MedWorm: Helicobacter Pylori

MISHIMA - a new method for high speed multiple alignment of nucleotide sequences of bacterial genome scale data

BMC Bioinformatics - Latest articles — Thu, 18 Mar 2010 00:00:00 +0100

Conclusions: MISHIMA provides improved performance compared to the commonly used multiple alignment methods. As an example, six complete genome sequences of bacteria species Helicobacter pylori (about 1.7Mb each) were successfully aligned in about 6 hours using a single PC. (Source: BMC Bioinformatics - Latest articles)

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Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?

NeLM - Disease Focused Reviews — Wed, 17 Mar 2010 00:00:00 +0100

Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: This generally well-conducted review concluded that Helicobacter pylori eradication treatment appeared to reduce gastric cancer risk, but the generalisability of the findings may be limited. Also, they are based on evidence of variable reliability. These conclusions are an accurate reflection the results of the review and appear to be reliable. [Eradication treatment regimes included differing combinations and doses of the following agents: amoxicillin, metronidazole, bismuth subsalicylate, omeprazole, lansoprazole, clarithromycin. ] CRD Commentary: The review question was clear and was supported by specific inclusion criteria. The search included a number of relevant databases and other sources. This, along with the l...

The chemical-in-plug bacterial chemotaxis assay is prone to false positive responses

BMC Research Notes — Tue, 16 Mar 2010 00:00:00 +0100

Conclusions: Our results suggest that the chemical-in-plug assay should be used with caution, that non-motile or non-chemotactic mutants should be employed as controls, and that results should be confirmed with other types of assays. (Source: BMC Research Notes)

Treponema pallidum immunostain distinguishing syphilitic gastritis from Helicobacter pylori-associated gastritis

Human Pathology — Mon, 15 Mar 2010 15:18:14 +0100

We read with interest the article by Martin-Ezquerra et al describing the distribution of treponemal organisms in primary and secondary syphilis. Unsurprisingly, a Treponema pallidum immunostain was more sensitive than the Warthin-Starry (WS) stain in detecting the organisms. Although not discussed in their article, one would expect it to be also more specific. This became evident in a case of secondary syphilis we recently encountered where, despite the detection of microorganisms by a WS stain, was originally misdiagnosed partly because syphilis was not clinically suspected at the outset. (Source: Human Pathology)

Using Antibiotics To Prevent Gastric Cancer

Health News from Medical News Today — Mon, 15 Mar 2010 07:00:00 +0100

Helicobacter pylori, a bacterium found in about 50% of humans worldwide, can cause stomach ulcers and, in extreme cases, gastric cancer. In an article for F1000 Medicine Reports, Seiji Shiota and Yoshio Yamaoka discuss the possible eradication of H. pylori infections Infection by the H. pylori bacterium can approach 100% in developing countries. Most infected people do not have symptoms, but many develop problems including stomach ulcers. H... (Source: Health News from Medical News Today)

Using Antibiotics To Prevent Gastric Cancer

Cancer / Oncology News From Medical News Today — Mon, 15 Mar 2010 07:00:00 +0100

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Does Cholesterol Really Matter?

NaturalNews.com — Mon, 15 Mar 2010 07:00:00 +0100

(NaturalNews) I'd like to shine the spotlight on one of medicine's sacred cows- the belief that lowering cholesterol with drugs protects against heart attacks and premature death. Our obsession with cholesterol began in the 1950s when studies linked high consumption of animal fat with high rates of heart disease. This opened the door for clinical trials that laid the foundation of a new paradigm: the cholesterol theory of cardiovascular disease.This theory has had profound ramifications. It changed the way we eat (fats bad, carbohydrates good) and contributed to our problems with obesity and diabetes. It wormed its way into "clinical practice guidelines"- cholesterol management has become a "standard of care" that doctors are expected to follow. It spawned the invasive heart surgery indust...

Genetic polymorphisms in DNA repair genes XPC, XPD, and XRCC4, and susceptibility to Helicobacter pylori infection-related gastric antrum adenocarcinoma in Guangxi population, China

Molecular Carcinogenesis — Mon, 15 Mar 2010 00:00:00 +0100

This study, including 361 GAAs and 616 controls without any evidence of tumors, was designed to evaluate the association between the polymorphisms of DNA repair genes XPC Ala499Val (RS#2228000) and Lys939Gln (RS#2228001), XPD Lys751Gln (RS#13181), and XRCC4 Ala247Ser (RS#3734091) and Ser298Asn (RS#1805377), and GAA risk for Guangxi population by means of TaqMan-PCR analysis. Increased risks of GAA were found for individuals with H. pylori positive [odds ratio (OR), 2.48; 95% confidence interval (CI), 1.84-3.33] or cagA positive (OR, 7.34; 95% CI, 5.46-9.87). No differences were observed among the studied groups with regard to the genotype distribution of XPC codons 499 and 939 and of XRCC4 codon 247; but XPD codon 751 genotypes with Gln [ORs (95% CI) were 2.67 (1.98-3.58) and 3.97 (2.64-5....

Association between Helicobacter pylori infection and gastroduodenal lesions in patients with chronic liver disease

Arquivos de Gastroenterologia — Sat, 13 Mar 2010 14:23:58 +0100

CONCLUSION: Patients with chronic liver disease showed higher risk of developing gastroduodenal lesions regardless of the presence of the H. pylori infection. (Source: Arquivos de Gastroenterologia)

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System

Arquivos de Gastroenterologia — Sat, 13 Mar 2010 14:23:58 +0100

CONCLUSIONS: Chronic active gastritis was observed in all patients with H. pylori infection. However, antral or corporeal predominance was not observed in most patients. (Source: Arquivos de Gastroenterologia)

Adverse effects of proton pump inhibitors

Best Practice & Research. Clinical Gastroenterology — Sat, 13 Mar 2010 14:21:59 +0100

Proton pump inhibitors (PPI) are very effective drugs used largely in acid related disorders. During the last years concern have been raised regarding their overutilisation in benign condition, such as gastroesophageal reflux disease. The debate focussed also on the risk of adverse events related to long term use of PPI. Apart of the case of Helicobacter Pylori (H. Pylori) positive patients, in whose long term acid suppression lead to the development of corpus predominant atrophic gastritis, precursor of cancer; the other assumed adverse events, have never been demonstrated in prospective studies. The attention should move towards the appropriate prescription of PPI, rather than the fear adverse effects of PPI. In fact, in clinical practise, PPI are often prescribed in patients without a s...

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Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer.

World Journal of Gastroenterology : WJG — Fri, 12 Mar 2010 17:05:20 +0100

Authors: Sugimoto M, Yamaoka Y, Furuta T Pro-inflammatory cytokines are produced in the gastric mucosa by inflammatory cells activated by chronic Helicobacter pylori (H. pylori) infection. Polymorphisms of these cytokine genes are associated with individual differences in gastric mucosal cytokine mRNA level, which result in differences in gastric mucosal inflammation, acid inhibition and gastroduodenal disease risk in response to H. pylori infection. Although polymorphisms of interleukin (IL)-1B, IL-1RN and TNF-A have been reported to relate well with gastric cancer and peptic ulcer risk, those of IL-2, IL-4, IL-6 and IL-8 genes are unclear. In combined analyses using data from previous studies, we found that the risk of gastric non-cardia cancer development was significantly associate...

Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas.

World Journal of Gastroenterology : WJG — Fri, 12 Mar 2010 17:05:17 +0100

CONCLUSION: Epigenetic inactivation of GATA-4 (and GATA-5) by methylation of CpG islands is an early frequent event during gastric carcinogenesis and is significantly correlated with H. pylori infection. PMID: 20222162 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Influence of efflux pump inhibitors on the multidrug resistance of Helicobacter pylori.

World Journal of Gastroenterology : WJG — Fri, 12 Mar 2010 17:04:17 +0100

CONCLUSION: In vitro, some EPIs can strengthen the activities of different antibiotics which are the putative substrates of the efflux pump system in H. pylori. PMID: 20222174 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Preventing gastric cancer with antibiotics

Medicineworld.org: New Article Alert — Fri, 12 Mar 2010 13:04:27 +0100

Helicobacter pylori, a bacterium found in about 50% of humans worldwide, can cause stomach ulcers and, in extreme cases, gastric cancer. In an article for F1000 Medicine Reports, Seiji Shiota and Yoshio Yamaoka discuss the possible eradication of H. pylori infections. Infection by the H. pylori bacterium can approach 100% in developing countries. Most infected people do not have symptoms, but a number of develop problems including stomach ulcers. H. pylori causes more than 90% of all duodenal ulcers and can also contribute to the development of gastric cancer, which is one of the world's biggest medical problems........ (Source: Medicineworld.org: New Article Alert)

Preventing gastric cancer with antibiotics

EurekAlert! - Social and Behavioral Science — Fri, 12 Mar 2010 05:00:00 +0100

(Faculty of 1000: Biology and Medicine) Helicobacter pylori, a bacterium found in about 50 percent of humans worldwide, can cause stomach ulcers and, in extreme cases, gastric cancer. In an article for F1000 Medicine Reports, Seiji Shiota and Yoshio Yamaoka discuss the possible eradication of H. pylori infections (Source: EurekAlert! - Social and Behavioral Science)

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Association of c.802C>T polymorphism of NOD2/CARD15 gene with the chronic gastritis and predisposition to cancer in H. pylori infected patients.

Experimental and Molecular Pathology — Fri, 12 Mar 2010 00:00:00 +0100

Association of c.802C>T polymorphism of NOD2/CARD15 gene with the chronic gastritis and predisposition to cancer in H. pylori infected patients. Exp Mol Pathol. 2010 Mar 12; Authors: Hnatyszyn A, Slomski R, Szalata M, Stanczyk J, Cichy W This paper shows analysis of the association of the 802C>T polymorphism of the NOD2/CARD15 gene with the occurrence of the chronic inflammation of the gastric mucosa associated with the Helicobacter pylori infections, development of intestinal metaplasia and dysplasia and, in the result of this, gastric cancer. Genomic DNA samples were extracted from paraffin blocks of gastric mucosal biopsies and from peripheral blood. H. pylori infection was confirmed by histological analysis and urease test. Pyrosequencing of 802C>T polymorphism of ...

In vitro susceptibility to antimicrobial agents and ultrastructural characteristics related to swimming motility and drug action in Campylobacterjejuni and C. coli

Journal of Infection and Chemotherapy — Thu, 11 Mar 2010 18:14:36 +0100

In this study, we examined in vitro susceptibility to 36 antimicrobial agents of 109 strains of C. jejuni and C. coli isolated from chickens and patients with enteritis or Guillain–Barré syndrome from 1996 to 2009. Among these agents, carbapenems (imipenem, meropenem, panipenem, and biapenem) showed the greatest activity [minimal inhibitory concentration (MIC)90, 0.03–0.125 μg/ml]. This was followed by sitafloxacin (MIC90, 0.25 μg/ml), furazolidone and azithromycin (MIC90, 0.5 μg/ml), gentamicin and clindamycin (MIC90, 1 μg/ml), and clavulanic acid (β-lactamase inhibitor; MIC90, 2 μg/ml). All or most strains were resistant to aztreonam, sulfamethoxazole, and trimethoprim. Marked resistance was also observed for levofloxacin and tetracyclines. Resistan...

