwerner JP, Miller JL. Herpes simplex virus‐induced plasmacytic atypia. (Source: Journal of Cutaneous Pathology)

Canine Reproductive, Respiratory, and Ocular Diseases due to Canine Herpesvirus

Veterinary Clinics of North America: Small Animal Practice — Tue, 01 Nov 2011 04:00:00 +0100

Although canine herpesvirus (CHV) (also referred to as canine herpesvirus 1, canid herpesvirus 1, neonatal herpes, genital herpes, ocular herpes, and CHV-1) infections and related diseases have been recognized since the early 1960s, there has been a resurgence of interest in the various clinical manifestations of the virus, which makes this review very timely. The various forms of CHV-associated infections are listed in . In some cases these infections were directly related to clinical symptoms, such as acute neonatal viremia resulting in puppy mortality; systemic viremia in naive pregnant females resulting in fetal death, abortion, and mummification; and ocular-respiratory disease in dogs of various age ranges. (Source: Veterinary Clinics of North America: Small Animal Practice)

Update on immunizations in adults.

American Family Physician — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Vaughn JA, Miller RA Abstract Vaccine-preventable diseases contribute significantly to the morbidity and mortality of U.S. adults. The Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention updates its recommended adult immunization schedule annually. The most recent updates include the permissive but not routine use of the quadrivalent human papillomavirus vaccine to prevent genital warts in males; a single dose of herpes zoster vaccine for adults 60 years and older, regardless of their history; replacing a single dose of tetanus and diphtheria toxoids (Td) vaccine with tetanus, diphtheria, and acellular pertussis (Tdap) vaccine in adults 19 years and older who have not previously received Tdap; expanding the indications for pneumoc...

New caesarean guidelines proposed

NHS News Feed — Mon, 31 Oct 2011 17:00:00 +0100

Several newspapers have reported that all pregnant women will “get the right to a caesarean”, regardless of whether there is a medical reason for having one. Currently, around one in four UK babies is delivered by caesarean. The reports are based on new draft guidelines from the National Institute for Health and Clinical Excellence (NICE), the national body that evaluates which treatments should be available for specific conditions. The proposed guidelines are the first major update from NICE on caesarean sections since 2004, and take into account the latest research on the procedure. What do the guidelines recommend? Although newspapers focused on caesareans potentially being available to a wider range of women, the draft guidelines cover all aspects of caesarean sections, includin...

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The role of sexually transmitted infections in the evolution of the South African HIV epidemic

Tropical Medicine and International Health — Mon, 31 Oct 2011 04:00:00 +0100

Symptoms of an Initial Outbreak of Genital Herpes

eMedicineHealth.com — Thu, 27 Oct 2011 07:00:00 +0100

(Source: eMedicineHealth.com)

Gel is swell against both HIV and herpes

Health Facts and Fears — Mon, 24 Oct 2011 04:00:00 +0100

A vaginal gel designed to reduce HIV infection may provide a surprisingly effective protection from genital herpes infection as well, reports a recent study published in Cell Host & Microbe. (Source: Health Facts and Fears)

Study Shows How Tenofovir Vaginal Gel May Block the Genital Herpes Virus

Fri, 21 Oct 2011 04:00:00 +0100

“An anti-HIV drug also discovered to stop the spread of the genital herpes virus does so by disabling a key DNA enzyme of the herpes virus, according to findings by researchers at the National Institutes of Health and other institutions. … “The findings explain the results of a recent clinical trial showing that the anti-HIV drug tenofovir, when it is formulated as a vaginal gel, could reduce the risk of herpes simplex virus (HSV) infections — as well as HIV infections — in women. “Tenofovir taken orally had been demonstrated to inhibit reproduction of HIV, but had not been known to block the genital herpes virus. “‘HIV infection is closely associated with herpes viral infection. When people with genital herpes are exposed to HIV, they a...

Gel Cuts Herpes Risk in Women, Study Finds

NYT Health — Fri, 21 Oct 2011 01:04:42 +0100

A vaginal gel that sharply cuts the risk of H.I.V. infection was found to be even more useful against genital herpes. (Source: NYT Health)

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NIH Researchers Show How Anti-HIV Drug Acts to Block Herpes Virus

MedlinePlus Health News — Thu, 20 Oct 2011 23:06:37 +0100

Source: National Institute of Child Health and Human Development - Related MedlinePlus Page: Genital Herpes (Source: MedlinePlus Health News)

Intrauterine Herpes Simplex Virus Infection Presenting with Hypopigmented Lesions

Pediatric Dermatology — Thu, 20 Oct 2011 04:00:00 +0100

Abstract: Genital herpes simplex virus (HSV) is a sexually transmitted infection that can be transmitted from mother to child in utero, perinatally, or postnatally. Cutaneous infection with HSV commonly presents as vesicles affecting the skin, eyes, or mouth. In our case, we report a well child with cutaneous hypopigmented patches at birth that preceded typical blistering. (Source: Pediatric Dermatology)

Email interviewing: generating data with a vulnerable population

Journal of Advanced Nursing — Mon, 17 Oct 2011 04:00:00 +0100

Conclusion. This method has the potential to enable nurses to include vulnerable and relatively inaccessible participants in ‘sensitive’ research. In‐depth email interviews may generate rich data through a process participants deem to be of personal value. (Source: Journal of Advanced Nursing)

Herpes simplex virus capsid assembly and DNA packaging: a present and future antiviral drug target.

Trends in Microbiology — Thu, 13 Oct 2011 04:00:00 +0100

Authors: Baines JD Abstract Herpes simplex virus (HSV) is an important pathogenic agent that causes recurrent oral and genital lesions, blindness and encephalitis. It is a member of the family Herpesviridae, which contains three subfamilies (alpha- beta- and gammaherpesvirinae) whose members infect humans to cause a variety of ailments, from benign rashes to nasopharyngeal carcinoma. Although this review focuses on HSV, the assembly steps that occur in the nucleus and the proteins involved are highly conserved among all family members, which suggests that antiviral agents that block these steps might be effective against many different herpesviruses and their associated diseases. Despite this potential, a broadly effective compound has yet to be realized, in part because many of th...

Understanding the HIV/AIDS Epidemic in Transgender Women of Lima, Peru: Results from a Sero-Epidemiologic Study Using Respondent Driven Sampling

AIDS and Behavior — Fri, 07 Oct 2011 15:57:16 +0100

We present results of the first seroepidemiologic study designed for transwomen in Peru. We conducted a study using respondent driven sampling to recruit transwomen from Lima. Our survey explored sociodemographic characteristics, gender enhancement procedures and sexual behavior. In addition, we conducted laboratory based HIV, genital herpes (HSV2) and syphilis testing. A total of 450 transwomen were recruited between April and July 2009. HIV prevalence was 30%, HSV2: 79% and syphilis: 23%. Sex-work was the main economic activity (64%). Gender enhancement procedures were reported by 70% of the population. Multivariable analysis showed HIV infection to be associated with being older than 35 recent, syphilis infection and HSV2 infection. Transwomen are the group most vulnerable to HIV/...

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Long-Term Oral Meds Cause Better Outcomes In Babies With HSV

Health News from Medical News Today — Thu, 06 Oct 2011 08:00:00 +0100

A silent disease found in one-fifth of American females can be passed on to newborn babies, and the results can be tragic brain damage or death. But researchers at the University of Alabama at Birmingham have found a new method of suppression, as reported in the Oct. 6, 2011 edition of the New England Journal of Medicine. "Neonatal herpes simplex virus (HSV) occurs primarily when a mother who has genital herpes transmits it to the baby," says David Kimberlin, M.D., UAB professor of pediatrics and president-elect of the Pediatric Infectious Diseases Society... (Source: Health News from Medical News Today)

RCTs: Oral aciclovir suppression and neurodevelopment after neonatal herpes

NeLM - News — Thu, 06 Oct 2011 04:00:00 +0100

Source: N Engl J Med Area: News The outcomes of neonatal herpes simplex virus (HSV) disease are dependent on the extent of the disease. Approximately 30% of babies with disseminated disease die, but only 20% of survivors have neurological sequelae. In contrast, only 6% of babies with CNS disease die, but approximately 70% have permanent neurological impairment. Antiviral suppressive therapy prevents the recurrence of localised disease in patients with genital or orolabial HSV infection. The National Institute of Allergy and Infectious Diseases (NIAID) Collaborative Antiviral Study Group (CASG) conducted parallel, identical, phase III, placebo-controlled studies of oral acyclovir suppressive therapy after neonatal HSV disease to determine the efficacy and safety of long-term antiviral admi...

