MedWorm: Breast Lumpectomy

Accelerated Partial Breast Irradiation Using Once-Daily Fractionation: Analysis of 312 Cases with Four Years Median Follow-Up

Radiation Oncology — Mon, 06 Feb 2012 05:00:00 +0100

Conclusions: External beam APBI with once daily fractionation has a low rate of IBF consistent with other published APBI studies. The ASTRO risk stratification did not differentiate a subset of patients with a higher rate of IBF. APBI may be an appropriate treatment for women with DCIS and ILC. (Source: Radiation Oncology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Is it possible to prevent repeat lumpectomies?

Health Facts and Fears — Thu, 02 Feb 2012 05:00:00 +0100

Nearly a quarter of breast cancer patients who undergo a lumpectomy — also commonly referred to as a partial mastectomy — will have to return for repeat surgery, according to the results of a recent study published in the Journal of the American Medical Association. (Source: Health Facts and Fears)

Repeat Breast Cancer Surgery Guidelines Found Unclear

NYT Health — Tue, 31 Jan 2012 21:29:37 +0100

A study suggests that some lumpectomy patients undergo second operations that they do not need and others might need surgery that they do not get. (Source: NYT Health)

Lumpectomy Often Not End of Story (CME/CE, with video)

MedPage Today Hematology/Oncology — Tue, 31 Jan 2012 21:12:12 +0100

(MedPage Today) -- Almost a quarter of breast cancer lumpectomies are followed by revision surgery, although that rate varies widely across surgeons and centers. (Source: MedPage Today Hematology/Oncology)

Breast Cancer Surgery Rules Are Called Unclear Saint Mary's Health Care

RWJF News Digest - Quality/Equality — Tue, 31 Jan 2012 05:00:00 +0100

Nearly half of women who had lumpectomies for breast cancer had second operations they may not have needed because surgeons have been unable to agree on guidelines for the most common operation for breast cancer, a new study finds. (Source: RWJF News Digest - Quality/Equality)

Validating Fiducial Markers for Image-Guided Radiation Therapy for Accelerated Partial Breast Irradiation in Early-Stage Breast Cancer

International Journal of Radiation Oncology * Biology * Physics — Mon, 30 Jan 2012 09:33:53 +0100

Conclusion: Fiducial markers are stable throughout the course of APBI. Planning target volume margins when using bony landmarks should be 10 mm and can be reduced to 6 mm if using fiducials. (Source: International Journal of Radiation Oncology * Biology * Physics)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Natural Breast Augmentation or Fat Transfer: The Mammographic and Sonographic Correlation

Journal of Diagnostic Medical Sonography — Wed, 25 Jan 2012 05:00:00 +0100

Natural breast augmentation, or fat transfer, involves taking fat cells from one area of the body and injecting them into another area, such as the breast. This can be done for cosmetic reasons after a lumpectomy or other surgical procedures that affect the shape of the breast. Breast augmentation is also being used electively by some women to enhance the appearance of their breasts. Defects such as asymmetry, sagging, or indentations have been improved with fat transfers. The changes of the breast tissue from the reaction to the new fat can also change the outcome of mammograms and sonograms. The interpreting radiologist might recommend a biopsy to exclude the possibility of missing a malignant lesion. These two case reports give sonographers an idea of what additional questions they may ...

Reducing interobserver variation of boost-CTV delineation in breast conserving radiation therapy using a pre-operative CT and delineation guidelines.

Fri, 20 Jan 2012 05:00:00 +0100

CONCLUSION: Use of a Preop-CT in BCT results in a modest but statistically significant reduction in interobserver variation of the boost-CTV delineations and in a significant reduction in the boost-CTV volume. PMID: 22265730 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)

Repeat Lumpectomy for Ipsilateral Breast Tumor Recurrence after Breast-Conserving Treatment.

Oncology — Fri, 20 Jan 2012 05:00:00 +0100

Conclusion: The ER status of IBTR was a significantly independent predictive factor for second IBTR-free survival. Some patients could safely undergo repeat lumpectomy for IBTR. PMID: 22269927 [PubMed - as supplied by publisher] (Source: Oncology)

The Postconservation Breast: Part 1, Expected Imaging Findings

American Journal of Roentgenology — Thu, 19 Jan 2012 05:00:00 +0100

CONCLUSION. Imaging the treated breast presents challenges because of its limited compressibility and the overlapping features of benign posttreatment alterations and tumor recurrence. After lumpectomy and radiation therapy, mammographic findings such as breast edema, skin thickening, fluid collections, architectural distortion, and calcifications have characteristic sequences of evolution toward stability. Awareness of these normal chronologic imaging findings for the conservatively treated breast minimizes unnecessary recall from screening and permits early detection of recurrent breast carcinoma. (Source: American Journal of Roentgenology)

The Postconservation Breast: Part 2, Imaging Findings of Tumor Recurrence and Other Long-Term Sequelae

American Journal of Roentgenology — Thu, 19 Jan 2012 05:00:00 +0100

CONCLUSION. Imaging the treated breast presents challenges because of its limited compressibility and overlapping features of benign posttreatment alterations and tumor recurrence. After lumpectomy and radiation therapy, mammographic findings such as breast edema, skin thickening, fluid collections, architectural distortion, and calcifications have characteristic sequences of evolution toward stability. Changes in the imaging appearance after stability has been achieved—including increasing asymmetry, an enlarging mass, increasing edema or skin thickening, and the development of pleomorphic calcifications within or near the operative bed—should alert the radiologist to possible tumor recurrence. When mammography or sonography is indeterminate, MRI may be useful in excluding rec...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Triple negative breast cancer is associated with an increased risk of residual invasive carcinoma after lumpectomy

Cancer — Tue, 03 Jan 2012 05:00:00 +0100

CONCLUSION:TN subtype has a statistically significant association with an increased risk of residual tumor. This suggests the putative increase in the risk of local failure in TN patients may be related to increased residual tumor burden. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer)

Novel imaging device tells breast surgeons if they've left any tumor behind

Modern Medicine — Fri, 09 Dec 2011 05:00:00 +0100

NEW YORK (Reuters Health) - A new ultrasound device (MarginProbe, Dune Medical Devices, Inc.) helps improve the surgeon's ability to complete lumpectomy in one procedure, according to data presented this week at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium in Texas. (Source: Modern Medicine)

Brachytherapy Doubles Mastectomy Risk And Complications

Health News from Medical News Today — Thu, 08 Dec 2011 22:00:00 +0100

A breast cancer patient who undergoes brachytherapy has double the chance of losing her breasts compared to one who is treated with whole-breast irradiation, researchers from the MD Anderson Cancer Center, Houston, explained at SABCS (34th Annual San Antonio Breast Cancer Symposium). Brachytherapy is radiation treatment given by placing radioactive material directly in (or near) the target. Brachytherapy simply means internal radiation therapy. For breast cancer patients, a small radioactive source is placed inside the breast after lumpectomy... (Source: Health News from Medical News Today)

Predicting Risk For Recurrence For Patients With DCIS Breast Cancer

Health News from Medical News Today — Thu, 08 Dec 2011 08:00:00 +0100

In a significant advance for patients with ductal carcinoma in situ, researchers have developed and prospectively validated a multigene test to identify the risk for recurrence of breast cancer. The method combines measuring tumor gene expression with a gene expression algorithm to decipher the genetic underpinnings of a patient's cancer and determine whether the individual patient should be treated with surgery (usually lumpectomy) or a combination of surgery and radiation... (Source: Health News from Medical News Today)

Giuliana Rancic to undergo double mastectomy

CNN.com - Health — Mon, 05 Dec 2011 15:36:17 +0100

Giuliana Rancic will have a double mastectomy after lumpectomies failed to completely eradicate her breast cancer. (Source: CNN.com - Health)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

SABCS: New Multigene Test Predicts Recurrence Risk for DCIS

About.com Breast Cancer — Mon, 05 Dec 2011 05:00:00 +0100

News from the 34th Annual San Antonio Breast Cancer Symposium (SABCS): Dr. Lawrence Solin presented the results of a study for a new multigene assay which has been shown to predict the risk of recurrence for patients with ductal carcinoma in situ - DCIS - a precancerous breast condition. Standard treatment for DCIS is a lumpectomy and radiation, followed by five years of hormone therapy, if the cells were estrogen-sensitive. This new test helps a doctor determine which patients need radiation to prevent a recurrence, and which may safely avoid that treatment....Read Full Post (Source: About.com Breast Cancer)

Breast Cancer Q&A with Lisa Tolnitch, MD

DukeHealth.org: Duke Health Features — Thu, 01 Dec 2011 18:52:59 +0100

Lisa Tolnitch, MD, of Duke Cancer Institute answers questions about breast cancer. Can calcifications in the breast turn into cancer? Calcifications on mammography do not themselves turn into cancer. They can be a marker especially in certain patterns of an evolving cancer. Worrisome features are pleomorphic calcifications (different sizes and shapes in a group), branching forms (following the branches of a milk duct), or casting calcifications. Those features usually require a biopsy under mammogram guidance with a core needle. Is a mastectomy always the best option to treat breast cancer? Mastectomy is an option for surgical treatment. If a tumor is small, less than 4 centimeters, and does not have locally advanced features such as skin involvement, a patient can have a lumpectomy with...

