MedWorm: Breast Surgery

Chronic Pain and Resveratrol: The Pleasure of Relief

Psychology Today Food and Diet Center — Tue, 07 Feb 2012 05:26:14 +0100

Life is looking up if you enjoy grapes, peanuts and dark chocolate. Last month it was announced that researchers at the University of Arizona School of Medicine demonstrated that resveratrol, a compound found in these foods, may be beneficial as a treatment for acute and chronic pain conditions.read more (Source: Psychology Today Food and Diet Center)

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Efficacy of zoledronic acid in postmenopausal Japanese women with early breast cancer receiving adjuvant letrozole: 12-month results

Breast Cancer Research and Treatment — Fri, 03 Feb 2012 17:52:05 +0100

Abstract Aromatase inhibitor-associated bone loss has not been proved in the Japanese or Asian women. The aim of this study was to evaluate an upfront or delayed strategy of bone protection therapy with zoledronic acid administered at 4 mg every 6 months in postmenopausal Japanese women with early breast cancer to compare with results of the Z-FAST and ZO-FAST studies in western countries. Postmenopausal women with hormone receptor positive early breast cancer receiving adjuvant letrozole were randomly assigned to receive either upfront or delayed-start zoledronic acid (4 mg intravenously every 6 months). The delayed group received zoledronic acid when lumbar spine (L2–L4) bone mineral density (BMD) decreased to less than young adult mean −2.0SD or w...

Video: Breast cancer surgeries: Are they always necessary?

Health News: CBSNews.com — Wed, 01 Feb 2012 16:39:13 +0100

A new study finds that nearly one-in-four women with breast cancer have more than one surgery. Dr. Rache Simmons, chief of breast surgery at NY-Presbyterian Hospital/Weill Cornell Medical Center, talks to Gayle King and Erica Hill about how the number of surgeries could be reduced. (Source: Health News: CBSNews.com)

Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy

BMC Cancer — Wed, 01 Feb 2012 05:00:00 +0100

Conclusions: uPA and PAI-1 concentrations in ND were higher in women with atypia and cancer compared to women with benign disease. Combining uPA, PAI-1 and TF in the assessment of women requiring diagnostic breast surgery maximized disease prediction. The assessment of these markers may prove useful in early breast cancer detection. (Source: BMC Cancer)

The incremental value of magnetic resonance imaging for breast surgery planning

Surgery Today — Tue, 31 Jan 2012 16:46:47 +0100

Conclusions Assessment of the tumor size, multifocality, multicentricity, and presence of ductal carcinoma in situ by MRI may lead to misinterpretations in the majority of patients. The surgical approach should not be changed based solely on MRI findings. An accurately interpreted MMG combined with USG may be sufficient in most cases. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00595-012-0137-5Authors Sibel Ozkan Gurdal, Department of Surgery, School of Medicine, Namık Kemal University, 100. yıl mahallesi, Tunca caddesi, No: 32, Tekirdağ, Istanbul, TurkeyBeyza Ozcinar, Departments of Surgery, Istanbul University, Istanbul, TurkeyMunire Kayahan, Departments of Surgery, Bezmialem Vakif University Medical Faculty, Istanbul, TurkeyAbdul...

Comparison of ER/PR and HER2 statuses in primary and paired liver metastatic sites of breast carcinoma in patients with or without treatment

Journal of Cancer Research and Clinical Oncology — Tue, 31 Jan 2012 07:10:50 +0100

Conclusions ER/PR and HER2 statuses between primary and liver metastatic lesions of breast carcinoma can be modified after treatment but are stable in most cases during the natural metastatic process. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-012-1150-1Authors Jieqiong Liu, Department of Breast Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaHeran Deng, Department of Breast Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaWeijuan Jia, Department of Breast Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaYunjie Zeng, Department of Pathology, Sun Yat-Sen Memorial Hospital,...

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Accuracy of BRCA1/2 Mutation Prediction Models for Different Ethnicities and Genders: Experience in a Southern Chinese Cohort

World Journal of Surgery — Tue, 31 Jan 2012 07:05:20 +0100

Conclusions The variation in model performance underscores the need for research on larger Asian cohorts as prediction models, and the possible need for customizing these models for different ethnic groups and genders. Content Type Journal ArticlePages 1-12DOI 10.1007/s00268-011-1406-yAuthors Ava Kwong, Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, ChinaConnie H. N. Wong, Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, ChinaDacita T. K. Suen, Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, ChinaMichael Co, Division of Breast Surgery, Department of Surgery, The University of Hong Kong, Hong Kong, ChinaAllison W. Kurian, Department of Healt...

Variability in Reexcision Following Breast Conservation Surgery [Original Contribution]

JAMA — Tue, 31 Jan 2012 05:00:00 +0100

Conclusion Substantial surgeon and institutional variation were observed in reexcision following partial mastectomy in women with invasive breast cancer. (Source: JAMA)

The Impact of Neoadjuvant Chemotherapy on Wound Complication Risk After Breast Cancer Resection and Reconstruction - A Multi-Institutional Assessment

Journal of Surgical Research — Sat, 14 Jan 2012 22:29:04 +0100

Conclusions: in this multi-institutional analysis, neoadjuvant chemotherapy was not associated with post-operative wound complication, regardless of the type of breast surgery performed. Patients and providers can be assured that receipt of neoadjuvant therapy does not increase the risk of post-operative wound complication. (Source: Journal of Surgical Research)

Indications for Sentinel Lymph Node Biopsy in Multifocal and Multicentric Breast Cancer

Journal of Surgical Research — Sat, 14 Jan 2012 22:29:04 +0100

Conclusions: in conclusion, in a select subset of patients with multifocal and multicentric breast cancer, sentinel lymph node biopsy can accurately predict lymph node status with false-negative rates comparable to that of patients with unifocal breast cancer. However, when a multifocal or multicentric breast cancer has an additional relative contraindication to performing sentinel lymph node biopsy, such as neoadjuvant chemotherapy or T>5cm, the false-negative rate increases. (Source: Journal of Surgical Research)

Indications for breast magnetic resonance imaging in an oncology reference center

Radiologia Brasileira — Sat, 14 Jan 2012 19:42:51 +0100

CONCLUSION: In spite of inconclusive findings at conventional imaging studies being the most common indication for breast magnetic resonance imaging, there is no evidence in the literature supporting such a conduct. Because of its high sensitivity and high rate of false positive results, magnetic resonance imaging should be appropriately indicated in order to avoid unnecessary procedures. Once such method is appropriately indicated, it may contribute in the decision making process, constituting an essential tool in the assessment of breast lesions. (Source: Radiologia Brasileira)

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Health-related quality of life, psychological distress, and adverse events in postmenopausal women with breast cancer who receive tamoxifen, exemestane, or anastrozole as adjuvant endocrine therapy: National Surgical Adjuvant Study of Breast Cancer 04 (N-SAS BC 04)

Breast Cancer Research and Treatment — Tue, 10 Jan 2012 16:49:30 +0100

Abstract Health-related quality of life (HRQOL), symptoms of depression, and adverse events (AEs) were compared between Japanese postmenopausal patients with hormone-sensitive breast cancer (BC) who received adjuvant tamoxifen, exemestane, or anastrozole in an open-labeled, randomized, multicenter trial designated as the National Surgical Adjuvant Study of Breast Cancer (N-SAS BC) 04 substudy of the Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial. During the first year of treatment, HRQOL and symptoms of depression were analyzed using the Functional Assessment of Cancer Therapy-Breast (FACT-B) and its Endocrine Symptom Subscale (ES), and the Center for Epidemiologic Studies Depression Scale (CES-D), respectively. In addition, predefined AEs were analyzed. A total ...

Training a New Generation of Breast Surgeons: Are We Succeeding?

Annals of Surgical Oncology — Wed, 04 Jan 2012 16:51:04 +0100

Conclusions SSO breast oncology fellowships appear to be training confident, well-prepared graduates with good job outlooks, and many are achieving leadership positions. Deficiencies in sonography training, some advanced surgical techniques, and administrative experiences should be addressed by program directors as graduates do perceive the need for such training. Content Type Journal ArticleCategory Breast OncologyPages 1-6DOI 10.1245/s10434-011-2164-7Authors Lisa M. Sclafani, Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USAAaron Bleznak, Section of Surgical Oncology, Lehigh Valley Health Network, John & Dorothy Morgan Cancer Center, Allentown, PA, USATricia Kelly, Breast Care Specialists, Allentown, PA, USAMahmoud B....

The impact of vitamin D status and tumor size on the intraoperative parathyroid hormone dynamics in patients with symptomatic primary hyperparathyroidism

Surgery Today — Wed, 04 Jan 2012 16:48:37 +0100

Conclusions The IOPTH can accurately predict a cure in patients with severe primary hyperparathyroidism. The percentage of decrease in the IOPTH is steeper in patients with lower serum 25-hydroxy vitamin D levels and larger parathyroid tumors. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00595-011-0113-5Authors Gaurav Agarwal, The Departments of Endocrine and Breast Surgery, Endocrine Sciences Centre, SGPGIMS, Raebareli Road, Lucknow, 226014 IndiaDhalapathy Sadacharan, The Departments of Endocrine and Breast Surgery, Endocrine Sciences Centre, SGPGIMS, Raebareli Road, Lucknow, 226014 IndiaPooja Ramakant, The Departments of Endocrine and Breast Surgery, Endocrine Sciences Centre, SGPGIMS, Raebareli Road, Lucknow, 226014 IndiaManoj Shukla,...

Hypermethylation of CpG islands is more prevalent than hypomethylation across the entire genome in breast carcinogenesis

Clinical and Experimental Medicine — Tue, 03 Jan 2012 06:44:57 +0100

This study aimed to establish a high-throughput, genome-wide and non-gene-specific approach to assess the methylation status of multiple CpG islands in parallel and employ it to detect the CpG island methylation profiling alterations in breast carcinogenesis. We used methylation-sensitive restriction fingerprint (MSRF) to screen the permutations of primers that could detect varied and specific methylation profiling in genomic DNA isolated from four different cell lines. Five permutations of nine arbitrary primers were determined for the following experiments based on the above test. We then examined the methylation profiling alterations of CpG islands in 31 breast cancer tissue samples relative to their adjacent non-neoplastic tissues with modified MSRF that replaced silver staining ...

Pulmonary Infection Caused by Mycobacterium conceptionense.

Emerging Infectious Diseases — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Kim SY, Kim MS, Chang HE, Yim JJ, Lee JH, Song SH, Park KU, Song J, Kim EC Abstract TO THE EDITOR: Mycobacterium conceptionense was first identified in 2006 from a patient with posttraumatic osteitis (1). Since then, 3 more isolates have been recovered from a subcutaneous abscess (2), a wound after breast surgery (3), and an abscess after a fat injection (4). During November 2009 through April 2010, M. conceptionense was isolated from sputum from 4 patients in 2 tertiary hospitals in South Korea. PMID: 22257692 [PubMed - in process] (Source: Emerging Infectious Diseases)

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Defining a Place for Nipple Sparing Mastectomy in Modern Breast Care: An Evidence Based Review

The Breast Journal — Sun, 01 Jan 2012 05:00:00 +0100

This article aims to critically review the indications and limitations of NSM, discuss evidence based intra‐operative protocols and to discuss ways in which radiation therapy may be incorporated in treatment planning following NSM. A comprehensive search of the scientific literature was carried out using PubMed to access all publications related to nipple sparing mastectomy. The search focused specifically on technique, current management, safety, and complications of these procedures. Keywords searched included “Nipple sparing mastectomy,”“breast conserving surgery,”“Nipple areola complex preservation” and “skin sparing mastectomy.” NSM offers an opportunity to preserve native breast envelope without mutilation of nipple‐areola complex (NAC), and avoids multiple surgic...

