MedWorm: Bone Marrow Transplant

California Man Uses Social Media To Find Bone Marrow Donor

Thu, 09 Feb 2012 04:53:42 +0100

BOSTON (CBS) – Amit Gupta says social media helped save his life. The 32-year-old San Francisco Internet entrepreneur spoke with WBZ from his room at Brigham and Women’s Hospital in Boston. “It’s kind of amazing that this came together the way it did,” says Gupta. “I can’t imagine this happening without Twitter or Facebook or Tumblr. It just wouldn’t have been possible to meet so many people so quickly.” Gupta was diagnosed with Leukemia in September. To live, he needed a bone marrow transplant. Since he’s Indian American, he says his chances of finding the perfect match he needed were slim…some estimate one in 20,000. He turned to social media to get the word out, and his friends in the tech industry even raised a $30,000 r...

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Fecal calprotectin in allogeneic stem cell transplantation for the diagnosis of acute intestinal graft versus host disease

Bone Marrow Transplantation — Mon, 06 Feb 2012 05:00:00 +0100

Authors: M Bastos Oreiro, C Castilla-Llorente, A L de la Guía, R de Paz, M Van Domselaar, J Nieto, A Rodriguez, D Gallardo & M Canales (Source: Bone Marrow Transplantation)

High-dose corticosteroids with or without etanercept for the treatment of idiopathic pneumonia syndrome after allo-SCT

Bone Marrow Transplantation — Mon, 06 Feb 2012 05:00:00 +0100

Authors: R Tizon, N Frey, D F Heitjan, K S Tan, S C Goldstein, E O Hexner, A Loren, S M Luger, R Reshef, D Tsai, D Vogl, J Davis, M Vozniak, B Fuchs, E A Stadtmauer & D L Porter (Source: Bone Marrow Transplantation)

The increase from 2.5 to 5 mg/kg of rabbit anti-thymocyte-globulin dose in reduced intensity conditioning reduces acute and chronic GVHD for patients with myeloid malignancies undergoing allo-SCT

Bone Marrow Transplantation — Mon, 06 Feb 2012 05:00:00 +0100

The increase from 2.5 to 5 mg/kg of rabbit anti-thymocyte-globulin dose in reduced intensity conditioning reduces acute and chronic GVHD for patients with myeloid malignancies undergoing allo-SCT Bone Marrow Transplantation advance online publication, February 6, 2012. doi:10.1038/bmt.2012.3 Authors: R Devillier, R Crocchiolo, L Castagna, S Fürst, J El Cheikh, C Faucher, T Prebet, A Etienne, C Chabannon, N Vey, B Esterni & D Blaise (Source: Bone Marrow Transplantation)

Growth factor‐associated graft‐versus‐host disease and mortality 10 years after allogeneic bone marrow transplantation

British Journal of Haematology — Thu, 02 Feb 2012 05:00:00 +0100

This study analysed the effects of growth factor on outcome after haematopoietic stem‐cell transplantation (HSCT) with >9 years follow‐up. Of 1887 adult patients with acute leukaemia who received bone marrow from human leucocyte antigen (HLA)‐identical siblings and were treated with myeloablative conditioning, 459 (24%) were treated with growth factor. Growth factor hastened engraftment of neutrophils (P < 0·0001), but reduced platelet counts (P = 0·0002). Graft‐versus‐host disease (GVHD)‐free survival (no acute GVHD grade II–IV or chronic GVHD) at 10 years was 12 ± 2% (±SE) in the growth factor group, as opposed to 17 ± 2% in the controls [hazard ratio (HR) 0·81, P = 0·001]. Similar differences in GVHD‐free survival were seen in patients with or wi...

Mechanisms of Alloimmunization and Subsequent Bone Marrow Transplantation Rejection Induced by Platelet Transfusion in a Murine Model

American Journal of Transplantation — Thu, 02 Feb 2012 05:00:00 +0100

For many nonmalignant hematological disorders, HLA‐matched bone marrow transplantation (BMT) is curative. However, due to lack of neoplasia, the toxicity of stringent conditioning regimens is difficult to justify, and reduced intensity conditioning is used. Unfortunately, current reduced intensity regimens have high rates of BMT rejection. We have recently reported in a murine model that mHAs on transfused platelet products induce subsequent BMT rejection. Most nonmalignant hematological disorders require transfusion support prior to BMT and the rate of BMT rejection in humans correlates with the number of transfusions given. Herein, we perform a mechanistic analysis of platelet transfusion‐induced BMT rejection and report that unlike exposure to alloantigens during transplantation, pl...

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The potential benefits of participating in early‐phase clinical trials in multiple myeloma: long‐term remission in a patient with relapsed multiple myeloma treated with 90 cycles of lenalidomide and bortezomib

European Journal of Haematology — Wed, 01 Feb 2012 05:00:00 +0100

We present the case of a woman with relapsed multiple myeloma (MM) who received combination lenalidomide and bortezomib treatment for 90 cycles followed by continuous lenalidomide monotherapy and has completed over 100 cycles of treatment to date. The patient was diagnosed with advanced stage, symptomatic MM in 2001. Following a partial response (PR) to dexamethasone in combination with pamidronate and thalidomide, the patient underwent protocol‐directed non‐myeloablative allogeneic bone marrow transplantation from her matched sibling donor the following year. In 2004, the patient relapsed and was enrolled in a phase I, dose escalation trial of lenalidomide plus bortezomib for relapsed and refractory MM. After 8 cycles of study treatment, the patient achieved a minimal response. The pa...

Synergistic effects of CNS‐directed gene therapy and bone marrow transplantation in the murine model of infantile neuronal ceroid lipofuscinosis

Annals of Neurology — Wed, 01 Feb 2012 05:00:00 +0100

New cell-therapy technique may obviate stem-cell research

Physics Today News Picks — Tue, 31 Jan 2012 05:00:00 +0100

BBC: Researchers at Stanford University School of Medicine have succeeded in converting mouse skin cells into "neural precursor" cells, which can develop into three types of brain cell. The group's findings, which have been published in the Proceedings of the National Academy of Sciences, may be important for certain medical therapies, such as bone marrow transplants. Until now such transplants have relied on stem cells, which can divide and differentiate into many different specialized cell types. Stem-cell research has been hampered by ethical concerns, however, because one source of the cells has been human embryos. More work will have to be done to re-create the experiment using human skin cells. (Source: Physics Today News Picks)

New cell-development technique may obviate need for stem-cell research

Physics Today News Picks — Tue, 31 Jan 2012 05:00:00 +0100

BBC: Researchers at the Stanford University School of Medicine have succeeded in converting mouse skin cells into "neural precursor" cells, which can develop into three types of brain cell. The group's findings, published in the Proceedings of the National Academy of Sciences, may be important for certain medical therapies, such as bone marrow transplants. Until now such transplants have relied on stem cells, which can divide and differentiate into many different specialized cell types. Stem-cell research has been hampered by ethical concerns, however, because one source of the cells has been human embryos. More work will have to be done to re-create the experiment using human skin cells. (Source: Physics Today News Picks)

Dental Implants in Patient with Graft Versus Host Disease: Guidance?

Dental Implants Discussed by Experts — Sun, 29 Jan 2012 03:05:16 +0100

I have a new dental implant patient who presents with a history of leukemia and a bone marrow transplant. He is currently suffering from graft versus host disease. (Source: Dental Implants Discussed by Experts)

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[Comment] Neonatal screening for lysosomal storage disorders

LANCET — Sat, 28 Jan 2012 05:00:00 +0100

Lysosomal storage disorders are a diverse group of more than 50 serious, progressive diseases. Until recently, treatment was symptomatic with the expected outcomes of great disability and premature death. Improvements in bone-marrow transplantation and development of recombinant enzyme replacement therapies for some of these disorders have raised the expectation that neonatal screening could enable early treatment before irreversible damage occurs. The greatly improved early outcomes of infants treated soon after birth following identification through the Taiwanese Pompe's disease screening programme add support to this contention, but long-term data are not yet available. (Source: LANCET)

Total Hip Arthroplasty in Mucopolysaccharidosis Type IH

Advances in Pharmacological Sciences — Thu, 26 Jan 2012 18:56:20 +0100

We present the case of a 23-year-old woman with a diagnosis of Hurler syndrome with a satisfactory result following uncemented total hip arthroplasty. (Source: Advances in Pharmacological Sciences)

Blood-Forming Stem Cells' Growth Identified

Health News from Medical News Today — Thu, 26 Jan 2012 09:00:00 +0100

Scientists with the new Children's Research Institute at UT Southwestern Medical Center have identified the environment in which blood-forming stem cells survive and thrive within the body, an important step toward increasing the safety and effectiveness of bone-marrow transplantation. Institute investigators led by Dr. Sean Morrison asked which cells are responsible for the microenvironment that nurtures haematopoietic stem cells, which produce billions of new blood cells every day. The answer: endothelial and perivascular cells, which line blood vessels... (Source: Health News from Medical News Today)

Survival rates for pediatric bone marrow transplants top in nation

EurekAlert! - Medicine and Health — Thu, 26 Jan 2012 05:00:00 +0100

(University of California - San Francisco) The UCSF Benioff Children's Hospital has the best overall survival rates in the nation for bone marrow transplants, according to a recent independent review of 156 programs nationwide. (Source: EurekAlert! - Medicine and Health)

UCSF Is "Over Performer" in Bone Marrow Transplant Survival Rates

UCSF Medical Center — Thu, 26 Jan 2012 05:00:00 +0100

The Hematology and Blood and Marrow Transplant (BMT) Program at UCSF Medical Center was again named an "over performer" by the Center for International Blood and Marrow Transplant Research (CIBMTR). This is the second consecutive year the service has been recognized as an over performer. (Source: UCSF Medical Center)

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[Practice assessment in platelet transfusions.]

