MedWorm: Genital Warts

A large, population-based study of age-related associations between vaginal pH and human papillomavirus infection

BMC Infectious Diseases — Wed, 08 Feb 2012 05:00:00 +0100

We examined vaginal pH and the risk of HPV infection, cytological abnormalities, and C. trachomatis infection. Methods: Our study included 9,165 women aged 18-97 at enrollment with a total of 28,915 visits (mean length of follow-up = 3.4 years). Generalized estimating equations were used to evaluate the relationship between vaginal pH and HPV infection (both overall and single versus multiple types) and low-grade squamous intraepithelial lesions (LSIL), the cytomorphic manifestation of HPV infection. The relationship between enrollment vaginal pH and C. trachomatis infection was assessed by logistic regression. Results were stratified by age at visit. Results: Detection of HPV was positively associated with vaginal pH, mainly in women (Source: BMC Infectious Diseases)

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Pooled Analysis of a Self-Sampling HPV DNA Test as a Cervical Cancer Primary Screening Method

JNCI — Tue, 07 Feb 2012 05:00:00 +0100

Conclusions The sensitivity of Self-HPV testing compared favorably with that of LBC and was superior to the sensitivity of VIA. Self-HPV testing may complement current screening programs by increasing population coverage in settings that do not have easy access to comprehensive cytology-based screening. (Source: JNCI)

Recommendations on the Use of Quadrivalent Human Papillomavirus Vaccine in Males--Advisory Committee on Immunization Practices (ACIP), 2011 [From the Centers for Disease Control and Prevention]

JAMA — Tue, 07 Feb 2012 05:00:00 +0100

(Source: JAMA)

Human Papillomavirus Vaccination Practices Among Providers in Indian Health Service, Tribal and Urban Indian Healthcare Facilities

Journal of Women — Mon, 06 Feb 2012 21:47:50 +0100

Journal of Women's Health , Vol. 0, No. 0. (Source: Journal of Women)

Five Years After HPV Vaccine Law, Virginia Remains Split

Drugs.com - Pharma News — Mon, 06 Feb 2012 13:02:59 +0100

Five Years After HPV Vaccine Law, State Remains Split [Virginian - Pilot] From Virginian - Pilot (February 5, 2012) By Elizabeth Simpson | The Virginian-Pilot Tonya McKinney was so intent on her daughter receiving the human papillomavirus... (Source: Drugs.com - Pharma News)

US Pediatricians Recommend Routine HPV Vaccination For Boys

Health News from Medical News Today — Fri, 03 Feb 2012 20:00:00 +0100

As part of a revised standard published this week, the American Academy of Pediatrics says boys should be routinely vaccinated against the human papillomavirus (HPV), a common virus that is spread through sexual contact. Although there are dozens of types of HPV, vaccines can protect both male and females against some of the more common types that can lead to disease and cancer... (Source: Health News from Medical News Today)

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National Briefing | Health: Officials Recommend the HPV Vaccine for All Boys

NYT — Fri, 03 Feb 2012 19:20:07 +0100

Federal health officials recommended on Thursday that all boys be routinely vaccinated against infection with human papillomavirus, or HPV. (Source: NYT)

HPV vaccine now recommended for all boys, CDC says

Health News: CBSNews.com — Fri, 03 Feb 2012 19:18:30 +0100

At least 50 percent of sexually active men and women get will get infected with human papillomavirus at some point, according to CDC (Source: Health News: CBSNews.com)

Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16‐positive women: a clinical trial using dynamic spectral imaging colposcopy

BJOG: An International Journal of Obstetrics and Gynaecology — Fri, 03 Feb 2012 05:00:00 +0100

Conclusions The sensitivity of DSI colposcopy for CIN2+ is higher in HPV16+ than in non‐16 hrHPV+ women. Furthermore, regardless of HPV16 status, the sensitivity of DSI for CIN2+ is higher than that of the colposcopist, probably because colposcopists tend to miss smaller cervical lesions. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)

Well: HPV Vaccine Now Recommended for Boys, Hepatitis B Vaccine for Diabetes

NYT Health — Fri, 03 Feb 2012 03:29:32 +0100

Federal health officials recommended this week that all boys be routinely vaccinated against human papillomavirus, or HPV, and that people with diabetes be vaccinated against hepatitis B. (Source: NYT Health)

National Briefing | Health: Officials Recommend the HPV Vaccine for All Boys

NYT Health — Fri, 03 Feb 2012 01:10:05 +0100

Federal health officials recommended on Thursday that all boys be routinely vaccinated against infection with human papillomavirus, or HPV. (Source: NYT Health)

Human papillomavirus detected in esophageal squamous cell carcinoma in Iran.

European Journal of Internal Medicine — Fri, 03 Feb 2012 00:25:02 +0100

CONCLUSION: In conclusion, the present study showed that a small proportion of ESCC specimens from Iran harbor HPV16, 18 genome using a highly sensitive method. As different rates have been reported from Iran, a more widespread study with more precise definition of geographical differences could delineate the potential involvement of HPV in the development of ESCC in Iranian population. PMID: 22284258 [PubMed - in process] (Source: European Journal of Internal Medicine)

Emerging Sexual Health Issues Among Women Who Have Sex with Women

Current Infectious Disease Reports — Thu, 02 Feb 2012 18:14:13 +0100

Abstract Women who have sex with women (WSW) comprise a diverse group of people who evidence a spectrum of sexual identity, sexual behaviors, sexual practices, and risk behaviors. WSW are at risk of acquiring a diversity of sexually transmitted infections (STIs) from current and prior partners, both male and female. Notably, human papillomavirus (HPV) is sexually transmitted between female partners, and Pap smear guidelines should be followed in this group. Bacterial vaginosis is common among WSW. WSW should not be presumed to be at low or no risk for STIs based on sexual orientation, and reporting of same sex behavior by women should not deter providers from considering and performing screening for STIs, including Chlamydia trachomatis, according to current guidelines. Eff...

Well Blog: HPV Vaccine Now Recommended for Boys, Hepatitis B Vaccine for Diabetes

NYT Health — Thu, 02 Feb 2012 16:59:25 +0100

HPV vaccines (Gardasil) now pushed onto boys in Canada

NaturalNews.com — Thu, 02 Feb 2012 06:00:00 +0100

There is still a whole lot of money to be made from pushing human papillomavirus (HPV) vaccines on young people around the world. But in order to accomplish this, the market for the vaccines, which include Merck & Co.'s Gardasil and GlaxoSmithKline's Cervarix, must be... (Source: NaturalNews.com)

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HPV vaccine recommended for boys

Health Facts and Fears — Thu, 02 Feb 2012 05:00:00 +0100

Both the Centers for Disease Control and Prevention and the American Academy of Pediatrics are now advising parents to vaccinate their boys against the human papillomavirus (HPV), especially before they become sexually active. (Source: Health Facts and Fears)

Oral HPV infection linked with sexual behavior

MedWire News - Oncology — Thu, 02 Feb 2012 00:00:00 +0100

Detailed information on the epidemiology of oral human papillomavirus infection in the United States has been published, showing that the prevalence is around 7% in the general population, but as high as 45% in certain high-risk subgroups. (Source: MedWire News - Oncology)

[Correspondence] Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine

The Lancet Oncology — Wed, 01 Feb 2012 05:00:00 +0100

The 4-year end-of-study analysis of the PATRICIA trial published in The Lancet Oncology adds to findings of previous interim analyses. In this trial, Lehtinen and colleagues assessed the efficacy of a bivalent human papillomavirus (HPV) vaccine, administered to 18 644 healthy women aged 15–25 years, for reduction of high-grade cervical intraepithelial neoplasia (CIN3+). (Source: The Lancet Oncology)

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Unilateral neck therapy in the human papillomavirus ERA: Accepted regional spread patterns

Head and Neck — Wed, 01 Feb 2012 05:00:00 +0100

ConclusionIn the human papillomavirus (HPV) era, bilateral neck disease is increasingly common. This seems to be a consequence of the increasing incidence of tonsillar cancer rather than a new biologic behavior. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)

HPV Vaccine Policy: At Odds With Evidence-Based Medicine?HPV Vaccine Policy: At Odds With Evidence-Based Medicine?

Medscape Today Headlines — Tue, 31 Jan 2012 16:30:50 +0100

According to a new study, there is a major discrepancy in claims regarding the safety and efficacy of the human papillomavirus (HPV) vaccines. Medscape Medical News (Source: Medscape Today Headlines)

Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses [Microbiology]

Proceedings of the National Academy of Sciences — Tue, 31 Jan 2012 05:00:00 +0100

More than 120 human papillomaviruses (HPVs) have now been identified and have been associated with a variety of clinical lesions. To understand the molecular differences among these viruses that result in lesions with distinct pathologies, we have begun a MS-based proteomic analysis of HPV–host cellular protein interactions and have created the plasmid and cell line libraries required for these studies. To validate our system, we have characterized the host cellular proteins that bind to the E7 proteins expressed from 17 different HPV types. These studies reveal a number of interactions, some of which are conserved across HPV types and others that are unique to a single HPV species or HPV genus. Binding of E7 to UBR4/p600 is conserved across all virus types, whereas the cellular protein ...