[Modern breast surgery].

Orvosi Hetilap — Sun, 01 Jan 2012 04:42:22 +0100

Authors: Gulyás G, Mátrai Z, Kunos C, Pesthy P, Doleviczényi Z, Kásler M Abstract Today, as a result of the complex and coordinated medical treatment of breast malignancies the long-term survival rate reaches 80%. Modern breast surgery plays a prominent role in the multidisciplinary treatment of breast tumors. Breast surgery in the 21st century simultaneously performs medical and aesthetic procedures on the same organ. Modern day breast surgery is founded on a complex view of breast malignancies, multidisciplinary cooperation, oncoplastic practice, and selecting the optimal surgery techniques, based on state of the art tools and a detailed treatment plan. Authors present the evolution of modern breast surgery; discuss the procedures such as mastectomy, breast conservation surge...

Breast Radiation Correlates with Side of Parathyroid Adenoma

World Journal of Surgery — Fri, 30 Dec 2011 07:10:26 +0100

Conclusions The present study demonstrates that, similar to prior head and neck radiation, prior breast irradiation correlates with the development of parathyroid disease. Specifically, there is a strong correlation between the side of the radiation therapy and the side of a subsequent parathyroid adenoma. Breast irradiation should therefore be considered a risk factor for the development of parathyroid adenomas. Content Type Journal ArticlePages 1-5DOI 10.1007/s00268-011-1394-yAuthors Monica L. Woll, Department of Surgery, Section of Endocrine Surgery, H4/750 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USAHaggi Mazeh, Department of Surgery, Section of Endocrine Surgery, H4/750 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, US...

Primary and secondary angiosarcomas of the breast: a single institution experience

Breast Cancer Research and Treatment — Fri, 30 Dec 2011 07:08:45 +0100

Abstract Angiosarcomas of the breast (ASB) are rare, representing <1% of breast malignancies. They can develop as a primary or secondary malignancy, also called post-radiation angiosarcoma. The aim of the this study is to discuss diagnosis, treatment, and outcome of primary and secondary ASB patients, diagnosed and treated in a single institution, over a 10-year period and to further compare the two conditions. We retrieved 28 consecutive cases of ASB, diagnosed from 1999 to 2009 at the European Institute of Oncology. Clinical and pathologic findings and survival analyses were performed. Of the 28 cases (27 women and 1 man), eight were primary breast angiosarcomas (PBA) and 20 were secondary breast angiosarcomas (SBA). Median follow-up was 23 months (range 1–112&...

Axillary and Supraclavicular Recurrences are Rare after Axillary Lymph Node Dissection in Breast Cancer

World Journal of Surgery — Wed, 28 Dec 2011 06:54:23 +0100

Conclusions AR and SR are rare events that often are detected concomitantly with distant metastases. SRs are associated with aggressive disease and poor survival. Our results also suggest that regional RT reduces regional recurrences in N2–N3 patients but not in N1 patients, but the retrospective, nonrandomized study setting renders this conclusion as uncertain. Content Type Journal ArticlePages 1-8DOI 10.1007/s00268-011-1399-6Authors Elina T. Siponen, Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, FinlandLeila A. Vaalavirta, Department of Oncology, Helsinki University Central Hospital, Helsinki, FinlandHeikki Joensuu, Department of Oncology, Helsinki University Central Hospital, Helsinki, FinlandMarjut H. K. Leidenius, Breast Surgery Unit, H...

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Factors Affecting Lymph Node Yield in Patients Undergoing Axillary Node Dissection for Primary Breast Cancer: A Single-Institution Review

Annals of Surgical Oncology — Wed, 28 Dec 2011 06:52:26 +0100

Conclusions Age, type of breast surgery, body mass index, and clinical stage have no effect on yield of lymph nodes at axillary lymph node dissection. Neoadjuvant chemotherapy, however, is associated with a far fewer nodes at axillary dissection, and alteration of the guidelines should be considered for this population of patients. Content Type Journal ArticleCategory Breast OncologyPages 1-7DOI 10.1245/s10434-011-2199-9Authors Marie Catherine Lee, Surgical Oncology, Comprehensive Breast Program, Moffitt Cancer Center, Tampa, FL, USARobert Plews, Department of General Surgery, The Ohio State University Medical Center, Columbus, OH, USABhupendra Rawal, Biostatistics Core, Moffitt Cancer Center, Tampa, FL, USAJohn V. Kiluk, Surgical Oncology, Comprehensive Breast Prog...

[Designing a therapeutic education program for patients with lymphedema: Live with lymphedema.]

Journal des Maladies Vasculaires — Wed, 21 Dec 2011 05:00:00 +0100

We report a structured patient education program designed for patients with lymphedema. This program was authorized by the Rhône-Alpes regional health agency in March 2011and is in compliance with the national directives and HAS guidelines. PMID: 22196687 [PubMed - as supplied by publisher] (Source: Journal des Maladies Vasculaires)

Back to the Future: A 15-Year Experience With Polyurethane Foam-Covered Breast Implants Using the Partial-Subfascial Technique

Aesthetic Plastic Surgery — Sat, 17 Dec 2011 06:45:32 +0100

Conclusion The polyurethane foam-covered implants have been proven safe for use in breast surgery. They provide the lowest rate of capsular contracture (0.4% in the current study) and excellent aesthetic results. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00266-011-9826-5Authors Jose Abel de la Peña-Salcedo, Institute for Plastic Surgery, Vialidad de la Barranca S/N, Office 490, Huixquilucan, 52763 MexicoMiguel Angel Soto-Miranda, Institute for Plastic Surgery, Vialidad de la Barranca S/N, Office 490, Huixquilucan, 52763 MexicoJose Fernando Lopez-Salguero, Institute for Plastic Surgery, Vialidad de la Barranca S/N, Office 490, Huixquilucan, 52763 Mexico Journal Aesthetic Plastic SurgeryOnline ISSN 1432-5241Print ISSN 0364-216X ...

Memorial Sloan-Kettering Cancer Center Nomogram to predict the risk of non-sentinel lymph node metastasis in Japanese breast cancer patients

Surgery Today — Tue, 13 Dec 2011 17:05:19 +0100

Conclusions The MSKCC nomogram provides a fairly accurate predicted probability for the likelihood of non-SLN metastases. Accordingly, it served as a useful tool for our Japanese patients with SLN metastases. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s00595-011-0088-2Authors Tatsunari Sasada, Division of Frontier Medical Science, Department of Surgery, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JapanShigeru Murakami, Department of Breast Surgery, Hiroshima University Hospital, Hiroshima, JapanTsuyoshi Kataoka, Department of Breast Surgery, Hiroshima University Hospital, Hiroshima, JapanMasahiro Ohara, Department of Breast Surgery, Hiroshima...

Anaphylaxis to dye during breast surgery

Anaesthesia — Tue, 13 Dec 2011 00:52:47 +0100

(Source: Anaesthesia)

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Many Women Do Not Undergo Breast Reconstruction After Mastectomy

Health News from Medical News Today — Mon, 12 Dec 2011 08:00:00 +0100

Despite the benefits, only a small minority of women, regardless of age, are opting for immediate reconstructive breast surgery after undergoing mastectomy for treatment of breast cancer, according to data presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 6-10, 2011. Research has shown that immediate breast reconstruction after mastectomy improves psychological well-being and quality of life and provides women with improved body image and self-esteem compared with delaying the procedure. However, data from this study, presented by Dawn Hershman, M.D... (Source: Health News from Medical News Today)

Cosmetic surgery prior to diagnosis of breast cancer.

Climacteric — Sat, 03 Dec 2011 05:00:00 +0100

Conclusions Although prior cosmetic breast surgery was reported by few women, breast cancer was diagnosed in two women during the procedure. Surgeons performing elective breast surgery need to understand and apply consistent, reliable breast cancer screening practices. PMID: 22136260 [PubMed - as supplied by publisher] (Source: Climacteric)

Implants cancer alert: Fears over the 50,000 women in Britain who have had the breast surgery

the Mail online | Health — Sat, 03 Dec 2011 00:19:55 +0100

The death of Edwige Ligoneche (pictured), 53, in a Marseille clinic, from a rare form of cancer, has reignited concern over silicone gel implants. (Source: the Mail online | Health)

Corrigendum: Impact of breast surgery on survival in women presenting with metastatic breast cancer

British Journal of Surgery — Fri, 02 Dec 2011 00:03:06 +0100

(Source: British Journal of Surgery)

Surgical management of organ-contained unilateral pheochromocytoma: comparative outcomes of laparoscopic and conventional open surgical procedures in a large single-institution series

Langenbeck's Archives of Surgery — Fri, 25 Nov 2011 17:56:12 +0100

Conclusions Laparoscopic procedures are feasible and as safe and effective as open procedures for patients with organ-contained pheochromocytoma. In a patient cohort where majority of the patients had large (>6 cm) pheochromocytoma, laparoscopic procedures resulted in lesser morbidity and shorter convalescence and provided equal chance for cure of pheochromocytoma and hypertension as conventional open surgical procedures. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00423-011-0879-3Authors Gaurav Agarwal, Department of Endocrine & Breast Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014 IndiaDhalapathy Sadacharan, Department of Endocrine & Breast Surgery, Sanjay Gandhi Postgradua...

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Girdin protein: a new potential distant metastasis predictor of breast cancer

Medical Oncology — Thu, 24 Nov 2011 17:53:27 +0100

Abstract To investigate the expression status and the clinical implications of Girdin protein in breast cancer. The expression status of Girdin protein and clinicopathological parameters in 820 breast cancer specimens was analyzed using immunohistochemistry staining and the relationship between Girdin protein and clinicopathological parameters. The prognosis of breast cancer was subsequently determined. Girdin protein was expressed positively in 295 (35.98%) of the 820 cases examined. The expression of Girdin protein was related to histological type and CerbB2 (P = 0.001, 0.006, and 0.001, respectively). After analyzing survival rates, the cases with highly expressed Girdin protein were shown to attain a significantly more distant metastasis rate and poorer postop...

A double blind randomized trial of wound infiltration with ropivacaine after breast cancer surgery with axillary nodes dissection

BMC Anesthesiology — Thu, 24 Nov 2011 05:00:00 +0100

Conclusion: Single shot infiltration with ropivacaine transiently improves postoperative pain control after breast cancer surgery.Trial registration number: NCT 01404377 (Source: BMC Anesthesiology)

Macromastia: a risk factor for carpal tunnel syndrome?

Hand Surgery — Tue, 22 Nov 2011 02:06:03 +0100

Conclusion: Age, breast size, but not body mass index, have a positive correlation with the CTS. PMID: 22072461 [PubMed - in process] (Source: Hand Surgery)

New study reveals expensive MRIs pushed on women for breast cancer screening have no medical benefit

NaturalNews.com — Fri, 18 Nov 2011 06:51:52 +0100

(NaturalNews) The use of Magnetic Resonance Imaging, better known simply as MRI, for breast cancer screening is increasing and so is its use in guiding breast surgery when cancer is discovered. Obviously, that means healthcare costs are soaring, too, as more and more women are advised to get MRIs in addition to mammograms. The push started in 2007. At that time, the New York Times reported a breast MRI cost $1,000 to $2,000, and sometimes more -- at least 10 times the cost of mammography. So for every million breast MRIs performed each year, healthcare costs spike by at least a billion dollars. Sometimes, but not always, these test are covered by Medicare and insurance.Of course, despite this enormous cost, the only reason doctors and medical centers would be urging women to have these exp...

