MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'AIDS' source. Sun, 05 Feb 2012 18:08:00 +0100 http://www.medworm.com/index.php?rid=5649409&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2012%2F01280%2FEffects_of_vitamin_D_deficiency_and_combination.1.aspx Conclusion: The benefits of vitamin D supplementation in this population need to be demonstrated before widespread ‘test and treat’ policies can be recommended as part of routine clinical practice. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5649409 Sat, 28 Jan 2012 06:00:00 +0100 5649409 http://www.medworm.com/index.php?rid=5649408&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2012%2F01280%2FLong_term_exposure_to_combination_antiretroviral.7.aspx Conclusion: In conclusion, we found no evidence of an increased risk of both all-cause and non-AIDS-related deaths with long-term cumulative cART exposure. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5649408 Sat, 28 Jan 2012 06:00:00 +0100 5649408 http://www.medworm.com/index.php?rid=5598878&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2012%2F01140%2FLevel_of_double_negative_T_cells%2C_which_produce.3.aspx Conclusion: The proportion of double negative T cells at baseline was found to be predictive of the immune activation set point. Our data strongly suggest that double negative T cells may control immune activation in PHI. This effect might be mediated through the production of TGF-β1/IL-10 known to downmodulate immune activation. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5598878 Sat, 14 Jan 2012 06:00:00 +0100 5598878 http://www.medworm.com/index.php?rid=5553101&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2012%2F01140%2FApparent_declining_efficacy_in_randomized_trials__.1.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5553101 Sat, 31 Dec 2011 21:19:21 +0100 5553101 http://www.medworm.com/index.php?rid=5526339&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F11280%2FPhase_2_double_blind%2C_randomized_trial_of.7.aspx Background: The Study of Etravirine Neuropsychiatric Symptoms versus Efavirenz (SENSE) trial compared etravirine with efavirenz in treatment-naive patients. The primary endpoint was neuropsychiatric adverse events up to week 12; HIV RNA suppression at week 48 was a secondary endpoint. Methods: Patients with HIV RNA more than 5000 copies/ml were randomized to etravirine 400 mg once daily (n = 79) or efavirenz (n = 78), plus two nucleoside analogues. HIV RNA less than 50 copies/ml at week 48 was analysed using the time to loss of virological response (TLOVR) algorithm. Drug resistance at treatment failure and safety endpoints were also evaluated. Results: At baseline, the median CD4 cell count was 302 cells/μl and HIV RNA was 4.8 log10 copies/ml. In the intent to treat T... AIDS journals http://www.medworm.com/rss/comments.php?id=5526339 Mon, 28 Nov 2011 06:00:00 +0100 5526339 http://www.medworm.com/index.php?rid=5349170&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F11130%2FTwice_weekly_pegylated_interferon___2a_and.21.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5349170 Wed, 26 Oct 2011 22:41:43 +0100 5349170 http://www.medworm.com/index.php?rid=5459011&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F10230%2FIs_expanded_HIV_treatment_preventing_new.2.aspx There have been dramatic increases in access to antiretroviral therapy (ART) across the developing world, and growing public health attention has focused on the possibility of utilizing ART as a means of slowing the global HIV epidemic. The preventive impact of ART will likely depend on decreasing levels of sexual risk behaviors following treatment initiation. The current review study examines the impact of wider access to ART on sexual risk behaviors among HIV-infected individuals in the developing world. The observational studies to date demonstrate that ART is associated with a significant reduction in unprotected sex following treatment initiation. Although data on the impact of ART on possible risk compensation are rapidly expanding across the developing world, more evidence is still ... AIDS journals http://www.medworm.com/rss/comments.php?id=5459011 Sun, 23 Oct 2011 05:00:00 +0100 5459011 http://www.medworm.com/index.php?rid=5409750&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F10230%2FPreexposure_prophylaxis_and_timed_intercourse_for.9.aspx Many HIV-discordant couples express a strong wish to conceive a child. Insemination with processed semen is offered to these couples in many countries. Given the very low level of transmission risk during fully suppressive antiretroviral therapy, we offered timed intercourse combined with preexposure prophylaxis to further reduce the transmission risk. In 53 cases, natural conception was attempted using the proposed method. Pregnancy rates were high and reached a plateau of 75% after six cycles. Advanced age in the female partner was a predictor for infertility in these couples. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5409750 Sun, 23 Oct 2011 05:00:00 +0100 5409750 http://www.medworm.com/index.php?rid=5286815&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F09240%2FOld_age_and_anti_cytomegalovirus_immunity_are.2.aspx Conclusions: The present findings indicate that HIV-1 infection amplifies the effect of age on naive T-cell levels, and highlight the constraint on the capacity of treated patients to reconstitute their CD4+ T-cell compartment due to age and CMV co-infection. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5286815 Sat, 24 Sep 2011 05:00:00 +0100 5286815 http://www.medworm.com/index.php?rid=5239185&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F09240%2FThe_dynamics_of_appearance_and_disappearance_of.21.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5239185 Thu, 22 Sep 2011 11:51:37 +0100 5239185 http://www.medworm.com/index.php?rid=5349169&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F09100%2FImpact_of_lamivudine_on_HIV_and_hepatitis_B.6.aspx Objective: To examine HIV and hepatitis B virus (HBV)-related outcomes in HIV/HBV-coinfected participants in the PHIDISA II study by use of HBV-active vs. non-HBV-active antiretroviral therapy (ART). Design and methods: PHIDISA II was a randomized study of ART therapy in HIV-infected adults employing zidovudine along with didanosine, or lamivudine along with stavudine in a factorial 2x2 design. HIV/HBV-coinfected participants by randomization received HBV-active or non-HBV-active ART. The following outcomes of interest were examined: immunological recovery and HIV RNA suppression; hepatic flare; HBV DNA suppression; and mortality. Results: HIV/HBV coinfection was present in 106 of 1771 (6%) of participants. Participants with HIV/HBV coinfection were more likely to be men, and have higher b... AIDS journals http://www.medworm.com/rss/comments.php?id=5349169 Sat, 10 Sep 2011 05:00:00 +0100 5349169 http://www.medworm.com/index.php?rid=5185052&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F09100%2FConcurrency_and_the_limited_effectiveness_of.18.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5185052 Sat, 03 Sep 2011 16:26:56 +0100 5185052 http://www.medworm.com/index.php?rid=5227405&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F08240%2FExtended_antenatal_use_of_triple_antiretroviral.6.aspx Objective: To evaluate pregnancy outcomes in a cohort of HIV-infected women receiving triple antiretroviral therapy (ART) for prevention of mother-to-child-transmission. Methods: A retrospective cohort study with review of records of 3273 HIV-positive women receiving prenatal care in Malawi and Mozambique from July 2005 to December 2009 was conducted in Drug Resource Enhancement Against AIDS and Malnutrition (DREAM) centers. Patients were offered nevirapine-based triple ART initiated in pregnancy until 6 months postpartum. Main outcome measures were maternal mortality, abortion/stillbirth, prematurity, and low birth weight. Results: Maternal mortality was 1.2% (42/3273): 7.4% in 68 women with no antenatal ART and 0.7% in 1370 with at least 90 days of antenatal ART [P  (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5227405 Wed, 24 Aug 2011 05:00:00 +0100 5227405 http://www.medworm.com/index.php?rid=5210281&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F08240%2FThe_role_of_coinfections_in_HIV_epidemic.2.aspx Conclusion: Coinfections may increase HIV viral load in populations where they are prevalent, thereby facilitating HIV transmission. These effects may be reversed with treatment. However, to limit HIV trajectory and optimize positive prevention for HIV-infected individuals pre-antiretroviral therapy, we must better understand the mechanisms responsible for augmented viral load and the magnitude of viral load reduction required, and retune treatment regimens accordingly. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5210281 Wed, 24 Aug 2011 05:00:00 +0100 5210281 http://www.medworm.com/index.php?rid=5110669&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F08240%2FVitamin_D_deficiency_is_associated_with_type_2.20.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5110669 Wed, 10 Aug 2011 18:47:16 +0100 5110669 http://www.medworm.com/index.php?rid=5110668&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F08240%2FRelative_time_to_pregnancy_among_HIV_infected_and.19.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5110668 Wed, 10 Aug 2011 18:47:15 +0100 5110668 http://www.medworm.com/index.php?rid=5133040&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F07310%2FElevated_triglycerides_and_risk_of_myocardial.7.aspx Conclusion: Higher triglyceride levels were marginally independently associated with an increased risk of MI in HIV-positive persons, although the extent of reduction in RR after taking account of latest TC, latest HDL-C and other confounders suggests that any independent effect is small. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5133040 Sun, 31 Jul 2011 00:00:00 +0100 5133040 http://www.medworm.com/index.php?rid=5103950&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F07310%2FHIV_1_drug_resistance_at_antiretroviral_treatment.3.aspx Objective: To describe the prevalence of HIV-1 drug resistance mutations at the time of treatment initiation in a large cohort of HIV-infected children previously exposed to single-dose nevirapine (sdNVP) for prevention of transmission. Design: Drug resistance mutations were measured pretreatment in 255 infants and young children under 2 years of age in South Africa exposed to sdNVP and initiating ritonavir-boosted lopinavir-based therapy. Those who achieved viral suppression were randomized to either continue the primary regimen or to switch to a nevirapine-based regimen. Pretreatment samples were tested using population sequencing and real time allele-specific PCR (AS-PCR) to detect Y181C and K103N minority variants. Those with confirmed viremia more than 1000 copies/ml by 52 weeks po... AIDS journals http://www.medworm.com/rss/comments.php?id=5103950 Sun, 31 Jul 2011 00:00:00 +0100 5103950 http://www.medworm.com/index.php?rid=5459012&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F06190%2FReactivity_profiles_of_broadly_neutralizing.1.aspx Conclusion: The reactivity profiles of bNt anti-HIV-1 MAbs are fundamentally distinct from those of pathogenic autoAbs that arise from dysregulated tolerance mechanisms. This suggests that the limited polyreactivity observed for the bNt MAbs, and for HIV-1-Nt Abs in general, may arise through alternative mechanisms, such as extensive somatic mutation due to persistent antigen selection during chronic infection. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5459012 Sun, 19 Jun 2011 05:00:00 +0100 5459012 http://www.medworm.com/index.php?rid=4923969&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F06190%2FNeutralization_of_genetically_diverse_HIV_1.17.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4923969 Mon, 13 Jun 2011 17:35:06 +0100 4923969 http://www.medworm.com/index.php?rid=5021843&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F06010%2FCirculating_inflammatory_biomarkers_can_predict.3.aspx Conclusion: Patients with unmasking TB-IRIS had higher pre-ART levels of plasma IFN-γ and CRP, consistent with preexisting subclinical TB. Paradoxical TB-IRIS was associated with lower levels of biomarkers of monocyte and regulatory T-cell activity, and higher CRP. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5021843 Wed, 01 Jun 2011 00:00:00 +0100 5021843 http://www.medworm.com/index.php?rid=4938971&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F05150%2FHIV_in_hiding__methods_and_data_requirements_for.1.aspx Many people who are HIV positive are unaware of their infection status. Estimation of the number of people with undiagnosed HIV within a country or region is vital for understanding future need for treatment and for motivating testing programs. We review the available estimation approaches which are in current use. They can be broadly classified into those based on prevalence surveys and those based on reported HIV and AIDS cases. Estimation based on prevalence data requires data from regular prevalence surveys in different population groups together with estimates of the size of these groups. The recommended minimal case reporting data needed to estimate the number of patients with undiagnosed HIV are HIV diagnoses, including CD4 count at diagnosis and whether there has been an AIDS diagn... AIDS journals http://www.medworm.com/rss/comments.php?id=4938971 Sun, 15 May 2011 00:00:00 +0100 4938971 http://www.medworm.com/index.php?rid=5031418&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F04240%2FHIV_cure_and_eradication__how_will_we_get_from_the.1.aspx Combination antiretroviral therapy (cART) has led to a major reduction in HIV-related mortality and morbidity; however, HIV can still not be cured. Achieving either a functional cure (long-term control of HIV in the absence of cART) or a sterilizing cure (elimination of all HIV-infected cells) remains a major challenge. The most significant barrier to cure is the establishment of a latent or ‘silent’ infection in resting CD4+ T cells. Several randomized clinical trials have demonstrated that treatment intensification with additional antiretrovirals has little impact on latent reservoirs. Some potential other approaches that may reduce the latent reservoir include very early initiation of cART and the use of agents that could reverse latent infection. Drugs such as histone deacetylase i... AIDS journals http://www.medworm.com/rss/comments.php?id=5031418 Sun, 24 Apr 2011 00:00:00 +0100 5031418 http://www.medworm.com/index.php?rid=4607178&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F03270%2FFactors_associated_with_specific_causes_of_death.29.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4607178 Fri, 18 Mar 2011 17:33:15 +0100 4607178 http://www.medworm.com/index.php?rid=5053784&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F03130%2FEradication_of_HIV_from_the_brain__reasons_for.4.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5053784 Sun, 13 Mar 2011 00:00:00 +0100 5053784 http://www.medworm.com/index.php?rid=4710884&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F03130%2FTriad_of_visual%2C_auditory_and_corticospinal_tract.15.aspx Conclusion: The triad of auditory, visual and corticospinal lesions has been described in rare syndromes and hereditary diseases. This is the first case of this syndrome associated with a HIV infection. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4710884 Sun, 13 Mar 2011 00:00:00 +0100 4710884 http://www.medworm.com/index.php?rid=4546020&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F03130%2FA_randomized_crossover_study_to_compare_efavirenz.28.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4546020 Fri, 04 Mar 2011 17:46:25 +0100 4546020 http://www.medworm.com/index.php?rid=4466287&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F02200%2FHIV_1_transmission_among_HIV_1_discordant_couples.9.aspx Conclusion: HIV-1 transmission may be reduced among HIV-1 discordant couples after initiation of ART due to reductions in HIV-1 viral load and increased consistent condom use. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4466287 Sat, 12 Feb 2011 17:25:20 +0100 4466287 http://www.medworm.com/index.php?rid=4442980&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F02200%2FEfficacy_and_tolerability_of_long_term_efavirenz.21.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4442980 Mon, 07 Feb 2011 17:21:44 +0100 4442980 http://www.medworm.com/index.php?rid=4356959&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F01280%2FVirologic_and_immunologic_response_to_HAART%2C_by.20.