MedWorm: Breast Surgery

Ohio woman: U.S. doctor botched breast surgery

CTV Health — Mon, 15 Mar 2010 18:05:12 +0100

An Ohio woman claims in a lawsuit that a Pennsylvania plastic surgeon used the wrong kind of breast implants on her, then kept her knocked out longer than necessary and continued with the botched operation on the advice of her fiance. (Source: CTV Health)

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Evaluation of protein pigment epithelium-derived factor (PEDF) and microvessel density (MVD) as prognostic indicators in breast cancer

Journal of Cancer Research and Clinical Oncology — Sun, 14 Mar 2010 11:26:22 +0100

Conclusion The inverse correlation between PEDF expression and MVD in human breast cancer suggests that low PEDF expression is associated with angiogenesis in breast cancer. PEDF expression is therefore a potentially useful prognostic marker for breast cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0830-yAuthors Dan Zhou, Harbin Medical University Department of Breast Surgery, Tumor Hospital 158 HaPing Road Harbin 150081 ChinaShao-Qiang Cheng, Harbin Medical University Department of Breast Surgery, Tumor Hospital 158 HaPing Road Harbin 150081 ChinaHong-Fei Ji, Institute of Tumor Research of Harbin Medical University Harbin ChinaJin-Song Wang, Harbin Medical University Department of Breast Surgery, Tumor Hospital 158 HaPing Road Harb...

[Patent blue V : Inert dye or potent allergen?]

Der Anaesthesist — Sat, 13 Mar 2010 00:00:00 +0100

Authors: Rogler V, Röhm C, Reutershan J Patent blue V is widely used as a food dye. Clinically, patent blue V dye has been increasingly used in oncological surgery to identify the sentinel lymph nodes in breast cancer and other malignancies. The case of a patient who developed severe anaphylactic shock to subcutaneous injection of patent blue V during breast surgery is presented. The clinical course and the anesthesiological management are presented, and the pitfalls that may delay the correct diagnosis are highlighted. PMID: 20224949 [PubMed - as supplied by publisher] (Source: Der Anaesthesist)

The roles of toll-like receptors in carcinogenesis and cancer immunotherapy

The Chinese-German Journal of Clinical Oncology — Thu, 11 Mar 2010 04:14:39 +0100

Abstract Toll-like receptors (TLRs) are probably the most important class of pattern-recognition receptors. Members of the TLR family play key roles in the both innate and adaptive immune responses. Recognition of pathogen-associated molecular patterns (PAMPs) by TLRs, either alone or in heterodimerization with other TLR or non-TLR receptors, induces the production of signals that are responsible for the activation of genes important for an effective host defense, especially those of proinflammatory cytokines. Thus, TLRs are involved in the development of many pathological conditions including infectious diseases, tissue damage, and cancer especially. In this review, the contribution of TLRs to tumorgenesis is evaluated. We hope to provide new insight into the progression ...

Is there a Role for MRI in the Preoperative Assessment of Patients with DCIS?

Annals of Surgical Oncology — Wed, 10 Mar 2010 16:00:55 +0100

Conclusions MRI does not accurately predict extent of disease in patients with extensive DCIS. In patients with MRI tumor size ≤2 cm, MRI may assist in surgical planning. MRI results in patients with DCIS should be interpreted with caution; decision for mastectomy should not be made on MRI findings alone. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-010-1000-9Authors Lisa R. Allen, Drexel University College of Medicine Department of Surgery Philadelphia PA USAClaudia E. Lago-Toro, The Bryn Mawr Hospital Department of Breast Surgery Bryn Mawr PA USAJenevieve H. Hughes, The Bryn Mawr Hospital Department of Breast Surgery Bryn Mawr PA USAEduardo Careaga, The Bryn Mawr Hospital Department of Breast Surgery Bryn Mawr PA USAAnjeanette T. B...

Need for a Different Strategy for Breast Cancer Screening in India: Reply to Letter

World Journal of Surgery — Wed, 10 Mar 2010 15:57:19 +0100

Content Type Journal ArticleDOI 10.1007/s00268-010-0510-8Authors Gaurav Agarwal, Sanjay Gandhi Postgraduate Institute of Medical Sciences Department of Endocrine and Breast Surgery Raebareli Road Lucknow 226014 IndiaPooja Ramakant, Sanjay Gandhi Postgraduate Institute of Medical Sciences Department of Endocrine and Breast Surgery Raebareli Road Lucknow 226014 India Journal World Journal of SurgeryOnline ISSN 1432-2323Print ISSN 0364-2313 (Source: World Journal of Surgery)

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Dispatch: 9/11 Distorted, Breast Surgery Sought, Herbicide Vilified

Health Facts and Fears — Tue, 09 Mar 2010 05:00:00 +0100

ACSH& rsquo;s Jeff Stier wrote an article for the Daily Caller warning about the upcoming trial in which exaggerated health claims may extract money from funds set aside for those claiming to be suffering from conditions related to the World Trade Center wreckage ... (Source: Health Facts and Fears)

Graphic medicine: use of comics in medical education and patient care

BMJ Online First — Wed, 03 Mar 2010 12:15:03 +0100

(Source: BMJ Online First)

American Society of Clinical Oncology-recommended surveillance and physician specialty among long-term breast cancer survivors

Cancer — Tue, 02 Mar 2010 00:00:00 +0100

It is unclear whether it is appropriate to transfer the follow-up care of breast cancer (BrCa) survivors from cancer specialists to primary care physicians (PCPs). This contemporary study compared physician specialty and documented the long-term surveillance of survivors who underwent surgery at an American academic center.Women in this institutional review board-approved study underwent breast surgery between 1996 and 2006. Data were collected for 270 patients with stage I to III BrCa (mean follow-up, 6 years). Charts were reviewed based on American Society of Clinical Oncology (ASCO) guidelines for recommended surveillance frequency and care.The majority of patients (90%; n = 242) were followed by specialists with 10% (n = 28) followed by PCPs. Patients with advanced disease and a greate...

Arm port implantation in cancer patients

International Journal of Clinical Oncology — Mon, 01 Mar 2010 18:08:44 +0100

Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10147-010-0041-1Authors Pierre-Yves Marcy, Sophia Antipolis University Interventional Radiology Department, Antoine Lacassagne Cancer Research Institute 33 Avenue Valombrose 06189 Nice Cedex 1 FranceAndrea Figl, Sophia Antipolis University Department of Breast Surgery, Antoine Lacassagne Cancer Research Institute 33 Avenue Valombrose 06189 Nice Cedex 1 FranceNicolas Amoretti, Sophia Antipolis University Interventional Radiology Department, Antoine Lacassagne Cancer Research Institute 33 Avenue Valombrose 06189 Nice Cedex 1 FranceAntoine Ianessi, Sophia Antipolis University Interventional Radiology Department, Antoine Lacassagne Cancer Research Institute 33 Avenue Valombrose 06189 Nice Cedex 1 France Journal In...

Income, productivity, and satisfaction of breast surgeons

American Journal of Surgery — Mon, 01 Mar 2010 00:00:00 +0100

Conclusions: Although cause and effect relationships between income and breast surgery are difficult to establish, several trends do emerge. Most significantly, we found that dedicated breast surgeons have higher job satisfaction ratings and similar income satisfaction despite lower incomes. (Source: American Journal of Surgery)

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Choice of Management of Southern Chinese BRCA Mutation Carriers

World Journal of Surgery — Thu, 25 Feb 2010 06:49:16 +0100

Conclusions Chinese BRCA mutation carriers have a higher uptake of cancer surveillance than prophylactic surgery and have a lack of interest in the use of chemoprevention drugs. Content Type Journal ArticleDOI 10.1007/s00268-010-0477-5Authors Ava Kwong, The University of Hong Kong Li Ka Shing Faculty of Medicine Division of Breast Surgery Hong Kong Hong KongConnie H. N. Wong, The University of Hong Kong Li Ka Shing Faculty of Medicine Division of Breast Surgery Hong Kong Hong KongCatherine Shea, The University of Hong Kong Li Ka Shing Faculty of Medicine Division of Breast Surgery Hong Kong Hong KongDacita T. K. Suen, The University of Hong Kong Li Ka Shing Faculty of Medicine Division of Breast Surgery Hong Kong Hong KongCatherine L. Y. Choi, The University of Hong ...

[Why do women refuse reconstructive breast surgery after mastectomy?]

Gynecologie, Obstetrique & Fertilite — Thu, 25 Feb 2010 00:00:00 +0100

Authors: Henry M, Baas C, Mathelin C The implementation of mammographic screening and neo-adjuvant therapeutics has profoundly modified breast cancer surgery, making it less aggressive. Despite these progresses, mastectomies must be performed in more than 20% of breast cancer cases. Psychological disorders following mastectomy are numerous and lead to various alterations of self-esteem, femininity and sexuality. Reconstructive breast surgery proves to be beneficial to improve these psychological disorders in about 20% of women, who accept breast mourning and appropriate their reconstructed breast. However, 80% of the patients refuse reconstructive breast surgery. Our review aims at analysing different motivations explaining reconstructive breast surgery refusal and different ways of "r...

Association of shared decision-making with type of breast cancer surgery: a cross-sectional study

BMC Health Services Research — Tue, 23 Feb 2010 00:00:00 +0100

Conclusion: Our population-based study suggested that women's treatment decisions might be shaped by the information provided by physicians, and that women might request different information from their physicians based on their preferred treatment options. These results might need to be confirmed in other studies of treatment decisions. (Source: BMC Health Services Research)

Skin-Sparing Mastectomy and Immediate Breast Reconstruction in the Management of Locally Recurrent Breast Cancer

Annals of Surgical Oncology — Fri, 12 Feb 2010 07:20:53 +0100

Conclusion IBR is a possible treatment option for patients who develop local recurrence following earlier BCT. Our local re-recurrence rate of 10% compares well with that following salvage mastectomy for IBTR. Of patients, 43% did not actually meet our selection criteria but yet appeared to fare well in terms of outcome. Therefore we should re-evaluate our selection criteria. Content Type Journal ArticleCategory Reconstructive OncologyDOI 10.1245/s10434-010-0957-8Authors A. J. Lindford, Helsinki University Central Hospital Department of Plastic Surgery and Breast Surgery Unit Helsinki FinlandT. J. Meretoja, Helsinki University Central Hospital Department of Plastic Surgery and Breast Surgery Unit Helsinki FinlandK. A. J. von Smitten, Helsinki University Central Hospit...

Increased estrogen sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1(17β-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients

Breast Cancer Research and Treatment — Fri, 12 Feb 2010 07:12:02 +0100

Abstract Aromatase inhibitors (AIs) are considered the gold standard for endocrine therapy of estrogen receptor (ER) positive postmenopausal breast cancer patients. The therapy may enhance therapeutic response and stabilize disease but resistance and disease progression inevitably occur in the patients. These are considered at least partly due to an emergence of alternative intratumoral estrogen production pathways. Therefore, in this study we evaluated effects of exemestane (EXE) upon the enzymes involved in intratumoral estrogen production including estrogen sulfatase (STS), 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), and estrogen sulfotransferase (EST) and correlated the findings with therapeutic responses including Ki67 labeling index (Ki67). 116 postmenopausa...

