MedWorm: Breast Needle Aspiration

New Weapon in Breast Cancer Battle

OrlandoSentinel: Medical Research — Thu, 18 Mar 2010 00:00:00 +0100

There's a potential new weapon in the battle against breast cancer. Researchers say super-cold gas can kill tumors, and make sure they never return. The way it works is, doctors inject through a needle the super-cold gas into a patient around the tumor.... (Source: OrlandoSentinel: Medical Research)

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The 'ice ball' therapy that wipes out breast cancer cells

the Mail online | Health — Wed, 17 Mar 2010 07:55:46 +0100

The technique called cryotherapy is already used to treat prostate cancer. It involves inserting several needle-like 'cryoprobes' into the tumour and passing super-cold gas through them. (Source: the Mail online | Health)

After axillary surgery for breast cancer – is it safe to take blood samples or give intravenous infusions?

Journal of Clinical Nursing — Tue, 16 Mar 2010 00:00:00 +0100

Conclusions. This study indicates that if a blood sample is taken or intravenous injection is given according to the current Swedish guidelines for health care professionals, there should be a very low risk of complications.Relevance to clinical practice. If intravenous procedures are performed without any disadvantage in the arm of the operated side in women who have undergone axillary surgery, the clinical problem of finding a proper vein and the psychological concern of the women can be reduced. (Source: Journal of Clinical Nursing)

Rosai-Dorfman disease confined to the breast

Annals of Diagnostic Pathology — Fri, 12 Mar 2010 15:10:37 +0100

We present the histopathologic findings and follow-up of each patient and conduct a literature review of mammary Rosai-Dorfman disease with emphasis on its differential diagnosis. Because Rosai-Dorfman disease frequently mimics invasive breast carcinoma in its clinical presentation and radiographic appearance—and can mimic other benign or malignant histiocytic lesions microscopically—awareness and appropriate diagnosis of this entity are essential for proper treatment. (Source: Annals of Diagnostic Pathology)

Are there racial/ethnic disparities among women younger than 40 undergoing mammography?

Breast Cancer Research and Treatment — Wed, 10 Mar 2010 13:17:12 +0100

This study of community-based practice found racial/ethnic variability in mammography indication, recommendations, and outcomes among women undergoing first mammography before 40. These findings highlight important areas for future research to understand the motivating factors for these practice patterns and the implications of early mammography use. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0812-4Authors Julie M. Kapp, University of Missouri Department of Family and Community Medicine MA306 Medical Sciences Bldg, 1 Hospital Drive Columbia MO 65212 USARod Walker, Group Health Research Institute Seattle WA USASebastien Haneuse, Group Health Research Institute Seattle WA USADiana S. M. Buist, Group Health Research Institute Seattle WA USABonnie C. Yank...

Initial axillary staging of breast cancer using ultrasound-guided fine needle aspiration: a liquid-based cytology study

Cytopathology — Wed, 10 Mar 2010 00:00:00 +0100

Conclusions: We advocate that US-guided fine needle aspiration (FNA) combined with liquid-based cytology of axillary lymph nodes should be included in the preoperative staging of breast cancer. (Source: Cytopathology)

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Aspiration of Breast Lumps Reviewed

Medscape Today Headlines — Tue, 09 Mar 2010 15:39:15 +0100

A review describes an "in office" approach for immediate evaluation of women who present to their family physician with a breast lump. Medscape Medical News (Source: Medscape Today Headlines)

Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins

Breast Cancer Research — Fri, 05 Mar 2010 00:00:00 +0100

Conclusions: High performing DDR focus formation resulted in tumor resistance to DNA damage-inducing chemotherapy. Our results suggested an importance of evaluation of DDR competence to predict breast cancer chemosensitivity, and merits further studying into its usefulness in exclusion of non-responder patients. (Source: Breast Cancer Research)

Neuroendocrine ductal carcinoma in situ of the breast: cytological features in 32 cases

Cytopathology — Fri, 05 Mar 2010 00:00:00 +0100

Conclusions: NE-DCIS has distinctive cytological features and can therefore be diagnosed as a neuroendocrine tumour in most FNAs and some nipple discharge smears by cytological examination employing immunohistochemical techniques. We emphasize that a breast lesion with these features may be in situ and not invasive, and also that there is a risk of under-diagnosis. (Source: Cytopathology)

Pilot study of radiofrequency ablation therapy without surgical excision for T1 breast cancer: evaluation with MRI and vacuum-assisted core needle biopsy and safety management.

Breast Cancer — Thu, 04 Mar 2010 00:00:00 +0100

CONCLUSIONS: RFA therapy appeared relevant and applicable for patients with small breast cancer. Because small skin burns were observed as adverse events, close attention should be paid in the course of the RFA procedure. PMID: 20204556 [PubMed - as supplied by publisher] (Source: Breast Cancer)

Rates of pathological underestimation for 9 and 12 gauge breast needle core biopsies at surgical excision.

Breast Cancer — Thu, 04 Mar 2010 00:00:00 +0100

CONCLUSION: In this analysis, the underestimation of needle biopsy results with surgical pathology was found to be 8.00% for the 12 gauge group and 8.24% for the 9 gauge group. These results support our current clinical practice of utilizing either needle gauge. PMID: 20204553 [PubMed - as supplied by publisher] (Source: Breast Cancer)

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Office management of a palpable breast lump with aspiration.

cmaj — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Heisey RE, McCready DR PMID: 20194561 [PubMed - as supplied by publisher] (Source: cmaj)

Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode

Breast Cancer Research and Treatment — Fri, 26 Feb 2010 16:44:08 +0100

Abstract Irreversible electroporation (IRE) is a therapeutic technology for the ablation of soft tissues using electrodes to deliver intense but short electric pulses across a cell membrane, creating nanopores that lead to cell death. This phenomenon only affects the cell membrane, leaving the extracellular matrix and sensitive structures intact, making it a promising technique for the treatment many types of tumors. In this paper, we present the first in vivo study to achieve tumor regression using a translatable, clinically relevant single needle electrode for treatment administration. Numerical models of the electric field distribution for the protocol used suggest that a 1000 V/cm field threshold is sufficient to treat a tumor, and that the electric field distribu...

Randomized, Blinded, Sham-Controlled Trial of Acupuncture for the Management of Aromatase Inhibitor-Associated Joint Symptoms in Women With Early-Stage Breast Cancer [Breast Cancer]

Journal of Clinical Oncology — Wed, 24 Feb 2010 23:01:02 +0100

Conclusion Women with AI-induced arthralgias treated with TA had significant improvement of joint pain and stiffness, which was not seen with SA. Acupuncture is an effective and well-tolerated strategy for managing this common treatment-related side effect. (Source: Journal of Clinical Oncology)

Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma

Diagnostic Cytopathology — Wed, 24 Feb 2010 00:00:00 +0100

We present a case of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver and a review of the literature. Diagn. Cytopathol. 2010. © 2010 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)

Role of sonoelastography in characterising breast nodules. Preliminary experience with 120 lesions

La Radiologia Medica — Tue, 23 Feb 2010 07:59:36 +0100

Conclusions The use of sonoelastography to complement mammography and ultrasonography could help in the differential diagnosis of nodular breast lesions, especially in Breast Imaging Reporting Data System (BI-RADS) 3 lesions with marked elasticity (S≤3). In these cases, the high concordance between elastography and cytology or histology in diagnosing benign lesions could reduce the number of needle biopsies and guide women at low radiological risk towards follow-up. Content Type Journal ArticleCategory Breast Radiology/SenologiaDOI 10.1007/s11547-010-0518-zAuthors E. Regini, Università di Torino, ASO San Giovanni Battista di Torino, Sede Molinette Istituto di Radiologia Diagnostica ed Interventistica Via Genova 3 10126 Torino ItalyS. Bagnera, Università di Tori...

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Axillary node staging by ultrasonography and fine-needle aspiration cytology in patients with breast cancer

British Journal of Surgery — Tue, 23 Feb 2010 00:00:00 +0100

This study evaluated the role of axillary ultrasonography (AUS) and fine-needle aspiration cytology (FNAC) in preoperative staging of the axilla in patients with invasive breast cancer.Between October 2006 and March 2009, 502 patients scheduled to undergo surgery for invasive breast cancer had preoperative AUS. All patients with suspicious nodes on ultrasonography underwent FNAC, and those with positive cytology proceeded directly to axillary node clearance. Patients with normal findings on AUS or negative cytology underwent sentinel node biopsy (SNB).A total of 137 (27·3 per cent) of 502 patients had axillary node metastases on final histology. Thirty-nine (28·5 per cent) node-positive patients were identified by AUS-FNAC and spared unnecessary SNB. AUS-FNAC had a sensitivity of 28·5 p...

Axillary node staging by ultrasonography and fine-needle aspiration cytology in patients with breast cancer.

The British Journal of Surgery — Tue, 23 Feb 2010 00:00:00 +0100

CONCLUSION:: Preoperative AUS-FNAC avoided unnecessary SNB in 28.5 per cent of node-positive patients and in 7.8 per cent of patients overall. Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 20186888 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)

Axillary Lymph Node Metastasis: CA-15-3 and Carcinoembryonic Antigen Concentrations in Fine-Needle Aspirates for Preoperative Diagnosis in Patients with Breast Cancer [BREAST IMAGING]

Radiology — Mon, 22 Feb 2010 20:50:30 +0100

The mean fine-needle aspiration (FNA) concentrations of carcinoembryonic antigen (CEA) and the breast cancer antigen CA-15-3 in metastatic axillary lymph nodes (ALNs) were higher (both P = .02) than those in nonmetastatic ALNs, and the sensitivity of FNA cytology combined with FNA concentrations of CA-15-3 and CEA was higher (P = .01) than that of FNA cytology alone. (Source: Radiology)

Breast pathology

Surgery (Medicine Publishing) — Mon, 22 Feb 2010 16:03:43 +0100

Abstract: Cellular pathology is a key component of the breast disease multidisciplinary team, representing the ‘gold standard’ in the diagnosis of breast cancer and providing information key to the determination of prognosis and management. Material may be obtained for pathological examination using fine needle aspiration (cytology) or core biopsy and surgical excision (histopathology). Common benign conditions include fibrocystic change, fibroadenomas, intraduct papillomas and radial scars. Carcinoma is by far the most common malignant tumour and may exist in in situ or invasive forms. The NHS Breast Screening Programme has resulted in the detection of less advanced breast cancers, for example in situ carcinoma and small, low-grade invasive carcinomas. A cellular pathology report for ...