Methylene Blue Dye-Related Changes in the Breast After Sentinel Lymph Node Localization

Journal of Ultrasound in Medicine — Mon, 28 Nov 2011 05:00:00 +0100

Conclusions— After sentinel lymph node localization using methylene blue dye, breast sonography can show unexplained focal lesions in the periareolar and retroareolar regions. Although most of the changes suggest fat necrosis, an irregular parenchymal mass can develop and mimic a recurrence. (Source: Journal of Ultrasound in Medicine)

Breast Cancer Q&A with Lisa Tolnitch, MD

DukeHealth.org: Duke Health Features — Fri, 25 Nov 2011 18:19:42 +0100

Twenty-five year results of the national cancer institute randomized breast conservation trial

Breast Cancer Research and Treatment — Wed, 23 Nov 2011 17:36:16 +0100

Abstract Breast conservation therapy (BCT) consisting of lumpectomy and postoperative radiation has become an accepted alternative to mastectomy (MRM) for the treatment of early stage breast cancer. We currently report the 25 year outcomes of a single institution, prospective, randomized clinical trial at the National Cancer Institute. 237 women with pathologically confirmed invasive breast tumors 5 cm or less were accrued between 1979 and 1987 and randomized to receive either BCT or MRM. Overall survival was the primary endpoint. Patients with node positive disease were included and treated with doxorubicin and cyclophosphamide. Both arms received axillary dissection. BCT patients had radiation to the whole breast followed by a boost. At a median follow-up of 25...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Breast Cancer Treatment Practices in Elderly Women in a Community Hospital

Comparative and Functional Genomics — Thu, 17 Nov 2011 17:30:47 +0100

Conclusions. Surgery was performed in majority of these patients, about half received lumpectomy, the other half mastectomy. Adjuvant therapies were frequently excluded, with only hormonal therapy being the most commonly used. Overall five-year survival is significantly worse in patients ≥80 years with breast cancer. (Source: Comparative and Functional Genomics)

Re: Long-term Outcomes of Invasive Ipsilateral Breast Tumor Recurrences After Lumpectomy in NSABP B-17 and B-24 Randomized Clinical Trials for DCIS

JNCI — Tue, 15 Nov 2011 05:00:00 +0100

(Source: JNCI)

Why Did Wanda Sykes Get a Double Mastectomy?

Dr. Weil Q and A — Mon, 14 Nov 2011 15:27:01 +0100

I was shocked to hear that actress and comedienne Wanda Sykes had a double mastectomy for what she said was early breast cancer. Couldn't she have had a lumpectomy instead? (Source: Dr. Weil Q and A)

Painful Palpable Area in Right Breast Accompanied by a Straw-Colored Nipple Discharge in 22-Year-Old Woman

Cancer Network — Tue, 08 Nov 2011 12:00:00 +0100

A 22-year-old female collegiate soccer player complains of a painful palpable area in her right breast accompanied by a straw-colored nipple discharge. Because she is extremely anxious and has had previous excisional biopsies, you decide to perform a lumpectomy. (Source: Cancer Network)

Comparative Acute Toxicity from Whole Breast Irradiation Using 3-Week Accelerated Schedule With Concomitant Boost and the 6.5-Week Conventional Schedule With Sequential Boost for Early-Stage Breast Cancer.

Clinical Breast Cancer — Fri, 04 Nov 2011 04:00:00 +0100

CONCLUSION: Our observations suggest that there is acceptable toxicity with the accelerated schedule as used in this study. Further, it is not associated with a higher risk of acute toxicity when compared with the conventional schedule. Patients in the study are being followed, and clinical outcomes will be reported as the data mature. PMID: 22056970 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Comparative Study of Surgical Margins and Cosmetic Outcome in Lumpectomy versus Segmental Resection in Breast Cancer

European Surgical Research — Tue, 01 Nov 2011 23:00:00 +0100

Eur Surg Res 2011;47:231–239 (DOI:10.1159/000333090) (Source: European Surgical Research)

Surgical Drains Location

About.com Breast Cancer — Sun, 30 Oct 2011 04:00:00 +0100

Surgical drains are one of the things you may have to deal with after a mastectomy or lumpectomy. Surgical drains are located where they will aid the healing process. Learn more about the location of post-mastectomy surgical drains here. (Source: About.com Breast Cancer)

Nipple Sparing Mastectomy

Health News from Medical News Today — Sat, 29 Oct 2011 07:00:00 +0100

A new study suggests some women needing a lumpectomy or mastectomy to treat their breast cancer have another potential option that is safe and effective, say researchers at Georgetown. They say the procedure known as a nipple sparing mastectomy is also a viable surgical option for women who choose to have their breasts removed because of their increased risk of developing the disease. For both groups of women, the surgery offers a chance for a more natural looking and normal feeling reconstructed breast as compared to other forms of mastectomy... (Source: Health News from Medical News Today)

Nipple Sparing Mastectomy gives Breast Cancer Patients A Third Safe Surgery Option

Health News from Medical News Today — Thu, 27 Oct 2011 18:00:00 +0100

A new study published in the journal Plastic and Reconstructive Surgery found that some women who need a lumpectomy or mastectomy have a third, perfectly safe option for treatment. The NSM or Nipple Sparing Mastectomy. There are essentially two main paths for surgery when breast cancer is detected. The first less aggressive is just to remove the lump and the tissue around it (lumpectomy). The second is to remove the entire breast... (Source: Health News from Medical News Today)

Researchers examine 21-year series of nipple sparing mastectomy cases and find no cancers

ScienceDaily Headlines — Thu, 27 Oct 2011 12:30:30 +0100

A new study suggests some women needing a lumpectomy or mastectomy to treat their breast cancer have another potential option that is safe and effective -- nipple sparing mastectomy. A long standing concern with this type of surgery is that cancer cells might be left under the nipple, posing a threat over time. To examine the effectiveness of NSM, surgeons conducted a review of patient records for all women receiving the surgery at Georgetown University Hospital between 1989 and 2010. (Source: ScienceDaily Headlines)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Georgetown researchers examine 21-year series of nipple sparing mastectomy cases and find no cancers

EurekAlert! - Medicine and Health — Thu, 27 Oct 2011 04:00:00 +0100

(Georgetown University Medical Center) A new study suggests some women needing a lumpectomy or mastectomy to treat their breast cancer have another potential option that is safe and effective -- nipple sparing mastectomy. A long standing concern with this type of surgery is that cancer cells might be left under the nipple, posing a threat over time. To examine the effectiveness of NSM, surgeons conducted a review of patient records for all women receiving the surgery at Georgetown University Hospital between 1989 and 2010. (Source: EurekAlert! - Medicine and Health)

Radiotherapy after surgery halves the chance of breast cancer returning

the Mail online | Health — Fri, 21 Oct 2011 12:10:13 +0100

Radiation treatment after breast cancer surgery halves the chances of the disease recurring among women who have had lumpectomies, says a ten-year study by Oxford scientists. (Source: the Mail online | Health)

Breast cancer study shows radiation cuts recurrence, ups survival

Health News: CBSNews.com — Thu, 20 Oct 2011 13:57:08 +0100

Study shows radiotherapy after lumpectomy boosts survival over long term, not just immediately following surgery (Source: Health News: CBSNews.com)

Breast Radiation After Lumpectomy Saves Lives: Study

MedicineNet Cancer General — Thu, 20 Oct 2011 07:00:00 +0100

Title: Breast Radiation After Lumpectomy Saves Lives: StudyCategory: Health NewsCreated: 10/19/2011 8:06:00 PMLast Editorial Review: 10/20/2011 (Source: MedicineNet Cancer General)

Breast Radiation After Lumpectomy Saves Lives

MedlinePlus Health News — Wed, 19 Oct 2011 23:00:00 +0100

Recurrence rate halved compared to those who undergo breast-conserving surgery alone, research shows Source: HealthDay Related MedlinePlus Pages: Breast Cancer, Mastectomy, Radiation Therapy (Source: MedlinePlus Health News)

A case of femoral diaphyseal fracture after long-term treatment with zoledronic acid.

Breast Cancer — Wed, 19 Oct 2011 04:00:00 +0100

We report here a case of femoral diaphyseal fracture thought to be caused by oversuppression of bone remodeling due to long-term bisphosphonate treatment. The patient was a 63-year-old postmenopausal woman. She had undergone left lumpectomy and sentinel node biopsy for left breast cancer at age 57. The case was diagnosed as pT2N0M0, stage IIA breast cancer. The biopsy sample was positive for hormone receptors and negative for HER2 protein. Postoperatively, exemestane was administered as adjuvant therapy. Right axillary lymph node metastasis was found at age 59, and right axillary lymph node dissection was performed. Postoperatively, epirubicin/cyclophosphamide and paclitaxel were administered. Subsequently, letrozole was administered. However, bone metastases to the first thoracic vertebra...

Management of non metastatic phyllodes tumors of the breast: Review of the literature

Surgical Oncology — Thu, 13 Oct 2011 00:45:02 +0100

Abstract: Phyllodes tumors of the breast are rare tumors, accounting for less than 0.5% of all breast tumors. These tumors are comprised of both stromal and epithelial elements; and traditionally they are graded by the use of a set of histologic features into benign, borderline, and malignant subtypes. Unfortunately, the histologic classification of phyllodes tumors does not reliably predict clinical behavior.The mainstay of treatment of non metastatic phyllodes tumors of the breast is complete surgical resection with wide resection margins. Lumpectomy or partial mastectomy is the preferred surgical therapy. However, despite the complete surgical resection, local failure rate may be high; and 22% of malignant tumors may give rise to haematogenous metastases. The most frequent site of dista...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Dance/movement therapy for improving psychological and physical outcomes in cancer patients.

Cochrane Database of Systematic Reviews — Tue, 11 Oct 2011 01:20:04 +0100

CONCLUSIONS: We did not find support for an effect of dance/movement therapy on body image. The findings of one study suggest that dance/movement therapy may have a beneficial effect on QoL. However, the limited number of studies prevents us from drawing conclusions concerning the effects of dance/movement therapy on psychological and physical outcomes in cancer patients. PMID: 21975762 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Bilateral primary breast neuroendocrine carcinoma in a young woman: Report of a case

Surgery Today — Tue, 04 Oct 2011 05:59:02 +0100

Abstract Bilateral breast carcinoma accounts for approximately 5% of all patients with breast cancer, while neuroendocrine breast carcinomas comprise less than 5% of invasive breast carcinomas. In addition, most patients with breast neuroendocrine carcinomas are older. Therefore, bilateral primary breast neuroendocrine carcinoma at a young age is extremely rare. We herein report bilateral neuroendocrine carcinoma of the breast in a 29-year-old woman who underwent bilateral lumpectomy with the initial symptom of bilateral nipple discharge. Grossly, the lesions in both breasts were masses with infinite margins. Histologically, this case was consistent with primary neuroendocrine carcinoma arising in bilateral breasts. Cells from both breast tumors were positive for chromogra...