QnAs with Harald zur Hausen [QnAs]

Proceedings of the National Academy of Sciences — Tue, 31 Jan 2012 05:00:00 +0100

The first carcinogenic virus was discovered in chickens in 1911. More than 70 years later, Harald zur Hausen demonstrated that human papillomavirus (HPV) can cause cervical cancer, for which he garnered the 2008 Nobel Prize in Medicine or Physiology. A professor emeritus at the German Cancer Research Center and recently elected member of the National Academy of Sciences, zur Hausen’s contributions to the field of virology have reshaped our understanding of the connections between infectious and chronic diseases. PNAS recently spoke with the Nobel laureate about HPV, undercooked beef, and scientific “dogma.”pnas;109/5/1378/UNFIG01F1unfig01Harald zur Hausen.PNAS:In general, how do viruses cause cancer?zur... (Source: Proceedings of the National Academy of Sciences)

About 7 percent of U.S. has oral HPV

Health News - UPI.com — Tue, 31 Jan 2012 00:54:37 +0100

COLUMBUS, Ohio, Jan. 30 (UPI) -- About 7 percent of U.S. men and women ages 14-69 have oral human papillomavirus, but the prevalence is higher among men, researchers said. (Source: Health News - UPI.com)

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Oral HPV Rates Higher In Men Than Women

Health News from Medical News Today — Mon, 30 Jan 2012 18:00:00 +0100

A study published in JAMA reveals that among men and women between the ages 14 to 69 years in the U.S., the overall prevalence of oral human papillomavirus (HPV) infection is around 7%. In addition, the researchers found that the prevalence of HPV is higher among men than women. The study is being published early online in order to accompany its presentation at the Multidisciplinary Head and Neck Cancer Symposium. The researchers explain: "Oral HPV infection is the cause of a subset of oropharyngeal [relating to the mouth and pharynx] squamous cell carcinomas (OSCC)... (Source: Health News from Medical News Today)

'Oral cancer risk' in men as HPV rates higher

NHS News Feed — Mon, 30 Jan 2012 09:57:00 +0100

Conclusion This was a relatively large cross-sectional study that estimated the number of oral HPV infections in the US among 14 to 69 year olds. These estimates cannot be directly generalised to the UK. The researchers say that their data provide evidence that oral HPV infection is mainly sexually transmitted. This is because infection was uncommon among participants with no previous sexual partners, but was up to eight times higher among those with previous partners, and increased significantly as the number of partners increased. The researchers do point out, however, that their study did not collect information on possible non-sexual transmission methods. While policy decisions regarding HPV infection generally focus on genital HPV among females, this research demonstrated that, at lea...

Knowledge, attitude and practice in primary and secondary cervical cancer prevention among young adult Italian women.

Vaccine — Mon, 30 Jan 2012 05:00:00 +0100

Authors: Donati S, Giambi C, Declich S, Salmaso S, Filia A, Atti ML, Alibrandi MP, Brezzi S, Carozzi F, Collina N, Franchi D, Lattanzi A, Meda M, Minna MC, Nannini R, Gallicchio G, Bella A, Abstract In Italy since 2007 vaccination against human papillomavirus (HPV) is offered to 11-year-old females, whereas vaccination for older age groups is still a matter of debate. To assess Italian young women's knowledge, attitudes and practice regarding primary and secondary cervical cancer prevention a cross-sectional study among young women aged 18-26 years was conducted in 2008. The survey collected information on in-depth awareness and knowledge regarding Pap testing, HPV infection, HPV vaccine and cervical cancer. The response rate was 57.7% with a wide range of variability (34-84%) amo...

HPV Vaccine Not Linked To Autoimmune Disorders, Study

Health News from Medical News Today — Sun, 29 Jan 2012 00:00:00 +0100

A two-year study of nearly 190,000 girls and women, finds that Gardasil, the human papillomavirus (HPV) vaccine made by Merck & Co, does not trigger autoimmune disorders such as lupus, rheumatoid arthritis, type 1 diabetes and multiple sclerosis. The results are published in the Journal of Internal Medicine. Study lead author Dr Chun Chao, a research scientist at the Kaiser Permanente Department of Research & Evaluation in Pasadena, California, said in a statement released on Friday, that: "This kind of safety information may help parents with vaccination decisions... (Source: Health News from Medical News Today)

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No Increase in Autoimmune Conditions From Use of HPV VaccineNo Increase in Autoimmune Conditions From Use of HPV Vaccine

Medscape Today Headlines — Fri, 27 Jan 2012 23:31:42 +0100

In a large population of young women aged 9 to 26 years receiving quadrivalent human papillomavirus vaccine, researchers found no increase in new-onset cases for 16 autoimmune conditions surveyed. Medscape Medical News (Source: Medscape Today Headlines)

Study: No link between HPV vaccine and autoimmune disorders

USATODAY.com Health — Fri, 27 Jan 2012 21:30:42 +0100

The human papillomavirus (HPV) vaccine Gardasil does not trigger autoimmune disorders according to a new study. (Source: USATODAY.com Health)

Oral HPV Infection: Higher in Men, Transmitted by SexOral HPV Infection: Higher in Men, Transmitted by Sex

Medscape Today Headlines — Fri, 27 Jan 2012 13:43:46 +0100

A much higher incidence of human papillomavirus (HPV) in men than women raises the question of whether boys should be getting the HPV vaccine in addition to girls. Medscape Medical News (Source: Medscape Today Headlines)

Men At Greater Risk For Oral HPV Infection, HPV-Related Cancers

Health News from Medical News Today — Fri, 27 Jan 2012 12:00:00 +0100

Oral HPV infection is more common among men than women, explaining why men are more prone than women to develop an HPV related head and neck cancer, according to a study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM. Human papillomavirus, or HPV, has recently been linked to some types of head and neck cancer that are becoming more prominent in the United States, mostly among men... (Source: Health News from Medical News Today)

2-Year Study Finds Gardasil Does Not Trigger Autoimmune Conditions After Vaccination

Health News from Medical News Today — Fri, 27 Jan 2012 08:00:00 +0100

Gardasil, the human papillomavirus vaccine that is now recommended for male and female adolescents and young adults, does not trigger autoimmune conditions such as lupus, rheumatoid arthritis, type 1 diabetes or multiple sclerosis after vaccination in young women, according to a new study in the Journal of Internal Medicine. Kaiser Permanente researchers used electronic health records to conduct an observational safety study of 189,629 females aged 9 to 26 years old in California who were followed for six months after receiving each dose of the quadrivalent HPV vaccine in 2006-2008... (Source: Health News from Medical News Today)

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HPV study finds 7% of U.S. teens, adults carry virus in mouths

Los Angeles Times - Science — Fri, 27 Jan 2012 08:00:00 +0100

Infection with human papillomavirus heightens the risk of developing cancer of the mouth and throat. The findings indicate that most cases of oral HPV can be traced to oral sex, rather than to kissing or casual contact.A new study showing an estimated 7% of American teens and adults carry the human papillomavirus in their mouths may help health experts finally understand why rates of mouth and throat cancer have been climbing for nearly 25 years. The evidence makes it clear that oral sex practices play a key role in transmission. (Source: Los Angeles Times - Science)

inducTION of mage‐A3 and HPV‐16 immunity by Trojan vaccines in patients with head and neck carcinoma

Head and Neck — Fri, 27 Jan 2012 05:00:00 +0100

ConclusionThis treatment regimen seems to have acceptable toxicity and elicits measurable systemic immune responses against HLA‐II restricted epitopes in a subset of patients with advanced SCCHN. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)

Oral Cancer: Another target ripe for HPV vaccine

Health Facts and Fears — Fri, 27 Jan 2012 05:00:00 +0100

Oropharyngeal cancer, which affects the throat, tongue, soft palate, and tonsils, has become increasingly common among men in the U.S. Because a distinct form of it is caused primarily by HPV (human papillomavirus), a recent study set out to determine the prevalence of oral HPV infection. attack. (Source: Health Facts and Fears)

Study: 1 in 4 People Has Oral HPV Infection

RWJF News Digest - Public Health — Fri, 27 Jan 2012 05:00:00 +0100

So how many people have human papillomavirus in their mouths? Quite a few, say researchers who got more than 5,000 volunteers across the country to spit into a cup and answer detailed questions about their sex lives. (Source: RWJF News Digest - Public Health)

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More men 'have oral cancer virus'

BBC News | Health | UK Edition — Fri, 27 Jan 2012 01:27:16 +0100

Oral human papillomavirus (HPV) infection is more common among men than women, leading to an increased risk for men of head and neck cancers, a US study suggests. (Source: BBC News | Health | UK Edition)

[Correspondence] Genital HPV types in Australia

The Lancet Infectious Diseases — Thu, 26 Jan 2012 23:05:13 +0100

We were intrigued by Edoardo Tartaglia and colleagues' use of a small sample of human papillomavirus (HPV) typing data of unknown representativeness to scrutinise the decline in genital warts reported in Australia after HPV vaccination. They suggest that the decline could be less than anticipated by international data because genital warts in Australia might be caused predominantly by non-HPV vaccine types, implying that the cause of genital warts in Australia could be different to that in every other country studied. (Source: The Lancet Infectious Diseases)

The Interplay of Age Stratification and HPV Testing on the Predictive Value of ASC-US Cytology: Results From the ATHENA HPV Study.

American Journal of Clinical Pathology — Thu, 26 Jan 2012 22:54:44 +0100

Authors: Stoler MH, Wright TC, Sharma A, Zhang G, Apple R, Wright TL, Behrens CM, Abstract We have previously shown that human papillomavirus (HPV) genotyping, using the cobas HPV Test (Roche Molecular Systems, Pleasanton, CA), can be used to identify women with atypical squamous cells of undetermined significance (ASC-US) at the highest risk for cervical intraepithelial neoplasia (CIN) grade 2 or worse. We investigated the impact of age stratification on the risk of CIN 2 or worse in women with ASC-US and the performance of HPV genotyping in different age strata. The sensitivity of the cobas HPV Test was 93.3% in the 21- to 29-year-old age group and 67.7% in the 40 years or older group, most likely owing to pathologic misclassification of CIN 2 or worse in older women. The preval...