Transfusion Clinique et Biologique — Wed, 25 Jan 2012 05:00:00 +0100

CONCLUSION: Globally, with regard to transfusion threshold, guidelines were followed in 71%, and 93% in oncological units. Transfusion efficacy, attested by post-transfusion platelet efficiency was above 20% in 59% of the cases. These data highlight a good respect of the transfusion thresholds in the usual platelets-consuming units, but raise the question of the dose, often under those proposed by the guidelines. PMID: 22284451 [PubMed - as supplied by publisher] (Source: Transfusion Clinique et Biologique)

Antibodies to anti-thymocyte globulin in aplastic anemia patients have a negative impact on hematopoietic SCT

Bone Marrow Transplantation — Mon, 23 Jan 2012 05:00:00 +0100

Authors: C M Jol-van der Zijde, R G M Bredius, A M Jansen-Hoogendijk, F J Smiers, A C Lankester & M J D van Tol (Source: Bone Marrow Transplantation)

Posterior Reversible Encephalopathy Syndrome

Journal of Intensive Care Medicine — Mon, 23 Jan 2012 05:00:00 +0100

Posterior reversible encephalopathy syndrome (PRES) is characterized by headache, altered mental status, visual disturbances, and seizures. Radiological features typically include edema of the posterior cerebral regions, especially of the parietooccipital lobes. Atypical imaging features, such as involvement of anterior cerebral regions, deep white matter, and the brain stem are also frequently seen. Vasoconstriction is common in vascular imaging. Different conditions have been associated with PRES, but toxemia of pregnancy, solid organ or bone marrow transplantation, immunosuppressive treatment, cancer chemotherapy, autoimmune diseases, and hypertension are most commonly described. The pathophysiology of PRES is unclear and different hypotheses are being discussed. Posterior reversible en...

Radiation Disasters: Role of the BMT Team. - Confer DL, Weisdorf D, Weinstock D, Case C, Chao N.

SafetyLit: All (Unduplicated) — Sat, 21 Jan 2012 12:05:52 +0100

Bone marrow transplant (BMT) teams do not generally consider themselves to be emergency responders. But the bone marrow is the most radiosensitive organ in the body, and early changes in peripheral blood counts remain the best indicator of major total-body... (Source: SafetyLit: All (Unduplicated))

Potential New Approach For Treating Graft-Versus-Host-Disease Provided By Natural Enzyme

Health News from Medical News Today — Thu, 19 Jan 2012 08:00:00 +0100

A natural enzyme derived from human blood plasma showed potential in significantly reducing the effects of graft-vs.-host disease, a common and deadly side effect of lifesaving bone marrow transplants. Researchers from the University of Michigan Comprehensive Cancer Center looked at the drug alpha-1-antitrypsin, which is approved by the U.S. Food and Drug Administration for use in people who have a genetic mutation that makes them deficient in a certain enzyme. This drug has been used in many of these patients over extended periods of time and is known to cause minimal side effects... (Source: Health News from Medical News Today)

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Acute Leukemic Manifestation of Recurrent Anaplastic Large-Cell Lymphoma 20 Years After Autologous Bone Marrow Transplantation [DIAGNOSIS IN ONCOLOGY]

Journal of Clinical Oncology — Wed, 18 Jan 2012 05:00:00 +0100

(Source: Journal of Clinical Oncology)

Natural enzyme provides potential new approach for treating graft-vs.-host disease

ScienceDaily Headlines — Tue, 17 Jan 2012 19:42:42 +0100

Rituximab-induced direct inhibition of T-cell activation

Cancer Immunology, Immunotherapy — Tue, 17 Jan 2012 07:12:33 +0100

Conclusion Rituximab administration results in transient, dose-dependent T-cell inactivation. This effect is obtained even in B-cell absence and may increase the infection risk. Content Type Journal ArticleCategory Original articlePages 1-9DOI 10.1007/s00262-011-1168-2Authors Dina Stroopinsky, Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, P.O. Box 9602, 31096 Haifa, IsraelTamar Katz, Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, P.O. Box 9602, 31096 Haifa, IsraelJacob M. Rowe, Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, P.O. Box 9602, 31096 Haifa, IsraelDoron Melamed, Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haif...

Natural enzyme provides potential new approach for treating graft-vs.-host disease

EurekAlert! - Medicine and Health — Tue, 17 Jan 2012 05:00:00 +0100

(University of Michigan Health System) A natural enzyme derived from human blood plasma showed potential in significantly reducing the effects of graft-vs.-host disease, a common and deadly side effect of lifesaving bone marrow transplants. (Source: EurekAlert! - Medicine and Health)

Successful bone marrow transplantation for DOCK8 deficient hyper IgE syndrome

Pediatric Transplantation — Tue, 17 Jan 2012 05:00:00 +0100

(Source: Pediatric Transplantation)

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Bone marrow transplantation enhances trafficking of host-derived myelomonocytic cells that rescue intestinal mucosa after whole body radiation.

Tue, 17 Jan 2012 05:00:00 +0100

CONCLUSIONS: Besides rescuing injured BM from aplasia, BMT triggers trafficking of host CD11b(+) myelomonocytic cells from the host marrow to the radiation-injured intestinal mucosa, enhancing the proliferation of intestinal stroma cells, leading secondarily to epithelial regeneration. PMID: 22260849 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)

Expression of fetal hemoglobin in adult humans exposed to high altitude hypoxia.

Blood Cells, Molecules and Diseases — Tue, 17 Jan 2012 05:00:00 +0100

Authors: Risso A, Fabbro D, Damante G, Antonutto G Abstract In humans, acute erythroid expansion can lead to maturation of red blood cell (RBC) precursors containing fetal hemoglobin (F red cells). This can occur in patients after recovery from bone marrow transplantation, or in individuals affected by sickle cell or thalassemic syndromes. An accelerated erythroid lineage expansion is also a hallmark of the adaptive response to high altitude hypoxia. To explore the possible effect of this environment on F red cell production, we analyzed RBCs from five subjects during and after 17days spent at high altitude and investigated the expression of fetal hemoglobin by different methodological approaches. By flow cytometry, we found a moderate increase of circulating F red cells during and...

Unrelated cord blood transplantation for newly diagnosed patients with severe acquired aplastic anemia using a reduced-intensity conditioning: high graft rejection, but good survival

Bone Marrow Transplantation — Mon, 16 Jan 2012 05:00:00 +0100

Authors: H-L Liu, Z-M Sun, L-Q Geng, X-B Wang, K-Y Ding, B-I Tang, J Tong & Z-Y Wang (Source: Bone Marrow Transplantation)

A reduced intensity conditioning regimen of fludarabine, cyclophosphamide, antithymocyte globulin, plus 2 Gy TBI facilitates successful hematopoietic cell engraftment in an adult with dyskeratosis congenita

Bone Marrow Transplantation — Mon, 16 Jan 2012 05:00:00 +0100

Authors: M A Kharfan-Dabaja, Z K Otrock, A Bacigalupo, R A Mahfouz, F Geara & A Bazarbachi (Source: Bone Marrow Transplantation)

Induction of multiple myeloma-reactive T cells during post-transplantation immunotherapy with donor lymphocytes and recipient DCs

Bone Marrow Transplantation — Mon, 16 Jan 2012 05:00:00 +0100

Authors: K Broen, A Greupink-Draaisma, H Fredrix, N Schaap & H Dolstra (Source: Bone Marrow Transplantation)

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Constrictive pericarditis and primary effusion lymphoma following allogeneic BMT for CML

Bone Marrow Transplantation — Mon, 16 Jan 2012 05:00:00 +0100

Authors: H Rose, M Kulik, R Standish, E Prewett, R McLennan, J Szer & P Campbell (Source: Bone Marrow Transplantation)

Outcomes of lymphoma in South Australia, 1977-2007.

Med J Aust — Mon, 16 Jan 2012 05:00:00 +0100

CONCLUSION: Outcomes in patients with NHL have improved significantly, most likely because of the use of bone marrow transplantation and rituximab. Hospital- and state-based cancer registry data reflect the reality of population outcomes and the impact of new technologies. PMID: 22256936 [PubMed - in process] (Source: Med J Aust)

Overexpression of Angiopoietin-1 Results in Mobilization and Recruitment of Endothelial Progenitor Cells Specifically to Ischemic Tissue

Journal of Surgical Research — Sat, 14 Jan 2012 22:30:03 +0100

Introduction: We previously demonstrated that over-expression of Angiopoietin-1(Ang-1) in a murine hind limb ischemia model results in enhanced neovascularization and an increase in the number of endothelial progenitor cells (EPCs) in the ischemic limb. Ang-1 is known to induce EPC mobilization, but these findings led us to hypothesize that Ang-1 may also function to recruit EPCs to sites of ischemia. to test this hypothesis, we utilized a bone marrow transplant (BMT) model where bone marrow derived EPCs (TIE-2+ve) also express LacZ. Methods: Lethally irradiated FVB/N mice were reconstituted with BM from syngeneic transgenic TIE-2/LacZ mice. After engraftment (confirmed by flow cytometry), BMT mice underwent femoral artery ligation in the left hind limb. Ischemic quadriceps (ipsilateral) o...

Allogeneic hematopoietic stem cell transplantation in patients with diffuse large B cell lymphoma relapsed after autologous stem cell transplantation: A GITMO study

Annals of Hematology — Fri, 13 Jan 2012 16:58:16 +0100

Abstract Patients who relapse after an autologous hematopoietic stem cell transplantation (SCT) have a very poor prognosis. We have retrospectively analyzed diffuse large B cell lymphoma patients who underwent an allo-SCT after an auto-SCT relapse reported in the Gruppo Italiano Trapianto di Midollo Osseo (GITMO) database. From 1995 to 2008, 3449 autologous transplants were reported in the GITMO database. Eight hundred eighty-four patients relapsed or progressed after transplant; 165 patients, 19% of the relapsed patients, were treated with allo-transplant. The stem cell donor was related to the patient in 108 cases. A reduced intensity conditioning regimen was used in 116. After allo-SCT, 72 patients (43%) obtained a complete response and 9 obtained a partial response wit...

Management of the Diabetic Foot With Critical Limb IschemiaManagement of the Diabetic Foot With Critical Limb Ischemia

Medscape Today Headlines — Fri, 13 Jan 2012 04:00:00 +0100

Is autologous bone marrow transplantation an option for diabetic foot syndrome? Therapeutic Advances in Endocrinology and Metabolism (Source: Medscape Today Headlines)

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Young UCLA leukemia patient launches kid-friendly cookbook, hosts book signing

UCLA Newsroom: Health Sciences — Wed, 11 Jan 2012 22:00:00 +0100

(Editors: B-roll available of Jack Witherspoon in hospital recovering from bone marrow transplant.) WHAT: Jack Witherspoon, an 11-year-old aspiring chef who has battled leukemia three times and recently underwent a successful bone marrow transplant at Mattel Children's Hospital UCLA, will sign copies of his new cookbook, "Twist It Up" (Chronicle Books), written to inspire kids to have fun cooking. More than 300 guests are expected at the book launch, which will include samples of Jack's favorite recipes. Jack's mentor and friend, celebrity chef Fabio Viviani (Bravo's "Top Chef"), will attend the event. WHEN: 3:30 p.m., Sunday, Jan. 22 WHERE: HT Grill, 1701 S. Catalina Ave., Redondo Beach, Calif. 90277 (map) ...

Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation [Medical Sciences]

Proceedings of the National Academy of Sciences — Tue, 10 Jan 2012 05:00:00 +0100

Acute graft-versus-host disease (GvHD) is a major complication that prevents successful outcomes after allogeneic bone marrow transplantation (BMT), an effective therapy for hematological malignancies. Several studies demonstrate that donor T cells and host antigen-presenting cells along with several proinflammatory cytokines are required for the induction of GvHD and contribute to its severity. Increasing evidence demonstrates that human serum-derived αalpha-1- anti-trypsin (AAT) reduces production of proinflammatory cytokines, induces anti-inflammatory cytokines, and interferes with maturation of dendritic cells. Using well-characterized mouse models of BMT, we have studied the effects of AAT on GvHD severity. Administration of AAT early after BMT decreased mortality in three models of ...

Newborn screening for lysosomal diseases: current status and potential interface with population medical genetics in Latin America

Journal of Inherited Metabolic Disease — Mon, 09 Jan 2012 19:34:48 +0100

Abstract The aim of newborn screening (NBS) programs is to detect a condition in a presymptomatic baby and provide management measures which could significantly improve the natural history of the disease. NBS programs for metabolic diseases were first introduced in North America and Europe and in the 1960s for phenylketonuria, expanded a few years later to include congenital hypothyroidism, and have been growing steadily in terms of number of conditions tested for and number of countries and births covered. Lysosomal storage diseases (LSDs) are a group of around 50 genetic conditions in which a defect in a lysosomal function occurs. LSDs are progressive conditions, being usually asymptomatic at birth, but with clinical features becoming apparent in childhood, with severe m...

Enteral nutrition: a first option for nutritional support of children following allo-SCT?

Bone Marrow Transplantation — Mon, 09 Jan 2012 05:00:00 +0100

Enteral nutrition: a first option for nutritional support of children following allo-SCT? Bone Marrow Transplantation advance online publication, January 9, 2012. doi:10.1038/bmt.2011.248 Authors: S Azarnoush, B Bruno, L Beghin, D Guimber, B Nelken, I Yakoub-Agha & D Seguy (Source: Bone Marrow Transplantation)

The role of HLA antibodies in allogeneic SCT: is the ‘type-and-screen’ strategy necessary not only for blood type but also for HLA?

Bone Marrow Transplantation — Mon, 09 Jan 2012 05:00:00 +0100

The role of HLA antibodies in allogeneic SCT: is the ‘type-and-screen’ strategy necessary not only for blood type but also for HLA? Bone Marrow Transplantation advance online publication, January 9, 2012. doi:10.1038/bmt.2011.249 Authors: S Yoshihara, K Taniguchi, H Ogawa & H Saji (Source: Bone Marrow Transplantation)

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Patients receiving HLA-haploidentical/partially matched related allo-HSCT can achieve desirable HRQoL that is comparable to that of patients receiving HLA-identical sibling allo-HSCT

Bone Marrow Transplantation — Mon, 09 Jan 2012 05:00:00 +0100

Patients receiving HLA-haploidentical/partially matched related allo-HSCT can achieve desirable HRQoL that is comparable to that of patients receiving HLA-identical sibling allo-HSCT Bone Marrow Transplantation advance online publication, January 9, 2012. doi:10.1038/bmt.2011.250 Authors: X-D Mo, L-P Xu, D-H Liu, Y-H Chen, W Han, X-H Zhang, H Chen, Y Wang, J-Z Wang, K-Y Liu & X-J Huang (Source: Bone Marrow Transplantation)

A constitutional variant in the transcription factor EP300 strongly influences the clinical outcome of patients submitted to allo-SCT

Bone Marrow Transplantation — Mon, 09 Jan 2012 05:00:00 +0100

Authors: B Martín-Antonio, I Álvarez-Laderas, R Cardesa, F Márquez-Malaver, A Baez, M Carmona, J Falantes, M Suarez-Lledo, F Fernández-Avilés, C Martínez, M Rovira, I Espigado & Á Urbano-Ispizua (Source: Bone Marrow Transplantation)

Graft vs GIST?

Bone Marrow Transplantation — Mon, 09 Jan 2012 05:00:00 +0100

Graft vs GIST? Bone Marrow Transplantation advance online publication, January 9, 2012. doi:10.1038/bmt.2011.247 Authors: S G Holtan, S R Palmer, S H Okuno & W J Hogan (Source: Bone Marrow Transplantation)

Long-term follow-up after autologous stem cell transplantation for light- and heavy-chain deposition disease

Bone Marrow Transplantation — Mon, 09 Jan 2012 05:00:00 +0100

Authors: A Brioli, E Zamagni, S Pasquali, P Tosi, P Tacchetti, G Perrone, L Pantani, A Petrucci, B A Zannetti, M Baccarani & M Cavo (Source: Bone Marrow Transplantation)

Successful use of second cord blood transplantation to achieve long-term remission in cord blood donor cell-derived AML harboring a FLT3-ITD and an NPM1 mutation

Bone Marrow Transplantation — Mon, 09 Jan 2012 05:00:00 +0100

Authors: K Chonabayashi, T Kondo, K Yamamoto, Y Tanaka, Y Nagai, M Hishizawa & A Takaori-Kondo (Source: Bone Marrow Transplantation)

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ECIL-3 classical diagnostic procedures for the diagnosis of invasive fungal diseases in patients with leukaemia

Bone Marrow Transplantation — Mon, 09 Jan 2012 05:00:00 +0100

Authors: M C Arendrup, J Bille, E Dannaoui, M Ruhnke, C-P Heussel & C Kibbler (Source: Bone Marrow Transplantation)

Population pharmacokinetics of cyclophosphamide in patients with thalassemia major undergoing HSCT

Bone Marrow Transplantation — Mon, 09 Jan 2012 05:00:00 +0100

Authors: P Balasubramanian, S Desire, J C Panetta, K M Lakshmi, V Mathews, B George, A Viswabandya, M Chandy, R Krishnamoorthy & A Srivastava (Source: Bone Marrow Transplantation)

Deep vein thrombosis associated with a single dose of romiplostim in a high-risk patient.

American Journal of Health-System Pharmacy : AJHP — Fri, 06 Jan 2012 20:28:58 +0100

Conclusion A 63-year-old man with a history of cardiovascular disease and prior malignancy developed a DVT after receiving a single dose of romiplostim for the treatment of ITP. PMID: 22215358 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Multiple myeloma with cauda equina infiltration

Neurological Sciences — Wed, 04 Jan 2012 16:49:45 +0100

We report a case of a 51-year-old man with multiple myeloma who presented with lumbar pain and left limb paresis. Cerebrospinal fluid, brain and spinal cord resonance imaging revealed a diffuse infiltration of the cauda equina without any cranial leptomeningeal enhancement. An infiltration limited to the cauda equina is extremely rare. Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s10072-011-0920-xAuthors Thiago Cardoso Vale, Neurology Division, University Hospital, Federal University of Minas Gerais (UFMG), Avenida Professor Alfredo Balena 110/Terceiro Andar, Ala Oeste (Serviço de Neurologia), Santa Efigênia, Belo Horizonte, MG CEP 30130100, BrazilGustavo Machado Teixeira, Bone Marrow Transplantation Unit, Haematology Division, University Hospita...

Intractable Diffuse Alopecia Caused by Multifactorial Side‐Effects in Treatment of Acute Lymphocytic Leukemia: Connection to Iatrogenic Failure of Estrogen Secretion

Pediatric Dermatology — Fri, 30 Dec 2011 05:00:00 +0100

We report the case of a 22‐year‐old girl with a genetic predisposition to pattern hair loss who developed inveterate diffuse alopecia. The patient had onset of ALL at 8 years old and underwent bone marrow transplantation (BMT). Diffuse alopecia gradually advanced over her whole body. Her vellus scalp hair gradually came out, and hair loss progressed again at 8 years, after BMT. She later developed iatrogenic failure of secretion of estrogen and was treated with estrogen substitution therapy for 14 months from the age of 20. There was a small increase in the volume of hair during therapy, but alopecia returned to the former level after the therapy was suspended. Histopathologic examinations of the scalp performed during estrogen substitution therapy and 2 years after suspension ...

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Blastic plasmacytoid dendritic cell neoplasm

Australasian Journal of Dermatology — Thu, 29 Dec 2011 05:00:00 +0100

We report a case of a 79‐year old man who had 6 months of progressive, asymptomatic BPDCN manifestations limited to the skin, before developing a leukaemic phase. (Source: Australasian Journal of Dermatology)

Bone- within- Bone; interesting images of an osteopetrosis case

Journal of Pakistan Medical Students — Thu, 29 Dec 2011 05:00:00 +0100

This article has been peer reviewed. Article Submitted on: 12th October 2011 Article Accepted on: 10th November 2011 Funding sources: None Declared. Correspondence to: Saeed Shoar M.D Address:No 54, Boostan e Qods (Shilat) Dormitory, Shahed Alley, Qods Street, Keshavarz Boulevard, Tehran, Iran Email: saeedshoar@gmail.com Download PDF Clinical Image Brief History: A six-year-old boy with severe visual impairment (as a result of optic canal stenosis) was referred to the pediatric clinic of Imam Khomeini Hospital, affiliated to Tehran University of Medical Science (TUMS). Chest X-ray (PA view) revealed an abnormal increase in bone density. Other radiographic imaging helped to secure the diagnosis of “osteopetrosis”. These findings are typical bone-within-bone appe...

Leukemia and Related Disorders

Springer Medicine titles — Sun, 25 Dec 2011 03:57:57 +0100

Integrated Treatment Approachesseries:Contemporary HematologyFrom the world renowned Fred Hutchinson Cancer Research Center, this book is written for all physicians who treat patients with acute or chronic leukemias or myelodysplasia. It is designed to answer questions about treatment approaches that commonly arise in day-to-day practice. In keeping with the Center’s groundbreaking research in bone marrow transplantation, the book provides ... (Source: Springer Medicine titles)

Aprepitant for prevention of nausea and vomiting secondary to high-dose cyclophosphamide administered to patients undergoing autologous peripheral blood stem cells mobilization: a phase II trial

Supportive Care in Cancer — Thu, 22 Dec 2011 12:51:42 +0100

Abstract This is a phase II trial evaluating efficacy and safety of aprepitant (AP) in combination with 5-HT3 antagonist and adjusted dose dexamethasone in patients receiving high-dose cyclophosphamide (CY) and filgrastim for stem cell mobilization. We used Simon’s optimal two-stage design constrained to fewer than 40 patients with 10% type I error and 85% statistical power. The first stage of the study required accrual of 18 response-evaluable patients. The primary endpoint was the control of vomiting without the use of any rescue anti-emetics at 24 h after the administration of high dose CY (4 g/m2). If emesis was controlled in ≥9 patients, an additional cohort of 17 patients would be enrolled. The null hypothesis would be rejected if there were ≥20 respon...