Lymphatic mapping after previous breast surgery.

Breast — Fri, 18 Nov 2011 05:00:00 +0100

CONCLUSIONS: Lymphatic mapping seems feasible after previous BCT with axillary treatment, in spite of a relatively low identification rate. Aberrant drainage tends to be more frequent after previous treatment with ALND. PMID: 22104251 [PubMed - as supplied by publisher] (Source: Breast)

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Degree of freezing does not affect efficacy of frozen gloves for prevention of docetaxel-induced nail toxicity in breast cancer patients

Supportive Care in Cancer — Wed, 16 Nov 2011 06:49:12 +0100

Conclusion A convenient preparation of FG at −10 to −20°C is almost as effective as a standard preparation at −25 to −30°C, with significantly less discomfort. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00520-011-1308-4Authors H. Ishiguro, Outpatient Oncology Unit, Kyoto University Hospital, Kyoto, JapanS. Takashima, Outpatient Oncology Unit, Kyoto University Hospital, Kyoto, JapanK. Yoshimura, Translational Research Center, Kyoto University Hospital, Kyoto, JapanI. Yano, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, JapanT. Yamamoto, Translational Research Center, Kyoto University Hospital, Kyoto, JapanM. Niimi, Translational Research Center, Kyoto University Hospital, Kyoto, JapanH. Yamashiro, Breast ...

Nausea and vomiting after breast cancer surgery, and relationship with tumor receptor status

Journal of Anesthesia — Sat, 12 Nov 2011 16:52:36 +0100

Conclusion The incidence of PONV is higher for patients below 50 years of age. The positive association between ER positivity and PONV in patients above 50 years of age could be attributed to the altered hormonal milieu in these patients and should be investigated further. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00540-011-1274-5Authors Sumitra Ganesh Bakshi, Department of Anesthesia, Critical Care and Pain, Tata Memorial Hospital, Mumbai, IndiaBipin Jibhkate, Department of Anesthesia, Critical Care and Pain, Tata Memorial Hospital, Mumbai, IndiaRaman Sareen, Department of Anesthesia, Critical Care and Pain, Tata Memorial Hospital, Mumbai, IndiaRajan Badwe, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, I...

Methylation profiles of the BRCA1 promoter in hereditary and sporadic breast cancer among Han Chinese

Medical Oncology — Thu, 10 Nov 2011 16:54:47 +0100

Abstract The development of breast cancer is a multistep process associated with complex changes in host gene expression patterns including inactivation of tumor suppressor genes and activation of oncogenes. Critically, hereditary predisposition plays a significant role in cancer susceptibility. However, mutation of the BRCA1 gene is found only in the minority of hereditary breast cancer, which indicates that there might be alternative, novel mechanisms contributing to inactivation of the BRCA1 gene. Studies have shown that aberrant methylation of genomic DNA plays an important role in carcinogenesis. The aim of this study was to investigate whether DNA methylation may be an alternative mechanism for the inactivation of BRCA1 as an epigenetic modification of the genome and w...

Incidental Detection of Breast Apocrine Carcinoma via Endometrial Cytology.

The Tohoku Journal of Experimental Medicine — Fri, 04 Nov 2011 07:05:02 +0100

Authors: Shiota M, Kotani Y, Umemoto M, Tobiume T, Hoshiai H Abstract Breast apocrine carcinoma is a rare malignancy characterized histologically by a predominance of acidophilic tumor cells exhibiting apocrine metaplasia. Apocrine tumors represent only about 0.4% of all breast cancers. Many cases are diagnosed at stage I or II; thus, the prognosis is better than that for other types of breast cancer. Here we present a 57-year-old female patient with primary apocrine breast carcinoma that was incidentally discovered by endometrial cytology. The patient had undergone routine uterine cancer screening at the age of 56 with resulting positive endometrial cytology. Subsequent histological examination of an endometrial biopsy revealed suspected metastatic uterine adenocarcinoma. Further ...

Obese Women Face Higher Complication Risk After Breast Surgery

MedicineNet Womens Health General — Thu, 03 Nov 2011 07:00:00 +0100

Title: Obese Women Face Higher Complication Risk After Breast SurgeryCategory: Health NewsCreated: 11/2/2011 2:06:00 PMLast Editorial Review: 11/3/2011 (Source: MedicineNet Womens Health General)

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Failure of silicone gel breast implants: Is the mechanical weakening due to shell swelling a significant cause of prostheses rupture?

Journal of the Mechanical Behavior of Biomedical Materials — Tue, 01 Nov 2011 04:00:00 +0100

This study investigates rupture causes by analysing the mechanical properties of failed and intact implants in the recent generation of silicon gel breast implants. The main scope is to assess whether mechanical weakness of the shells should be considered as a major cause of breast implant rupture or, on the contrary, the prosthesis shell damage is likely due to other random factors. Some tests were performed on the shells of a wide number of explanted prostheses, to evaluate the mechanical properties as a function of prostheses status at explantation (intact/ruptured) and variable degree of swelling. A weakening of the shell mechanical properties, so as a significant difference in the ultimate strength and stiffness of intact versus ruptured prostheses, was found. This attenuation of the ...

Surgical anatomy of the pectoral nerves and the pectoral musculature

Clinical Anatomy — Tue, 01 Nov 2011 04:00:00 +0100

AbstractThe pectoral nerves (PNs) may be selectively injured through various traumatic mechanisms such as direct trauma, hypertrophic muscle compression, and iatrogenic injuries (breast surgery and axillary node dissection, pectoralis major muscle transfers). The PN may be surgically recovered through nerve transfers. They may also be used as donors to the musculocutaneous, axillary, long thoracic, and spinal accessory nerves and for reinnervation of myocutaneous free flaps. Thus, in this article, we reviewed the surgical anatomy of PN. A meta‐analysis of the available literature showed that the lateral pectoral nerve (LPN) arises most frequently with two branches from the anterior divisions of the upper and middle trunks (33.8%) or as a single root from the lateral cord (23.4%). The med...

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[The place of skin-sparing mastectomy in oncoplastic breast surgery].

Magyar Onkologia — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Mátrai Z, Gulyás G, Tóth L, Sávolt A, Kunos C, Pesthy P, Bartal A, Kásler M Abstract Despite its ever increasing popularity, there is no evidence-based confirmation so far on the results of skin-sparing mastectomy, introduced 20 years ago. However, the results of countless published retrospective, long-term trials seem to underpin the ability of the precisely implemeted procedure in early stage invasive and in situ breast cancers to yield the oncological results of modified radical mastectomy. As a result of the procedure involving special surgical techniques, the skin not affected by cancer can be preserved, which facilitates immediate reconstruction and improves cosmetic outcome. The effect of postmastectomy radiotherapy on the reconstruction needs to be considered ...

The effect of junior residents on surgical quality: a study of surgical outcomes in breast surgery

American Journal of Surgery — Mon, 31 Oct 2011 04:00:00 +0100

Conclusions: Junior resident participation in BCT procedures was not associated with higher rates of inadequate margins of excision. Patients can be reassured that junior resident involvement in their BCT operations is safe and effective. (Source: American Journal of Surgery)

Obesity linked to surgery complications

Health News - UPI.com — Fri, 28 Oct 2011 05:34:19 +0100

BALTIMORE, Oct. 28 (UPI) -- Obese women who have elective breast surgery are at substantially higher risk than others of complications after the procedure, U.S. plastic surgeons say. (Source: Health News - UPI.com)

Psychological distress among women with newly diagnosed breast cancer.

European Journal of Oncology Nursing — Fri, 28 Oct 2011 04:00:00 +0100

CONCLUSIONS: Distress was reported by 77% of patients. Age and problem list were significantly associated with distress. No significant association between psychological distress and social support was observed. PMID: 22036771 [PubMed - as supplied by publisher] (Source: European Journal of Oncology Nursing)

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Breast Surgery for Teenagers?

Breast Cancer Chronicles — Fri, 21 Oct 2011 16:05:47 +0100

Breasts remain a focal point for men’s eyes and teenage girls’ minds. (Source: Breast Cancer Chronicles)

Psychological evaluation of patients after breast cancer surgery and care strategies improvement

The Chinese-German Journal of Clinical Oncology — Tue, 18 Oct 2011 05:52:36 +0100

Conclusion The self-image of patients who underwent different breast cancer surgeries was influenced by different factors, and individualized nursing should be offered in accordance with the specific situation. Content Type Journal ArticlePages 584-587DOI 10.1007/s10330-011-0837-0Authors Yanjun Zhang, Breast Cancer Department, Department of Surgical Oncology, General Surgery, First Hospital of China Medical University, Shenyang, 110001 ChinaCaigang Liu, Breast Cancer Department, Department of Surgical Oncology, General Surgery, First Hospital of China Medical University, Shenyang, 110001 ChinaFeng Jin, Breast Cancer Department, Department of Surgical Oncology, General Surgery, First Hospital of China Medical University, Shenyang, 110001 China Journal The Chine...

Evaluating TIMP‐1, Ki67, and HER2 as markers for non‐sentinel node metastases in breast cancer patients with micrometastases to the sentinel node

APMIS — Tue, 18 Oct 2011 04:00:00 +0100

Tvedskov TF, Bartels A, Jensen M‐B, Paaschburg B, Kroman N, Balslev E, Brünner N. Evaluating TIMP‐1, Ki67 and HER2 as markers for non‐sentinel node metastases in breast cancer patients with micrometastases to the sentinel node. APMIS 2011.The aim was to investigate whether the biochemical prognostic markers TIMP‐1, Ki67, and HER2 could predict metastatic spread to non‐sentinel nodes (NSN) in breast cancer patients with micrometastases to sentinel node (SN). We included all breast cancer patients with micrometastases to SN operated between 2001 and 2007 at the Department of Breast Surgery, Herlev Hospital. The study was designed as a matched case–control study with 25 cases with micrometastases to SN and, in addition, metastatic spread to NSN and 50 matched controls with microm...

Radio-guided occult lesion localisation for breast lesions under computer-aided MRI guidance: the first experience and initial results.

The British Journal of Radiology — Tue, 18 Oct 2011 04:00:00 +0100

Conclusion: This is the first report documenting the application of MRI-guided ROLL. Based on our preliminary results, this technique is very efficient and seems to be a good alternative to wire localisation. PMID: 22010030 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)

Increased variation of the response index of nociception during noxious stimulation in patients during general anaesthesia

Computer Methods and Programs in Biomedicine — Sun, 16 Oct 2011 18:10:43 +0100

Conclusion: Changes in RN can be used to detect noxious stimuli during surgery. RN also predicted movement in our patients under propofol–remifentanil anaesthesia. (Source: Computer Methods and Programs in Biomedicine)

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The optimal sequence of radiotherapy and chemotherapy in adjuvant treatment of breast cancer

International Archives of Medicine — Sun, 16 Oct 2011 04:00:00 +0100

Conclusion: Regarding disease free survival and treatment toxicities, in our study, we did not find any significant difference between the different radiotherapy and chemotherapy sequences. (Source: International Archives of Medicine)

Breast Surgery Technique Spares Artery for Later CABG (CME/CE)

MedPage Today Cardiovascular — Thu, 13 Oct 2011 17:55:48 +0100

(MedPage Today) -- Modified breast reconstruction using end-to-side anastomosis proved comparable to conventional techniques while preserving the internal mammary artery for future use if needed, results of a small clinical series showed. (Source: MedPage Today Cardiovascular)

Dance/movement therapy for improving psychological and physical outcomes in cancer patients.