AIM: Core-needle biopsy nearly as accurate, safer than surgical biopsy for breast cancer

Health Imaging News — Wed, 17 Feb 2010 13:01:46 +0100

Stereotactic- and ultrasonography-guided core-needle biopsy procedures may be considered to be nearly as accurate as open surgical biopsy, with lower complication rates for average-risk women suspected of having breast cancer, said the results of a review published in the Feb. 16 issue of Annals of Internal Medicine. (Source: Health Imaging News)

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AIM: Core-needle biopsy nearly as accurate, safer than surgical biopsy for breast cancer

Health Imaging News — Wed, 17 Feb 2010 13:01:46 +0100

Feasibility study on the treatment of small breast carcinoma using percutaneous US-guided preferential radiofrequency ablation (PRFA).

Breast — Tue, 16 Feb 2010 00:00:00 +0100

Authors: Wiksell H, Löfgren L, Schässburger KU, Grundström H, Janicijevic M, Lagerstedt U, Leifland K, Nybom R, Rotstein S, Saracco A, Schultz I, Thorneman K, Wadström C, Westman L, Wigzell H, Wilczek B, Auer G, Sandstedt B The purpose of this study was to determine the safety and efficacy of percutaneous ultrasound (US) guided preferential radiofrequency ablation (PRFA) of unifocal human invasive breast carcinoma with largest radiological diameters of up to 16 mm. Thirty-three patients were enrolled in a study to be treated prior to scheduled partial mastectomy. A needle-shaped treatment electrode, successively developed in two different sizes, was placed into the center of the lesions using ultrasound guidance. A temperature of 85 degrees C was maintained for 10 m...

Injection of absolute alcohol into cysts cavities, after cyst aspiration, for treating and reducing the rate of recurrence of benign breast cysts

Gynecological Surgery — Sat, 13 Feb 2010 06:48:24 +0100

Abstract The purpose of this study is to determine whether injection of absolute alcohol into cysts cavities, after cyst aspiration, is useful to treat benign breast cysts (BBCs) and to reduce its rate of recurrence. Fifteen women with recurrent BBC were enrolled in a 3.5 years follow-up study. Cyst aspiration and replacement by an equal volume of absolute alcohol (99%) within cysts cavities was performed under guidance of ultrasonography. BBC was defined as a breast cyst without cytologic changes for malignancy. Ultrasonographic breast images and breast biopsies were performed to verify cyst resolution and recurrence. Breast cysts completely disappeared in six (40%) women and significantly decreased its average size (67 ± 38 to 5.2 ± 6.8 mm, p = 0....

Reoperation Rate For Breast Cancer: Addition Of MRI To Conventional Assessment Has No Effect (COMICE Study)

Health News from Medical News Today — Fri, 12 Feb 2010 08:00:00 +0100

An article published in this week's edition of The Lancet reports that addition of magnetic resonance imaging (MRI) scans to conventional triple assessment techniques for diagnosis of breast cancer has no effect on the reoperation rate. Triple assessment is the combination of three modes of assessment: clinical examination, imaging of the breast (by X-ray mammography and/or ultrasound), and pathological assessment of the "lump" (by either fine needle aspiration cytology or core biopsy)... (Source: Health News from Medical News Today)

Addition Of MRI To Conventional Assessment Has No Effect On Breast Cancer Re-Operation Rate

Health News from Medical News Today — Fri, 12 Feb 2010 08:00:00 +0100

An article published in this week's edition of The Lancet reports that addition of magnetic resonance imaging (MRI) scans to conventional triple assessment techniques for diagnosis of breast cancer has no effect on the re-operation rate. Triple assessment is the combination of three modes of assessment: clinical examination, imaging of the breast (by X-ray mammography and/or ultrasound), and pathological assessment of the "lump" (by either fine needle aspiration cytology or core biopsy)... (Source: Health News from Medical News Today)

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Can Breast MRI Predict Axillary Lymph Node Metastasis in Women Undergoing Neoadjuvant Chemotherapy

Annals of Surgical Oncology — Mon, 08 Feb 2010 17:20:08 +0100

Conclusion Breast MRI has moderate sensitivity and high specificity for predicting axillary lymph node status prior to NAC. In patients found to be node positive prior to NAC, MRI was able to predict with moderate sensitivity and specificity whether residual nodal disease was present. The accuracy of MRI is not adequate to obviate either the need for staging by sentinel node biopsy or the need for completion axillary dissection in women determined to be node positive prior to NAC. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-010-0934-2Authors Sara Javid, Brigham and Women’s Hospital and Dana Farber Cancer Institute, Harvard Medical School Department of Surgery Boston USADavendra Segara, Brigham and Women’s Hospital and Dana Farber Cancer...

Fine-needle aspiration cytology as the first pathological diagnostic modality in breast lesions: A comparison with core needle biopsy

Basic and Applied Pathology — Fri, 05 Feb 2010 00:00:00 +0100

Conclusions: Our data suggest that FNAC is an accurate and reliable first line diagnostic tool for evaluation of breast lesions when compared with core biopsy. (Source: Basic and Applied Pathology)

Feasibility of FDG PET/CT to monitor the response of axillary lymph node metastases to neoadjuvant chemotherapy in breast cancer patients

European Journal of Nuclear Medicine and Molecular Imaging — Wed, 03 Feb 2010 17:54:56 +0100

Conclusion The high accuracy in visualizing lymph node metastases and the sufficiently high SUVmax and tumour to background ratio at baseline suggest that it is feasible to monitor the axillary response with FDG PET/CT, especially in triple-negative tumours. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1343-2Authors Marieke E. Straver, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital Department of Surgical Oncology Plesmanlaan 121 1066 CX Amsterdam The NetherlandsTjeerd S. Aukema, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital Department of Nuclear Medicine Plesmanlaan 121 1066 CX Amsterdam The NetherlandsRenato A. Valdes Olmos, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital Depart...

Criteria for the safe avoidance of needle sampling in young women with solid breast masses

Clinical Radiology — Wed, 03 Feb 2010 15:36:28 +0100

Conclusion: Application of the proposed criteria would spare a significant number of young women unnecessary needle sampling. (Source: Clinical Radiology)

Ductal Carcinoma In Situ of the Breast: A Systematic Review of Incidence, Treatment, and Outcomes

JNCI — Tue, 02 Feb 2010 21:01:32 +0100

Conclusions Scientific questions deserving further investigation include the relationship between mammography use and DCIS incidence and whether imaging technologies and treatment guidelines can be modified to focus on lesions that are most likely to become clinically problematic. (Source: JNCI)

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Cost Modeling of Preoperative Axillary Ultrasound and Fine-Needle Aspiration to Guide Surgery for Invasive Breast Cancer

Annals of Surgical Oncology — Tue, 02 Feb 2010 07:00:06 +0100

Conclusions The additional cost of performing axillary US with possible FNA in every patient is balanced, on average, by the savings from avoiding SLN in cases where metastasis can be documented preoperatively. Routine use of preoperative axillary US with FNA to guide surgical planning can decrease the overall cost of patient care for invasive breast cancer. Content Type Journal ArticleCategory Healthcare Policy and OutcomesDOI 10.1245/s10434-010-0919-1Authors Judy C. Boughey, Mayo Clinic Department of Surgery Rochester Minnesota USAJames P. Moriarty, Mayo Clinic Department of Health Sciences Rochester Minnesota USAAmy C. Degnim, Mayo Clinic Department of Surgery Rochester Minnesota USAMelissa S. Gregg, Mayo Clinic Department of Health Sciences Rochester Minnesota USA...

Axillary Lymph Node Metastasis: CA-15-3 and Carcinoembryonic Antigen Concentrations in Fine-Needle Aspirates for Preoperative Diagnosis in Patients with Breast Cancer [BREAST IMAGING]

Continuous Publishing articles — Mon, 01 Feb 2010 14:54:30 +0100

Clinicopathologic factors associated with involved margins after breast-conserving surgery for invasive lobular carcinoma.

Clinical Genitourinary Cancer — Mon, 01 Feb 2010 00:00:00 +0100

Conclusion: Core needle biopsy is the preferred method of diagnostic biopsy before surgical intervention. With appropriate patient selection, most patients with early-stage ILC can undergo successful BCS. PMID: 20133259 [PubMed - in process] (Source: Clinical Genitourinary Cancer)

Overview of the role of pre-operative breast MRI in the absence of evidence on patient outcomes

The Breast — Mon, 01 Feb 2010 00:00:00 +0100

Abstract: The role of pre-operative breast MRI is outlined on the basis of the existing evidence in favor of a superior capability in comparison with mammography and sonography to detect ipsilateral and contralateral malignant lesions and to evaluate the disease extent, including the extensive intraductal component associated with invasive cancers. Patients with a potential higher anticipated benefit from pre-operative MRI can be identified as those: with mammographically dense breasts; with a unilateral multifocal/multicentric cancer or a synchronous bilateral cancer already diagnosed at mammography and sonography; with a lobular invasive cancer; at high-risk for breast cancer; with a cancer which shows a discrepancy in size of >1 cm between mammography and sonography; or under considerat...

Minimally Invasive Staging of the Axilla in Breast Cancer: A Pilot Study to Assess the Feasibility of Real-Time RT-PCR, Axillary Ultrasound, and Fine Needle Aspiration Biopsy

Journal of Surgical Research — Mon, 25 Jan 2010 16:39:42 +0100

Introduction: We sought to establish the clinical relevance of metastatic disease in the axillary lymph nodes of patients with clinically node-negative breast cancer, as detected by axillary ultrasound (AUS), fine needle aspiration biopsy (FNAB), and real-time reverse transcription polymerase chain reaction (RT-PCR). Methods: Eighty patients with clinically node-negative breast cancer were enrolled in a prospective study. Patients underwent AUS to evaluate lymph node morphology as either “normal” or “suspicious” by standard criteria (generalized or focal thickening of the cortex, disparity in size of one or more lymph nodes compared with others, rounded appearance, and effacement of the lymph node fatty hilum). Patients with “normal” AUS underwent sentinel lymph node biopsy (SL...