Prescreening of a High-Risk Group for Gastric Cancer by Serologically Determined Helicobacter pylori Infection and Atrophic Gastritis

Digestive Diseases and Sciences — Wed, 10 Mar 2010 18:48:04 +0100

Conclusions A high-risk group for gastric cancer can be selected by serological prescreening. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1154-0Authors Shigeto Mizuno, Kobe Pharmaceutical University Department of Medical Pharmaceutics 4-19-1 Motoyama-kita, Higashinada-ku Kobe 658-8558 JapanIkuya Miki, Kobe Pharmaceutical University Department of Medical Pharmaceutics 4-19-1 Motoyama-kita, Higashinada-ku Kobe 658-8558 JapanTsukasa Ishida, Kobe Pharmaceutical University Department of Medical Pharmaceutics 4-19-1 Motoyama-kita, Higashinada-ku Kobe 658-8558 JapanMasaru Yoshida, Kobe University Division of Gastroenterology, Graduate School of Medicine 7-5-2 Kusunoki-cho, Chuo-ku Kobe 650-0017 JapanMitsuko Onoyama, Kobe University Division of G...

Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen

BMC Genomics - Latest articles — Wed, 10 Mar 2010 00:00:00 +0100

Conclusions: The determination of the genome sequence and expressed proteome of the ulcerogenic species H mustelae provides a comparative model for H. pylori to investigate bacterial gastric carcinogenesis in mammals, and to suggest ways whereby cag minus H. pylori strains might cause ulceration and cancer.The genome sequence was deposited in EMBL/GenBank/DDBJ under accession number FN555004. (Source: BMC Genomics - Latest articles)

Molecular detection of host cytokine expression in

Indian Journal of Medical Microbiology — Tue, 09 Mar 2010 17:15:51 +0100

Hosseini M Eshagh, Oghalaie A, Habibi G, Nahvijoo A, Hosseini Z M, Tashakoripoor M, Mohammadi MIndian Journal of Medical Microbiology 2010 28(1):40-44Background: Helicobacter pylori (Hp) is a bacterium recognised as a main causative agent for the development of chronic active gastritis, peptic ulcer disease, gastric adenocarcinoma and primary gastric lymphoma. Objective: Determination of the levels of IFN-&#947; (pro-inflammatory) and IL-4 (anti inflammatory) cytokine expression as indicators of Th1 and Th2 immune responses in gastric cancer (GC) and non gastric cancer (Non GC) dyspeptic patients by gene specific RT-PCR. Materials and Methods: Biopsy specimens were collected from three groups of gastric cancer (GC=18), non ulcer dyspepsia (NUD = 38) and peptic ulcer patients (PU...

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Short-duration furazolidone therapy in combination with amoxicillin, bismuth subcitrate, and omeprazole for eradication of

The Saudi Journal of Gastroenterology — Tue, 09 Mar 2010 14:34:37 +0100

Conclusion: One week of furazolidone in combination with 2 weeks of amoxicillin, omeprazole, and bismuth subcitrate is a safe and cost-effective regimen for the eradication of H pylori. Adding metronidazole to the above regimen does not increase the eradication rate. (Source: The Saudi Journal of Gastroenterology)

Type 2 diabetes mellitus: A risk factor for

International Journal of Diabetes in Developing Countries — Tue, 09 Mar 2010 14:27:06 +0100

Conclusion: Diabetic patients are more prone and at risk to acquire H. Pylori infection. Therefore proper monitoring of blood glucose level and screening for H. pylori infection are effective preventive measures for this life threatening infection. (Source: International Journal of Diabetes in Developing Countries)

Breastfeeding protects children against peptic ulcer bacterium

EurekAlert! - Medicine and Health — Sun, 07 Mar 2010 05:00:00 +0100

(University of Gothenburg) Young children in developing countries are infected at an early age with the bacterium Helicobacter pylori, which can cause peptic ulcers and stomach cancer. New findings show that childrens´ immune responses help in fighting the bacteria. In addition, breastfeeding and better hygiene appear to protect against infection. The results provide hope for a vaccine, according to research from the Sahlgrenska Academy at the University of Gothenburg, Sweden. (Source: EurekAlert! - Medicine and Health)

Calbiotech Inc - H. Pylori IgM ELISA 96 Well Kit - Class 2 Recall

Medical Device Recalls since July 07, 2006 — Sat, 06 Mar 2010 02:00:02 +0100

H. Pylori IgM ELISA 96 Well Kit, Catalog Number: HP015M The products in question are all Enzyme Linked Immunosorbent Assay (ELISA) Test kits designed and marketed for Research Use Only. (Source: Medical Device Recalls since July 07, 2006)

Calbiotech Inc - H. Pylori IgA ELISA 96 Well Kit - Class 2 Recall

Medical Device Recalls since July 07, 2006 — Sat, 06 Mar 2010 02:00:02 +0100

H. Pylori IgA ELISA 96 Well Kit, Catalog Number: HP014A The products in question are all Enzyme Linked Immunosorbent Assay (ELISA) Test kits designed and marketed for Research Use Only. (Source: Medical Device Recalls since July 07, 2006)

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Etiological approach to chronic urticaria

Indian Journal of Dermatology — Fri, 05 Mar 2010 14:02:58 +0100

Conclusion: Nearly half of the patients had chronic autoimmune urticaria on the basis of ASST. A significant number of them had serological makers of autoimmune activity. ASST provides an easy, inexpensive investigation in CU and helps direct attention to underlying systemic auto immune diseases. The presence of these auto antibodies was significantly associated with more frequent and longer lasting urticarial attacks. Exhaustive work ups with extensive laboratory diagnostics, challenge tests, and prick testing should be reserved for individual cases following detailed history. (Source: Indian Journal of Dermatology)

Bismuth-Based First-Line Therapy for Helicobacter pylori Eradication in Type 2 Diabetes Mellitus Patients

Digestion — Thu, 04 Mar 2010 23:00:00 +0100

Digestion 2010;82:4753 (DOI:10.1159/000236024) (Source: Digestion)

Helicobacter pylori with or without its neutrophil-activating protein may be the common denominator associated with multiple sclerosis and neuromyelitis optica

Multiple Sclerosis — Thu, 04 Mar 2010 15:11:15 +0100

(Source: Multiple Sclerosis)

Authors' reply to 'Helicobacter pylori with or without its neutrophil-activating protein may be the common denominator associated with multiple sclerosis and neuromyelitis optica'

Multiple Sclerosis — Thu, 04 Mar 2010 15:11:15 +0100

(Source: Multiple Sclerosis)

Gene regulation: Can we stomach it? New technique fights against cause of peptic ulcer disease and gastric cancer

ScienceDaily Headlines — Thu, 04 Mar 2010 10:00:00 +0100

A breakthrough in decoding gene regulation of Helicobacter pylori has been made by an international research team. Using a newly developed sequencing technique, the researchers discovered 60 small ribonucleic acids -- tiny RNA-particles which can regulate genes -- in the genome of this human pathogen. These findings could facilitate the development of new therapeutic strategies against this widespread pathogen. (Source: ScienceDaily Headlines)

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Direct repression of sonic hedgehog expression in the stomach by Cdx2 leads to intestinal transformation

BJ Disease — Thu, 04 Mar 2010 00:00:00 +0100

In conclusion, Cdx2 reduced Shh expression by binding to the unmethylated Shh promoter in the intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach. (Source: BJ Disease)

Direct repression of sonic hedgehog expression in the stomach by Cdx2 leads to intestinal transformation.

The Biochemical Journal — Thu, 04 Mar 2010 00:00:00 +0100

In conclusion, Cdx2 reduced Shh expression by binding to the unmethylated Shh promoter in the intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach. PMID: 20199401 [PubMed - as supplied by publisher] (Source: The Biochemical Journal)

Role of Probiotics in Pediatric Patients with Helicobacter pylori Infection: A Comprehensive Review of the Literature

Helicobacter — Wed, 03 Mar 2010 14:26:27 +0100

Conclusion: Both in vitro and in vivo studies provide evidence that probiotics may represent a novel approach to the management of H. pylori infection. (Source: Helicobacter)

Associations Between Helicobacter pylori Infection, Co-Morbid Infections, Gastrointestinal Symptoms, and Circulating Cytokines in African Children

Helicobacter — Wed, 03 Mar 2010 00:00:00 +0100

Conclusions: There is a high prevalence of asymptomatic H. pylori infection in recently resettled African refugee children. Gastrointestinal symptoms were not predictive of H. pylori nor of helminth infections. Serum cytokines, particularly IL-5, IL-10, and TNF[alpha], were significantly elevated in children with malaria and helminth infections but not in those with H. pylori infection. (Source: Helicobacter)

Presence of Helicobacter pylori in a Sibling is Associated with a Long-Term Increased Risk of H. pylori Infection in Israeli Arab Children

Helicobacter — Wed, 03 Mar 2010 00:00:00 +0100

Conclusions: Most H. pylori infections are acquired at preschool age and transient infection beyond this age is uncommon in this population. Helicobacter pylori-infected siblings are the major reservoir of H. pylori in early and late childhood demonstrating sustained intra-familial transmission of H. pylori. (Source: Helicobacter)

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Type I Restriction–Modification Loci Reveal High Allelic Diversity in Clinical Helicobacter pylori Isolates

Helicobacter — Wed, 03 Mar 2010 00:00:00 +0100

Discussion: We propose that the genetic variability of hsdS genes in a bacterial population will give rise to new specificities of these enzymes, which might lead to adaptation to an ever-changing gastric environment. (Source: Helicobacter)

Comparison of the Efficacy of the Two Tetracycline-Containing Sequential Therapy Regimens for the Eradication of Helicobacter Pylori: 5 days Versus 14 days Amoxicillin

Helicobacter — Wed, 03 Mar 2010 00:00:00 +0100

Conclusion: Extended duration of amoxicillin treatment during the entire tetracycline containing sequential therapy period did not improve the H. pylori eradication rate. As a consequence, sequential therapy using 5-day amoxicillin is an acceptable first-line therapy option for the eradication of H. pylori in Turkey. (Source: Helicobacter)

Ten-Day Sequential Therapy as First-line Treatment for Helicobacter pylori Infection in Korea: A Retrospective Study

Helicobacter — Wed, 03 Mar 2010 00:00:00 +0100

Conclusions: Ten-day sequential therapy is found to effectively eradicate H. pylori infection as first-line treatment in Korea. (Source: Helicobacter)

A Randomized Controlled Trial: Efficacy and Safety of Azithromycin, Ofloxacin, Bismuth, and Omeprazole Compared With Amoxicillin, Clarithromycin, Bismuth, and Omeprazole as Second-Line Therapy in Patients With Helicobacter pylori Infection

Helicobacter — Wed, 03 Mar 2010 00:00:00 +0100

Conclusion: Two weeks of treatment with ofloxacin, azithromycin, omeprazole, and bismuth is an effective and safe regimen for H. pylori eradication as second-line therapy. (Source: Helicobacter)

The Continuous Story of Helicobacter pylori Infection and Insulin Resistance: This Time in Japan

Helicobacter — Wed, 03 Mar 2010 00:00:00 +0100

(Source: Helicobacter)

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Major Health Risks in Aging Persons With Intellectual Disabilities: An Overview of Recent Studies

Journal of Policy and Practice in Intellectual Disabilities — Wed, 03 Mar 2010 00:00:00 +0100

The authors examined the health-related literature on aging and intellectual disabilities (ID) published since 1999, with specific focus on examining findings on age-associated health risk factors, such as cardiovascular, gastrointestinal, and musculoskeletal system health issues, and age-related oral health. They also examined studies of lifestyle health risks, primarily the contributions to overweight or obesity. Although the review revealed varying differences in the prevalence of health risk factors, significant evidence is emerging that cardiovascular disease is as prevalent among people with ID and is as common a cause of death as in the general population. However, the review showed that the variations in prevalence were culturally dependent. Digestive system problems were evident w...