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Ways To Help Your Girlfriend with Breast Cancer

About.com Breast Cancer — Fri, 12 Feb 2010 00:00:00 +0100

Treat Her Like A PrincessPhoto ©Bright Sky Press Denise Hazen was diagnosed with Stage 3 breast cancer, and made a decision to stay positive. She even got in front a CNN camera for the documentary "Taming the Beast," made at M.D. Anderson Cancer Center. Denise got through seventeen chemo treatments, a double mastectomy and six weeks of external breast radiation. You get the idea - she's a true survivor. Nowdays she volunteers with the Pink Ribbons Project in Houston, Texas and has written a book about her experience. But the book isn't just a breast cancer memoir. Treat Her Like a Princess: How to Help Your Girlfriend with Breast Cancer is full of practical advice for patients and supporters. Life doesn't come to a stop while you go through treatment, so you may need her tips on meal pl...

Changes in Circulating Tumor Cell Detection in Patients with Localized Breast Cancer Before and After Surgery

Annals of Surgical Oncology — Fri, 05 Feb 2010 08:03:10 +0100

Conclusions This study provides evidence of the presence of CTCs in approximately 30% of patients with localized breast cancer both before and after surgery, with change from positive to negative and vice versa in 40% of cases. No association with the pathological variables was found, except for vascular invasion and presence of preoperative CTCs. Long-term follow-up will be required to understand the significance of these data. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-010-0918-2Authors Maria T. Sandri, European Institute of Oncology Unit of Laboratory Medicine Via Ripamonti 435 Milan ItalyLaura Zorzino, European Institute of Oncology Unit of Laboratory Medicine Via Ripamonti 435 Milan ItalyMaria C. Cassatella, European Institute of Onco...

XRCC2 Arg188His polymorphism is not directly associated with breast cancer risk: evidence from 37,369 subjects

Breast Cancer Research and Treatment — Mon, 01 Feb 2010 18:07:12 +0100

Abstract Several common single-nucleotide polymorphisms (SNPs) within the XRCC2 gene have been identified as potential breast cancer susceptibility loci and a coding SNP in exon 3 (Arg188His, rs3218536) has been extensively studied, though the results were inconclusive. We, in this study, performed a more convincing and precise estimation of the relationship between Arg188His and breast cancer by meta-analyzing the currently available evidence from literature. A total of 16 studies involving 18,341 cases and 19,028 controls (37,369 subjects) were identified for meta-analysis. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the codominant model, dominant model, and recessive model. When all the studies were pool...

Pathologic Complete Response to Preoperative Sequential Doxorubicin/Cyclophosphamide and Single-Agent Taxane With or Without Trastuzumab in Stage II/III HER2-Positive Breast Cancer.

Clinical Genitourinary Cancer — Mon, 01 Feb 2010 00:00:00 +0100

Conclusion: Sequential administration of preoperative doxorubicin and cyclophosphamide followed by a taxane and trastuzumab combination is safe in women with primary operable HER2+ breast cancer and is associated with a high pCR rate. Large randomized phase III clinical trials are evaluating the role of preoperative trastuzumab when added to anthracycline- and/or taxane-based regimens. PMID: 20133257 [PubMed - in process] (Source: Clinical Genitourinary Cancer)

Mediators of a brief hypnosis intervention to control side effects in breast surgery patients: Response expectancies and emotional distress.

Journal of Consulting and Clinical Psychology — Tue, 26 Jan 2010 15:18:03 +0100

Conclusions: The results demonstrate the mediational roles of response expectancies and emotional distress in clinical benefits associated with a hypnotic intervention for breast cancer surgical patients. More broadly, the results improve understanding of the underlying mechanisms responsible for hypnotic phenomena and suggest that future hypnotic interventions target patient expectancies and distress to improve postsurgical recovery. (PsycINFO Database Record (c) 2009 APA, all rights reserved) (Source: Journal of Consulting and Clinical Psychology)

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Feasibility of sentinel lymph node biopsy in multiple unilateral synchronous breast cancer: results of a French prospective multi-institutional study (IGASSU 0502).

Ann Oncol — Wed, 20 Jan 2010 00:00:00 +0100

CONCLUSION: With a FNR of 13.6%, we do not recommend SLNB as a routine procedure for MST, even for small tumor. PMID: 20089557 [PubMed - as supplied by publisher] (Source: Ann Oncol)

Reflexology improves post-breast surgery quality of life

MedWire News - Oncology — Tue, 19 Jan 2010 13:50:09 +0100

Reflexology and massage have significant positive effects on the quality of life of women who have undergone surgery for early breast cancer, UK researchers report. (Source: MedWire News - Oncology)

Reflexology improves post-breast surgery quality of life

MedWire News - Breast Cancer — Mon, 18 Jan 2010 00:00:00 +0100

Reflexology and massage have significant positive effects on the quality of life of women who have undergone surgery for early breast cancer, UK researchers report. (Source: MedWire News - Breast Cancer)

Early physiotherapy reduces breast surgery complications

MedWire News - Breast Cancer — Sat, 16 Jan 2010 13:47:32 +0100

Early physiotherapy, including massage and shoulder exercises, could help to prevent and reduce secondary lymphedema after breast surgery, study findings indicate. (Source: MedWire News - Breast Cancer)

Early physiotherapy reduces breast surgery complications

MedWire News - Oncology — Sat, 16 Jan 2010 13:47:32 +0100

Early physiotherapy, including massage and shoulder exercises, could help to prevent and reduce secondary lymphedema after breast surgery, study findings indicate. (Source: MedWire News - Oncology)

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No association between a progesterone receptor gene promoter polymorphism (+331G>A) and breast cancer risk in Caucasian women: evidence from a literature-based meta-analysis

Breast Cancer Research and Treatment — Fri, 15 Jan 2010 00:44:25 +0100

In conclusion, the present meta-analysis strongly suggests that +331G>A in the PgR gene is not associated with breast cancer risk. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-010-0738-xAuthors Ke-Da Yu, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute 399 Ling-Ling Road 200032 Shanghai People’s Republic of ChinaAo-Xiang Chen, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute 399 Ling-Ling Road 200032 Shanghai People’s Republic of ChinaZhi-Ming Shao, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute 399 Ling-Ling Road 200032 Shanghai People’s Republic of China Journal Breast Cancer Research and TreatmentOnline ISSN 1573-7217Print ISSN 0167-6806 (Source: Br...

BMJ Group Lifetime Achievement Award

BMJ Online First — Thu, 14 Jan 2010 16:57:28 +0100

(Source: BMJ Online First)

Preoperative MRI fails to reduce risk of incomplete tumour excision in small breast cancers

BMJ Online First — Wed, 13 Jan 2010 13:09:14 +0100

(Source: BMJ Online First)

Physiotherapy cuts complications after breast surgery

OnMedica Latest News — Wed, 13 Jan 2010 00:00:00 +0100

Secondary lymphedema risk reduced after physiotherapyRelated items from OnMedicaResearchers find clues to breast cancer survival Breast cancer diagnosis often delayed in young women Risk assesment for breast cancer should begin earlier Chemo plus tamoxifen better than tamoxifen alone Exercise and good diet helps slow cell-aging process (Source: OnMedica Latest News)

Paper round: Wednesday

OnMedica Latest News — Wed, 13 Jan 2010 00:00:00 +0100

WHO reassesses swine flu pandemic, the positives of negativity, and moreRelated items from OnMedicaGovernment backs plan to stop children using sunbedsBlood pressure drugs may reduce risk of dementiaVitamin D and calcium supplements reduce fracture risk Future healthPhysiotherapy cuts complications after breast surgery (Source: OnMedica Latest News)

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Excaliard Initiates Phase 2 Trials In U.S. For Its Skin Scarring Drug, EXC 001

Health News from Medical News Today — Wed, 06 Jan 2010 10:00:00 +0100

Excaliard Pharmaceuticals, Inc. announced the initiation of three proof of concept Phase 2 trials of EXC 001, an antisense medicine that reduces fibrosis, for the amelioration of skin scarring and other fibrotic disorders. The U.S. multicenter trials will test the efficacy, safety, and tolerability of EXC 001 in two different models to evaluate the improvement of the appearance of scars in subjects undergoing elective abdominoplasty surgery and revision of scars associated with prior breast surgery... (Source: Health News from Medical News Today)

A simple aid to wire localisation procedure in breast surgery: 'covering the hook-wire with a needle'.

Annals of the Royal College of Surgeons of England — Fri, 01 Jan 2010 00:00:00 +0100

Authors: Ray K, Chouhan A, Johri A PMID: 20063447 [PubMed - in process] (Source: Annals of the Royal College of Surgeons of England)

Skin-Reducing Subcutaneous Mastectomy Using a Dermal Barrier Flap and Immediate Breast Reconstruction with an Implant: A New Surgical Design for Reconstruction of Early-Stage Breast Cancer

Aesthetic Plastic Surgery — Thu, 31 Dec 2009 07:28:55 +0100

Conclusions The authors present their early results with SRSM using the dermal barrier flap and silicone implants for early-stage breast cancer. The dermal barrier flap became a reliable procedure by providing a decreased breast envelope, eliminating the risk of implant exposure, and forming a double layer of dermal tissue at the incision line. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00266-009-9452-7Authors Yalcin Bayram, Bursa Military Hospital Department of Plastic and Reconstructive Surgery Bursa TurkeyYalcin Kulahci, Haydarpasa Training Hospital Department of Plastic and Reconstructive Surgery, Gulhane Military Medical Academy and Medical Faculty Selimiye Mah. Tıbbiye Cad., Kadikoy 34668 Istanbul TurkeyCeyhun Irgil, Bursa Breast Surgery ...

Lack of an association between a functional polymorphism in the interleukin-6 gene promoter and breast cancer risk: a meta-analysis involving 25,703 subjects

Breast Cancer Research and Treatment — Wed, 30 Dec 2009 16:46:15 +0100

Abstract The association between a single-nucleotide polymorphism (SNP) −174G > C (rs1800795) located in the IL-6 gene promoter and breast cancer risk is still controversial and ambiguous. We performed in this study a more precise estimation of the relationship by meta-analyzing the currently available evidence from literature. A total of 11 publications containing 12 studies including 10,137 cases and 15,566 controls were identified. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the codominant model, dominant model, and recessive model. When all the studies were pooled into the meta-analysis, there was no evidence showing a significant association between −174G > C and breas...