Well: Oral HPV More Common in Men Than Women

NYT — Thu, 26 Jan 2012 19:30:23 +0100

About one in 15 Americans is infected with oral human papillomavirus, a sexually transmitted virus that causes throat cancers, and the disease is especially common among men, new research shows. (Source: NYT)

Vital Signs: Patterns: Oral HPV More Common in Men Than Women

NYT Health — Thu, 26 Jan 2012 19:30:23 +0100

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Vital Signs: Risks: Oral HPV More Common in Men Than Women

NYT Health — Thu, 26 Jan 2012 19:30:23 +0100

Oral HPV-Cancer Link Clarified (CME/CE)

MedPage Today Hematology/Oncology — Thu, 26 Jan 2012 19:30:00 +0100

PHOENIX (MedPage Today) -- Oral infection with human papillomavirus occurred three times more often in men as in women, a potential explanation for men's higher rate of HPV-related head and neck cancer, investigators reported here. (Source: MedPage Today Hematology/Oncology)

Oral HPV infection increasing in young men

AuntMinnie.com Headlines — Thu, 26 Jan 2012 18:45:18 +0100

The incidence of oral human papillomavirus (HPV) infection, the principal cause (more) (Source: AuntMinnie.com Headlines)

7% Of Americans Have Oral HPV

Health News from Medical News Today — Thu, 26 Jan 2012 17:00:00 +0100

A study published online in JAMA on Thursday suggests 7% of men and women in the US carry the Human papillomavirus (HPV), the virus that causes a distinct form of cancer that affects the part of the throat that sits at the back of the mouth. The study suggests oral HPV infection is predominantly sexually transmitted, and estimates that men are nearly three times more likely to have the virus than women. Maura L. Gillison, Professor in the College of Medicine at Ohio State University (OSU), and others carried out the study... (Source: Health News from Medical News Today)

Self-HPV Testing Could Be An Effective Cervical Cancer Screening Method

Health News from Medical News Today — Thu, 26 Jan 2012 17:00:00 +0100

A study published January 23 in the Journal of the National Cancer Institute , has found that self-HPV (human papillomavirus) testing, in low-resource settings, may be a more effective way to screen for cervical cancer than liquid-based cytology (LBC) and visual inspection with acetic acid (VIA). Cervical cancer is one of the most prevalent cancers found in women. Each year, around 530,000 women are diagnosed with the disease, resulting in an estimated 275,000 deaths... (Source: Health News from Medical News Today)

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Well: Oral HPV More Common in Men Than Women

NYT Health — Thu, 26 Jan 2012 15:49:41 +0100

Indications Of A Benefit In Primary HPV Testing

Health News from Medical News Today — Thu, 26 Jan 2012 08:00:00 +0100

Precursors of cervical cancer can be detected and treated earlier / Risk of over-treatment Studies currently available provide indications and a "hint" that precursors of cervical cancer can be detected and treated earlier, and consequently tumours occur less often, in women who underwent testing for human papillomavirus (HPV). In this context, an HPV test can be used alone or in addition to a Papanicolaou test (Pap smear). However, both screening procedures also carry a risk of harm in the form of unnecessary treatments after testing (over-treatment)... (Source: Health News from Medical News Today)

Prevalence of oral HPV infection higher among men than women

EurekAlert! - Social and Behavioral Science — Thu, 26 Jan 2012 05:00:00 +0100

(JAMA and Archives Journals) The overall prevalence of oral human papillomavirus (HPV) infection is approximately 7 percent among men and women ages 14 to 69 years in the United States, while the prevalence among men is higher than among women, according to a study appearing in JAMA. The study is being released early online to coincide with its presentation at the Multidisciplinary Head and Neck Cancer Symposium. (Source: EurekAlert! - Social and Behavioral Science)

Prediction of cervical intraepithelial neoplasia grade 2+ (CIN2+) using HPV DNA testing after a diagnosis of atypical squamous cells of undetermined significance (ASC-US) in Catalonia, Spain.

BMC Infectious Diseases — Thu, 26 Jan 2012 05:00:00 +0100

Conclusions: Triage of ASC-US with hrHPV testing showed a high sensitivity for the detection of CIN2+ and a high negative predictive value after 3 years of follow-up. The results of this study are in line with the current guidelines for triage of women with ASC-US in the target age range of 25-65. Non adherence to guidelines will lead to unnecessary medical interventions. Further investigation is needed to improve specificity of ASC-US triage. (Source: BMC Infectious Diseases)

Exploring biomarkers in head and neck cancer

Cancer — Thu, 26 Jan 2012 05:00:00 +0100

AbstractPersonalized medicine based on predictive markers linked to drug response, it is hoped, will lead to improvements in outcomes and avoidance of unnecessary treatment in squamous cell carcinoma of the head and neck (SCCHN). Recent research has shown that expression of ERCC1 may predict resistance to treatment with platinum agents. Future testing for this marker may help select the optimal type of chemotherapy. Infection with human papillomavirus (HPV) is associated with less aggressive disease and better prognosis in locally advanced SCCHN treated with chemoradiation or radiation alone; HPV‐positive patients may ultimately benefit from less intensive, less toxic therapy. K‐RAS mutations, occurring in about 40% of colorectal cancers and associated with lack of benefit from epiderm...

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Oral Human Papillomavirus Infection: Hazard of Intimacy [Editorial]

JAMA — Thu, 26 Jan 2012 05:00:00 +0100

(Source: JAMA)

Prevalence of Oral HPV Infection in the United States, 2009-2010 [Original Contribution]

JAMA — Thu, 26 Jan 2012 05:00:00 +0100

Conclusion Among men and women aged 14 to 69 years in the United States, the overall prevalence of oral HPV infection was 6.9%, and the prevalence was higher among men than among women. (Source: JAMA)

Cellular transformation by human papillomaviruses: Lessons learned by comparing high- and low-risk viruses.

Virology — Thu, 26 Jan 2012 05:00:00 +0100

Authors: Klingelhutz AJ, Roman A Abstract The oncogenic potential of papillomaviruses (PVs) has been appreciated since the 1930s yet the mechanisms of virally-mediated cellular transformation are still being revealed. Reasons for this include: a) the oncoproteins are multifunctional, b) there is an ever-growing list of cellular interacting proteins, c) more than one cellular protein may bind to a given region of the oncoprotein, and d) there is only limited information on the proteins encoded by the corresponding non-oncogenic PVs. The perspective of this review will be to contrast the activities of the viral E6 and E7 proteins encoded by the oncogenic human PVs (termed high-risk HPVs) to those encoded by their non-oncogenic counterparts (termed low-risk HPVs) in an attempt to sort...

Oral HPV infections more common than expected

USATODAY.com Health — Thu, 26 Jan 2012 02:32:11 +0100

The human papillomavirus appears to be mostly spread through sex, rather than more casual contact such as kissing, a study finds. (Source: USATODAY.com Health)

Do-It-Yourself HPV TestHelps Screen for Cervical Cancer (CME/CE)

MedPage Today Public Health — Wed, 25 Jan 2012 16:35:37 +0100

(MedPage Today) -- Patient-collected specimens for human papillomavirus DNA testing detected precancerous cervical lesions with accuracy comparable to that of cytology-based Pap screening and visual inspection, data from screening studies showed. (Source: MedPage Today Public Health)

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Do-It-Yourself HPV Test Helps Screen for Cervical Cancer (CME/CE)

MedPage Today Hematology/Oncology — Wed, 25 Jan 2012 16:35:37 +0100

Kaiser Permanente study finds Gardasil does not trigger autoimmune conditions after vaccination

EurekAlert! - Medicine and Health — Wed, 25 Jan 2012 05:00:00 +0100

(Kaiser Permanente) Gardasil, the human papillomavirus vaccine that is now recommended for male and female adolescents and young adults, does not trigger autoimmune conditions such as lupus, rheumatoid arthritis, Type 1 diabetes or multiple sclerosis after vaccination in young women, according to a new study in the Journal of Internal Medicine. (Source: EurekAlert! - Medicine and Health)

Adjunctive testing for cervical cancer screening in low resource settings

The Australian and New Zealand Journal of Obstetrics and Gynaecology — Wed, 25 Jan 2012 05:00:00 +0100

ConclusionsSequential testing combination of VIA and HPV, followed by colposcopy and directed biopsy for diagnosis, combines economic viability with high scientific fidelity. The high specificity and negative predictive value reduce referral and treatment rates, as well as number of visits required for diagnosis. HPV (P) followed by reflex Pap is a suitable option for high resource situations with access to liquid‐based cytology. (Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology)

Human Papillomavirus antibody reference reagents for post-vaccine surveillance serology.

Clinical and Vaccine Immunology — Wed, 25 Jan 2012 05:00:00 +0100

Authors: Bissett SL, Wilkinson D, Tettmar KI, Jones N, Stanford E, Panicker G, Faust H, Borrow R, Soldan K, Unger ER, Dillner J, Minor P, Beddows S Abstract Suitably-controlled sero-surveillance surveys are essential for evaluating Human Papillomavirus (HPV) immunization programmes. A panel of plasma samples from 18 year old females was assembled, the majority being from bivalent vaccinees. Antibody specificities were evaluated by three independent laboratories and 3 pools were created that displayed either no antibodies to any HPV type tested, intermediate or high antibody levels to HPV16, HPV18, HPV31 and HPV45. These pools will be useful as control reagents for HPV serology. PMID: 22278326 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)

Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization.

Virology — Wed, 25 Jan 2012 05:00:00 +0100

Authors: Vandermark ER, Deluca KA, Gardner CR, Marker DF, Schreiner CN, Strickland DA, Wilton KM, Mondal S, Woodworth CD Abstract The NF-kB family of transcription factors regulates important biological functions including cell growth, survival and the immune response. We found that Human Papillomavirus type 16 (HPV-16) E7 and E6/E7 proteins inhibited basal and TNF-alpha-inducible NF-kB activity in human epithelial cells cultured from the cervical transformation zone, the anatomic region where most cervical cancers develop. In contrast, HPV-16 E6 regulated NF-kB in a cell type- and cell growth-dependent manner. NF-kB influenced immortalization of cervical cells by HPV16. Inhibition of NF-kB by an IkB alpha repressor mutant increased colony formation and immortalization by HPV-16. I...