Helicobacter pylori acidic stress response factor HP1286 is a YceI homolog with new binding specificity

FEBS Journal — Wed, 03 Mar 2010 00:00:00 +0100

HP1286 from Helicobacter pylori is among the proteins that play a relevant role in bacterial colonization and persistence in the stomach. Indeed, it was demonstrated to be overexpressed under acidic stress conditions, together with other essential virulence factors. Here we describe its crystal structure, determined at 2.1 Å resolution. The molecular model, a dimer characterized by two-fold symmetry, shows that HP1286 structurally belongs to the YceI-like protein family, which in turn is characterized by the lipocalin fold. The latter characterizes proteins possessing an internal cavity with the function of binding and/or transport of amphiphilic molecules. Surprisingly, a molecule of erucamide was found bound in the internal cavity of each monomer of recombinant HP1286, cloned and expres...

Could Helicobacter pylori play an important role in axonal type of Guillain-Barré Syndrome pathogenesis?

Clinical Neurology and Neurosurgery — Tue, 02 Mar 2010 17:56:24 +0100

Abstract: In this case-control study, ELISA and Western blot with whole bacterial protein lysate were performed on serum and cerebrospinal fluid (CSF) of 15 controls and 15 patients. According to Griffin subtypes, 10 of our patients were in acute inflammatory demyelinating polyradiculoneuropathy (AIDP) group, 3 in acute motor axonal neuropathy (AMAN) group, and 2 in acute motor sensory axonal neuropathy (AMSAN) subtype. 86.6% of patients were positive for Helicobacter pylori (H. pylori) IgG. Serum anti-H. pylori IgG of patients and controls were significantly different. CSF anti-H. pylori IgG was significantly higher in patients than controls. In patients, the titer of anti-H. pylori IgG in serum was significantly higher than CSF, which may indicate extra-neural antibody synthesis. CSF IgG...

Dual proton pump inhibitor plus amoxicillin as an empiric anti-H. pylori therapy: studies from the United States

Journal of Gastroenterology — Tue, 02 Mar 2010 10:01:51 +0100

Conclusions If the hypothesis that consistently high intragastric pH is required to reliably achieve more than 90% H. pylori eradication, our regimen was not sufficient. Success may require more than every 8 h dosing, the concomitant administration of sodium bicarbonate, or the use of a long-acting PPI. However, the result was positive in that dual therapy with the doses tested here was at least as successful as empiric triple therapy. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-010-0220-xAuthors David Y. Graham, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine Department of Medicine RM 3A-320 (111D), 2002 Holcombe Boulevard Houston TX 77030 USASyed Ussama Javed, Michael E. DeBakey ...

Breastfeeding Protects Children Against Peptic Ulcer Bacterium

Health News from Medical News Today — Tue, 02 Mar 2010 08:00:00 +0100

Young children in developing countries are infected at an early age with the bacterium Helicobacter pylori, which can cause peptic ulcers and stomach cancer. New findings show that childrensÂ´ immune responses help in fighting the bacteria. In addition, breastfeeding and better hygiene appear to protect against infection. The results provide hope for a vaccine, according to research from the Sahlgrenska Academy at the University of Gothenburg, Sweden... (Source: Health News from Medical News Today)

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Breastfeeding Protects Children Against Peptic Ulcer Bacterium

Immune System / Vaccines News From Medical News Today — Tue, 02 Mar 2010 08:00:00 +0100

Young children in developing countries are infected at an early age with the bacterium Helicobacter pylori, which can cause peptic ulcers and stomach cancer. New findings show that childrensÂ´ immune responses help in fighting the bacteria. In addition, breastfeeding and better hygiene appear to protect against infection... (Source: Immune System / Vaccines News From Medical News Today)

Helicobacter pylori and its role in vocal folds' minimal lesions

The Clinical Respiratory Journal — Tue, 02 Mar 2010 00:00:00 +0100

Conclusion: HP is a common finding in cases of VFML; its eradication should be considered when dealing with a patient with VFML. Please cite this paper as: Tiba M, Fawaz S and Osman H. Helicobacter pylori and its role in vocal folds' minimal lesions. Clin Respir J 2010; DOI:10.1111/j.1752-699X.2009.00182.x. (Source: The Clinical Respiratory Journal)

A preliminary approach to creating an overview of lactoferrin multi-functionality utilizing a text mining method.

Biometals — Tue, 02 Mar 2010 00:00:00 +0100

Authors: Shimazaki KI, Kushida T Lactoferrin is a multi-functional metal-binding glycoprotein that exhibits many biological functions of interest to many researchers from the fields of clinical medicine, dentistry, pharmacology, veterinary medicine, nutrition and milk science. To date, a number of academic reports concerning the biological activities of lactoferrin have been published and are easily accessible through public data repositories. However, as the literature is expanding daily, this presents challenges in understanding the larger picture of lactoferrin function and mechanisms. In order to overcome the "analysis paralysis" associated with lactoferrin information, we attempted to apply a text mining method to the accumulated lactoferrin literature. To this end, we used the in...

Association Between Helicobacter pylori and Gastrointestinal Symptoms in Children

PEDIATRICS — Mon, 01 Mar 2010 16:02:29 +0100

CONCLUSIONS: We found no association between RAP and H pylori infection in children and conflicting evidence for an association between epigastric pain and H pylori infection. We found evidence for an association between UAP but could not confirm this finding in children seen in primary care. (Source: PEDIATRICS)

Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology.

Cellular and Molecular Immunology — Mon, 01 Mar 2010 00:00:00 +0100

This article will review the recent novel findings on the interactions of H. pylori with diverse host epithelial signaling pathways and events involved in the initiation of gastric pathology, including gastric inflammation, mucosal damage and development of MALT lymphomas. PMID: 20190789 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Immunology)

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The study on the antibacterial activity of compounds from the isodon species.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Isobe T, Nagata K We investigated antibacterial activities of ten compounds from Isodon species against five strains of Escherichia coli, Staphylococcus epidermidis, Serratia marcescens, Streptococcus mutans, and Helicobacter pylori. The compounds with the MIC values of 25 mug/ml were isodocarpin against Sta. epidermidis, Str. mutans, and H. pylori, nodosin against Sta. epidermidis and Str. mutans, oridonin against Ser. marcescens, and pedalitin against H. pylori. PMID: 20190530 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)

In vitro Antibacterial and Morphological Effects of the Urushiol Component of the Sap of the Korean lacquer tree (Rhus vernicifera Stokes) on Helicobacter pylori.

J Korean Med Sci — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Suk KT, Kim HS, Kim MY, Kim JW, Uh Y, Jang IH, Kim SK, Choi EH, Kim MJ, Joo JS, Baik SK Eradication regimens for Helicobacter pylori infection have some side effects, compliance problems, relapses, and antibiotic resistance. Therefore, alternative anti-H. pylori or supportive antimicrobial agents with fewer disadvantages are necessary for the treatment of H. pylori. We investigated the pH-(5.0, 6.0, 7.0, 8.0, 9.0, and 10.0) and concentration (0.032, 0.064, 0.128, 0.256, 0.514, and 1.024 mg/mL)-dependent antibacterial activity of crude urushiol extract from the sap of the Korean lacquer tree (Rhus vernicifera Stokes) against 3 strains (NCTC11637, 69, and 219) of H. pylori by the agar dilution method. In addition, the serial (before incubation, 3, 6, and 10 min after incubation)...

Endoscopic-Bioptic Diagnostics, Surveillance of and Therapy for Gastrointestinal Diseases According to Guidelines.

Zeitschrift fur Gastroenterologie — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Warich-Eitel S, Fischbach W, Eck M The present review summarises the detailed recommendations for an optimal endoscopic-bioptic diagnostic procedure, endoscopic surveillance of and therapy for gastrointestinal diseases. The recommendations are mainly based on the S 3-guidelines and have been developed by histopathologists and gastroenterologists in interdisciplinary work. The material has been arranged according to topographic regions of the gastrointestinal tract and clinical problems. The focus is placed on diagnostic and surveillance of Barrett's oesophagus, therapy and postoperative treatment for early gastrointestinal carcinoma, management of colon polyps and endoscopic surveillance of inflammatory bowel disease. Treatment recommendations for both ulcerative colitis and C...

Med Sci Monit 2010; 16(3):CR144-148 "Recurrence of Helicobacter pylori infection 1 year after successful eradication: A prospective study in Northern Iran"

Medical Science Monitor — Fri, 26 Feb 2010 19:37:00 +0100

Conclusions: According to these data, the H. pylori recurrence rate in our region is 5% after successful eradication. (Source: Medical Science Monitor)

Book Review: Helicobacter pylori: Molecular Genetics and Cellular Biology

QRB Latest Issue — Thu, 25 Feb 2010 16:38:37 +0100

The Quarterly Review of Biology, Volume 85, Issue 1, Page 110, March 2010. (Source: QRB Latest Issue)

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Gene Regulation: Can We Stomach It?

Health News from Medical News Today — Thu, 25 Feb 2010 08:00:00 +0100

A breakthrough in decoding gene regulation of Helicobacter pylori has been made by an international research team led by Jorg Vogel of the Max Planck Institute for Infection Biology in Berlin. Using a newly developed sequencing technique, the re-searchers discovered 60 small ribonucleic acids (sRNAs) - tiny RNA-particles which can regulate genes - in the genome of this human pathogen. These findings could facilitate the development of new therapeutic strategies against this wide-spread pathogen. About 50 percent of the world's population carry Helicobacter pylori (H... (Source: Health News from Medical News Today)

Gene Regulation: Can We Stomach It?

GastroIntestinal News From Medical News Today — Thu, 25 Feb 2010 08:00:00 +0100

A breakthrough in decoding gene regulation of Helicobacter pylori has been made by an international research team led by Jorg Vogel of the Max Planck Institute for Infection Biology in Berlin. Using a newly developed sequencing technique, the re-searchers discovered 60 small ribonucleic acids (sRNAs) - tiny RNA-particles which can regulate genes - in the genome of this human pathogen... (Source: GastroIntestinal News From Medical News Today)

Treating H. Pylori Bacteria Effective for Gastric Lymphoma

Modern Medicine — Thu, 25 Feb 2010 00:00:00 +0100

Eradication of Helicobacter pylori in the stomachs of patients with early-stage gastric lymphoma results in the remission of approximately 75 percent of them, according to a meta-analysis reported in the February issue of Clinical Gastroenterology and Hepatology. (Source: Modern Medicine)

The Role of Infection in Carotid Plaque Pathogenesis and Stability: The Clinical Evidence.

Current Vascular Pharmacology — Thu, 25 Feb 2010 00:00:00 +0100

CONCLUSION: There is considerable evidence supporting the contribution of other commonly encountered pathogens in the pathogenesis and rupture of the carotid plaque. Research in this direction should not be abandoned and further studies are necessary to elucidate the exact role of common infections in the pathogenesis and development of CPD and how this can be translated into novel pharmacological approaches for prevention and treatment. PMID: 20180770 [PubMed - as supplied by publisher] (Source: Current Vascular Pharmacology)

Stomach-Specific Controlled Release Gellan Beads of Acid-Soluble Drug Prepared by Ionotropic Gelation Method.