Professor Michael Baum

BMJ Online First — Wed, 30 Dec 2009 00:06:34 +0100

(Source: BMJ Online First)

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Breast Cancer Surgery Can Sometimes Cause Chronic, Persistent Pain

Breast Cancer Chronicles — Tue, 29 Dec 2009 04:04:00 +0100

It isn't something that women talk much about, nor does the breast surgeon inquire about it once the patient is several months beyond her breast-surgery date. The fact is, however, a fair number of women experience pain in their breast/chest area following breast surgery. (Source: Breast Cancer Chronicles)

Post-treatment pain remains clinically significant in breast cancer patients

Cancer Network — Mon, 28 Dec 2009 12:00:00 +0100

Many women continue to experience pain and sensory disturbance up to three years after breast cancer treatment, according to Danish researchers, who found that younger women in particular reported persistent pain. They called for further strategies for improving pain management after breast surgery. (Source: Cancer Network)

UHRF1 inhibits MDR1 gene transcription and sensitizes breast cancer cells to anticancer drugs

Breast Cancer Research and Treatment — Sat, 26 Dec 2009 16:39:11 +0100

Abstract Overexpression of MDR1 in breast cancer remains a major cause for the failure of chemotherapy. In the present report, we find UHRF1 plays an important role in inhibiting MDR1 promoter activity by directly binding to the MDR1 promoter. Knockdown of UHRF1 activates MDR1 promoter activity and expression, attenuates the binding of UHRF1 and HDAC1 to the MDR1 promoter. Overexpression of UHRF1 in NCI/ADR-RES cells can induce deacetylation of histones H3 and H4 on the MDR1 promoter, which is facilitated by recruitment of HDAC1 to the MDR1 promoter. Loss of histone acetylation is accompanied by loss of binding of the key transcription factor, MyoD, CBP and p300, locking in marked suppression of MDR1, increasing sensitivity of MDR cancer cells to cytotoxic drugs that are trans...

Impact of breast surgery on survival in patients with distant metastases at initial presentation: a systematic review of the literature

Breast Cancer Research and Treatment — Sun, 13 Dec 2009 06:42:45 +0100

Abstract According to current treatment standards, patients with metastatic breast cancer at diagnosis receive palliative therapy. Local treatment of the breast is only recommended if the primary tumor is symptomatic. Recent studies suggest that surgical removal of the primary tumor has a favorable impact on the prognosis of patients with primary metastatic breast cancer. We performed a systematic review of the literature to weigh the evidence for and against breast surgery in this patient group. Ten retrospective studies were found in which the use of breast surgery in primary metastatic breast cancer and its impact on survival was examined. The hazard ratios of the studies were pooled to provide an estimate of the overall effect of surgery, and the results and conclusion...

No more breast enlargement for girls under 18, Italian government orders

Telegraph Health — Sat, 12 Dec 2009 14:54:37 +0100

Italy is to introduce legislation that will make it illegal for girls under 18 to have breast enhancement or other plastic surgery. (Source: Telegraph Health)

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[Surgical treatment of breast cancer - 2009.]

Orvosi Hetilap — Wed, 09 Dec 2009 00:00:00 +0100

Authors: Lázár G The oncological surgery of the breast has changed in several aspects in the last two decades. The reasons are, first of all, the so-called biological approach to curing, cancer screening, the development of surgical technique and the daily use of quality assurance principles. We witness a paradigm-change again, and the essence of it is that the maximally radical treatment is replaced by the conception of a minimal but sufficient surgical treatment. Instead of being down-graded, surgery as a profession is more and more appreciated and remains still determinant in the treatment of breast cancer. PMID: 19995692 [PubMed - in process] (Source: Orvosi Hetilap)

UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer

Breast Cancer Research and Treatment — Fri, 27 Nov 2009 07:06:11 +0100

Abstract BRCA1 is closely related to the pathogenesis of breast cancer, BRCA1 mRNA is reduced in sporadic breast cancer cells despite the lack of mutations. In the present report, we found that overexpression of UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) was closely related to DNA methylation, deacetylation, and methylation of histones, recruitment of an inhibiting transcriptional complex on the BRCA1 promoter in sporadic breast cancer. Overexpression of UHRF1 induced deacetylation of histones H3 and H4, which was facilitated by recruitment of histone deacetylase1 (HDAC1) to the BRCA1 promoter. Loss of acetylation was accompanied by loss of binding of the key transcription factors MyoD, CBP, and p300. UHRF1 also recruited histone lysine methyltransfer...

Predicting the Risk of Axillary Nodal Metastases and Their Use in Selecting Breast Surgery Options [EDITORIALS]

Journal of Clinical Oncology — Wed, 25 Nov 2009 23:02:08 +0100

(Source: Journal of Clinical Oncology)

Use of the Harmonic Scalpel for Breast Surgery in Patients with a Cardiac Pacemaker – A Tip

The Breast Journal — Tue, 24 Nov 2009 00:00:00 +0100

(Source: The Breast Journal)

Breast Reconstruction with Implants, Tissue Expanders and AlloDerm: Predicting Volume and Maximizing the Skin Envelope in Skin Sparing Mastectomies

The Breast Journal — Thu, 19 Nov 2009 00:00:00 +0100

Abstract: AlloDerm has been used as a tissue supplement in conjunction with the pectoralis major muscle to provide full coverage over an implant in breast reconstruction. While this method of reconstruction has shown promising results there is little known on the relationship of AlloDerm size and potential immediate expansion volume. A retrospective chart review was completed evaluating all tissue expander or primary implant reconstructions using AlloDerm. Data recorded included: The type/size of implant/expander, dimensions of the AlloDerm used, initial fill volume, number of expansions and time period of expansion. Statistical analysis was completed with a linear regression model. AlloDerm was used on 49 patients (72 reconstructions). Thirty-four patients (50 reconstructions) underwent r...

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Case report: Pyoderma gangrenosum following Deep Inferior Epigastric Perforator (Diep) free flap breast reconstruction

Journal of Plastic, Reconstructive & Aesthetic Surgery — Thu, 19 Nov 2009 00:00:00 +0100

Summary: Pyoderma gangrenosum is a rare but significant cutaneous disease that can lead to skin ulceration and necrosis. It is idiopathic but can occur post surgically. There has been only a limited number of case reports of PG complicating breast surgery. (Source: Journal of Plastic, Reconstructive & Aesthetic Surgery)

One in Three Cancers Diagnosed with Free Mammogram Screening Is an "Overdiagnosis"

NaturalNews.com — Wed, 18 Nov 2009 07:00:00 +0100

(NaturalNews) In countries with public breast cancer screening programs, one in every three diagnosed with invasive breast cancers would never have produced symptoms in a patient before she died of other causes, a new study has revealed."Screening for cancer may lead to earlier detection of lethal cancers but also detects harmless ones that will not cause death or symptoms," wrote the researchers, from the Nordic Cochrane Center in Denmark, in the British Medical Journal."The detection of such cancers, which would not have been identified clinically in someone's remaining lifetime, is called overdiagnosis and can only be harmful to those who experience it."Researchers analyzed breast cancer diagnosis rates among both screened unscreened women in Australia, Canada, Norway, Sweden and the Un...

[The training of a resident in breast surgery.]

Cirugia eEspanola — Mon, 16 Nov 2009 00:00:00 +0100

Authors: Fuerte Ruiz S Breast surgery training of residents varies greatly in Spain and depends on the specialty chosen and the centre where this is carried out. Training programmes have been changing and have been updated within the current trend for subspecialisation. The results from a survey show that, for residents, training in breast surgery is not very attractive as they think that they do not receive adequate training. PMID: 19922908 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)

A randomised, controlled trial of the psychological effects of reflexology in early breast cancer

European Journal of Cancer — Wed, 11 Nov 2009 00:00:00 +0100

Conclusions: When compared to SIS, reflexology and massage have statistically significant, and, for reflexology, clinically worthwhile, effects on QofL following surgery for early breast carcinoma. (Source: European Journal of Cancer)

Pain often persists years after breast surgery

Reuters: Health — Tue, 10 Nov 2009 22:26:31 +0100

NEW YORK (Reuters Health) - In a study of Danish women who had surgery for breast cancer, nearly half still reported pain 2 to 3 years later, according to a report in this week's Journal of the American Medical Association. (Source: Reuters: Health)

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Chronic Pain Can Be a Problem Years After Breast Surgery

Modern Medicine — Tue, 10 Nov 2009 00:00:00 +0100

Despite breast-conserving surgery and other advances, post-breast surgery pain and sensory disturbances remained problems for many women in a Danish survey reported in the Nov. 11 issue of the Journal of the American Medical Association. (Source: Modern Medicine)

Obesity and Angiolymphatic Invasion in Primary Breast Cancer

Annals of Surgical Oncology — Sat, 07 Nov 2009 07:40:50 +0100

Discussion In this large sample of invasive breast cancers, obesity was independently associated with the presence of angiolymphatic invasion. Higher rates of angiolymphatic invasion among obese women may account in part for poorer outcomes among obese women with breast cancer. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-009-0797-6Authors Erin F. Gillespie, University of Michigan Medical School Ann Arbor MI USAMelony E. Sorbero, RAND Corporation Pittsburgh PA USADavid A. Hanauer, University of Michigan Comprehensive Cancer Center Department of Pediatrics, Bioinformatics Core Ann Arbor MI USAMichael S. Sabel, University of Michigan Comprehensive Cancer Center Department of General Surgery, Division of Surgical Oncology Ann Arbor MI USAEmily J...

Mother bled to death as doctor refused to leave bed

Scotsman.com News - Health — Sat, 07 Nov 2009 00:00:00 +0100

A MOTHER of two who bled to death hours after breast surgery would have had the best chance of survival if a consultant surgeon had agreed to leave his home to attend to her, (Source: Scotsman.com News - Health)

Breast op woman's death 'entirely preventable'

Scotsman.com News - Health — Fri, 06 Nov 2009 00:00:00 +0100

THE death of a 49-year old woman following breast surgery in Edinburgh's Western General Hospital was "entirely preventable". (Source: Scotsman.com News - Health)

Men’s Breast Obsession—And Women’s

Psychology Today Sex Center — Mon, 02 Nov 2009 19:17:24 +0100

In our culture, men are assumed to be obsessed with women's breasts. Men's obsession is reflected in the huge vocabulary men use when discussing them: tits, boobs, jugs, hooters, melons, globes, knobs, headlights, mammaries, ta-ta's, chest toys, fun bags, the girls, etc. In addition, ask any waitress: Low-cut tops with visible cleavage means better tips. Many women complain that in conversations with men, the guys look at their breasts, not at their faces. And then there's the old joke about a group of women who apply for a job. Some are highly qualified, others, less qualified. Who gets hired? The one with the biggest breasts.To feel attracted to a woman, some men need a certain breast size--large, medium, or small (just as some women need a certain height or body type in men). But most m...