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4356959 Tue, 18 Jan 2011 13:42:43 +0100 4356959 http://www.medworm.com/index.php?rid=4356957&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F01280%2FHIV_1_trans_activator_protein_dysregulates_IFN__.19.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4356957 Tue, 18 Jan 2011 13:42:42 +0100 4356957 http://www.medworm.com/index.php?rid=5080971&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F01140%2FHIV_1_viruses_detected_during_episodic_blips.5.aspx Conclusion: The low level viremia induced by IL-7 likely reflects predominantly transient induction or release of virus from a preexisting pool rather than activation of silent quasispecies. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5080971 Fri, 14 Jan 2011 00:00:00 +0100 5080971 http://www.medworm.com/index.php?rid=4353434&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F01140%2FAllogeneic_transplantation_of_CCR5_deficient.20.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4353434 Fri, 14 Jan 2011 00:00:00 +0100 4353434 http://www.medworm.com/index.php?rid=4282735&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2011%2F01140%2FHIV_among_Haitian_born_persons_in_the_United.22.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4282735 Thu, 23 Dec 2010 17:22:55 +0100 4282735 http://www.medworm.com/index.php?rid=5561416&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F11270%2FThe_erythrocyte_sedimentation_rate_in_HIV__a.2.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5561416 Sat, 27 Nov 2010 06:00:00 +0100 5561416 http://www.medworm.com/index.php?rid=5064419&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F11270%2FRebound_of_plasma_viremia_following_cessation_of.6.aspx Conclusions: Our data suggest that a significant reduction in the size of viral reservoirs may be achievable in selected individuals who initiate standard ART early in infection. However, given re-emergence of plasma viremia in an individual with an extraordinarily low viral burden, therapeutic strategies aimed at specifically targeting these extremely rare HIV-infected cells with novel interventions may be necessary in order to achieve eradication of virus. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5064419 Sat, 27 Nov 2010 00:00:00 +0100 5064419 http://www.medworm.com/index.php?rid=4332903&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F11270%2FBroadening_of_CD8__cell_responses_in_vaccine_based.3.aspx Conclusion: These results suggest that vaccine-based wild-type SIV controllers can acquire CD8 cells with the potential to suppress replication of SIV variants carrying CTL escape mutations. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4332903 Sat, 27 Nov 2010 00:00:00 +0100 4332903 http://www.medworm.com/index.php?rid=5572841&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F11130%2FEarly_initiation_of_antiretroviral_therapy_and.6.aspx Conclusion: Earlier initiation is feasible in a low resource, high HIV prevalence setting, and provides important benefits in terms of reduced mortality, morbidity, retention and hospitalization. Donors should fully support the implementation of the latest WHO recommendations. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5572841 Sat, 13 Nov 2010 06:00:00 +0100 5572841 http://www.medworm.com/index.php?rid=5538847&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F11130%2FEntry_and_retention_in_medical_care_among.9.aspx Conclusion: Entry and retention in HIV medical care in the United States are moderately high. Improvement in both outcomes will increase the success of a test and treat strategy. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5538847 Sat, 13 Nov 2010 06:00:00 +0100 5538847 http://www.medworm.com/index.php?rid=5495598&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F11130%2FContemporary_costs_of_HIV_healthcare_in_the_HAART.13.aspx Conclusion: HIV healthcare in the United States continues to be expensive, with the majority of expenditures attributable to medications. With improved HIV survival, costs may increase and should be monitored in the future. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5495598 Sat, 13 Nov 2010 06:00:00 +0100 5495598 http://www.medworm.com/index.php?rid=5442283&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F10230%2FSurvival_analysis_in_infectious_disease_research_.1.aspx Survival analysis methods can be used in infectious disease research to describe the occurrence and timing of clinical or other events subject to censoring and truncation. Here, the survival, hazard, and cumulative hazard functions are defined and simple nonparametric estimators are provided using an illustrative example of survival after AIDS diagnosis. An understanding of these foundational measures is central for an informed use of the survival analysis methods common in infectious disease research. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5442283 Sat, 23 Oct 2010 05:00:00 +0100 5442283 http://www.medworm.com/index.php?rid=5389035&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F10230%2FThe_prevention_of_cervical_cancer_in_HIV_infected.18.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5389035 Sat, 23 Oct 2010 05:00:00 +0100 5389035 http://www.medworm.com/index.php?rid=5389034&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F10230%2FMaternal_and_nenonatal_tenofovir_and_emtricitabine.7.aspx Conclusion: The combination of TDF/FTC to delivering women and their neonates appears well tolerated and to minimize the occurrence of nevirapine viral resistance. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5389034 Sat, 23 Oct 2010 05:00:00 +0100 5389034 http://www.medworm.com/index.php?rid=5389033&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F10230%2FVirologic_and_immunologic_response_to_HAART%2C_by.6.aspx Objective: To determine the impact of age and initial HAART regimen class on virologic and immunologic response within 24 months after initiation. Design: Pooled analysis of data from 19 prospective cohort studies in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). Methods: Twelve thousand, one hundred and ninety-six antiretroviral-naive adults who initiated HAART between 1998 and 2008 using a boosted protease inhibitor-based regimen or a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based regimen were included in our study. Discrete time-to-event models estimated adjusted hazard odds ratios (aHOR) and 95% confidence intervals (CIs) for suppressed viral load (≤500 copies/ml) and, separately, at least 100 cells/μl increase in CD4 cell count. Trunca... AIDS journals http://www.medworm.com/rss/comments.php?id=5389033 Sat, 23 Oct 2010 05:00:00 +0100 5389033 http://www.medworm.com/index.php?rid=4069286&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F10230%2FA_dimeric_form_of_the_HIV_1_antibody_2G12_elicits.26.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4069286 Sat, 16 Oct 2010 09:36:45 +0100 4069286 http://www.medworm.com/index.php?rid=5583582&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F10004%2FCombination_prevention__a_deeper_understanding_of.8.aspx Evidence-informed and human rights-based combination prevention combines behavioural, biomedical, and structural interventions to address both the immediate risks and underlying causes of vulnerability to HIV infection, and the pathways that link them. Because these are context-specific, no single prescription or standard package will apply universally. Anchored in ‘know your epidemic’ estimates of where the next 1000 infections will occur and ‘know your response’ analyses of resource allocation and programming gaps, combination prevention strategies seek to realign programme priorities for maximum effect to reduce epidemic reproductive rates at local, regional, and national levels. Effective prevention means tailoring programmes to local epidemics and ensuring that components are ... AIDS journals http://www.medworm.com/rss/comments.php?id=5583582 Fri, 01 Oct 2010 05:00:00 +0100 5583582 http://www.medworm.com/index.php?rid=5506223&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F10004%2FMale_circumcision_for_HIV_prevention__current.7.aspx Randomized controlled trials in sub-Saharan Africa have shown that adult male circumcision reduces the risk of HIV acquisition in men by about 60%. In this article, we review recent data on the association