Surgical treatment of intracystic carcinoma of the breast

World Journal of Surgical Oncology — Tue, 04 Oct 2011 04:00:00 +0100

Conclusion: When it is difficult to diagnose intracystic carcinoma of the breast by fine needle aspiration, active lumpectomy is necessary. Because extramural invasion and lymph node metastasis have been reported, it is necessary to carefully determine the range of excision and rationally perform lymph node dissection, such as sentinel node biopsy. (Source: World Journal of Surgical Oncology)

High resolution intra-operative two-dimensional specimen mammography and its impact on second operation for re-excision of positive margins at final pathology after breast conservation surgery

American Journal of Surgery — Mon, 26 Sep 2011 15:52:45 +0100

Abstract: Background: In the United States, about 50% to 66% of women undergoing breast conservation surgery for cancer undergo subsequent mastectomy for positive margins on initial lumpectomy. This is despite the fact that screening mammography has resulted in a decrease in the size of newly diagnosed breast cancer to (Source: American Journal of Surgery)

Is There a Low-Grade Precursor Pathway in Breast Cancer?

Annals of Surgical Oncology — Wed, 21 Sep 2011 05:54:13 +0100

Conclusions These data do not support a low-grade precursor pathway characterized by LCIS and LG-DCIS. ER/PR and HER2 status have a high rate of concordance between in situ and subsequent invasive lesions. Additional studies of metachronous in situ and invasive lesions are needed to better understand pathways of breast tumorigenesis. Content Type Journal ArticleCategory Breast OncologyPages 1-7DOI 10.1245/s10434-011-2053-0Authors Tari A. King, Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, USARita A. Sakr, Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, USAShirin Muhsen, Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, USAVictor P. Andrade, Brea...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Coexistence of breast cancer and tuberculosis in axillary lymph nodes: a case report and literature review

Breast Cancer Research and Treatment — Wed, 21 Sep 2011 05:50:38 +0100

Abstract Coexistence of breast cancer and tuberculosis (TB) of the breast and/or axillary lymph nodes is uncommon. In this article, we present a case of tuberculous axillary lymphadenitis existing simultaneously with invasive ductal carcinoma of the left breast. We also conducted an extensive literature review of English language studies published on the coexistence of breast cancer and TB of the breast and/or axillary lymph nodes from 1899 to 2011 using the PubMed and Google Scholar databases. Twenty-nine cases of coexisting breast cancer and TB of the breast and/or axillary lymph nodes have been published to date, including a 74-year-old female diagnosed with left breast cancer and TB of the axillary lymph nodes. A tumor in the right breast was detected in 14 patients an...

Accelerated Hypofractionated Adjuvant Whole Breast Radiotherapy with Concomitant Photon Boost after Conserving Surgery for Early Stage Breast Cancer: A Prospective Evaluation on 463 Patients

The Breast Journal — Wed, 21 Sep 2011 04:00:00 +0100

Abstract: The current standard therapeutic option for early stage breast cancer (EBC) employs a multimodality treatment approach including conservative surgery, radiotherapy, chemotherapy, and hormone therapy. The most common adjuvant radiotherapeutic strategy consists of external beam radiation therapy (EBRT) delivered to the whole breast using 1.8–2 Gy fractions given five times a week, up to a total dose of 45–50 Gy over a period of 5 weeks. In recent years, altered schedules employing larger dose per fraction delivered in fewer treatment sessions over a shorter overall treatment time began to be explored. We herein present clinical data on accelerated hypofractionated adjuvant whole‐breast radiotherapy delivered on a daily basis for a total treatment time of 20 fractions...

Radiologic Features of Granulomatous Mastitis

The Breast Journal — Mon, 19 Sep 2011 04:00:00 +0100

In this study, we present the imaging features of a series of 10 cases with proved diagnosis of granulomatous mastitis with emphasis on magnetic resonance (MR) findings. All those patients who were histologically proven to have GM of the breast were analyzed. Their files were reviewed and data recorded for demographic, clinical presentation and imaging appearances. The imaging features of the lesions by mammography, ultrasound, and magnetic resonance imaging were analyzed. Of the 305 patients who were surgically treated, 10 (3%) cases proved to have GM. All the patients were females with age ranging from 27 to 53 years (average 38 years and median age 36 years). Guided core biopsy was performed in all cases for confirmation of diagnosis followed by either excision biopsy (in five cas...

The rs12975333 variant in the miR-125a and breast cancer risk in Germany, Italy, Australia and Spain

Journal of Medical Genetics — Mon, 19 Sep 2011 04:00:00 +0100

The rare variant rs12975333 is a G->T change located at the eighth nucleotide of the mature microRNA-125a (miR-125a). The T allele has been reported to block the processing of pri-miRNA to pre-miRNA precursor and to be extremely rare, being detected only once in a panel of 1200 individuals from diverse ethnic backgrounds assessed by the Centre d'Etude du Polymorphisme Humain.1 A study by Li et al2 showed the T allele of rs12975333 to be strongly associated with breast cancer risk, with 6 of 72 (8.3%) breast cancer cases from two hospitals in Antwerp, Belgium, being carriers of the T allele and none of 282 controls collected from the general population in the Antwerp area or 587 Caucasian controls collected in the USA.2 The breast cancers were all lymph node negative and received only lo...

MBCS: Recurrence of Breast Cancer No Less if Chemo First

MedPage Today Hematology/Oncology — Tue, 13 Sep 2011 17:00:00 +0100

SAN FRANCISCO (MedPage Today) -- Timing of chemotherapy may not be as important as tumor characteristics in outcomes after lumpectomy for breast cancer, researchers found. (Source: MedPage Today Hematology/Oncology)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Readers Respond to "The Growing Menace from Superweeds" and Other Articles

Scientific American - Official RSS Feed — Fri, 09 Sep 2011 14:00:00 +0100

CAUGHT TOO EARLY In discussing the search for better detection of breast cancer in “ Beyond Mammograms ,” Nancy Shute misses one key problem: when tests become too “perfect.” As we have learned from our experience in detecting prostate cancer by testing for high levels of the prostate-specific antigen protein, finding cancers at extraordinarily early stages raises new issues. Are we now left to treat cancers that have no clinical relevance? We already often diagnose breast cancers at one to three millimeters in size. Do women with such cancers need radiation and hormone therapy for five years after a lumpectomy? Is performing a mastectomy too radical in such cases? I believe the future of cancer therapy is getting a much better grasp of the malignant potential of th...

Feasibility of Percutaneous Excision Followed by Ablation for Local Control in Breast Cancer

Annals of Surgical Oncology — Fri, 09 Sep 2011 06:00:08 +0100

Conclusions This pilot study demonstrates the feasibility of a novel approach to minimally invasive therapy: percutaneous excision and effective cytoreduction, followed by radiofrequency ablation of margins for the treatment of breast cancer. Laser treatment requires further improvement. Content Type Journal ArticleCategory American Society of Breast SurgeonsPages 1-9DOI 10.1245/s10434-011-2002-yAuthors V. Suzanne Klimberg, Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences, Winthrop P. Rockefeller Cancer Institute, Little Rock, AR, USACristiano Boneti, Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences, Winthrop P. Rockefeller Cancer Institute, Little Rock, A...

Young Women With Early Breast Cancer Have Similar Survival With Breast Conservation, Mastectomy

Health News from Medical News Today — Thu, 08 Sep 2011 10:00:00 +0100

Young women with early-stage breast cancer have similar survival rates with a lumpectomy and radiation treatment, known as breast-conservation therapy, as with mastectomy, a new study conducted at the University of Maryland has found. The results of the analysis of nearly 15,000 patients listed in a nationwide cancer registry will be presented at the 2011 Breast Cancer Symposium to be held Sept. 8-11 in San Francisco. Steven J. Feigenberg, M.D... (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Lumpectomy as good as mastectomy in younger women

Health Facts and Fears — Thu, 08 Sep 2011 04:00:00 +0100

Two new studies have discredited the common belief that mastectomy should be the standard treatment for breast cancer in women under 40. (Source: Health Facts and Fears)

Role of Science in the Treatment of Breast Cancer When Tumor Multicentricity is Present

JNCI — Thu, 08 Sep 2011 04:00:00 +0100

During the past 100 years, there have been two major controversies with regard to the treatment of primary breast cancer. The first controversy, which occurred approximately 35 years ago, questioned the performance of radical mastectomy, as originally proposed by Halsted in the 1890s. That controversy was resolved by the use of laboratory and clinical research, hypothesis formulation, and evaluation of the efficacy of the latter through the conduct of randomized clinical trials. A second major controversy arose when magnetic resonance imaging began to detect the presence of tumor multicentricity in many breast cancer patients, resulting in a resurgence in mastectomy in women who could have been treated with breast-preserving surgery. Because the use of science resolved the first controvers...

MBCS: Lumpectomy 'Safe' for Young Breast Cancer Patients (with audio)

MedPage Today OB/GYN — Wed, 07 Sep 2011 19:55:05 +0100

SAN FRANCISCO (MedPage Today) -- Lumpectomy doesn't carry higher recurrence or mortality risk than mastectomy for young women with breast cancer, two separate studies found. (Source: MedPage Today OB/GYN)

For Young Breast Cancer Patients, Breast-Conserving Therapy Appears Effective

The Doctors Lounge - Health News — Wed, 07 Sep 2011 00:00:00 +0100

Two studies find similar survival for women under 40 with a lumpectomy or a mastectomy (Source: The Doctors Lounge - Health News)

Mastectomy Offers No Survival Advantage in Young WomenMastectomy Offers No Survival Advantage in Young Women

Medscape Today Headlines — Tue, 06 Sep 2011 22:28:49 +0100

In young women with early breast cancer, lumpectomy appears to be a safe choice. Medscape Medical News (Source: Medscape Today Headlines)

Light‐guided lumpectomy: first clinical experience

Journal of Biophotonics — Wed, 31 Aug 2011 23:00:00 +0100

We report on the early use of light‐guided lumpectomy. Eight patients with non‐palpable breast cancer undergoing lumpectomy for biopsy‐proven and radiographically identifiable cancer were enrolled in the study. An optical wire was designed that incorporated a standard hook‐wire with an optical fiber. The optical wire was placed in the same manner as a standard hook‐wire. During light‐guided lumpectomy, an eye‐safe laser illuminated the optical wire and created a sphere of light surrounding the cancer. The light was visible at the beginning of each surgery and facilitated approaching the cancer without using the wire. Dissection around the sphere of light kept the wire tip within the surgical specimen. Three of eight initial surgical specimens had focally positive margins. Add...