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Thousands of women 'having unnecessary breast surgery'

the Mail online | Health — Mon, 02 Nov 2009 08:09:45 +0100

Guidance on breast cancer screening is being rewritten after a study found thousands of women were having unnecessary surgery. (Source: the Mail online | Health)

Use of the Acellular Dermal Matrix in Revisionary Aesthetic Breast Surgery

Aesthetic Surgery Journal — Sun, 01 Nov 2009 00:00:00 +0100

Conclusions: Revisionary augmentation and revision of augmentation mastopexy are commonly performed procedures and they have a significantly higher complication rate than primary procedures. This series shows that the ADM can be used both safely and effectively in revisionary cases, resulting in decreased rates of capsular contracture and implant cushioning/stabilization. (Source: Aesthetic Surgery Journal)

New Technologies for the Assessment of Breast Surgical Outcomes

Aesthetic Surgery Journal — Sun, 01 Nov 2009 00:00:00 +0100

Conclusions: The scanning methodology reported here reliably describes the breast surface not only in a static position, but also at specific postures or during motion of the body. It also opens the door for quantitative static and dynamic assessment of surgical outcomes, the intraoperative assessment of breast shape, and other applications. Limitations include the relatively long amount of time required for each scan and the need for technical and clinical validation, particularly with respect to four-dimensional assessment. (Source: Aesthetic Surgery Journal)

Grant To Study Breast Cancer Reconstruction Received By Clemson Researchers

Health News from Medical News Today — Fri, 30 Oct 2009 07:00:00 +0100

The Avon Foundation for Women has awarded the Clemson University Institute for Biological Interfaces of Engineering a $195,000 grant to support research to develop new ways to improve reconstructive breast surgery using engineered tissue that contains anti-cancer properties. (Source: Health News from Medical News Today)

Diagnostic performance of fluorodeoxyglucose-positron emission tomography/computed tomography of breast cancer in detecting axillary lymph node metastasis: comparison with ultrasonography and contrast-enhanced CT

Annals of Nuclear Medicine — Thu, 29 Oct 2009 19:48:22 +0100

Conclusions PET/CT showed poor sensitivity and high specificity in the detection of axillary lymph node metastasis of breast cancer. Diagnostic performance of PET/CT was not superior to that of ultrasonography and contrast-enhanced CT. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12149-009-0314-9Authors Shuichi Monzawa, Hyogo Cancer Center Department of Radiology Kitaohji 13-70 Akashi Hyogo 673-8558 JapanShuji Adachi, Hyogo Cancer Center Department of Radiology Kitaohji 13-70 Akashi Hyogo 673-8558 JapanKayo Suzuki, Hyogo Cancer Center Department of Radiology Kitaohji 13-70 Akashi Hyogo 673-8558 JapanKoichi Hirokaga, Hyogo Cancer Center Department of Breast Surgery and Oncology Kitaohji 13-70 Akashi Hyogo 673-8558 JapanShintaro Takao, Hyogo Cancer C...

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Clemson research receives grant to study breast cancer reconstruction

EurekAlert! - Medicine and Health — Wed, 28 Oct 2009 04:00:00 +0100

(Clemson University) The Avon Foundation for Women has awarded the Clemson University Institute for Biological Interfaces of Engineering a $195,000 grant to support research to develop new ways to improve reconstructive breast surgery using engineered tissue that contains anti-cancer properties. (Source: EurekAlert! - Medicine and Health)

[Contribution to the study of painful and functional sequellae after breast reconstruction using latissimus dorsi flap. Investigation into 149 patients.]

Annales de Chirurgie Plastique et Esthetique — Wed, 28 Oct 2009 00:00:00 +0100

Authors: Faucher A, Barrault M, Duguey I Latissimus dorsi flap is the most commonly used among tissues transfers for breast reconstruction. If its qualities and performances are well known, few papers have studied sequellae of this flap, particularly painful. The purpose of this paper is to provide a contribution about this subject. Postulating the complexity of this step, we limited ourselves initially to an evaluation based on analysis of concise questionnaire mailed to two pools of patients with different delays since their reconstruction using latissimus flap. In the two groups of patients, announced principal embarrassment - logically associated with a gestural limitation - is the feeling of axillo-dorsal rigidity, more pregnant than the pain itself. This one is marked during the ...

Postoperative impact of regular tobacco use, smoking or snuffing, a prospective multi-center study

Acta Anaesthesiologica Scandinavica — Mon, 26 Oct 2009 00:00:00 +0100

The aim was to study the effects of different tobacco administration routes on pain and post-operative nausea and vomiting (PONV), following three common day surgical procedures: cosmetic breast augmentation (CBA), inguinal hernia repair (IHR) and arthroscopic procedures (AS). We have prospectively investigated the effects of regular tobacco use in ambulatory surgery. The 355 allocated patients were followed during recovery and the first day at home. Thirty-two percent of the patients used tobacco regularly, 33% of CBA, 27% of IHR and 34% of AS. Pain was well controlled in the post-anesthesia care unit at rest; during ambulation, 37% of all patients reported VAS>3. Tobacco use had no impact on early post-operative pain. Post-operative nausea was experienced by 30% of patients during recove...

Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1

Breast Cancer Research and Treatment — Fri, 23 Oct 2009 18:44:04 +0100

In conclusion, SNPs/haplotypes in the GSTM3 gene within the GSTMs gene cluster are likely to contribute to breast cancer risk when the GSTM1 is absent. We infer that GSTM3 catalyzing ability in normal breast tissue might protect against breast carcinogenesis. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0585-9Authors Ke-Da Yu, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute, Breast Cancer Institute 399 Ling-Ling Road Shanghai 200032 ChinaLei Fan, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute, Breast Cancer Institute 399 Ling-Ling Road Shanghai 200032 ChinaGen-Hong Di, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute, Breast Cancer Institute 399 Ling-Ling Road Sha...

Communication during breast cancer treatment

BMJ Online First — Fri, 23 Oct 2009 12:10:30 +0100

(Source: BMJ Online First)

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Menin, a product of the MENI gene, binds to estrogen receptor to enhance its activity in breast cancer cells: possibility of a novel predictive factor for tamoxifen resistance

Breast Cancer Research and Treatment — Wed, 21 Oct 2009 19:48:16 +0100

Abstract Multiple coactivator and corepressor complexes play an important role in endocrine processes and breast cancer; in particular, estrogen and estrogen receptor-α (ERα) promote the proliferation of breast cancer cells. Menin is a tumor suppressor encoded by Men1 that is mutated in the human-inherited tumor syndrome multiple endocrine neoplasia type 1 (MEN1); it also serves as a critical link in the recruitment of nuclear receptor-mediated transcription. Here, we show that menin expressed in breast cancer cell line MCF-7 is colocalized with ERα and functions as a direct coactivator of ER-mediated transcription in breast cancer cells. In MCF-7 cells, coexpression of menin and estrogen-response element-luciferase induced the activity of the latter in a hormone-depende...

Utility of an upright-type 11-gauge stereotactic vacuum-assisted biopsy device (Mammotome®) for the diagnosis of breast microcalcifications

The Chinese-German Journal of Clinical Oncology — Wed, 21 Oct 2009 19:13:47 +0100

Conclusion The upright stereotactic 11-gauge Mammotome procedure is an effective and reliable method for the diagnosis of breast microcalcifications. It has minimal side effects. For lesions diagnosed as ADH or DCIS with the 11-gauge Mammotome, subsequent surgical excision should be performed. Content Type Journal ArticleDOI 10.1007/s10330-009-0100-0Authors Ming Yang, the First Hospital of Jilin University Department of Breast Surgery Changchun 130021 ChinaTakanori Ishida, Tohoku University School of Medicine Department of Surgical Oncology Sendai JapanMotohiro Takeda, Tohoku University School of Medicine Department of Surgical Oncology Sendai JapanNoriaki Ohuchi, Tohoku University School of Medicine Department of Surgical Oncology Sendai Japan Journal The Chin...

Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients

Breast Cancer Research and Treatment — Tue, 20 Oct 2009 16:19:14 +0100

Abstract Several adipocytokines, such as leptin or adiponectin, are associated with obesity and the risk for breast cancer. Adiopcyte fatty acid binding-protein (A-FABP) is another protein found in adipose tissue; therefore, we investigated the association of A-FABP with the occurrence and prognosis of breast cancer. In our study, 200 women attending the University of Ulm for breast surgery between the years 2005 and 2007 were included; 159 had histologically confirmed breast cancer; 41 had histologically confirmed benign lesions. Serum levels of A-FABP, leptin, and adiponectin were measured, and their relationship to body-mass-index (BMI), breast cancer, and tumor characteristics were analyzed; logistic regression model was adjusted to age, BMI, menopausal status, use of ...

Delayed surgery decreases survival in breast cancer patients with mammographic presentation

MedWire News - Oncology — Mon, 19 Oct 2009 00:00:00 +0100

An interval of more than 12 weeks from clinical presentation to breast surgery may be associated with decreased survival for breast cancer patients with a mammographic presentation, say researchers. (Source: MedWire News - Oncology)

Delayed surgery decreases survival in breast cancer patients with mammographic presentation

MedWire News - Breast Cancer — Mon, 19 Oct 2009 00:00:00 +0100

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Coding and revenue: impact on Portsmouth Breast Unit

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:47:06 +0100

Introduction: The Department of Health has introduced Payment by Results whereby Hospital Trusts charge Primary Care Trusts (PCTs) for work undertaken. This relies on accurate completion of spell summaries (TTOs) and coding to determine levels of reimbursement. This audit reviewed the breast surgery undertaken within the Portsmouth Breast Unit to assess whether tariffs charged were in line with actual work undertaken. (Source: European Journal of Surgical Oncology)

Oncoplastic breast surgery for cancer: the first 20 years

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:47:06 +0100

Introduction: For large tumours and those in less favourable locations, standard breast conserving therapy (BCT) is being replaced by more imaginative oncoplastic breast surgery (OBS) techniques that draw on plastic surgery principles to both anticipate and avoid poor aesthetic outcomes and further reduce the rate of mastectomy. (Source: European Journal of Surgical Oncology)

Are hospital trusts losing income by incomplete coding of operations? A review of complex breast surgery in a tertiary breast unit

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:47:05 +0100

This study aimed to assess the accuracy of data recorded about theatre activity and explore the financial implications of inaccurate coding. (Source: European Journal of Surgical Oncology)

Loco-regional and systemic recurrence rates following breast conserving surgery for breast cancer

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:47:04 +0100

This study aims to examine recurrence rates in breast cancer patients who underwent breast conserving surgery, to identify factors associated with recurrence and to compare locoregional recurrence rates to national guidelines issued by the Association of Breast Surgery at BASO, 2005. (Source: European Journal of Surgical Oncology)

Post operative analgesia for breast surgery: intercostal nerve block versus subcutaneous infiltration

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:47:01 +0100

Background: Post operative analgesia is often underestimated in breast surgery resulting in long term sequelae. Opiates and epidural analgesia may produce complications and limits early rehabilitation. We compare the analgesic effects of intercostal nerve block with subcutaneous infiltration in breast surgery. (Source: European Journal of Surgical Oncology)

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Surgical outcomes of using PIXARRAY 100 intra-operative X-ray machine (Bioptics, Daax integrated systems, UK) in breast surgery department - a prospective study

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:47:00 +0100

Introduction: Intra-operative specimen radiography is increasingly being used in breast surgery departments. These can be expensive and where departmental X-rays are easily available, may be considered an unnecessary luxury. The Cambridge Breast Unit deals with over 200 screen-detected cases per annum. Specimens for localisation X-rays are normally transported to the main department for assessment. We used the PIXARRAY 100 intra-operative X-ray machine (Bioptics, Daax integrated systems, UK) to evaluate whether the machine can contribute to our current practice, by saving time and improving operative outcomes. (Source: European Journal of Surgical Oncology)

Non use of drains in breast surgery

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:46:55 +0100

The use of drains in breast surgery is routine and is accepted to allow for healing of wounds without complications. The disadvantages of using drains after breast surgery include increased length of stay, discomfort, blockage and infection, extra clinic appointments, monitoring of outflow, patients inconvenience, increased nursing time, service implications and costs. Over the past years we changed our policy and have not used drains during breast operations. (Source: European Journal of Surgical Oncology)

Reconstructive surgical options in male breast cancer

European Journal of Surgical Oncology — Fri, 16 Oct 2009 12:46:55 +0100

Nearly 300 cases of male breast cancer are diagnosed annually in UK. The psychological impact of loss of nipple with conventional mastectomy in women is well known and has prompted increase in demand for reconstructive breast surgery. In men however, the removal of nipple during mastectomy is accepted as conventional treatment. This paper describes the surgical treatment undertaken in two men with emphasis on reconstruction. (Source: European Journal of Surgical Oncology)

Unilateral paravertebral block: an alternative to conventional spinal anaesthesia for inguinal hernia repair

Acta Anaesthesiologica Scandinavica — Wed, 14 Oct 2009 23:00:00 +0100

Inguinal herniorrhaphy can be successfully performed using general, regional or local anaesthesia. Paravertebral block (PVB) has been used for unilateral procedures such as thoracotomy, breast surgery, chest wall trauma, hernia repair or renal surgery. We compared unilateral lumbar PVB with conventional spinal anaesthesia (SA) in 60 consenting ASA I and II males aged 18[ndash]65 years, scheduled for unilateral inguinal hernia repair. Patients were randomly assigned into two groups, P (n=30) or S (n=30) to receive either PVB or SA, respectively. Two patients (7%) in group P had to be converted to general anaesthesia due to block failure. During surgery, patients of both groups received intravenous infusion of propofol titrated to light sedation. The time to first post-operative analgesic re...