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Bone Marrow-Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis.

Circulation Research — Thu, 22 Dec 2011 05:00:00 +0100

Conclusions:In conclusion, in bone marrow-derived cells the nuclear receptor Nur77 has an anti-inflammatory function, represses SDF-1α expression and inhibits atherosclerosis. PMID: 22194623 [PubMed - as supplied by publisher] (Source: Circulation Research)

Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models.

International Journal of Hematology — Thu, 22 Dec 2011 05:00:00 +0100

Authors: Doki N, Kitaura J, Uchida T, Inoue D, Kagiyama Y, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Kato N, Oki T, Harada Y, Nakahara F, Harada H, Kitamura T Abstract The Bcr-Abl oncogene causes human Philadelphia chromosome-positive (Ph(+)) leukemias, including B-cell acute lymphoblastic leukemia (B-ALL) and chronic myeloid leukemia (CML) with chronic phase (CML-CP) to blast crisis (CML-BC). Previous studies have demonstrated that Src family kinases are required for the induction of B-ALL, but not for CML, which is induced by Bcr-Abl in mice. In contrast, it has been reported that Fyn is up-regulated in human CML-BC compared with CML-CP, implicating Fyn in the blast crisis transition. Here, we aimed to delineate the exact role of Fyn in the induction/progression of Ph(+) leuk...

Cancer biology: Sisterhood of lymphoma

Nature — Wed, 21 Dec 2011 05:00:00 +0100

Nature 480, 7378 (2011). doi:10.1038/480417c A rare consequence of bone-marrow transplantation gave scientists the opportunity to observe the evolution of one cancer in two patients. Seven years after donating bone marrow and white blood cells called leukocytes to her sister, who was battling leukaemia, a woman was diagnosed with a (Source: Nature)

Depigmented Macules Following Autologous Bone-Marrow Transplant [Correspondence]

Archives of Dermatology — Mon, 19 Dec 2011 05:00:00 +0100

(Source: Archives of Dermatology)

An auto-SCT-based total therapy resulted in encouraging outcomes in adolescents and young adults with acute lymphoblastic leukemia: report from a single center of China

Bone Marrow Transplantation — Mon, 19 Dec 2011 05:00:00 +0100

Authors: J Huang, D-H Zou, Z-J Li, M-W Fu, Y Xu, Y-Z Zhao, J-Y Qi, S-Z Feng, B-C Liu, D Lin, Y-C Mi, M-Z Han, J-X Wang & L-G Qiu (Source: Bone Marrow Transplantation)

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Increased longevity and metabolic correction following syngeneic BMT in a murine model of mucopolysaccharidosis type I

Bone Marrow Transplantation — Mon, 19 Dec 2011 05:00:00 +0100

Authors: D A Wolf, A W Lenander, Z Nan, E A Braunlin, K M Podetz-Pedersen, C B Whitley, P Gupta, W C Low & R S McIvor (Source: Bone Marrow Transplantation)

Post-transplant endothelial disorder after hematopoietic SCT: a blinded autopsy study

Bone Marrow Transplantation — Mon, 19 Dec 2011 05:00:00 +0100

Authors: S Goyama, K Takeuchi, Y Kanda, Y Nannya, S Chiba, M Fukayama & M Kurokawa (Source: Bone Marrow Transplantation)

Allogeneic cellular and autologous stem cell therapy for sickle cell disease: ‘whom, when and how’

Bone Marrow Transplantation — Mon, 19 Dec 2011 05:00:00 +0100

Allogeneic cellular and autologous stem cell therapy for sickle cell disease: ‘whom, when and how’ Bone Marrow Transplantation advance online publication, December 19, 2011. doi:10.1038/bmt.2011.245 Authors: J Freed, J Talano, T Small, A Ricci & M S Cairo (Source: Bone Marrow Transplantation)

Mixed chimerism through donor bone marrow transplantation: a tolerogenic cell therapy for application in organ transplantation.

Current Opinion in Organ Transplantation — Mon, 19 Dec 2011 05:00:00 +0100

Mixed chimerism through donor bone marrow transplantation: a tolerogenic cell therapy for application in organ transplantation. Curr Opin Organ Transplant. 2011 Dec 19; Authors: Pilat N, Hock K, Wekerle T Abstract PURPOSE OF REVIEW: Organ transplantation is the state-of-the-art treatment for end-stage organ failure; however, long-term graft survival is still unsatisfactory. Despite improved immunosuppressive drug therapy, patients are faced with substantial side effects and the risk of chronic rejection with subsequent graft loss. The transplantation of donor bone marrow for the induction of mixed chimerism has been recognized to induce donor-specific tolerance a long time ago, but safety concerns regarding toxicities of current bone marrow transplantation (BMT) protocols i...

Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation

Fertility and Sterility — Mon, 19 Dec 2011 05:00:00 +0100

Conclusion(s): Overnight transportation of ovarian tissue appears to be possible in combination with appropriate transportation logistics. However, further investigations are needed before this procedure can be offered as a chance for women to preserve fertility independently of direct access to a tissue-processing bank. (Source: Fertility and Sterility)

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Bone marrow transplantation improves symptoms of congenital erythropoietic porphyria even when done post puberty

Indian Journal of Dermatology, Venereology and Leprology — Sat, 17 Dec 2011 05:00:00 +0100

Saurabh Singh, Neena Khanna, Lalit KumarIndian Journal of Dermatology, Venereology, and Leprology 2012 78(1):108-111 (Source: Indian Journal of Dermatology, Venereology and Leprology)

Microbial Air Monitoring as a Useful Tool When Commissioning Bone Marrow Transplant Units

Infect Control Hosp Epidemiol Latest Issue — Thu, 15 Dec 2011 23:19:44 +0100

Infection Control and Hospital Epidemiology, Volume 33, Issue 1, Page 101-102, January 2012. (Source: Infect Control Hosp Epidemiol Latest Issue)

Bone marrow transplant best for boosting blood cells

New Scientist - Health — Thu, 15 Dec 2011 11:17:22 +0100

The transplant results in fewer cases of immune attack than stem cell injections, when tissue comes from an unrelated donor (Source: New Scientist - Health)

Syndecan-1 Displays a Protective Role in Aortic Aneurysm Formation by Modulating T Cell-Mediated Responses.

Arteriosclerosis, Thrombosis and Vascular Biology — Thu, 15 Dec 2011 05:00:00 +0100

CONCLUSIONS: These investigations identify cross-talk between Sdc-1-expressing macrophages and AAA-localized CD4(+) T cells, with Sdc-1 providing an important counterbalance to T-cell-driven inflammation in the vascular wall. PMID: 22173227 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

Application of Mesenchymal Stromal Cells in Bone Marrow Transplantation for Sensitized Recipients.

Acta Haematologica — Thu, 15 Dec 2011 05:00:00 +0100

Authors: Xu LH, Fang JP, Hong DL, Wu YF Abstract Sensitized patients are at high risk for graft rejection during transplantation. It is of interest to investigate the effect of mesenchymal stromal cells (MSCs) in sensitized hematopoietic stem cell transplantation. MSCs were generated from bone marrow cells of BALB/c mice. The molecular markers of MSCs were detected by flow cytometry. MSCs labeled with green fluorescent dye were transplanted into nonsensitized and sensitized recipients, respectively. Homing of MSCs in vivo was monitored at different time points post-transplantation. Additionally, sensitized BALB/c mice under irradiation were transplanted with syngeneic MSCs and allogeneic bone marrow cells, and the rate of survival was monitored daily. The fourth passage of MSCs pre...

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A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

Journal of Clinical Investigation — Wed, 14 Dec 2011 08:26:02 +0100

Suppression of immune responses is necessary to limit damage to host tissue during inflammation, but it can be detrimental in specific immune responses, such as sepsis and antitumor immunity. Recently, immature myeloid cells have been implicated in the suppression of immune responses in mouse models of cancer, infectious disease, bone marrow transplantation, and autoimmune disease. Here, we report the identification of a subset of mature human neutrophils (CD11cbright/CD62Ldim/CD11bbright/CD16bright) as what we believe to be a unique circulating population of myeloid cells, capable of suppressing human T cell proliferation. These cells were observed in humans in vivo during acute systemic inflammation induced by endotoxin challenge or by severe injury. Local release of hydrogen peroxide fr...

Shedding Light On Lymphoma Evolution With The Help Of Two Sisters

Health News from Medical News Today — Wed, 14 Dec 2011 08:00:00 +0100

When a 41-year-old woman was diagnosed with chronic-phase chronic myeloid leukemia, she received a bone marrow transplant and subsequent leukocyte infusion from her sister. These treatments controlled her leukemia, but seven years later, both sisters developed follicular lymphoma. Although the phenomenon of a donor passing a malignancy to a recipient is well documented and considered a minimal risk to those in the transplant community, this case gave scientists the unique opportunity to understand the genetic abnormalities that led to follicular lymphoma in both cases... (Source: Health News from Medical News Today)

Impaired regulatory T cell reconstitution in patients with acute graft-versus-host disease and cytomegalovirus infection after allogeneic bone marrow transplantation.

International Journal of Hematology — Wed, 14 Dec 2011 05:00:00 +0100

Authors: Ngoma AM, Ikeda K, Hashimoto Y, Mochizuki K, Takahashi H, Sano H, Matsumoto H, Noji H, Saito S, Kikuta A, Ogawa K, Ohtsuka M, Abe M, Nollet KE, Ohto H Abstract To elucidate the correlation between regulatory T cells (Tregs) and acute graft-versus-host disease (aGVHD) or cytomegalovirus infection following allogeneic bone marrow transplantation (allo-BMT), we evaluated either CD4(+)CD25(high) or FOXP3(+) Treg-enriched cells in peripheral blood (PB) from 20 patients who received allo-BMT, and in biopsies of skin with aGVHD. Proportions of CD4(+)CD25(high)FOXP3(+) cells in total lymphocytes, but not other types of T cells, were lower in patients who eventually developed grades II-IV aGVHD (n = 13) than in others (n = 7, P < 0.001). Proportions of CD62L(+) cells in CD...