Cochrane Database of Systematic Reviews — Tue, 11 Oct 2011 01:20:04 +0100

CONCLUSIONS: We did not find support for an effect of dance/movement therapy on body image. The findings of one study suggest that dance/movement therapy may have a beneficial effect on QoL. However, the limited number of studies prevents us from drawing conclusions concerning the effects of dance/movement therapy on psychological and physical outcomes in cancer patients. PMID: 21975762 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Impact of breast surgery on survival in women presenting with metastatic breast cancer.

The British Journal of Surgery — Fri, 07 Oct 2011 04:08:34 +0100

CONCLUSION: Surgical resection of the primary breast tumour was independently associated with a survival advantage in patients presenting with metastatic breast cancer. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 21858791 [PubMed - in process] (Source: The British Journal of Surgery)

Surgically placed wound catheters (SPWC) and local anesthetic infusion in breast surgery – Efficacy and safety analysis

International Journal of Surgery — Thu, 06 Oct 2011 22:52:31 +0100

Background: The effectiveness of surgically placed wound catheters (SPWC) and local anesthetic infusion in the management of post-operative pain following breast surgery is controversial. This meta-analysis was performed to assess efficacy SPWC compared to other techniques of pain management. (Source: International Journal of Surgery)

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On the day cancellations within the breast surgery directorate

International Journal of Surgery — Thu, 06 Oct 2011 22:52:31 +0100

Introduction: On the day cancellations carry significant consequences for patients, surgical teams and trusts. If a cancellation is made with enough notice, it is possible to reschedule another case. (Source: International Journal of Surgery)

Does breast cancer surgery have a significant thromboembolic risk?

International Journal of Surgery — Thu, 06 Oct 2011 22:52:31 +0100

Background: Studies have estimated the venous thromboembolism (VTE) risk of up to 1.1% in patients undergoing surgery for breast cancer and up to 1.5% for breast reconstruction. Current guidelines recommend use of prophylactic low molecular weight heparin (LMWH) for all patients undergoing surgery for cancer. Local policy for breast surgery is not to give prophylactic LMWH, unless a reconstruction is being performed. Our aim was to compare the rate of deep vein thrombosis (DVT) post-operatively across all surgical specialities. (Source: International Journal of Surgery)

The use of 3D laser imaging and a new breast replica cast as a method to optimize autologous breast reconstruction after mastectomy.

Breast — Thu, 06 Oct 2011 04:00:00 +0100

Authors: Ahcan U, Bracun D, Zivec K, Pavlic R, Butala P Abstract Aesthetically pleasing and symmetrical breasts are the goal of reconstructive breast surgery. Sometimes, however, multiple procedures are needed to improve a reconstructed breast's symmetry and appearance. In order to avoid additional corrective procedures, we have developed a new method that uses a reverse engineering technique to produce what we call a new breast replica cast (NBRC). The NBRC is a mould of the contralateral healthy breast, designed according to preoperative laser 3D images. During surgery, the mould is used to help shape the new breast. With this method, we are able to achieve breast symmetry in terms of volume, projection, contour, and position on the chest wall more accurately, more quickly, and m...

Management of chylous leakage after breast surgery: Report of four cases

Surgery Today — Tue, 04 Oct 2011 05:59:08 +0100

Abstract Chylous leakage is a rare occurrence after breast surgery. Trauma to the thoracic duct and its main distribution may be the main cause of chylous leakage, but the cause of such an injury during breast surgery is unknown. We herein report the first case of chylous leakage from many minimal lymph ducts in a skin flap. In all, four cases of chylous leakage were observed out of 1 096 breast cancer patients who underwent axillary lymph node dissection. Of these four cases, three cases were successfully treated conservatively; however, surgical exploration was performed in the fourth case because of the large drainage volume. Furthermore, we reviewed the recently published studies on chylous leakage after breast surgery; 20 cases (our 4 cases included) have been reporte...

Favorable Outcome of Secondary Axillary Dissection in Breast Cancer Patients with Axillary Nodal Relapse

Annals of Surgical Oncology — Tue, 04 Oct 2011 05:53:22 +0100

Conclusions ALNR is a rare event in treating breast cancer. Young age at diagnosis and medially located tumor are associated with higher risk, but standardized initial axillary dissection to level II and adjuvant hormonal therapy is protective against ALNR. In patients with ALNR, the outcome is not dismal and survival may be improved if further axillary dissection is given. Content Type Journal ArticleCategory Breast OncologyPages 1-7DOI 10.1245/s10434-011-2082-8Authors Shih-Che Shen, Division of Breast Surgery, Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University Medical College, Taoyuan, TaiwanChien-Hung Liao, Division of Breast Surgery, Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University Medical College...

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Videoendoscopic single-port axillary dissection

Journal of Minimal Access Surgery — Mon, 03 Oct 2011 04:00:00 +0100

This report describes the first case of videoendoscopic single-port axillary dissection. In histopathological evaluation, 24 lymph nodes were identified and one node was infiltrated by the cancer cells. Videoendoscopic single-port axillary dissection is a precise and improvable technique. Single-port videoendoscopic axillary dissection could be more feasible with individual tools that will be designed for minimally invasive breast surgery. (Source: Journal of Minimal Access Surgery)

Video: War on breast cancer: Where we stand

Health News: CBSNews.com — Sat, 01 Oct 2011 15:51:09 +0100

Rebecca Jarvis speaks with the chief of breast surgery at Mount Sinai Medical Center in New York Dr. Elisa Port about where we are and how far we've come in the war on breast cancer. (Source: Health News: CBSNews.com)

Quality of life among Egyptian women with breast cancer after sparing mastectomy and immediate autologous breast reconstruction: a comparative study

Breast Cancer Research and Treatment — Thu, 29 Sep 2011 06:19:35 +0100

Abstract Breast reconstruction is considered as an integrated part of the modern breast surgery. The aim of this study is to evaluate whether immediate autologous breast reconstruction influences QOL and patient satisfaction outcomes among Egyptian women with breast cancer in comparison to the traditional mastectomy. This is a prospective study in which 200 Egyptian women with non metastatic breast cancer were included; group I (100 patients) underwent sparing mastectomy with immediate autologous breast reconstruction and group II (100 patients) underwent traditional mastectomy. The patient satisfaction with breast reconstruction was evaluated by special questionnaire and the reasons given by traditional mastectomy patients for not having breast reconstruction were recorde...

Annual mammography after breast cancer may improve survival, researchers say

BMJ Online First — Wed, 28 Sep 2011 04:00:00 +0100

Regular mammographic surveillance of women who have had breast cancer is likely to improve their survival, a new study concludes. The researchers point out, however, that the evidence base is... (Source: BMJ Online First)

Bloody nipple discharge is a predictor of breast cancer risk: a meta-analysis

Breast Cancer Research and Treatment — Tue, 27 Sep 2011 05:52:44 +0100

Abstract Nipple discharge is a common complaint of patients with breast disease. The color of nipple discharge is always the first alarming symptom for patients. It is controversial whether the discharge color is an indicator of an underlying malignancy. The electronic database PubMed was searched for relevant articles. A meta-analysis about the association between the color of nipple discharge and breast cancer risk was conducted. Eight studies, including 3,110 patients, were eligible for this meta-analysis. Compared with patients in non-bloody nipple discharge group (179/1,478), patients in bloody nipple discharge group (404/1,632) had a markedly higher breast cancer risk (OR: 2.27, 95% CI: 1.32–3.89, P < 0.001 for heterogeneity). Compared with patients in ...

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Reoperative Transaxillary Breast Surgery: Using the Axillary Incision to Treat Augmentation-related Complications

Aesthetic Plastic Surgery — Thu, 22 Sep 2011 06:39:43 +0100

Conclusion Transaxillary breast augmentation reoperation is feasible if certain principles are followed. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00266-011-9810-0Authors Filipe Volpe Basile, Plastic Surgery Department, Basile Medical Center, Av. Prof Joao Fiusa 2300, Ribeirao Preto, Sao Paulo, Brazil 14024-230Antonio Roberto Basile, Plastic Surgery Department, Basile Medical Center, Av. Prof Joao Fiusa 2300, Ribeirao Preto, Sao Paulo, Brazil 14024-230 Journal Aesthetic Plastic SurgeryOnline ISSN 1432-5241Print ISSN 0364-216X (Source: Aesthetic Plastic Surgery)

Impact of the genetic screening revolution: understanding and meeting the needs of previvors with a known family mutation in BRCA/BRCA2

Evidence-Based Nursing — Wed, 21 Sep 2011 04:00:00 +0100

Implications for practice and research The increasing availability of genetic testing enables other family members who have not yet developed breast cancer to determine if they have inherited the risk; those with a mutation are known as previvors. Once a previvor is identified, they are faced with complicated, and often difficult, decisions regarding prophylactic surgery, chemoprevention or aggressive screening. Persons considering genetic testing need to understand the potential impact of testing for themselves and family including recommended measures for management before undergoing testing. Further nursing research is needed to identify the best means to communicate risk and genetic testing results. Context Approximately 10% of all women diagnosed with breast cancer have a genetic p...

Safety study of axillary reverse mapping in the surgical treatment for breast cancer patients

Journal of Cancer Research and Clinical Oncology — Tue, 20 Sep 2011 15:46:37 +0100

Conclusion Crossover between breast and ipsilateral arm lymphatic drainage system contributes for ipsilateral arm lymph node metastasis. When ARM and SLNB are simultaneously performed in a patient, selectively preservation of the ARM nodes that do not coincided with SLNs would be safe, even if the SLNs are positive. Pathological lymph node status does not account for the occurrence of metastasis in ARM nodes. ARM nodes could be preserved safely, independent of the pathological lymph node status. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00432-011-1064-3Authors Heran Deng, Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou, 510120 People’s Republic of ChinaLun Chen, Dep...

When informed consent goes poorly: a descriptive study of medical negligence claims and patient complaints.

Med J Aust — Mon, 19 Sep 2011 04:00:00 +0100

CONCLUSIONS: The typical dispute over informed consent involves an operation, often cosmetic, and allegations that a particular complication was not properly disclosed. With Australian courts now looking to patient preferences in setting legal standards of care for risk disclosure, medicolegal disputes provide valuable insights for targeting both quality improvement efforts and risk management activities. PMID: 21929499 [PubMed - in process] (Source: Med J Aust)

The Role of Fat Grafting in Reconstructive and Cosmetic Breast Surgery: A Review of the Literature

Journal of Reconstructive Microsurgery — Fri, 16 Sep 2011 04:00:00 +0100

J reconstr MicrosurgDOI: 10.1055/s-0031-1287675ABSTRACTThe technique of autologous fat transplantation has been dramatically improved since its first introduction in 1893. This surgical approach has more recently been used in both the reconstructive and cosmetic setting, and has subsequently been the subject of much controversy. We sought to compose a detailed and systematic literature review of recent literature on the topic in order to provide surgeons with the data in an organized and easily accessible manner. We selected 19 studies and systematically documented trends in their methods, follow-up procedures, and outcomes, paying particular attention to complications. We chose to include studies that analyzed the outcomes of the surgical procedure in both reconstructive and cosmetic case...