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Histology after lumpectomy in women with epithelial atypia on stereotactic vacuum-assisted breast biopsy

European Journal of Surgical Oncology — Fri, 22 Jan 2010 13:47:57 +0100

Conclusion: ADH diagnosed by vacuum-assisted breast biopsy frequently corresponds to cancer on open surgical biopsy. Surgical excision of all breast lesions containing atypical hyperplasia on percutaneous biopsy can be recommended. (Source: European Journal of Surgical Oncology)

Cysticercosis of the Breast

Journal of Diagnostic Medical Sonography — Fri, 22 Jan 2010 00:29:35 +0100

This article reports a case from India, where a young woman presented with a firm, nontender breast lump. Breast sonography imaging with a high-frequency transducer revealed a well-defined cystic lesion with an internal echogenic nodule and surrounding hypoechoic area. Subsequently, fine-needle aspiration cytology was performed, which confirmed the diagnosis of cysticercosis. (Source: Journal of Diagnostic Medical Sonography)

Factors That Impact the Duration of MRI-Guided Core Needle Biopsy

American Journal of Roentgenology — Thu, 21 Jan 2010 20:14:22 +0100

CONCLUSION. Variables that minimized procedure duration were number of image acquisitions, number of patient insertions or removals from the magnet, and assistance of a breast imaging fellow-in-training. No patient-related or target-related variables impacted procedure time. (Source: American Journal of Roentgenology)

Role of fine needle aspiration cytology in diagnosis of filarial infestation

Diagnostic Cytopathology — Wed, 20 Jan 2010 00:00:00 +0100

Filariasis is a tropical disease transmitted by the Culex mosquitoes. The diagnosis of it is conventionally made by demonstrating microfilariae in the peripheral blood smear. However; microfilariae and adult filarial worm have been incidentally detected in fine needle aspirates of various lesions in clinically unsuspected cases. The cases of filariasis diagnosed by fine needle aspiration cytology (FNAC) were retrieved from the archives of the Cytopathology laboratory between the periods of January 1998 to February 2009. Both Papanicolaou- and May-Grunwald-Giemsa-stained smears were available in all the cases. A total of 26 diagnosed cases of filariasis were found, of which 19 were related to funiculo-epididymitis, four presented with breast lump, and three cases with lymphadenopathy. Smear...

The use of fine-needle aspiration biopsy samples for the assessment of basal phenotype in triple negative breast cancer patients: A correlative study

Diagnostic Cytopathology — Wed, 20 Jan 2010 00:00:00 +0100

This study was designed to correlate FNAB samples with corresponding surgical specimens for the assessment of basal phenotype in patients with triple negative breast cancer (TNBC). A total of 198 cases of TNBC with matching FNAB and surgical specimens were identified. Forty-six cases with sufficient tissue in both FNAB cell blocks and surgical specimens were selected. Tissue microarray blocks were prepared and stained with six biomarkers (CK5/6, p63, SMA, EGFR, C-Kit, and p53). For statistical analysis, we used the observed (Gross) percentage of agreement and also calculated the Cohen's Kappa for each biomarker. We found a high agreement between the two groups as shown by the values of Observed (Gross) percentage of agreement (mostly 90% or higher except for the C-Kit which was 78%). In ad...

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Breast cancer screening

NHS News Feed — Tue, 19 Jan 2010 19:25:00 +0100

Conclusion This review presents its authors’ opinions on the 2008 review of the NHS Breast Cancer Screening Programme. They support some areas of their discussion using the findings of other research and statistics from national databases. They conclude that undue emphasis has been placed on the benefits of breast screening, and not enough on its harms. The balance of benefits and harms is an important consideration for any screening programme. But the complexity of the evidence means that this balance can be difficult to judge, and different people may interpret the evidence in different ways. None of the groups involved would deny that screening can have harms, but the precise balance of benefits and harms of breast screening is a controversial issue. The complexity of the issues ...

Merkel cell carcinoma metastatic to the thyroid gland: Aspiration findings and differential diagnosis

Diagnostic Cytopathology — Sat, 16 Jan 2010 00:00:00 +0100

Clinically diagnosed metastasis to the thyroid gland is exceptionally rare and may present diagnostic issues on fine needle aspiration. The most common primary sites of metastases to the thyroid are cancers of the lung, breast, skin (especially melanoma), colon, and kidney. Herein, we report a case of metastatic Merkel cell carcinoma to the thyroid presenting as a 2.1-cm solid nodule in a 50-year-old male with a previous history of Merkel cell carcinoma of the upper extremity. The aspirates were moderately to highly cellular featuring small to intermediate sized cells with scant to no cytoplasm, round-to-oval nuclei with finely dispersed chromatin, and predominantly arranged as scattered single cells. There was focal nuclear molding, numerous mitoses, and karyorrhectic nuclei. The differen...

Axillary staging prior to or after neoadjuvant systemic therapy? A single institutional experience

Journal of Surgical Oncology — Fri, 15 Jan 2010 00:00:00 +0100

The study aim was to investigate our institutional strategies for axillary staging in breast cancer patients undergoing neoadjuvant therapy.We identified 595 patients treated with neoadjuvant therapy between 2000 and 2007. Axillary staging occurred by four methods: (1) pre-therapy fine needle aspiration biopsy (FNAB); (2) pre-therapy sentinel lymph node biopsy (SLNB); (3) post-therapy SLNB; or (4) post-therapy axillary lymph node dissection (ALND).Of 595 patients, 115 underwent FNAB (Group 1; 36 N0, 79 N+), 88 underwent SLNB pre-therapy (Group 2; 47 N0, 41 N+), 55 underwent SLNB post-therapy (Group 3; 42 N0, 13 N+), and 337 underwent ALND post-therapy (Group 4; 133 N0, 204 N+). There was no difference between groups according to patient age, race, stage of disease, estrogen/progesterone re...

Predictors of invasion in needle core biopsies of the breast with ductal carcinoma in situ

Modern Pathology AOP — Fri, 15 Jan 2010 00:00:00 +0100

Authors: Edna May L Go, Siu-Ki Chan, Joaquim S L Vong, Philip C W Lui, Anthony W H Chan, Tony K F Ma, Mark A Ang, Bonita K B Law, Puay-Hoon Tan & Gary M Tse (Source: Modern Pathology AOP)

Radiofrequency ablation as local therapy for early breast carcinomas.

Breast Cancer — Thu, 14 Jan 2010 00:00:00 +0100

CONCLUSION: RF ablation is a safe and promising minimally invasive treatment for small breast carcinomas with pathological tumor size </=2 cm in diameter and without EIC. PMID: 20072824 [PubMed - as supplied by publisher] (Source: Breast Cancer)

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A case of tumor-forming pseudoangiomatous stromal hyperplasia of the breast.

Breast Cancer — Thu, 14 Jan 2010 00:00:00 +0100

Authors: Takagi H, Miyairi J, Hata M, Kirii Y, Tsuchiya S Pseudoangiomatous stromal hyperplasia (PASH), characterized by the presence of slit-like spaces embedded in a hyalinized stroma, is sometimes observed during pathologic examination of breast-tissue specimens. Because tumor-forming PASH is rare, we report a case of a 41-year-old woman admitted to our hospital with a tumor in her left breast. Ultrasonography and aspiration biopsy cytology revealed a benign tumor. After performing Mammotome((R)) biopsy, the lesion was diagnosed as PASH of the breast based on characteristic findings of histology and immunohistochemical studies. Because PASH tumors do not usually become malignant, we decided to perform ultrasonographic follow-up without tumor excision. PMID: 20072822 [PubMed - as...

Prospective Comparison of Clinical and Genomic Multivariate Predictors of Response to Neoadjuvant Chemotherapy in Breast Cancer.

Cell Research — Tue, 12 Jan 2010 00:00:00 +0100

CONCLUSIONS: Three conceptually different predictors performed similarly in this validation study and tended to identify the same patients as responders. A genomic predictor that relied solely on a composite of individual drug sensitivity predictions from cell lines did not show any predictive value. Clin Cancer Res; 16(2); 711-8. PMID: 20068086 [PubMed - as supplied by publisher] (Source: Cell Research)

Punch biopsy: A useful adjunct in a rapid diagnosis breast clinic.

Breast — Mon, 11 Jan 2010 00:00:00 +0100

CONCLUSION: PB is a valuable adjunct to conventional methods of tissue diagnosis such as CB and FNAC in both benign and malignant breast lesions. PMID: 20071172 [PubMed - as supplied by publisher] (Source: Breast)

Structured Ultrasonography Workshop for Breast Surgeons: Is It An Effective Training Tool?

World Journal of Surgery — Thu, 07 Jan 2010 16:12:23 +0100

Conclusions Structured workshops are effective for training surgeons in US application and USGBB and should be considered as part of standardized training guidelines and credentialing. Theory and practical components demonstrated similar efficacy and should be considered integral components in training programs. Formal training decreases complication rates, especially among the inexperienced. Content Type Journal ArticleDOI 10.1007/s00268-009-0342-6Authors Michael T. Law, Breast and Endocrine Surgery Unit, Princess Alexandra Hospital 199 Ipswich Road Buranda QLD 4102 AustraliaIan C. Bennett, Breast and Endocrine Surgery Unit, Princess Alexandra Hospital 199 Ipswich Road Buranda QLD 4102 Australia Journal World Journal of SurgeryOnline ISSN 1432-2323Print ISSN 0...

Breast cancer in women under 40years of age: A series of 57 cases from Northern Ireland.

Breast — Thu, 07 Jan 2010 00:00:00 +0100

CONCLUSION: Our study reports a low familial trait rate combined with a high proportion of hormonally active tumours less than grade III which suggests that breast cancer in this series of young women from Northern Ireland may be less aggressive and more hormonally responsive than anticipated. PMID: 20060718 [PubMed - as supplied by publisher] (Source: Breast)

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Genome architecture: Reliable repositioning in cancer

Nature Reviews Genetics — Wed, 06 Jan 2010 00:00:00 +0100

Nature Reviews Genetics 11, 92 (2010). doi:10.1038/nrg2742 Author: Chris Gunter One of the biggest challenges in cancer is proper diagnosis in the smallest possible amounts of tissue, such as that from a core needle biopsy in potential breast cancer cases. Routine protocols now in place generally rely on the opinion of a trained cytopathologist and (Source: Nature Reviews Genetics)

Should fine-needle aspiration cytology be the first choice diagnostic modality for assessment of all nonpalpable breast lesions? The experience of a breast cancer screening center in Alexandria, Egypt

Diagnostic Cytopathology — Mon, 04 Jan 2010 00:00:00 +0100

In conclusion, aiming to maximize the preoperative diagnosis of cancer, it would be cost efficient and time saving to use FNAC as a first-line investigation to benefit from the wealth of cytological information yielded, followed by CNB in selected cases. Diagn. Cytopathol. 2010. © 2010 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)

Reed-Sternberg cells in breast FNA of a patient with left breast mass

Diagnostic Cytopathology — Mon, 04 Jan 2010 00:00:00 +0100

We report a rare case of Hodgkin's lymphoma presented as a breast mass in a 23-year-old woman diagnosed on fine needle aspiration (FNA). At presentation, she had no B symptoms, or palpable lymphadenopathy. Diagn. Cytopathol. 2010. © 2010 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)

A simple aid to wire localisation procedure in breast surgery: 'covering the hook-wire with a needle'.

Annals of the Royal College of Surgeons of England — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Ray K, Chouhan A, Johri A PMID: 20063447 [PubMed - in process] (Source: Annals of the Royal College of Surgeons of England)

Multiple intraductal papillomas of breast clinically masquerading as malignancy.