Vical Reports Prophylactic and Therapeutic Efficacy With Herpes Simplex Vaccines in Guinea Pig Model

Medical News (via PRIMEZONE) — Mon, 03 Oct 2011 10:30:00 +0100

SEATTLE, Oct. 3, 2011 (GLOBE NEWSWIRE) -- Vical Incorporated (Nasdaq:VICL) today announced that its Vaxfectin(r)-formulated plasmid DNA (pDNA) vaccines against herpes simplex virus type 2 (HSV-2) provided complete protection in guinea pigs against both primary and recurrent HSV-2 disease. The vaccines also significantly reduced genital lesion recurrence and viral shedding as well as latent infection in the central nervous system. (Source: Medical News (via PRIMEZONE))

Seroepidemiology of herpes simplex virus type 1 and 2 in pregnant women in Switzerland: an obstetric clinic based study

European Journal of Obstetrics, Gynecology, and Reproductive Biology — Mon, 03 Oct 2011 04:00:00 +0100

Conclusion: Compared to a previous population-based study, our study results suggest a rise in the prevalence of HSV-2 among pregnant women in Switzerland. The low incidence of seroconversion detected during pregnancy is consistent with the very low reported incidence of neonatal herpes in Switzerland.Condensation: This study in a public hospital in Western Switzerland suggests an increasing prevalence of HSV-2, but a low incidence of primary infections in women of childbearing age. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)

Single and combination herpes simplex virus type 2 glycoprotein vaccines adjuvanted with CpG oligodeoxynucleotides or monophosphoryl lipid a exhibit differential immunity that is not correlated to protection in animal models.

Clinical and Vaccine Immunology — Sat, 01 Oct 2011 04:00:00 +0100

Authors: Khodai T, Chappell D, Christy C, Cockle P, Eyles J, Hammond D, Gore K, McCluskie MJ, Evans DM, Lang S, Loudon PT, Townend T, Wright P, West K, Bright H Abstract Despite several attempts to develop an effective prophylactic vaccine for HSV-2, all have failed to show efficacy in the clinic. The most recent of these failures was the GlaxoSmithKline (GSK) subunit vaccine based on the glycoprotein gD with the adjuvant monophosphoryl lipid A (MPL). In a phase 3 clinical trial, this vaccine failed to protect from HSV-2 disease, even though good neutralizing antibody responses were elicited. We aimed to develop a superior, novel HSV-2 vaccine containing either gD or gB alone or in combination, together with the potent adjuvant CpG oligodeoxynucleotides (CPG). The immunogenic prope...

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Check-up genital herpes

The Irish Times - Health — Mon, 26 Sep 2011 23:42:38 +0100

What causes genital herpes? (Source: The Irish Times - Health)

Genital herpes in children under 11 years and investigations for sexual abuse. - Reading R, Hughes G, Hill J, Debelle G.

SafetyLit: All (Unduplicated) — Fri, 23 Sep 2011 01:20:07 +0100

Objective The implications for sexual abuse investigation of genital herpes in a child are uncertain because of a lack of good quality research evidence. The incidence, presenting features, history of exposure, indicators of child maltreatment and outcomes... (Source: SafetyLit: All (Unduplicated))

Genital primary herpes simplex infection in a 5-month-old infant.

Dermatol Online J — Thu, 15 Sep 2011 21:44:02 +0100

We report a case of genital primary herpetic infection in a 5-month-old male, exclusively breastfed, whose mother suffered from active labial herpes. PMID: 21906488 [PubMed - in process] (Source: Dermatol Online J)

Primary syphilis of the urethral meatus complicated by urethral stricture

International Journal of STD and AIDS — Thu, 01 Sep 2011 23:00:00 +0100

A 27-year-old man who has sex with men presented with a painful lesion at the urethral meatus. A diagnosis of genital herpes was suspected, and initial tests for sexually transmitted infections (STIs), including syphilis serology, were negative. However, a polymerase chain reaction (PCR) swab for Treponema pallidum from the lesion was positive, and a diagnosis of chancre of primary syphilis at the meatus was made. Subsequently, the patient required urological surgery due to the formation of a urethral stricture. Chancre at the meatus and development of stricture are unusual complications of syphilis that may become more common in the future with increasing case numbers. We also discuss the development of PCR as a useful test for early primary syphilis. (Source: International Journal of STD...

Boy, 11, among 1,000 under-16s treated for sexually transmitted infections

the Mail online | Health — Mon, 29 Aug 2011 12:08:05 +0100

Two boys of 12 were also treated for genital warts and herpes by Chelsea and Westminster Foundation Trust, while the 11-year-old was treated for chlamydia. (Source: the Mail online | Health)

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The role of coinfections in HIV epidemic trajectory and positive prevention: a systematic review and meta-analysis

AIDS — Wed, 24 Aug 2011 05:00:00 +0100

Conclusion: Coinfections may increase HIV viral load in populations where they are prevalent, thereby facilitating HIV transmission. These effects may be reversed with treatment. However, to limit HIV trajectory and optimize positive prevention for HIV-infected individuals pre-antiretroviral therapy, we must better understand the mechanisms responsible for augmented viral load and the magnitude of viral load reduction required, and retune treatment regimens accordingly. (Source: AIDS)

Herpes Simplex Virus Genital Infections: Current Concepts

Current Infectious Disease Reports — Mon, 22 Aug 2011 15:58:35 +0100

Abstract Genital herpes is a common sexually transmitted disease that is frequently undiagnosed. Viral shedding occurs frequently and often without symptoms facilitating transmission to sex partners. Genital herpes may impact HIV transmission, and may be transmitted to neonates at the time of birth. Primary prevention of genital herpes is needed to lower the burden of disease. Content Type Journal ArticleCategory Urinary Tract Infections (Jack D. Sobel, Section Editor)Pages 1-7DOI 10.1007/s11908-011-0209-5Authors Carolyn Gardella, Departments of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195-6460, USA Journal Current Infectious Disease ReportsOnline ISSN 1534-3146Print ISSN 1523-3847 (Source: Current Infectious Disease Reports)

Prevalence of human papillomavirus genotypes and associated cervical squamous intraepithelial lesions in HIV-infected women in Botswana.

Herpes — Sat, 20 Aug 2011 14:32:41 +0100

Authors: Macleod IJ, O'Donnell B, Moyo S, Lockman S, Shapiro RL, Kayembe M, van Widenfelt E, Makhema J, Essex M, Wester C Abstract Human papillomaviruses (HPV) constitute one of the most prevalent sexually transmitted infections and are the etiological agents for invasive cervical cancer, the predominant cancer among women in Botswana. However, the prevalence of HPV genotypes in Botswana has yet to be reported. One hundred thirty-nine endocervical swabs were taken at baseline from HIV-1 infected, HSV-2 seropositive women enrolled in a longitudinal cohort study designed to assess the influence of herpes simplex virus-2 (HSV-2) infection on genital tract shedding of HIV-1. Extracted DNA was evaluated for the presence of low-risk and high-risk HPV using the Roche Linear Array. Genotyp...

Evaluation of patients' preferences for genital herpes treatment.

Herpes — Sat, 20 Aug 2011 14:32:30 +0100

CONCLUSIONS: : Subjects' preferences are influenced by both the treatment they follow and attributes of treatment including cost. Knowledge of patients' preferences, together with their clinical status, could help decision-makers to optimize therapy uptake and success. PMID: 21844733 [PubMed - in process] (Source: Herpes)

Factors associated with herpes simplex virus type 2 incidence in a cohort of human immunodeficiency virus type 1-seronegative kenyan men and women reporting high-risk sexual behavior.