AAPS PharmSciTech — Wed, 24 Feb 2010 00:00:00 +0100

Authors: Narkar M, Sher P, Pawar A The purpose of the present work was the development and evaluation of stomach-specific controlled release mucoadhesive drug delivery system prepared by ionotropic gelation of gellan beads, containing acid-soluble drug amoxicillin trihydrate, using 3(2) factorial design with concentration of gellan gum and quantity of drug as variables. The study showed that beads prepared in alkaline cross-linking medium have higher entrapment efficiency than the acidic cross-linking medium. The entrapment efficiency was in the range of 32% to 46% w/w in acidic medium, which increased up to 60% to 90% w/w in alkaline medium. Batches with lowest, medium, and highest drug entrapment were subjected to chitosan coating to form a polyelectrolyte complex film. As polymer co...

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Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan

Journal of Gastroenterology — Tue, 23 Feb 2010 07:55:59 +0100

Conclusion During long-term PPI therapy, FGP development was associated with absence of Hp infection. Meanwhile, Hp infection and high SGL may influence HPP development. Content Type Journal ArticleCategory Original Article—Alimentary TractDOI 10.1007/s00535-010-0207-7Authors Michio Hongo, Tohoku University Hospital Departments of Comprehensive Medicine and Psychosomatic Medicine 1-1 Seiryo-machi, Aoba Sendai Miyagi 980-8574 JapanKazuma Fujimoto, Saga Medical School Department of Internal Medicine Saga JapanGastric Polyps Study Group Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology)

Gene regulation: Can we stomach it?

EurekAlert! - Medicine and Health — Tue, 23 Feb 2010 05:00:00 +0100

(Max-Planck-Gesellschaft) A breakthrough in decoding gene regulation of Helicobacter pylori has been made by an international research team led by Jorg Vogel of the Max Planck Institute for Infection Biology in Berlin. Using a newly developed sequencing technique, the researchers discovered 60 small ribonucleic acids -- tiny RNA-particles which can regulate genes -- in the genome of this human pathogen. These findings could facilitate the development of new therapeutic strategies against this widespread pathogen. (Source: EurekAlert! - Medicine and Health)

Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin

BMC Microbiology - Latest articles — Tue, 23 Feb 2010 00:00:00 +0100

Conclusions: These results indicate that within the beta-helical segment of the VacA p55 domain, there are regions of plasticity that tolerate alterations without detrimental effects on protein secretion or activity, as well as a carboxy-terminal region in which similar alterations result in protein misfolding and impaired secretion. We propose that non-essential beta-helical coils and a carboxy-terminal beta-helical segment required for proper protein folding and secretion are features shared by numerous autotransporter passenger domains. (Source: BMC Microbiology - Latest articles)

H. pylori-induced promoter hypermethylation downregulates USF1 and USF2 transcription factor gene expression

Cellular Microbiology — Tue, 23 Feb 2010 00:00:00 +0100

Helicobacter pylori infection is associated with the development of gastric adenocarcinoma. Upstream stimulatory factors USF1 and USF2 regulate the transcription of genes related to immune response, cell cycle and cell proliferation. A decrease in their expression is observed in human gastric epithelial cells infected with H. pylori, associated to a lower binding to their DNA E-box recognition site as shown by electrophoretic mobility shift assay. DNA methylation leads to gene silencing. The treatment of cells with 5'-azacytidine, an inhibitor of DNA methylation, restored the USF1 and USF2 gene expression in the presence of infection. Using promoter PCR methylation assay, a DNA hypermethylation was shown in the promoter region of USF1 and USF2 genes, in infected cells. The inhibition of US...

Review Found No Link Between Pediatric Abdominal Pain and H pylori Infection

Medscape Today Headlines — Sat, 20 Feb 2010 01:07:13 +0100

A systematic review showed no link between recurrent abdominal pain and H pylori infection, and conflicting evidence for a link between epigastric pain and H pylori infection. Medscape Medical News (Source: Medscape Today Headlines)

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High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period

Neural Plasticity — Thu, 18 Feb 2010 16:46:53 +0100

This paper describes an individual who was diagnosed with obsessive-compulsive disorder (OCD) and body dysmorphic disorder (BDD) at age 17 when education was discontinued. By age 19, he was housebound without social contacts except for parents. Adequate trials of three selective serotonin reuptake inhibitors, two with atypical neuroleptics, were ineffective. Major exacerbations following ear infections involving Group A β-hemolytic streptococcus at ages 19 and 20 led to intravenous immune globulin therapy, which was also ineffective. At age 22, another severe exacerbation followed antibiotic treatment for H. pylori. This led to a hypothesis that postulates deficient signal transduction by the N-methyl-D-aspartate receptor (NMDAR). Treatment with glycine, an NMDAR coagonist, over 5 y...

Type 2 diabetes mellitus: A risk factor for Helicobacter pylori infection: A hospital based case-control study

International Journal of Diabetes in Developing Countries — Thu, 18 Feb 2010 14:13:23 +0100

Conclusion: Diabetic patients are more prone and at risk to acquire H. Pylori infection. Therefore proper monitoring of blood glucose level and screening for H. pylori infection are effective preventive measures for this life threatening infection. (Source: International Journal of Diabetes in Developing Countries)

Efficacy of Standard Triple Therapy in the Treatment of Helicobacter pylori Infection: Experience from Kuwait

Digestive Diseases and Sciences — Thu, 18 Feb 2010 06:51:43 +0100

Conclusion The efficacy of the current standard triple therapy for H. pylori eradication in our community is suboptimal. Confirmation for H. pylori eradication with noninvasive tests is recommended, especially in high-risk patients. New antimicrobial regimens for H. pylori eradication are considered necessary. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1139-zAuthors Waleed M. Alazmi, Amiri Hospital Thunayan Alghanim Center of Gastroenterology Kuwait City KuwaitWaleed Buhaimed, Amiri Hospital Thunayan Alghanim Center of Gastroenterology Kuwait City KuwaitKhalid Al-Mekhaizeem, Amiri Hospital Thunayan Alghanim Center of Gastroenterology Kuwait City KuwaitIqbal Siddique, Amiri Hospital Thunayan Alghanim Center of Gastroenterology Kuwait Ci...

Characterization of an N6 adenine methyltransferase from Helicobacter pylori strain 26695 which methylates adjacent adenines on the same strand

FEBS Journal — Thu, 18 Feb 2010 00:00:00 +0100

Genomic sequences of Helicobacter pylori strains 26695, J99, HPAGI and G27 have revealed an abundance of restriction and modification genes. hp0050, which encodes an N6 adenine DNA methyltransferase, was cloned, overexpressed and purified to near homogeneity. It recognizes the sequence 5'-GRRG-3' (where R is A or G) and, most intriguingly, methylates both adenines when R is A (5'-GAAG-3'). Kinetic analysis suggests a nonprocessive (repeated-hit) mechanism of methylation in which HP0050 methyltransferase methylates one adenine at a time in the sequence 5'-GAAG-3'. This is the first report of an N6 adenine DNA methyltransferase that methylates two adjacent residues on the same strand. Interestingly, HP0050 homologs from two clinical strains of H. pylori (PG227 and 128) methylate only 5'-GAGG...

Complexity of Gastric Acid Secretion Revealed by Targeted Gene Disruption in Mice.

Current Pharmaceutical Design — Thu, 18 Feb 2010 00:00:00 +0100

Authors: Chen D, Zhao CM Physiology of gastric acid secretion is one of the earliest subjects in medical research and education. Gastric acid secretion has been sometimes inadequately expressed as pH value rather than amount of gastric H+ secreted per unit time. Gastric acid secretion is regulated by endocrine, paracrine and neurocrine signals via at least three messenger pathways: gastrin-histamine, CCK-somatostatin, and neural network. These pathways have been largely validated and further characterized by phenotyping a series of knockout mouse models. The complexity of gastric acid secretion is illustrated by both expected and unexpected phenotypes of altered acid secretion. For examples, in comparison with wild-type mice, gastrin and CCK double knockout and SSTR2 knockout mice disp...

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The primary transcriptome of the major human pathogen Helicobacter pylori

Nature AOP — Wed, 17 Feb 2010 00:00:00 +0100

The primary transcriptome of the major human pathogen Helicobacter pylori

Nature — Wed, 17 Feb 2010 00:00:00 +0100

Authors: Cynthia M. Sharma, Steve Hoffmann, Fabien Darfeuille, Jérémy Reignier, Sven Findeiß, Alexandra Sittka, Sandrine Chabas, Kristin Reiche, Jörg Hackermüller, Richard Reinhardt, Peter F. Stadler & Jörg Vogel Genome sequencing of Helicobacter pylori has revealed the potential proteins and genetic diversity of this prevalent human pathogen, yet little is known about its transcriptional organization and noncoding RNA output. Massively parallel cDNA sequencing (RNA-seq) has been revolutionizing global transcriptomic analysis. Here, using a (Source: Nature)

Carotid Plaque Thickness Tied to Past Infections

Medscape Medical News Headlines — Tue, 16 Feb 2010 18:32:18 +0100

Past or chronic exposure to five common infections -- Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus and herpes simplex virus (HSV)-1 and HSV-2 - seems to be associated with atherosclerotic plaque buildup in the carotid arteries, which raises the risk of stroke, according to a report in the March issue of Stroke. Reuters Health Information (Source: Medscape Medical News Headlines)

CDKN2A promoter methylation is related to the tumor location and histological subtype and associated with Helicobacter pylori flaA(+) strains in gastric adenocarcinomas

APMIS — Tue, 16 Feb 2010 00:00:00 +0100

Alves MKS, Lima VP, Ferrasi AC, Rodrigues MA, de Moura Campos Pardini MI, Rabenhorst SHB. CDKN2A promoter methylation is related to the tumor location and histological subtype and associated with Helicobacter pylori flaA(+) strains in gastric adenocarcinomas. APMIS 2010. Promoter hypermethylation of CDKN2A (p16INK4A protein) is the main mechanism of gene inactivation. However, its association with Helicobacter pylori infection is a controversial issue. Therefore, we examined a series of gastric adenocarcinomas to assess the association between p16INK4A inactivation and H. pylori genotype (vacA, cagA, cagE, virB11 and flaA) according to the location and histological subtype of the tumors. p16INK4A expression and CDKN2A promoter methylation were found in 77 gastric adenocarcinoma samples by ...

Increased levels of serum IL-31 in chronic spontaneous urticaria*

Experimental Dermatology — Tue, 16 Feb 2010 00:00:00 +0100

Please cite this paper as: Increased levels of serum IL-31 in chronic spontaneous urticaria. Experimental Dermatology 2010.Abstract: IL-31 represents a novel cytokine involved in pruritic skin diseases including atopic dermatitis (AD). We, therefore, aimed at investigating IL-31 levels in chronic spontaneous urticaria (CU). We included 46 patients with CU, 26 non-atopic skin healthy subjects as negative and 28 patients with AD as positive controls. IL-31 serum levels were analysed using commercial ELISA kit. IL-31 serum levels were higher in patients with CU compared to healthy controls (P < 0.001), but lower compared to patients with AD (P < 0.001). There was no difference in IL-31 serum levels in autologous serum skin test positive or negative CU patients and patients with infectious tri...