of male circumcision and HIV/sexually transmitted infection in men and women. This includes a summary of data showing some evidence of an effect of male circumcision against genital ulcer disease, HSV-2 infection, human papillomavirus and , but not or in men. Longitudinal studies among HIV discordant couples suggest that male circumcision may provide some direct long-term benefit to women, which may start after complete wound healing. Circumcision may also protect against HIV acquisition in men who have sex with men (MSM) and those who practice unprotected anal intercourse (either e... AIDS journals http://www.medworm.com/rss/comments.php?id=5506223 Fri, 01 Oct 2010 05:00:00 +0100 5506223 http://www.medworm.com/index.php?rid=5450123&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F10004%2FHIV_vaccines__current_status_worldwide_and_in.6.aspx Since HIV-1 was identified, development of a preventive vaccine has been a major goal. Significant progress toward that goal has been made by 2010. In macaques, a vigorous T effector cell response has protected some animals from disease caused by simian immunodeficiency virus (SIV). Broadly, neutralizing human anti-HIV antibodies have been isolated and their structures, and targets are rapidly being elucidated. For the first time an AIDS vaccine has shown modest protective efficacy in a human clinical trial. To reach the final goal, there is a need for a coordinated global effort, including a range of approaches including novel high-throughput screening techniques, X-ray crystallography, and monoclonal antibody isolation, analysis of T cell responses and their impact on disease progression... AIDS journals http://www.medworm.com/rss/comments.php?id=5450123 Fri, 01 Oct 2010 05:00:00 +0100 5450123 http://www.medworm.com/index.php?rid=4234691&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F09100%2FUnited_States_global_health_policy__HIV_AIDS%2C.1.aspx The Obama administration has unveiled a new 6-year, $63 billion Global Health Initiative. In addition to the reauthorization of the President's Emergency Plan for AIDS Relief (PEPFAR) to fund HIV/AIDS, tuberculosis, and malaria, the plan also supports maternal and child health (MCH) initiatives that are rooted in a proposal known as the Mother and Child Campaign. The architects of the Obama administration's Global Health Initiative recommend funding the Mother and Child Campaign at the expense of future funding increases for PEPFAR. The idea that differing global health initiatives must compete with each other lacks not only ethical legitimacy but also scientific merit. We believe that MCH need not to be framed in opposition to PEPFAR. Confronting illness in isolation - whether by funding ... AIDS journals http://www.medworm.com/rss/comments.php?id=4234691 Fri, 10 Sep 2010 00:00:00 +0100 4234691 http://www.medworm.com/index.php?rid=4299327&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F09003%2FAsia_can_afford_universal_access_for_AIDS.10.aspx This paper draws on published reports, data from the Global Fund to Fight AIDS, Tuberculosis, and Malaria and the Asian Development Bank, and analysis by the Commission on AIDS in Asia to estimate financial resources required to achieve universal access for HIV in low-income and middle-income countries of Asia. It explores optimal use of available resources to mount effective response to AIDS in Asia against an uncertain economic climate. Although there is global commitment to tackle the HIV pandemic, available financing falls short of minimum requirements to achieve universal access to prevention and treatment. To support essential HIV priorities in Asia, the Commission on AIDS in Asia estimated annual resource needs to be US$ 3.1 billion. Yet, in 2007, according to one study, estimated t... AIDS journals http://www.medworm.com/rss/comments.php?id=4299327 Wed, 01 Sep 2010 00:00:00 +0100 4299327 http://www.medworm.com/index.php?rid=5583581&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F08240%2FHIV_transmission_and_high_rates_of_late_diagnoses.16.aspx Conclusion: Our study provides evidence of HIV transmission, high rates of late presentation and an increased risk of short-term mortality among older adults. These findings highlight the need for increased targeted prevention efforts and strategies to increase HIV testing among older adults at risk of HIV. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5583581 Tue, 24 Aug 2010 05:00:00 +0100 5583581 http://www.medworm.com/index.php?rid=5442282&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F08240%2FImmune_activation%2C_apoptosis%2C_and_Treg_activity.3.aspx Conclusion: Lack of CD4 recovery in individuals in whom ART suppresses HIV replication is associated with complex immune alterations. Immune activation, likely driven by altered gut permeability and resulting in augmented Treg activity could play a pivotal role in this process. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5442282 Tue, 24 Aug 2010 05:00:00 +0100 5442282 http://www.medworm.com/index.php?rid=5274986&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F07310%2FAcute_hepatitis_C_in_HIV_infected_men_who_have_sex.1.aspx Since 2000 outbreaks of acute hepatitis C virus (HCV) among HIV-positive men who have sex with men (MSM) who denied injecting drug use have been reported from Europe, the United States, Canada and Australia. Given the burden of liver disease, in particular HCV, on the morbidity and mortality in HIV patients in the era of combination antiretroviral therapy, the rapid and significant rise in the incidence of HCV in the HIV-infected MSM population in high-income countries is alarming. This relates to a significant change in the epidemiology of HCV that has occurred, with HCV emerging as a sexually transmitted infection within this population. Work to date suggests that this permucosal HCV transmission results from high-risk sexual and noninjecting drug use behaviours, reopening the discussion... AIDS journals http://www.medworm.com/rss/comments.php?id=5274986 Sat, 31 Jul 2010 05:00:00 +0100 5274986 http://www.medworm.com/index.php?rid=4198207&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F07310%2FExpanding_access_to_HAART__a_cost_effective.15.aspx Conclusion: Increasing the HAART treatment rate from 50 to 75% of clinically eligible individuals in British Columbia appears to be a cost-effective strategy based on this model. These cost-effectiveness results are consistent with public health objectives: all individuals who are eligible for an established life-saving treatment should receive it. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4198207 Sat, 31 Jul 2010 00:00:00 +0100 4198207 http://www.medworm.com/index.php?rid=3781989&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F07310%2FCytokine_signaling_pathway_polymorphisms_and.26.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3781989 Sat, 24 Jul 2010 05:53:41 +0100 3781989 http://www.medworm.com/index.php?rid=5227407&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F07170%2FRole_of_HIV_1_Tat_in_AIDS_pathogenesis__its.1.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5227407 Sat, 17 Jul 2010 05:00:00 +0100 5227407 http://www.medworm.com/index.php?rid=5639173&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F07002%2FHIV_AIDS_in_the_Middle_East_and_North_Africa__new.1.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5639173 Thu, 01 Jul 2010 05:00:00 +0100 5639173 http://www.medworm.com/index.php?rid=5538848&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F07002%2FHIV_AIDS_among_female_sex_workers%2C_injecting_drug.6.aspx Conclusion: Prevention efforts at greater scale are needed to reach these at-risk populations in Lebanon. These should target MSM in particular, including access to HIV testing, but will need to address and overcome stigma. For IDUs, surveillance and prevention efforts should integrate both hepatitis C virus and HIV. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5538848 Thu, 01 Jul 2010 05:00:00 +0100 5538848 http://www.medworm.com/index.php?rid=5610442&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F06190%2FSafety_of_efavirenz_in_first_trimester_of.8.aspx Conclusion: We found no increased risk of overall birth defects among women exposed to efavirenz during the first trimester of pregnancy compared with exposure to other antiretroviral drugs. Prevalence of overall birth defects with first trimester efavirenz exposure was similar to the ranges reported in the general population. However, the limited sample size for detection of rare outcomes such as neural tube defects prevents a definitive conclusion. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5610442 Sat, 19 Jun 2010 05:00:00 +0100 5610442 http://www.medworm.com/index.php?rid=5227406&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F06190%2FLife_expectancy_of_recently_diagnosed_asymptomatic.15.aspx Conclusion: The life expectancy of asymptomatic HIV-infected patients who are still treatment-naive and have not experienced a CDC-B or C event at 24 weeks after diagnosis approaches that of non-infected individuals. However, follow-up time is short compared to the expected number of years lived. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5227406 Sat, 19 Jun 2010 05:00:00 +0100 5227406 http://www.medworm.com/index.php?rid=5058442&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F06190%2FSeronegative_HIV_1_infection__a_review_of_the.2.aspx We present a retrospective review of the clinical, virologic and immunologic characteristics of 25 persistently seronegative patients whose cases have been published to date and postulate a biologic mechanism for this phenomenon. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5058442 Sat, 19 Jun 2010 00:00:00 +0100 5058442 http://www.medworm.com/index.php?rid=5170989&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F06010%2FHIV_associated_neurocognitive_disorders__is_there.17.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5170989 Tue, 01 Jun 2010 00:00:00 +0100 5170989 http://www.medworm.com/index.php?rid=5145130&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F06010%2FCognitive_dysfunction_in_HIV_patients_despite.2.aspx Conclusion: The prevalence of HANDs is high even in long-standing aviremic HIV-positive patients. However, HANDs without functional repercussion in daily life (asymptomatic neurocognitive impairment) is the most frequent subtype observed. In this population, the HIV dementia scale with a cutoff of 14 points or less seems to provide a useful tool to screen for the presence of HANDs. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5145130 Tue, 01 Jun 2010 00:00:00 +0100 5145130 http://www.medworm.com/index.php?rid=3650344&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F06010%2FHIV_genital_shedding_and_safety_of_Carraguard_use.25.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3650344 Mon, 31 May 2010 23:00:00 +0100 3650344 http://www.medworm.com/index.php?rid=5495599&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F05150%2FAssociation_of_a_single_nucleotide_polymorphism.1.aspx Background: Given that peginterferon-ribavirin treatment is poorly tolerated, there is interest in the identification of predictors of response, particularly in HIV/hepatitis C virus (HCV)-coinfected patients that respond less than HCV-monoinfected individuals. A single nucleotide polymorphism (SNP) near the IL28B gene (rs12979860) has been shown to predict treatment response in HCV-monoinfected patients carrying genotype 1. Information is lacking for HIV/HCV-coinfected individuals and/or other HCV genotypes. Methods: From 650 HIV/HCV-coinfected patients, we identified those who had completed a course of peginterferon-ribavirin therapy with a validated outcome and available repository DNA. The rs12979860 SNP was examined in a blinded fashion. Results: A total of 164 patients were included ... AIDS journals http://www.medworm.com/rss/comments.php?id=5495599 Sat, 15 May 2010 05:00:00 +0100 5495599 http://www.medworm.com/index.php?rid=5477496&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F05150%2FPrevalence_of_transmitted_drug_resistance.15.aspx Conclusion: We presented a clade B-optimized mutation list for evaluating surveillance of TDRM in the United States and analyzed the largest collection of sequence data obtained from individuals newly diagnosed with HIV. The prevalence of TDRM in persons newly diagnosed with HIV is higher than in previous U.S. studies; however, this is not necessarily a significant trend. Continued reporting of sequence data for public health purposes from all sources will improve representativeness and accuracy in analyzing trends in transmitted drug resistance and genetic diversity. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5477496 Sat, 15 May 2010 05:00:00 +0100 5477496 http://www.medworm.com/index.php?rid=5450122&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F05150%2FBetter_mind_the_gap__addressing_the_shortage_of.2.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5450122 Sat, 15 May 2010 05:00:00 +0100 5450122 http://www.medworm.com/index.php?rid=5274987&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F05150%2FDiscordance_between_CD4_cell_count_and_CD4_cell.16.aspx Conclusions: More emphasis should be placed on CD4 cell count than on CD4 percentage in deciding when to start ART in HIV-1-infected children. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5274987 Sat, 15 May 2010 05:00:00 +0100 5274987 http://www.medworm.com/index.php?rid=5133041&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F05150%2FEffectiveness_of_HIV_prevention_for_youth_in.14.aspx Conclusion: There remains a stark mismatch between the HIV burden in youth and the number of attempts to design and test prevention interventions - only two trials report biological outcomes. More effective interventions targeting youth are needed. Attention should go to studying implementation difficulties, sex differences in responses to interventions, determinants of exposure to interventions and perhaps inclusion of other factors apart from HIV/AIDS which influence sexual behaviour. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5133041 Sat, 15 May 2010 00:00:00 +0100 5133041 http://www.medworm.com/index.php?rid=5197103&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F04240%2FPseudomonas_fingernail_infection_successfully.29.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5197103 Sat, 24 Apr 2010 00:00:00 +0100 5197103 http://www.medworm.com/index.php?rid=5660605&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F03270%2FRaltegravir%2C_maraviroc%2C_etravirine__an_effective.17.aspx We prospectively evaluated 28 triple-class experienced HIV-1-infected patients harbouring R5 virus, who received maraviroc, raltegravir and etravirine. By on-treatment analysis, 26 (92%) had less than 50 copies HIV-RNA/ml at week 48. The median (interquartile range) 48-week increase in CD4+ cell counts was 267 (136-355) cells/[mu]l. Three serious adverse events occurred: one recurrence of mycobacterial spondylodiscitis, one anal cancer, one Hodgkin lymphoma. Although long-term safety needs further study, this protease inhibitor and nucleoside analogue-sparing regimen showed sustained efficacy. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5660605 Sat, 27 Mar 2010 05:00:00 +0100 5660605 http://www.medworm.com/index.php?rid=5297830&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F03270%2FThe_high_cost_of_second_line_antiretroviral.15.aspx Conclusion: The gradual increase in second-line numbers that can be expected as treatment programs mature may cause a meaningful increase in the overall average cost per patient treated. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5297830 Sat, 27 Mar 2010 05:00:00 +0100 5297830 http://www.medworm.com/index.php?rid=4987042&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F03270%2FPer_contact_probability_of_HIV_transmission_in.14.aspx Conclusion: Despite the fact that a high proportion of HIV-infected men are on antiretroviral treatment and have undetectable viral load, the per-contact probability of HIV transmission due to UAI is similar to estimates reported from developed country settings in the pre-HAART era. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4987042 Sat, 27 Mar 2010 00:00:00 +0100 4987042 http://www.medworm.com/index.php?rid=3484593&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F03270%2FAssociation_of_HLA_C_and_HCP5_gene_regions_with.23.