Ultrasound-Guided Lumpectomy for Palpable Breast Cancers

Annals of Surgical Oncology — Tue, 23 Aug 2011 05:56:02 +0100

Conclusions Although palpable breast cancers can be excised based on direct palpation or needle localization, we believe that US guidance provides an excellent tool to aid the breast surgeon. Only 10% of patients had a positive margin on final pathology as a result, and the overall re-excision rate was acceptable. Content Type Journal ArticleCategory American Society of Breast SurgeonsPages 1-6DOI 10.1245/s10434-011-1958-yAuthors Carla S. Fisher, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USAFatema Al Mushawah, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USAAmy E. Cyr, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USAFeng Gao, Division of Biostatistics, Washing...

Cost-Effectiveness Analysis of Routine Frozen-Section Analysis of Breast Margins Compared with Reoperation for Positive Margins

Annals of Surgical Oncology — Tue, 23 Aug 2011 05:55:58 +0100

Conclusion Routine use of frozen-section analysis of lumpectomy margins decreases reoperation rates for margin control; therefore, the cost to provider and payor can be cost effective. Content Type Journal ArticleCategory American Society of Breast SurgeonsPages 1-6DOI 10.1245/s10434-011-1956-0Authors John B. Osborn, Department of Surgery, Mayo Clinic, Rochester, MN, USAGary L. Keeney, Department of Laboratory Medicine/Pathology, Mayo Clinic, Rochester, MN, USAJames W. Jakub, Department of Surgery, Mayo Clinic, Rochester, MN, USAAmy C. Degnim, Department of Surgery, Mayo Clinic, Rochester, MN, USAJudy C. Boughey, Department of Surgery, Mayo Clinic, Rochester, MN, USA Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 1068-9265 (Source: Annals o...

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Can we know what to do when DCIS is diagnosed?

Oncology (Williston Park, N.Y.) — Mon, 01 Aug 2011 04:00:00 +0100

Authors: Sanders ME, Simpson JF Abstract Utilizing routine histopathologic parameters obtained from appropriately handled lumpectomy and mastectomy specimens, a rational therapeutic plan based on epidemiologic and outcome-based data can be devised for any patient diagnosed with ductal carcinoma in situ (DCIS). In order to make a sound decision when weighing the current treatment options for DCIS--which include excision alone, excision plus radiation, and mastectomy--the following are mandatory: 1) assurance of an accurate diagnosis, 2) assessment of DCIS size and grade, and 3) careful margin evaluation. Accurate grading of DCIS is critical, since high nuclear grade and the presence of necrosis are highly predictive of the inability to achieve adequate margins, of local recurrence, ...

Bilateral Liponecrotic Pseudocysts After Breast Augmentation by Fat Injection: A Case Report

Aesthetic Plastic Surgery — Sat, 30 Jul 2011 05:58:53 +0100

This article aims to describe bilateral liponecrotic pseudocysts after injection of fat into the breast. A 42-year-old woman presented with palpable indurations and pain with pressure. She also showed abnormalities on her breast cancer screening. The woman underwent mammography, magnetic resonance imaging, and pathologic confirmation to evaluate the breast abnormalities. These radiologic examinations were consistent with liponecrotic pseudocysts on both sides. Bilateral lumpectomies were performed through an inframammary approach. Histologic examination of the specimens showed fat necrosis and dystrophic calcification. Autologous fat grafting to the breast is not a simple procedure and should be performed by well-trained and skilled plastic surgeons. During the surgery, caution shoul...

A Comparison of Surgical Complications Between Immediate Breast Reconstruction and Mastectomy: The Impact on Delivery of Chemotherapy—An Analysis of 391 Procedures

Annals of Surgical Oncology — Wed, 27 Jul 2011 05:48:34 +0100

Conclusions Although the incidence of overall and major postoperative complications was higher after IBR than mastectomy alone, there were no significant relationships in the multivariable analysis. IBR was associated with a modest increase in time to chemotherapy that was statistically but not clinically significant. Content Type Journal ArticlePages 1-7DOI 10.1245/s10434-011-1950-6Authors Toni Zhong, Division of Plastic and Reconstructive Surgery, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, CanadaStefan O. P. Hofer, Division of Plastic and Reconstructive Surgery, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, CanadaDavid R. McCready, Department of Surgical Oncology, Department of Surg...

Molecular Class as a Predictor of Locoregional and Distant Recurrence in the Neoadjuvant Setting for Breast Cancer.

Oncology — Mon, 25 Jul 2011 23:00:00 +0100

Conclusions: IHC subclassification and pCR predict distant failure, DFS, and OS in the neoadjuvant setting. While not predictive of locoregional recurrence, the total number of events were small. More work is needed to define if molecular class can predict patients at risk for locoregional recurrence. PMID: 21791944 [PubMed - as supplied by publisher] (Source: Oncology)

Adenoma of the nipple, focusing on the contrast-enhanced magnetic resonance imaging findings: Report of a case

Surgery Today — Tue, 19 Jul 2011 23:19:47 +0100

Abstract A woman in her 50s was referred to our hospital for an investigation of a right breast tumor. The tumor was palpated below the nipple, but there was no erosion or nipple discharge. Mammography showed a well-defined high-density tumor, measuring 2 cm in diameter, without calcification, and ultrasonography showed a low-echoic mass with a fluid component with posterior echo enhancement and a lateral shadow. Contrast-enhanced magnetic resonance imaging (CE-MRI) demonstrated a 1.3 × 0.8 cm solid component and a gradually increasing time-intensity curve. We performed lumpectomy and the pathological findings were adenoma of the nipple. The pattern of the time-intensity curve might be attributed to moderate fibrosis of the tumor. Contrasten-hanced MRI is therefore consid...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Indication for relumpectomy—a useful scoring system in cases of invasive breast cancer

Journal of Surgical Oncology — Tue, 19 Jul 2011 23:00:00 +0100

ConclusionsFor patients with surgical margins <2 mm and a score of <4, the probability of finding a residual invasive tumor is 0%, while the probability of finding a microfocus of <2 mm of invasive carcinoma is 3.2% and of finding residual DCIS is up to 10%. J. Surg. Oncol. © 2011 Wiley‐Liss, Inc. (Source: Journal of Surgical Oncology)

Increased Risk of Locoregional Recurrence for Women With T1-2N0 Triple-Negative Breast Cancer Treated With Modified Radical Mastectomy Without Adjuvant Radiation Therapy Compared With Breast-Conserving Therapy [Breast Cancer]

Journal of Clinical Oncology — Sun, 17 Jul 2011 23:00:00 +0100

Conclusion Women with T1-2N0 TNBC treated with MRM without RT have a significant increased risk of LRR compared with those treated with BCT. Prospective studies are warranted to investigate the benefit of adjuvant RT after MRM in TNBC. (Source: Journal of Clinical Oncology)

Ductal carcinoma in situ (DCIS) of the breast: Perspectives on biology and controversies in current management

Journal of Surgical Oncology — Mon, 11 Jul 2011 23:00:00 +0100

AbstractThe incidence of ductal carcinoma in situ (DCIS) has increased because of increasing use of sensitive imaging modalities. MRI is commonly used for the detection of breast cancer but has not yet been validated in randomized trials. There have not been randomized trials addressing optimal margins of excision or axillary sampling. Whole breast radiation after lumpectomy decreases the risk of recurrence but may be omitted in selected patients. Adjuvant Tamoxifen reduces the risk of recurrence but has no impact on overall survival rates. J. Surg. Oncol © 2011 Wiley‐Liss, Inc. (Source: Journal of Surgical Oncology)

Comparison of modulated electron radiotherapy to conventional electron boost irradiation and volumetric modulated photon arc therapy for treatment of tumour bed boost in breast cancer

Radiotherapy and Oncology — Thu, 07 Jul 2011 23:00:00 +0100

Abstract: Background and purpose: To compare few leaf electron collimator (FLEC)-based modulated electron radiotherapy (MERT) to conventional direct electron (DE) and volumetric modulated photon arc therapy (VMAT) for the treatment of tumour bed boost in breast cancer.Materials and methods: Fourteen patients with breast cancer treated by lumpectomy and requiring post-operative whole breast radiotherapy with tumour bed boost were planned retrospectively using conventional DE, VMAT and FLEC-based MERT. The planning goal was to deliver 10Gy to at least 95% of the tumour bed volume. Dosimetry parameters for all techniques were compared.Results: Dose evaluation volume (DEV) coverage and homogeneity were best for MERT (D98=9.77Gy, D2=11.03Gy) followed by VMAT (D98=9.56Gy, D2=11.07Gy) and DE (D98...

Photo Release -- Trinitas Comprehensive Cancer Center is First in New Jersey to Offer AccuBoost Technology

Medical News (via PRIMEZONE) — Wed, 06 Jul 2011 14:00:00 +0100

ELIZABETH, N.J., July 6, 2011 (GLOBE NEWSWIRE) -- Trinitas Comprehensive Cancer Center is the first cancer treatment facility in the state of New Jersey to offer its breast cancer patients AccuBoost radiotherapy technology, an image-guided, non-invasive form of treatment using technology from Nucletron. The accuracy and non-invasiveness of AccuBoost allows early stage breast cancer patients who have undergone a lumpectomy to retain more undamaged breast tissue, thus making a significant difference in patient outcomes. AccuBoost is also up to 50 percent more accurate than standard breast radiotherapy. (Source: Medical News (via PRIMEZONE))

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Comparison of modulated electron radiotherapy to conventional electron boost irradiation and volumetric modulated photon arc therapy for treatment of tumour bed boost in breast cancer.

Tue, 05 Jul 2011 23:00:00 +0100

CONCLUSIONS: MERT plans were a considerable improvement in dosimetry over DE boost plans. There was a dosimetric advantage in using MERT over VMAT for increased DEV conformity and low-dose sparing of healthy tissue including the integral dose; however, the cost is often an increase in the ipsilateral lung high-dose volume. PMID: 21741103 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)

Multiple miliary osteoma cutis of the face after initiation of alendronate therapy for osteoporosis.