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Sexual Health Knowledge of Male and Female Latino Immigrants

Journal of Immigrant and Minority Health — Tue, 24 Jan 2012 18:13:14 +0100

Abstract To explore sexual health knowledge among Latino immigrants in a Southern U.S. city, we conducted 20 qualitative interviews, (10 Women and 10 Men). We explored knowledge and factors associated with sexual health among male and female Latino immigrants in a Southern U.S. city experiencing a major growth of Latino immigrants in the past 10 years. Both genders demonstrated limited knowledge of Human Papillomavirus (HPV) and risks of sexually transmitted infection (STI) acquisition. Neither gender perceived that they could have an asymptomatic STI, including HPV. Gender differences exist in sexual behaviors and perceptions of STI risk. Females indicated that female Latinas tend to have older sexual initiation age, fewer lifetime sexual partners and more pro-active...

Cervical Cancer Screening Via Self-Collection

Health News from Medical News Today — Tue, 24 Jan 2012 10:00:00 +0100

Human papillomavirus (HPV) testing of self-collected specimens may be a more effective way to screen for cervical cancer in low-resource settings compared to visual inspection with acetic acid (VIA) and liquid-based cytology (LBC), according to a study published in the Journal of the National Cancer Institute. Cervical cancer is the third most common cancer found in women with approximately 530,000 new cases each year resulting in an estimated 275,000 deaths... (Source: Health News from Medical News Today)

Brg1 regulates the transcription of human papillomavirus type 18 E6 and E7 genes.

Cell Cycle — Tue, 24 Jan 2012 09:50:44 +0100

Authors: He H, Luo Y Abstract Integrated high-risk human papillomavirus (HPV) DNA was frequently detected in the genomes of cervical carcinoma cells. The HPV E6 and E7 oncoproteins disrupt the functions of tumor suppressors p53 and Rb; thus, understanding the mechanism by which HPV E6 and E7 gene expression is regulated in cancer cells is highly relevant to cancer biology. Brg1 is a catalytic subunit of the SWI/SNF chromatin remodeling complexes that function in the transcriptional regulation of certain cellular genes. Here, we show that knockdown of Brg1 in HeLa cells leads to cell cycle arrest, p53 and Rb protein accumulation and, interestingly, downregulated expression of HPV18 E6 and E7 genes. Brg1 binds the HPV18 LCR in a JunB- and p300-dependent manner and is required for eff...

HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia

BMC Cancer — Tue, 24 Jan 2012 05:00:00 +0100

Background: The development of cervical cancer and its high-grade precursor lesions (Cervical Intraepithelial Neoplasia grade 2/3 [CIN2/3]) result from a persistent infection with high-risk human papillomavirus (hrHPV) types and the accumulation of (epi)genetic host cell aberrations. Epidemiological studies have demonstrated variable CIN2/3 and cancer risks between different hrHPV types. Recent genomic profiling studies revealed substantial heterogeneity in the chromosomal aberrations detected in morphologically indistinguishable CIN2/3 suggestive of varying cancer risk. The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected. Methods: Chromosom...

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

Dermatology — Mon, 23 Jan 2012 17:39:42 +0100

Dermatology (DOI:10.1159/000335371) (Source: Dermatology)

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Electrochemical genosensor array for the simultaneous detection of multiple high-risk human papillomavirus sequences in clinical samples.

Analytica Chimica Acta — Mon, 23 Jan 2012 01:12:41 +0100

Authors: Civit L, Fragoso A, Hölters S, Dürst M, O'Sullivan CK Abstract An electrochemical genosensor array for the simultaneous detection of three high-risk human papillomavirus (HPV) DNA sequences, HPV16, 18 and 45, exhibiting high sensitivity and selectivity is presented. The electrodes of a 4×4 array were modified via co-immobilization of a 1:100 (mol/mol) mixture of a thiolated probe and an oligoethyleneglycol-terminated bipodal thiol. Detection of synthetic and PCR products was carried out in a sandwich type format, with the target hybridized between a surface immobilized probe and a horseradish peroxidase-labelled secondary reporter probe. The detection limits obtained in the detection of each individual target were in the pM range, allowing the application of this sensor...

Four-Year Follow-up of the Immunogenicity and Safety of the HPV-16/18 AS04-Adjuvanted Vaccine When Administered to Adolescent Girls Aged 10–14 Years

Journal of Adolescent Health — Sun, 22 Jan 2012 06:55:03 +0100

Conclusions: In adolescent girls, the HPV-16/18 AS04-adjuvanted vaccine produces anti-HPV-16 and anti-HPV-18 antibody titers that are maintained for up to 4 years at higher levels than those in young women in whom vaccine efficacy against cervical lesions was demonstrated. (Source: Journal of Adolescent Health)

Age-Specific Human Papillomavirus Antibody and Deoxyribonucleic Acid Prevalence: A Global Review

Journal of Adolescent Health — Sun, 22 Jan 2012 06:51:27 +0100

Conclusions: Females within the HPV vaccine-eligible age-group (9–26 years) had a range of dual HPV-16 DNA and serology negativity from 81%–87%, whereas 90%–98% were HPV-16 DNA negative. Serology and DNA data are lacking worldwide for females younger than age 15 years, the prime target group for vaccination. (Source: Journal of Adolescent Health)

Results in a New Study Published in the Annals of Medicine Show...

PRWeb: Medical Pharmaceuticals — Sat, 21 Jan 2012 05:56:11 +0100

The publication of the startling results of a Canadian study involving the effectiveness of the Human Papillomavirus (HPV) vaccine against cervical cancer demonstrate that vaccine policy and...(PRWeb January 18, 2012)Read the full story at http://www.prweb.com/releases/2012/1/prweb9112116.htm (Source: PRWeb: Medical Pharmaceuticals)

Association of HIV viral load and CD4 cell count with human papillomavirus detection and clearance in HIV‐infected women initiating highly active antiretroviral therapy

HIV Medicine — Fri, 20 Jan 2012 22:35:55 +0100

ConclusionsHigh‐risk HPV types vary among studies and can affect the results of analyses. Use of HAART to improve CD4 cell count may have an impact on the control of HPV infection. The decrease in VL may also have an effect, although to a lesser degree. (Source: HIV Medicine)

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Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review

BMC Cancer — Fri, 20 Jan 2012 05:00:00 +0100

Conclusions: The overall estimated epidemiological burden of HPV-related cancers and non-malignant diseases is high in men in Europe. Approximately 30% of all new cancer cases attributable to HPV16/18 that occur yearly in Europe were estimated to occur in men. As in women, the vast majority of HPV-positive cancer in men is related to HPV16/18, while almost all HPV-related non-malignant diseases are due to HPV6/11. A substantial number of these malignant and non-malignant diseases may potentially be prevented by quadrivalent HPV vaccination. (Source: BMC Cancer)

A comprehensive review on host genetic susceptibility to human papillomavirus infection and progression to cervical cancer

Indian Journal of Human Genetics — Fri, 20 Jan 2012 05:00:00 +0100

Koushik ChattopadhyayIndian Journal of Human Genetics 2011 17(3):132-144Cervical cancer is the second most common cancer in women worldwide. This is caused by oncogenic types of human papillomavirus (HPV) infection. Although large numbers of young sexually active women get HPV-infected, only a small fraction develop cervical cancer. This points to different co-factors for regression of HPV infection or progression to cervical cancer. Host genetic factors play an important role in the outcome of such complex or multifactor diseases such as cervical cancer and are also known to regulate the rate of disease progression. The aim of this review is to compile the advances in the field of host genetics of cervical cancer. MEDLINE database was searched using the terms, 'HPV', '...

Volumetric change of human papillomavirus–related neck lymph nodes before, during, and shortly after intensity‐modulated radiation therapy

Head and Neck — Fri, 20 Jan 2012 05:00:00 +0100

ConclusionHPV‐related LN behavior during IMRT is extremely variable but somewhat predictable on the basis of nodal density at planning. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)

Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer—systematic review and meta‐analysis of trends by time and region

Head and Neck — Fri, 20 Jan 2012 05:00:00 +0100

ConclusionsThe sharp increase in the proportion of HPV‐positive OPC over the last decade has occurred at a faster rate in Europe compared with that in North America. In contrast, the relatively low prevalence of HPV in non‐OPC remains unchanged. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)

Prevalence and Concordance of HPV, HIV, and HSV-2 in Heterosexual Couples in Kigali, Rwanda.

Herpes — Fri, 20 Jan 2012 03:31:34 +0100

CONCLUSION: : More than half of the couples were discordant for HIV, HPV, and/or HSV-2, indicating that prevention strategies directed to infected cases are important to protect their uninfected sexual partners. PMID: 22249302 [PubMed - in process] (Source: Herpes)

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Loss of gene function as a consequence of human papillomavirus DNA integration

International Journal of Cancer — Thu, 19 Jan 2012 05:00:00 +0100

AbstractIntegration of the HPV (human papillomavirus) genome into the host chromatin is a characteristic step in cervical carcinogenesis. Integration ensures constitutive expression of the viral oncogenes E6 and E7 which drive carcinogenesis. However, integration also has an impact on host DNA. There is increasing evidence that integration not only occurs in fragile sites and translocation breakpoints but also in transcriptionally active regions. Indeed, a substantial number of integration sites actually disrupt host genes and may thereby affect gene expression. No doubt, even subtle changes in gene expression may influence the cell phenotype but small fold changes are difficult to quantify reliably in biopsy material. We have therefore addressed the question whether a complete loss of gen...