Indian Journal of Pathology and Microbiology — Fri, 01 Jan 2010 00:00:00 +0100

Conclusion: The case highlights the problem in differentiating marked papillomatosis from a malignant lesion of breast and importance of biopsy with immunohistochemistry in such cases for proper management. PMID: 20090236 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

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A case of solitary spleen metastasis of endometrial carcinoma.

Ai Zheng — Thu, 31 Dec 2009 11:48:57 +0100

Authors: Wei SZ, Liu ZH Spleen metastasis is rare, solitary spleen metastasis of endometrial carcinoma is extremely rare. In our hospital, a 54-year-old woman had undergone operation, chemotherapy and radiotherapy for poorly differentiated endometrial adenocarcinoma. One year later, B-ultrasound and CT scan discovered a spleen occupying lesion. Spleen fine needle aspiration biopsy showed metastasis from endometrial carcinoma. Splenectomy was performed to remove the spleen lesion from the peritoneal cavity and postoperative pathologic examination confirmed that the spleen metastasis was of endometrial origin. After splenectomy, the patient received six cycles of chemotherapy with paclitaxel. To date, 12 months after splenectomy, she is alive with no intraperitoneal disease and with no o...

Diagnosing Breast Cancer: Needle Biopsy Best?

Medscape Today Headlines — Thu, 17 Dec 2009 20:39:09 +0100

A needle biopsy is safer and nearly as good as surgery at diagnosing breast cancer, according to researchers. WebMD Health News (Source: Medscape Today Headlines)

Non-surgical Method For Diagnosing Breast Cancer Safe, Nearly As Effective As Surgical Biopsy, New Report Finds

Health News from Medical News Today — Wed, 16 Dec 2009 13:00:00 +0100

Some methods of minimally invasive biopsy for breast cancer are nearly as accurate as surgical biopsy but have much less risk of harms, according to a new report funded by HHS' Agency for Healthcare Research and Quality (AHRQ). The report, prepared by the ECRI Institute's Evidence-based Practice Center under contract to AHRQ's Effective Health Care Program, compares traditional surgical biopsies with various types of "core needle biopsies," which involve removing tissue through a special large hollow needle inserted through the skin... (Source: Health News from Medical News Today)

Core needle biopsy procedures may be reasonable alternative to surgical biopsy for breast cancer

HemOncToday.com — Wed, 16 Dec 2009 08:59:00 +0100

(Source: HemOncToday.com)

Needle Biopsy Works Well in Diagnosing Breast Cancer

MedicineNet Cancer General — Wed, 16 Dec 2009 07:00:00 +0100

Title: Needle Biopsy Works Well in Diagnosing Breast CancerCategory: Health NewsCreated: 12/15/2009 12:10:00 PMLast Editorial Review: 12/16/2009 (Source: MedicineNet Cancer General)

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AHRQ: Core-needle biopsy comparable to surgical biopsy for breast cancer diagnosis

Health Imaging News — Tue, 15 Dec 2009 18:25:03 +0100

Non-surgical methods can be just as effective in the diagnosis of breast cancer as the option of surgical biopsy, which carries greater risk of harm to the patient, said a new report issued by the Department of Health and Human Services' Agency for Healthcare Research and Quality's (AHRQ) Effective Healthcare program. (Source: Health Imaging News)

AHRQ: Core-needle biopsy comparable to surgical biopsy for breast cancer diagnosis

Health Imaging News — Tue, 15 Dec 2009 18:25:03 +0100

Needle Biopsy Works Well in Diagnosing Breast Cancer

MedlinePlus Health News — Tue, 15 Dec 2009 17:00:00 +0100

It's nearly as accurate a surgical method, with fewer complications, analysis finds Source: HealthDay Related MedlinePlus Topic: Breast Cancer (Source: MedlinePlus Health News)

News From Annals Of Internal Medicine: Dec. 15, 2009

Breast Cancer News From Medical News Today — Tue, 15 Dec 2009 10:00:00 +0100

News From Annals Of Internal Medicine: Dec. 15, 2009

Health News from Medical News Today — Tue, 15 Dec 2009 10:00:00 +0100

1. Less Invasive Core Needle Biopsy Almost as Effective as Open Surgical Biopsy for Breast Lesion Diagnosis Women suspected of having breast cancer are usually referred for a breast biopsy to determine whether the lesion is cancerous. In most cases, breast lesions are not cancers and do not require further treatment. Biopsies may be performed using minimally invasive core needle biopsy or open surgical biopsy. Researchers reviewed more than 70 published articles to assess the risks and benefits of these two different methods... (Source: Health News from Medical News Today)

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News From Annals Of Internal Medicine: Dec. 15, 2009

Medical Students News From Medical News Today — Tue, 15 Dec 2009 10:00:00 +0100

Breast Cancer Needle Biopsy Results Similar to Open Biopsy

Modern Medicine — Tue, 15 Dec 2009 00:00:00 +0100

Using stereotactic- and ultrasound-guided core needle biopsy to conduct breast biopsies gives results almost as accurate as open surgical biopsy, and carries a lower risk of complications, according to a study published online Dec. 14 in the Annals of Internal Medicine. (Source: Modern Medicine)

Diagnosing Breast Cancer: Needle Biopsy Best?

WebMD Health — Mon, 14 Dec 2009 05:00:00 +0100

A less invasive needle biopsy may nearly as effective as surgical biopsy at diagnosing breast cancer with far fewer side effects. (Source: WebMD Health)

Systematic Review: Comparative Effectiveness of Core-Needle and Open Surgical Biopsy to Diagnose Breast Lesions.

Annals of Internal Medicine — Mon, 14 Dec 2009 00:00:00 +0100

Conclusion: Stereotactic- and ultrasonography-guided core needle biopsy procedures seem to be almost as accurate as open surgical biopsy, with lower complication rates. PMID: 20008742 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)

Residual Nodal Disease in Biopsy Proven N1/N2 Breast Cancer Following Neoadjuvant Systemic Therapy

World Journal of Surgery — Sat, 12 Dec 2009 14:15:47 +0100

Conclusions Twenty-five percent of patients who underwent neoadjuvant chemotherapy had a complete pathologic response in the nodal basin, whereas no patient who underwent neoadjuvant endocrine therapy experienced a complete nodal response. Summary Twenty-five percent of patients who underwent neoadjuvant chemotherapy had a complete pathological response in the nodal specimen, whereas no patient who underwent neoadjuvant endocrine therapy experienced a complete nodal response. Content Type Journal ArticleDOI 10.1007/s00268-009-0328-4Authors Fatema Al Mushawah, Washington University School of Medicine Department of Surgery 660 S. Euclid Avenue Campus Box 8109 St. Louis MO 63110 USAMarcus C. Tan, Washington University School of Medicine Department of Su...

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New ultrasound-based imaging technologies are claimed to avoid unnecessary breast biopsies, but what is an "unnecessary" image-guided needle biopsy of the breast?

Journal of Clinical Ultrasound — Fri, 11 Dec 2009 00:00:00 +0100

No abstract. (Source: Journal of Clinical Ultrasound)

Flat epithelial atypia is a common subtype of B3 breast lesions and is associated with noninvasive cancer but not with invasive cancer in final excision histology

Human Pathology — Fri, 11 Dec 2009 00:00:00 +0100

Summary: The biological behavior and the optimal management of benign breast lesions with uncertain malignant potential, the so-called B3 lesions, found in breast needle core biopsies is still under debate. We addressed this study to compare histologic findings in B3 needle core biopsies with final excision specimens to determine associated rates of malignancy. Consecutive needle core biopsies were performed in a 3-year period (January 1, 2006-December 31, 2008). Biopsies were image-guided (31 by ultrasound, 85 stereotactic vacuum-assisted, 6 unknown) for evaluation of breast abnormalities. We reviewed 122 needle core biopsies with B3 lesions of 91 symptomatic patients and 31 screen-detected women and compared the B3 histologic subtypes with the final excision histology. A total of 1845 ne...

Risk Factors for Malignancy in Benign Papillomas of the Breast on Core Needle Biopsy

World Journal of Surgery — Thu, 10 Dec 2009 00:12:23 +0100

Conclusions Breast lesions diagnosed as benign papillomas on CNB had a 6.3% risk of being malignant. The risk was highest for lesions that were palpable and detectable as a mass on a mammogram. In addition, the low-risk patients avoid immediate surgical excision, although they should be followed carefully. Content Type Journal ArticleDOI 10.1007/s00268-009-0313-yAuthors So-Youn Jung, National Cancer Center Center for Breast Cancer, Research Institute and Hospital 111 Jungbalsan-ro, Ilsandong-gu, Goyang-si Gyeonggi-do 410-769 Republic of KoreaHan-Sung Kang, National Cancer Center Center for Breast Cancer, Research Institute and Hospital 111 Jungbalsan-ro, Ilsandong-gu, Goyang-si Gyeonggi-do 410-769 Republic of KoreaYoungmee Kwon, National Cancer Center Center for Breas...

Towards an optical biopsy for the diagnosis of breast cancer in vivo by endogenous fluorescence spectroscopy

Journal of Biophotonics — Wed, 02 Dec 2009 00:00:00 +0100

The techniques of medical imaging allow the detection of suspect lesions in the breast, but they do not always evidence the malignant nature of these lesions. Breast biopsies and histological analyses are therefore implemented to establish a diagnosis. In order to reduce the number of these invasive procedures, a portable clinical system was designed based upon the excitation of Endogenous Fluorescence in vivo at 405 nm via a fiber-optics probe included in a disposable needle of small diameter ( (Source: Journal of Biophotonics)

Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast?

American Journal of Surgery — Tue, 01 Dec 2009 00:00:00 +0100

Conclusions: Excisional biopsy for lobular neoplasia did not identify understaged carcinoma or alter the rate of subsequent carcinoma. The subsequent carcinoma risk is diffuse and bilateral; it does not correlate with the site at which lobular neoplasia was diagnosed. (Source: American Journal of Surgery)

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Adequate histologic sampling of breast magnetic resonance imaging-guided core needle biopsy.

Archives of Pathology and Laboratory Medicine — Tue, 01 Dec 2009 00:00:00 +0100

Conclusions.-Needle core biopsies for MRI-detected abnormalities should be routinely examined at only 1 level. Further levels may be needed in occasional cases to identify more conclusively an associated pathologic abnormality and may be of particular value when assessing atypical intraductal proliferative epithelial lesions. PMID: 19961252 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

[Immunohistochemical phenotype of breast carcinomas predicts the eff ectiveness of primary systemic therapy.]