Herpes — Sat, 20 Aug 2011 14:32:20 +0100

CONCLUSIONS: : HSV-2 incidence in these men and women is among the highest reported, and is associated with HIV-1 acquisition. Although vaginal washing with soap may increase HSV-2 risk in women, genital hygiene may be protective in men. PMID: 21844740 [PubMed - in process] (Source: Herpes)

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Health Care Seeking Among Men With Genital Ulcer Disease in South Africa: Correlates and Relationship to Human Immunodeficiency Virus-1 and Herpes Simplex Virus Type 2 Detection and Shedding.

Herpes — Sat, 20 Aug 2011 14:32:15 +0100

CONCLUSIONS:: Interventions to help shorten the duration between ulcer recognition and health care seeking for men with GUD are needed. PMID: 21844743 [PubMed - as supplied by publisher] (Source: Herpes)

MedlinePlus: Herpes genital

NLM General Announcements — Fri, 19 Aug 2011 06:04:18 +0100

(Source: NLM General Announcements)

New Topic Page: Genital Herpes

What's New on MedlinePlus — Thu, 18 Aug 2011 23:11:18 +0100

Visit the new MedlinePlus Health Topic page on genital herpes. Genital herpes is a sexually transmitted disease (STD) caused by a herpes simplex virus (HSV). It can cause sores on your genital or rectal area, buttocks, and thighs... (Source: What's New on MedlinePlus)

DNA Viruses (CMV, EBV, and the Herpesviruses)

Seminars in Respiratory and Critical Care Medicine — Thu, 18 Aug 2011 23:00:00 +0100

This article discusses the individual pathogens, preventive strategies in the era of potent treatment regimens for established viral infection or disease and their potential impact on the indirect effects of these viruses on long-term allograft function, and the incidence, risk factors for, and impact of antiviral resistance.[...]© Thieme Medical PublishersArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Seminars in Respiratory and Critical Care Medicine)

MedlinePlus: Genital Herpes

NLM General Announcements — Thu, 18 Aug 2011 05:01:03 +0100

(Source: NLM General Announcements)

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THT statement on the first criminal conviction for herpes transmission

Terrence Higgins Trust — Tue, 16 Aug 2011 14:17:29 +0100

THT's Director of Policy, Lisa Power, said: "This case highlights the ridiculousness of using criminal law to police disease transmission. Genital herpes is a virus that can lie dormant for years, is hard to predict or control and routinely affects thousands of people. "Currently, we are using Victorian assault laws to criminalise disease transmission, but only when this occurs sexually. This is discriminatory and stigmatising and current sentencing is out of all proportion to the impact of the "offence". There is a shameful lack of understanding of sexually transmitted infections within the justice system and this case perfectly illustrates the problem."Notes to Editor1. Terrence Higgins Trust is the UK’s largest HIV and sexual health charity with centres across England, Scotland and W...

Prevalence of human papillomavirus genotypes and associated cervical squamous intraepithelial lesions in HIV‐infected women in Botswana

Journal of Medical Virology — Thu, 11 Aug 2011 18:51:54 +0100

AbstractHuman papillomaviruses (HPV) constitute one of the most prevalent sexually transmitted infections and are the etiological agents for invasive cervical cancer, the predominant cancer among women in Botswana. However, the prevalence of HPV genotypes in Botswana has yet to be reported.One hundred thirty‐nine endocervical swabs were taken at baseline from HIV‐1 infected, HSV‐2 seropositive women enrolled in a longitudinal cohort study designed to assess the influence of herpes simplex virus‐2 (HSV‐2) infection on genital tract shedding of HIV‐1. Extracted DNA was evaluated for the presence of low‐risk and high‐risk HPV using the Roche Linear Array.Genotyping identified HPV in 95 of 139 women of which 61/95 were infected with high‐risk HPV and 56/95 with low‐risk HPV...

Patterns of herpes simplex virus shedding over 1 month and the impact of acyclovir and HIV in HSV-2-seropositive women in Tanzania

Sexually Transmitted Infections — Mon, 18 Jul 2011 23:00:00 +0100

Conclusions HSV shedding was common, varying greatly by individual. Shedding rates were similar to studies in African and non-African settings. Among HIV-negative women, shedding rates were lower in the acyclovir arm; however, acyclovir did not substantially impact on HSV shedding in HIV-positive women. (Source: Sexually Transmitted Infections)

AiCuris' Novel HSV Compound AIC316 Shows Efficacy In Phase II

Health News from Medical News Today — Mon, 18 Jul 2011 11:00:00 +0100

Phase II results for AiCuris' novel non-nucleosidic herpes simplex virus (HSV) inhibitor AIC316 reveal safety and efficacy in persons with genital herpes. The data were presented at the 19th ISSTDR Meeting (International Society for Sexually Transmitted Diseases Research) in Quebec, Canada, by the coordinating investigator of the trial, Professor Anna Wald from the University of Washington and Fred Hutchinson Cancer Research Center in Seattle, USA. 156 HSV-2 positive participants (105 women and 51 men) were randomized between May 2010 and October 2010 at seven sites in the US... (Source: Health News from Medical News Today)

Why don't the over-50s get the safe sex message? New figures reveal huge rise in STIs

the Mail online | Health — Sat, 16 Jul 2011 21:35:51 +0100

Genital herpes is up 15 per cent in the past year and 142 per cent in ten years, while gonorrhoea is up eight per cent in one year and 14 per cent since 2001. (Source: the Mail online | Health)

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A heat shock protein based polyvalent vaccine targeting HSV-2: CD4(+) and CD8(+) cellular immunity and protective efficacy.

Vaccine — Thu, 14 Jul 2011 23:00:00 +0100

We present here results of a therapeutic vaccine candidate, HerpV (formerly called AG-707), consisting of 32 HSV-2 peptides derived from 22 HSV-2 proteins, complexed non-covalently to the HSP70 chaperone and formulated with QS-21 saponin adjuvant. HerpV is observed to be immunogenic, generating CD4(+) and CD8(+) T cell responses in three mouse strains including HLA-A2 transgenic mice. Optimal T cell stimulation was dependent on the synergistic adjuvant properties of QS-21 with hsp70. The vaccine provided significant protection from viral challenge in a mouse prophylaxis model and showed signals of activity in a guinea pig therapeutic model of existing infection. Peripheral blood mononuclear cells from human HSV-2(+) subjects also showed reactivity in vitro to a subset of individual peptide...

Hyperaesthesia following genital herpes: a case report.

Herpes — Wed, 13 Jul 2011 17:45:03 +0100

We report an adult female patient who presented with sacral radiculopathy as incapacitating dysthesias following primary genital herpes simplex, which later recurred. Despite use of systemic antiviral treatment, the painful syndrome in our patient persisted. The success in treatment was seen only after the addition of amitriptyline hydrochloride. The case is being presented here for its rare manifestation and novel use of amitriptyline hydrochloride. PMID: 21747842 [PubMed - in process] (Source: Herpes)

Terrence Higgins Trust drive to get men ‘match fit’ this summer

Terrence Higgins Trust — Wed, 13 Jul 2011 09:52:40 +0100

Charity Terrence Higgins Trust (THT) is encouraging all sexually active men in the Bedford area to get themselves ‘match ready’ for the upcoming football and rugby season by having a sexual health check as part of their routine healthcare this summer.The charity offers six free walk-in sexual health clinics a week from Monday to Saturday, and is running a men-only session on Wednesday evenings, between 6pm and 8pm, to enable more local men to access these vital and confidential services.Recent east of England statistics from The Health Protection Agency, released last month, have shown an increase in a number of sexually transmitted infections (STIs) including a 9% rise in syphilis and a 17% rise in genital herpes within men between 2009 and 2010. It's therefore vital men get themselve...