EGFR gene copy number increase in vulvar carcinomas is linked with poor clinical outcome

Journal of Clinical Pathology — Thu, 19 Jan 2012 05:00:00 +0100

In conclusion, EGFR copy number increases are detectable in a substantial proportion of vulvar carcinomas with relationships to advanced tumour stages and the development of lymph node metastases. EGFR copy number aberrations are connected to other gene amplifications and probably define an human papillomaviruses-independent pathway in the development of vulvar carcinomas. These data support the potential utility of EGFR inhibitors as a therapeutic alternative in a subset of vulvar carcinomas. (Source: Journal of Clinical Pathology)

Transcriptional analysis of human papillomavirus type 16 in histological sections of cervical dysplasia by in situ hybridisation

Journal of Clinical Pathology — Thu, 19 Jan 2012 05:00:00 +0100

Conclusions This data represents new information on HPV-16 viral transcription events that bring into question some of the current beliefs on the mechanism of HPV-16 infection in the progression to cervical cancer. Results support high expression of the E5 and E7 oncogenes in cervical dysplasias infected by HPV-16 in contrast to the low levels identified for the E6 oncogene and a possible alternative transcript for the E2 gene. The diagnostic utility of the detection of HPV-16 RNA transcripts is becoming more apparent and a renewed look at their in situ localisation in cervical biopsies could be beneficial. (Source: Journal of Clinical Pathology)

Acceptability and uptake of HPV vaccine in Argentina before its inclusion in the immunization program: A population-based survey.

Vaccine — Thu, 19 Jan 2012 05:00:00 +0100

The objective was twofold: first to analyze socio-demographic determinants of women's knowledge on HPV vaccine and secondly, determinants of actual HPV vaccine uptake and acceptability in Argentina after the above-mentioned vaccine advertising shown in mass media in the year 2008. We analyzed vaccine uptake/acceptability separately for women and for their daughters aged 9-15, and willingness to vaccinate one's daughter younger than 9 to receive future HPV vaccination. Results of the 1200 women interviewed, 438 women (36.5%) knew the HPV vaccine and 303 (25%) remembered the mass media advertisement about HPV vaccination. When asked whether she would get vaccinated after having seen/heard the advertisement, around 75% (n=226) of women answered surely/probably yes. No significant differences ...

Reported Adverse Events in Young Women Following Quadrivalent Human Papillomavirus Vaccination

Journal of Women — Thu, 19 Jan 2012 04:10:01 +0100

Journal of Women's Health , Vol. 0, No. 0. (Source: Journal of Women)

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HPV infection has ‘distinct’ etiologic role in oral cancer

MedWire News - Oncology — Thu, 19 Jan 2012 00:00:00 +0100

Infection with human papillomavirus has a unique etiologic role in the development of oral squamous cell carcinoma, study findings suggest. (Source: MedWire News - Oncology)

Current Treatment Options for Metastatic Head and Neck Cancer

Current Treatment Options in Oncology — Wed, 18 Jan 2012 06:59:01 +0100

Opinion statement Head and neck squamous cell carcinoma is now the 8th most common cancer affecting men in the United States largely due to a rising epidemic of oropharynx cancer (tonsil and tongue base) associated with the human papillomavirus (HPV). The median overall survival for recurrent or metastatic head and neck cancer (R/M HNSCC) remains less than 1 year despite modern chemotherapy and targeted agents. Palliative chemotherapy and the epidermal growth factor receptor inhibitor, cetuximab, constitute the backbone of treatment for patients with R/M HNSCC. Platinum doublets studied in phase III trials include cisplatin/5-FU, cisplatin/paclitaxel, and cisplatin/pemetrexed. Platinum chemotherapy in combination with 5-fluorouracil and cetuximab has resulted in the longest...

Girls see need for safe sex even after HPV vaccination

Modern Medicine Contemporary Pediatrics — Wed, 18 Jan 2012 06:37:38 +0100

Adolescent girls believe that they are at less risk for human papillomavirus (HPV) infection after receiving their first HPV vaccination but also overwhelmingly believe in the need for continued safe sex behavior. One-fourth, however, perceive themselves to be at a lower risk for other sexually transmitted infections (STIs) after their first HPV vaccination. Find out why health care providers must talk to girls and their mothers about the limitations of HPV vaccine efficacy and the lack of protection from other STIs. (Source: Modern Medicine Contemporary Pediatrics)

Cost-effectiveness of cervical cancer screening: cytology versus human papillomavirus DNA testing.

BJOG : An International Journal of Obstetrics and Gynaecology — Wed, 18 Jan 2012 05:00:00 +0100

Conclusions Increasing the interval between screening rounds and changing the primary test from cytology to HPV testing can improve the effectiveness and decrease the costs of cervical cancer screening in the Netherlands. PMID: 22251259 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

Cost‐effectiveness of cervical cancer screening: cytology versus human papillomavirus DNA testing

BJOG: An International Journal of Obstetrics and Gynaecology — Wed, 18 Jan 2012 05:00:00 +0100

Conclusions Increasing the interval between screening rounds and changing the primary test from cytology to HPV testing can improve the effectiveness and decrease the costs of cervical cancer screening in the Netherlands. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)

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Girls see need for safe sex even after HPV vaccination

Modern Medicine — Wed, 18 Jan 2012 00:35:50 +0100

Gynecologic Cancer

Hematology/Oncology Clinics of North America — Tue, 17 Jan 2012 12:47:50 +0100

Like many areas in oncology, gynecologic oncology has made several important recent advances in both the prevention and the treatment of reproductive malignancies. New knowledge related to risk factors for endometrial and ovarian cancer has led to novel strategies to reduce risks through diet, contraception choices, and other factors. Important advances have also occurred in the understanding of genetic risks for gynecologic cancers and genetic testing can now identify individuals at substantial risk. Patients at genetic risk can reduce their risk through the use of oral contraception and other choices if they have not completed their families or undergo definitive prophylactic surgery when they no longer desire future pregnancies. Cervical cancer is an area of particular advancement in pr...

Help prevent cervical cancer with HPV vaccine

Baylor College of Medicine News — Tue, 17 Jan 2012 05:00:00 +0100

Getting the human papillomavirus, or HPV, vaccine provides an important preventative benefit against cervical cancer, said a gynecologic oncologist from Baylor College of Medicine . "Disease prevention and early detection are key in the battle against cancer," said Dr. Celestine Tung, an assistant professor in the department of obstetrics and gynecology in the division of gynecologic oncology at BCM. "With cervical cancer, now we have a way to prevent it with the HPV vaccine." HPV and cervical cancer Approximately 95 percent of cervical cancers are associated with HPV infections, and between 70 to 80 percent of cervical cancers are related to HPV 16 and HPV 18 viral subtypes or strains, Tung said. HPV is the most common sexually transmitted infection affecting between 3...

Topical vitamin A treatment of recalcitrant common warts

Virology Journal — Tue, 17 Jan 2012 05:00:00 +0100

Conclusion: Retinoids should be further investigated in controlled studies to determine their effectiveness in treating common warts and the broad range of other benign and cancerous lesions induced by HPVs. (Source: Virology Journal)

InterSCOPE Study: Associations Between Esophageal Squamous Cell Carcinoma and Human Papillomavirus Serological Markers

JNCI — Tue, 17 Jan 2012 05:00:00 +0100

Conclusions We found limited serological evidence of an association between esophageal squamous cell carcinoma and HPV in the populations studied. Although HPV does not appear to be an important risk factor for esophageal squamous cell carcinoma, we cannot exclude the possibility that certain HPV types may be involved in a small subset of cancers. (Source: JNCI)

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Squamous cell carcinoma metastatic to neck from an unknown primary: The potential impact of modern pathologic evaluation on perceived incidence of human papillomavirus–positive oropharyngeal carcinoma prior to 1970

The Laryngoscope — Tue, 17 Jan 2012 05:00:00 +0100

Conclusions:These two cases can be added to the other 15 cases of HPV‐positive primary oropharyngeal SCC identified in our department from 1956 to 1969. When determining the incidence of HPV‐positive oropharyngeal SCC before the 1970s, a correction factor of about +13% (2/15) accounting for modern pathologic workup of SCCUP during the last couple of decades may be appropriate. (Source: The Laryngoscope)

Monitoring HPV type-specific prevalence over time through clinic-based surveillance: A perspective on vaccine effectiveness.

Vaccine — Tue, 17 Jan 2012 05:00:00 +0100

Authors: Gaffga NH, Flagg EW, Weinstock HS, Shlay JC, Ghanem KG, Koutsky LA, Kerndt PR, Hsu KK, Unger ER, Datta SD Abstract We investigated the feasibility of monitoring trends in prevalence of vaccine-preventable human papillomavirus (HPV) types in different clinic populations. We collected cervical specimens from women presenting to family planning, primary care, and sexually transmitted disease (STD) clinics for routine pap smears in five US cities during 2003-2005. We performed HPV genotyping and calculated annual type-specific prevalences; pre-vaccine era prevalence was highest for HPV 16 (6.0; 95% confidence interval [CI] 5.5-6.6%) and annual prevalences for vaccine-preventable types were stable, with few exceptions, after controlling for clinic type, age group, and city. Wit...

High-risk human papillomavirus testing versus cytology in predicting post-treatment disease in women treated for high-grade cervical disease: A systematic review and meta-analysis.

Gynecologic Oncology — Tue, 17 Jan 2012 05:00:00 +0100

CONCLUSIONS: This review indicates that the hrHPV test should be included in post-treatment testing 6 months after treatment, because hrHPV testing has a higher sensitivity than cytology in detecting high-grade post-treatment disease and has a similar specificity. PMID: 22266548 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Penile Squamous Cell Carcinoma.

Actas Dermo-Sifiliograficas — Tue, 17 Jan 2012 05:00:00 +0100

Authors: Ferrándiz-Pulido C, de Torres I, García-Patos V Abstract Penile squamous cell carcinoma (SCC) is uncommon in Europe, where it accounts for approximately 0.7% of all malignant tumors in men. The main risk factors are poor hygiene, lack of circumcision, human papillomavirus (HPV) infection, and certain chronic inflammatory skin diseases. HPV infection is detected in 70% to 100% of all penile in situ SCCs and in 30% to 50% of invasive forms of the disease, mainly basaloid and warty SCCs. In situ tumors can be treated conservatively, but close monitoring is essential as they become invasive in between 1% and 30% of cases. The treatment of choice for penile SCC is surgery. Inguinal lymph node irradiation is no longer recommended as a prophylactic measure, and it appears that ...

High-Risk Cutaneous Squamous Cell Carcinoma.