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The experimental research on the inhibiting impacts of RNAi on Cyclin E in breast cancer cell line

The Chinese-German Journal of Clinical Oncology — Thu, 15 Sep 2011 15:51:11 +0100

Conclusion The inhibition of Cyclin E can decrease the breast cancer cell’s growth, increase its sensation to chemical therapy and slow down its cell cycle. The Cyclin E siRNA may provide us a practical tool for further study on the gene therapy to breast cancers. Content Type Journal ArticlePages 502-505DOI 10.1007/s10330-011-0833-4Authors Xueqin Li, Thyroid and Breast Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 ChinaNa Shen, Thyroid and Breast Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 ChinaWenshan He, Thyroid and Breast Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 Chi...

Preoperative radio-chemotherapy in early breast cancer patients: Long-term results of a phase II trial

Radiotherapy and Oncology — Mon, 12 Sep 2011 04:00:00 +0100

Conclusion: Preoperative concurrent administration of RT and CT is an effective regimen. Long-term toxicity is moderate. This association deserves further evaluations in prospective trials. (Source: Radiotherapy and Oncology)

[Treatment of infected breast implant in reconstructive surgery.]

Annales de Chirurgie Plastique et Esthetique — Fri, 09 Sep 2011 04:00:00 +0100

CONCLUSION: This preliminary study provides encouraging results in a selected patient population improving the possibility of a conservative treatment according to a precise and rigourous protocol. PMID: 21908090 [PubMed - as supplied by publisher] (Source: Annales de Chirurgie Plastique et Esthetique)

Vertebral arteria lusoria: a life-threatening condition for oesophageal surgery

Surgical and Radiologic Anatomy — Thu, 08 Sep 2011 06:10:30 +0100

Abstract A rare anatomic variant of the right vertebral artery is reported as an incidental finding in a 78-year-old female patient. The vessel originated from the aortic arch distal to the origin of the left subclavian artery and presented an unusual retroesophageal course, thus was named “vertebral arteria lusoria”. As multi-detector row computed tomography examination is now widely used, this anatomical variant should be considered in any patient undergoing esophageal surgery. Misdiagnosis of such an aberrant vertebral artery may cause life-threatening issues. Content Type Journal ArticleCategory Anatomic VariationsPages 1-3DOI 10.1007/s00276-011-0867-xAuthors Alexis Lacout, Centre d’imagerie Médicale, 47, Boulevard du Pont Rouge, 15000 Aurillac, FranceAntoi...

Carotenoids and breast cancer risk: a meta-analysis and meta-regression

Breast Cancer Research and Treatment — Thu, 08 Sep 2011 05:51:58 +0100

Abstract The purpose of this article is to comprehensively summarize the associations between carotenoids and breast cancer and quantitatively estimate their dose–response relationships. We searched PubMed, Embase, and Cochrane databases (from January 1982 to 1 May 2011) and the references of the relevant articles in English with sufficient information to estimate relative risk or odds ratio and the 95% confidence intervals, and comparable categories of carotenoids. Two reviewers independently extracted data using a standardized form; with any discrepancy adjudicated by the third reviewer. 33 studies met the inclusion criteria. Comparing the highest with the lowest intake: dietary α-carotene intake significantly reduced the breast cancer risk by 9.0% (pooled RR =&n...

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Preoperative radio-chemotherapy in early breast cancer patients: Long-term results of a phase II trial.

Thu, 08 Sep 2011 04:00:00 +0100

CONCLUSION: Preoperative concurrent administration of RT and CT is an effective regimen. Long-term toxicity is moderate. This association deserves further evaluations in prospective trials. PMID: 21907436 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)

Metastasis to sentinel lymph nodes in breast cancer is associated with maturation arrest of dendritic cells and poor co-localization of dendritic cells and CD8+ T cells

Virchows Archiv — Tue, 06 Sep 2011 05:47:18 +0100

In conclusion, our study suggests that sentinel lymph nodes with metastasis have arrest of maturation of dendritic cells, fewer mature dendritic cell interactions with cytotoxic T cells, and more regulatory T cells than sentinel lymph nodes without metastasis in patients with breast cancer. These findings extend our understanding of regional immunosuppression and suggest that most regional immunosuppressive changes are associated with nodal metastasis in breast cancer. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00428-011-1145-3Authors Aaron Scott Mansfield, Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, FinlandPaivi Heikkila, Department of Pathology, Helsinki University Central Hospital, Helsinki, FinlandKarl von Smitten, Brea...

[Lateral Intercostal Artery Perforator (LICAP) flap for lateral breast defect reconstruction.]

Annales de Chirurgie Plastique et Esthetique — Mon, 05 Sep 2011 04:00:00 +0100

Authors: Veber M, Ho Quoc C, Fakiha M, Toussoun G, Delay E Abstract Lateral breast defect after partial mastectomy is a difficult challenge. Pedicled perforator flap is a new indication for breast surgery. Perforator flaps and fat tissue transplant are new concepts in this kind of reconstruction. Lateral intercostal artery perforator (LICAP) flap has been used for a lot of indications. It can be used for lateral breast defect reconstruction. This flap provides several advantages: minimal donor site morbidity, advantages in flap shaping, better aesthetic results and higher patient satisfaction. The aim of this paper is to present indications of LICAP flap. We discuss its advantages and its limits in lateral breast reconstruction after partial mastectomy. LICAP flap provides a new so...

MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer

Virchows Archiv — Sun, 04 Sep 2011 10:45:45 +0100

In this study, we investigated MTA1 expression and analyzed its association with cigarette smoke in NSCLC by immunohistochemistry. To gain a deeper insight into the molecular mechanism underlying the relation between MTA1 and cigarette smoke, we treated the NSCLC cell lines with cigarette smoke extract (CSE). MTA1 mRNA levels and proteins were detected in NSCLC cell lines via reverse transcriptase-polymerase chain reaction (RT-PCR) and western blot analysis. Matrigel invasion assay was performed to evaluate cell invasive ability with the treatment of CSE. Immunohistochemical analysis showed MTA1 expression in NSCLC (61/96, 63.5%) was higher than that in adjacent normal lung tissues (15/96, 15.6%; p < 0.05). Moreover, it was significantly associated with smoking history (p &l...

Is Breast Reduction After Weight Loss Surgery Best?

The Doctors Lounge - Dermatology — Fri, 02 Sep 2011 23:00:00 +0100

Small study finds obese women tend to be unhappy with appearance if they get breast surgery first (Source: The Doctors Lounge - Dermatology)

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Prophylaxis of postoperative nausea and vomiting in elective breast surgery

Journal of Clinical Anesthesia — Thu, 01 Sep 2011 04:00:00 +0100

Conclusion: The frequency of PONV was reduced significantly with both antiemetic combinations. (Source: Journal of Clinical Anesthesia)

The effect on improvement of recovery and pain scores of paravertebral block immediately before breast surgery.

Acta Anaesthesiologica Taiwanica — Thu, 01 Sep 2011 04:00:00 +0100

CONCLUSIONS: PVB given before surgery in combination with GA could provide better postoperative analgesia and better QoR than did GA alone in patients undergoing surgery for unilateral breast cancer. PMID: 21982169 [PubMed - in process] (Source: Acta Anaesthesiologica Taiwanica)

An all-oral combination of metronomic cyclophosphamide plus capecitabine in patients with anthracycline- and taxane-pretreated metastatic breast cancer: a phase II study

Cancer Chemotherapy and Pharmacology — Fri, 26 Aug 2011 16:16:33 +0100

Conclusion The all-oral combination of metronomic CTX plus capecitabine is an effective and convenient and well-tolerated regimen for MBC. (ClinicalTrials.gov number, NCT00589901). Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00280-011-1728-3Authors Zhonghua Wang, Department of Medical Oncology, Cancer Hospital of Fudan University, Shanghai Medical College, 270 Dongan Road, Shanghai, 200032 ChinaJingsong Lu, Department of Breast Surgery, Cancer Hospital of Fudan University, Shanghai Medical College, Shanghai, ChinaShiangjiin Leaw, Department of Medical Oncology, Cancer Hospital of Fudan University, Shanghai Medical College, 270 Dongan Road, Shanghai, 200032 ChinaXiaonan Hong, Department of Medical Oncology, Cancer Hospital of Fudan Unive...

Concepts in aesthetic breast dimensions: Analysis of the ideal breast

Journal of Plastic, Reconstructive and Aesthetic Surgery — Thu, 25 Aug 2011 04:00:00 +0100

Conclusions: Deviation from this pattern yields a less attractive breast – the greater the deviation, the less attractive the breast. The importance of this template lies in its use as a guide for the design of aesthetic breast surgery as well as objective analysis of both good and bad results. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

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Delayed breast implant reconstruction: A 10-year prospective study

Journal of Plastic, Reconstructive and Aesthetic Surgery — Wed, 24 Aug 2011 04:00:00 +0100

In conclusion, non-radiated one- and two-stage delayed breast implant reconstructions are associated with substantial risks of complications and reoperation which should be taken into consideration in the planning of breast reconstruction. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

Impact of breast surgery on survival in women presenting with metastatic breast cancer

British Journal of Surgery — Thu, 18 Aug 2011 23:00:00 +0100

Conclusion:Surgical resection of the primary breast tumour was independently associated with a survival advantage in patients presenting with metastatic breast cancer. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Source: British Journal of Surgery)

Iatrogenic displacement of tumor cells to the sentinel node after surgical excision in primary breast cancer

Breast Cancer Research and Treatment — Thu, 18 Aug 2011 05:59:17 +0100

Abstract Isolated tumor cells (ITC) are more common in the sentinel node (SN) after needle biopsy of a breast cancer, indicating iatrogenic displacement of tumor cells. We here investigate whether similar iatrogenic displacement occurs after surgical excision of a breast tumor. We compared the incidence of ITC in the SN of 414 breast cancer patients with recent surgical excision to a group of 16,960 patients without recent surgical procedure in a multivariate analysis by linking data from the Danish Breast Cancer Cooperative Group database and the Danish National Health Register. Moreover, the incidence of spread to non-SNs in patients with ITC in the SN after recent surgical excision was analyzed. We found an adjusted odds ratio on 3.73 (95% CI 2.57–5.43; P <&nb...

Engineering of vascularized adipose constructs

Cell and Tissue Research — Thu, 18 Aug 2011 05:48:29 +0100

In conclusion, both scaffold designs can be effectively used for adipose tissue engineering. Content Type Journal ArticleCategory Regular ArticlePages 1-11DOI 10.1007/s00441-011-1226-2Authors Paul S. Wiggenhauser, Department for Plastic and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 Munich, GermanyDaniel F. Müller, Department for Plastic and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 Munich, GermanyFerry P. W. Melchels, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, AustraliaJosé T. Egaña, Department for Plastic and Hand Surgery, Klinikum Rechts der Isar, Technische Universität München, ...