Magyar Onkologia — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Kulka J, Tokés AM, Tóth AI, Szász AM, Farkas A, Borka K, Járay B, Székely E, Istók R, Lotz G, Madaras L, Korompay A, Harsányi L, László Z, Rusz Z, Molnár BA, Molnár IA, Kenessey I, Szentmártoni G, Székely B, Dank M The purpose of the study was to identify breast cancer subtypes by immunohistochemistry likely to respond to neoadjuvant chemotherapy and to analyze the used chemotherapy regimen and the range of response rates. Analysis of a collected database was performed. Ninety-two patients were identified in our files who received neoadjuvant chemotherapy between 1998 and 2009. We used immunohistochemical profiles (ER, PgR, HER2, Ki-67 and p53) of NCB, FNAB and surgical breast specimens to subclassify the tumors....

Correlation of needle core biopsy with excision histology in screen-detected B3 lesions: the Merrion Breast Screening Unit experience

Journal of Clinical Pathology — Fri, 27 Nov 2009 18:03:23 +0100

Conclusions: One-sixth of B3 NCBs in this series proved to be malignant on excision. The PPV for malignancy varied according to lesion type. (Source: Journal of Clinical Pathology)

Radiofrequency ablation of breast cancer: a comparative study of two needle designs.

Breast Cancer — Fri, 27 Nov 2009 00:00:00 +0100

CONCLUSIONS: Cool-tip and LeVeen systems had the same efficacy in ablation of breast cancer, but Cool-tip was easier to insert and had a shorter ablation time. PMID: 19943129 [PubMed - as supplied by publisher] (Source: Breast Cancer)

Axillary and intramammary lymphadenopathy caused by Kikuchi-Fujimoto disease mimicking malignant lymphoma.

Breast Cancer — Fri, 27 Nov 2009 00:00:00 +0100

We describe a rare case of intramammary and axillary lymphadenopathy caused by Kikuchi-Fujimoto disease (KFD). A 30-year-old woman presented with enlarged axillary lymph nodes and a right breast mass with tenderness. Computed tomography, ultrasonography, F-2-deoxy-fluoro-D: -glucose positron emission tomography and fine-needle aspiration cytology were performed, and malignant lymphoma (ML) was suspected. Histological diagnosis of a needle biopsy and surgical specimen showed histiocytic necrotizing lymphadenitis. It is important to differentiate KFD from ML because of differences in treatment choice and clinical outcome. PMID: 19943128 [PubMed - as supplied by publisher] (Source: Breast Cancer)

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Significance of incidental detection of filariasis on aspiration smears: A case series

Diagnostic Cytopathology — Wed, 25 Nov 2009 00:00:00 +0100

Filariasis is a major public health problem in tropical and subtropical countries including India. Although there are reports of incidentally diagnosed cases of lymphatic filariasis in the existing literature, the significance of this finding needs to be summarised in one place. The association of filariasis with neoplasms is still debatable.For this series, cases diagnosed as filariasis on aspiration cytology (with or without coexistent pathology) over a period of 1 year were retrieved. The cases with a clinical suspicion of filariasis were excluded. Hence, five cases with incidental diagnosis of filariasis on aspiration cytology were included. The site of aspiration included one case each of thyroid, breast, bone marrow, cervical lymph node, and subcutaneous nodule. Of these, three cases...

Discordance between core needle biopsy (CNB) and excisional biopsy (EB) for estrogen receptor (ER), progesterone receptor (PgR) and HER2 status in early breast cancer (EBC)

Annals of Oncology — Tue, 24 Nov 2009 15:28:25 +0100

Conclusions: CNB can be used with confidence for ER and HER2 determination. For PgR, due to a substantial discordance between CNB and EB, results from CNB should be used with caution. (Source: Annals of Oncology)

Sclerosing polycystic adenosis of the parotid gland: Report of one case diagnosed by fine-needle cytology with in situ malignant transformation

Diagnostic Cytopathology — Mon, 23 Nov 2009 00:00:00 +0100

Sclerosing polycystic adenosis (SPA) is a rare pathological condition affecting the salivary glands, first described by Smith etal. in 1996. Even though this lesion is being increasingly diagnosed, less than 50 cases have been published in the world literature to date. In line with numerous other pathological analogies between breast and salivary gland lesions, SPA shares with fibrocystic disease of the breast many histopathological features, i.e., fibrosis, oncocytic (apocrine) changes, hyperplasia of ductal and acinar epithelium, cystic dilation of ducts, and, often, atypical epithelial changes. Most of the described cases have followed a benign clinical course, despite the frequent possibility of atypical hyperplasia in more than 50% of the cases and of the more than occasional in situ ...

Halfpipe Coaxial Cannula for Self-Contained Vacuum-Assisted Biopsy Systems: Feasibility in a Pig Breast Model

American Journal of Roentgenology — Fri, 20 Nov 2009 19:03:24 +0100

CONCLUSION. Sampling was successful in 15 of 18 cases. Errors occurred only in superficial lesions biopsied via the vertical approach. The halfpipe coaxial cannula shows promise for improving positioning accuracy, avoiding target dislocation, and obviating repeated needle repositioning. (Source: American Journal of Roentgenology)

Preoperative Sonographic Classification of Axillary Lymph Nodes in Patients With Breast Cancer: Node-to-Node Correlation With Surgical Histology and Sentinel Node Biopsy Results

American Journal of Roentgenology — Fri, 20 Nov 2009 19:03:24 +0100

CONCLUSION. Sonographic classification of axillary lymph nodes is effective for predicting the presence of metastases to avoid sentinel node biopsy or to reduce unsuccessful lymphatic mapping during sentinel node biopsy. (Source: American Journal of Roentgenology)

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Columnar cell lesions and pseudoangiomatous hyperplasia like stroma: is there an epithelial-stromal interaction?

International Journal of Clinical and Experimental Pathology — Thu, 19 Nov 2009 10:38:02 +0100

Authors: Recavarren RA, Chivukula M, Carter G, Dabbs DJ The significance of association between cancer and its microenvironment has been increasingly recognized. It has been shown in animal models that interaction between neoplastic epithelial cells and adjacent stroma can modulate tumor behavior. Carcinoma associated stromal cells can transform normal epithelial cells into neoplastic cells. In breast, columnar cell lesions are non-obligate precursors of low grade ductal carcinoma in situ. Columnar cell lesions can be seen intimately associated with PASH-like-stroma, a lesion we termed as CCPLS. Our aim is to investigate epithelial-stromal interactions in CCPLS and compare them to PASH without columnar cell lesions in breast core needle biopsies. Normal terminal duct lobular unit (TDLU...

Clinical Implications of Subcategorizing BI-RADS 4 Breast Lesions associated with Microcalcification: A Radiology–Pathology Correlation Study

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

Abstract: Currently radiologists have the option of subcategorizing BI-RADS 4 breast lesions into 4A (low suspicion for malignancy), 4B (intermediate suspicion of malignancy), and 4C (moderate concern, but not classic for malignancy). To determine the clinical significance of BI-RADS 4 subcategories and the common pathologic changes associated with these mammographic lesions, a retrospective review of 239 consecutive stereotactic-needle core biopsies (SNCB) for microcalcifications was performed. All 239 SNCBs were BI-RADS 4 lesions, and of these, 191 were subcategorized to 4A, 4B or 4C. Ninety-four of 191 (49%) were 4A, 73 (38%) were 4B, and 24 (13%) were 4C. Fibrocystic change was the most common finding (66/239; 28%) followed by ductal carcinoma in situ (DCIS) accounting for 23% of cases...

Bard Peripheral Vascular Inc - Needle, Biopsy - Class 2 Recall

Medical Device Recalls since July 07, 2006 — Wed, 18 Nov 2009 02:00:26 +0100

Bard Magnum Disposable Biopsy Core Needle 16 gauge, Catalog Number: MN1616. Bard Magnum Disposable Biopsy Core Needle is intended for use in obtaining biopsies from soft tissues such as liver, kidney, prostate, breast, spleen, lymph nodes and various soft tissue tumors. (Source: Medical Device Recalls since July 07, 2006)

Bard Peripheral Vascular Inc - Needle, Biopsy - Class 2 Recall

Medical Device Recalls since July 07, 2006 — Wed, 18 Nov 2009 02:00:26 +0100

Bard Magnum Disposable Biopsy Core Needle 16 gauge, Catalog Number: MN1610. Bard Magnum Disposable Biopsy Core Needle is intended for use in obtaining biopsies from soft tissues such as liver, kidney, prostate, breast, spleen, lymph nodes and various soft tissue tumors (Source: Medical Device Recalls since July 07, 2006)

Bard Peripheral Vascular Inc - Needle, Biopsy - Class 2 Recall

Medical Device Recalls since July 07, 2006 — Wed, 18 Nov 2009 02:00:26 +0100

Bard Magnum Disposable Biopsy Core Needle 16 gauge, Catalog Number: MN1620. Bard Magnum Disposable Biopsy Core Needle is intended for use in obtaining biopsies from soft tissues such as liver, kidney, prostate, breast, spleen, lymph nodes and various soft tissue tumors. (Source: Medical Device Recalls since July 07, 2006)

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Bard Peripheral Vascular Inc - Needle, Biopsy - Class 2 Recall

Medical Device Recalls since July 07, 2006 — Wed, 18 Nov 2009 02:00:26 +0100

Bard Magnum Disposable Biopsy Core Needle 16 gauge, Catalog Number: MN1613. Bard Magnum Disposable Biopsy Core Needle is intended for use in obtaining biopsies from soft tissues such as liver, kidney, prostate, breast, spleen, lymph nodes and various soft tissue tumors. (Source: Medical Device Recalls since July 07, 2006)

Primary epithelioid angiosarcoma of the breast masquerading as carcinoma

Current Oncology — Tue, 17 Nov 2009 16:12:53 +0100

ABSTRACT Here we report a case of primary epithelioid angiosarcoma (eas) of the breast occurring in a 30-year-old woman. Following fine-needle asspiration cytology (fnac) and tru-cut biopsy, the patient was initially diagnosed with mammary carcinoma and thereafter underwent modified radical mastectomy. Postoperative histopathologic examination and immunohistochemistry revealed a diagnosis of primary epithelioid angiosarcoma of the breast. The patient received postoperative radiotherapy to the chest wall and was started on adjuvant thalidomide. Preoperatively, eas can be mistaken for carcinoma because it is difficult to appreciate the typical morphology on fnac or tru-cut biopsy. Indeed, this is an area of potential diagnostic error because, nowadays, neoadjuvant therapy is often instituted...