Osteoporosis After Transplantation

Current Osteoporosis Reports — Tue, 13 Dec 2011 17:04:20 +0100

Abstract Transplantation is an established therapy for end-stage diseases of kidney, lung, liver, and heart among others. Osteoporosis and fragility fractures are serious complications of organ transplantation, particularly in the first post-transplant year. Many factors contribute to the pathogenesis of osteoporosis following organ transplantation. This review addresses the mechanisms of bone loss that occurs both in the early and late post-transplant periods, including the contribution of the immunosuppressive agents as well as the specific features to bone loss after kidney, lung, liver, cardiac, and bone marrow transplantation. Prevention and treatment for osteoporosis in the transplant recipient are also discussed. Content Type Journal ArticleCategory Current Ther...

How Lymphoma Evolves - A Study Of Two Sisters

Health News from Medical News Today — Tue, 13 Dec 2011 17:00:00 +0100

A 41-year-old woman with chronic-phase chronic myeloid leukemia received a bone marrow transplant and subsequent leukocyte infusion from her sister to control her leukemia, however seven years on, both sisters developed follicular lymphoma. Cases whereby donors pass on a malignancy to their recipients are well documented and usually of minimal risk to those in the transplant community, however this case presented scientists with the opportunity to study genetic abnormalities, which led to follicular lymphoma in both cases... (Source: Health News from Medical News Today)

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Long-term follow-up of HCV-infected hematopoietic SCT patients and effects of antiviral therapy

Bone Marrow Transplantation — Mon, 12 Dec 2011 05:00:00 +0100

Authors: P Ljungman, A Locasciulli, V G de Soria, A N Békássy, L Brinch, I Espigado, A Ferrant, I M Franklin, J O'Riordan, M Rovira, P Shaw & H Einsele (Source: Bone Marrow Transplantation)

Osteonecrosis in children after allogeneic hematopoietic cell transplantation: study of prevalence, risk factors and longitudinal changes using MR imaging

Bone Marrow Transplantation — Mon, 12 Dec 2011 05:00:00 +0100

Authors: S Sharma, W-H Leung, P Deqing, J Yang, R Rochester, L Britton, M D Neel, K K Ness & S C Kaste (Source: Bone Marrow Transplantation)

Allogeneic hematopoietic SCT in patients with AML following treosulfan/fludarabine conditioning

Bone Marrow Transplantation — Mon, 12 Dec 2011 05:00:00 +0100

Allogeneic hematopoietic SCT in patients with AML following treosulfan/fludarabine conditioning Bone Marrow Transplantation advance online publication, December 12, 2011. doi:10.1038/bmt.2011.242 Authors: J Casper, J Holowiecki, R Trenschel, H Wandt, K Schaefer-Eckart, T Ruutu, L Volin, H Einsele, G Stuhler, L Uharek, I Blau, M Bornhaeuser, A R Zander, K Larsson, M Markiewicz, S Giebel, T Kruzel, H A Mylius, J Baumgart, U Pichlmeier, M Freund & D W Beelen (Source: Bone Marrow Transplantation)

Secondary MGUS after autologous hematopoietic progenitor cell transplantation in plasma cell myeloma: a matter of undetermined significance

Bone Marrow Transplantation — Mon, 12 Dec 2011 05:00:00 +0100

Authors: G V Manson, E Campagnaro, A Balog, D Kaplan, S R Sommers, P Fu, S V Rajkumar & H M Lazarus (Source: Bone Marrow Transplantation)

Comparison of stem cell sources in the severity of dry eye after allogeneic haematopoietic stem cell transplantation

British Journal of Ophthalmology — Mon, 12 Dec 2011 05:00:00 +0100

Conclusion The data in this study suggested that the severity and onset time of DE were affected by the stem cell source. Close attention must be paid to the development of late-onset severe DE in PBSCT recipients. (Source: British Journal of Ophthalmology)

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Clostridium difficile infection in HIV-seropositive individuals and transplant recipients

Journal of Infection — Mon, 12 Dec 2011 05:00:00 +0100

Summary: Immunocompromise is a commonly cited risk factor for Clostridium difficile infection (CDI). We reviewed the experimental and epidemiological literature on CDI in three immunocompromised groups, HIV-seropositive individuals, haematopoietic stem cell or bone marrow transplant recipients and solid organ transplant recipients. All three groups have varying degrees of impairment of humoral immunity, a major factor influencing the outcome of CDI. Soluble HIV proteins such as nef and immunosuppressive agents such as cyclosporin, azathioprine and mycophenalate mofetil modify signalling from the key cellular pathways triggered by C. difficile toxin A, although there is a paucity of data on how these factors may interact with pathways activated by toxin B. Despite this, there has been littl...

How haematological cancer nurses experience the threat of patients’ mortality

Journal of Advanced Nursing — Sun, 11 Dec 2011 05:00:00 +0100

Conclusion. Results suggest enhancing nurses’ capacity to negotiate more effectively the contradictory clinical tasks of fighting disease and preparing patients for the end of life. In this regard, nurses may minimize patients’ distress by providing opportunities for them to share their fears and have them validated. (Source: Journal of Advanced Nursing)

Posterior reversible encephalopathy syndrome in an adult patient with acute lymphoblastic leukemia after remission induction chemotherapy.

International Journal of Hematology — Fri, 09 Dec 2011 05:00:00 +0100

We present a case of PRES in an adult patient with acute lymphoblastic leukemia (ALL) after remission induction chemotherapy. A 28-year-old woman with ALL was administered remission induction chemotherapy consisting of cyclophosphamide, daunorubicin, vincristine, prednisone, and L: -asparaginase. After initiation of chemotherapy, the patient developed paralytic ileus and hypertension, and on day 30, she suddenly developed generalized convulsions, loss of visual acuity, and muscle weakness in the legs. Magnetic resonance imaging findings and her signs and symptoms were typical of PRES. The symptoms gradually improved following treatment with an anticonvulsant and an antihypertensive agent, and the patient underwent allogeneic bone marrow transplantation. She has completely recovered from PR...

Moffitt researchers will be strong participants in American Society of Hematology meeting

EurekAlert! - Medicine and Health — Mon, 05 Dec 2011 05:00:00 +0100

(H. Lee Moffitt Cancer Center & Research Institute) When the American Society of Hematology convenes its 53rd Annual Meeting and Exposition on Dec. 10-13 in San Diego, Calif., researchers from Moffitt Cancer Center will break a new record for Moffitt participants with one plenary presentation, 16 oral presentations and more than 50 poster presentations on new research results in a variety of meeting programs that focus on blood cancer basic science and clinical applications, including bone marrow transplantation and clinical trials results. (Source: EurekAlert! - Medicine and Health)

Optimizing a photoallodepletion protocol for adoptive immunotherapy after haploidentical SCT

Bone Marrow Transplantation — Mon, 05 Dec 2011 05:00:00 +0100

Authors: K Perruccio, F Topini, A Tosti, A Carotti, E Burchielli, L Ruggeri, A Mancusi, E Urbani, F Aversa, M F Martelli & A Velardi (Source: Bone Marrow Transplantation)

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Patient information in stem cell transplantation from the perspective of health care professionals: A survey from the Nurses Group of the European Group for Blood and Marrow Transplantation

Bone Marrow Transplantation — Mon, 05 Dec 2011 05:00:00 +0100

Authors: M Kirsch, P Crombez, S Calza, C Eeltink & E Johansson (Source: Bone Marrow Transplantation)

Is it time to revisit our current hematopoietic progenitor cell quantification methods in the clinic?

Bone Marrow Transplantation — Mon, 05 Dec 2011 05:00:00 +0100

Is it time to revisit our current hematopoietic progenitor cell quantification methods in the clinic? Bone Marrow Transplantation advance online publication, December 5, 2011. doi:10.1038/bmt.2011.240 Authors: M Beksac & F Preffer (Source: Bone Marrow Transplantation)

Differential impact of inhibitory and activating Killer Ig-Like Receptors (KIR) on high-risk patients with myeloid and lymphoid malignancies undergoing reduced intensity transplantation from haploidentical related donors

Bone Marrow Transplantation — Mon, 05 Dec 2011 05:00:00 +0100

Authors: D-F Chen, V K Prasad, G Broadwater, N L Reinsmoen, A DeOliveira, A Clark, K M Sullivan, J P Chute, M E Horwitz, C Gasparetto, G D Long, Y Yang, N J Chao & D A Rizzieri (Source: Bone Marrow Transplantation)

Importance of day 21 BM chimerism in sustained neutrophil engraftment following double-unit cord blood transplantation

Bone Marrow Transplantation — Mon, 05 Dec 2011 05:00:00 +0100

Authors: S Avery, M H Voss, A M Gonzales, M Lubin, H Castro-Malaspina, S Giralt, N A Kernan, A Scaradavou, C V Hedvat, C E Stevens & J N Barker (Source: Bone Marrow Transplantation)

Some Stem Cell Donors Can Be Paid, Court Rules

NYT — Fri, 02 Dec 2011 20:50:07 +0100

An appeals court says a law prohibiting payment for donated organs did not apply to stem cells extracted from circulating blood. (Source: NYT)

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Anti-thrombin-III reduction and posterior reversible encephalopathy syndrome (PRES) in acute lymphoblastic leukaemia (ALL). New insight into PRES pathophysiology

Annals of Hematology — Fri, 02 Dec 2011 06:48:14 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1376-zAuthors Andrea Piccin, Department of Haematology and Bone Marrow Transplant Unit, San Maurizio Regional Hospital, Bolzano, South Tyrol, ItalyRoberto Currò Dossi, Stroke Unit, Department of Internal Medicine, San Maurizio Regional Hospital, Bolzano, South Tyrol, ItalyVincenzo Cassibba, Department of Haematology and Bone Marrow Transplant Unit, San Maurizio Regional Hospital, Bolzano, South Tyrol, ItalySigmund Stupnner, Department of Radiology, San Maurizio Regional Hospital, Bolzano, South Tyrol, ItalyGiampietro Bonatti, Department of Radiology, San Maurizio Regional Hospital, Bolzano, South Tyrol, ItalySergio Cortelazzo, Department of Haematology and Bone Marrow Transplant Unit, San Maurizio...