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H. Pylori Often Unrelated to Children's Gastrointestinal Pain

Modern Medicine — Tue, 16 Feb 2010 00:00:00 +0100

In pediatric patients with gastrointestinal symptoms, Helicobacter pylori infection is not likely associated with recurrent abdominal pain, but it may be associated with unspecified abdominal pain and epigastric pain, according to a review published online Feb. 15 in Pediatrics. (Source: Modern Medicine)

The cag PAI is intact and functional but HP0521 varies significantly in Helicobacter pylori isolates from Malaysia and Singapore

European Journal of Clinical Microbiology & Infectious Diseases — Mon, 15 Feb 2010 18:00:36 +0100

Abstract Helicobacter pylori-related disease is at least partially attributable to the genotype of the infecting strain, particularly the presence of specific virulence factors. We investigated the prevalence of a novel combination of H. pylori virulence factors, including the cag pathogenicity island (PAI), and their association with severe disease in isolates from the three major ethnicities in Malaysia and Singapore, and evaluated whether the cag PAI was intact and functional in vitro. Polymerase chain reaction (PCR) was used to detect dupA, cagA, cagE, cagT, cagL and babA, and to type vacA, the EPIYA motifs, HP0521 alleles and oipA ON status in 159 H. pylori clinical isolates. Twenty-two strains were investigated for IL-8 induction and CagA translocation in vitro. The pr...

Moderate alcohol consumption may facilitate H. pylori elimination

MedWire News - Gastroenterology — Mon, 15 Feb 2010 14:18:31 +0100

Moderate alcohol consumption may facilitate the elimination of Helicobacter pylori, suggest researchers who found an inverse association between alcohol consumption and H. pylori seropositivity. (Source: MedWire News - Gastroenterology)

Inflammatory Processes Triggered by Helicobacter pylori Infection Cause Aberrant DNA Methylation in Gastric Epithelial Cells

Cancer Research — Mon, 15 Feb 2010 05:08:31 +0100

Cancer-associated inflammation is increasingly seen as a root drivers of disease risk and malignant progression, and induction of aberrant DNA methylation is one of the key mechanisms. (Source: Cancer Research)

Helicobacter bilis colonization of the biliary system in patients with pancreaticobiliary maljunction

British Journal of Surgery — Fri, 12 Feb 2010 00:00:00 +0100

This study investigated the prevalence of H. bilis colonization of the biliary system of patients with pancreaticobiliary maljunction (PBM).Bile juice and biliary tissue samples were collected from 17 patients with PBM and 27 controls who had benign biliary disease without PBM. DNA extracted from each biliary sample was subjected to polymerase chain reaction (PCR) analysis for H. bilis and Helicobacter pylori.PCR assays revealed that 12 of the 17 patients with PBM were positive for H. bilis DNA, compared with eight of 27 patients without PBM (P = 0·009). Among patients with PBM, H. bilis DNA was identified in six of eight children, including a 2-month-old infant, and in six of nine adults. The high prevalence of H. bilis DNA in the biliary system of patients with PBM was independent of ag...

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Helicobacter bilis colonization of the biliary system in patients with pancreaticobiliary maljunction.

The British Journal of Surgery — Fri, 12 Feb 2010 00:00:00 +0100

CONCLUSION:: H. bilis colonization of the biliary system is extremely common in patients with PBM. This may point to a role in the pathogenesis of biliary cancer. Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 20155791 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)

Helicobacter pylori BabA2 Relates With Atrophic Gastritis In Costa Rica

Health News from Medical News Today — Thu, 11 Feb 2010 09:00:00 +0100

The clinical outcome of gastric disease may involve differences in the prevalence or expression of bacterial virulence factors. Contrary to Asian studies, Western studies have disclosed associations between the presence of babA2 gene and gastric cancer. Evidence concerning BabA adhesin-associated genes is insufficient in Costa Rica, where the incidence of gastric cancer is very high, similar to Japan. The babA2 gene, which encodes BabA, may play a role in the development of gastric cancer in the Costa Rican population... (Source: Health News from Medical News Today)

Lactobacillus Improves Helicobacter Pylori Infected Gastritis

Health News from Medical News Today — Thu, 11 Feb 2010 09:00:00 +0100

Helicobacter pylori (H. pylori) are considered to be the most important etiological agents of chronic gastritis. The eradication of H. pylori depends on the combination of antibiotics and acid suppression drugs. Unfortunately, the side effects of antibiotics reduce the curative effect and treatment compliance. Probiotics provides an alternative method which can inhibit H. pylori infection efficiently without antibiotics associated side effects. A research team from China investigated the potential anti-H... (Source: Health News from Medical News Today)

Helicobacter pylori BabA2 Relates With Atrophic Gastritis In Costa Rica

Cancer / Oncology News From Medical News Today — Thu, 11 Feb 2010 09:00:00 +0100

Lactobacillus Improves Helicobacter Pylori Infected Gastritis

GastroIntestinal News From Medical News Today — Thu, 11 Feb 2010 09:00:00 +0100

Helicobacter pylori (H. pylori) are considered to be the most important etiological agents of chronic gastritis. The eradication of H. pylori depends on the combination of antibiotics and acid suppression drugs. Unfortunately, the side effects of antibiotics reduce the curative effect and treatment compliance. Probiotics provides an alternative method which can inhibit H... (Source: GastroIntestinal News From Medical News Today)

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Seeking A Vaccine For Helicobacter pylori In Chilean Patients

Health News from Medical News Today — Thu, 11 Feb 2010 08:00:00 +0100

Helicobacter pylori (H. pylori) is the causal agent of chronic gastritis, ulcer and gastric cancer. It has the potential to persist in the human stomach for decades, sometimes causing neither harm nor clinical symptoms. Nevertheless, on some occasions, depending on the host immune system and the strain causing the infection, the outcome can be very serious. To maintain the infection, the bacterium must adapt to survive the host defences. One way to accomplish this is to sequentially change the external proteins on the bacterial surface... (Source: Health News from Medical News Today)

Helicobacter pylori And EBV In Gastric Carcinomas

Health News from Medical News Today — Thu, 11 Feb 2010 08:00:00 +0100

Gastric cancer, one of the most common types of cancer, is associated with high mortality rates. In the last decades, a decrease in the worldwide incidence has been observed with some changes in the therapeutic and diagnostic options. However, the prognosis for this disease still remains poor, mainly when the diagnosis is performed at advanced stages. The therapy most effective is still surgical resection and in a significant number of cases, especially in the advanced stage, it is only palliative... (Source: Health News from Medical News Today)

Seeking A Vaccine For Helicobacter pylori In Chilean Patients

Immune System / Vaccines News From Medical News Today — Thu, 11 Feb 2010 08:00:00 +0100

Helicobacter pylori (H. pylori) is the causal agent of chronic gastritis, ulcer and gastric cancer. It has the potential to persist in the human stomach for decades, sometimes causing neither harm nor clinical symptoms. Nevertheless, on some occasions, depending on the host immune system and the strain causing the infection, the outcome can be very serious... (Source: Immune System / Vaccines News From Medical News Today)

Helicobacter pylori And EBV In Gastric Carcinomas

Cancer / Oncology News From Medical News Today — Thu, 11 Feb 2010 08:00:00 +0100

Gastric cancer, one of the most common types of cancer, is associated with high mortality rates. In the last decades, a decrease in the worldwide incidence has been observed with some changes in the therapeutic and diagnostic options. However, the prognosis for this disease still remains poor, mainly when the diagnosis is performed at advanced stages... (Source: Cancer / Oncology News From Medical News Today)

Celecoxib inhibits Helicobacter pylori colonization-related factors.

World Journal of Gastroenterology : WJG — Wed, 10 Feb 2010 17:56:41 +0100

CONCLUSION: Celecoxib inhibits flagellar motility and adherence of H. pylori to AGS cells, and destructs their normal structure in vitro. PMID: 20143463 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

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Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis.

World Journal of Gastroenterology : WJG — Wed, 10 Feb 2010 17:56:21 +0100

CONCLUSION: This meta-analysis on observational studies suggests an association between H. pylori and IDA. In RCTs, eradication of H. pylori can improve HB and SF levels but not significantly. PMID: 20143469 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Application of PCR amplicon sequencing using a single primer pair in PCR amplification to assess variations in Helicobacter pylori CagA EPIYA tyrosine phosphorylation motifs

BMC Research Notes — Wed, 10 Feb 2010 00:00:00 +0100

Conclusion: Automated capillary electrophoresis and amplicon sequencing using a single, M13- and T7-sequence-tagged primer pair in PCR amplification enabled a rapid molecular typing of cagA EPIYA motifs. Moreover, the techniques described allowed for a rapid detection of mixed H. pylori strains present in the same biopsy specimen. (Source: BMC Research Notes)

Tetracycline resistance in Chilean clinical isolates of Helicobacter pylori

Journal of Antimicrobial Chemotherapy — Tue, 09 Feb 2010 16:11:24 +0100

Conclusions The PCR-RFLP (HinfI) assay alone is unreliable for the detection of tetracycline resistance in Chilean clinical isolates of H. pylori. To that end, it must be complemented by sequencing of the 535 bp PCR fragment. (Source: Journal of Antimicrobial Chemotherapy)

New finding of the expression of Helicobacter pylori in Chilean patients

EurekAlert! - Medicine and Health — Tue, 09 Feb 2010 05:00:00 +0100

(World Journal of Gastroenterology) Helicobacter pylori (H. pylori) colonize the human stomach and present genetic mechanisms to evade the host immune response allowing their persistence in this habitat for years. A study involving 130 H. pylori strains isolated from patients living in different Chilean cities revealed that, nearly half of them carry the hopE and hopV genes. The results suggest that these genes can be turned on and off, and are likely to be involved in avoiding immune recognition. (Source: EurekAlert! - Medicine and Health)

Helicobacter pylori and EBV in gastric carcinomas

EurekAlert! - Medicine and Health — Tue, 09 Feb 2010 05:00:00 +0100

(World Journal of Gastroenterology) Mechanisms of gastric carcinogenesis are still not yet understood. Studies have linked genetic and epigenetic factors or microbiological agents to gastric cancer, but they didn't look for these events together. Dr. Ferrasi from Brazil verified the methylation profile, microsatellite instability (MSI), Helicobacter pylori status and Epstein Barr virus infection in gastric cancer samples. Intestinal and diffuse adenocarcinoma showed different methylation profiles and an association was found between methylation and Helicobacter pylori-cagA+. (Source: EurekAlert! - Medicine and Health)

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Helicobacter pylori babA2 relates with atrophic gastritis in Costa Rica

EurekAlert! - Medicine and Health — Tue, 09 Feb 2010 05:00:00 +0100

(World Journal of Gastroenterology) A research team from Costa Rica and Japan evaluated the prevalence of Helicobacter pylori (H. pylori) babA2, babB and a recombinant gene between babA2 and babB (babA2/B), and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates. They found the status of babA2 and babA2/B shows geographic differences, and that babA2 has clinical relevance in Costa Rica. (Source: EurekAlert! - Medicine and Health)

Lactobacillus improves Helicobacter pylori infected gastritis

EurekAlert! - Medicine and Health — Tue, 09 Feb 2010 05:00:00 +0100

(World Journal of Gastroenterology) A research team from China isolated two stomach originated lactobacillus strains, and screened their potential anti-Helicobacter pylori (H. pylori) activity and anti-inflammatory effects on mouse model of H. pylori-associated Balb/c gastritis. They found both lactobacillus strains have a significant anti-H. pylori activity; Lactobacillus fermenti (L. fermenti) displays more efficient antagonistic activity in vivo against H. pylori infection. (Source: EurekAlert! - Medicine and Health)

Relationship between Helicobacter pylori Tyrosine-Phosphorylated CagA-Related Markers and the Development of Diffuse-Type Gastric Cancers: A Case-Control Study

Digestion — Mon, 08 Feb 2010 23:00:00 +0100

Digestion 2010;82:1017 (DOI:10.1159/000265933) (Source: Digestion)

Relevance of Helicobacter pylori genotypes in gastric pathology and its association with plasma malondialdehyde and nitric oxide levels

Inflammopharmacology — Mon, 08 Feb 2010 17:20:03 +0100

In conclusion, the study demonstrates close relationship between the plasma malondialdehyde and nitric oxide levels, gastric histopathology and genotypes of H. pylori. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s10787-010-0031-yAuthors Santosh K. Tiwari, Deccan College of Medical Sciences Centre for Liver Research and Diagnostics Kanchanbagh Hyderabad 500 058 Andhra Pradesh IndiaG. Manoj, Deccan College of Medical Sciences Centre for Liver Research and Diagnostics Kanchanbagh Hyderabad 500 058 Andhra Pradesh IndiaVishwas Sharma, Deccan College of Medical Sciences Centre for Liver Research and Diagnostics Kanchanbagh Hyderabad 500 058 Andhra Pradesh IndiaG. Sivaram, Deccan College of Medical Sciences Centre for Liver Research and Diagnostics Kanchanbagh Hyderabad...