Skinmed — Fri, 01 Jul 2011 04:00:00 +0100

Authors: Riahi RR, Cohen PR Abstract A 62-year-old Asian woman presented with multiple small, rock-hard papular lesions on her face (Figure). She had no previous history of acne vulgaris or cutaneous malignancy. She had been diagnosed with breast cancer in 1995 and was treated with left lumpectomy followed by combination chemotherapy consisting of cyclophosphamide, 5-fluorouracil, and methotrexate. In 1995, at age 50, she also began therapy with systemic alendronate to treat osteoporosis. Within 1 year, she noticed the development of asymptomatic indurated dermal papules on her cheeks. Topical treatment with 12% lactic acid lotion did not improve her condition. Clinical examination revealed numerous 1- to 2-mm, brown dermal nodules on the malar cheeks bilaterally. Normal laboratory...

Recurrence risk and margin status in granular cell tumors of the breast: a clinicopathologic study of 13 patients.

Archives of Pathology and Laboratory Medicine — Thu, 30 Jun 2011 23:00:00 +0100

Conclusion.-Granular cell tumors of the breast have little long-term risk for recurrence, even when excised with positive margins. Surgical evaluation after nonexcisional biopsy may still be indicated to assess for the possible association of colocalized carcinoma. PMID: 21732779 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

Percutaneous local ablation of unifocal subclinical breast cancer: clinical experience and preliminary results of cryotherapy

European Radiology — Fri, 17 Jun 2011 11:58:48 +0100

Conclusion The percutaneous cryoablation as a “minimally invasive” technique can provide excellent oncological and cosmetic results on selected cases handled by experienced operators by using the tested devices. Content Type Journal ArticlePages 1-10DOI 10.1007/s00330-011-2179-2Authors Guglielmo Manenti, Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, University Hospital “Tor Vergata”, viale Oxford 81, 00133 Rome, ItalyTommaso Perretta, Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, University Hospital “Tor Vergata”, viale Oxford 81, 00133 Rome, ItalyEleonora Gaspari, Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Ra...

Outcome of triple-negative breast cancer better with lumpectomy vs mastectomy

Modern Medicine — Thu, 16 Jun 2011 23:00:00 +0100

NEW YORK (Reuters Health) - Breast-conserving therapy may provide better five-year locoregional control for women with triple-negative breast cancer than modified radical mastectomy without adjuvant radiation, according to a retrospective study from Canada. (Source: Modern Medicine)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Partial Breast Irradiation Delivered With Proton Beam: Results of a Phase II Trial.

Clinical Genitourinary Cancer — Sat, 11 Jun 2011 23:00:00 +0100

CONCLUSION: Proton partial breast radiotherapy appeared to be a feasible method of treatment and provided excellent disease control within the ipsilateral breast. Treatment-related toxicity was minimal and no technical limitations prevented treatment delivery. The incidence of posttreatment complications may be less than that reported when using more invasive techniques; comparative trials should be considered. PMID: 21729673 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)

Long-term course of pain in breast cancer survivors: a 4-year longitudinal study

Breast Cancer Research and Treatment — Wed, 08 Jun 2011 15:45:35 +0100

Abstract After successful treatment of early breast cancer, many women still report pain symptoms, and attribute them to the previous illness or its treatment. However, knowledge about the long-term course of pain in breast cancer is limited. Baseline assessment included 3,088 women who received a breast cancer diagnosis on average 2 years prior to enrollment, and who completed typical medical treatments. After 4 years, a subsample of 2,160 recurrence-free women (70%) was re-assessed. The major outcome variable was the composite index for general pain symptoms. Over the 4-year course, a slight but significant increase in pain was reported. If only medical variables were examined, a triple interaction between surgery type, breast cancer stage, and time indicated t...

Limited-angle x-ray luminescence tomography: methodology and feasibility study.

Physics in Medicine and Biology — Tue, 07 Jun 2011 08:47:55 +0100

Authors: Carpenter CM, Pratx G, Sun C, Xing L X-ray luminescence tomography (XLT) has recently been proposed as a new imaging modality for biological imaging applications. This modality utilizes phosphor nanoparticles which luminesce near-infrared light when excited by x-ray photons. The advantages of this modality are that it uniquely combines the high sensitivity of radioluminescent nanoparticles and the high spatial localization of collimated x-ray beams. Currently, XLT has been demonstrated using x-ray spatial encoding to resolve the imaging volume. However, there are applications where the x-ray excitation may be limited by geometry, where increased temporal resolution is desired, or where a lower dose is mandatory. This paper extends the utility of XLT to meet these requirements ...

Practice-Changing Cancer Trial Shows Additional Radiation Decreases Cancer Recurrence, Canada

Health News from Medical News Today — Mon, 06 Jun 2011 09:00:00 +0100

A Canadian-led clinical trial has found that additional radiation treatment improves disease-free survival in women with early breast cancer and reduces the risk of cancer recurrence, a finding that could change the standard treatment for this group of patients. The trial was led by the NCIC Clinical Trials Group, which is funded by the Canadian Cancer Society. The study enrolled more than 1,800 women who had been treated with breast-conserving surgery (lumpectomy) and adjuvant chemotherapy or endocrine therapy... (Source: Health News from Medical News Today)

Adding Radiation Therapy Benefits Breast Cancer Surgery Patients

Health News from Medical News Today — Sun, 05 Jun 2011 12:00:00 +0100

Additional radiation treatment improves disease free survival lessening the chance of cancer recurring in women with early breast cancer who have had breast conserving surgery (lumpectomy), interim results of a new study found. The results will be presented Monday, June 6 at the annual meeting of the American Society of Clinical Oncology. "These results are potentially practice-changing," said Dr. Timothy J. Whelan, professor of oncology at McMaster University's Michael G... (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Breast cancer surgery patients benefit from adding radiation therapy

EurekAlert! - Medicine and Health — Sat, 04 Jun 2011 04:00:00 +0100

(McMaster University) Additional radiation treatment improves disease free survival lessening the chance of cancer recurring in women with early breast cancer who have had breast conserving surgery (lumpectomy), interim results of a new study found. (Source: EurekAlert! - Medicine and Health)

Feasibility of a Mindfulness-Based Stress Reduction Program for Early-Stage Breast Cancer Survivors

Journal of Holistic Nursing — Wed, 01 Jun 2011 23:00:00 +0100

Conclusions: Participants enrolled in the MBSR classes generally were compliant. Significant improvement in psychological status, symptoms, and QOL can be achieved with MBSR use in this population. (Source: Journal of Holistic Nursing)

The Safety of Multiple Re-excisions after Lumpectomy for Breast Cancer

Annals of Surgical Oncology — Wed, 01 Jun 2011 05:58:04 +0100

Conclusion Multiple re-excisions to obtain clear margins are a safe alternative to mastectomy for women with invasive cancer or DCIS. There is an acceptably low risk of local and systemic failure when negative margins are ultimately achieved. Content Type Journal ArticlePages 1-5DOI 10.1245/s10434-011-1802-4Authors Suzanne Coopey, Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USABarbara L. Smith, Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USAStephanie Hanson, Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USAJulliette Buckley, Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USAKevin S. Hughes, Department of Surgical Oncology, Massachusetts Gener...

Are patients with breast cancer satisfied with their decision making?

Clinical Journal of Oncology Nursing — Tue, 31 May 2011 23:00:00 +0100

This study allowed women to significantly participate in their care through surgical decision making, which improved satisfaction. Nurses are uniquely positioned to support women with early-stage breast cancer in their decision-making process. PMID: 21624867 [PubMed - in process] (Source: Clinical Journal of Oncology Nursing)

Breast Metastasis Of Primary Colon Cancer With Micrometastasis In The Axillary Sentinel Node: A Metastasis That Metastasized?

BioMed Central — Fri, 27 May 2011 23:00:00 +0100

In conclusion, solid cancers are able to further metastasize, via well-known pathways also recognized in primary cancers such as neoplastic cell invasion of peritumoral lymphatics. (Source: BioMed Central)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Prevalence and Predictors of Sleep Difficulty in a National Cohort of Women With Primary Breast Cancer Three to Four Months Postsurgery

Journal of Pain and Symptom Management — Fri, 27 May 2011 04:00:00 +0100

Conclusion: These findings indicate that a high proportion of women with breast cancer experience sleep difficulty. Depression and poorer physical functioning appear to be robust predictors of sleep difficulty, whereas other predictors may depend on sample characteristics, including menopausal status. (Source: Journal of Pain and Symptom Management)

Diagnosis and management of an unilateral giant fibroadenoma of the breast in pregnancy

Archives of Gynecology and Obstetrics — Tue, 24 May 2011 15:46:20 +0100

Conclusion We present a rare case of giant fibroadenoma in pregnant young women. Because of the progressive structural damage of the breast immediate surgical enucleation was indicated. Safety of the fetus was provided by perioperative monitoring. The pre-operative differentiation from phyllodes tumor is still challenging. Content Type Journal ArticlePages 1-3DOI 10.1007/s00404-011-1923-9Authors Thorsten Heilmann, Klinik für Gynäkologie und Geburtshilfe, UK-SH, Campus Kiel, Arnold-Heller-Straße 3 (Haus 24), 24105 Kiel, GermanyIvo Leuschner, Institute of Pathology, University Hospitals Schleswig-Holstein Campus Kiel, Kiel, GermanyFelix Hilpert, Klinik für Gynäkologie und Geburtshilfe, UK-SH, Campus Kiel, Arnold-Heller-Straße 3 (Haus 24), 24105 Kiel, GermanyCaro...

Avoiding Mastectomy: Accelerated Partial Breast Irradiation for Breast Cancer Patients with Pacemakers or Defibrillators

Annals of Surgical Oncology — Tue, 24 May 2011 05:50:56 +0100

Conclusions APBI in patients with pacemakers or AICDs who desire breast preservation seems to be a technically safe and reasonable application of targeted radiation therapy. Content Type Journal ArticlePages 1-6DOI 10.1245/s10434-011-1784-2Authors Randal Croshaw, Department of Human Oncology, Division of Surgical Breast Oncology, Allegheny General Hospital, Pittsburgh, PA, USAYongbok Kim, Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA, USAErik Lappinen, Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA, USAThomas Julian, Department of Human Oncology, Division of Surgical Breast Oncology, Allegheny General Hospital, Pittsburgh, PA, USAMark Trombetta, Department of Radiation Oncology, Allegheny General Hospital, ...