Accuracy of preoperative ultrasound and ultrasound-guided fine needle aspiration cytology for axillary staging in breast cancer

ANZ Journal of Surgery — Thu, 12 Nov 2009 00:00:00 +0100

Conclusions: Preoperative axillary ultrasound in combination with US-FNAC provides a simple, minimally invasive and reliable approach to the initial determination of the axillary LN status. Those who are US-FNAC positive can be referred for axillary LN dissection without sentinel LN biopsy. (Source: ANZ Journal of Surgery)

Microbubble Technique Permits SLN Staging Before Breast Cancer Surgery

OncologySTAT What Patients Are Reading — Wed, 11 Nov 2009 13:51:15 +0100

Spread of breast cancer to the sentinel lymph node can be detected by a simple technique using microbubbles and fine-needle biopsy, rather than surgery. The technique takes only a few minutes and permits... (Source: OncologySTAT What Patients Are Reading)

A unique proteolytic fragment of alpha1-antitrypsin is elevated in ductal fluid of breast cancer patient

Breast Cancer Research and Treatment — Mon, 09 Nov 2009 18:26:47 +0100

In conclusion, elevated C-41/42 is likely the result of elevated AAT synthesis, and the activity of specific MMPs present within the tumor. As other C-terminal fragments of AAT are reported to function as tumor-derived suppressors to the host immune-system, elevated C-41/42 may also be predictive of a poor outcome. Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-009-0625-5Authors Junma Zhou, Johns Hopkins Medical Institutions Department of Pathology Baltimore MD 21287 USABruce Trock, Johns Hopkins Medical Institutions Department of Urology Baltimore MD 21287 USATheodore N. Tsangaris, Johns Hopkins Medical Institutions Department of Surgery Baltimore MD 21287 USANeil B. Friedman, Hoffberger Breast Center at Mercy Hospital Baltimore MD 21202 USADeanna Shapiro,...

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Three-Dimensional Ultrasound Guidance of Autonomous Robotic Breast Biopsy: Feasibility Study

Ultrasound in Medicine and Biology — Mon, 09 Nov 2009 00:00:00 +0100

Abstract: Feasibility studies of autonomous robot biopsies in tissue have been conducted using real-time three-dimensional (3-D) ultrasound combined with simple thresholding algorithms. The robot first autonomously processed 3-D image volumes received from the ultrasound scanner to locate a metal rod target embedded in turkey breast tissue simulating a calcification, and in a separate experiment, the center of a water-filled void in the breast tissue simulating a cyst. In both experiments the robot then directed a needle to the desired target, with no user input required. Separate needle-touch experiments performed by the image-guided robot in a water tank yielded an rms error of 1.15 mm. (E-mail: kaicheng.liang@duke.edu) (Source: Ultrasound in Medicine and Biology)

Spontaneous infarction of pleomorphic adenoma: Report of a case simulating malignancy on fine-needle cytology sample

Diagnostic Cytopathology — Thu, 05 Nov 2009 00:00:00 +0100

Ischemic or hemorrhagic infarction has been described as an uncommon but possible complication of fine-needle cytology sampling in numerous organs, more frequently the thyroid, the salivary glands, the breast, the lymph node, and the kidney. In these situations, infarction appears to be directly related to the vascular disturbances caused by needle sampling, though fine this latter might be. One case of a spontaneous infarction of a parotid pleomorphic adenoma in a 46-year-old lady is here described in which the cytopathologic findings, which were related to ischemic infarction, preceded fine-needle cytology sampling and mimicked malignancy.The cytopathologic picture showed a quizzical mixture of necrosis and inflammation coupled to hyperplastic changes of the acinar cells, oncocytic metap...

Twenty reasons why vitamin D is better than a swine flu vaccine

NaturalNews.com — Tue, 03 Nov 2009 07:00:00 +0100

(NaturalNews) The news is out: Vitamin D is better than the swine flu vaccine at halting H1N1 infections. In fact, without vitamin D, chances are that a vaccine won't generate much of an immune response in the first place.That's because vitamin D is essential for healthy, active immune function. That's just one of the reasons smart people are choosing vitamin D instead of the swine flu vaccine. Here are nineteen more reasons:#1 Vitamin D activates your immune system to respond to any viral exposure (not just one virus).#2 Vitamin D naturally belongs in your body.#3 Vitamin D has been functioning as medicine in the human body since the beginning of the human species.#4 Vitamin D is available right now and there's no shortage of it.#5 Vitamin D won't cause your brain to swell and put you int...

Technique Can Reduce Sentinel Node Biopsies in Early Breast Ca

Internal Medicine News — Sun, 01 Nov 2009 00:00:00 +0100

Adding ultrasound examination of axillary nodes and fine-needle aspiration of suspicious nodes prior to lumpectomy in women with early-stage breast cancer spared 17 (30%) of 57 women the need for sentinel node biopsy and a second surgery, a study of 274 patients found. (Source: Internal Medicine News)

Apocrine ductal carcinoma in situ involving a sclerosing lesion with adenosis: report of a case.

Archives of Pathology and Laboratory Medicine — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Visscher DW Apocrine metaplasia is a ubiquitous component of the mammary fibrocystic change spectrum. Although mostly associated with cysts, apocrine metaplasia can also present as a proliferative lesion, rarely with cytologic atypism. Apocrine atypia is characterized by 3-fold nuclear enlargement, multiple nucleoli, and hyperchromatism and generally arises in florid adenosis or radial sclerosing lesions. Dramatic apocrine atypia may be very difficult to distinguish from apocrine ductal carcinoma in situ. The latter is distinguished from apocrine atypia by greater extent of the lesion (>0.4 cm) and the presence of greater nuclear pleomorphism with nuclear membrane irregularity. The clinical significance of apocrine atypia is poorly understood and reflects the lack of publis...

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Technique May Reduce Biopsies in Early Breast Ca

Ob.Gyn. News — Sun, 01 Nov 2009 00:00:00 +0100

[Correction of breast Poland's anomalies. About eight cases and literature review.]

Annales de Chirurgie Plastique et Esthetique — Wed, 28 Oct 2009 00:00:00 +0100

CONCLUSION: The simplest and the fastest breast deformity correction technique in Poland's syndrome patients, the one with the least complications and cosmetic sequella and the most practiced by the surgeon, remains the best method for breast anomaly correction of Poland's syndrome. PMID: 19879029 [PubMed - as supplied by publisher] (Source: Annales de Chirurgie Plastique et Esthetique)

Analysis of false-negative results after US-guided 14-gauge core needle breast biopsy

European Radiology — Tue, 27 Oct 2009 18:26:44 +0100

Conclusions Most false negatives were found immediately and imaging-histological discordance was the most important clue. Careful correlation of clinical, radiological and histological results as well as appropriate follow-up is essential. Content Type Journal ArticleCategory BreastDOI 10.1007/s00330-009-1632-yAuthors Ji Hyun Youk, Yonsei University College of Medicine Department of Radiology, Research Institute of Radiological Science Seoul South KoreaEun-Kyung Kim, Yonsei University College of Medicine Department of Radiology, Research Institute of Radiological Science Seoul South KoreaMin Jung Kim, Yonsei University College of Medicine Department of Radiology, Research Institute of Radiological Science Seoul South KoreaJin Young Kwak, Yonsei University College of Me...

Intraoperative placement of MammoSite for breast brachytherapy treatment and seroma incidence

Brachytherapy — Fri, 23 Oct 2009 00:00:00 +0100

Conclusions: Meticulous wound care and postoperative antibiotics prevented acute infection. Infection was not a contributing factor for seroma formation in these patients. Placement of the MammoSite catheter by OCT did not increase the risk of CSS development, in postmenopausal breast cancer patients. (Source: Brachytherapy)

Predictive factors for breast cancer in patients diagnosed atypical ductal hyperplasia at core needle biopsy

World Journal of Surgical Oncology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions: Age (over 50-years) at the time of biopsy is an independent predictive factor for breast cancer at surgical excision in patients with diagnosed ADH at CNB. For patients diagnosed with ADH at CNB, only complete surgical excision is the suitable treatment option, because we could not find any combination of factors that can safely predict the absence of DCIS or invasive cancer in a case of ADH. (Source: World Journal of Surgical Oncology)

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[Atypical epithelial hyperplasia of the breast: Current state of knowledge and clinical practice.]

Journal de Gynecologie, Obstetrique et Biologie de la Reproduction — Wed, 21 Oct 2009 00:00:00 +0100

CONCLUSION: Because of high rate of breast cancer underestimation, surgical excision is necessary after the diagnosis of AEH at core needle biopsy. Surgical oncology rules and collaboration with radiologist are required for this surgery. A second operation was not required due to involved margins by AEH (except with pleiomorphic lobular neoplasia) because local control of breast cancer seems to be unchanged. Besides, hormonal replacement therapy for patient with AEH is not recommended because of lack of studies about this subject. PMID: 19853386 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)

Retrospective analysis of 119 Chinese noninflammatory locally advanced breast cancer cases treated with intravenous combination of vinorelbine and epirubicin as a neoadjuvant chemotherapy: a median follow-up of 63.4 months

BMC Cancer — Tue, 20 Oct 2009 23:00:00 +0100

This study is a retrospective evaluation of the efficacy of neoadjuvant chemotherapy (NC) with a vinorelbine (V) and epirubicin (E) intravenous combination regimen and is aimed at identification of predictive markers for the long-term outcome in noninflammatory locally advanced breast cancer (NLABC). Methods: One-hundred-and-nineteen patients with NLABC were identified from September 2001 to May 2006. Analysis was performed in March 2008, with a median follow-up of 63.4 months (range, 9-76 months). All patients were diagnosed with invasive breast cancer using 14G core needle biopsy and treated with three cycles of VE before surgery. Local-regional radiotherapy was offered to all patients after the completion of chemotherapy followed by hormonal therapy according to hormone receptor status....

Biopsy Method: A Major Predictor of Adherence After Benign Breast Biopsy?

American Journal of Roentgenology — Tue, 20 Oct 2009 18:02:35 +0100

CONCLUSION. Women more often adhere to clinical recommendations for follow-up sessions comprising mammography. Patient age and whether biopsy complications occurred also seem to modify compliance. Further studies should assess whether superior compliance after vacuum-assisted breast biopsy persists in other settings, such as with stereotactic or ultrasound guidance, different numbers of cores, and procedures of various durations. (Source: American Journal of Roentgenology)

What Causes Breast Calcifications?

Dr. Weil Q&A — Mon, 19 Oct 2009 15:15:14 +0100

I am having a needle biopsy for the third time in five years for breast calcifications. I am puzzled as to why I keep getting these when I have very healthy eating habits, do not smoke, exercise daily, and have no family history of breast problems. What can I do to avoid the breast calcifications? This is very frustrating. (Source: Dr. Weil Q&A)

Mastectomy for C5 cytology- is it safe practice?