Genital herpes in children under 11 years and investigations for sexual abuse

Archives of Disease in Childhood — Mon, 11 Jul 2011 23:00:00 +0100

Conclusions Genital herpes in children under 11 years is rare. Almost a third of children diagnosed with genital herpes did not have appropriate virological investigation and few were screened for other STIs. Around a quarter of cases were referred to child protection agencies for further investigation, which limits any inferences in this study about mode of transmission in children. Sexual abuse guidance should emphasise the need for thorough assessment and investigation in cases of genital herpes in children. (Source: Archives of Disease in Childhood)

Marine organisms as a therapeutic source against herpes simplex virus infection.

European Journal of Pharmaceutical Sciences — Mon, 11 Jul 2011 23:00:00 +0100

Authors: Vo TS, Ngo DH, Ta QV, Kim SK Herpes simplex virus (HSV) is a member of the Herpesviridae family that causes general communicable infections in human populations throughout the world, the most common being genital and orolabial disease. The current treatments for HSV infections are nucleoside analogs such as acyclovir, valacyclovir and famciclovir. Despite the safety and efficacy, extensive clinical use of these drugs has led to the emergence of resistant viral strains, mainly in immunocompromised patients. To counteract these problems, alternative anti-HSV agents from natural products have been reported. Recently, a great deal of interest has been expressed regarding marine organisms such as algae, sponges, tunicates, echinoderms, mollusks, shrimp, bacteria, and fungus as prom...

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Knowledge of sexually transmissible infections: a comparison of prisoners and the general population

International Journal of STD and AIDS — Mon, 04 Jul 2011 23:00:00 +0100

The World Health Organization (WHO) has identified a failure to provide education for vulnerable populations such as prisoners as a contributing factor to the epidemic of sexually transmissible infections (STIs). Despite this recognition, little is known about prisoners' level of knowledge of STIs compared with the general population. Using computer-assisted telephone interviews, we compared a representative sample of 2289 Australian prisoners, aged 18–59 years from New South Wales and Queensland prisons with a representative community sample of 3536 participants from these two states. Prisoners had significantly better knowledge than the general community of chlamydia-related questions, while knowledge of herpes (genital and oral) was slightly better in the community sample. Prisone...

Knowledge of sexually transmissible infections: a comparison of prisoners and the general population.

Herpes — Thu, 30 Jun 2011 23:00:00 +0100

Authors: Malacova E, Butler T, Richters J, Yap L, Grant L, Richards A, Smith AM, Donovan B The World Health Organization (WHO) has identified a failure to provide education for vulnerable populations such as prisoners as a contributing factor to the epidemic of sexually transmissible infections (STIs). Despite this recognition, little is known about prisoners' level of knowledge of STIs compared with the general population. Using computer-assisted telephone interviews, we compared a representative sample of 2289 Australian prisoners, aged 18-59 years from New South Wales and Queensland prisons with a representative community sample of 3536 participants from these two states. Prisoners had significantly better knowledge than the general community of chlamydia-related questions, while kn...

What you need to know about genital herpes.

Herpes — Tue, 28 Jun 2011 10:50:34 +0100

Authors: Snow M PMID: 21670657 [PubMed - in process] (Source: Herpes)

Endometrial Epithelial Cell Responses to Coinfecting Viral and Bacterial Pathogens in the Genital Tract Can Activate the HIV-1 LTR in an NF{kappa}B-and AP-1-Dependent Manner.

Herpes — Tue, 28 Jun 2011 10:50:06 +0100

Conclusions. STIs may increase HIV-1 replication in the female genital tract via proinflammatory signaling pathways directly and indirectly via their effects on GECs. This increased HIV-1 replication may enhance sexual and vertical HIV transmission. PMID: 21673042 [PubMed - in process] (Source: Herpes)

Getting research into policy - Herpes simplex virus type-2 (HSV-2) treatment and HIV infection: international guidelines formulation and the case of Ghana.

Herpes — Tue, 28 Jun 2011 10:45:04 +0100

Authors: Burris H, Parkhurst J, Adu-Sarkodie Y, Mayaud P Observational epidemiological and biological data indicate clear synergies between Herpes simplex virus type 2 (HSV-2) and HIV, whereby HSV-2 enhances the potential for HIV acquisition or transmission. In 2001, the World Health Organization (WHO) launched a call for research into the possibilities of disrupting this cofactor effect through the use of antiherpetic therapy. A WHO Expert Meeting was convened in 2008 to review the research results. The results of the trials were mostly inconclusive or showed no impact. However, the WHO syndromic management treatment guidelines were modified to include acyclovir as first line therapy to treat genital ulcer disease on the basis of the high prevalence of HSV-2 in most settings, impact a...

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Identity of zinc finger nucleases with specificity to Herpes simplex virus type II genomic DNA: novel HSV-2 vaccine/ therapy precursors

Theoretical Biology and Medical Modelling — Thu, 23 Jun 2011 23:00:00 +0100

Conclusion: ZFNs with specificity to HSV-2 genomic DNA that are precursors of novel host-genome expressed HSV-2 gene-therapeutics or vaccines were identified. (Source: Theoretical Biology and Medical Modelling)

Identity of zinc finger nucleases with specificity to Herpes simplex virus type II genomic DNA: novel HSV-2 vaccine/ therapy precursors.

Herpes — Thu, 23 Jun 2011 23:00:00 +0100

CONCLUSION: ZFNs with specificity to HSV-2 genomic DNA that are precursors of novel host-genome expressed HSV-2 gene-therapeutics or vaccines were identified. PMID: 21702927 [PubMed - as supplied by publisher] (Source: Herpes)

Why Do Young Women Get Tested for Sexually Transmitted Infections? Evidence from The National Longitudinal Study of Adolescent Health.

Herpes — Sun, 19 Jun 2011 23:00:00 +0100

Conclusions: Education efforts in secondary school health programs and during gynecologic examinations can decrease confusion about STI testing. PMID: 21689024 [PubMed - as supplied by publisher] (Source: Herpes)

FPA Welcomes Decrease In Sexually Transmitted Infections (STIs) For First Time In A Decade, UK

Health News from Medical News Today — Wed, 15 Jun 2011 15:00:00 +0100

Figures released today by the Health Protection Agency (HPA) show a small decrease of one per cent in the number of new sexually transmitted infections (STIs) reported in England during 2010, particularly amongst the 15 to 24 year old age group. While gonorrhoea and genital herpes are on the increase, chlamydia diagnoses stabilised for the first time and both genital warts and syphilis figures were down... (Source: Health News from Medical News Today)

South Africa: New Test Phase of HIV Gel Launched

AllAfrica News: HIV-Aids and STDs — Tue, 14 Jun 2011 13:24:47 +0100

After encouraging results on a vaginal gel containing the antiretroviral drug tenofovir, which reduces HIV infection and risk of contracting genital herpes, a follow-up study to test the safety of the gel has been launched. (Source: AllAfrica News: HIV-Aids and STDs)

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Genital herpes in children under 11 years and investigations for sexual abuse.

Herpes — Mon, 13 Jun 2011 23:00:00 +0100

The effects of daily distress and personality on genital HSV shedding and lesions in a randomized, double-blind, placebo-controlled, crossover trial of acyclovir in HSV-2 seropositive women.

Herpes — Sun, 12 Jun 2011 23:00:00 +0100

We report results from a randomized, double-blind, placebo-controlled, crossover trial of acyclovir in 19 women for whom personality was assessed at baseline and daily assessments of genital lesions, stress, anxiety, and depression levels were collected for 22weeks. In addition, daily swabs of the genital mucosa were collected to assess HSV-2 viral reactivation. We found that daily stress predicted genital lesion frequency, and that daily stress, anxiety, and depression predicted genital lesion onset approximately 5days before onset. Anxiety was also associated with genital lesions 3days after onset. Distress and viral reactivation were not associated; and no personality traits were associated with any of the outcomes. These results support the hypothesis that psychological distress is bot...