Long-Term Outcomes of Invasive Ipsilateral Breast Tumor Recurrences After Lumpectomy in NSABP B-17 and B-24 Randomized Clinical Trials for DCIS

Medscape Today Headlines — Mon, 23 May 2011 11:05:03 +0100

Breast conserving surgery for DCIS may be more effective when combined with adjuvant therapies. Journal of the National Cancer Institute (Source: Medscape Today Headlines)

Locoregional Treatment for Breast Carcinoma After Hodgkin's Lymphoma: The Breast Conservation Option

International Journal of Radiation Oncology * Biology * Physics — Mon, 23 May 2011 04:00:00 +0100

Conclusions: Breast-conserving treatment can be an option for BCs that occur after HL, despite prior thoracic irradiation. It should consist of lumpectomy and adjuvant breast radiotherapy with use of adequate techniques, such as the lateral decubitus isocentric position, to protect the underlying heart and lung. (Source: International Journal of Radiation Oncology * Biology * Physics)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Early-Stage Young Breast Cancer Patients: Impact of Local Treatment on Survival

International Journal of Radiation Oncology * Biology * Physics — Fri, 20 May 2011 04:00:00 +0100

Purpose: In young women, breast-conserving therapy (BCT), i.e., lumpectomy followed by radiotherapy, has been associated with an increased risk of local recurrence. Still, there is insufficient evidence that BCT impairs survival. The aim of our study was to compare the effect of BCT with mastectomy on overall survival (OS) in young women with early-stage breast cancer.Methods and Materials: From two Dutch regional population-based cancer registries (covering 6.2 million inhabitants) 1,453 women (Source: International Journal of Radiation Oncology * Biology * Physics)

Basal Subtype of Invasive Breast Cancer Is Associated With a Higher Risk of True Recurrence After Conventional Breast-Conserving Therapy

International Journal of Radiation Oncology * Biology * Physics — Fri, 20 May 2011 04:00:00 +0100

Conclusions: Basal and HER-2 subtypes are significantly associated with higher rates of TR among women with pT1–T2 IBC after BCT. Younger age predicts for both TR and ELR. Strategies to reduce TR in basal breast cancers, such as increased boost doses, concomitant radiation and chemotherapy, or targeted therapy agents, should be explored. (Source: International Journal of Radiation Oncology * Biology * Physics)

Microinvasive neuroendocrine carcinoma arising from a central papilloma of the breast

Journal of Clinical Pathology — Thu, 19 May 2011 23:00:00 +0100

Breast central papilloma is a benign papillary neoplasm usually arising in the subareolar region.1 Cancerous change in a central papilloma is exceptionally rare, and, to our knowledge, there are only a few reports describing this unique condition.2–4 In the WHO Classification of tumours of the breast published in 2003, neuroendocrine carcinoma (NEC) is classified as a special tumour entity representing only about 2–5% of invasive breast carcinomas.5 Herein, we describe the first case of an NEC arising from a central papilloma of the breast. The patient was a premenopausal Japanese woman, 43 years of age, with a clinical symptom of bloody nipple discharge from the left breast. Ultrasonography revealed a well-defined, localised solid mass in a dilated large duct immediately ...

Persistent, Intensely Painful Ulceration of the Contralateral Breast

Cancer Network — Mon, 16 May 2011 12:00:00 +0100

A 71-year-old woman was receiving a multi-agent chemotherapeutic regimen following a lumpectomy for breast cancer. After the second round of treatment, she presented for medical care due to persistent, intensely painful ulceration of the contralateral breast. The process depicted began as scattered erythematous papules which became coalescent, and then eroded over a seven-day period. (Source: Cancer Network)

2nd lumpectomy an option for recurrent breast cancer

AuntMinnie.com Headlines — Tue, 10 May 2011 21:54:54 +0100

Women who have recurring breast cancer after breast conservation surgery and (more) (Source: AuntMinnie.com Headlines)

Image guidance using 3D-ultrasound (3D-US) for daily positioning of lumpectomy cavity for boost irradiation

Radiation Oncology — Sun, 08 May 2011 23:00:00 +0100

Conclusion: The lumpectomy cavity can shift significantly during fractionated radiation therapy. 3DUS can be used to image the cavity and correct for interfractional motion. Further studies to better define the protocol for clinical application of IGRT in breast cancer is needed. (Source: Radiation Oncology)

Preoperative Chemotherapy for Operable Breast Cancer Improves Surgical Outcomes in the Community Hospital Setting.

The Oncologist — Sun, 08 May 2011 23:00:00 +0100

Conclusion. PC for operable breast cancer can significantly improve surgical outcomes in community-based practice. PMID: 21558133 [PubMed - as supplied by publisher] (Source: The Oncologist)

Increased Positive Margin Identification Leads To Reduction In Patients Indicated For Re-Excision In Landmark Lumpectomy Surgery Trial

Health News from Medical News Today — Sun, 01 May 2011 09:00:00 +0100

Dune Medical Devices, Inc. has announced that the landmark, 664-patient pivotal trial evaluating the MarginProbe™ System met its primary endpoints. The MarginProbe System provides surgeons with a real time, intraoperative technology to detect microscopically-positive margins on excised tissues. Top-line data from the study were presented at the 12th Annual Meeting of the American Society of Breast Surgeons (ASBS) in Washington, DC... (Source: Health News from Medical News Today)

Annual mammogram enough after lumpectomy

Health News - UPI.com — Sat, 30 Apr 2011 21:35:40 +0100

PHILADELPHIA, April 30 (UPI) -- After breast cancer patients have had breast conserving therapy an annual mammogram is sufficient follow-up, U.S. researchers say. (Source: Health News - UPI.com)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Interval Post-Treatment Mammogram Not Needed For Breast Cancer Patients

Health News from Medical News Today — Fri, 29 Apr 2011 14:00:00 +0100

In this study, researchers wanted to determine the clinical relevance and utility of an interval mammogram (IM) after BCT. BCT is when a patient is treated with a lumpectomy and radiation rather than a mastectomy for early-stage breast cancer... (Source: Health News from Medical News Today)

Dune Medical's MarginProbe demonstrates increased positive margin identification leading to reduction in patients indicated for re-excision in landmark lumpectomy surgery trial

EurekAlert! - Medicine and Health — Fri, 29 Apr 2011 04:00:00 +0100

(HealthStar PR) Dune Medical Devices, Inc. today announced that the landmark, 664-patient pivotal trial evaluating the MarginProbe System met its primary endpoints. The MarginProbe System provides surgeons with a real time, intraoperative technology to detect microscopically-positive margins on excised tissues. Top-line data from the study were presented at the 12th Annual Meeting of the American Society of Breast Surgeons in Washington, D.C. (Source: EurekAlert! - Medicine and Health)

Sentinel Node Biopsy Alone for Node-Positive Breast Cancer: 12-Year Experience at a Single Institution

Journal of the American College of Surgeons — Thu, 28 Apr 2011 23:00:00 +0100

Conclusions: Axillary recurrence is rare after SN biopsy alone. This might be related to favorable tumor and patient characteristics and frequent use of adjuvant therapy. (Source: Journal of the American College of Surgeons)

Moffitt Cancer Center First In Tampa Bay To Offer A Single-Dose Radiation Treatment Alternative To Women With Early Breast Cancer

Health News from Medical News Today — Wed, 27 Apr 2011 08:00:00 +0100

Moffitt Cancer Center is the first in the Tampa Bay area to acquire the INTRABEAM® System, a new radiation platform that is designed to replace as many as six-and-a-half weeks of routine radiation therapy with a single 20- to 30-minute targeted radiation treatment. This revolutionary system, which delivers a targeted, intraoperative radiation treatment directly to the tumor site after lumpectomy, was shown to be as effective as traditional radiation for certain women with early breast cancer... (Source: Health News from Medical News Today)

Painful, Hot Gluctuant Lump on Chin of Breast Cancer Patient

Cancer Network — Sat, 16 Apr 2011 14:30:01 +0100

What would be the most appropriate thing to do first? A 31-year-old woman has undergone a lumpectomy for a small, estrogen receptor–positive breast tumor. She is receiving chemotherapy prior to local radiation. She acutely develops a painful, hot fluctuant lump on her chin. (Source: Cancer Network)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Intraoperative Radiation Therapy Provides Alternative For Women With Early Stage Breast Cancer

Health News from Medical News Today — Wed, 13 Apr 2011 09:00:00 +0100

Northwestern Medicine physicians are currently utilizing a new treatment option for breast cancer that allows women to receive a full dose of radiation therapy during breast conserving surgery. Traditionally, women who opt to have a lumpectomy must first have surgery then undergo approximately six weeks of radiation. This schedule can be challenging for women who have busy schedules or do not have access to a center offering radiation therapy. In some cases, the demanding schedule causes women to not comply with the recommended course of treatment, increasing their risk for cancer recurrence... (Source: Health News from Medical News Today)

SAVI Breast Brachytherapy Safe For Women With Breast Implants, Study Says

Health News from Medical News Today — Wed, 13 Apr 2011 09:00:00 +0100

The SAVI® applicator for breast brachytherapy was used to safely deliver post-lumpectomy radiation therapy to a woman with breast implants, according to a newly published paper in a peer-reviewed journal. The case study showed that SAVI produced an "optimal" clinical outcome and "excellent cosmetic results that pleased the patient," wrote the authors. The study was conducted by researchers at the University of Texas M.D. Anderson Cancer Center (Houston, Tex.) and is published online in the journal Brachytherapy... (Source: Health News from Medical News Today)

Radiation at time of lumpectomy may offer faster, more precise treatment for breast cancer patients, experts say

ScienceDaily Headlines — Tue, 12 Apr 2011 16:13:13 +0100

Physicians are currently utilizing a new treatment option for breast cancer that allows women to receive a full dose of radiation therapy during breast conserving surgery. Traditionally, women who opt to have a lumpectomy must first have surgery then undergo approximately six weeks of radiation. This schedule can be challenging for women who have busy schedules or do not have access to a center offering radiation therapy. In some cases, the demanding schedule causes women to not comply with the recommended course of treatment, increasing their risk for cancer recurrence. (Source: ScienceDaily Headlines)

Radiation at time of lumpectomy may offer faster, more precise treatment for breast cancer patients

EurekAlert! - Medicine and Health — Tue, 12 Apr 2011 04:00:00 +0100

(Northwestern Memorial Hospital) Northwestern Medicine physicians are currently utilizing a new treatment option for breast cancer that allows women to receive a full dose of radiation therapy during breast conserving surgery. Traditionally, women who opt to have a lumpectomy must first have surgery then undergo approximately six weeks of radiation. This schedule can be challenging for women who have busy schedules or do not have access to a center offering radiation therapy. In some cases, the demanding schedule causes women to not comply with the recommended course of treatment, increasing their risk for cancer recurrence. (Source: EurekAlert! - Medicine and Health)

What Is the Target Volume for Preoperative Accelerated Partial Breast Irradiation (APBI)? In Regards to Nichols et al. (Int J Radiat Oncol Biol Phys 2010;77:197–202) and Palta et al. (Int J Radiat Oncol Biol Phys 2010, in Press)

International Journal of Radiation Oncology * Biology * Physics — Sat, 09 Apr 2011 21:30:41 +0100

To the Editor: Two recent studies have suggested preoperative accelerated partial breast irradiation (APBI) as an alternative to conventional, post-lumpectomy APBI . We commend the authors’ efforts in this potentially important area of research, and we hope the following comments regarding target definition will be considered in future studies. (Source: International Journal of Radiation Oncology * Biology * Physics)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Preoperative and intraoperative predictors of positive margins after breast-conserving surgery: a retrospective review.