Actas Dermo-Sifiliograficas — Tue, 17 Jan 2012 05:00:00 +0100

Authors: Nuño-González A, Vicente-Martín FJ, Pinedo-Moraleda F, López-Estebaranz JL Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and its incidence has increased in recent decades. Most cSCCs are successfully treated by surgery, but local and distant metastases develop in approximately 5% of cases; this proportion is higher in certain forms of cSCC with high-risk factors, namely: tumor size >2cm, depth >2mm, Clark level ≥IV, perineural invasion, lymphovascular invasion, poor differentiation, certain histologic subtypes (desmoplastic or adenosquamous carcinoma, invasive Bowen disease, or a cSCC arising in areas of chronic inflammation), immunosuppression, human papillomavirus infection, high-risk anatomic location (pinna ...

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Acquired Epidermodysplasia Verruciformis Syndrome in HIV-Infected Pediatric Patients: Prospective Treatment Trial With Topical Glycolic Acid and Human Papillomavirus Genotype Characterization [Research Letters]

Archives of Dermatology — Mon, 16 Jan 2012 05:00:00 +0100

(Source: Archives of Dermatology)

Confusion regarding cervical cancer screening and chlamydia screening among sexually active young women

Sexually Transmitted Infections — Sun, 15 Jan 2012 05:00:00 +0100

Conclusion Many younger women in an urban community health centre believed that cervical cancer screening also screens for chlamydia and were confused about chlamydia screening schedules. As there is limited knowledge of the revised ACOG cervical cancer screening guidelines, there is a risk that currently low chlamydia screening rates may decrease further after these new guidelines are better known. Obstetrician gynaecologists and primary care providers should educate younger women about the differences between chlamydia and cervical cancer screening and encourage sexually active younger women to have annual chlamydia screening. (Source: Sexually Transmitted Infections)

Assessment of Chlamydia trachomatis infection among Eastern European and West African women immigrants in South Italy

Sexually Transmitted Infections — Sun, 15 Jan 2012 05:00:00 +0100

Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection with an estimated incidence of 50 million cases in the world.1 The infection may remain asymptomatic or, if not treated, can lead to severe clinical manifestations including acute urethral syndrome, urethritis, bartholinitis, cervicitis, upper genital tract infections and perihepatitis.2 Despite the recognised need for early diagnosis and treatment of C trachomatis and other curable sexually transmitted infections, the strategies for detection of these infections are currently limited, particularly in low-resource countries.3 Migration and population mixing have been shown to increase the risk of sexually transmitted diseases;4 however, the prevalence and determinants of C trachomatis infection, and...

Matted nodes: Poor prognostic marker in oropharyngeal squamous cell carcinoma independent of HPV and EGFR status

Head and Neck — Sat, 14 Jan 2012 01:02:17 +0100

ConclusionMatted nodes are a novel marker of poor prognosis in oropharyngeal SCC independent of established prognostic factors. Matted nodes may identify patients at risk for the development of distant metastasis who could benefit from systemic therapy, whereas patients without matted nodes may be candidates for de‐escalation of therapy. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)

Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.

Clinical Cancer Research — Fri, 13 Jan 2012 05:00:00 +0100

CONCLUSIONS: Levels of SMG-1 expression negatively correlated with HPV status in cancer cell lines and tumors. Diminished SMG-1 expression may contribute to the enhanced response to therapy exhibited by HPV- positive HNSCCs. PMID: 22247495 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

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Reported Adverse Events in Young Women Following Quadrivalent Human Papillomavirus Vaccination

Journal of Women — Fri, 13 Jan 2012 04:13:28 +0100

Journal of Women's Health , Vol. 0, No. 0. (Source: Journal of Women)

Awareness and acceptability of human papillomavirus vaccine: An application of the instrumental variables bivariate probit model

BMC Public Health - Latest articles — Fri, 13 Jan 2012 03:50:22 +0100

Conclusions: Among populations who are not currently aware of the HPV vaccine, the potential impact of raising awareness on acceptability of HPV vaccination is substantial. This finding provides additional support to strengthening public health programs that increase awareness and policy efforts that address barriers to HPV vaccination. (Source: BMC Public Health - Latest articles)

Genital Seborrheic Keratoses are Human Papillomavirus‐Related Lesions. A Linear Array Genotyping Test Study

APMIS — Thu, 12 Jan 2012 05:00:00 +0100

Tardío JC, Bancalari E, Moreno A, Martín‐Fragueiro LM. Genital Seborrheic Keratoses are Human Papillomavirus‐Related Lesions. A Linear Array Genotyping test study. APMIS 2012.Controversy exists about the meaning of human papillomavirus (HPV) detection in seborrheic keratosis (SK). To clarify the pathogenic contributing role of HPV in the development of genital SK, we have studied 40 genital SKs, 20 extragenital SKs, and 20 non‐SK genital lesions by polymerase chain reaction for HPV, using a Linear Array Genotyping test that detects 37 genital HPV types. Twenty‐eight of the 40 genital SK specimens (70%) were positive for HPV. Twenty‐seven of the 28 positive cases (96%) contained HPV6, one of them associated to HPV18 and HPV35 (4%), and the remaining lesion (4%) harbored HPV55. H...

Race and sexual behavior predict uptake of the human papillomavirus vaccine.

Health Psychology — Mon, 09 Jan 2012 05:00:00 +0100

Conclusion: Racial disparities in use of preventive interventions such as the HPV vaccine exist. Lack of information about public financing of the vaccine, timing of vaccination relative to sexual activity, and perceptions of preventive value may limit uptake among those at highest risk for infection and negative sequelae from infection. Further research to probe knowledge and attitudes toward HPV vaccination and the impact of the media on vaccine initiation and uptake may reveal specific targets of intervention. (PsycINFO Database Record (c) 2012 APA, all rights reserved) (Source: Health Psychology)

Risk assessment and clinical impact of liquid-based cytology, oncogenic human papillomavirus (HPV) DNA and mRNA testing in primary cervical cancer screening (The FASE Study).

Gynecologic Oncology — Mon, 09 Jan 2012 05:00:00 +0100

CONCLUSIONS: These data corroborate the suitability of AHPV for the primary cervical cancer screening. PMID: 22233689 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Cancer-related deaths continue to decline in US

Guardian Unlimited Science — Thu, 05 Jan 2012 20:13:24 +0100

American Cancer Society's annual report cites advances in cancer screening and treatment for falling numbersCancer death rates are continuing to fall, dropping by 1.8% per year in men and 1.6% per year in women between 2004 and 2008, according to the American Cancer Society's annual report on cancer statistics released on Wednesday.Advances in cancer screening and treatment have prevented more than a million total deaths from cancer since the early 1990s, according to the report.But the influential cancer group said new cases of seven less-common cancers rose in the past decade, suggesting more could be done in America's 40-year war on cancer.This year, the cancer group projects 1,638,910 people will be newly diagnosed with cancer and 577,190 people will die from it."The big news this year...

Giant Condyloma of Buschke-Lowenstein: An Atypical CaseGiant Condyloma of Buschke-Lowenstein: An Atypical Case

Medscape Today Headlines — Thu, 05 Jan 2012 18:50:52 +0100

An uncommonly aggressive case of giant condyloma of Buschke-Lowenstein is found in an atypical patient. Medscape Gastroenterology (Source: Medscape Today Headlines)

Reducing HPV Infection - Single-Sex Vaccination Has Best Effect

Health News from Medical News Today — Thu, 05 Jan 2012 16:00:00 +0100

According to a study in PLoS Medicine, the most effective strategy to protect against human papillomavirus (HPV) is single-sex vaccination. They also found that it was preferable to vaccinate females instead of men, given that females are the sex with the highest prevaccine prevalence of HPV infection. Johannes Bogaards, of the VU University in the Netherlands and his team decided to assess whether vaccinating either just females or males, or both sexes would be the best approach to achieve the most effective reduction of sexually transmitted infections amongst the general population... (Source: Health News from Medical News Today)

Prevalence of infection by different genotypes of human papillomavirus in women with cervical pathology.

Gynecologic Oncology — Thu, 05 Jan 2012 05:00:00 +0100

CONCLUSIONS: In the population we studied, the proportion of women with infection by different genotypes of HPV 16 and HPV 18 was high. This finding confirms the need for further studies to compare the efficacy and protection of current vaccines against intraepithelial lesions and cervical cancer. PMID: 22226808 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Successful Treatment of Refractory Wart with a Topical Activated Vitamin D in a Renal Transplant Recipient

Clinical and Developmental Immunology — Wed, 04 Jan 2012 14:29:49 +0100

Warts are benign proliferations of the skin and mucosa caused by infection with human papillomavirus. They are commonly treated with destructive modalities such as cryotherapy with liquid nitrogen, local injection of bleomycin, electrocoagulation, topical application of glutaraldehyde, and local and systemic interferon-β therapy. These treatment modalities often cause pain and sometimes scarring or pigmentation after treatment. We herein report a case with a right index finger wart, which was successfully treated with a topical activated vitamin D. (Source: Clinical and Developmental Immunology)

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Girls Who Get HPV Vaccine Still Value Safe Sex (CME/CE)

MedPage Today Infectious Disease — Wed, 04 Jan 2012 13:00:00 +0100

(MedPage Today) -- Most girls who receive the human papillomavirus (HPV) vaccine don't take it as a license for riskier sexual behavior, researchers reported. (Source: MedPage Today Infectious Disease)

Human papillomavirus-16 (HPV-16) infection association with CIAP-2 expression in head and neck cancer

Medical Oncology — Wed, 04 Jan 2012 07:00:21 +0100

In this study, we aimed to search for the amplification of the locus bearing CIAP-2 and its relation to HPV-16 in head and neck cancer that may have prognostic and therapeutic impacts on these patients. Total 30 patients diagnosed as head and neck cancer (2 tissue samples were taken from each patient: from the tumor and from the safety margin). All samples were subjected to qualitative polymerase chain reaction analysis for HPV-16 and qualitative and semiquantitative reverse transcription polymerase chain reaction of CIAP-2. There was a significant association between HPV-16 and CIAP2 positivity and head and neck tumors (P = 0.01). CIAP-2 expression in malignant tissues was highly associated with HPV-16 infection with 73.9% sensitivity and absolute specificity. Content...