Prenatal Infection and Immune Models of Schizophrenia

Springer protocols feed by Neuroscience — Thu, 09 Jun 2011 01:33:17 +0100

An increasing number of epidemiologic studies have implicated in utero exposure to infection in the etiopathogenesis of schizophrenia. Recent work has capitalized on the use of prospectively acquired data on infection based on maternal biomarkers. These studies suggest that several maternal infections, including rubella, influenza, toxoplasmosis, herpes simplex virus/other genital-reproductive infections, and elevations in the cytokines interleukin-8 and TNF-a, are associated with increased schizophrenia risk among offspring. Animal models of in utero infection offer the potential to corroborate these findings under controlled conditions and address etiopathogenic mechanisms. Models of maternal immune activation (MIA) and behavioral and brain anomalies in schizophrenia have primarily emplo...

Concurrent detection of herpes simplex and varicella-zoster viruses by polymerase chain reaction from the same anatomic location

Diagnostic Microbiology and Infectious Disease — Wed, 08 Jun 2011 23:00:00 +0100

Abstract: Herpes simplex virus (HSV) and varicella-zoster virus (VZV) may cause latent infection of the same peripheral nerve ganglia. However, there are no large studies addressing the frequency of concurrent HSV/VZV PCR positivity from the same anatomic location. In an eight-year retrospective study, we observed 1.3% dual positivity from dermal, genital, and oral mucosal sources. (Source: Diagnostic Microbiology and Infectious Disease)

Seroprevalence, predictors and estimated incidence of maternal and neonatal Herpes Simplex Virus Type 2 Infection in semi-urban women in Kilifi, Kenya

BMC Infectious Diseases — Mon, 30 May 2011 23:00:00 +0100

Background: Herpes Simplex Virus type 2 (HSV-2) has public health importance as a leading cause of genital ulcers, a co-factor in HIV-1 acquisition and transmission and as a cause of neonatal herpes infections. Little is known of its epidemiology and burden in Coastal Kenya. Methods: We screened plasma samples for HSV-2 infection from 826 women aged 15-34 years who participated in an HIV-1 survey in Kilifi in 2004. The sample comprised 563 women selected randomly from a demographic surveillance system (DSS) and 263 women who presented for voluntary counseling and testing (VCT). Predictors for HSV-2 seropositivity were determined using multivariate logistic regression. The incidence of HSV-2 infection and risk of neonatal herpes were estimated by a simple catalytic model fitted to age-serop...

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STD Symptoms

About.com Eating Disorders — Thu, 26 May 2011 23:00:00 +0100

Review the symptoms of common STDs, like chlamydia, genital herpes, gonorrhea, and syphilis. (Source: About.com Eating Disorders)

Herpes Symptoms in Women

About.com Eating Disorders — Thu, 26 May 2011 23:00:00 +0100

Even though the herpes simplex virus can infect men and women, the pattern of infection is different in women. Learn more about the symptoms women can get with genital herpes. (Source: About.com Eating Disorders)

First Genital Herpes Outbreak

About.com Eating Disorders — Thu, 26 May 2011 23:00:00 +0100

The first outbreak of genital herpes is worse than recurrent genital herpes virus infections. Find out more about how the herpes simplex virus causes the first genital herpes outbreak. (Source: About.com Eating Disorders)

Prevalence and risk factors for herpes simplex infection among patients at high risk for HIV infection in Brazil

International Journal of Dermatology — Fri, 20 May 2011 15:49:44 +0100

Conclusion Educational campaigns, with particular focus on the transmission of HSV, and the regular use of condoms are important measures to reduce the HSV dissemination among patients with less advanced educations and at high risk for STDs. (Source: International Journal of Dermatology)

Trimester dependent preterm births in pregnancy with genital herpes

Central European Journal of Medicine — Wed, 18 May 2011 18:21:03 +0100

In conclusion, clinically diagnosed recurrent genital herpes during the third trimester of pregnancy associated with high risk for preterm birth. Content Type Journal ArticlePages 1-7DOI 10.2478/s11536-011-0044-yAuthors Ferenc Bánhidy, Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Üllői út 78/A, H-1082 Budapest, HungaryIstván Dudás, Foundation for the Community Control of Hereditary Diseases, Bolgárkerék utca 3, H-1148 Budapest, HungaryAndrew E. Czeizel, Foundation for the Community Control of Hereditary Diseases, Bolgárkerék utca 3, H-1148 Budapest, Hungary Journal Central European Journal of MedicineOnline ISSN 1644-3640Print ISSN 1895-1058 (Source: Central European Journal of Medicine)

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High prevalent and incident HIV-1 and herpes simplex virus 2 infection among male migrant and non-migrant sugar farm workers in Zambia

Sexually Transmitted Infections — Tue, 17 May 2011 23:00:00 +0100

Conclusions HIV-1 prevalence and incidence were high, and HSV-2 infection was a risk factor for HIV-1 acquisition. There is an urgent need to expand HIV-1 prevention programmes tailored to farm workers and their communities. (Source: Sexually Transmitted Infections)

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

Journal of Clinical Investigation — Mon, 16 May 2011 18:24:11 +0100

The continued spread of the HIV epidemic underscores the need to interrupt transmission. One attractive strategy is a topical vaginal microbicide. Sexual transmission of herpes simplex virus type 2 (HSV-2) in mice can be inhibited by intravaginal siRNA application. To overcome the challenges of knocking down gene expression in immune cells susceptible to HIV infection, we used chimeric RNAs composed of an aptamer fused to an siRNA for targeted gene knockdown in cells bearing an aptamer-binding receptor. Here, we showed that CD4 aptamer-siRNA chimeras (CD4-AsiCs) specifically suppress gene expression in CD4+ T cells and macrophages in vitro, in polarized cervicovaginal tissue explants, and in the female genital tract of humanized mice. CD4-AsiCs do not activate lymphocytes or stimulate inna...

Design and evaluation of a Multi-Epitope Assembly Peptide (MEAP) against Herpes Simplex Virus Type 2 infection in BALB/c mice

Virology Journal — Sun, 15 May 2011 23:00:00 +0100

Conclusions: The MEAP provided complete protection against infection with HSV-2 in mice, which indicates that it might be a potential candidate vaccine against HSV-2. (Source: Virology Journal)

Quantitative and qualitative correlates of cervicovaginal herpes simplex virus type 2 shedding among HIV-infected women in the Women's Interagency HIV Study

International Journal of STD and AIDS — Thu, 12 May 2011 23:00:00 +0100

This study provides genital HSV-2 DNA titre as a quantitative and symptom- and sign-based measures as qualitative predictors of HSV-2 shedding from the lower genital tract among HIV-infected women. (Source: International Journal of STD and AIDS)

Gov't: Some Products Falsely Claim to Treat STDs

WebMD Health — Wed, 04 May 2011 20:00:56 +0100

Two federal agencies are cracking down on bogus claims made by companies that tout their products as treatments, cures, or preventive medications for sexually transmitted diseases such as herpes, genital warts, and HIV, the virus that causes AIDS. (Source: WebMD Health)

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U.S. targets bogus cures for herpes, other STIs

CTV Health — Wed, 04 May 2011 12:06:36 +0100

The Internet abounds with bogus pills and herbal supplements that claim to cure sexually transmitted infections like herpes, chlamydia and genital warts. Now, health officials in the U.S. are cracking down. (Source: CTV Health)

FDA Warns: Beware of Bogus STD Products

MedlinePlus Health News — Tue, 03 May 2011 21:15:07 +0100

Source: Food and Drug Administration - Related MedlinePlus Pages: Chlamydia Infections, Genital Warts, HIV/AIDS, Herpes Simplex, Sexually Transmitted Diseases (Source: MedlinePlus Health News)

Pregnancy Outcome in Female Liver Transplant Recipients

Transplantation Proceedings — Sat, 30 Apr 2011 23:00:00 +0100

Abstract: Transplantation has become an available and successful treatment option for numerous congenital and acquired hepatic disorders. Studies have shown that when the prepregnancy recipient graft function is stable and adequate, pregnancy is normally well tolerated with favorable neonatal outcomes. However, there are reports of increased incidences of hypertension and preeclampsia as well as lower birth weights and prematurity. Patients administered tacrolimus-based therapies seem to have lower incidences of these complications.Case Reports: The 5 reported patients, aged 23–37 years at the time of conception, were 2–11 years posttransplantation. A preterm delivery for fetal distress was the most clinically important complication among these patients. One episode of acute genital he...