Breast Cancer — Mon, 04 Apr 2011 23:00:00 +0100

CONCLUSIONS: In the era of preoperative diagnosis of breast cancer with core biopsy, several pre- and intraoperative predictors of positive margins are identified that can aid the surgeon in surgical planning. PMID: 21465227 [PubMed - as supplied by publisher] (Source: Breast Cancer)

Cavity margins examination in breast-conserving therapy

Diagnostic Histopathology — Fri, 25 Mar 2011 00:00:00 +0100

Abstract: There is a good consensus that the pathologic lumpectomy margin status is the most important factor to determine the risk of local recurrence of carcinoma after breast-conserving therapy. However, there is no consensus regarding the definition of a complete excision or an adequate margin and the reported rates of repeat surgery for positive margins range from 10 to 57%. Therefore, an alternative technique of margin evaluation, called cavity shaving or cavity margin shaving has been proposed and applied by some surgical teams in order to reduce the need for re-excisions and to detect multifocality. We aim to describe in this review how to handle, analyse and report breast lumpectomy specimens with associated cavity margins and to discuss the potential advantages and drawbacks of t...

Long-Term Data Show That DCIS Has Excellent Prognosis

Medscape ObGyn and Womens Health Headlines — Wed, 23 Mar 2011 19:51:18 +0100

At 15-year follow-up, mortality from breast cancer was less than 5%; lumpectomy plus radiation plus tamoxifen halved the incidence of invasive breast cancer, compared with lumpectomy alone. Medscape Medical News (Source: Medscape ObGyn and Womens Health Headlines)

Practical Use of the Extended No Action Level (eNAL) Correction Protocol for Breast Cancer Patients With Implanted Surgical Clips

International Journal of Radiation Oncology * Biology * Physics — Mon, 21 Mar 2011 04:00:00 +0100

Conclusions: Surgical clips can be safely used for high-accuracy position verification and correction. Given compensation for time trends in the clips’ COM throughout the treatment course, eNAL resulted in better setup accuracies for both tumor bed and whole breast than NAL. (Source: International Journal of Radiation Oncology * Biology * Physics)

Dose Dense and Concurrent Trastuzumab for Early Breast Cancer in the Elderly

Clinical Oncology — Mon, 21 Mar 2011 00:00:00 +0100

We report on a 70-year-old woman without prior cardiopulmonary disease who was admitted with progressive dyspnoea developing 4 days after the first doses of paclitaxel (175mg/m2) and trastuzumab (6mg/kg). She had received appropriate premedications and no immediate infusion reactions occurred. Two weeks earlier, she had finished dose dense AC for stage T1c N0M0, oestrogen receptor-positive, progesterone receptor-negative, HER-2-positive and grade 3/3 right breast invasive ductal carcinoma. About 6 months earlier, she had undergone a lumpectomy and a concurrent regimen (AC-TH-H) was selected. Her left ventricular ejection fraction (LVEF) was 70% before the initiation of chemotherapy. On physical examination, she was afebrile and hypoxic (80% on room air). There was jugular venous distension...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Chemo for Breast Cancer Threatens Fertility in Young Women

About.com Breast Cancer — Sun, 20 Mar 2011 00:00:00 +0100

Cathy was just 22 when she was diagnosed with invasive ductal carcinoma. To make things worse, it was a high-grade tumor and HER2 positive. With support from her mother and her boyfriend, Cathy took some heavy-duty chemo after her lumpectomy, then had radiation. She didn't lose her breast, but she did lose her hair. One of her chemo drugs, Taxotere, affected her female hormones, her menstrual cycle, and her fertility....Read Full Post (Source: About.com Breast Cancer)

Shortened Radiation Course Shown To Lessen Chance Of Recurrence Of Non-Invasive Breast Cancer

Health News from Medical News Today — Tue, 15 Mar 2011 07:00:00 +0100

Findings by a researcher at The Cancer Institute of New Jersey (CINJ) highlighting the benefit of a shortened radiation course for patients with the most common type of non-invasive breast cancer are part of a feature article in the journal Cancer due out tomorrow. Sharad Goyal, MD, assistant professor of radiation oncology at UMDNJ-Robert Wood Johnson Medical School, is the lead investigator on the research, which focuses on patients with ductal carcinoma in situ (DCIS) who have had a lumpectomy. CINJ is a Center of Excellence of UMDNJ-Robert Wood Johnson Medical School... (Source: Health News from Medical News Today)

Long-Term Outcomes of Invasive Ipsilateral Breast Tumor Recurrences After Lumpectomy in NSABP B-17 and B-24 Randomized Clinical Trials for DCIS

JNCI — Tue, 15 Mar 2011 00:00:00 +0100

Conclusions Although I-IBTR increased the risk for breast cancer–related death, radiation therapy and tamoxifen reduced I-IBTR, and long-term prognosis remained excellent after breast-conserving surgery for DCIS. (Source: JNCI)

Increase in Mastectomies Performed in Patients in the Community Setting Undergoing MRI

The Breast Journal — Tue, 15 Mar 2011 00:00:00 +0100

This study is designed to determine whether the use of magnetic resonance imaging (MRI) leads to an increased number of unnecessary mastectomies in breast cancer patients in the community setting. This is a retrospective study of the records of 178 patients from the local offices of three community physicians. The medical records of patients over the age of 18 with breast cancer who underwent both MRI and mammogram imaging were reviewed. MRI detected more lesions than mammogram; however, these lesions were not cancerous. The lesions detected by mammogram correlated more with pathologic lesions. Of the 59 patients who underwent mastectomies, 78% had MRI and 22% did not have the imaging. Of the 100 patients who had both MRI and mammogram, 48% underwent lumpectomy and 46% had mastectomy. More...

Tamoxifen Plus Radiation With DCIS Lumpectomy Lowers Cancer Recurrence Risk

Health News from Medical News Today — Mon, 14 Mar 2011 20:00:00 +0100

For women with ductal carcinoma in situ (DCIS), adding radiation therapy and/or tamoxifen to treatment lowers the risk of the recurrence of aggressive cancer, doctors at Allegheny General Hospital and the National Surgical Adjuvant Breast Bowel Project revealed in the Journal of the National Cancer Institute. DCIS is the most common form of breast cancer. Head researcher, Thomas Julian, MD, said: "Women with DCIS can be reassured that they are not being overtreated when their doctor prescribes radiation therapy in addition to a lumpectomy... (Source: Health News from Medical News Today)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

DCIS Patients Who Get Invasive Breast Cancer Have Higher Mortality

Health News from Medical News Today — Fri, 11 Mar 2011 21:00:00 +0100

Women with ductal carcinoma in situ - DCIS - who later develop invasive breast cancer in the same breast are at higher risk of dying from breast cancer than those who do not develop invasive disease, according to a study published online March 11 in the Journal of the National Cancer Institute. Retrospective studies of women with DCIS have compared breast conserving surgery (lumpectomy) to mastectomy and found that survival rates are similar... (Source: Health News from Medical News Today)

JNCI: Radiotherapy + tamoxifen cuts invasive breast cancer recurrence in half

Health Imaging News — Fri, 11 Mar 2011 14:42:57 +0100

Across a 15 year study of more than 2,600 women who underwent lumpectomies for breast cancer, radiation therapy cut the likelihood of invasive ipsilateral breast tumor recurrence (I-IBTR) in half, while taking tamoxifen reduced I-IBTR by an additional 32 percent, according to a study published March 16 in the Journal of the National Cancer Institute. (Source: Health Imaging News)

Lymphoscintigraphy in breast cancer patients after neoadjuvant chemotherapy. Diagnostic value and the work-up of sentinel node negative patients.

Nuklearmedizin — Tue, 08 Mar 2011 16:00:09 +0100

Conclusion: On the basis of our findings, SLNB can not yet be recommended as a reliable staging method in breast cancer patients undergoing neoadjuvant chemotherapy. Patients with clinically positive axillary lymph nodes have a higher chance of unsuccessful lymphatic mapping by lymphoscintigraphy. Performing SLNB before NCTX in clinically node-negative patients may identify the subset of patients in whom axillary lymph node dissection can be omitted. Post NCTX axillary ultrasonography and 18F-FDG-PET/CT can not be suggested as valid axillary staging methods in case of a failed lymphatic mapping. PMID: 21336417 [PubMed - in process] (Source: Nuklearmedizin)

Accelerated partial breast irradiation using external beam conformal radiation therapy: A review

Critical Reviews in Oncology Hematology — Mon, 07 Mar 2011 05:00:00 +0100

Abstract: Lumpectomy followed by whole breast radiation therapy (i.e. breast conservation therapy (BCT)) is the standard of care for management of early stage breast cancer. However, its utilization has not been maximized because of a number of reasons including the logistic issues associated with the 5–6weeks of radiation treatment. Also, pathological and clinical data suggest that most ipsilateral breast cancer recurrences are in the vicinity of the lumpectomy. Accelerated partial breast irradiation (APBI) is an approach that treats only the lumpectomy bed plus a 1–2cm margin, rather than the whole breast with higher doses of radiation in a shorter period of time. There has been growing interest for APBI and various approaches have been developed and are under phase I–III clinical ...

MedWorm Sponsor Message: Find the best January Sales in the UK.