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:47:10 +0100

Introduction: To evaluate the accuracy of cytological diagnosis of breast cancers greater than 11mm in detecting invasive cancers and therefore the ability to use fine needle aspiration (FNA) as the sole diagnostic parameter. (Source: European Journal of Surgical Oncology)

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Reporting rates of cellular atypia in patients with (B3) lesions of uncertain malignant potential on breast needle core biopsy, and their clinical significance

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:47:05 +0100

Introduction: Around 5% of breast needle core biopsies (NCB) are reported as B3 - uncertain malignant potential. Cellular atypia appears to be an important determinant. In the absence of National Health Service Breast Screening Programme (NHSBSP) quality assurance targets to report cellular atypia in NCB specimens, this study sought to establish the proportion of histopathological reports for B3 lesions referring to cellular atypia, their subsequent diagnostic management and clinical significance. (Source: European Journal of Surgical Oncology)

Assessment of preoperative axillary ultrasound in breast carcinoma

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:47:04 +0100

Introduction: The use of SLNB to stage early breast cancer is now routine. The current NICE guidance recommends pre-operative ultrasound (U/S) evaluation of the axilla and ultrasound-guided needle sampling of abnormal lymph nodes. (Source: European Journal of Surgical Oncology)

Accuracy of preoperative axillary ultrasound and guided fine needle aspiration cytology of equivocal and abnormal nodes in predicting axillary node status in breast cancer

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:47:04 +0100

Introduction: The superiority of ultrasound (US) over clinical examination in the assessment of axillary nodes in patients with breast carcinoma is well recognised. The aim of the study is to evaluate the role of US-guided fine needle aspiration cytology (FNAC) of nodes deemed equivocal or abnormal on US, in choosing the appropriate initial axillary procedure. (Source: European Journal of Surgical Oncology)

Pathological and patient factors affecting the accuracy of ultrasound combined with fine needle aspiration cytology in pre-operative staging of the axilla in breast cancer

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:46:59 +0100

Introduction: Ultrasound combined with fine needle aspiration cytology is effective in pre-operative staging of the axilla in breast cancer. Accurate pre-operative diagnosis of lymph node metastases allows for a one stage axillary operation and may also influence decisions regarding neo-adjuvant chemotherapy and breast reconstruction. The aim of this study is to identify pathological and patient factors that influence the accuracy of ultrasound and FNAC in determining the status of the axilla pre-operatively. (Source: European Journal of Surgical Oncology)

Grading of breast cancer; consistency between core biopsy and surgical specimen

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:46:55 +0100

Methods: Core biopsies are not only essential in the diagnosis of breast cancer but also in directing management and making informed choices. The size and grade of the tumour may influence decisions concerning breast conservation, primary chemotherapy and type of axillary surgery. The reliability of the core biopsy result is important and we therefore aimed to assess the consistency of grades of cancer between the initial core biopsy and the final surgical specimen. We performed a prospective audit of all core biopsies performed over a 12-month period. All invasive cancers were included if they went on to have immediate primary surgery. Biopsies were performed using a 14 gauge needle (2-9 cores per patient). The histology of the core and final specimen were doubly reported by 2 separate co...

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Ultrasound and fine needle aspiration cytology of the axilla in the pre-operative identification of axillary nodal involvement in breast cancer

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:46:43 +0100

Conclusion: US with FNAC of the most abnormal node allows pre-operative detection of a third of node positive axillae in screen-detected and over 40% of those with symptomatic breast cancer, allowing one-stage axillary surgery avoiding the sentinel node biopsy step in these patients. (Source: European Journal of Surgical Oncology)

Invasive papillary carcinoma of the male breast: Report of a rare case and review of the literature

Journal of Cancer Research and Therapeutics — Fri, 16 Oct 2009 12:45:52 +0100

Pant Ishita, Joshi Sanjeev ChandraJournal of Cancer Research and Therapeutics 2009 5(3):216-218Breast masses occur in men far less commonly than women. Papillary lesions of the male breast are rare and comprise a spectrum of lesions ranging from benign intraductal papilloma to intraductal papillary carcinoma and invasive papillary carcinoma. In this case report, a 78-year-old man presented with a subareolar painless mass. Fine needle aspiration cytology (FNAC) was performed. Cytologic examination revealed a cellular aspirate. A diagnosis of papillary lesion favoring papillary carcinoma was rendered. The patient underwent modified radical mastectomy, which showed invasive papillary carcinoma. As far as we know, only a few cases of invasive papillary carcinoma of the male breast have been pu...

Cell blocks allow reliable evaluation of expression of basal (CK5/6) and luminal (CK8/18) cytokeratins and smooth muscle actin (SMA) in breast carcinoma

Cytopathology — Wed, 14 Oct 2009 23:00:00 +0100

Conclusion: The identification of CK5/6, CK8/18 and SMA by immunohistochemistry in cell blocks can be a reliable method that yields results close to those obtained in surgical specimens, and can contribute to the classification of breast carcinomas with luminal and basal expression patterns, providing helpful information in the choice of treatment and in the evaluation of prognostic and predictive factors. (Source: Cytopathology)

Lymphoepithelioma-like Carcinoma of the Breast: Diagnosis by Core Needle Biopsy

The Breast Journal — Sun, 11 Oct 2009 23:00:00 +0100

(Source: The Breast Journal)

Interstitial Laser Therapy of Breast Fibroadenomas With 6 and 8 Year Follow-Up

The Breast Journal — Sun, 11 Oct 2009 23:00:00 +0100

Abstract: Fibroadenomas are non-cancerous breast tumors commonly seen in teenagers but also found in women at the time of first mammogram. They have distinct physical findings and imaging features but the definitive diagnosis is made by ultrasound or stereotactic guided needle biopsy. Treatment options are observation or surgical removal. Recently, removal by ultrasound-guided technique has been reported. Alternatively, the tumor may be ablated within the breast by cold (cryotherapy) or by heat (laser, radiofrequency, focused ultrasound and microwave). In this paper the laser treatment in two patients, one with bilateral fibroadenomas, with 6 and 8 year follow-up is presented. (Source: The Breast Journal)

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Sentinel Lymph Node Detection in Breast Cancer Patients by Real-Time Virtual Sonography Constructed With Three-Dimensional Computed Tomography-Lymphography

The Breast Journal — Sun, 11 Oct 2009 23:00:00 +0100

Abstract: Ultrasonography (US) is one tool for preoperative diagnosis of lymph node metastases in breast cancer. However, US cannot detect true sentinel lymph nodes (SLNs). We identified SLNs in 60 clinically node-negative breast cancer patients using a real-time virtual sonography (RVS) system to display in real time a virtual multi-planar reconstruction obtained from computed tomography (CT) volume data corresponding to the same cross-sectional image from US. CT volume data were obtained from our original three-dimensional CT lymphography (3DCT-LG), which accurately detects SLNs in breast cancer. SLN metastases were assessed by shape and visibility of the hilum. All patients underwent SLN biopsy and SLN metastases were examined pathologically. In all 60 patients, we were able to detect t...

Needle biopsy called the gold standard

Health News - UPI.com — Fri, 09 Oct 2009 20:36:19 +0100

LOS ANGELES, Oct. 9 (UPI) -- A third of U.S. women suspected of having breast cancer get open surgery biopsies, though the needle biopsy represents "best practice," researchers say. (Source: Health News - UPI.com)

Needle Biopsy Is Gold Standard For Breast Cancer Diagnosis: Surgeons' Unanimous Consensus

Health News from Medical News Today — Fri, 09 Oct 2009 07:00:00 +0100

A special report published in the October issue of the Journal of the American College of Surgeons indicates that an alarming 35% of initial diagnostic breast biopsies in the United States are still being done using unnecessary open surgical techniques. This in spite of the fact that it costs as much as three times more than the much less invasive and equally accurate needle biopsy technique. (Source: Health News from Medical News Today)

Tiny Chip Can Measure Estrogen in Breast Tissue

Medscape Medical News Headlines — Thu, 08 Oct 2009 17:32:02 +0100

A new pocket-sized microchip device can measure estrogen levels in breast tissue in just a few minutes using a few drops of blood or needle aspirates, Canadian researchers said on Wednesday. Reuters Health Information (Source: Medscape Medical News Headlines)

Lab-on-a-chip would measure estrogen with a poke

CTV Health — Thu, 08 Oct 2009 14:43:52 +0100

Estrogen fuels breast cancer yet doctors can't measure how much of the hormone is in a woman's breast without cutting into it. A Canadian invention might change that: A lab-on-a-chip that can do the work quickly with just the poke of a small needle. (Source: CTV Health)

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Needle biopsy best for breast cancer diagnosis

AuntMinnie.com Headlines — Thu, 08 Oct 2009 07:00:00 +0100

A panel of leading breast disease specialists has agreed that percutaneous needle biopsy should be the standard for initial diagnosis of breast abnormalities, according to a report published in this month's Journal of the American College of Surgeons. (Source: AuntMinnie.com Headlines)

Technique May Spare Biopsies in Early Breast Cancer

OncologySTAT Latest News — Wed, 07 Oct 2009 14:05:34 +0100

Researchers invent lab-on-a-chip to measure estrogen in women's breast with just a needle poke

OrlandoSentinel: Medical Research — Wed, 07 Oct 2009 10:05:00 +0100

WASHINGTON (AP) — Estrogen fuels breast cancer yet doctors can't measure how much of the hormone is in a woman's breast without cutting into it. A Canadian invention might change that: A lab-on-a-chip that can do the work quickly with just the... (Source: OrlandoSentinel: Medical Research)

Surgeons' unanimous consensus: Needle biopsy is gold standard for breast cancer diagnosis

EurekAlert! - Medicine and Health — Wed, 07 Oct 2009 04:00:00 +0100

(Hoag Memorial Hospital Presbyterian) A special report published in the October issue of the Journal of the American College of Surgeons indicates that an alarming 35 percent of initial diagnostic breast biopsies in the United States are still being done using unnecessary open surgical techniques. This in spite of the fact that it costs as much as three times more than the much less invasive and equally accurate needle biopsy technique. (Source: EurekAlert! - Medicine and Health)

Surgeons' Unanimous Consensus: Needle Biopsy Is Gold Standard For Breast Cancer Diagnosis

ScienceDaily Headlines — Wed, 07 Oct 2009 04:00:00 +0100

A new report indicates that an alarming 35 percent of initial diagnostic breast biopsies in the United States are still being done using unnecessary open surgical techniques. This in spite of the fact that it costs as much as three times more than the much less invasive and equally accurate needle biopsy technique. (Source: ScienceDaily Headlines)

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ASCO Breast: Preop Lymph Node Ultrasound Prevents Second Surgeries (CME/CE)

MedPage Today Hematology/Oncology — Tue, 06 Oct 2009 22:00:00 +0100

SAN FRANCISCO (MedPage Today) -- Ultrasound of axillary lymph nodes before breast cancer surgery, with fine-needle aspiration for confirmation of metastases, could spare many early-stage patients from sentinel node biopsy and reoperation, researchers here said. (Source: MedPage Today Hematology/Oncology)

Freehand Versus Guided Breast Biopsy: Comparison of Accuracy, Needle Motion, and Biopsy Time in a Tissue Model

Medscape Radiology Headlines — Mon, 05 Oct 2009 16:56:09 +0100

How does the currently used freehand technique for breast biopsy compare with the use of a needle guidance system that limits needle motion to within the ultrasound scanning plane? American Journal of Roentgenology (Source: Medscape Radiology Headlines)

Phyllodes Tumour of the Breast: Clinicopathological Analysis of Recurrent vs. Non-recurrent Cases.