Using centralized laboratory data to monitor trends in herpes simplex virus type 1 and 2 infection in British Columbia and the changing etiology of genital herpes.

Canadian Journal of Public Health — Sat, 30 Apr 2011 23:00:00 +0100

Authors: Gilbert M, Li X, Petric M, Krajden M, Isaac-Renton JL, Ogilvie G, Rekart ML Understanding the regional epidemiology of genital Herpes Simplex Virus (HSV) infections is important for clinical and public health practice, due to the increasing availability of type-specific serologic testing in Canada and the contribution of genital HSV-2 infection to ongoing HIV transmission. We used centralized laboratory data to describe trends in viral identifications of genital HSV in BC and assess the utility of these data for ongoing population surveillance. PMID: 21714324 [PubMed - in process] (Source: Canadian Journal of Public Health)

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Tumour-like presentations of anogenital herpes simplex in HIV-positive patients

International Journal of STD and AIDS — Thu, 21 Apr 2011 23:00:00 +0100

We describe five immunocompromised HIV-positive patients with CD4 counts ranging from 114 to 326 cells/µL with unusual presentations of anogenital herpes. (Source: International Journal of STD and AIDS)

Study: Genital herpes can be spread when lesions aren't present

USATODAY.com Health — Fri, 15 Apr 2011 21:38:48 +0100

People with genital herpes can transmit the virus to partners even when they do not have lesions, new research shows. (Source: USATODAY.com Health)

Genital herpes

Clinical Evidence — Fri, 15 Apr 2011 20:32:09 +0100

New evidence; conclusions changed for: Antiviral treatment (oral) versus no treatment for an acute recurrent episode of genital herpes in people with HIV Two RCTs added; categorisation changed from Likely to be beneficial by consensus to Likely to be beneficial (based on RCT evidence). New evidence; conclusion confirmed for: Antiviral maintenance treatment (oral) in late pregnancy (at least 36 weeks' gestation) in women with a history of genital herpes New evidence added. Categorisation unchanged (Unknown effectiveness), as there remains insufficient evidence to judge whether antivirals reduce the rate of transmission of infection because of the rarity of neonatal transmission of herpes simplex virus (HSV) from wome...

Even Without Symptoms, Genital Herpes Can Spread

NPR Health and Science — Fri, 15 Apr 2011 17:00:00 +0100

According to a new study, people who test positive for herpes simplex virus-2 can shed the virus even though they have no symptoms. Infectious disease expert Dr. Peter Leone discusses how herpes is spread and whether people without symptoms should be tested for the virus.» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)

Genital herpes more virulent in Africa than in US, report finds

ScienceDaily Headlines — Fri, 15 Apr 2011 12:31:31 +0100

Strains of genital herpes in Africa are far more virulent than those in the United States, researchers report -- a striking insight into a common disease with important implications for preventing HIV transmission in a region staggered by the HIV/AIDS epidemic. (Source: ScienceDaily Headlines)

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Researchers Seeking A Vaccine Find Genital Herpes More Virulent In Africa Than In US

Health News from Medical News Today — Fri, 15 Apr 2011 08:00:00 +0100

Strains of genital herpes in Africa are far more virulent than those in the United States, researchers at Harvard Medical School report, a striking insight into a common disease with important implications for preventing HIV transmission in a region staggered by the HIV/AIDS epidemic. The researchers arrived at this finding by testing mouse model strains of the disease against vaccine candidates. All vaccines were far more efficacious in abating the U.S. strain... (Source: Health News from Medical News Today)

Genital herpes more virulent in Africa than in US

EurekAlert! - Social and Behavioral Science — Fri, 15 Apr 2011 04:00:00 +0100

(Harvard Medical School) Strains of genital herpes in Africa are far more virulent than those in the United States, researchers at Harvard Medical School report, a striking insight into a common disease with important implications for preventing HIV transmission in a region staggered by the HIV/AIDS epidemic. (Source: EurekAlert! - Social and Behavioral Science)

Persons Without Asymptomatic Genital Herpes Still Shed Virus

Medscape Today Headlines — Wed, 13 Apr 2011 15:52:39 +0100

Although the rate of shedding is lower, people who are HSV2-positive but asymptomatic shed virus on about 10% of days when no lesions are present. Medscape Medical News (Source: Medscape Today Headlines)

Persons With Asymptomatic Genital Herpes Still Shed Virus

Medscape Today Headlines — Wed, 13 Apr 2011 15:52:39 +0100

Genital herpes can spread without symptoms: study

CTV Health — Wed, 13 Apr 2011 14:54:44 +0100

People with genital herpes can still be contagious even when they don't have symptoms or don't realize they have the infection, a new study finds. (Source: CTV Health)

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Dangerous Genital Herpes May Be Hidden, Get Checked!

Health News from Medical News Today — Wed, 13 Apr 2011 09:00:00 +0100

A new Swedish study has found that herpes may be more hidden than previously thought and just not having visual confirmation of the sexually transmitted disease doesn't mean you aren't infected. In the study, just four out of ten patients with genital herpes actually knew that they had the disorder, and a third of those did not realize that they had been infected reported typical symptoms at a follow-up visit... (Source: Health News from Medical News Today)

Genital Herpes' Silent Spread

eMedicineHealth.com — Wed, 13 Apr 2011 07:00:00 +0100

(Source: eMedicineHealth.com)

Genital herpes can spread despite lack of symptoms

Reuters: Health — Tue, 12 Apr 2011 23:47:58 +0100

NEW YORK (Reuters Health) - People with genital herpes can still be contagious even if they don't have symptoms, according to a study that raises the question of whether all adults should be screened for the disease. (Source: Reuters: Health)

Genital Herpes' Silent Spread

WebMD Health — Tue, 12 Apr 2011 21:05:23 +0100

The majority of the 16% of Americans infected with the genital herpes virus don't get noticeable sores -- but 10% of the time, they shed enough virus to infect a sex partner. (Source: WebMD Health)

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Many with herpes type 2 don't know

Health News - UPI.com — Tue, 12 Apr 2011 17:41:46 +0100

GOTHENBURG, Sweden, April 12 (UPI) -- Just four out of 10 patients with genital herpes treated in sexual health clinics in Sweden a may actually know that they had the virus, a researcher says. (Source: Health News - UPI.com)

Genital Herpes Can Be Spread When Lesions Aren't Present

MedlinePlus Health News — Tue, 12 Apr 2011 16:00:00 +0100

Finding confirms suspicions experts have had for years Source: HealthDay Related MedlinePlus Page: Herpes Simplex (Source: MedlinePlus Health News)

Symptom-free herpes still can spread

CNN.com - Health — Tue, 12 Apr 2011 15:44:10 +0100

People who carry the genital herpes virus but have no visible symptoms -- and may not even be aware they're infected -- are still capable of spreading the virus about 10% of the time, according to a new study in the Journal of the American Medical Association. (Source: CNN.com - Health)

Persons with herpes simplex virus type 2, but without symptoms, still shed virus

ScienceDaily Headlines — Tue, 12 Apr 2011 14:13:13 +0100

Persons who have tested positive for herpes simplex virus type 2 (HSV-2) but do not have symptoms or genital lesions still experience virus shedding during subclinical (without clinical manifestations) episodes, suggesting a high risk of transmission from persons with unrecognized HSV-2 infection, according to a new study. (Source: ScienceDaily Headlines)

Persons With Herpes Simplex Virus Type 2, But Without Symptoms, Still Shed Virus

Health News from Medical News Today — Tue, 12 Apr 2011 14:00:00 +0100

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Herpes Can Manifest Itself As Recurring Genital Problems