Some Stem Cell Donors Can Be Paid, Court Rules

NYT Health — Fri, 02 Dec 2011 02:22:52 +0100

An appeals court says a law prohibiting payment for donated organs did not apply to stem cells extracted from circulating blood. (Source: NYT Health)

Morphological characterization of the progenitor blood cells in canine and feline umbilical cord

Microscopy Research and Technique — Thu, 01 Dec 2011 05:00:00 +0100

This study is aimed at morphological characterization of progenitor cells derived from UCB highlighting relevant differences with peripheral blood of adult in dog and cats. Therefore, blood was collected from 18 dogs and 5 cats' umbilical cords from fetus in various developmental stages. The mononuclear cells were separated using the gradient of density Histopaque‐1077. Characterization of CD34+ cells was performed by flow cytometric analysis and transmission electron microscopy. Granulocytes (ancestry of the basophiles, eosinophiles, and neutrophiles) and agranulocytes (represented by immature lymphocytes) were identified. We showed for the first time the ultrastructural features of cat UCB cells. Microsc. Res. Tech. , 2011. © 2011 Wiley Periodicals, Inc. (Source: Microscopy Research a...

Leukemia relapse after allogeneic bone marrow transplantation: how does chronic graft-versus-host disease influence the pattern and onset of relapse?

Thu, 01 Dec 2011 05:00:00 +0100

We describe a pattern of relapse in 601 patients who received an allogeneic hematopoietic stem cell transplant at our institution for acute or chronic leukemia and myelodysplasia over a period of 18 years. We show a correlation between chronic graft-versus-host disease and extramedullary relapse, suggesting that the expected graft versus leukemia effect in patients with chronic graft-versushost disease may preferentially maintain marrow remission without preventing relapse in extramedullary sites. PMID: 22142055 [PubMed - in process] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)

Rapidly progressive fatal hemorrhagic pneumonia caused by Stenotrophomonas maltophilia in hematologic malignancy

Transplant Infectious Disease — Thu, 01 Dec 2011 05:00:00 +0100

ConclusionsHemorrhagic S. maltophilia pneumonia rapidly progresses and is fatal in patients with hematologic malignancy. Attention should be particularly paid to the neutropenic phase early after HSCT or prolonged neutropenia due to engraftment failure. A prompt trimethoprim‐sulfamethoxazole‐based multidrug combination regimen should be considered to rescue suspected cases of S. maltophilia pneumonia in these severely immunosuppressed patients. (Source: Transplant Infectious Disease)

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Chimerism detection by short tandem repeat analysis when donor and recipient genotypes are not known.

International Journal of Clinical Chemistry — Tue, 29 Nov 2011 05:00:00 +0100

CONCLUSION: This minimum STR panel may be an efficient way to detect and quantitate donor-recipient chimerism after transplantation. PMID: 22155342 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)

Fertility preservation in young patients before allogeneic haematopoietic SCT

Bone Marrow Transplantation — Mon, 28 Nov 2011 05:00:00 +0100

Authors: L Bastings, J R Westphal, C C M Beerendonk, D D M Braat & R Peek (Source: Bone Marrow Transplantation)

Escalated lymphodepletion followed by donor lymphocyte infusion can induce a graft-versus-host response without overwhelming toxicity

Bone Marrow Transplantation — Mon, 28 Nov 2011 05:00:00 +0100

Authors: T Guillaume, B Gaugler, P Chevallier, J Delaunay, S Ayari, A Clavert, F Rialland, S Le Gouill, N Blin, T Gastinne, B Mahé, V Dubruille, P Moreau & M Mohty (Source: Bone Marrow Transplantation)

Significant interaction of tacrolimus with ritonavir during allogeneic hematopoietic SCT in an HIV-infected patient

Bone Marrow Transplantation — Mon, 28 Nov 2011 05:00:00 +0100

Authors: M Miceli, S Cronin, L Ayash, G Alangaden & P H Chandrasekar (Source: Bone Marrow Transplantation)

Alteration of Dickkopf-1 and receptor activator of nuclear factor-κB ligand during PBSC mobilization in healthy donors by G-CSF

Bone Marrow Transplantation — Mon, 28 Nov 2011 05:00:00 +0100

Alteration of Dickkopf-1 and receptor activator of nuclear factor-κB ligand during PBSC mobilization in healthy donors by G-CSF Bone Marrow Transplantation advance online publication, November 28, 2011. doi:10.1038/bmt.2011.233 Authors: M Tanaka, T Yujiri, Y Tanaka, N Mitani, A Tanimura & Y Tanizawa (Source: Bone Marrow Transplantation)

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A natural compound induced cardiogenic differentiation of endogenous MSCs for repair of infarcted heart.

Differentiation — Sun, 27 Nov 2011 15:55:53 +0100

In this study, replacement of the dangerous intra-myocardial injection with a safe method and whether the endogenous MSCs contribute to the cardiogenin-mediated myocardial regeneration were investigated. Bone marrow transplantation with labeled MSCs was performed in rats, which were subsequently subject to a permanent ligation of left anterior descending coronary artery one week after the transplantation. The rats were then treated with the cardiogenin through oral administration for 2 weeks. We not only demonstrated the substantial therapeutic effects of cardiogenin on myocardial infarction through an oral administration, but also provided direct evidences that the bone marrow derived endogenous MSCs are the major cellular source of the regenerating myocardium. Preliminary mechanistic stu...

Digestive complaints in patients with hematologic malignancies undergoing bone marrow transplantation.

Onkologie — Fri, 25 Nov 2011 16:00:02 +0100

Authors: Skop-Lewandowska A, Kolarzyk E, Skotnicki AB Abstract The aim of this study was to assess the severity and frequency of complaints affecting the digestive system in 57 patients with hematological malignancies, who underwent allogeneic (Group I, n = 22) and autologous (Group II, n = 35) hematopoietic stem cell transplantation. Chemotherapy-related toxicities affecting the digestive system (mucositis, nausea/vomiting, diarrhea) were assessed according to the WHO scale for organ toxicity. Selection of the feeding route (oral or parenteral) depended on the tolerance to oral nutrition. Parenteral nutrition (PN) was introduced when oral intake represented ≤ 50% of the total energy requirement over 2 days. PN was started in the third 24-h period. 63.6% of patients undergoing al...

[Comment] Rabbit ATG for aplastic anaemia treatment: a backward step?

LANCET — Fri, 25 Nov 2011 12:00:53 +0100

Advances in medical care and research invariably result in improved outcomes for patients over time. Aplastic anaemia is a rare but serious form of bone-marrow failure that results in severe pancytopenia, a high risk of life-threatening infection, and haemorrhage. Over the past five decades, survival of patients has improved from around 25% to 60–80%, as allogeneic bone-marrow transplantation or immunosuppressive therapy have become available. However, a recent change in the availability of immunosuppressive therapy drugs has had a negative impact on patients' outcome. (Source: LANCET)

A novel application of statistical process control charts - monitoring air quality in a paediatric haematology/oncology unit: Category: Lesson in Microbiology & Infection Control

Journal of Infection — Fri, 25 Nov 2011 11:05:46 +0100

This study sought to determine whether the same principles of process management were useful in environmental air monitoring of high risk healthcare units. Results of air sampling at several sites within the paediatric haematology/oncology/BMT unit (in addition to external sites within the hospital grounds) collected over a 2 year period were used to produce SPC charts. (Source: Journal of Infection)

Hematopoietic stem cell transplantation in T-prolymphocytic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation and the Royal Marsden Consortium

Leukemia — Fri, 25 Nov 2011 05:00:00 +0100

Authors: W Wiktor-Jedrzejczak, C Dearden, L de Wreede, A van Biezen, L Brinch, V Leblond, M Brune, L Volin, M Kazmi, A Nagler, J Schetelig, T de Witte & P Dreger (Source: Leukemia)

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Live birth with vitrified-warmed oocytes of a chronic myeloid leukemia patient nine years after allogenic bone marrow transplantation

Journal of Assisted Reproduction and Genetics — Thu, 24 Nov 2011 17:49:49 +0100

Content Type Journal ArticleCategory Fertility PreservationPages 1-4DOI 10.1007/s10815-011-9681-yAuthors Mi Kyoung Kim, Department of Obsterics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, 606-13 Yeoksam-dong, Gangnam-gu, Seoul, 135-081 South KoreaDong Ryul Lee, Department of Biomedical Science, Fertility Center of CHA Gangnam Medical Center, CHA University, 606-13 Yeoksam-dong, Gangnam-gu, Seoul, 135-081 South KoreaJi Eun Han, Department of Obsterics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, 606-13 Yeoksam-dong, Gangnam-gu, Seoul, 135-081 South KoreaYou Shin Kim, Department of Obsterics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, 606-13 Yeoksam-dong, Gangnam-gu, Seoul, 135-081 ...

In Reply to ‘Development of Thrombotic Microangiopathy in a Patient With Granulomatosis With Polyangiitis’

American Journal of Kidney Diseases — Wed, 23 Nov 2011 01:11:39 +0100

We thank Park et al for their letter regarding the potential role that increased interleukin 12 (IL-12) levels secondary to mycophenolate mofetil (MMF) treatment withdrawal may have had in the development of thrombotic microangiopathy in our patient. As they mention, Lamprecht et al showed a decrease in elevated IL-12 levels in 6 patients with granulomatosis with polyangiitis (Wegener) treated with corticosteroids and cyclophosphamide. Also, Mehling et al showed IL-12 suppression in response to MMF in a murine model although the possibility that MMF treatment withdrawal may increase IL-12 levels was not studied. Our patient did not have evidence of active granulomatosis with polyangiitis, and IL-12 measurement would not have been feasible because this test was not available clinically. In ...

Intensification of GVHD prophylaxis with low-dose ATG-F before allogeneic PBSC transplantation from HLA-identical siblings in adult patients with hematological malignancies: results from a retrospective analysis

Bone Marrow Transplantation — Mon, 21 Nov 2011 05:00:00 +0100

Authors: F Bonifazi, G Bandini, M Arpinati, G Tolomelli, M Stanzani, M R Motta, S Rizzi, V Giudice, E Dan, E Massari, P Tazzari, A Bontadini, P Pagliaro & M Baccarani (Source: Bone Marrow Transplantation)

Validation of pretransplantation assessment of mortality risk score in the outcome of hematopoietic SCT in non-Caucasians

Bone Marrow Transplantation — Mon, 21 Nov 2011 05:00:00 +0100

Authors: Y Mori, T Teshima, K Kamezaki, K Kato, K Takenaka, H Iwasaki, T Miyamoto, K Nagafuji, T Eto & K Akashi (Source: Bone Marrow Transplantation)

Amelioration of acute graft-versus-host disease by adoptive transfer of ex vivo expanded human cord blood CD4+CD25+ forkhead box protein 3+ regulatory T cells is associated with the polarization of Treg/Th17 balance in a mouse model.