Influence of Isolated Tumor Cells in Sentinel Nodes on Outcome in Small, Node-Negative (pT1N0M0) Breast Cancer

Annals of Surgical Oncology — Fri, 09 Oct 2009 06:13:27 +0100

Conclusions The findings suggest that presence of isolated tumor cells in the sentinel nodes is an adverse prognostic factor in early breast cancer, but its prognostic significance in association with standard factors may be limited. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-009-0723-yAuthors Marjut H. K. Leidenius, Helsinki University Central Hospital Breast Surgery Unit Helsinki FinlandJaana H. Vironen, Helsinki University Central Hospital Breast Surgery Unit Helsinki FinlandPäivi S. Heikkilä, Helsinki University Central Hospital Department of Pathology Helsinki FinlandHeikki Joensuu, Helsinki University Central Hospital Department of Oncology Helsinki Finland Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 106...

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Lack of better outcomes in breast surgery should not be traced to patients' tissue quality

Modern Medicine — Wed, 30 Sep 2009 23:00:00 +0100

Emphasis is ever-focused on long-term outcomes of various techniques and procedures. (Source: Modern Medicine)

Bacteriologic features of surgical site infections following breast surgery

American Journal of Surgery — Wed, 30 Sep 2009 23:00:00 +0100

Conclusions: Gram-negative SSIs constituted half of the SSIs in this breast surgery cohort. Of all breast isolates, 17.5% were resistant to cefazolin. On the basis of these findings, antibiotic prophylaxis regimens alternative to cefazolin should be considered. (Source: American Journal of Surgery)

What do breast surgeons do?

American Journal of Surgery — Wed, 30 Sep 2009 23:00:00 +0100

Conclusions: The specialty of breast surgery is unique in its nonoperative volume and extensive duration of follow-up. Strategies need to be designed to make this process more time-efficient for the surgeon. (Source: American Journal of Surgery)

Complications associated with postoperative antibiotic prophylaxis after breast surgery

American Journal of Surgery — Wed, 30 Sep 2009 23:00:00 +0100

Conclusions: Drug-related complications were uncommon with preoperative ABX prophylaxis. Considering the potential complications of ABX after breast surgery, the use of postoperative prophylaxis should be reexamined. (Source: American Journal of Surgery)

Nipple aspirate fluid and ductoscopy to detect breast cancer

Diagnostic Cytopathology — Tue, 29 Sep 2009 23:00:00 +0100

We prospectively performed cytologic assessment and image analysis (IA) on matched nipple aspirate fluid (NAF) and mammary ductoscopy (MD) specimens to determine (1) the accuracy of these methods in cancer detection and (2) whether the two collection methods provide complementary information.NAF and MD specimens were collected from 84 breasts from 75 women (nine bilateral samples) who underwent breast surgery. Cytologic evaluation was performed on all samples. IA was performed on slides with sufficient epithelial cells.Cytologic evaluation proved more accurate in patients without pathologic spontaneous nipple discharge (PND) than those with PND, mainly because of the potential false positive diagnosis in the latter. While the sensitivity of NAF and MD cytology was low (10% and 14%, respect...

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Family Sues After Teen's Breast Surgery Death

WDSU.com - Health — Thu, 24 Sep 2009 13:31:02 +0100

The family of cheerleader who died after corrective breast surgery files a lawsuit against a plastic surgeon and anesthesiologist. (Source: WDSU.com - Health)

Retromammary Approach for Endoscopic Resection of Benign Breast Lesions

World Journal of Surgery — Tue, 22 Sep 2009 15:40:38 +0100

Conclusions Video-assisted endoscopic breast surgery has changed routine breast surgery, manifesting cosmetic effects that cannot be achieved by previous routine surgical techniques. Patients with multiple or large benign tumors who desire excellent cosmetic results are good candidates for this approach. Content Type Journal ArticleDOI 10.1007/s00268-009-0225-xAuthors Hsien Liu, E-Da Hospital/I-Shou University Division of General Surgery Jaiu-Shu Tsuen, Yan-Chau Shiang Kaohsiung County Taiwan, Republic of ChinaChih-Kun Huang, E-Da Hospital/I-Shou University Division of General Surgery Jaiu-Shu Tsuen, Yan-Chau Shiang Kaohsiung County Taiwan, Republic of ChinaPo-Chin Yu, E-Da Hospital/I-Shou University Division of General Surgery Jaiu-Shu Tsuen, Yan-Chau Shiang Kaohsiun...

Intraoperative avidination for radionuclide treatment as a radiotherapy boost in breast cancer: results of a phase II study with 90Y-labeled biotin

European Journal of Nuclear Medicine and Molecular Imaging — Thu, 17 Sep 2009 11:55:28 +0100

Conclusions IART plus reduced EBRT can accelerate irradiation after conservative breast surgery. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1260-4Authors Giovanni Paganelli, European Institute of Oncology Division of Nuclear Medicine Via Ripamonti 435 20141 Milan ItalyConcetta De Cicco, European Institute of Oncology Division of Nuclear Medicine Via Ripamonti 435 20141 Milan ItalyMahila E. Ferrari, European Institute of Oncology Division of Medical Physics Via Ripamonti 435 Milan ItalyGiuseppe Carbone, European Institute of Oncology Division of Nuclear Medicine Via Ripamonti 435 20141 Milan ItalyGianmatteo Pagani, European Institute of Oncology Division of Senology Via Ripamonti 435 Milan ItalyMaria Cristina Leonardi, European Institute ...

Management of primary and advanced breast cancer in older unfit patients (medical treatment)

Cancer Treatment Reviews — Wed, 16 Sep 2009 23:00:00 +0100

Summary: Elderly women constitute a large group of breast cancer patients, and after multidimensional geriatric assessment (MGA) only a minor part of them are found in perfect health (=fit), while the remaining display one or more physical or functional limitations or familial/social problems and are therefore categorized as vulnerable or frail (=unfit). Although randomized trials have not produced modest evidence that surgery impacts on ultimate survival of elderly women with hormone-responsive tumors, there is a general consensus that age alone should not prevent surgical local treatment even in unfit women due to the limited morbidity of breast surgery and to the risk of local progression. Activity and safety of AIs appear comparable in elderly women compared to younger counterparts, al...

Motivations for Breast Surgery: A Qualitative Comparison Study of Breast Reconstruction, Augmentation, and Reduction Patients

The Breast Journal — Sun, 06 Sep 2009 23:00:00 +0100

(Source: The Breast Journal)

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Genetic contribution of GADD45A to susceptibility to sporadic and non-BRCA1/2 familial breast cancers: a systematic evaluation in Chinese populations

Breast Cancer Research and Treatment — Thu, 03 Sep 2009 06:18:45 +0100

In conclusion, although germline mutations of GADD45A is not common in familial breast cancer patients, polymorphisms/haplotypes in GADD45A contribute to breast cancer risk, at least to sporadic breast cancer. Content Type Journal ArticleCategory EpidemiologyDOI 10.1007/s10549-009-0516-9Authors Ke-Da Yu, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute, Breast Cancer Institute 399 Ling-Ling Road 200032 Shanghai People’s Republic of ChinaGen-Hong Di, Fudan University Department of Breast Surgery, Cancer Hospital/Cancer Institute, Breast Cancer Institute 399 Ling-Ling Road 200032 Shanghai People’s Republic of ChinaWen-Feng Li, The Affiliated Hospital of Qingdao University Medical College Department of Oncology Qingdao People’s Republic of ChinaNan-Ya...

Fat Injection to the Breast: Technique, Results, and Indications Based on 880 Procedures Over 10 Years

Aesthetic Surgery Journal — Mon, 31 Aug 2009 23:00:00 +0100

Conclusions: Lipomodeling, because of a low complication rate and positive results, presents a new option for plastic, reconstructive, and aesthetic surgery of the breast. Pre- and postoperative examination by a radiologist specialized in breast imaging is necessary to limit the risk that a cancer may occur coincidentally with lipomodeling. (Aesthet Surg J;29:360-378.) (Source: Aesthetic Surgery Journal)

Efficacy of Neopectoral Pocket in Revisionary Breast Surgery

Aesthetic Surgery Journal — Mon, 31 Aug 2009 23:00:00 +0100

Conclusions: The neopectoral pocket is a new type of site change operation. This procedure will address many of the issues seen today in revisionary aesthetic breast surgery for subpectoral implants that are already in place. These are frequently large implants that have displaced medially, inferomedially, inferiorly, or are encapsulated. (Aesthet Surg J;29: 379-385.) (Source: Aesthetic Surgery Journal)

The immunohistochemically “ER-negative, PR-negative, HER2-negative, CK5/6-negative, and HER1-negative” subgroup is not a surrogate for the normal-like subtype in breast cancer

Breast Cancer Research and Treatment — Fri, 28 Aug 2009 15:01:20 +0100

Abstract Breast cancer is a heterogeneous disease and can be subclassified into five major subtypes. The immunohistochemical (IHC) surrogates for four of the five subtypes have been developed by detection of ER, PR, HER2, HER1, and CK5/6 in breast cancers. To date, the IHC surrogate for the normal-like subtype is still ambiguous. However, some investigators treat the so-called “unclassified” IHC subgroup (negative for all the five markers) as the normal-like subtype. We have to understand that the normal-like subtype is absolutely different from the immunohistochemically “ER–, PR–, HER2–, CK5/6–, and HER1–” subgroup. Here, we show evidence to support the fact that low/negative expression of the basal-like markers is not the essence of the normal-like subt...