Automated Detection of Dual p16/Ki67 Nuclear Immunoreactivity in Liquid-Based Pap Tests for Improved Cervical Cancer Risk Stratification.

Annals of Biomedical Engineering — Wed, 04 Jan 2012 05:00:00 +0100

In this study, an automated technique for the evaluation of dual p16/Ki67 immunoreactivity in cervical cell nuclei is introduced. Smears stained with p16 and Ki67 antibodies were digitized, and analyzed by algorithms we developed. Gradient-based radial symmetry operator and adaptive processing of symmetry image were employed to obtain the nuclear mask. This step was followed by the extraction of features including pixel data and immunoreactivity signature from each nucleus. The features were analyzed by two support vector machine classifiers to assign a nucleus into one of four types of immunoreactivity: p16 positive (p16(+)/Ki67(-)), Ki67 positive (p16(-)/Ki67(+)), dual p16/Ki67 positive (p16(+)/Ki67(+)) and negative (p16(-)/Ki67(-)), respectively. Results obtained by our method correlate...

Medicaid reimbursement and the uptake of adolescent vaccines.

Vaccine — Wed, 04 Jan 2012 05:00:00 +0100

CONCLUSIONS: Our results suggest that, contrary to what has been shown for childhood vaccines, raising Medicaid reimbursement rates may not improve adolescent vaccine utilization. Instead, other policy changes may be more effective, such as expansion of VFC programs into universal purchase programs, further implementation of school-based vaccine mandates and efforts to raise preventive care visits among adolescents. PMID: 22226859 [PubMed - as supplied by publisher] (Source: Vaccine)

Human Papillomavirus as a Favorable Prognostic Biomarker in Squamous Cell Carcinomas of the Vagina.

Gynecologic Oncology — Wed, 04 Jan 2012 05:00:00 +0100

CONCLUSIONS: HPV-positive early stage (FIGO I and II) VaSCC have a better prognosis than early HPV-negative tumors. HPV detection and/or p16(INK4a) immunostaining can be easily implemented in routine pathology and should be considered as valuable prognostic biomarkers in the study of patients with VaSCC. PMID: 22226684 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

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Cancers with increasing incidence trends in the United States: 1999 through 2008

CA: A Cancer Journal for Clinicians — Wed, 04 Jan 2012 05:00:00 +0100

AbstractDespite declines in incidence rates for the most common cancers, the incidence of several cancers has increased in the past decade, including cancers of the pancreas, liver, thyroid, and kidney and melanoma of the skin, as well as esophageal adenocarcinoma and certain subsites of oropharyngeal cancer associated with human papillomavirus (HPV) infection. Population‐based incidence data compiled by the North American Association of Central Cancer Registries were used to examine trends in incidence rates from 1999 through 2008 for the 7 cancers listed by sex, age group, race/ethnicity, and stage at diagnosis. Joinpoint regression was used to calculate average annual percent changes in incidence rates (1999‐2008). Rates for HPV‐related oropharyngeal cancer, esophageal adenocarcin...

Adolescent Perceptions of Risk and Need for Safer Sexual Behaviors After First Human Papillomavirus Vaccination [Article]

Archives of Pediatrics — Mon, 02 Jan 2012 05:00:00 +0100

Conclusions Few adolescents perceived less need for safer sexual behaviors after the first HPV vaccination. Education about HPV vaccines and encouraging communication between girls and their mothers may prevent misperceptions among these adolescents. (Source: Archives of Pediatrics)

Increasing mammography and cervical cancer knowledge and screening behaviors with an educational program.

Oncology Nursing Forum — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions: Educational interventions based on self-efficacy increased knowledge of breast and cervical health and helped increase the rate of mammography and Pap tests.Implications for Nursing: Preparing women with strategies to complete a mammogram and Pap test is an important approach to enhancing self-efficacy and increasing screening behaviors. PMID: 22201656 [PubMed - in process] (Source: Oncology Nursing Forum)

[Comment] Success of HPV vaccination is now a matter of coverage

The Lancet Oncology — Sun, 01 Jan 2012 05:00:00 +0100

In a pair of articles in The Lancet Oncology, Lehtinen and colleagues and Wheeler and colleagues present 4-year end-of-study data from a trial of a prophylactic human papillomavirus (HPV)-16/-18 vaccine (Cervarix, GlaxoSmithKline) in young women aged 15–25 years. From a public-health perspective, these studies have several important contributions. (Source: The Lancet Oncology)

[Articles] Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial

The Lancet Oncology — Sun, 01 Jan 2012 05:00:00 +0100

SummaryBackgroundHuman papillomavirus (HPV) testing is more sensitive for the detection of high-grade cervical lesions than is cytology, but detection of HPV by DNA screening in two screening rounds 5 years apart has not been assessed. The aim of this study was to assess whether HPV DNA testing in the first screen decreases detection of cervical intraepithelial neoplasia (CIN) grade 3 or worse, CIN grade 2 or worse, and cervical cancer in the second screening.MethodsIn this randomised trial, women aged 29–56 years participating in the cervical screening programme in the Netherlands were randomly assigned to receive HPV DNA (GP5+/6+-PCR method) and cytology co-testing or cytology testing alone, from January, 1999, to September, 2002. (Source: The Lancet Oncology)

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[Articles] Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial

The Lancet Oncology — Sun, 01 Jan 2012 05:00:00 +0100

We report vaccine efficacy against CIN3+ and adenocarcinoma in situ (AIS) in the end-of-study analysis of PATRICIA (PApilloma TRIal against Cancer In young Adults). (Source: The Lancet Oncology)

[Articles] Cross-protective efficacy of HPV-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by non-vaccine oncogenic HPV types: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial

The Lancet Oncology — Sun, 01 Jan 2012 05:00:00 +0100

SummaryBackgroundWe evaluated the efficacy of the human papillomavirus HPV-16/18 AS04-adjuvanted vaccine against non-vaccine oncogenic HPV types in the end-of-study analysis after 4 years of follow-up in PATRICIA (PApilloma TRIal against Cancer In young Adults).MethodsHealthy women aged 15–25 years with no more than six lifetime sexual partners were included in PATRICIA irrespective of their baseline HPV DNA status, HPV-16 or HPV-18 serostatus, or cytology. Women were randomly assigned (1:1) to HPV-16/18 vaccine or a control hepatitis A vaccine, via an internet-based central randomisation system using a minimisation algorithm to account for age ranges and study sites. (Source: The Lancet Oncology)

Female Long-Term Survivors After Allogeneic Hematopoietic Stem Cell Transplantation: Evaluation and Management

Seminars in Hematology — Sun, 01 Jan 2012 05:00:00 +0100

Female long-term survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) incur a significant burden of late effects. Genital graft-versus-host disease (GVHD), human papillomavirus (HPV) reactivation, ovarian failure and infertility, sexual dysfunction, and osteoporosis are concerns that can significantly impact quality of life. This review examines the risk, pathogenesis, clinical presentation, and implications of these common complications. Recommendations are provided for evaluation and management of these late effects and other obstetric and gynecologic issues that may arise in this patient population. (Source: Seminars in Hematology)

Impact of HPV Vaccine Availability on Uptake

The Journal for Nurse Practitioners — Sun, 01 Jan 2012 05:00:00 +0100

Abstract: Purpose: To evaluate the impact of human papillomavirus (HPV) vaccine availability on uptake among 19- to 26-year-old female patients of Planned Parenthood of Mid and South Michigan before and after the vaccine became available at the health centers. Results: Availability of the HPV vaccine increased vaccine uptake from 11% before clinic availability to 16% after availability. Accessibility, including cost and provider recommendation, may have influenced uptake. Implications: Improving availability of the HPV vaccine, while helpful, is not sufficient for a substantial increase in uptake. Issues of accessibility, including cost and provider recommendation, must also be addressed. (Source: The Journal for Nurse Practitioners)

The Food and Drug Administration's Post‐Licensure Rapid Immunization Safety Monitoring program: strengthening the federal vaccine safety enterprise

Pharmacoepidemiology and Drug Safety — Sun, 01 Jan 2012 05:00:00 +0100

ABSTRACTIn 2009, the Department of Health and Human Services created the new Post‐Licensure Rapid Immunization Safety Monitoring (PRISM) program, which used data from national health insurance plans and immunization registries to monitor the safety of the H1N1 influenza vaccine. PRISM has now been integrated into the FDA's Mini‐Sentinel pilot program. It strengthens the federal vaccine safety enterprise in two important ways. First, PRISM monitors the largest US general population cohort designated for active surveillance of vaccine safety. Second, PRISM links data from health plans with data from state and city immunization registries, which were a crucial source of exposure data in the H1N1 vaccine evaluation. The Mini‐Sentinel data that support PRISM are updated quarterly, and PRI...

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Epidemiology of Sexually Transmitted Infections, HIV, and Related High-Risk Behaviors among Female Sex Workers in Guangxi Autonomous Region, China.

Japanese Journal of Infectious Diseases — Sun, 01 Jan 2012 05:00:00 +0100

This study assessed the epidemiology of sexually transmitted infections (STIs), HIV, and associated risk factors among female sex workers (FSWs) in Guangxi autonomous region, China. A cross-sectional study of 488 FSWs was conducted using a structured questionnaire to collect sociodemographic and behavioral information. Biological specimens from subjects were sampled to detect various STIs and HIV infection. Among FSWs, the prevalence rates of syphilis, Neisseria gonorrhoeae, Chlamydia trachomatis, genital herpes, condyloma acuminate, and HIV were 7.2%, 1.8%, 18.2%, 0.4%, 2.3%, and 0.8%, respectively. The prevalence rates of single, double, and triple infections were 22.3%, 3.9%, and 0.20%, respectively. Multivariate analysis indicated that STIs and HIV infection was independently related t...