Health News from Medical News Today — Tue, 12 Apr 2011 14:00:00 +0100

A study of patients attending sexual health clinics in Gothenburg found that just four out of ten patients with genital herpes actually knew that they had the disorder. However, a third of those who did not realise that they had been infected reported typical symptoms at a follow-up visit, reveals a thesis from the University of Gothenburg, Sweden... (Source: Health News from Medical News Today)

Persons with herpes simplex virus type 2, but without symptoms, still shed virus

EurekAlert! - Social and Behavioral Science — Tue, 12 Apr 2011 04:00:00 +0100

(JAMA and Archives Journals) Persons who have tested positive for herpes simplex virus type 2 (HSV-2) but do not have symptoms or genital lesions still experience virus shedding during subclinical (without clinical manifestations) episodes, suggesting a high risk of transmission from persons with unrecognized HSV-2 infection, according to a study in the April 13 issue of JAMA, a theme issue on infectious disease and immunology. (Source: EurekAlert! - Social and Behavioral Science)

Genital Herpes Can Be Spread When Lesions Aren’t Present: Study

The Doctors Lounge - Infections — Mon, 11 Apr 2011 23:00:00 +0100

Finding confirms suspicions experts have had for years (Source: The Doctors Lounge - Infections)

Genital Shedding of Herpes Simplex Virus Among Symptomatic and Asymptomatic Persons With HSV-2 Infection [Original Contribution]

JAMA — Mon, 11 Apr 2011 23:00:00 +0100

Conclusion Persons with asymptomatic HSV-2 infection shed virus in the genital tract less frequently than persons with symptomatic infection, but much of the difference is attributable to less frequent genital lesions because lesions are accompanied by frequent viral shedding. (Source: JAMA)

Herpes simplex virus type 2 infection increases human immunodeficiency virus type 1 entry into human primary macrophages

Virology Journal — Mon, 11 Apr 2011 23:00:00 +0100

Epidemiological and clinical data indicate that genital ulcer disease (GUD) pathogens are associated with an increased risk of human immunodeficiency virus type 1 (HIV-1) acquisition and/or transmission. Among them, genital herpes simplex virus type 2 (HSV-2) seems to play a relevant role. Indeed, the ability of HSV-2 to induce massive infiltration at the genital level of cells which are potential targets for HIV-1 infection may represent one of the mechanisms involved in this process. Here we show that infection of human primary macrophages (MDMs) by HSV-2 results in an increase of CCR5 expression levels on cell surface and allows higher efficiency of MDMs to support entry of R5 HIV-1 strains. This finding could strengthen, at the molecular level, the evidence linking HSV-2 infection to a...

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Increased Genital Shedding in Symptomatic HSV-2 Patients

Modern Medicine — Mon, 11 Apr 2011 23:00:00 +0100

Genital shedding of herpes simplex virus type 2 is less frequent in individuals with asymptomatic infection who also have less frequent genital lesions, according to a study published April 13 in an infectious disease and immunology themed issue of the Journal of the American Medical Association. (Source: Modern Medicine)

HSV Serologic Testing for Pregnant Women: Willingness to Be Tested and Factors Affecting Testing

Computational Intelligence and Neuroscience — Mon, 11 Apr 2011 13:54:13 +0100

Conclusions. These results support the feasibility of HSV serologic testing and counseling in pregnant women. (Source: Computational Intelligence and Neuroscience)

Recurring genital problems could be herpes

EurekAlert! - Social and Behavioral Science — Mon, 11 Apr 2011 04:00:00 +0100

(University of Gothenburg) A study of patients attending sexual health clinics in Gothenburg found that just four out of ten patients with genital herpes actually knew that they had the disorder. However, a third of those who did not realize that they had been infected reported typical symptoms at a follow-up visit, reveals a thesis from the University of Gothenburg, Sweden. (Source: EurekAlert! - Social and Behavioral Science)

New Study Highlights the Importance of Safer Sex

About.com Lymphoma — Thu, 07 Apr 2011 23:00:00 +0100

A study published earlier this month by the Journal of the American Medical Association has revealed that many persons infected with genital herpes (HSV-2) can shed the virus and infect others, even when they have no symptoms present. In addition, the literature indicates that some of these individuals may not even realize they have the infection if there are no symptoms present....Read Full Post (Source: About.com Lymphoma)

Genital Herpes Testing Among Persons Living With HIV

Journal of the Association of Nurses in AIDS Care — Sun, 03 Apr 2011 23:00:00 +0100

This cross-sectional survey explored the frequency of genital herpes testing among 110 people living with HIV (PLWH) and reported barriers and facilitators related to testing. Forty-four percent of the respondents had not been tested for genital herpes since receiving an HIV diagnosis, 34% had been tested, and 22% preferred not to say. Respondents’ most frequently cited factors affecting a decision to not be tested were: (a) testing not being recommended by a provider, (b) not having herpes symptoms, and (c) not thinking they had herpes. Data from this study indicated that PLWH were not frequently tested for genital herpes; there was a limited understanding of the frequently subclinical nature of infection; and provider recommendations for testing, or lack thereof, affected testing decis...

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Safety of antiviral medication for the treatment of herpes during pregnancy.

Canadian Family Physician Medecin de Famille Canadien — Thu, 31 Mar 2011 23:00:00 +0100

Authors: Kang SH, Chua-Gocheco A, Bozzo P, Einarson A Question One of my patients is a pregnant woman in her first trimester with a history of recurrent genital herpes. She is concerned about whether use of her antiviral medication will adversely affect her baby. What should I tell her? Answer Studies have shown that the use of acyclovir or valacyclovir is not associated with an increase in birth defects. Limited data exist for famciclovir and therefore it would not be considered a first-line choice for treatment of herpes during pregnancy. PMID: 21490353 [PubMed - in process] (Source: Canadian Family Physician Medecin de Famille Canadien)

Herpes Simplex Infections (Cold Sores, Non-Genital)

MedicineNet Hearing General — Thu, 24 Mar 2011 07:00:00 +0100

Title: Herpes Simplex Infections (Cold Sores, Non-Genital)Category: Diseases and ConditionsCreated: 6/16/1999 7:38:00 PMLast Editorial Review: 3/24/2011 (Source: MedicineNet Hearing General)

Health-related quality of life in Indian patients with three viral sexually transmitted infections: herpes simplex virus-2, genital human papilloma virus and HIV

Sexually Transmitted Infections — Mon, 21 Mar 2011 00:00:00 +0100

Conclusion Viral STIs were associated with a significant reduction in HRQOL scores. Among patient groups, the greatest impact on HRQOL was seen in those with HIV and mixed infections and the least impact seen in those with genital HPV infection. Comprehensive care including counselling services need to be implemented in STI clinics. (Source: Sexually Transmitted Infections)

A Live-Attenuated HSV-2 ICP0 Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine.

Herpes — Sat, 19 Mar 2011 08:00:06 +0100

Authors: Halford WP, Püschel R, Gershburg E, Wilber A, Gershburg S, Rakowski B Glycoprotein D (gD-2) is the entry receptor of herpes simplex virus 2 (HSV-2), and is the immunogen in the pharmaceutical industry's lead HSV-2 vaccine candidate. Efforts to prevent genital herpes using gD-2 subunit vaccines have been ongoing for 20 years at a cost in excess of $100 million. To date, gD-2 vaccines have yielded equivocal protection in clinical trials. Therefore, using a small animal model, we sought to determine if a live-attenuated HSV-2 ICP0(-) virus would elicit better protection against genital herpes than a gD-2 subunit vaccine. Mice immunized with gD-2 and a potent adjuvant (alum+monophosphoryl lipid A) produced high titers of gD-2 antibody. While gD-2-immunized mice possessed signific...

Viral Linkage in HIV-1 Seroconverters and Their Partners in an HIV-1 Prevention Clinical Trial.