Breast Cancer in Hong Kong, Southern China: The First Population-Based Analysis of Epidemiological Characteristics, Stage-Specific, Cancer-Specific, and Disease-Free Survival in Breast Cancer Patients: 1997–2001

Annals of Surgical Oncology — Wed, 17 Aug 2011 05:53:22 +0100

Discussion We performed the first comprehensive population-based breast cancer epidemiology study in Southern China using the Hong Kong Cancer Registry database. This provides a baseline study cohort for comparative studies with other Asian countries and Chinese who have migrated to the West. Content Type Journal ArticleCategory American Society of Breast SurgeonsPages 1-7DOI 10.1245/s10434-011-1960-4Authors Ava Kwong, Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Hong Kong, ChinaOscar W. K. Mang, The Hong Kong Cancer Registry, Hospital Authority, Hong Kong, ChinaConnie H. N. Wong, Division of Breast Surgery, Department of Surgery, Queen Mary and Tung Wah Hospital, The University of Hong Kong, Hong ...

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The ‘pecs block’: a novel technique for providing analgesia after breast surgery

Anaesthesia — Fri, 12 Aug 2011 14:42:47 +0100

(Source: Anaesthesia)

Anaphylaxis to dye during breast surgery

Anaesthesia — Fri, 12 Aug 2011 14:42:39 +0100

(Source: Anaesthesia)

Response and prognosis of taxanes and anthracyclines neoadjuvant chemotherapy in patients with triple-negative breast cancer

Journal of Cancer Research and Clinical Oncology — Wed, 10 Aug 2011 15:49:31 +0100

Conclusion Patients with TNBC were more sensitive to neoadjuvant docetaxel plus epirubicin chemotherapy. Compared with non-TNBC patients, TNBC patients had increased pCR rate, but were associated with significantly worse survival. Content Type Journal ArticlePages 1-6DOI 10.1007/s00432-011-1029-6Authors Jiannan Wu, Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou, 510120 People’s Republic of ChinaShunrong Li, Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou, 510120 People’s Republic of ChinaWeijuan Jia, Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou, 510120 People...

The REAL Truth about Breastfeeding

Psychology Today Parenting Center — Fri, 05 Aug 2011 14:20:11 +0100

Many people think that moms can't breastfeed if they work or are on medication. Once again, these misconceptions are a result of a lack of knowledge about breastfeeding.read more (Source: Psychology Today Parenting Center)

[Management of inflammatory breast cancer after neo-adjuvant chemotherapy.]

Cancer Radiotherapie — Wed, 03 Aug 2011 23:00:00 +0100

CONCLUSION: Our data suggest an improvement in locoregional control in patients treated by surgery, in conjunction with chemotherapy and radiotherapy, for inflammatory breast cancer. PMID: 21820933 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)

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A phase III open-label study to assess safety and efficacy of palonosetron for preventing chemotherapy-induced nausea and vomiting (CINV) in repeated cycles of emetogenic chemotherapy

Supportive Care in Cancer — Tue, 02 Aug 2011 06:14:32 +0100

Conclusion The extraordinary safety profile and maintenance of efficacy of 0.75 mg palonosetron combined with dexamethasone were demonstrated throughout repeated chemotherapy cycles. Content Type Journal ArticlePages 1-8DOI 10.1007/s00520-011-1239-0Authors Kenjiro Aogi, Department of Breast Oncology, National Hospital Organization Shikoku Cancer Center, 160 Ko, Minami-Umemoto, Matsuyama, Ehime 791-0280, JapanHiroshi Sakai, Department of Thoracic Oncology, Saitama Cancer Center, Saitama, JapanHirohisa Yoshizawa, Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata, JapanNorikazu Masuda, Department of Surgery, National Hospital Organization Osaka National Hospital, Osaka, JapanNobuyuki Katakami, Division of Integrated Oncolog...

The role of topoisomerase IIα in predicting sensitivity to anthracyclines in breast cancer patients: a meta-analysis of published literatures

Breast Cancer Research and Treatment — Tue, 02 Aug 2011 05:54:10 +0100

Abstract Topoisomerase IIα is not only a proliferation marker of tumor cells, but is also a target for anthracycline-based chemotherapy. Both in vitro and in vivo studies have shown that there is a relationship between topo IIα and chemosensitivity to anthracyclines, but the predictive role of topo IIα in breast cancer patients is still controversial. A meta-analysis based on published studies was performed to obtain an accurate assessment of the association between topo IIα and sensitivity to anthracycline-based chemotherapy. A total of 13 eligible studies, including 2,633 cases and 2,118 controls were identified. Topo IIα was associated with sensitivity to anthracyclines in locally advanced breast cancer patients who received neoadjuvant chemotherapy [five studies, ...

Somatostatin in breast cancer.

Annales de Biologie Clinique — Mon, 01 Aug 2011 04:00:00 +0100

Authors: Frati A, Antoine M, Rodenas A, Gligorov J, Rouzier R, Chéreau E Abstract In man, somatostatin is a hormone mostly produced by hypothalamus. It plays different parts in hormonal regulation through many specific receptors in human body. It has also two interesting actions such as an anti-secretory activity, mostly on the gastrointestinal system and an antiproliferative action on tumor cells. Many synthetic somatostatin analogues, more stable than the natural one, have been developed and are already used in digestive surgery to treat postoperative digestive fistula. Also, the development of specific polyclonal antibodies allowed the identification of five specific somatostatin receptors and their localization in different cell species. The presence of the five receptors in b...

Secondary mammaplasty surgery rewarding with appropriate skills

Modern Medicine — Sun, 31 Jul 2011 23:00:00 +0100

As more and more women undergo Aesthetic breast surgery, the number of patients seeking revision mammaplasty is inevitably increasing. Indisputably, the secondary surgeries are typically much more challenging and risky than a primary procedure. In part because of those issues, however, achieving successful outcomes and satisfied patients after revisional surgery is particularly rewarding, says Angelo Cuzalina, M.D., D.D.S. (Source: Modern Medicine)

Implementation of a clinical pathway in breast cancer patients undergoing breast surgery.

European Journal of Oncology Nursing — Fri, 29 Jul 2011 23:00:00 +0100

CONCLUSION: The results of the study indicate that the implementation of a clinical pathway on patients with breast surgery has a positive effect on increasing patient satisfaction, decreasing patient anxiety levels, and improving their quality of life. PMID: 21807558 [PubMed - as supplied by publisher] (Source: European Journal of Oncology Nursing)

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[Role of nipple sparing mastectomy in modern breast surgery].

Orvosi Hetilap — Fri, 29 Jul 2011 02:45:18 +0100

Authors: Mátrai Z, Gulyás G, Tóth L, Sávolt A, Kunos C, Pesthy P, Bartal A, Kásler M Recently an increasing number of reports of clinical experience have been published on nipple-sparing mastectomy. By the preservation of uninvolved skin and the nipple areola complex, this surgical technique greatly facilitates immediate reconstruction and optimal aesthetic outcome. However, the procedure raises serious oncologic concerns regarding the risk of an occult or a newly formed primary tumor due to parenchyma left behind in the nipple and the retroareola. Despite the ever increasing popularity of the method, there is still no evidence based confirmation to it. According to data from scientific literature on nipple-sparing mastectomy, there is no straightforward consequence to be drawn on...

A Simple Nomogram to Evaluate the Risk of Nonsentinel Node Metastases in Breast Cancer Patients with Minimal Sentinel Node Involvement

Annals of Surgical Oncology — Wed, 27 Jul 2011 05:48:36 +0100

Conclusions Nonsentinel node metastases are rare with micrometastasis or ITC in SN. Most published predictive models for nonsentinel node involvement perform poorly in the present patient population. We developed a new predictive model which seems to perform well in discriminating patients with more than 10% risk of additional metastases. However, the presented nomogram needs to be validated with an independent patient series to evaluate its accuracy, especially for high-risk patients. Content Type Journal ArticlePages 1-10DOI 10.1245/s10434-011-1882-1Authors T. J. Meretoja, Breast Surgery Unit, Department of Gastrointestinal and General Surgery, Helsinki University Central Hospital, Helsinki, FinlandL. Strien, Department of Pathology, Haartman Institute, Helsinki ...

Ductal carcinoma in situ of the male breast presenting as adolescent unilateral gynaecomastia

Journal of Plastic, Reconstructive and Aesthetic Surgery — Fri, 22 Jul 2011 04:00:00 +0100

In conclusion this case describes a rare pre-malignant condition of the male breast. Complete histology of such a lump is the only conclusive investigation necessary and the limitations put upon the surgeon by the “rationing” of such treatment must be overcome on clinical grounds. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

Spectrum of Diseases Presenting as Architectural Distortion on Mammography: Multimodality Radiologic Imaging with Pathologic Correlation

Seminars in Ultrasound CT and MRI — Thu, 21 Jul 2011 19:26:56 +0100

Architectural distortion is the third most-common appearance of breast cancer and often is a subtle finding on mammography. In this article, we review a variety of breast diseases that may present as architectural distortion on mammography; review the utility of correlative imaging, such as ultrasound and magnetic resonance; and review appropriate management for these diagnoses. Primary causes include breast cancer, ductal carcinoma in situ, radial scar, complex sclerosing lesion, and fat necrosis. Secondary etiologies include previous breast surgery, trauma, and infection. Familiarity with imaging findings presenting as distortion on multimodality imaging will optimize detection and management of this subtle-yet-significant finding. (Source: Seminars in Ultrasound CT and MRI)

Effects of a clinical pathway 3 years after implementation in breast surgery

Archives of Gynecology and Obstetrics — Thu, 21 Jul 2011 18:12:21 +0100

Conclusions There is substantial evidence that clinical pathways lead to various improvements in clinical care in surgery. We show a constantly significant effect on duration of hospital stay without any increase in the number of readmissions. In our view, it is not only an economic benefit which prevails here, but also especially a transparency of treatment which leads to higher compliance, better outcome and a shorter length of stay. Content Type Journal ArticlePages 1-6DOI 10.1007/s00404-011-1994-7Authors C. Richter-Ehrenstein, Department of Gynecology, Interdisciplinary Breast Center, Charité-University Medicine Berlin, Charitéplatz 1, 10117 Berlin, GermanyS. Heymann, Medicine Controlling, Charité-University Medicine Berlin, Berlin, GermanyA. Schneider, Depa...

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Detection of Bilateral Breast Cancer at Biennial Screening Mammography in the Netherlands: A Population-based Study [Breast Imaging]

Radiology — Wed, 20 Jul 2011 23:00:00 +0100

Conclusion: The sensitivity of screening mammography in the detection of bilateral breast cancer is disappointingly low. Both screening radiologists and clinical radiologists should pay vigorous attention to the contralateral breast to detect bilateral malignancies without diagnostic delay. © RSNA, 2011 (Source: Radiology)

Breast reconstruction with polyurethane implants: preliminary report

European Journal of Plastic Surgery — Thu, 14 Jul 2011 16:50:07 +0100

In this study, severe capsular contracture was reported in 21.7% of cases with textured prosthesis and in 6.3% of cases with polyurethane implants in patients receiving RT. This difference was statistically significant. As of today, no case of clinically noticeable capsular contracture was seen in non-irradiated patients receiving breast reconstruction with polyurethane-coated implants. These results allow us to establish RT, which is not a severe contraindication to breast reconstruction with implants. Polyurethane implants have provided encouraging results either in terms of lower complication rate and likelihood of capsular contracture. Content Type Journal ArticlePages 1-7DOI 10.1007/s00238-011-0612-zAuthors Stefano Pompei, Plastic and Reconstructive Surgery Unit, Sandro Pe...

Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression

Cancer Causes and Control — Thu, 14 Jul 2011 16:48:21 +0100

Conclusions Our results indicate that both the total intake of vitamin A and retinol could reduce breast cancer risk. However, associations between other vitamins and breast cancer seem to be limited. Content Type Journal ArticlePages 1-14DOI 10.1007/s10552-011-9811-yAuthors Hu Fulan, Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People’s Republic of ChinaJiang Changxing, Center for Endemic Disease Control, Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of ChinaWang Yi Baina, Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang, People’s Republic of ChinaZha...

The paravertebral lamina technique: a new regional anesthesia approach for breast surgery

Journal of Clinical Anesthesia — Wed, 13 Jul 2011 04:00:00 +0100

Conclusions: The lamina technique for placement of a paravertebral catheter is a feasible and effective technique for intraoperative and postoperative analgesia in patients scheduled for major breast surgery with or without axillary lymph node resection. (Source: Journal of Clinical Anesthesia)

Characteristics of Breast Cancers Detected by Ultrasound Screening in Women with Negative Mammograms.

Cancer Science — Tue, 12 Jul 2011 23:00:00 +0100

In conclusion, women with US‐detected breast cancer are more likely to have small‐sized invasive cancer and more likely associated with the luminal A subtype. (Source: Cancer Science)

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Characteristics of breast cancers detected by ultrasound screening in women with negative mammograms

Cancer Science — Tue, 12 Jul 2011 23:00:00 +0100

In conclusion, women with US‐detected breast cancer are more likely to have small‐sized invasive cancer and more likely associated with the luminal A subtype. (Cancer Sci, doi: 10.1111/j.1349‐7006.2011.02034.x, 2011) (Source: Cancer Science)

Are symptomatic guidelines for chemotherapy appropriate to ER-positive screen-detected breast cancer (SDBC)?

Breast Cancer Research and Treatment — Sun, 10 Jul 2011 05:51:06 +0100

Abstract Oncologists recommend chemotherapy to postmenopausal women with adverse prognostic factors, but predictors of the benefit of chemotherapy are mainly based on mortality from symptomatic cancer trials. From 1990 to 1998, 1475 breast cancers (875 screen detected cancers [SDBCs]: 600 symptomatic) were treated in women aged 50–65 years and prognostic factors compared with cancer mortality. Median follow-up was 110 months. The Nottingham Prognostic Index (NPI) was calculated for 6737 breast cancers which were part of the Association of Breast Surgery (ABS) 2001/2002 Audit of SDBCs to validate survival figures. Ten year survival was 92.1% for SDBC and 77.6% for symptomatic cancers. Adjusting for baseline factors, SDBCs had a reduced mortality (RR = ...

Adoption of Surgical Innovations: Factors Influencing Use of Sentinel Lymph Node Biopsy for Breast Cancer.

Surgical Innovation — Wed, 06 Jul 2011 23:00:00 +0100

Conclusions. SLNB is a complex innovation to adopt. Successful adoption was assisted by a high-volume breast cancer surgical champion, interprofessional communication, and administrative support. PMID: 21742665 [PubMed - as supplied by publisher] (Source: Surgical Innovation)

Breast Surgery Proves Riskier for Obese Women (CME/CE)

MedPage Today Primary Care — Tue, 05 Jul 2011 17:00:00 +0100

(MedPage Today) -- Obese women who are considering elective breast surgery may face a nearly 12-fold higher risk of complications, according to a claims database study. (Source: MedPage Today Primary Care)

Mammaplasties and Medicolegal Issues: 50 Cases of Litigation in Aesthetic Surgery of the Breast

Aesthetic Plastic Surgery — Sat, 02 Jul 2011 05:44:14 +0100

Conclusions The evaluation of aesthetic damage is a tricky question due to different aspects such as the psychological component or the frequent lack of adequate photographic documentation of the patient before the operation. Moreover, whenever possible reduction of the damage is proposed, the patient’s willingness to undergo another operation, with all its related costs and benefits, must be considered. Content Type Journal ArticlePages 1-6DOI 10.1007/s00266-011-9768-yAuthors A. Marchesi, Department of Plastic and Reconstructive Surgery, I.R.C.C.S. Policlinico San Donato, Piazza Edmondo Malan, 20097 San Donato Milanese, MI, ItalyM. Marchesi, Department of Legal and Insurance Medicine, Università degli Studi di Milano, Milano, ItalyF. C. Fasulo, Aesthetic Surger...

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Chronic pain following breast surgery

Techniques in Regional Anesthesia and Pain Management — Fri, 01 Jul 2011 04:00:00 +0100

Chronic pain after breast surgery has been known to be a problem for many years. Recent large studies of noncosmetic breast surgery cohorts have found the prevalence to be between 29% and 47%, with up to 13% of those patients reporting their pain as severe. The pain is frequently neuropathic in nature and generally affects the ipsilateral breast, axilla, and arm. A number of risk factors have been found to be associated with the development of pain, including younger age, demographic variables, preoperative pain in the chest/breast, pain in other locations, psychological variables, the surgery performed, acute pain severity, radiation, chemotherapy, hormonal therapy, fear of recurrence, and genetic polymorphisms. Few studies include an adequate preoperative assessment along with the approp...

Docetaxel Followed by Fluorouracil/Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy for Patients with Primary Breast Cancer

Japanese Journal of Clinical Oncology — Wed, 29 Jun 2011 23:00:00 +0100

Conclusions Eight cycles of neoadjuvant chemotherapy—docetaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide—are tolerable and conferred high rates of pathological complete response and breast-conserving surgery. Patients with triple-negative disease were more likely to achieve pathological complete response versus other subtypes, suggesting that selecting appropriate neoadjuvant chemotherapy based on molecular subtype could be possible. (Source: Japanese Journal of Clinical Oncology)

Surgery of the primary tumor does not improve survival in stage IV breast cancer

Breast Cancer Research and Treatment — Tue, 28 Jun 2011 15:48:09 +0100

Abstract We sought to evaluate the survival of patients who received breast surgery prior to any other breast cancer therapy following a metastatic diagnosis. Standard treatment for stage IV breast cancer is systemic therapy without resection of the primary tumor. Registry-based studies suggest that resection of the primary tumor may improve survival in stage IV cancer. We performed a retrospective analysis using data from the National Comprehensive Cancer Network (NCCN) Breast Cancer Outcomes Database. Patients were eligible if they had a metastatic breast cancer diagnosis at presentation with disease at a distant site and either received surgery prior to any systemic therapy or received systemic therapy only. Eligible patients who did not receive surgery were matched to ...

Incidental Papillary Microcarcinoma of the Thyroid—Further Evidence of a Very Low Malignant Potential: A Retrospective Clinicopathologic Study with up to 30 Years of Follow-up

Annals of Surgical Oncology — Tue, 28 Jun 2011 06:03:48 +0100

Content Type Journal ArticlePages 1-1DOI 10.1245/s10434-011-1865-2Authors Sudhi Agarwal, Department of Endocrine and Breast Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, IndiaAmit Agarwal, Department of Endocrine and Breast Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, IndiaGyan Chand, Department of Endocrine and Breast Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 1068-9265 (Source: Annals of Surgical Oncology)

Does antimicrobial homogeneity index influence surgical site infection? A 10-year study in lung, breast, and general surgery

Journal of Infection and Chemotherapy — Mon, 27 Jun 2011 17:48:28 +0100

Abstract To address whether hospital antimicrobial use influences surgical site infection (SSI), we investigated factors including antimicrobial homogeneity index (AHI), an indicator of prescription diversity, with a retrospective study during 120 months for patients undergoing lung, breast, and general surgery (n = 4,510). We analyzed the odds ratios of background factors for SSI and the correlation between AHI and drug susceptibility in isolates of SSI. A total of 243 cases of SSI (5.4%) occurred. Factors that significantly contributed for SSI were operative time [odds ratio (OR), 1.78; 95% confidence interval (CI), 1.33–2.39; P < 0.001], American Society of Anesthesiologists’ score (OR, 1.68, 95% CI, 1.23–2.28; P < 0.001), en...

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Time for a re-evaluation of mammography in the young? Results of an audit of mammography in women younger than 40 in a resource restricted environment

Breast Cancer Research and Treatment — Wed, 22 Jun 2011 15:56:57 +0100

Abstract Mammography in younger women is considered to be of limited value. In a resource restricted environment without access to magnetic resonance imaging (MRI) and with a high incidence of breast cancer in the young, mammography remains an important diagnostic tool. Recent technical advances and better regulation of mammography make a reassessment of its value in these conditions necessary. Data of all the mammograms performed at a tertiary hospital and private breast clinic between January 2003 and July 2009 in women less than 40 years of age were collected. Indications were the presence of a mass, follow-up after primary cancer therapy, and screening for patients perceived at high risk due to a family history or the presence of atypical hyperplasia. Data acquire...

Correlation between docetaxel-induced skin toxicity and the use of steroids and H2 blockers: a multi-institution survey

Breast Cancer Research and Treatment — Wed, 22 Jun 2011 15:56:56 +0100

In conclusion, use of H2 blockers as premedication in breast cancer patients receiving docetaxel significantly increases the risk of both HFS and FE. Content Type Journal ArticlePages 1-8DOI 10.1007/s10549-011-1641-9Authors K. Kawaguchi, Department of Breast Surgery, Kyoto University Hospital, Kyoto, JapanH. Ishiguro, Outpatient Oncology Unit, Kyoto University Hospital, 54 Shogoin-kawaharacho, Sakyo-ku, Kyoto, 606-8507 JapanS. Morita, Department of Biostatistics and Epidemiology, Yokohama City University Medical Center, Yokohama, JapanS. Nakamura, Breast Center, Showa University Hospital, Tokyo, JapanS. Ohno, Division of Breast Oncology, National Kyushu Cancer Center, Fukuoka, JapanN. Masuda, Department of Surgery, Breast Oncology, Osaka National Hospital, Osaka, JapanH. Iwata, Dep...

Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer

Journal of Cancer Research and Clinical Oncology — Tue, 21 Jun 2011 16:42:51 +0100

Conclusion Overexpression of USP22 may contribute to the progression of breast cancer and thus may serve as a new molecular marker to predict the prognosis of breast cancer patients. Content Type Journal ArticlePages 1-9DOI 10.1007/s00432-011-0998-9Authors Youxue Zhang, Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, 150081 ChinaLei Yao, Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, 150081 ChinaXianyu Zhang, Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, 150081 ChinaHongfei Ji, Institute of Cancer Prevention and Treatment, Harbin Medical University, Baojian Road 6, Nangang District, Harbin, 150081 ChinaLihong Wang, I...

Features Associated with Successful Recruitment of Diverse Patients onto Cancer Clinical Trials: Report from the American College of Surgeons Oncology Group

Annals of Surgical Oncology — Fri, 17 Jun 2011 10:54:12 +0100

Discussion AA and HA cancer patients can be successfully accrued onto randomized clinical trials, but study design affects recruitment patterns. Increased socioeconomic disadvantages observed within minority-ethnicity communities results in barriers to screening and more advanced cancer stage distribution. Improving cancer early detection is critical in the effort to eliminate outcome disparities but existing differences in disease burden results in diminished eligibility for early-stage cancer clinical trials among minority-ethnicity patients. Content Type Journal ArticlePages 1-7DOI 10.1245/s10434-011-1818-9Authors Kathleen M. Diehl, Department of Surgery and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USAErin M. Green, Mayo Clinic, Roche...