Review of Screening Guidelines for Non-AIDS-Defining Malignancies: Evolving Issues in the Era of Highly Active Antiretroviral Therapy.

AIDS Reviews — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Tyerman Z, Aboulafia DM Abstract HIV-associated morbidity and mortality have declined dramatically in the era of HAART. Through direct and indirect benefits of HAART, people with HIV/AIDS are living longer, developing less AIDS-defining cancers and more cancers commonly seen in the seronegative population. Herein, we review cancer screening strategies for people living with HIV and compare and contrast them with those of the general population. The most noticeable differences occur in anal and cervical cancer screening. Although anal cancer is uncommon in the general population, it is more prevalent in men who have sex with men and people at high risk for human papillomavirus infection, especially those infected with HIV. To address this, we recommend that a digital rectal...

Follow-up and Treatment of Renal Transplantation with Nephropathic Cystinosis in Central Taiwan

Transplantation Proceedings — Sun, 01 Jan 2012 05:00:00 +0100

Conclusions: The extrarenal complications with nephropathic cystinosis are high. These 2 siblings had only have ocular involvement without further cysteamine therapy. However, long-term follow-up is required to monitor development of complications and determine their prognoses. (Source: Transplantation Proceedings)

Low risk of type‐specific carcinogenic HPV re‐appearance with subsequent cervical intraepithelial neoplasia grade 2/3

International Journal of Cancer — Sat, 31 Dec 2011 05:00:00 +0100

AbstractCarcinogenic human papillomavirus (HPV) infections are very common after sexual debut and nearly all become undetectable (“clear”) within a few years. Following clearance, the long‐term risks of type‐specific HPV re‐appearance and subsequent risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) are not well defined.In the 7‐year, population‐based cohort study in Guanacaste, Costa Rica, we studied how often type‐specific carcinogenic HPV infections re‐appeared after clearance, and how often re‐appearance led to CIN2+. We considered 1740 carcinogenic HPV infections detected by MY09/11 PCR among 2805 women (18‐91 years old, median 34) who were actively followed at 6‐ or 12‐ month intervals. We identified women with 1 or more type‐specific HPV ...

Human papillomavirus 8 E6 disrupts terminal skin differentiation and prevents pro-Caspase-14 cleavage.

Virus Research — Sat, 31 Dec 2011 05:00:00 +0100

In conclusion, in the raft system, HPV8 E6 prevented late-terminal keratinocyte differentiation resulting in an accumulation of Filaggrin and pro-Caspase-14-positive cells in the absence of stratification. This differentiation arrest was accompanied by the failure to express Caspase-14 subunits, suggesting absence of Caspase-14 activation and probable abrogation of Filaggrin maturation in HPV8 E6-expressing keratinocytes. PMID: 22230316 [PubMed - as supplied by publisher] (Source: Virus Research)

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Scientists buzz Simon Cowell for promoting pseudoscience

Guardian Unlimited Science — Wed, 28 Dec 2011 07:30:00 +0100

Sense About Science publishes its annual review of celebrities' misleading claims, including Cowell's intravenous vitaminsWhere there's a celebrity, there's often a fad diet, miracle crystal bracelet or misunderstanding about science. In 2011, Simon Cowell thought it was best to get his vitamins delivered intravenously, American TV host Bill O'Reilly reckoned the Earth's tides were a mystery, and Gwyneth Paltrow championed expensive detox treatments.These celebrity missteps, and many others, are highlighted in the sixth annual review published by the charity Sense About Science (SAS). "We're seeing changes – people are contacting us, medical charities are briefing their celebrities more and working with us to follow up dangerous advice, and we now have over 5,000 scientists and hundreds ...

Human papillomavirus in upper digestive tract tumors from three countries.

World Journal of Gastroenterology : WJG — Wed, 28 Dec 2011 05:00:00 +0100

CONCLUSION: Based on our results, we cannot deny the possibility of HPV16 involvement in the carcinogenesis of the esophagus. PMID: 22219599 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Small Biopsy Specimens Reliably Indicate p16 Expression Status of Oropharyngeal Squamous Cell Carcinoma

Head and Neck Pathology — Tue, 27 Dec 2011 16:49:47 +0100

Abstract Human papillomavirus (HPV)—related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable patient survival. Tumor HPV status at primary diagnosis is critical for proper management, and p16 immunohistochemistry (IHC) has emerged as a reliable, single, surrogate marker. It is not known, however, if small biopsy specimens are completely adequate for p16 evaluation. From a database of oropharyngeal SCC for which p16 IHC and histologic typing were already performed, all patients (32) who had available in-house primary tumor biopsy specimens and also subsequent surgical resections were analyzed. p16 IHC was performed along with histologic typing into: Type 1 keratinizing SCC, Type 2 nonkeratinizing SCC with maturation, and Type 3 nonkeratinizing SCC....

Vital Signs: No Link Is Seen Between HPV Vaccine and Girls’ Sexual Risks

NYT Health — Mon, 26 Dec 2011 18:30:37 +0100

A survey has found that girls ages 15 to 19 who are vaccinated against human papillomavirus, or HPV, are no more likely to be sexually active. (Source: NYT Health)

Recognition of nonkeratinizing morphology in oropharyngeal squamous cell carcinoma – a prospective cohort and interobserver variability study*

Histopathology — Sun, 25 Dec 2011 17:26:12 +0100

Conclusions: Pathologists can recognize NK SCC with good agreement, and when a pathologist classifies a tumour as NK SCC, this reliably predicts p16 positivity. (Source: Histopathology)

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Acceptability of self-collected human papillomavirus specimens as a primary screen for cervical cancer.

Pain Physician — Sat, 24 Dec 2011 11:06:14 +0100

Authors: Quincy BL, Turbow DJ, Dabinett LN Abstract The aim of this study was to compare the acceptability of self-collected vs clinician-collected human papillomavirus (HPV) tests. Utilising a cross-sectional approach, 250 non-pregnant, 25-60-year-old women from Leon, Nicaragua self-collected vaginal swabs and brushes for HPV and received a pelvic examination for liquid-based cytology and reflex HPV. Subjects underwent colposcopy, with biopsy if indicated, and completed questionnaires comparing their perceptions of HPV testing methods. Acceptability indices were significantly higher for self-collected brushes (M = 18.40, SD = 2.73) and swabs (M = 18.48, SD = 2.41) than clinician-collection (M = 17.56, SD = 2.92), p < 0.001. Multiple regression analyses revealed that age, educat...

HPV Vaccine Does Not Alter Sexual Behavior

Health News from Medical News Today — Sat, 24 Dec 2011 08:00:00 +0100

According to a national study by The Centers for Disease Control & Prevention published in the American Journal of Preventive Medicine, contrary to some people's belief, young women receiving recommended vaccinations for the prevention of human papillomavirus (HPV) infection and related cancers do not engage in more sexually risky behavior. Nicole C. Liddon, Ph.D... (Source: Health News from Medical News Today)

Recommendations on the Use of Quadrivalent Human Papillomavirus Vaccine in Males — Advisory Committee on Immunization Practices (ACIP), 2011

CDC Morbidity and Mortality Weekly Report — Sat, 24 Dec 2011 04:35:49 +0100

(Source: CDC Morbidity and Mortality Weekly Report)

Recommendations on the Use of Quadrivalent Human Papillomavirus Vaccine in Males - Advisory Committee on Immunization Practices (ACIP), 2011.

MMWR Morb Mortal Wkl... — Fri, 23 Dec 2011 05:00:00 +0100

Authors: Abstract On October 25, 2011, the Advisory Committee on Immunization Practices (ACIP) recommended routine use of quadrivalent human papillomavirus (HPV) vaccine (HPV4; Gardasil, Merck & Co. Inc.) in males aged 11 or 12 years. ACIP also recommended vaccination with HPV4 for males aged 13 through 21 years who have not been vaccinated previously or who have not completed the 3-dose series; males aged 22 through 26 years may be vaccinated. These recommendations replace the October 2009 ACIP guidance that HPV4 may be given to males aged 9 through 26 years. For these recommendations, ACIP considered information on vaccine efficacy (including data available since October 2009, on prevention of grade 2 or 3 anal intraepithelial neoplasia [AIN2/3], a precursor of anal cancer)...

Gardasil recommended for all U.S. boys

Health News - UPI.com — Fri, 23 Dec 2011 03:54:11 +0100

ATLANTA, Dec. 22 (UPI) -- Centers for Disease Control and Prevention officials recommend vaccinating all U.S. boys ages 11 or 12 with the quadrivalent human papillomavirus vaccine. (Source: Health News - UPI.com)

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Female-Only HPV Vaccination Most Effective (CME/CE)

MedPage Today Pediatrics — Thu, 22 Dec 2011 17:43:11 +0100

(MedPage Today) -- Increasing vaccination for the human papillomavirus (HPV) among pre-adolescent girls is more effective than extending existing programs to include boys, according to a range of transmission models. (Source: MedPage Today Pediatrics)

Safety and Immunogenicity Profile of Human Papillomavirus-16/18 AS04 Adjuvant Cervical Cancer Vaccine: A Randomized Controlled Trial in Healthy Adolescent Girls of Bangladesh

Japanese Journal of Clinical Oncology — Thu, 22 Dec 2011 05:00:00 +0100

Conclusions The human papillomavirus-16/18 AS04-adjuvanted vaccine was generally well tolerated and highly immunogenic when administered to young adolescent females and could be a promising tool for the prevention and control of cervical cancer in Bangladesh. (Source: Japanese Journal of Clinical Oncology)

Adding phase to HPV vaccine policy could save lives, money

CTV Health — Thu, 22 Dec 2011 00:17:00 +0100

A new study says protecting women aged 17 to 26 against the human papillomavirus or HPV in a catch-up vaccination round would save lives -- and save millions of dollars in the process. (Source: CTV Health)