US-guided diffused optical tomography: a promising functional imaging technique in breast lesions

European Radiology — Wed, 26 Aug 2009 08:46:53 +0100

Conclusion US-guided diffused optical tomography, a noninvasive functional imaging technique, has potential utility in differentiating breast cancer from benign lesions. Content Type Journal ArticleCategory BreastDOI 10.1007/s00330-009-1551-yAuthors Shan-Shan You, Chinese Academy of Medical Sciences Department of Diagnostic Ultrasound, Peking Union Medical College Hospital No. 1 Shuaifuyuan Wangfujing Beijing 100730 ChinaYu-Xin Jiang, Chinese Academy of Medical Sciences Department of Diagnostic Ultrasound, Peking Union Medical College Hospital No. 1 Shuaifuyuan Wangfujing Beijing 100730 ChinaQing-Li Zhu, Chinese Academy of Medical Sciences Department of Diagnostic Ultrasound, Peking Union Medical College Hospital No. 1 Shuaifuyuan Wangfujing Beijing 100730 ChinaJi-Bin ...

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Arm Exercise HowTo

About.com Breast Cancer — Sun, 23 Aug 2009 23:00:00 +0100

This wand exercise helps with shoulder rotation. After breast surgery, your surgery-side shoulder may feel stiff, so exercise is an important way to increase your flexibility and extend your range of motion. You can use any household object for a wand while doing this exercise. Learn how to do the wand exercise for shoulder rotation here. (Source: About.com Breast Cancer)

Arm Exercise HowTo

About.com Breast Cancer — Fri, 14 Aug 2009 23:00:00 +0100

Corner push-ups are a great way to stretch your pectoral muscles - major muscles that cross your chest. All you need is a corner of a room and some time to do your corner push-ups. Stretching your pectoral muscles helps you recover from breast surgery. Learn how to do corner push-ups here. (Source: About.com Breast Cancer)

Arm Exercise HowTo

About.com Breast Cancer — Thu, 13 Aug 2009 23:00:00 +0100

Stretching gently to your side is a good way to start recovering from breast surgery. Side stretches can be done in a seated position. These will help with trunk, shoulder, and arm flexibility. Learn how to do side stretches here. (Source: About.com Breast Cancer)

Arm Exercise HowTo

About.com Breast Cancer — Sun, 09 Aug 2009 23:00:00 +0100

To get your shoulder moving again after breast surgery, try this towel stretch - it works your shoulder joint for internal rotation. The towel stretch is best done while standing. Doing the towel stretch twice a day will improve your shoulder flexibility and range of motion. Learn how to do the towel stretch here. (Source: About.com Breast Cancer)

Mastectomy Bras and Camisoles

About.com Breast Cancer — Fri, 07 Aug 2009 23:00:00 +0100

Mastectomy bras and camisoles can really help out during your recovery from breast surgery. Mastectomy bras have special pockets to hold a breast prosthesis, and post-surgical camisoles have pockets to hold surgical drains. Learn what features to look for in mastectomy bras and camisoles. (Source: About.com Breast Cancer)

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Breast Cancer Care in Developing Countries

World Journal of Surgery — Fri, 07 Aug 2009 09:37:38 +0100

Conclusions In countries where these limitations are present, there is a need to emphasize public health education, promoting early diagnosis. In addition, resources must be directed toward the creation of more public facilities for cancer treatment. As these goals are met, it is likely that there will be a much-needed improvement in breast cancer care in developing countries. Content Type Journal ArticleDOI 10.1007/s00268-009-0150-zAuthors Gaurav Agarwal, Sanjay Gandhi Postgraduate Institute of Medical Sciences Department of Endocrine and Breast Surgery Raebareli Road Lucknow 226014 IndiaPooja Ramakant, Sanjay Gandhi Postgraduate Institute of Medical Sciences Department of Endocrine and Breast Surgery Raebareli Road Lucknow 226014 IndiaErnesto R. Sánchez Forgach, Ce...

Alternations of ER, PR, HER-2/neu, and P53 protein expression in ductal breast carcinomas and clinical implications

Medical Oncology — Thu, 06 Aug 2009 08:24:44 +0100

In conclusion, these findings substantiate the notion that breast cancer progression is often associated with alterations in expressions of ER, PgR, and HER-2/neu. The underlying mechanisms of these alterations need further investigation. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9279-8Authors Caigang Liu, First Affiliated Hospital of China Medical University Breast Surgery Ward, Department of Oncology Heping 110001 Shenyang Liaoning Province ChinaHao Zhang, First Affiliated Hospital of China Medical University Breast Surgery Ward, Department of Oncology Heping 110001 Shenyang Liaoning Province ChinaChen Shuang, Maternal and Child Health Hospital of Jinzhou Jinzhou ChinaYang Lu, First Affiliated Hospital of China Medical University Breast Surgery Ward,...

Arm Exercise HowTo

About.com Breast Cancer — Wed, 05 Aug 2009 23:00:00 +0100

Wall climbing is a good way to stretch if you have a frozen shoulder or if you're recovering from breast surgery. Wall climbing makes you use your shoulder and arm muscles. Although it's called wall climbing, you will use your hand - not your foot - to walk up the wall. Learn how to do the wall climbing exercise here. (Source: About.com Breast Cancer)

Arm Exercise HowTo

About.com Breast Cancer — Tue, 04 Aug 2009 23:00:00 +0100

Here's a good way to increase the movement in your upper chest and shoulder - elbow winging. This is one of many arm exercises you can do after breast surgery. Do this exercise while lying on your floor or bed. Elbow winging helps with your shoulder rotation and upper chest muscle flexibility. Learn how to do elbow winging. (Source: About.com Breast Cancer)

Saline replacement after local resection of the breast: a simple technique with good control and improved patient satisfaction.

Breast Cancer — Mon, 03 Aug 2009 23:00:00 +0100

CONCLUSIONS: Saline replacement after local resection of the breast is a simple technique that provides benefits for patients undergoing conservative surgery of the breast. PMID: 19653062 [PubMed - as supplied by publisher] (Source: Breast Cancer)

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Breast-Conserving Surgery in BRCA1/2 Mutation Carriers: Are We Approaching an Answer?

Annals of Surgical Oncology — Sun, 02 Aug 2009 06:31:37 +0100

Conclusions Our data suggest that IBTR risk after BCS in BRCA1/2 mutation carriers is increased compared with patients who have sporadic breast cancer. Likewise, the risk of CBC seems to be increased in this group. These risks and the likelihood of developing new primary tumors should be discussed with carriers interested in breast conservation as well as when choosing risk-reducing strategies. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-009-0638-7Authors Carlos A. Garcia-Etienne, European Institute of Oncology Breast Surgery Department Milan ItalyMonica Barile, European Institute of Oncology Department of Cancer Prevention and Genetics Milan ItalyOreste D. Gentilini, European Institute of Oncology Breast Surgery Department Milan ItalyEdoar...

Arm Exercise HowTo

About.com Breast Cancer — Fri, 31 Jul 2009 23:00:00 +0100

This shoulder blade squeeze exercise is good for your shoulder joint and scapula. You can do this exercise in a standing or seated position. This is one of a dozen arm exercises you can do after breast surgery, to increase your flexibility. Here's how to do the shoulder blade squeeze exercise. (Source: About.com Breast Cancer)

Pain perception and detailed visual pain mapping in breast cancer survivors

Breast Cancer Research and Treatment — Thu, 30 Jul 2009 07:57:14 +0100

This study presents a method of visualizing pain areas and assigning them to a pictogram of the body in a sample of breast cancer patients. The method is easy to use and could help generate pain maps in several types of disease. Content Type Journal ArticleCategory Clinical trialDOI 10.1007/s10549-009-0485-zAuthors Sebastian M. Jud, Erlangen University Hospital Department of Gynecology and Obstetrics, University Breast Center for Franconia Universitaetsstrasse 21–23 91054 Erlangen GermanyPeter A. Fasching, Erlangen University Hospital Department of Gynecology and Obstetrics, University Breast Center for Franconia Universitaetsstrasse 21–23 91054 Erlangen GermanyChristian Maihöfner, Erlangen University Hospital Department of Neurology Erlangen GermanyKatharina Heusinger, Erlange...

ASPS' Fat Graft Task Force updates position on safety of autologous fat grafting

Modern Medicine — Wed, 29 Jul 2009 11:09:44 +0100

Although the plastic surgery world has been at odds with the issue of safety and fat grafting procedures with breast surgery, experts report today that there is no indication that fat grafting is an unsafe procedure. (Source: Modern Medicine)

STAT3 activation of tumor-associated macrophages is associated with cytokines of tumor microenvironment and prognostic factors in breast cancer

The Chinese-German Journal of Clinical Oncology — Sat, 25 Jul 2009 04:07:29 +0100

Conclusion STAT3 activation of TAMs may be associate with increasing of IL-1β, TNF-α and TGF-β and decreasing of IL-12 in breast cancer. STAT3 activation of TAMs may also be correlated with histological grade and CerBb-2 status of breast cancer. Content Type Journal ArticleDOI 10.1007/s10330-009-0081-zAuthors Zhengkui Sun, Jiangxi Provincial Cancer Hospital Department of Breast Surgery Nanchang 330029 ChinaShengchun Liu, Chongqing University of Medical Sciences Department of General Surgery, First Affiliated Hospital Chongqing 400016 ChinaZhenxiang Yao, Chongqing University of Medical Sciences Department of General Surgery, First Affiliated Hospital Chongqing 400016 China Journal The Chinese-German Journal of Clinical OncologyOnline ISSN 1613-9089Print ISSN 1...

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Intrapulmonary and Cutaneous Siliconomas after Silent Silicone Breast Implant Failure

The Breast Journal — Sun, 12 Jul 2009 23:00:00 +0100

We present six female patients with an average age of 55 (±5) years with bilateral rupture of silicone implants after breast augmentation for aesthetic reasons. The average time after operation was 18 (±6) years. In five patients, we identified peripheral located cutaneous siliconomas and one patient suffered from an intrapulmonal siliconoma. The diagnosis of bilateral rupture of the silicone implants was performed preoperatively by MRI-scans. All five peripheral cutaneous siliconomas and the intrapulmonal siliconoma were validated by histopathologic analysis. Six female patients suffered from bilateral rupture of silicone implants after breast augmentation. In five patients, we identified peripheral located cutaneous siliconomas which were surgically excised. One patient suffered from a...

Improved Postoperative Pain Control using Thoracic Paravertebral Block for Breast Operations

The Breast Journal — Sun, 12 Jul 2009 23:00:00 +0100

We report our institutional experience with PVB over the initial 8 months of use. All patients undergoing breast operations at the ambulatory care building from September 09, 2005 to June 28, 2005 were reviewed. Comparison was performed between patients receiving PVB and those who did not. Pain scores were assessed immediately, 4 hours, 8 hours and the morning after surgery. 178 patients received PVB and 135 patients did not. Patients were subdivided into three groups: Group A[ndash]segmental mastectomy only (n = 89), Group B[ndash]segmental mastectomy and sentinel node surgery (n = 111) and Group C[ndash]more extensive breast surgery (n = 113). Immediately after surgery there was a statistically significant difference in the number of patients reporting pain between PVB patients and those...