Herpes — Sat, 19 Mar 2011 08:00:06 +0100

CONCLUSIONS/SIGNIFICANCE: In this first use of HIV-1 sequencing to establish endpoints in a large clinical trial, more than one-fourth of transmissions were unlinked to the enrolled partner, illustrating the relevance of these methods in the design of future HIV-1 prevention trials in serodiscordant couples. A hierarchy of sequencing techniques, analysis methods, and expert adjudication contributed to the linkage determination process. PMID: 21399681 [PubMed - as supplied by publisher] (Source: Herpes)

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Correlates of HIV-1 Genital Shedding in Tanzanian Women.

Herpes — Sat, 19 Mar 2011 08:00:06 +0100

We examined correlates of genital HIV-1 RNA in women who were seropositive for both herpes simplex virus (HSV)-2 and HIV-1 and who were enrolled in a randomised controlled trial of HSV suppressive therapy (aciclovir 400 mg b.i.d vs. placebo) in Tanzania. PMID: 21390251 [PubMed - in process] (Source: Herpes)

The prevalence of urogenital microorganisms detected by a multiplex PCR-reverse line blot (mPCR/RLB) assay in women attending three Sydney sexual health clinics.

Journal of Medical Microbiology — Thu, 17 Mar 2011 00:00:00 +0100

Authors: McKechnie ML, Hillman RJ, Jones R, Lowe PC, Couldwell DL, Davies SC, King F, Kong F, Gilbert GL Using a previously described multiplex PCR-based reverse line blot (mPCR/RLB) assay, we studied the prevalence and distribution of 14 urogenital pathogens or putative pathogens - namely; Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, M. hominis, Trichomonas vaginalis, Gardnerella vaginalis, Ureaplasma parvum, U. urealyticum, N. meningitidis, Streptococcus pneumoniae, Haemophilus influenzae, herpes simplex virus (HSV) 1 and 2, and adenovirus. First-voided urine specimens, endocervical and self-collected vaginal swabs, from each of 216 women attending three Sydney sexual health clinics, were tested and results were compared with reference methods for each organis...

Genital Herpes In Women

MedicineNet Hearing General — Wed, 16 Mar 2011 07:00:00 +0100

Title: Genital Herpes In WomenCategory: Diseases and ConditionsCreated: 7/15/1998Last Editorial Review: 3/16/2011 (Source: MedicineNet Hearing General)

Risk Factors for HSV-2 Infection among Sexual Partners of HSV-2/HIV-1 Co-infected Persons

BMC Research Notes — Tue, 15 Mar 2011 00:00:00 +0100

Conclusions: In this cross-sectional analysis of African HIV-1 serodiscordant heterosexual couples with prevalent HSV-2 infection in the HIV-1 infected partner, HIV-1 plasma RNA and CD4 count in the dually-infected partner and male circumcision in the HIV-1 uninfected partner were not associated with HSV-2 concordance.Trial Registration: ClinicalTrials.gov NCT00194519 (Source: BMC Research Notes)

Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection [Medical Sciences]

Proceedings of the National Academy of Sciences — Tue, 15 Mar 2011 00:00:00 +0100

IgG is a major Ig subclass in mucosal secretions of the human female genital tract, where it predominates over the IgA isotype. Despite the abundance of IgG, surprisingly little is known about where and how IgG enters the lumen of the genital tract and the exact role local IgG plays in preventing sexually transmitted diseases. We demonstrate here that the neonatal Fc receptor, FcRn, is expressed in female genital tract epithelial cells of humans and mice and binds IgG in a pH-dependent manner. In vitro we show that FcRn mediates bidirectional IgG transport across polarized human endometrial HEC-1-A monolayers and primary human genital epithelial cells. Furthermore, endosomal acidification appears to be a prerequisite for FcRn-mediated IgG transcytosis; IgG transcytosis was demonstrated in ...

Risk Factors for HSV-2 Infection among Sexual Partners of HSV-2/HIV-1 Co-infected Persons.

Herpes — Tue, 15 Mar 2011 00:00:00 +0100

CONCLUSIONS: In this cross-sectional analysis of African HIV-1 serodiscordant heterosexual couples with prevalent HSV-2 infection in the HIV-1 infected partner, HIV-1 plasma RNA and CD4 count in the dually-infected partner and male circumcision in the HIV-1 uninfected partner were not associated with HSV-2 concordance. Trial Registration: ClinicalTrials.gov NCT00194519. PMID: 21406077 [PubMed - as supplied by publisher] (Source: Herpes)

Rapid clearance of herpes simplex virus type 2 by CD8+ T cells requires high level expression of effector T cell functions

Journal of Reproductive Immunology — Mon, 14 Mar 2011 00:00:00 +0100

Abstract: CD8+ T cells are important for resolution of HSV-2 lesions from the female genital epithelium. It is uncertain whether optimal clearance of viruses such as HSV-2 that cause a limited, non-systemic infection solely requires expression of effector functions by infiltrating CD8+ T lymphocytes, or if the clearance rate is reflective of the expression level of critical effector functions. To address this, CD8+ T cells from normal OT-I mice or OT-I mice deficient in IFNγ (IFNγ−/−) or the IFNγ receptor (IFNγR−/−) were activated in vitro in the presence of IFNγ or IL-4 to generate a series of effector populations (Tc1 and Tc2-like respectively) that secreted different levels of IFNγ and expressed different levels of HSV-specific cytolytic function. Compared with Tc1 cells, ...

Aetiology of sexually transmitted infections in Maputo, Mozambique.

Herpes — Sat, 05 Mar 2011 00:15:50 +0100

Authors: Zimba TF, Apalata T, Sturm WA, Moodley P The study sought to ascertain the prevalence of the aetiological agents of genital discharge and genital ulcer diseases in Maputo, Mozambique. PMID: 21330739 [PubMed - in process] (Source: Herpes)

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CROI: Circumcision Protects Against Genital Ulcers (CME/CE)

MedPage Today Infectious Disease — Thu, 03 Mar 2011 19:30:30 +0100

BOSTON (MedPage Today) -- Male circumcision cuts the risk of genital ulcer disease, but not herpes simplex-2, a researcher said here. (Source: MedPage Today Infectious Disease)

Valacyclovir Plus Zidovudine May Block Vertical Transmission of HSV-2

Medscape Nurses Headlines — Thu, 03 Mar 2011 17:45:24 +0100

Valacyclovir cut HIV-1 RNA levels and herpes simplex virus (HSV)-2 genital shedding in a study of pregnant women receiving zidovudine. Medscape Medical News (Source: Medscape Nurses Headlines)

Survey of Diagnostic Services for Genital Herpes in Fourteen Countries in Eastern Europe.

Herpes — Thu, 03 Mar 2011 00:00:00 +0100

Authors: Domeika M, Babayan K, Ismailov R, Shimanskaya I, Chudomirova K, Brilene T, Kvlividze O, Deak J, Askarova G, Mamajeva G, Kucinskiene V, Frigo N, Savicheva A, Krasnoselskich T, Mavrov G, Kasymov O, Izvekova O, Unemo M, Ballard RC This paper reports survey-based data on the diagnosis and management of genital herpes simplex virus (HSV) infection in 14 countries of the Eastern European Network for Sexual and Reproductive Health (EE SRH). Only 43% of the countries could provide the number of genital HSV cases recorded at national level. Eighty-six percent of countries employed syndromic management in cases of genital ulcer disease. Most countries performed type-specific and/or non-type-specific enzyme immunoassays to detect HSV antibodies. Non-type-specific serology for diagnostic ...

European guideline for the management of genital herpes, 2010

International Journal of STD and AIDS — Tue, 01 Mar 2011 00:00:00 +0100

This is the guideline for genital herpes simplex virus (HSV) management for the IUSTI/WHO Europe, 2010. They describe the epidemiology, diagnosis, clinical features, treatment and prevention of genital HSV infection. They include details on the management of HSV in pregnancy, those who are immunocompromised and the clinical investigation and management of suspected HSV-resistant disease. (Source: International Journal of STD and AIDS)