Transfusion — Mon, 21 Nov 2011 05:00:00 +0100

CONCLUSION: Ex vivo expanded human CB-Tregs significantly prevented allogeneic aGVHD in vivo by modulating various cytokine secretion and polarizing the Treg/Th17 balance toward Treg, which suggests the potential use of expanded CB-Tregs as a therapeutic approach for GVHD. PMID: 22098312 [PubMed - as supplied by publisher] (Source: Transfusion)

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Sailor, 26, with cancer so rare it doesn't have a name completes voyage around Britain for bone marrow donors

the Mail online | Health — Mon, 21 Nov 2011 02:50:56 +0100

Oliver Rofix, of Ipswich, Suffolk, was first diagnosed with the strain of leukaemia in 2005 but had a successful bone marrow transplant and beat the disease after four years of treatment. (Source: the Mail online | Health)

Rik's desperate race to find a stem cell donor

Telegraph Health — Fri, 18 Nov 2011 17:08:10 +0100

Rik Basra needs a bone marrow transplant, can you help, asks Abigail Butcher. (Source: Telegraph Health)

Prevention of recurrent herpes labialis outbreaks through low-intensity laser therapy: a clinical protocol with 3-year follow-up

Lasers in Medical Science — Tue, 15 Nov 2011 16:48:47 +0100

Content Type Journal ArticleCategory Brief ReportPages 1-7DOI 10.1007/s10103-011-1019-6Authors Carlos de Paula Eduardo, Special Laboratory of Lasers in Dentistry – LELO, Department of Restorative Dentistry, Faculdade de Odontologia da Universidade de São Paulo, São Paulo, BrazilLetícia Mello Bezinelli, Hematology and Bone Marrow Transplantation, Hospital Israelita Albert Einstein – HIAE, São Paulo, BrazilFernanda de Paula Eduardo, Hematology and Bone Marrow Transplantation, Hospital Israelita Albert Einstein – HIAE, São Paulo, BrazilRoberta Marques da Graça Lopes, Hematology and Bone Marrow Transplantation, Hospital Israelita Albert Einstein – HIAE, São Paulo, BrazilKaren Müller Ramalho, Special Laboratory of Lasers in Dentistry – LELO, Department of Restorative Denti...

Dipeptidyl peptidase IV (DPPIV/CD26) inhibition does not improve engraftment of unfractionated syngeneic or allogeneic bone marrow after nonmyeloablative conditioning

Experimental Hematology — Tue, 15 Nov 2011 05:00:00 +0100

In order to develop minimally toxic bone marrow transplantation (BMT) protocols suitable for use in a wider range of indications, it is important to identify ways to enhance BM engraftment at a given level of recipient conditioning. CXCL12/stromal cell-derived factor-1α plays a crucial physiological role in homing of hematopoietic stem cells to BM. It is regulated by the ectopeptidase dipeptidyl peptidase IV (DPPIV; DPP4) known as CD26, which cleaves dipeptides from the N-terminus of polypeptide chains. Blocking DPPIV enzymatic activity had a beneficial effect on hematopoietic stem cell engraftment in various but very specific experimental settings. Here we investigated whether inhibition of DPPIV enzymatic activity through Diprotin A or sitagliptin (Januvia) improves BM engraftment in no...

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The New Petri Dish - Plasma In A Bag

Health News from Medical News Today — Mon, 14 Nov 2011 08:00:00 +0100

Using plasmas, sealed plastic bags can be modified at atmospheric pressure so that human cells can adhere to and reproduce on their walls. Cell culture bags of this kind are an important aid for research and clinical purposes and may eventually replace the Petri dishes used today. Physicians are increasingly using live cells in their treatments: in blood transfusions and bone marrow transplants, as well as in stem cell therapies and following severe burns... (Source: Health News from Medical News Today)

Durable complete remission after single agent decitabine in AML relapsing in extramedullary sites after allo-SCT

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: S N Singh, Q Cao, I Gojo, A P Rapoport & G Akpek (Source: Bone Marrow Transplantation)

European data on stem cell mobilization with plerixafor in non-Hodgkin's lymphoma, Hodgkin's lymphoma and multiple myeloma patients. A subgroup analysis of the European Consortium of stem cell mobilization

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: K Hübel, M M Fresen, J F Apperley, G W Basak, K W Douglas, I H Gabriel, C Geraldes, O Jaksic, Z Koristek, N Kröger, F Lanza, R M Lemoli, G Mikala, D Selleslag, N Worel, M Mohty & R F Duarte (Source: Bone Marrow Transplantation)

Preemptive dosing of plerixafor given to poor stem cell mobilizers on day 5 of G-CSF administration

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: M E Horwitz, J P Chute, C Gasparetto, G D Long, C McDonald, A Morris, D A Rizzieri, K M Sullivan & N J Chao (Source: Bone Marrow Transplantation)

Potential prolongation of PFS in mantle cell lymphoma after R-HyperCVAD: auto-SCT consolidation or rituximab maintenance

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: T Ahmadi, J McQuade, D Porter, N Frey, A W Loren, S C Goldstein, J Svoboda, E Stadtmauer, S J Schuster & S D Nasta (Source: Bone Marrow Transplantation)

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HLA-matched sibling stem cell transplantation in children with β-thalassemia with anti-thymocyte globulin as part of the preparative regimen: the Greek experience

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

HLA-matched sibling stem cell transplantation in children with β-thalassemia with anti-thymocyte globulin as part of the preparative regimen: the Greek experience Bone Marrow Transplantation advance online publication, November 14, 2011. doi:10.1038/bmt.2011.219 Authors: E Goussetis, I Peristeri, V Kitra, G Vessalas, A Paisiou, M Theodosaki, E Petrakou, M N Dimopoulou & S Graphakos (Source: Bone Marrow Transplantation)

Allo-SCT in a patient with CRMCC with aplastic anemia using a reduced intensity conditioning regimen

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: D Asai, S Osone, T Imamura, H Sakaguchi, N Nishio, H Kuroda, S Kojima & H Hosoi (Source: Bone Marrow Transplantation)

Tolerance to liver allograft after allogeneic hematopoietic cell transplantation for severe aplastic anemia from the same HLA-matched sibling donor

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: H Sun, G Therapondos, J Lipton & V Gupta (Source: Bone Marrow Transplantation)

Clofarabine and CY do not yield reliable engraftment of hematopoietic stem cells

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: J Karch, J Zhu, W C Ehmann & D Claxton (Source: Bone Marrow Transplantation)

Plerixafor in AL amyloidosis: improved graft composition and faster lymphocyte recovery after auto-SCT in patient with end-stage renal-disease

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: D Dunn, P Vikas, M Jagasia & B N Savani (Source: Bone Marrow Transplantation)

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Successful treatment with plasma exchange for disseminated cidofovir-resistant adenovirus disease in a pediatric SCT recipient

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: T Nishikawa, K Nakashima, R Fukano, J Okamura & J Inagaki (Source: Bone Marrow Transplantation)

Clinical effectiveness of hyperbaric oxygen therapy for BK-virus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation

Bone Marrow Transplantation — Mon, 14 Nov 2011 05:00:00 +0100

Authors: J Savva-Bordalo, C Pinho Vaz, M Sousa, R Branca, F Campilho, R Resende, I Baldaque, O Camacho & A Campos (Source: Bone Marrow Transplantation)

Pulmonary embolisation of bone fragments from penetrating cranial gunshot wounds. - Cecchi R, Cipolloni L, Sestili C, Aromatario M, Ciallella C.

SafetyLit: All (Unduplicated) — Sun, 13 Nov 2011 23:51:22 +0100

Bone embolism is a very rare event that usually occurs in trauma-induced septic bone lesions, after bone surgery or after bone marrow transplantation, and normally remains silent. To our knowledge, there are no previous reports of bone embolism after a gun... (Source: SafetyLit: All (Unduplicated))

Early engraftment of G-CSF-primed allogeneic bone marrow transplantation in pediatric patients regardless of donor–recipient weight differences

Annals of Hematology — Fri, 11 Nov 2011 06:54:34 +0100

Abstract Harvesting sufficient progenitor cells from bone marrow (BM) for pediatric patients is a challenging process, especially from smaller donors. Growth factor administration to donors prior to harvest results in an enrichment of the graft and leads to early engraftment. A total of 41 patients received a human leukocyte antigen-identical sibling transplantation using granulocyte colony-stimulating factor (G-CSF)-primed BM. All donors received G-CSF 10 μg/kg/day for 2 days prior to harvest. The median weight difference between donor and recipient was 3.9 kg (range, −29.8 to 32 kg), and the median number of CD34+ cells harvested was 4.16 × 106/kg (range, 1.17–31.9 × 106/kg). The median time to neutrophil engraftment was 12 days (ran...

Hurler disease (Mucopolysaccharidosis type IH): clinical features and consanguinity in Tunisian population

Diagnostic Pathology — Thu, 10 Nov 2011 05:00:00 +0100

Conclusion: The high frequency of p.P533R mutation could be explained by the high degree of inbreeding. This is due to the richness of the genetic background of the studied population.A multidisciplinary approach is essential to develop adequate preventive program adapted to the social, cultural, and economic context. (Source: Diagnostic Pathology)

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Donor immunization with WT1 peptide augments antileukemic activity after MHC-matched bone marrow transplantation

Blood — Thu, 10 Nov 2011 05:00:00 +0100

The curative potential of MHC-matched allogeneic bone marrow transplantation (BMT) is in part because of immunologic graft-versus-tumor (GvT) reactions mediated by donor T cells that recognize host minor histocompatibility antigens. Immunization with leukemia-associated antigens, such as Wilms Tumor 1 (WT1) peptides, induces a T-cell population that is tumor antigen specific. We determined whether allogeneic BMT combined with immunotherapy using WT1 peptide vaccination of donors induced more potent antitumor activity than either therapy alone. WT1 peptide vaccinations of healthy donor mice induced CD8+ T cells that were specifically reactive to WT1-expressing FBL3 leukemia cells. We found that peptide immunization was effective as a prophylactic vaccination before tumor challenge, yet was ...