Asian Journal of Surgery — Thu, 01 Oct 2009 00:00:00 +0100

CONCLUSION: WLE seems to be the initial procedure of choice for all PTs, and mastectomy for recurrent tumours. Further studies are needed to define the role of adjuvant therapies. PMID: 19892625 [PubMed - in process] (Source: Asian Journal of Surgery)

What do breast surgeons do?

American Journal of Surgery — Wed, 30 Sep 2009 23:00:00 +0100

Conclusions: The specialty of breast surgery is unique in its nonoperative volume and extensive duration of follow-up. Strategies need to be designed to make this process more time-efficient for the surgeon. (Source: American Journal of Surgery)

A case of metastatic melanoma in the breast with unknown primary site, diagnosed by fine needle aspiration cytology.

Indian Journal of Pathology and Microbiology — Wed, 30 Sep 2009 23:00:00 +0100

Authors: Wilkinson AR, Mahore SD, Bothale KA PMID: 19805989 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

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Fluorescence Spectroscopy: An Adjunct Diagnostic Tool to Image-Guided Core Needle Biopsy of the Breast

IEEE Transactions on Biomedical Engineering — Wed, 30 Sep 2009 23:00:00 +0100

This study demonstrates the feasibility of performing fluorescence spectroscopy during clinical core needle breast biopsy, and the potential of this technique for identifying breast malignancy in vivo. (Source: IEEE Transactions on Biomedical Engineering)

Role of axillary ultrasound in the preoperative diagnosis of lymph node metastases in patients affected by breast carcinoma

La Radiologia Medica — Wed, 30 Sep 2009 18:27:37 +0100

Conclusions In 48.3% of patients, the combination of axillary US and FNAC guided treatment decisions towards immediate axillary dissection, thus sparing the patients sentinel node biopsy, with a significant reduction of costs and hospitalization time. Content Type Journal ArticleCategory Breast Radiology/SenologiaDOI 10.1007/s11547-009-0465-8Authors A. Luparia, Università di Torino, ASO San Giovanni Battista di Torino, Sede Molinette Istituto di Radiologia Diagnostica ed Interventistica Via Genova 3 10126 Torino ItalyP. Campanino, Università di Torino, ASO San Giovanni Battista di Torino, Sede Molinette Istituto di Radiologia Diagnostica ed Interventistica Via Genova 3 10126 Torino ItalyR. Cotti, Università di Torino, ASO San Giovanni Battista di Torino, Sede Moline...

Endobronchial metastasis from oral fibrosarcoma 13 years after treatment of primary tumor.

Tuberkuloz ve Toraks — Wed, 30 Sep 2009 14:18:03 +0100

We described a 56-year-old woman with EBM of oral fibrosarcoma with local recurrence 13 years after treatment of primary tumor. We conclude that the possibility of central airway metastasis should be kept in mind if patients with a past history of malignancy present with symptoms consistent with bronchial tumors, even if there are 13 years interval. Of several mechanisms EBM, we assume direct aspiration and implantation of tumor cells to bronchus from oral cancer. PMID: 19787473 [PubMed - in process] (Source: Tuberkuloz ve Toraks)

An uncommon case of T1b breast cancer with diabetic mastopathy in type II diabetes mellitus.

Breast Cancer — Tue, 29 Sep 2009 23:00:00 +0100

Authors: Yamashita M, Ogawa T, Hanamura N, Kashikura Y, Mitsui T, Zhang X, Fujii K, Shiraishi T A 64-year-old postmenopausal female had been treated with insulin therapy for type 2 diabetes mellitus for 18 years, but her diabetes mellitus was not well controlled and she developed retinopathy. Her screening mammography showed abnormal findings, and thus she consulted a hospital. A physical examination showed her mammary glands to be hard on both sides and no palpable mass was observed. Mammography revealed an amorphous calcification in the middle outer portion of the left breast. Ultrasonography showed an irregular hypoechoic mass measuring about 11 mm in size in the upper outer portion of the left breast. Although a core-needle biopsy specimen of the hypoechoic mass showed hyalinizing ...

Lipid-rich carcinoma of breast: A case report with fine needle aspiration cytology

Diagnostic Cytopathology — Tue, 29 Sep 2009 23:00:00 +0100

No abstract. (Source: Diagnostic Cytopathology)

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3.0-T MR-guided focused ultrasound for preoperative localization of nonpalpable breast lesions: An initial experimental ex vivo study

Journal of Magnetic Resonance Imaging — Sun, 27 Sep 2009 23:00:00 +0100

To compare the accuracy of magnetic resonance-guided focused ultrasound (MRgFUS) with MR-guided needle-wire placement (MRgNW) for the preoperative localization of nonpalpable breast lesions.In this experimental ex vivo study, 15 turkey breasts were used. In each breast phantom an artificial nonpalpable "tumor" was created by injecting an aqueous gel containing gadolinium. MRgFUS (n = 7) was performed with the ExAblate 2000 system (InSightec). With MRgFUS the ablated tissue changes in color and increases in stiffness. A rim of palpable and visible ablations was created around the tumor to localize the tumor and facilitate excision. MRgNW (n = 8) was performed by MR-guided placement of an MR-compatible needle-wire centrally in the tumor. After surgical excision of the tumor, MR images were u...

The role of laboratory processing in determining diagnostic conclusiveness of breast fine needle aspirations: conventional smearing versus a monolayer preparation [Original articles]

Journal of Clinical Pathology — Fri, 25 Sep 2009 17:01:35 +0100

Conclusion: Patients presenting with breast lesions can more often be offered a same-day, conclusive cytopathological diagnosis when FNA are prepared by a manual MP processing technique. (Source: Journal of Clinical Pathology)

[Original articles] The role of laboratory processing in determining diagnostic conclusiveness of breast fine needle aspirations: conventional smearing versus a monolayer preparation

Journal of Clinical Pathology — Thu, 24 Sep 2009 23:00:00 +0100

The accuracy of frozen section analysis in ultrasound- guided core needle biopsy of breast lesions

BMC Cancer — Wed, 23 Sep 2009 23:00:00 +0100

Conclusions: The frozen section analysis of suspect breast lesions performed by CNB displays good sensitivity/specificity characteristics. Immediate investigations of CNB is an accurate diagnostic tool and an important step in reducing psychological strain by minimizing the period of uncertainty in patients with breast tumor. (Source: BMC Cancer)

BI-RADS Lesion Characteristics Predict Likelihood of Malignancy in Breast MRI for Masses But Not for Nonmasslike Enhancement

American Journal of Roentgenology — Sun, 20 Sep 2009 23:00:00 +0100

CONCLUSION. Combinations of BI-RADS lesion descriptors can predict the probability of malignancy for breast MRI masses but not for NMLE. If our model is validated, masses with a low probability of malignancy may be eligible for short-interval follow-up rather than biopsy. Further research focused on predictive features of NMLE is needed. (Source: American Journal of Roentgenology)

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Clinical feasibility of microscopically-guided breast needle biopsy using a fiber-optic probe with computer-aided detection.

Technology in Cancer Research and Treatment — Fri, 18 Sep 2009 19:08:31 +0100

This study yielded tissue classifications based on measurement of optical refractive index and scattering. Confidence-rating schemes yielded combined sensitivity of 89% (16/18) and specificity of 78% (31/40). Refractive index tests alone identified tumor tissue with a sensitivity of 83% (15/18) and specificity of 75% (30/40). Scattering profiles independently identified tumor tissue with a sensitivity of 61% (11/18) and specificity of 60% (24/40). These results show that a biopsy needle with an integrated fiber optic probe can be used to identify breast tumor tissue for sampling. Integration of this probe into current practices offers the potential to reduce nondiagnostic sampling rates by directly evaluating in situ microscopic tissue properties in real-time, before removal. PMID: 197...

Utility of fine-needle aspiration as a diagnostic technique in breast lumps

Diagnostic Cytopathology — Tue, 15 Sep 2009 23:00:00 +0100

Fine-needle aspiration cytology (FNAC) is a simple, accurate, and safe procedure for the diagnosis of palpable breast lumps. The purpose of this study is to emphasis the utilization of FNAC in the Sudan and to evaluate our experience to identify the types of various breast lesions. A one year descriptive longitudinal study was conducted in Khartoum, Sudan. We obtained information (patient's personal data) and Fine-Needle Aspiration (FNA) samples, for 200 patients with palpable breast lesions. Subsequent tissue biopsies were taken from 131 patients of the 200 studied patients. Data were analyzed using a computer's SPSS program. Pearson chi-square test was used for statistical analyses. The diagnoses of the 200 breast FNAs were as follows: 61 (30.5%) were malignant, 5 (2.5%) were suspicious,...

The use of core biopsy imprint cytology in the ‘one-stop’ breast clinic

European Journal of Surgical Oncology — Mon, 14 Sep 2009 16:13:06 +0100

Conclusion: Core Biopsy Imprint Cytology is a rapid, reliable and accurate technique which enhances the known benefits of automated core biopsy. It allows core biopsies to be used successfully in the ‘one-stop’ clinic setting and obviates the need to use Fine Needle Aspiration Cytology (FNAC).When CBIC is used, there is a reduction in diagnostic waiting time (over core biopsy on its own) and an increase in diagnostic performance (over FNAC).This translates to an improvement in the management of patients with breast cancer through the earlier availability of the diagnosis and fewer out-patient appointments. (Source: European Journal of Surgical Oncology)

Needle placement accuracy during stereotactic localization mammography

Clinical Radiology — Fri, 11 Sep 2009 17:18:46 +0100

Conclusions: When problems are encountered in making an accurate registration of the lesion on the stereoradiographs, consider the following error reducing strategies: (1) employ an approach that places the lesion the maximum distance away from the film cassette; (2) avoid reducing the angle of tube swing; and (3) consider sampling superficial and deep to, as well as at, the location indicated. The possibility of erroneous tissue sampling should be borne in mind when reviewing the pathology report. (Source: Clinical Radiology)