Oral H. pylori infection linked to oxidative stress, altered redox equilibrium

MedWire News - Gastroenterology — Mon, 08 Feb 2010 14:18:16 +0100

Helicobacter pylori infection may be associated with altered redox equilibrium, suggest researchers who found that the total antioxidant capacity of saliva samples from H. pylori-positive individuals was significantly lower than samples from non-infected individuals. (Source: MedWire News - Gastroenterology)

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Diagnosis of Helicobacter pylori (HP) in dyspepsia: Quick Reference Guide for Primary Care

Gastroenterology and Liver Diseases Specialist Library - Diagnostic procedures — Mon, 08 Feb 2010 13:59:43 +0100

Aim: To improve the diagnosis of infectious disease in primary care To improve use of the microbiology laboratory in primary care To target the use of antibiotics and anti-fungals in primary care Production: The templates have been produced in consultation with GPs and specialists in the field. They are in agreement with other guidance, including Prodigy, SIGN and NICE. The guidance is fully referenced and graded. The guidance is not all-encompassing, as it is meant to be quick reference. If more detail is required we suggest referral to the websites and references quoted. The guidance is updated annually. Local adaptation: The guidance will need to be taken forward in collaboration between laboratories, PCTs and secondary care providers. Recommendations can be changed to suit local servic...

Diagnosis of Helicobacter pylori (HP) in dyspepsia: Quick Reference Guide for Primary Care

Gastroenterology and Liver Diseases Specialist Library - Stomach — Mon, 08 Feb 2010 11:39:15 +0100

Pharmacogenetics of esomeprazole or rabeprazole-based triple therapy in Helicobacter pylori eradication in Hong Kong non-ulcer dyspepsia Chinese subjects

Journal of Clinical Pharmacy and Therapeutics — Mon, 08 Feb 2010 00:00:00 +0100

Conclusion: Triple therapy with either EAC or RAC is effective for Hong Kong Chinese NUD patients with H. pylori infection. Success eradication was related to clarithromycin resistance and not CYP2C19 genotype. (Source: Journal of Clinical Pharmacy and Therapeutics)

Upper gastrointestinal endoscopic findings in the era of highly active antiretroviral therapy

HIV Medicine — Mon, 08 Feb 2010 00:00:00 +0100

The current literature suggests that there has been a decrease in opportunistic diseases among HIV-infected patients since the widespread introduction of highly active antiretroviral therapy (HAART) in 1995. The aim of the study was to investigate the impact of HAART and CD4 lymphocyte count on diseases of the upper gastrointestinal (UGI) tract, digestive symptoms, and endoscopic and histological observations. A review of 706 HIV-infected patients who underwent GI endoscopy was undertaken. The cohort was divided into three groups: group 1 (G1), pre-HAART, consisting of 239 patients who underwent endoscopy between January 1991 and December 1994; group 2 (G2), early HAART, consisting of 238 patients who underwent endoscopy between January 1999 and December 2002; and group 3 (G3), recent HAAR...

Sibship size, Helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from Germany

International Journal of Epidemiology — Sat, 06 Feb 2010 08:02:43 +0100

Conclusions Our results suggest that large sibship size is associated with increased H. pylori prevalence and CAG risk. The association with CAG risk may be mediated at least in part by H. pylori infection. However, mechanisms other than H. pylori infection may contribute to the ‘sibling effect’ as well. (Source: International Journal of Epidemiology)

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Chemical Composition and Inhibitory Activity Against Helicobacter pylori of the Essential Oil of Apium nodiflorum (Apiaceae)

Journal of Medicinal Food — Sat, 06 Feb 2010 02:22:16 +0100

Journal of Medicinal Food Feb 2010, Vol. 13, No. 1: 228-230. (Source: Journal of Medicinal Food)

Antibacterial and Antifungal Properties of Acetonic Extract of Feijoa sellowiana Fruits and Its Effect on Helicobacter pylori Growth

Journal of Medicinal Food — Sat, 06 Feb 2010 02:21:22 +0100

Journal of Medicinal Food Feb 2010, Vol. 13, No. 1: 189-195. (Source: Journal of Medicinal Food)

Bismuth(iii) complexes derived from non-steroidal anti-inflammatory drugs and their activity against Helicobacter pylori

RSC - Dalton Trans. latest articles — Fri, 05 Feb 2010 16:24:55 +0100

Philip C. Andrews, Richard L. Ferrero, Peter C. Junk, Ish Kumar, Quynh Luu, Kim Nguyen, James W. Taylor (Paper from Dalton Trans.) Philip C. Andrews, Dalton Trans., 2010, DOI: 10.1039/c000164c To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)

H. Pylori Eradication in Peptic Ulcer Disease May up Risk of GERD

Medscape Gastroenterology Headlines — Fri, 05 Feb 2010 16:06:25 +0100

In patients with peptic ulcers, eradication of Helicobacter pylori seemed to double the risk of new-onset reflux - but only in cohort study subgroups, and not in randomized trials, according to a new meta-analysis. Reuters Health Information (Source: Medscape Gastroenterology Headlines)

Effort, safety, and findings of routine preoperative endoscopic evaluation of morbidly obese patients undergoing bariatric surgery

Surgical Endoscopy — Fri, 05 Feb 2010 08:43:12 +0100

Conclusions Upper gastrointestinal endoscopy can be performed safely. However, careful monitoring and anesthesiological support are required for patients with concomitant diseases and those receiving sedation. Because 80% of the patients with pathological findings were asymptomatic, every morbidly obese patient should undergo endoscopy before bariatric surgery because there may be findings that might change the surgical strategy. Content Type Journal ArticleDOI 10.1007/s00464-010-0893-5Authors M. A. Küper, Tübingen University Hospital Department of General, Visceral and Transplant Surgery Hoppe-Seyler-Strasse 3 72076 Tübingen GermanyT. Kratt, Tübingen University Hospital Department of General, Visceral and Transplant Surgery Hoppe-Seyler-Strasse 3 72076 Tübingen...

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Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled

Molecular Cancer — Fri, 05 Feb 2010 00:00:00 +0100

Conclusion: We analysed the Helicobacter pylori-induced activation of Wnt-signaling factors, and demonstrate for the first time that the canonical Wnt-signalling proteins LRP6 and Dvl2 and Dvl3 are involved in the regulation of beta-catenin. (Source: Molecular Cancer)

Risk of gastro-oesophageal reflux disease after Helicobacter pylori eradication: Meta-analysis

NeLM - News — Fri, 05 Feb 2010 00:00:00 +0100

Source: Am J Gastroenterol Area: News This meta-analysis investigated whether eradication of Helicobacter pylori (Hp) infection is associated with the development of new gastro-oesophageal reflux disease (GORD) in patients who had no evidence of GORD at entry. A literature search was carried out for RCTs and cohort studies (1983 to 2007) involving patients with Hp infection and with no evidence of GORD assigned into at least two groups, receiving either Hp eradication therapy or placebo. Twelve studies were identified (7 RCTs and 5 cohorts) and the following findings were reported: . In 6 RCTs using erosive GORD as outcome, the odds ratio (OR) for the frequency of GORD in Hp eradicated group vs. persistent Hp group was 1.11 (0.81 to 1.53, p = 0.52) .&...

Helicobacter pylori virulence factors as tools to study human migrations.

Toxicon — Fri, 05 Feb 2010 00:00:00 +0100

We report here a study including a set of native Amazon Amerindians that had supposedly been some, but little, contact with European Brazilian colonizer and/or African slaves. They harbor H. pylori strains in a mixed pattern with Asian and Iberian Peninsula characteristics. It is possible that this finding represents H. pylori recombination upon short contact between human groups. Alternatively, it could be due to a founder effect from a small cluster of Asian origin native Americans. PMID: 20144640 [PubMed - as supplied by publisher] (Source: Toxicon)

Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma

Clinical Chemistry and Laboratory Medicine — Thu, 04 Feb 2010 17:00:17 +0100

Conclusions: These data suggest that HSP27 is over-expressed in GA tissue and serum concentrations of HSP27 are increased in patients with GA. Over-expression of HSP27 may indicate a gastric malignant/infectious process. The detection of serum HSP27 concentrations by ELISA may be useful for screening for GA. Clin Chem Lab Med 2010;48:263–9. (Source: Clinical Chemistry and Laboratory Medicine)

Work-related Helicobacter pylori infection among sewage workers in municipal wastewater treatment plants in Belgium

Occupational and Environmental Medicine — Thu, 04 Feb 2010 16:47:11 +0100

Conclusions Our results do not suggest that H pylori infection is a probable cause of part of gastrointestinal symptoms among Flemish municipal sewage workers of WWTPs. (Source: Occupational and Environmental Medicine)

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Population screening program decreases H. pylori seroprevalence rates

MedWire News - Gastroenterology — Wed, 03 Feb 2010 14:29:30 +0100

Study findings show that a significant decline in Helicobacter pylori seroprevalence rates can be achieved with a voluntary “screen-treat-retest-and-retreat” program for young adults in the general population. (Source: MedWire News - Gastroenterology)

Role of Helicobacter pylori infection in gastric cancer pathogenesis: A chance for prevention

Chinese Journal of Digestive Diseases — Wed, 03 Feb 2010 00:00:00 +0100

Gastric cancer in the absence of strategies implemented for early detection continues to have a dismal prognosis. There are limited options for a curative therapy once patients present with clinical manifestations of this malignant disease. Helicobacter pylori (H. pylori) infection plays a key role in gastric carcinogenesis, supported by epidemiological, preclinical and clinical studies. The recognition of H. pylori infection as a critical risk factor in the development of gastric cancer opens the chance for new venues in prevention strategies. (Source: Chinese Journal of Digestive Diseases)

Prevalence of Helicobacter pylori infection among new outpatients with dyspepsia in Kuwait

BMC Gastroenterology — Wed, 03 Feb 2010 00:00:00 +0100

Conclusions: : Almost half of the patients with dyspeptic symptoms in Kuwait were positive for H. pylori, though the prevalence varied with age and was higher among expatriates. The American Gastroenterology Association guidelines recommending testing and treatment for H. pylori for patients with uninvestigated dyspepsia should be endorsed in Kuwait. (Source: BMC Gastroenterology)

Expression of UreB and HspA of Helicobacter pylori in silkworm pupae and identification of its immunogenicity.