Surgical perspectives from a prospective, nonrandomized, multicenter study of breast conserving surgery and adjuvant electronic brachytherapy for the treatment of breast cancer

World Journal of Surgical Oncology — Mon, 07 Mar 2011 00:00:00 +0100

Conclusions: Early stage breast cancer can be treated with breast conserving surgery and APBI using electronic brachytherapy. Treatment was well tolerated, and these early outcomes were similar to the early outcomes with iridium-based balloon brachytherapy. (Source: World Journal of Surgical Oncology)

Is α/β for breast cancer really low?

Radiotherapy and Oncology — Wed, 02 Mar 2011 00:00:00 +0100

Conclusions: The analysis of the available clinical data from multiple institutions support that breast cancer has a low ratio of α/β, encouraging hypofractionated radiotherapy regimens for breast cancer. (Source: Radiotherapy and Oncology)

Whole Breast Radiation

About.com Breast Cancer — Mon, 28 Feb 2011 00:00:00 +0100

Whole breast radiation (WBI) is the most common type of external beam treatment for breast cancer. Whole breast radiation helps prevent recurrence or treat existing breast tumors. You may need whole breast radiation after a lumpectomy or mastectomy. Learn more about whole breast radiation here. (Source: About.com Breast Cancer)

Partial breast irradiation in a patient with bilateral breast cancers and CREST syndrome

Brachytherapy — Fri, 25 Feb 2011 05:00:00 +0100

Conclusions: Accelerated PBI was delivered safely to a patient with collagen vascular disease. By decreasing the surface area receiving radiation with accelerated PBI, we believe that the toxicity associated with the treatment was minimized. Future studies will be necessary to clarify the use of PBI in patients with collagen vascular disease. (Source: Brachytherapy)

Extent of surgery in the management of phyllodes tumor of the breast: A retrospective multicenter study from India

Journal of Cancer Research and Therapeutics — Thu, 24 Feb 2011 00:00:00 +0100

Conclusion: The unpredictable behavior of histological types and the disputable results of particular surgical procedures have contributed to the controversies. The therapeutic issue is further compounded by an imprecise preoperative diagnosis. This study shows that wide local excision for benign and borderline and simple mastectomy with or without reconstruction for the malignant PT of the breast are acceptable best surgical options. (Source: Journal of Cancer Research and Therapeutics)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Accelerated partial breast irradiation

Journal of Surgical Oncology — Tue, 22 Feb 2011 15:27:29 +0100

AbstractWhole breast irradiation (WBI) is the standard after breast conservation surgery. However, WBI in selected patients has been questioned. Accelerated partial breast irradiation (APBI) focuses treatment on the lumpectomy bed. Many modalities of delivering APBI have been developed: multicatheter interstitial brachytherapy, MammoSite balloon catheter, single insertion multicatheter devices, three‐dimensional conformal external‐beam radiation therapy and intraoperative techniques. Numerous studies of APBI have demonstrated excellent local control and cosmetic outcomes in early‐stage breast cancer patients. J. Surg. Oncol. 2011; 103:362–368. © 2011 Wiley‐Liss, Inc. (Source: Journal of Surgical Oncology)

Breast cancer occurred after Hodgkin's disease: Clinico-pathological features, treatments and outcome: Analysis of 214 cases

Critical Reviews in Oncology Hematology — Fri, 18 Feb 2011 05:00:00 +0100

Abstract: Background: Secondary tumours (ST) represent a major concern in survivors of Hodgkin's disease (HD). Breast cancer (BC) is the most frequent ST among young treated women.Material and methods: One hundred and eighty-nine women treated for HD by radiotherapy (RT) and/or chemotherapy (CT) subsequently developed 214 BCs.Results: Median age at HD diagnosis was 25 years (34% were less than 20). Median interval between HD and BC was 18.6 years, with a 42-year median age at first BC. According to the TNM classification, there were 30 (14%) T0 (non palbable lesions), 86 (40%) T1, 56 (26%) T2, 13 (6%) T3T4 and 29 (14%) Tx. There were 25 (13.2%) contralateral BC. 160 (75%) and 15 (7%) tumours were infiltrating ductal and lobular carcinomas, 7 (3.3%) were other subtypes and 27 (22%) DCIS.The...

Robotic radiosurgery expanded to breast cancer

Health Imaging News — Wed, 16 Feb 2011 10:23:38 +0100

The University of Texas Southwestern Medical Center has completed the first of 45 planned post-lumpectomy high-beam radiation treatments as part of a clinical trial to assess the effectiveness of the focused, shorter-course treatment. (Source: Health Imaging News)

UT Southwestern Launches Clinical Trial For Treatment Of Breast Cancer Using Robotic Cyberknife Technology

Health News from Medical News Today — Wed, 16 Feb 2011 08:00:00 +0100

Breast-cancer patient Kristin Wiginton is the first to be treated at UT Southwestern Medical Center with high-beam radiation using the Accuray CyberKnife System, which offers improved cosmetic results, less radiation exposure to surrounding tissue and a shorter treatment period. Dr. Wiginton is among 45 participants in a UT Southwestern-based clinical trial - the first of its kind in the Southwest - investigating use of the radiation delivery system for breast cancer. Her post-lumpectomy therapy lasted one-third the duration of a typical radiation session for a breast-cancer patient... (Source: Health News from Medical News Today)

Interest in cavity shaving in breast conservative treatment does not depend on lumpectomy technique

The Breast — Wed, 16 Feb 2011 00:00:00 +0100

In this study one hundred patients undergoing BCS with systematic cavity shaving were included. Margins less than 3 mm were considered to be insufficient. We tested clinico-pathological characteristics in order to identify predictive model of cavity margin shaving utility and we sought to determine if cavity margin shaving usefulness depends on volumes of resection. We showed that cavity shaving avoids the need for re-excision in 24% of cases as well as diagnosis of multifocality in 6% of cases. However, the clinical usefulness of cavity shaving was not related to the volumes of resection. (Source: The Breast)

MedWorm Sponsor Message: Find the best January Sales in the UK.

Interest in cavity shaving in breast conservative treatment does not depend on lumpectomy technique.

Breast — Mon, 14 Feb 2011 00:00:00 +0100

Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer

Cancer — Fri, 11 Feb 2011 00:00:00 +0100

CONCLUSIONS:Evidence was provided for an association of LAMP3 with tumor cell hypoxia in breast cancer xenografts. In the current breast cancer cohorts, LAMP3 had independent prognostic value. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)

Breast Conserving Therapy with Accelerated Partial Breast versus External Beam Whole Breast Irradiation: Comparison of Imaging Sequela and Complications in a Matched Population

The Breast Journal — Thu, 10 Feb 2011 00:00:00 +0100

Abstract: Our purpose was to evaluate and compare the imaging sequela and complications of accelerated partial breast irradiation (APBI) with those occurring in patients treated with standard external beam therapy. Patient selection included those who met the criteria for possible ABPI: age 45 or older; cancer stage T1N0M0 or ductal carcinoma in situ 3 cm or less, and negative surgical margins. One hundred and ninety seven had complete records and films available for review. Ninety‐seven (49%) were treated with APBI (MammoSite) and 100(51%) were treated with external beam. Image findings for APBI versus external beam were: distortion 90(93%) versus 83(83%), seroma 67(69%) versus 7(7%), skin edema 52(54%) versus 47(47%), increased stroma 75(77%) versus 66(66%), calcifications 10(10%)...

JAMA: Less surgery, more radiation & chemo improves breast cancer survival

Health Imaging News — Wed, 09 Feb 2011 07:23:54 +0100

Among patients with early-stage breast cancer that had spread to a nearby lymph node and who received treatment that included lumpectomy and radiation therapy, women who just had the sentinel lymph node removed (the first lymph node to which cancer is likely to spread from primary tumor) did not have worse survival than women who had more extensive axillary lymph node dissection, according to a study in the Feb. 9 issue of Journal of the American Medical Association. (Source: Health Imaging News)

Removing Many Lymph Nodes in Early Breast Cancer Not Always Needed: Study

Cancercompass News: Breast Cancer — Wed, 09 Feb 2011 00:00:00 +0100

With lumpectomy and radiation, only taking out one or two did not harm survival (Source: Cancercompass News: Breast Cancer)

MedWorm Sponsor Message: Please support the Doctors In Chains campaign for the medics tortured and sentenced for up to 15 years in Bahrain. #FreeDoctors

Breast cancer (non-metastatic)

Clinical Evidence — Tue, 08 Feb 2011 23:00:00 +0100

New evidence; conclusions changed for: Radiotherapy after breast-conserving surgery (for ductal carcinoma in situ) One systematic review added, which found that radiotherapy after breast-conserving surgery for ductal carcinoma in situ significantly reduced ipsilateral recurrence at up to 10.5 years of follow-up. Categorisation changed from Likely to be beneficial to Beneficial because of confirmation given in systematic review and maintenance of benefit with long-term follow-up. Adjuvant taxanes (for primary operable breast cancer) One systematic review and three subsequent RCTs added, which found that taxane-based therapies improved disease-free survival and overall survival compared with anthracycline-based regimens. Catego...

Removing Many Lymph Nodes in Early Breast Cancer Not Always Needed: Study

The Doctors Lounge - Oncology — Tue, 08 Feb 2011 22:00:00 +0100

With lumpectomy and radiation, only taking out one or two did not harm survival (Source: The Doctors Lounge - Oncology)

Removing Many Lymph Nodes in Early Breast Cancer Not Always Needed

MedlinePlus Health News — Tue, 08 Feb 2011 21:00:00 +0100

With lumpectomy and radiation, only taking out one or two did not harm survival Source: HealthDay Related MedlinePlus Pages: Breast Cancer, Mastectomy, Radiation Therapy (Source: MedlinePlus Health News)

Limited lymph node removal for certain breast cancer does not appear to result in poorer survival

ScienceDaily Headlines — Tue, 08 Feb 2011 05:00:00 +0100

Among patients with early-stage breast cancer that had spread to a nearby lymph node and who received treatment that included lumpectomy and radiation therapy, women who just had the sentinel lymph node removed (the first lymph node to which cancer is likely to spread from the primary tumor) did not have worse survival than women who had more extensive axillary lymph node dissection (surgery to remove lymph nodes found in the armpit), according to a new study. (Source: ScienceDaily Headlines)