Actress Maura Tierney To Undergo Breast Surgery

About.com Cancer — Sat, 11 Jul 2009 23:00:00 +0100

Maura Tierney, best known for her role on the hit television series E.R., has been diagnosed with a breast tumor and is scheduled to undergo surgery. Rumors about Tierney's health... (Source: About.com Cancer)

Arm Exercise HowTo

About.com Breast Cancer — Thu, 09 Jul 2009 23:00:00 +0100

After breast surgery, you may need to do some arm exercises to regain strength and flexibility. Before you get started, talk to your doctor about doing arm exercises after breast surgery. Here are several easy arm exercises you can do, to keep or regain your range of motion. (Source: About.com Breast Cancer)

Conservative Mastectomies

Aesthetic Plastic Surgery — Thu, 09 Jul 2009 12:45:34 +0100

Abstract Nowadays, oncological breast surgery has to be performed to maximize cosmetic results, and even mastectomies, when unavoidable, should conform to acceptable aesthetics. We investigated surgical approaches to skin-sparing mastectomies. Scar positioning and volume replacement were evaluated. We also discuss nipple-sparing mastectomy (NSM), probably the most outstanding item in the current debate on breast shape preservation. We give suggestions for safe admission criteria and effective treatment. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00266-009-9382-4Authors Maurizio B. Nava, Istituto Nazionale Tumori Unit of Plastic and Reconstructive Surgery Via Venezian 1 20133 Milan ItalyGiuseppe Catanuto, Istituto Nazionale Tumori Unit of Plastic and Reconstr...

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Arm Exercises

About.com Breast Cancer — Sat, 04 Jul 2009 23:00:00 +0100

After breast surgery, it's important to get moving - especially your arm and shoulder on your affected side. Breast surgery affects muscles, nerves, and skin - all of which need exercise after surgery to recover flexibility and strength. Learn more about exercises after breast surgery here. (Source: About.com Breast Cancer)

Electrical impedance scanning in breast tumor imaging: correlation with the growth pattern of lesion.

Chinese Medical Journal — Sat, 04 Jul 2009 23:00:00 +0100

CONCLUSIONS: There are significant differences in the electrical impedance properties between cancerous tissue and healthy tissue. The impedivity of benign tumor is lower, and is at the same level with that of the mammary glandular tissue. The distinct growth pattern of breast lesions determined the different electrical impedance characteristics in the EIS results. PMID: 19719937 [PubMed - in process] (Source: Chinese Medical Journal)

Indications

Internal Medicine News — Tue, 30 Jun 2009 23:00:00 +0100

With the world economy currently contemplating a DNR order, you would think that employers would have no trouble filling jobs. But that's exactly what's happening in the Czech Republic, where hospitals and clinics are facing a serious shortage of qualified nurses. According to the New York Times, one private surgical clinic in Prague managed to attract nurses with a special benefits package: free German lessons, 5 weeks of vacation, and complimentary liposuction and breast enhancement. Of the 50 nurses who work there, 10 have undergone free plastic surgery, and the clinic's managing director told the Times that it was far more popular than the German lessons. Petra Kalivodova, a nurse who had breast surgery and liposuction on her thighs and stomach, said, “I would rather have plastic sur...

Indications

Family Practice News — Tue, 30 Jun 2009 23:00:00 +0100

Breast gangrene in an HIV-positive patient.

Annals of the Royal College of Surgeons of England — Tue, 30 Jun 2009 23:00:00 +0100

CONCLUSION: Severe necrotising infections may be initial manifestations of HIV infection and patients with such infections should be screened for HIV. PMID: 19622255 [PubMed - in process] (Source: Annals of the Royal College of Surgeons of England)

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Hematoma Risk Should Not Preclude the Use of Venous Thromboembolism Prophylaxis

Aesthetic Surgery Journal — Tue, 30 Jun 2009 23:00:00 +0100

I am appreciative of the pertinent comments made by Drs. Pannucci and Wilkins regarding the role of prophylactic anticoagulant therapy in aesthetic surgery. This provides me an opportunity to clarify my recommendations regarding the use of Lovenox (Sanofi Aventis, Bridgewater, NJ) in major combination body contouring cases. To be sure, I concur with the statement that if “a patient is truly within the highest-risk categories, we urge the surgeon to accept the minimal hematoma risk associated with providing potentially life-saving pharmacologic venous thromboembolic event [VTE] prophylaxis.” With a VTE event, the potential for death or even adverse long-term sequelae makes preventing this complication a higher priority than a hematoma. Nevertheless, the development of a major hematoma o...

Sentinel lymph node biopsy in two Burgundy districts: prospective multicentric study on 528 breast cancers during the year 2005

Archives of Gynecology and Obstetrics — Thu, 25 Jun 2009 06:52:50 +0100

Conclusion Sentinel lymph node biopsy has become routine practice in our Burgundy area. It is mainly dedicated to early stage breast cancer with limited metastatic risk. Our surgeons follow the most recent guidelines and indications are the same regardless of treatment centre. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00404-009-1163-4Authors Stéphanie Boulet, Georges François Leclerc Anticancer Centre Department of Oncological Surgery 1, rue du Professeur Marion 21000 Dijon FranceHervé Tixier, Georges François Leclerc Anticancer Centre Department of Oncological Surgery 1, rue du Professeur Marion 21000 Dijon FranceJean Fraisse, Georges François Leclerc Anticancer Centre Department of Oncological Surgery 1, rue du Professeur Marion 21000 Di...

The augmented TRAM flap: a technique for the large-breasted patients

European Journal of Plastic Surgery — Thu, 18 Jun 2009 15:44:23 +0100

Abstract The transverse rectus abdominis myocutaneous (TRAM) flap is the most common method of autogenous breast reconstruction. In high-risk patients, a reliable and bulky flap is needed to achieve breast symmetry and a mound together with durable satisfactory projection. The purpose of this study is to look into the use of contralateral zones of the pedicled TRAM flap to improve flap survival and to reduce the incidence of fat necrosis in order to achieve good cosmetic results. Seven obese large-breasted patients of cup size C and above who underwent primary breast reconstruction by the same surgeon are presented. In each case, all the four zones of the TRAM flap were used to achieve symmetry of the reconstruction. Patients had mastectomy with or without axillary clearan...

Sequential administration of dose-dense epirubicin/cyclophosphamide followed by docetaxel/capecitabine for patients with HER2-negative and locally advanced or node-positive breast cancer

Cancer Chemotherapy and Pharmacology — Mon, 15 Jun 2009 07:22:14 +0100

Conclusions Sequential treatment with dose-dense EC followed by docetaxel/capecitabine, using a lower capecitabine dose than that approved for MBC, has an acceptable toxicity profile and encouraging activity when used as neoadjuvant or adjuvant treatment of breast cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1049-yAuthors Yago Nieto, Clínica Universitaria de Navarra Department of Medical Oncology Pamplona SpainJosé Manuel Aramendía, Clínica Universitaria de Navarra Department of Medical Oncology Pamplona SpainJaime Espinós, Clínica Universitaria de Navarra Department of Medical Oncology Pamplona SpainSusana De la Cruz, Clínica Universitaria de Navarra Department of Medical Oncology Pamplona SpainOscar Fernández-Hidalgo, C...

Expression of insulin-like growth factor-1 in breast cancer tissues

The Chinese-German Journal of Clinical Oncology — Mon, 15 Jun 2009 06:50:00 +0100

Conclusion The high-level expression of IGF-1 in breast cancer tissues is correlated with carcinogenesis, development and metastasis of breast cancer. Content Type Journal ArticleDOI 10.1007/s10330-009-0056-0Authors Mingxun Chen, The First Affiliated Hospital of Zhengzhou University Department of Breast Surgery Zhengzhou 450052 ChinaMengquan Li, The First Affiliated Hospital of Zhengzhou University Department of Breast Surgery Zhengzhou 450052 ChinaJingruo Li, The First Affiliated Hospital of Zhengzhou University Department of Breast Surgery Zhengzhou 450052 China Journal The Chinese-German Journal of Clinical OncologyOnline ISSN 1613-9089Print ISSN 1610-1979 Journal Volume Volume 8 Journal Issue Volume 8, Number 6 / June, 2009 (Source: The Chinese-Germa...

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[Management of malignant phyllodes tumors of the breast: The experience of the Institut Curie.]

Cancer Radiotherapie — Wed, 10 Jun 2009 23:00:00 +0100

CONCLUSION: Wide breast surgery (that can be conservative in selected patients) is the mainstay of the treatment of non metastatic malignant phyllodes tumors of the breast. To better determine the respective roles of adjuvant systemic treatment and radiotherapy, further clinical studies and the search for new prognostic and predictive factors remain necessary. PMID: 19524472 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)

Postoperative Prophylactic Antibiotics and Surgical Site Infection Rates in Breast Surgery Patients

Annals of Surgical Oncology — Tue, 09 Jun 2009 15:33:16 +0100

Conclusions Although the overall number of patients who developed SSI was relatively small, there was no reduction in the SSI rate among those who received postoperative antibiotic prophylaxis. Because of the potential adverse events associated with antibiotic use, further evaluation of this practice is required. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-009-0542-1Authors Alyssa D. Throckmorton, Mayo Clinic Department of Surgery Rochester MN USAJudy C. Boughey, Mayo Clinic Department of Surgery Rochester MN USASarah Y. Boostrom, Mayo Clinic Department of Surgery Rochester MN USAAndrea C. Holifield, Mayo Clinic Department of Surgery Rochester MN USAMelissa M. Stobbs, Mayo Clinic Mayo Medical School Rochester MN USATanya Hoskin, Mayo Clinic ...

Caution regarding genotyping methodology for a tri-allelic polymorphism in the novel breast cancer susceptibility gene NQO2

Breast Cancer Research and Treatment — Thu, 04 Jun 2009 11:21:29 +0100

Content Type Journal ArticleCategory Letter to the editorDOI 10.1007/s10549-009-0431-0Authors Ke-Da Yu, Fudan University Department of Breast Surgery, Breast Cancer Institute, Cancer Hospital, Institutes of Biomedical Science, Shanghai Medical College 399 Ling-Ling Road 200032 Shanghai People’s Republic of ChinaGen-Hong Di, Fudan University Department of Breast Surgery, Breast Cancer Institute, Cancer Hospital, Institutes of Biomedical Science, Shanghai Medical College 399 Ling-Ling Road 200032 Shanghai People’s Republic of ChinaLei Fan, Fudan University Department of Breast Surgery, Breast Cancer Institute, Cancer Hospital, Institutes of Biomedical Science, Shanghai Medical College 399 Ling-Ling Road 200032 Shanghai People’s Republic of ChinaZhen Hu, Fudan University Department ...

Prospective Surveillance of Surgical Site Infections After Breast Surgery

American Journal of Infection Control — Mon, 01 Jun 2009 04:00:00 +0100

Cathleen Carroll, MLT(ASCP), CIC, Infection Prevention Specialist; Craig Boswell, M.D. FACS; Helen Tadjalli, M.D. FACS; V. Leroy Young, M.D. FACS, Plastic Surgery, Barnes Jewish West County Hospital, Saint Louis, MO; Bernard Camins, M.D. MSCR, Infectious Disease, Washington University School of Medicine, Saint Louis, MO (Source: American Journal of Infection Control)

Telephone pre-anaesthesia assessment for ambulatory breast surgery.