Associations among baseline variables, treatment-related factors and health-related quality of life 2 years after breast cancer surgery

Breast Cancer Research and Treatment — Fri, 17 Jun 2011 10:50:04 +0100

The objectives of the current study were to clarify the patterns of physical and psychosocial recovery over time, to evaluate the associations among baseline variables, treatment-related factors and HRQOL at 6 months, 1, and 2 years after breast cancer surgery, and to identify the significant factors predicting HRQOL at each point. A multicenter longitudinal study was performed to evaluate physical conditions, anxiety, depression, and HRQOL at 1 month (baseline), 6 months, 1, and 2 years after surgery in 196 patients (mean age: 53.3 years old) with early breast cancer and no postoperative recurrence. Physical conditions were evaluated using a patient-reported symptom checklist. HRQOL was rated using the functional assessment of cancer treatment scale-general ...

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Triple negative breast cancer: 5 years follow-up

The Chinese-German Journal of Clinical Oncology — Tue, 14 Jun 2011 06:06:27 +0100

Conclusion The axillary nodes metastasis is associated with DFS and OS in triple negative breast cancers. Cisplatin-based chemotherapy may be good choice for triple negative breast cancers with metastasis or local recurrence, who received Anthracycline and Taxane-based chemotherapy. Targeted therapies strategies such as EGFR-targeted therapy may be necessary. Content Type Journal ArticlePages 317-320DOI 10.1007/s10330-011-0796-5Authors Xin Zhou, Department of Breast Surgery, Chongqing Cancer Institute, Chongqing, 400030 China Journal The Chinese-German Journal of Clinical OncologyOnline ISSN 1613-9089Print ISSN 1610-1979 Journal Volume Volume 10 Journal Issue Volume 10, Number 6 (Source: The Chinese-German Journal of Clinical Oncology)

Five year survival from breast cancer is lower in deprived areas, says UK report

BMJ Online First — Sun, 12 Jun 2011 23:00:00 +0100

Women living in deprived areas of the United Kingdom are less likely to survive breast cancer because their illness is diagnosed at a later stage than it is among women in the most affluent areas,... (Source: BMJ Online First)

Evaluation of breast lipofilling after sequelae of conservative treatment for cancer

European Journal of Plastic Surgery — Sat, 11 Jun 2011 06:30:23 +0100

Abstract As an indication for the treatment of sequelae of conservative breast cancer surgery, fat transfer in the breast raises two questions: the efficiency of the procedure in terms of volume and curve, and its impact on both breast imaging and oncological evolution. From April 2005 to April 2009, our prospective study included ten consecutive patients. They underwent one-step lipostructure according to Coleman’s technique for the treatment of the sequelae of conservative surgery for breast cancer. We studied the patients’ overall treatment satisfaction graded from 0 to 10 at the first and third months, and 3 years post-intervention. Patients evaluated the rate of fat resorbed in their breast at 1, 3, and 9 months and 3 years post-intervention. They we...

Aesthetic and reconstructive surgery of the breast; Hall-Findlay EJ and Evans GRD (Eds).

European Journal of Plastic Surgery — Fri, 10 Jun 2011 06:26:31 +0100

Content Type Journal ArticlePages 1-1DOI 10.1007/s00238-011-0605-yAuthors Ian Jackson, William Beaumont Hospitals, Beaumont, USA Journal European Journal of Plastic SurgeryOnline ISSN 1435-0130Print ISSN 0930-343X (Source: European Journal of Plastic Surgery)

Breast Cancer Care in the Community: Challenges, Opportunities, and Outcomes

Surgical Oncology Clinics of North America — Mon, 06 Jun 2011 14:49:47 +0100

This article discusses the challenges community breast surgeons face and some ways that the quality of care could be monitored and improved. Quality reporting programs of the Commission on Cancer and Mastery of Breast Surgery Program of the American Society of Breast Surgeons are recommended as tools to track and improve outcomes in breast cancer care. (Source: Surgical Oncology Clinics of North America)

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Breast Sensitivity Before and After the L Short-Scar Mammaplasty

Aesthetic Plastic Surgery — Fri, 03 Jun 2011 06:01:56 +0100

Conclusion After the L short-scar mammaplasty, breast sensitivity to pressure in most cases returns to preoperative levels or improves primarily in those with larger breasts. The data of this prospective study contradict the misconception that mammaplasty techniques with resections at the breast base leave the patient with reduced breast sensitivity because the fundamental neural pathways, such as the lateral neurovascular pedicle, are preserved. Content Type Journal ArticlePages 1-10DOI 10.1007/s00266-011-9756-2Authors Armando Chiari, Rua Herculano de Freitas, 58, Sala 110, Belo Horizonte, Minas Gerais 30430-120, BrazilTarcizo A. Nunes, Department of Surgery, Medical School of the Federal University of Minas Gerais, Av. Alfredo Balena, 190, S. 205, Belo Horiz...

Bone metastasis in a novel breast cancer mouse model containing human breast and human bone

Breast Cancer Research and Treatment — Fri, 03 Jun 2011 05:55:08 +0100

In this study, a set of human breast cancer cell line including MDA-MB-231, MDA-MB-231BO, MCF-7, ZR-75-1 and SUM1315 were characterized their osteotropism in this model. A specific cell line SUM1315 made species-specific bone metastasis, certifying the osteotropism-identification utility of the novel mouse model. Furthermore, gene expression and microRNA expression profiling analysis were done to the two SUM1315 derived sub lines isolated and purified from the orthotopic and metastatic xenograft. In addition, to demonstrate the disparity between the “spontaneous” and “forced” bone metastasis in mouse model, MDA-MB-231 cells were inoculated into both the human implants in this model simultaneously, and then primary cultured and profiling analyzed. Supported by overall results ...

Four sue over breast surgery

Scotsman.com News - Health — Wed, 01 Jun 2011 00:00:00 +0100

FOUR woman have launched legal action against NHS Lothian over the quality of their breast reconstruction. (Source: Scotsman.com News - Health)

Interventions Implemented to Prevent Surgical Site Infections (SSI's) in Breast Procedures at a Community Hospital

American Journal of Infection Control — Mon, 30 May 2011 17:34:33 +0100

The National Healthcare Surveillance Network (NHSN) pooled mean surgical site infection rate for breast surgery is 1.7% (2008 publication) but some investigators have reported much higher infection rates among women who undergo breast surgery due to cancer. We have prospectively followed all breast procedures performed at our hospital since 2007. (Source: American Journal of Infection Control)

Esthetic result of rhomboid flap repair after breast-conserving surgery for lower quadrant breast cancer lesion with skin invasion: Report of two cases

Surgery Today — Mon, 30 May 2011 16:23:55 +0100

Abstract Breast-conserving surgery (BCS) has been increasingly performed as a standard operative strategy for patients with breast cancer. The primary purpose of BCS is to acquire both local control and good cosmetic results. An insignificant difference in cancer treatment results has been shown between BCS and total mastectomy. However, achieving sufficiently cosmetic results can be difficult, particularly in patients with tumors that are large or localized to the lower quadrant. To avoid breast deformities and asymmetries after BCS, immediate reconstruction using autologous tissue has been accepted as the standard option. Rhomboid skin and adipose flap repair is a simple, less invasive procedure than the myocutaneous flap, which has primarily been performed in patients w...

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Breast Metastasis Of Primary Colon Cancer With Micrometastasis In The Axillary Sentinel Node: A Metastasis That Metastasized?

BioMed Central — Fri, 27 May 2011 23:00:00 +0100

In conclusion, solid cancers are able to further metastasize, via well-known pathways also recognized in primary cancers such as neoplastic cell invasion of peritumoral lymphatics. (Source: BioMed Central)

Breast fat grafting gets thumbs up

Modern Medicine — Wed, 25 May 2011 23:00:00 +0100

Officials of Cytori Therapeutics, based here, say British surgeons have successfully used the company’s adipose-derived regenerative cell (ADRC) fat grafting procedure — which the company calls RESTORE — in reconstructive breast surgery, Medical News Today reports. (Source: Modern Medicine)

IORT boost yields improved long-term breast tumor control

AuntMinnie.com Headlines — Mon, 23 May 2011 07:00:00 +0100

Intraoperative radiotherapy (IORT) administered as a boost during breast surgery (more) (Source: AuntMinnie.com Headlines)

The clinical course of immediate breast implant reconstruction after breast cancer.

Acta Oncologica — Sun, 22 May 2011 23:00:00 +0100

Conclusion. Immediate breast implant reconstruction was found to have substantial risks of complications in non-radiated women, which should be considered in the guidance of breast cancer patients before choosing reconstructive procedure. PMID: 21604960 [PubMed - as supplied by publisher] (Source: Acta Oncologica)

A modified technique for nipple-areola complex reconstruction

Indian Journal of Plastic Surgery — Fri, 20 May 2011 23:00:00 +0100

Conclusions: Simple technique and not time consuming. Maintains the consistency and projection of the new nipple. Patient satisfaction. Minimal complication. (Source: Indian Journal of Plastic Surgery)

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Cytori Therapeutics Announces Independent Clinical Study Results In Breast Reconstruction Presented At The Association Of Breast Surgery Conference

Health News from Medical News Today — Tue, 17 May 2011 11:00:00 +0100

Cytori Therapeutics, Inc. (NASDAQ: CYTX) reports that surgeons from North Tees and Hartlepool NHS Foundation Trust have presented clinical outcomes using Adipose-Derived Regenerative Cell (ADRC) fat grafting in reconstructive breast surgery at the Association of Breast Surgery Conference in Manchester, UK, May 16-17, 2011. The procedure, referred to by Cytori as RESTORE, was separately investigated in Cytori's own RESTORE 2 trial... (Source: Health News from Medical News Today)

Timing of breast surgery in premenopausal breast cancer patients.

Cochrane Database of Systematic Reviews — Tue, 17 May 2011 02:00:16 +0100

Authors: Samuel M, Wai KL, Brennan VK, Yong WS The majority of women diagnosed with breast cancer undergo a multidisciplinary treatment with surgical intervention and radiotherapy or chemotherapy, or both. The importance of timing of tumour removal in relation to the menstrual cycle and its influence on disease-free survival and overall survival has been studied by researchers since 1989 but still remains speculative. PMID: 21563138 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer

Breast Cancer Research and Treatment — Wed, 11 May 2011 15:46:08 +0100

Abstract The purpose of the present study was to identify histological surrogate predictive markers of pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC). Among 474 patients who received NAC and subsequent surgical therapy for stage II–III invasive breast carcinoma between 1999 and 2007, 102 (22%) had TNBC, and 92 core needle biopsy (CNB) specimens obtained before NAC were available. As controls, CNB specimens from 42 tumors of the hormone receptor-negative and HER2-positive (HR−/HER2+) subtype and 46 tumors of the hormone receptor-positive and HER2-negative (HR+/HER2−) subtype were also included. Histopathological examination including tumor-infiltrating lymphocytes (TIL) and tumor cell apoptosis, and immun...

Three-dimensional evaluation of breast contour and volume changes following subpectoral augmentation mammaplasty over 6 months

Journal of Plastic, Reconstructive and Aesthetic Surgery — Sun, 08 May 2011 23:00:00 +0100

Conclusions: Breast morphological changes following subpectoral breast augmentation are completed after 3 months. 3-D surface imaging may play a part in comparing different breast-augmentation techniques. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)