Molecular Biology Reports — Wed, 03 Feb 2010 00:00:00 +0100

Authors: Zhang X, Shen W, Lu Y, Zheng X, Xue R, Cao G, Pan Z, Gong C For mass production of urease B subunit (UreB) and heat shock protein A subunit (HspA) of Helicobacter pylori with Bombyx mori nuclear polyhedrosis virus (BmNPV) baculovirus expression system (BES) and to determine whether they could be used as an oral vaccine against H. pylori, besides, to determine the time course of expressed recombinant protein and the optimum acquisition time directly through green fluorescence, HspA and enhanced green fluorescence protein (EGFP) genes were cloned into vector pFastBacDual to form donor vector pFastBacDual-(EGFP) (HspA), UreB gene was cloned into vector pFastBacDual to form donor vector pFastBacDual-UreB,then they were transformed into E. coli BmDH10Bac to obtain the recombinant B...

Interferon-gamma secretion is induced in IL-12 stimulated human NK cells by recognition of Helicobacter pylori or TLR2 ligands.

Innate Immunity — Wed, 03 Feb 2010 00:00:00 +0100

In conclusion, we suggest an involvement of TLR2 in the recognition of H. pylori by human NK cells and that HpaA is a TLR2 ligand important for recognition. PMID: 20130107 [PubMed - as supplied by publisher] (Source: Innate Immunity)

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Relationship between Alcohol Consumption and Active Helicobacter pylori Infection

Medscape Today Headlines — Tue, 02 Feb 2010 12:04:37 +0100

Is alcohol or smoking consumption associated with active H. pylori infection in functional dyspepsia patients? Alcohol and Alcoholism (Source: Medscape Today Headlines)

Helicobacter pylori

Pediatrics in Review — Tue, 02 Feb 2010 04:56:13 +0100

(Source: Pediatrics in Review)

Gastric reddish streaks in the intact stomach: Endoscopic feature of reactive gastropathy

Pathology International — Tue, 02 Feb 2010 00:00:00 +0100

The pathogenesis of reddish streaks in the intact stomach is unclear. Sixty-three functional dyspeptic patients with gastric reddish streaks were recruited for the study. Fifty-five patients (group I) had only reddish streaks while nine patients (group II) had additional lesions such as reddish patches or spots randomly scattered throughout the stomach. Updated Sydney system and parameters of reactive gastropathy were used to score the biopsy specimens from reddish streaks separately. Helicobacter pylori infection rate was found to be markedly lower in group I than group II patients (13% vs 89%, P < 0.001). H. pylori-infected patients had higher scores for acute and chronic inflammation (P < 0.001) and foveolar hyperplasia (P < 0.005) than non-infected patients, while other parameters for ...

Clinical trial: irsogladine maleate, a mucosal protective drug, accelerates gastric ulcer healing after treatment for eradication of Helicobacter pylori infection – the results of a multicentre, double-blind, randomized clinical trial (IMPACT study)

Alimentary Pharmacology and Therapeutics — Tue, 02 Feb 2010 00:00:00 +0100

Conclusions Irsogladine maleate was effective for treating gastric ulcer after H. pylori eradication. The high healing rates observed in patients with or without successful eradication demonstrate the usefulness of irsogladine maleate treatment regardless of the outcome of eradication. (Source: Alimentary Pharmacology and Therapeutics)

[Reflection and Reaction] Histological subtype of gastric cancer in Japan

The Lancet Oncology — Mon, 01 Feb 2010 00:00:00 +0100

In the November, 2009, issue of The Lancet Oncology, Nishida discussed the current treatment of gastric cancer in Asia. Additionally, he suggested that intestinal-type distal gastric cancer related to Helicobacter pylori is predominant in Asia, compared with proximal and diffuse types of gastric cancer which predominate in Europe and North America. Regarding histological types in Japan, Laurens classification is not commonly used in general clinical practice. Rather, gastric cancers are classified according to the Japanese Research Society Committee and are divided into papillary, tubular/well differentiated, and tubular/moderately differentiated adenocarcinoma (which together are considered well differentiated), and poorly differentiated and signet-ring adenocarcinoma (which together are ...

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In Vitro Antibacterial Activity of Phx-3 against Helicobacter pylori.

Biological and Pharmaceutical Bulletin — Mon, 01 Feb 2010 00:00:00 +0100

Authors: Hanawa T, Osaki T, Manzoku T, Fukuda M, Kawakami H, Tomoda A, Kamiya S Phx-3, one of the phenoxazine derivatives, is reported to have inhibitory effect on Mycobacterium species and Chlamydia pneumoniae but not Escherichia coli, Salmonella Typhimurium, Pseudomonas aeruginosa, Staphylococcus aureus, Listeria monocytogenes. The bactericidal activities of Phx-3 against Helicobacter pylori strains have not been assessed. Then, we measured minimum inhibitory concentration of Phx-3 for Helicobacter strains and assessed the morphological and biochemical effects of Phx-3 on H. pylori. In present study, it has shown that H. pylori strains including clarithromycin resistant strain and Helicobacter musterae were killed effectively by the treatment with Phx-3. Furthermore, severe morpholog...

Eradication of Helicobacter pylori Increases Ghrelin mRNA Expression in the Gastric Mucosa.

J Korean Med Sci — Mon, 01 Feb 2010 00:00:00 +0100

Authors: Lee ES, Yoon YS, Park CY, Kim HS, Um TH, Baik HW, Jang EJ, Lee S, Park HS, Oh SW It has been suggested that Helicobacter pylori eradication may influence production of some peptides in the stomach, which can affect appetite. This hypothesis is controversial. To verify the hypothesis, we conducted this randomized controlled trial using H. pylori infected subjects without any gastrointestinal symptoms. The treatment group received triple H. pylori eradication therapy for 7 days and the control group received no medication. We measured ghrelin, obestatin and the tumor necrosis factor-alpha (TNF-alpha) mRNA levels in endoscopic biopsy specimens and the changes from baseline to follow-up. The plasma active n-octanoyl ghrelin and obestatin levels were measured in both groups. The gh...

Medical and Endoscopic Treatment in Peptic Ulcer Bleeding: a National German Survey.

Zeitschrift fur Gastroenterologie — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSION: Medical and endoscopic treatment of bleeding ulcers reached a high standard, although some therapeutic strategies leave room for improvement. Bigger hospitals tend to be closer to the medical standard. PMID: 20127600 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Gastroenterologie)

Alcohol Consumption, Serum Gamma-Glutamyltransferase, and Helicobacter Pylori Infection in a Population-Based Study Among 9733 Older Adults.

Annals of Epidemiology — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSIONS: In conclusion, our results support the hypothesis that moderate alcohol consumption may facilitate elimination of H. pylori. PMID: 20123162 [PubMed - as supplied by publisher] (Source: Annals of Epidemiology)

[Construction of a recombinant Lactobacillus acidophilus expressing high levels of Helicobacter pylori adhesin Hp0410.]

Journal of Southern Medical University — Mon, 01 Feb 2010 00:00:00 +0100

CONCLUSION: The recombinant Lactobacillus acidophilus with high constitutive expression of Hp0410 has been constructed successfully. PMID: 20159678 [PubMed - in process] (Source: Journal of Southern Medical University)

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[Helicobacter pylori Eradication for Stage I(E1) Gastric Mucosa-associated Lymphoid Tissue Lymphoma: Predictive Factors of Complete Remission.]

Korean J Gastroenter... — Mon, 01 Feb 2010 00:00:00 +0100

Conclusions: The proximally location of MALT lymphoma is a risk factor of the H. pylori eradication treatment failure. Therefore, the proximally located gastric MALT lymphoma should be carefully treated and followed. PMID: 20168055 [PubMed - in process] (Source: Korean J Gastroenter...)

Staging role of EUS

Best Practice & Research. Clinical Gastroenterology — Mon, 01 Feb 2010 00:00:00 +0100

Type of lymphoma and stage of disease are the two decisive prognostic factors and therapeutic determinants. For the locoregional staging, i.e. assessment of the gastric wall infiltration and perigastric lymphonodular involvement, endoscopic ultrasound (EUS) is highly useful. EUS has, therefore, to be integrated into the standard staging procedure of gastric lymphoma, although its impact on initial treatment decisions might be limited in the individual case. A benefit from the use of miniechoendoscopes, EUS elastography and EUS-guided biopsies has not yet been proven in gastric lymphoma. EUS also confers an important prognostic value regarding treatment responses to Helicobacter pylori eradication. On the contrary, EUS cannot be recommended as a regular part of follow-up investigations cons...

Role of radiotherapy in the treatment of lymphomas of the gastrointestinal tract

Best Practice & Research. Clinical Gastroenterology — Mon, 01 Feb 2010 00:00:00 +0100

In patients with gastrointestinal lymphoma the most frequently involved site is the stomach (60%–75% of cases), followed by the small bowel, ileum, cecum, colon and rectum. The most common histological subtypes are extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) and diffuse large B-cell lymphoma (DLBCL). The role of radiotherapy is most definite in early stage gastric lymphoma.The therapeutic approach for patients with gastric Non Hodgkin lymphoma (NHL) has changed significantly over the last decades. The primary treatment of limited gastric MALT lymphoma consists of Helicobacter pylori eradication. In case of insufficient response to H. pylori eradication or in case H. pylori is absent, irradiation of the stomach and perigastric lymph nodes to a ...

Long-term follow-up of gastric lymphoma after stomach conserving treatment

Best Practice & Research. Clinical Gastroenterology — Mon, 01 Feb 2010 00:00:00 +0100

The therapeutic strategy in gastric lymphoma has completely changed over the last two decades. This change is mainly characterised by the abandonnement of surgery in favour of conservative therapies and the introduction of Helicobacter pylori eradication therapy. It became evident that conservative treatment with radiation and/or chemotherapy is at least as effective as surgical resection and additionally offers the advantage of stomach preservation and better quality of life. The therapeutic goal is undoubtedly complete remission of the lymphoma as a necessary basis for cure of the disease. Both radiotherapy and chemotherapy have a high curative potential in gastric MALT lymphoma and diffuse large B-cell lymphoma (DLBCL), respectively. An open question is the additional benefit of radiati...

Treponema pallidum immunostain distinguishing syphilitic gastritis from Helicobacter pylori-associated gastritis—reply

Human Pathology — Mon, 01 Feb 2010 00:00:00 +0100

We thank Drs Liu and Hameed for their interest in our study . A case of secondary syphilis mimicking Helicobacter pylori-associated gastritis is presented. The definite diagnosis was only suspected after observing a cutaneous rash clinically consistent with secondary syphilis and was confirmed by the immunohistochemical demonstration of multiple spirochetes within the lamina propria in the gastric biopsy specimen. (Source: Human Pathology)

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H. pylori infection linked to autoimmune gastritis

MedWire News - Gastroenterology — Fri, 29 Jan 2010 14:16:22 +0100

Study findings suggest that atrophic corpus gastritis, including autoimmune type severe atrophy with vitamin B12 malabsorption, is associated with longstanding Helicobacter pylori infection. (Source: MedWire News - Gastroenterology)

Impact of H. Pylori on Growth: Is the Infection or Mucosal Disease Related to Growth Impairment?