Hong Kong Med J — Sun, 31 May 2009 23:00:00 +0100

CONCLUSION: Preoperative anaesthesia assessment by telephone is an effective means of preoperative assessment in selected patients undergoing ambulatory breast surgery. PMID: 19494372 [PubMed - in process] (Source: Hong Kong Med J)

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Plastic and Reconstructive Surgery of the Breast

Journal of Plastic, Reconstructive & Aesthetic Surgery — Sun, 31 May 2009 23:00:00 +0100

The authors have tried to write a comprehensive book on Plastic and Reconstructive Surgery of the Breast. The book has 11 chapters in 282 pages and contains a very large number of high quality photographs. The authors have invited Philip Blondeel with co-author Alain Gagnon, who added their significant experience with a chapter on SGAP breast reconstruction and Thomas Schoeller with Gottfried Wechselberger, who added their extensive experience with the TMG flap for breast reconstruction. (Source: Journal of Plastic, Reconstructive & Aesthetic Surgery)

Breast Surgery Program Abstracts

ANZ Journal of Surgery — Thu, 28 May 2009 04:00:00 +0100

(Source: ANZ Journal of Surgery)

Autologous Fat Graft in Radiated Tissue Prior to Alloplastic Reconstruction of the Breast: Report of Two Cases

Aesthetic Plastic Surgery — Wed, 27 May 2009 05:51:09 +0100

Conclusion The preliminary results show that fat injection in irradiated tissue prior to breast alloplastic reconstruction may reduce the radiation-related complications on implants. Benefits from fat grafting are in keeping with the theoretical basis of this surgery. Larger studies are needed to confirm our observations. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00266-009-9367-3Authors Marzia Salgarello, University Hospital A. Gemelli Department of Plastic and Reconstructive Surgery, Catholic University of “Sacro Cuore” Largo A. Gemelli 8 00168 Rome ItalyGiuseppe Visconti, University Hospital A. Gemelli Catholic University of “Sacro Cuore” Largo A. Gemelli 8 00168 Rome ItalyEugenio Farallo, University Hospital A. Gemelli Department of Plast...

Breast surgery quality markers identified

MedWire News - Breast Cancer — Sat, 23 May 2009 02:02:42 +0100

US researchers have identified characteristics that could help improve the quality of breast cancer surgery. (Source: MedWire News - Breast Cancer)

Breast surgery quality markers identified

MedWire News - Oncology — Fri, 22 May 2009 00:00:00 +0100

US researchers have identified characteristics that could help improve the quality of breast cancer surgery. (Source: MedWire News - Oncology)

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Inframammary Approach for Removal of Giant Juvenile Fibroadenomas

Journal of the American College of Surgeons — Thu, 21 May 2009 07:52:50 +0100

Diagnosis and management of giant juvenile fibroadenomas in the adolescent breast can be a difficult problem. They are differentiated from simple fibroadenomas based on their large size, occasional rapid growth, and the young patient age. Incidence is reported as 0.5% to 2% of all fibroadenomas. These lesions can grow very large, with reports of some tumors being 17 cm or greater. Surgical management of these lesions reported in the medical literature ranges from simple excision, to breast conservation, to mastectomy with different types of breast reconstruction. Pertinent issues in deciding on the appropriate type of operation in adolescents include concern for malignancy or phyllodes tumor, cosmetic deformities, impact of surgical manipulation on the developing breast, and psychological ...

Preoperative fluid and electrolyte management with oral rehydration therapy

Journal of Anesthesia — Fri, 15 May 2009 06:10:49 +0100

Conclusion The results suggest that the oral rehydration therapy with an oral rehydration solution before surgery is superior to the current preoperative intravenous therapy for the provision of water, electrolytes, and carbohydrates, and this therapy should be considered as an alternative to the intravenous therapy for preoperative fluid and electrolyte management in selected surgical patients in whom there is no reason to suspect delayed gastric emptying. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00540-009-0743-6Authors Hideki Taniguchi, Kanagawa Cancer Center Department of Anesthesiology 1-1-2 Nakao, Asahi-ku Yokohama 241-0815 JapanToshio Sasaki, Kanagawa Cancer Center Department of Anesthesiology 1-1-2 Nakao, Asahi-ku Yokohama 241-0815 Jap...

Rotation Mastopexy: An Anatomical Approach

Aesthetic Plastic Surgery — Wed, 13 May 2009 05:54:00 +0100

Abstract The goal of a mastopexy is to restore the shape and volume of the breast after ptosis of the breast. Ptosis occurs commonly in response to aging and breastfeeding. A low nipple position on the breast mound can be corrected by addressing the skin envelope, but maintenance of upper pole fullness and a youthful shape of the breast is the challenge to surgeons. To address this, techniques using local glandular flaps and implants have been suggested. A new technique has been created with regard to a detailed knowledge of the breast gland’s vascular anatomy. The lower breast gland is raised as a large vascularized flap and rotated into a pocket beneath the upper pole. The operative procedure is presented together with the experience of the first author with a consecut...

Prospective randomized trial of paravertebral block for patients undergoing breast cancer surgery

American Journal of Surgery — Tue, 12 May 2009 00:00:00 +0100

Conclusions: PVB significantly decreases postoperative pain up to 3 hours after breast cancer surgery. (Source: American Journal of Surgery)

Loss of Resistance Technique for Paravertebral Nerve Blockade Using the Episure™ Autodetect™ Syringe—A Case Report

Pain Medicine — Thu, 07 May 2009 04:00:00 +0100

Conclusion. To our knowledge, this is the first described use of the ADS for performing PVB. (Source: Pain Medicine)

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[Evaluation of 3D numerisation with structured light projection in breast surgery.]

Annales de Chirurgie Plastique et Esthetique — Mon, 04 May 2009 23:00:00 +0100

CONCLUSION: The perspectives of 3D numerisation with structured light projection are wide in clinical practice. It could bring a bit of objectivity in breast plastic surgery. PMID: 19423207 [PubMed - as supplied by publisher] (Source: Annales de Chirurgie Plastique et Esthetique)

What Influences Women's Opinions On Their Breast Surgery?

Health News from Medical News Today — Fri, 01 May 2009 08:00:00 +0100

The six major factors that affect how happy a woman feels with the outcome of her breast surgery have been uncovered. Researchers writing in the open access journal BMC Women's Health have determined that, as well as final breast appearance, there are five other major concerns that influence surgical satisfaction. (Source: Health News from Medical News Today)

Satisfaction and quality of life in women who undergo breast surgery: a qualitative study

BioMed Central — Fri, 01 May 2009 04:00:00 +0100

Conclusions: Our conceptual framework establishes the main issues of concern for breast surgery patients. This new framework can be used to help develop local guidelines for future clinical assessment, management and measurement, establish the validity of the current management strategies, and develop evidence-based guidance for the development of new patient reported outcome measures for future outcomes research. (Source: BioMed Central)

Mondor Disease: A Case Report and Review of the Literature

Aesthetic Surgery Journal — Thu, 30 Apr 2009 23:00:00 +0100

Thrombophlebitis of the thoracoepigastric system of veins is a benign disease and, despite its localized involvement and presentation, the condition is known as Mondor disease (MD). A transverse incision made on the thoracoabdominal wall divides the axially arranged superficial veins at a right angle and the presence of unidirectional valves prevents retrograde blood flow, leading to stasis and thrombus formation. The incidence of MD in oncologic breast cases and aesthetic mammaplasties is reported to be 0.95% and 1.07%, respectively. Siliconeadenitis of axillary nodes, on the other hand, is uncommon and has only been reported occasionally. Extensive MD of the left axilla and inner arm is presented following excision of axillary nodes secondary to siliconeadenitis after cohesive gel silico...

Multisite Analysis of 177 Consecutive Primary Breast Augmentations: Predictors for Reoperation

Aesthetic Surgery Journal — Thu, 30 Apr 2009 23:00:00 +0100

Background: Plastic surgeons and manufacturers of breast implants have been examining the complication and reoperation rates of primary breast augmentations for more than 18 years. The seemingly high rates reported by the manufacturers to the United States Food and Drug Administration (FDA) were the impetus for this multicenter study. Objective: This paper reports on data pooled from three plastic surgery practices that were geographically distributed across the United States and examines the reoperation rate, time to reoperation, the reason for reoperation, and specific complications in 177 consecutive primary breast augmentation patients. These data are statistically compared to the manufacturers' 2005 and 2008 FDA data. In addition, the significance of selected variabl...

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What influences women's opinions on their breast surgery?

EurekAlert! - Cancer — Thu, 30 Apr 2009 04:00:00 +0100

(BioMed Central) The six major factors that affect how happy a woman feels with the outcome of her breast surgery have been uncovered. Researchers writing in the open access journal BMC Women's Health have determined that, as well as final breast appearance, there are five other major concerns that influence surgical satisfaction. (Source: EurekAlert! - Cancer)

CHEK2*1100delC does not contribute to risk to breast cancer among Malay, Chinese and Indians in Malaysia

Familial Cancer — Tue, 28 Apr 2009 13:41:05 +0100

Abstract A truncating mutation (1100delC) in the cell cycle checkpoint kinase-2 gene, CHEK2, has been identified as a risk factor for familial and sporadic breast cancer in some Northern and Western European populations. However, the prevalence of CHEK2*1100delC in breast cancer appears to be population dependent. We analysed the prevalence of CHEK2*1100delC in 668 breast cancer cases, of which 542 were invasive breast cancers, from a hospital-based cohort of breast cancer patients from Kuala Lumpur, Malaysia. The variant was not found in any patients in this cohort, suggesting that CHEK2*1100delC is rare in our population, and unlikely to contribute significantly to risk to breast cancer among the Malay, Chinese and Indian ethnic groups in Malaysia. This suggests that scr...

Bs01what next for breast cancer gene testing?

ANZ Journal of Surgery — Mon, 27 Apr 2009 04:00:00 +0100

In 1994 and 1995 the BRCA1 and BRCA2 genes were first discovered. These breakthroughs quickly lead to the clinical testing of these genes in families with multiple cases of breast and ovarian cancer. Whilst different centres apply different criteria for clinical testing, only approximately 20% of high risk families are found to harbour a mutation in one or other of these genes. Despite intense efforts by the research community, there has been no BRCA3 gene uncovered, nor is there likely to be any other high penetrant breast cancer to be found. More recent research efforts have uncovered more moderate and low risk breast cancer susceptibility genes. It remains to be seen if there is any clinical utility in testing for these low penetrant genes in years to come. More promising are the trials...

Bs02sentinel node biopsy for locally recurrent breast cancer

ANZ Journal of Surgery — Mon, 27 Apr 2009 04:00:00 +0100

Conclusions: Lymphatic mapping is possible in the majority of ipsilateral local recurrent and new primary breast cancer patients. Re-operative SNB is technically feasible in the majority of cases where lymphatic drainage is demonstrated. When performed the results change management in the majority of cases. (Source: ANZ Journal of Surgery)