Pulmonary embolisation of bone fragments from penetrating cranial gunshot wounds

International Journal of Legal Medicine — Wed, 09 Nov 2011 17:54:10 +0100

We describe a case of pulmonary embolism associated with bone fragments after a gunshot to the head in which bone fragments surrounded by leukocytes, interstitial and intra-alveolar oedema and haemorrhage around the embolised vessels, leukostasis and fat and bone marrow embolism suggest that the survival time from the gunshot was sufficiently long to allow changes in lung microcirculation and lung tissue. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s00414-011-0643-9Authors R. Cecchi, Department of anatomical, histological, medico-legal and locomotor apparatus sciences, Forensic Medicine section, Sapienza University of Rome, Rome, ItalyL. Cipolloni, Department of anatomical, histological, medico-legal and locomotor apparatus sciences, Forensic Medicine sec...

Racial disparities in hematopoietic cell transplantation in the United States

Bone Marrow Transplantation — Mon, 07 Nov 2011 05:00:00 +0100

Authors: N S Majhail, S Nayyar, M E Burton Santibañez, E A Murphy & E M Denzen (Source: Bone Marrow Transplantation)

Glans penis involvement: an under-recognized manifestation of chronic GVHD

Bone Marrow Transplantation — Mon, 07 Nov 2011 05:00:00 +0100

Authors: J Yared, I Gojo & G Akpek (Source: Bone Marrow Transplantation)

Autologous hematopoietic cell transplantation following high-dose immunosuppressive therapy for advanced multiple sclerosis: long-term results

Bone Marrow Transplantation — Mon, 07 Nov 2011 05:00:00 +0100

Authors: J D Bowen, G H Kraft, A Wundes, Q Guan, K R Maravilla, T A Gooley, P A McSweeney, S Z Pavletic, H Openshaw, R Storb, M Wener, B A McLaughlin, G R Henstorf & R A Nash (Source: Bone Marrow Transplantation)

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Prevention of relapse using granulocyte CSF-primed PBPCs following HLA-mismatched/haploidentical, T-cell-replete hematopoietic SCT in patients with advanced-stage acute leukemia: a retrospective risk-factor analysis

Bone Marrow Transplantation — Mon, 07 Nov 2011 05:00:00 +0100

Prevention of relapse using granulocyte CSF-primed PBPCs following HLA-mismatched/haploidentical, T-cell-replete hematopoietic SCT in patients with advanced-stage acute leukemia: a retrospective risk-factor analysis Bone Marrow Transplantation advance online publication, November 7, 2011. doi:10.1038/bmt.2011.213 Authors: Y Wang, D-H Liu, L-P Xu, K-Y Liu, H Chen, X-H Zhang, Y-H Chen, W Han, F-R Wang, J-Z Wang, C-H Yan & X-J Huang (Source: Bone Marrow Transplantation)

Survival time of cardiac allografts prolonged by isogeneic BMT in mice

Bone Marrow Transplantation — Mon, 07 Nov 2011 05:00:00 +0100

Authors: Z Chen, H Jiang, R Chen, S Feng, J Jin, Y Bi, H Yang & J Chen (Source: Bone Marrow Transplantation)

LPS-Induced Murine Systemic Inflammation Is Driven by Parenchymal Cell Activation and Exclusively Predicted by Early MCP-1 Plasma Levels.

The American Journal of Pathology — Sat, 05 Nov 2011 04:00:00 +0100

Authors: Juskewitch JE, Knudsen BE, Platt JL, Nath KA, Knutson KL, Brunn GJ, Grande JP Abstract Systemic inflammation remains a major cause of morbidity and mortality in the United States, across many disease processes. One classic murine model to study this syndrome is lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4)-dependent systemic inflammation. Although most studies have focused on inflammatory cell TLR4 responses, parenchymal cells also express TLR4. Our objective was to define the in vivo role of parenchymal- versus marrow-derived cell activation via TLR4 during LPS-induced inflammation. Mice bearing TLR4 on parenchymal cells only, marrow-derived cells only, both, or neither were generated using bone marrow transplantation. Mortality occurred only in mice that h...

The effects of leflunomide on CD4+CD25+Foxp3+ T regulatory cells in mice receiving allogeneic bone marrow transplantation

Inflammation Research — Fri, 04 Nov 2011 16:54:02 +0100

Conclusions LEF decreases peripheral CD4+CD25+ Treg cells in un-immunizing and immunizing recipients, indicating that LEF might not be an ideal candidate for the treatment of autoimmune diseases or graft rejection with respect to induction of immune tolerance. Content Type Journal ArticleCategory Original Research PaperPages 1-8DOI 10.1007/s00011-011-0388-4Authors Di Jin, Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beichen Xi Road 1-5, Beijing, 100101 ChinaKaizhong Duan, Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beichen Xi Road 1-5, Beijing,...

Benefit from autologous stem cell transplantation in primary refractory myeloma? Different outcomes in progressive versus stable disease.

Haematologica — Fri, 04 Nov 2011 04:00:00 +0100

Conclusions. Our results show that patients with progressive refractory myeloma do not benefit from autologous transplant, while patients with stable disease have an outcome comparable to those with chemosensitive disease. (ClinicalTrials.gov:NCT00560053). PMID: 22058223 [PubMed - as supplied by publisher] (Source: Haematologica)

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Comparison of stem cell sources in the severity of dry eye after allogeneic haematopoietic stem cell transplantation.

The British Journal of Ophthalmology — Thu, 03 Nov 2011 04:00:00 +0100

ConclusionThe data in this study suggested that the severity and onset time of DE were affected by the stem cell source. Close attention must be paid to the development of late-onset severe DE in PBSCT recipients. PMID: 22053104 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)

Blood, Bone Cancer - Low-Toxicity Conditioning Regimen Before Cell Transplantation Helps

Health News from Medical News Today — Wed, 02 Nov 2011 17:00:00 +0100

According to an investigation in the November 2 issue of JAMA, older individuals who received a conditioning regimen that consisted of minimal-intensity radiation therapy for advanced hematologic malignancies, such as lymphoma and leukemia, before receiving allogeneic (genetically different) hematopoietic cell transplantation (HCT; recipe of stem cells or bone marrow transplant) had progression-free and survival outcomes indicating that this treatment method might be a suitable option for older individuals with these cancers... (Source: Health News from Medical News Today)

Use of linezolid in neonatal and pediatric inpatient facilities—results of a retrospective multicenter survey

European Journal of Clinical Microbiology and Infectious Diseases — Wed, 02 Nov 2011 16:58:01 +0100

Abstract The purpose of this investigation was to describe the use of linezolid in pediatric inpatient facilities. A retrospective multicenter survey including data from nine participating tertiary care pediatric inpatient facilities in Germany and Austria was undertaken. Data on 126 off-label linezolid treatment courses administered to 108 patients were documented. The survey comprises linezolid treatment in a broad spectrum of clinical indications to children of all age groups; the median age was 6.8 years (interquartile range 0.6–15.5 years; range 0.1–21.2 years; ten patients were older than 18 years of age but were treated in pediatric inpatient units). Of the 126 treatment courses, 27 (21%) were administered to preterm infants, 64 (51%) to pedi...

The role of neuromuscular blocking drugs in early severe acute respiratory distress syndrome.

Canadian Journal of Anaesthesia — Tue, 01 Nov 2011 04:00:00 +0100

CONCLUSIONS: Treatment in early severe ARDS with the NMBA, cisatracurium, for 48 hr was associated with lower adjusted 90-day mortality. It was also associated with decreased morbidity, which included increased ventilator-free days, increased ICU-free days, and increased organ failure-free days. These benefits occurred without increasing the incidence of ICU-acquired weakness. PMID: 22042702 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)

Engineering of Bone Marrow Cells With Fas-ligand Protein–Enhances Donor-specific Tolerance to Solid Organs

Transplantation Proceedings — Tue, 01 Nov 2011 04:00:00 +0100

This study evaluates the possibility of substitution of immune cells for bone marrow cells (BMC) to induce FasL-mediated tolerance to solid organ grafts. Expression of FasL protein on BMC increased the survival of simultaneously grafted vascularized heterotopic cardiac grafts to 90%, as compared to 30% in recipients of naïve BMC. Similar results were obtained for skin allografts implanted into radiation chimeras at 1 week after bone marrow transplantation. Further reduction of preparative conditioning to busulfan resulted in acceptance of donor skin implanted at 2 weeks after transplantation of naïve and FasL-coated BMC, whereas third-party grafts were acutely rejected. The levels of donor chimerism were in the range of 0.7% to 12% at the time of skin grafting, with higher levels in reci...

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Vascularized Bone Marrow Transplantation Model in Rats as an Alternative to Conventional Cellular Bone Marrow Transplantation: Preliminary Results

Transplantation Proceedings — Tue, 01 Nov 2011 04:00:00 +0100

Abstract: The aim of the study was to follow the development of microchimerism after allogeneic vascularized bone marrow transplantation (VBMT) versus conventional bone marrow transplantation (BMT). In one group, a VBMT model consisted of donor Brown Norway rat hind limb heterotopic transplanted on recipient Lewis rats. An intravenous infusion of donor bone marrow cells in suspension equivalent to that grafted in the vascularized femur limb was administered intravenously to recipient rats in the second group. Cellular microchimerism was investigated in recipients of VBMT versus BMT. Donor-derived cells could be detected in VBMT recipients at 30 and 60 days but not in recipients of intravenous suspension of BMC. VBMT provides a theoretical alternative to conventional cellular bone marrow tr...

Punctal occlusion is safe and efficient for the treatment of keratoconjunctivitis sicca in patients with ocular GvHD

Bone Marrow Transplantation — Mon, 31 Oct 2011 04:00:00 +0100

Authors: S Sabti, J P Halter, B C Braun Fränkl & D Goldblum (Source: Bone Marrow Transplantation)

Differences in mothers’ and fathers’ psychological distress after pediatric SCT: a longitudinal study

Bone Marrow Transplantation — Mon, 31 Oct 2011 04:00:00 +0100

Differences in mothers’ and fathers’ psychological distress after pediatric SCT: a longitudinal study Bone Marrow Transplantation advance online publication, October 31, 2011. doi:10.1038/bmt.2011.206 Authors: M Barrera, E Atenafu, J Doyle, D Berlin-Romalis & K Hancock (Source: Bone Marrow Transplantation)

Subset characterization of myeloid-derived suppressor cells arising during induction of BM chimerism in mice

Bone Marrow Transplantation — Mon, 31 Oct 2011 04:00:00 +0100

Authors: A Luyckx, E Schouppe, O Rutgeerts, C Lenaerts, C Koks, S Fevery, T Devos, D Dierickx, M Waer, J A Van Ginderachter & A D Billiau (Source: Bone Marrow Transplantation)