Digestive Diseases and Sciences — Fri, 29 Jan 2010 12:19:37 +0100

Conclusion Recurrent abdominal pain associated with gastric mucosal injury plays a role in a decrease in BMI independent of H. pylori infection. However, if recurrent abdominal pain originates from H. pylori infection, it appears that linear growth is also affected. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-009-1091-yAuthors Mahir Gulcan, Yeditepe University Medical Faculty Department of Pediatric Gastroenterology, Hepatology and Nutrition Istanbul TurkeyAhmet Ozen, Yeditepe University Medical Faculty Department of Pediatrics Devlet Yolu Ankara cad. No: 102-104 34752 Kozyatagi, Istanbul TurkeyHande Ozgun Karatepe, Yeditepe University Medical Faculty Department of Pediatrics Devlet Yolu Ankara cad. No: 102-104 34752 Kozyatagi, Istanbul Turke...

Helicobacter pylori Eradication Prevents Extension of Intestinalization Even in the High-Risk Group for Gastric Cancer

Digestion — Thu, 28 Jan 2010 23:00:00 +0100

Digestion 2010;81:223230 (DOI:10.1159/000264651) (Source: Digestion)

Helicobacter pylori Eradication Prevents Extension of Intestinalization Even in the High-Risk Group for Gastric Cancer

Digestion — Thu, 28 Jan 2010 23:00:00 +0100

Digestion 2010;81:223230 (DOI:10.1159/000264651) (Source: Digestion)

Lab Test Beats In-Office Tests for Diagnosing H. Pylori

Medscape Medical News Headlines — Thu, 28 Jan 2010 18:17:07 +0100

Amplified IDEIA Hp StAR (Oxoid), a laboratory enzyme immunoassay, is more accurate than in-office immunochromatographic stool tests in diagnosing Helicobacter pylori infection, new research suggests. Reuters Health Information (Source: Medscape Medical News Headlines)

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Can Ulcers Lead to Cancer?

NYT > Health — Thu, 28 Jan 2010 15:51:23 +0100

Helicobacter pylori, the bacterium linked to ulcers, plays a role in stomach cancer, though scientists still do not fully understand why some people get gastric cancer and others do not. (Source: NYT > Health)

Mucosal patterns of Helicobacter pylori-related gastritis without atrophy in the gastric corpus using standard endoscopy.

World Journal of Gastroenterology : WJG — Thu, 28 Jan 2010 00:00:00 +0100

CONCLUSION: Our study suggests that mucosal patterns in H. pylori-infected gastric mucosa without atrophy can be reliably identified using standard endoscopy in the gastric corpus. PMID: 20101778 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan.

World Journal of Gastroenterology : WJG — Thu, 28 Jan 2010 00:00:00 +0100

CONCLUSION: These results suggest that the status of babA2 and babA2/B shows geographic differences, and that babA2 has clinical relevance in Costa Rica. PMID: 20101774 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Two stomach-originated lactobacillus strains improve Helicobacter pylori infected murine gastritis.

World Journal of Gastroenterology : WJG — Thu, 28 Jan 2010 00:00:00 +0100

CONCLUSION: Both lactobacillus strains have a significant anti-H. pylori activity; L. fermenti displays more efficient antagonistic activity in vivo against H. pylori infection. PMID: 20101769 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Gastric ulcer bacteria turn immune defense inwards

ScienceDaily Headlines — Wed, 27 Jan 2010 07:00:00 +0100

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Identification of Helicobacter spp. in bile and gallbladder tissue of patients with symptomatic gallbladder disease

HPB: official journal of the International Hepato Pancreat Biliary Association — Wed, 27 Jan 2010 00:00:00 +0100

Discussion: Helicobacter spp. can be detected in bile and gallbladder tissue of patients with benign gallbladder disease. The contribution of these bacteria to the pathophysiology of gallbladder disease and gallstone formation requires further study. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)

Helicobacter pylori lingers in tissues

Health News - UPI.com — Tue, 26 Jan 2010 21:13:39 +0100

GOTHENBURG, Sweden, Jan. 26 (UPI) -- A Swedish researcher has figured out how gastric ulcer bacteria sabotage body immunity and the discovery may lead to a vaccine for stomach cancer. (Source: Health News - UPI.com)

Gastric Ulcer Bacteria Turn Immune Defence Inwards

Immune System / Vaccines News From Medical News Today — Tue, 26 Jan 2010 10:00:00 +0100

Gastric Ulcer Bacteria Turn Immune Defence Inwards

Health News from Medical News Today — Tue, 26 Jan 2010 10:00:00 +0100

Despite a strong response from our immune defence, the body is unable to rid itself of the bacterium Helicobacter pylori. One reason for this is that this bacterium encourages elements of the immune response to remain in tissue, activating the wrong immune cells. Research results that pave the way for a future vaccine are now being published by the Sahlgrenska Academy at the University of Gothenburg, Sweden. Approximately half of the world's population are infected with Helicobacter pylori, found primarily in the stomach... (Source: Health News from Medical News Today)

MedWorm: Helicobacter Pylori

MISHIMA - a new method for high speed multiple alignment of nucleotide sequences of bacterial genome scale data

Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?

The chemical-in-plug bacterial chemotaxis assay is prone to false positive responses

Treponema pallidum immunostain distinguishing syphilitic gastritis from Helicobacter pylori-associated gastritis

Using Antibiotics To Prevent Gastric Cancer

Using Antibiotics To Prevent Gastric Cancer

Does Cholesterol Really Matter?

Genetic polymorphisms in DNA repair genes XPC, XPD, and XRCC4, and susceptibility to Helicobacter pylori infection-related gastric antrum adenocarcinoma in Guangxi population, China

Association between Helicobacter pylori infection and gastroduodenal lesions in patients with chronic liver disease

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System

Adverse effects of proton pump inhibitors

Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer.

Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas.

Influence of efflux pump inhibitors on the multidrug resistance of Helicobacter pylori.

Preventing gastric cancer with antibiotics

Preventing gastric cancer with antibiotics

Association of c.802C>T polymorphism of NOD2/CARD15 gene with the chronic gastritis and predisposition to cancer in H. pylori infected patients.

In vitro susceptibility to antimicrobial agents and ultrastructural characteristics related to swimming motility and drug action in Campylobacterjejuni and C. coli

Prescreening of a High-Risk Group for Gastric Cancer by Serologically Determined Helicobacter pylori Infection and Atrophic Gastritis

Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen

Molecular detection of host cytokine expression in

Short-duration furazolidone therapy in combination with amoxicillin, bismuth subcitrate, and omeprazole for eradication of

Type 2 diabetes mellitus: A risk factor for

Breastfeeding protects children against peptic ulcer bacterium

Calbiotech Inc - H. Pylori IgM ELISA 96 Well Kit - Class 2 Recall

Calbiotech Inc - H. Pylori IgA ELISA 96 Well Kit - Class 2 Recall

Etiological approach to chronic urticaria

Bismuth-Based First-Line Therapy for Helicobacter pylori Eradication in Type 2 Diabetes Mellitus Patients

Helicobacter pylori with or without its neutrophil-activating protein may be the common denominator associated with multiple sclerosis and neuromyelitis optica

Authors' reply to 'Helicobacter pylori with or without its neutrophil-activating protein may be the common denominator associated with multiple sclerosis and neuromyelitis optica'

Gene regulation: Can we stomach it? New technique fights against cause of peptic ulcer disease and gastric cancer

Direct repression of sonic hedgehog expression in the stomach by Cdx2 leads to intestinal transformation

Direct repression of sonic hedgehog expression in the stomach by Cdx2 leads to intestinal transformation.

Role of Probiotics in Pediatric Patients with Helicobacter pylori Infection: A Comprehensive Review of the Literature

Associations Between Helicobacter pylori Infection, Co-Morbid Infections, Gastrointestinal Symptoms, and Circulating Cytokines in African Children

Presence of Helicobacter pylori in a Sibling is Associated with a Long-Term Increased Risk of H. pylori Infection in Israeli Arab Children

Type I Restriction–Modification Loci Reveal High Allelic Diversity in Clinical Helicobacter pylori Isolates

Comparison of the Efficacy of the Two Tetracycline-Containing Sequential Therapy Regimens for the Eradication of Helicobacter Pylori: 5 days Versus 14 days Amoxicillin

Ten-Day Sequential Therapy as First-line Treatment for Helicobacter pylori Infection in Korea: A Retrospective Study

A Randomized Controlled Trial: Efficacy and Safety of Azithromycin, Ofloxacin, Bismuth, and Omeprazole Compared With Amoxicillin, Clarithromycin, Bismuth, and Omeprazole as Second-Line Therapy in Patients With Helicobacter pylori Infection

The Continuous Story of Helicobacter pylori Infection and Insulin Resistance: This Time in Japan

Major Health Risks in Aging Persons With Intellectual Disabilities: An Overview of Recent Studies

Helicobacter pylori acidic stress response factor HP1286 is a YceI homolog with new binding specificity

Could Helicobacter pylori play an important role in axonal type of Guillain-Barré Syndrome pathogenesis?

Dual proton pump inhibitor plus amoxicillin as an empiric anti-H. pylori therapy: studies from the United States

Breastfeeding Protects Children Against Peptic Ulcer Bacterium

Breastfeeding Protects Children Against Peptic Ulcer Bacterium

Helicobacter pylori and its role in vocal folds' minimal lesions

A preliminary approach to creating an overview of lactoferrin multi-functionality utilizing a text mining method.

Association Between Helicobacter pylori and Gastrointestinal Symptoms in Children

Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology.

The study on the antibacterial activity of compounds from the isodon species.

In vitro Antibacterial and Morphological Effects of the Urushiol Component of the Sap of the Korean lacquer tree (Rhus vernicifera Stokes) on Helicobacter pylori.

Endoscopic-Bioptic Diagnostics, Surveillance of and Therapy for Gastrointestinal Diseases According to Guidelines.

Med Sci Monit 2010; 16(3):CR144-148 "Recurrence of Helicobacter pylori infection 1 year after successful eradication: A prospective study in Northern Iran"

Book Review: Helicobacter pylori: Molecular Genetics and Cellular Biology

Gene Regulation: Can We Stomach It?

Gene Regulation: Can We Stomach It?

Treating H. Pylori Bacteria Effective for Gastric Lymphoma

The Role of Infection in Carotid Plaque Pathogenesis and Stability: The Clinical Evidence.

Stomach-Specific Controlled Release Gellan Beads of Acid-Soluble Drug Prepared by Ionotropic Gelation Method.

Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan

Gene regulation: Can we stomach it?

Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin

H. pylori-induced promoter hypermethylation downregulates USF1 and USF2 transcription factor gene expression

Review Found No Link Between Pediatric Abdominal Pain and H pylori Infection

High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period

Type 2 diabetes mellitus: A risk factor for <i>Helicobacter pylori</i> infection: A hospital based case-control study

Efficacy of Standard Triple Therapy in the Treatment of Helicobacter pylori Infection: Experience from Kuwait

Characterization of an N6 adenine methyltransferase from Helicobacter pylori strain 26695 which methylates adjacent adenines on the same strand

Complexity of Gastric Acid Secretion Revealed by Targeted Gene Disruption in Mice.

The primary transcriptome of the major human pathogen Helicobacter pylori

The primary transcriptome of the major human pathogen Helicobacter pylori

Carotid Plaque Thickness Tied to Past Infections

CDKN2A promoter methylation is related to the tumor location and histological subtype and associated with Helicobacter pylori flaA(+) strains in gastric adenocarcinomas

Increased levels of serum IL-31 in chronic spontaneous urticaria*

H. Pylori Often Unrelated to Children's Gastrointestinal Pain

The cag PAI is intact and functional but HP0521 varies significantly in Helicobacter pylori isolates from Malaysia and Singapore

Moderate alcohol consumption may facilitate H. pylori elimination