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3484593 Sat, 27 Mar 2010 00:00:00 +0100 3484593 http://www.medworm.com/index.php?rid=5324747&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F03130%2FWeighing_the_gold_in_the_gold_standard__challenges.2.aspx Conclusion: Almost 90% of HIV prevention trials had 'flat' results, which may be attributable to trial design and/or implementation. The HIV prevention community must not only examine evidence from significant RCTs, but must also examine flat trials and address design and implementation issues that limit detection of an effect. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5324747 Sat, 13 Mar 2010 06:00:00 +0100 5324747 http://www.medworm.com/index.php?rid=5210280&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01280%2FHigh_prevalence_of_the_metabolic_syndrome_in.15.aspx This study describes the characteristics of the metabolic syndrome in HIV-positive patients in the Data Collection on Adverse Events of Anti-HIV Drugs study and discusses the impact of different methodological approaches on estimates of the prevalence of metabolic syndrome over time. Methods: We described the prevalence of the metabolic syndrome in patients under follow-up at the end of six calendar periods from 2000 to 2007. The definition that was used for the metabolic syndrome was modified to take account of the use of lipid-lowering and antihypertensive medication, measurement variability and missing values, and assessed the impact of these modifications on the estimated prevalence. Results: For all definitions considered, there was an increasing prevalence of the metabolic syndrome o... AIDS journals http://www.medworm.com/rss/comments.php?id=5210280 Thu, 28 Jan 2010 06:00:00 +0100 5210280 http://www.medworm.com/index.php?rid=3304275&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01280%2FErratum.24.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3304275 Thu, 28 Jan 2010 00:00:00 +0100 3304275 http://www.medworm.com/index.php?rid=5477497&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01020%2FThe_effect_of_combined_antiretroviral_therapy_on.17.aspx Objective: To estimate the effect of combined antiretroviral therapy (cART) on mortality among HIV-infected individuals after appropriate adjustment for time-varying confounding by indication. Design: A collaboration of 12 prospective cohort studies from Europe and the United States (the HIV-CAUSAL Collaboration) that includes 62 760 HIV-infected, therapy-naive individuals followed for an average of 3.3 years. Inverse probability weighting of marginal structural models was used to adjust for measured confounding by indication. Results: Two thousand and thirty-nine individuals died during the follow-up. The mortality hazard ratio was 0.48 (95% confidence interval 0.41-0.57) for cART initiation versus no initiation. In analyses stratified by CD4 cell count at baseline, the corresponding haza... AIDS journals http://www.medworm.com/rss/comments.php?id=5477497 Sat, 02 Jan 2010 06:00:00 +0100 5477497 http://www.medworm.com/index.php?rid=5163640&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01020%2FAntiretroviral_therapy_in_antenatal_care_to.11.aspx Conclusion: An integrated ART in ANC strategy doubled the proportion of treatment-eligible women initiating ART while pregnant. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5163640 Sat, 02 Jan 2010 00:00:00 +0100 5163640 http://www.medworm.com/index.php?rid=5098797&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01020%2FEfficacy_and_safety_of_TMC278_in.8.aspx Objective: TMC278 is a next-generation nonnucleoside reverse transcriptase inhibitor highly active against wild-type and nonnucleoside reverse transcriptase inhibitor-resistant HIV-1 in vitro. The week 96 analysis of TMC278-C204, a large dose-ranging study of TMC278 in treatment-naive HIV-1-infected patients, is presented. Design: Phase IIb randomized trial. Methods: Three hundred sixty-eight patients were randomized and treated with three blinded once-daily TMC278 doses 25, 75 or 150 mg, or an open-label, active control, efavirenz 600 mg once daily, all with two nucleoside reverse transcriptase inhibitors. The primary analysis was at week 48. Results: No TMC278 dose-response relationship for efficacy and safety was observed. TMC278 demonstrated potent antiviral efficacy comparable with... AIDS journals http://www.medworm.com/rss/comments.php?id=5098797 Sat, 02 Jan 2010 00:00:00 +0100 5098797 http://www.medworm.com/index.php?rid=5031419&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01020%2FRosuvastatin_versus_pravastatin_in_dyslipidemic.10.aspx Background: HIV infection and its treatment with protease inhibitors, especially when boosted with ritonavir, can cause lipid disorders. Statins, with the exception of fluvastatin, pravastatin and rosuvastatin, interact with protease inhibitor metabolism via CYP450. Pravastatin is recommended for patients with protease inhibitor-associated dyslipidemia. Rosuvastatin is the statin most effective on low-density lipoprotein cholesterol (LDL-c) in non-HIV patients. Methods: HIV-1-infected patients treated with boosted protease inhibitor were randomized to receive either rosuvastatin 10 mg/day or pravastatin 40 mg/day for dyslipidemia (LDL-c >4.1 mmol/l and triglycerides (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5031419 Sat, 02 Jan 2010 00:00:00 +0100 5031419 http://www.medworm.com/index.php?rid=5516098&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FGene_expression_before_HAART_initiation_predicts.7.aspx Conclusion: Gene expression in PBMCs can be used as biomarkers to successfully predict disease outcomes among HIV-infected individuals treated with HAART. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5516098 Fri, 01 Jan 2010 06:00:00 +0100 5516098 http://www.medworm.com/index.php?rid=4302431&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01001%2FLearning_and_doing__operational_research_and.1.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4302431 Fri, 01 Jan 2010 00:00:00 +0100 4302431 http://www.medworm.com/index.php?rid=3270492&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FRisk_factors_for_sexual_and_erectile_dysfunction.11.aspx Conclusion: There is a high prevalence of erectile dysfunction in HIV-infected men, with age and the duration of exposure to protease inhibitor being the only identifiable risk factors. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3270492 Fri, 01 Jan 2010 00:00:00 +0100 3270492 http://www.medworm.com/index.php?rid=3264471&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FIncreased_prevalence_of_subclinical_coronary.10.aspx Conclusion: Young, asymptomatic, HIV-infected men with long-standing HIV disease demonstrate an increased prevalence and degree of coronary atherosclerosis compared with non-HIV-infected patients. Both traditional and nontraditional risk factors contribute to atherosclerotic disease in HIV-infected patients. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3264471 Fri, 01 Jan 2010 00:00:00 +0100 3264471 http://www.medworm.com/index.php?rid=3249363&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FConcurrency_is_more_complex_than_it_seems.18.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3249363 Fri, 01 Jan 2010 00:00:00 +0100 3249363 http://www.medworm.com/index.php?rid=3233284&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FTransmission_networks_of_HIV_1_among_men_having.13.aspx Conclusion: From our selection of likely transmission pairs, we conclude that onward transmission of HIV-1 from infected MSM in the Netherlands happens both during and after primary infection. Transmission of resistant strains from the antiretroviral therapy-treated population is limited, but strains with resistance-related mutations have formed subepidemics. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3233284 Fri, 01 Jan 2010 00:00:00 +0100 3233284 http://www.medworm.com/index.php?rid=3225881&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FAPOBEC3G_expression_is_dysregulated_in_primary.4.aspx Conclusion: These data suggest that APOBEC3G transcription is rapidly downregulated upon HIV-1 infection. During primary infection, APOBEC3G expression levels in peripheral blood mononuclear cells do not correlate with viral loads or CD4+ T-cell counts. Genetic variation of APOBEC3G may significantly affect early HIV-1 pathogenesis, although the mechanism remains unclear and warrants further investigation. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3225881 Fri, 01 Jan 2010 00:00:00 +0100 3225881 http://www.medworm.com/index.php?rid=3221910&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FHIV_delivers_its_infectious_cargo_concealed_within.1.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3221910 Fri, 01 Jan 2010 00:00:00 +0100 3221910 http://www.medworm.com/index.php?rid=3218419&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FPolygyny_and_the_spread_of_HIV_in_sub_Saharan.16.aspx Conclusion: Existing mathematical models of concurrency are not sufficiently specific to account for the relatively benign effect of polygyny on the spread of HIV and require refinements before they are used to inform HIV prevention policies. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3218419 Fri, 01 Jan 2010 00:00:00 +0100 3218419 http://www.medworm.com/index.php?rid=3210001&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FAdenovirus_vector_specific_T_cells_demonstrate_a.5.aspx Conclusion: Ad5-specific T cells demonstrate a phenotype and proliferative potential that would support HIV infection; these results are pertinent to the findings of the Step Study and future use of Ad5 as a vaccine vector. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3210001 Fri, 01 Jan 2010 00:00:00 +0100 3210001 http://www.medworm.com/index.php?rid=3210000&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FDelivering_integrated_HIV_services__time_for_a.3.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3210000 Fri, 01 Jan 2010 00:00:00 +0100 3210000 http://www.medworm.com/index.php?rid=3209999&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FTargeting_Trojan_Horse_leukocytes_for_HIV.2.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3209999 Fri, 01 Jan 2010 00:00:00 +0100 3209999 http://www.medworm.com/index.php?rid=3201343&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2010%2F01000%2FThe_MONET_trial__darunavir_ritonavir_with_or.8.aspx Conclusions: In this study for patients with HIV RNA less than 50 copies/ml on other antiretrovirals at baseline, switching to DRV/r monotherapy showed noninferior efficacy versus triple antiretroviral therapy. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3201343 Fri, 01 Jan 2010 00:00:00 +0100 3201343 http://www.medworm.com/index.php?rid=5598877&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F11270%2FTuberculosis_among_people_with_HIV_infection_in.16.aspx Conclusions: Tuberculosis incidence among people attending UK HIV clinics is substantial, particularly among those with non-white ethnicity and low CD4 cell counts, even after starting cART. Earlier HIV diagnosis is needed in order to implement interventions to prevent tuberculosis; tuberculosis preventive therapy should be considered in addition to cART. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5598877 Fri, 27 Nov 2009 06:00:00 +0100 5598877 http://www.medworm.com/index.php?rid=3064809&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F11270%2FBreastfeeding_with_maternal_antiretroviral_therapy.5.aspx Conclusion: Maternal HAART while breastfeeding could be a promising alternative strategy in resource-limited countries. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3064809 Fri, 27 Nov 2009 00:00:00 +0100 3064809 http://www.medworm.com/index.php?rid=3037804&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F11270%2FWhen_and_how_to_use_maraviroc_in_HIV_infected.1.aspx CCR5 antagonists have recently entered the HIV armamentarium. This novel class of drugs inhibit viral entry blocking host cellular receptors, and therefore display unique mechanisms of resistance, different from other antiretroviral drugs. Maraviroc only blocks replication of R5 viruses and accordingly patients with X4 or D/M viruses do not or only marginally benefit from maraviroc therapy. Viral tropism has to be tested before considering maraviroc prescription. Phenotypic and more recently genotypic tools have been demonstrated to reliably estimate HIV-1 tropism in most cases and predict viral response. Beyond the initial approval only for antiretroviral-experienced patients, the pharmacokinetic properties and safety profile of maraviroc may support an earlier use of the drug. Studies us... AIDS journals http://www.medworm.com/rss/comments.php?id=3037804 Fri, 27 Nov 2009 00:00:00 +0100 3037804 http://www.medworm.com/index.php?rid=5423300&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F11130%2FHIV_related_stigma_and_psychological_distress__the.13.aspx Conclusion: Manifestations of HIV-related stigma vary according to setting. Certain manifestations in specific social settings impact the psychological well being of PLWHA more than others. In this study, certain experiences of stigmatization with PLWHA's families and in healthcare settings were more strongly related to psychological distress than experiences occurring in other social settings. These findings suggest that stigma reduction interventions focusing on these influential settings may benefit the psychological well being of PLWHA. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5423300 Fri, 13 Nov 2009 06:00:00 +0100 5423300 http://www.medworm.com/index.php?rid=3028061&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F11130%2FHow_much_ritonavir_is_needed_to_boost_protease.1.aspx Conclusion: It may be possible to use three protease inhibitors (saquinavir, amprenavir and darunavir) with lower doses of ritonavir. A 200/150 mg b.i.d. dose of lopinavir/ritonavir could lower costs while maintaining very similar lopinavir plasma levels to the standard dose. New pharmacoenhancer drugs may need to be used at different doses to boost different antiretrovirals. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3028061 Fri, 13 Nov 2009 00:00:00 +0100 3028061 http://www.medworm.com/index.php?rid=5251636&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F11001%2FFertility_desires_and_infection_with_the_HIV_.5.aspx Conclusion: HIV-positive individuals in the Kabarole region have a much greater desire to stop childbearing than their HIV-negative counterparts. The barriers to utilizing family planning services, as evidenced through the very low use of highly effective contraceptive methods, have to be jointly addressed by HIV/AIDS care/prevention and family planning programs. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5251636 Sun, 01 Nov 2009 05:00:00 +0100 5251636 http://www.medworm.com/index.php?rid=5080972&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F11001%2FLinking_family_planning_with_HIV_AIDS.9.aspx Conclusion: Interventions linking family planning and HIV services were generally considered feasible and effective, though overall evaluation rigor was low. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5080972 Sun, 01 Nov 2009 00:00:00 +0100 5080972 http://www.medworm.com/index.php?rid=3024345&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F10230%2FHIV_infected_persons_continue_to_lose_kidney.9.aspx Conclusion: Although ART appears to help curb kidney function decline, patients who achieved durable viral suppression continue to manifest substantial loss of eGFR. Loss of kidney function may be attributable to treatment-related factors, intermittent viremia, and traditional risk factors for kidney disease. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3024345 Fri, 23 Oct 2009 00:00:00 +0100 3024345 http://www.medworm.com/index.php?rid=5021844&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F09240%2FPersistent_HIV_RNA_shedding_in_semen_despite.15.aspx Effective antiretroviral therapy (ART) may reduce HIV sexual transmission by lowering genital HIV levels. A prospective study of men starting ART (n = 25) demonstrated rapid, substantial reductions in semen HIV RNA. However, despite an undetectable blood viral load, isolated semen HIV shedding was detected at more than one visit in 12 of 25 (48%) participants, with semen HIV RNA levels exceeding 5000 copies/ml in four of 25 (16%). Isolates were drug-sensitive, and this phenomenon was not associated with semen drug levels or regimen. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5021844 Thu, 24 Sep 2009 00:00:00 +0100 5021844 http://www.medworm.com/index.php?rid=2877765&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F09240%2FAssociation_of_abacavir_and_impaired_endothelial.11.aspx Conclusion: Endothelial function, a central mechanism in atherosclerosis and a marker of cardiovascular risk, is impaired among antiretroviral-treated patients with undetectable viral loads. Current use of abacavir was independently associated with impaired endothelial function. This finding suggests that abnormal endothelial function may underlie the clinically observed increased risk in myocardial infarction among abacavir-treated patients. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2877765 Wed, 23 Sep 2009 23:00:00 +0100 2877765 http://www.medworm.com/index.php?rid=2856697&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F09240%2FAntiretroviral_therapy_in_acute_and_recent_HIV.7.aspx Background: Antiretroviral therapy in early HIV infection may enhance outcome and viral control may be better in acute versus recent infection 24 weeks after treatment interruption. Methods: A prospective trial of treatment stratified by acute versus recent HIV-1 infection. If HIV viral load (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2856697 Wed, 23 Sep 2009 23:00:00 +0100 2856697 http://www.medworm.com/index.php?rid=2835144&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F09240%2FRenal_function_with_use_of_a_tenofovir_containing.5.aspx Conclusion: Our data are consistent with results of clinical trials, which have shown no evidence of renal toxicity when TDF is used as part of an initial regimen. Our results support the use of TDF as a component of the initial antiretroviral regimen, and suggest that the eGFR should be monitored more closely when TDF is used with a PI/r. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2835144 Wed, 23 Sep 2009 23:00:00 +0100 2835144 http://www.medworm.com/index.php?rid=2906494&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F09100%2FExpression_of_latent_human_immunodeficiency_type_1.2.aspx Conclusions: Further development of selective HDAC inhibitors as part of a clinical strategy to target persistent HIV infection is warranted. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2906494 Wed, 09 Sep 2009 23:00:00 +0100 2906494 http://www.medworm.com/index.php?rid=2856696&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F09100%2FForeskin_inflammation_is_associated_with_HIV_and.3.aspx Conclusion: Foreskin inflammation is increased with HIV and HSV-2 infections, higher HIV viral load and presence of smegma. Foreskin inflammation may have implications for HIV transmission and acquisition in uncircumcised men. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2856696 Wed, 09 Sep 2009 23:00:00 +0100 2856696 http://www.medworm.com/index.php?rid=2835143&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F09100%2FImpact_of_HAART_and_CNS_penetrating_antiretroviral.13.aspx Conclusion: A dramatic decrease in the incidence of HIV encephalopathy occurred after the introduction of HAART. The use of HAART was highly effective in reducing the incidence of HIV encephalopathy among perinatally infected children and adolescents. Effective CNS-penetrating antiretroviral regimens are important in affecting survival after diagnosis of HIV encephalopathy. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2835143 Wed, 09 Sep 2009 23:00:00 +0100 2835143 http://www.medworm.com/index.php?rid=2826165&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F09100%2FSwitching_to_second_line_antiretroviral_therapy_in.9.aspx Conclusion: In resource-limited settings, switching to second-line regimens tends to occur earlier and at higher CD4 cell counts in ART programmes with viral load monitoring compared with programmes without viral load monitoring. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2826165 Wed, 09 Sep 2009 23:00:00 +0100 2826165 http://www.medworm.com/index.php?rid=2783895&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F09100%2FCharacterization_of_virologic_failure_patients_on.5.aspx Conclusion: In treatment-experienced, LPV-naive patients, the overall virologic failure rate in the DRV/r arm was low and was associated with limited resistance development. These findings showed that the use of DRV/r in earlier lines of treatment was less likely to lead to cross-resistance to other protease inhibitors compared with LPV/r. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2783895 Wed, 09 Sep 2009 23:00:00 +0100 2783895 http://www.medworm.com/index.php?rid=5423301&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F08240%2FShort_term_and_long_term_risk_of_tuberculosis.11.aspx Conclusion: Updated CD4 cell counts were the dominant predictor of TB risk during ART in this low-resource setting. Among those with baseline CD4 cell counts less than 200 cells/[mu]l, the excess adjusted risk of TB during early ART was consistent with 'unmasking' of disease missed at baseline screening. TB incidence rates at CD4 cell counts of 200-500 cells/[mu]l remained high and adjunctive interventions are required. TB prevention would be improved by ART policies that minimized the time patients spend with CD4 cell counts below a threshold of 500 cells/[mu]l. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=5423301 Mon, 24 Aug 2009 05:00:00 +0100 5423301 http://www.medworm.com/index.php?rid=2672845&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F07310%2FHepatitis_C_virus_infections_among_HIV_infected.1.aspx Conclusion: We found a high and increasing HCV prevalence in HIV-infected MSM. Though not statistically significant, this trend, and the relatively large proportion of acute infections suggest ongoing transmission of HCV in HIV-positive MSM. Regardless of IDU, rough sexual techniques and use of recreational drugs were associated with HCV-infection; phylogenetic analysis supported sexual transmission. Targeted prevention, like raising awareness and routine testing, is needed to stop the further spread among HIV-infected MSM, and to prevent possible spillover to HIV-negative MSM. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2672845 Thu, 30 Jul 2009 23:00:00 +0100 2672845 http://www.medworm.com/index.php?rid=2669120&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F07170%2FEffects_of_switching_from_lopinavir_ritonavir_to.7.aspx Conclusion: Switching from LPV/r to ATV/r significantly increases glucose uptake by muscle, decreases abdominal visceral adipose tissue, improves lipid parameters, and decreases fasting glucose over 6 months. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2669120 Thu, 16 Jul 2009 23:00:00 +0100 2669120 http://www.medworm.com/index.php?rid=2603939&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F07170%2FFirst_line.9.aspx Conclusion: BMD in both femoral neck and lumbar spine decreased rapidly after initiation of cART, in parallel to an increase in bone turnover. The greater bone loss in the ZDV/3TC/LPV/r group compared to the NVP/LPV/r group suggests that ZDV/3TC contributes to this process. The PTH increase does not explain this greater bone loss. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2603939 Thu, 16 Jul 2009 11:02:20 +0100 2603939 http://www.medworm.com/index.php?rid=2578325&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F07170%2FMetabolic_bone_disease_in_HIV_infection.2.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2578325 Wed, 08 Jul 2009 11:05:06 +0100 2578325 http://www.medworm.com/index.php?rid=2565160&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F07170%2FData_are_lacking_for_quantifying_HIV_transmission.17.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2565160 Sun, 05 Jul 2009 11:04:36 +0100 2565160 http://www.medworm.com/index.php?rid=2565159&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F07170%2FSexual_transmission_of_HIV_according_to_viral_load.13.aspx Conclusion: Studies of heterosexual discordant couples observed no transmission in patients treated with ART and with viral load below 400 copies/ml, but data were compatible with one transmission per 79 person-years. Further studies are needed to better define the risk of HIV transmission from patients on ART. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2565159 Sun, 05 Jul 2009 11:04:36 +0100 2565159 http://www.medworm.com/index.php?rid=2565158&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F07170%2FImpact_of_combination_antiretroviral_therapy_on.8.aspx Conclusion: Antiretroviral regimens with good CNS penetration, as assessed by CPE rank, are more effective in controlling CSF (and presumably CNS) viral replication than regimens with poorer penetration. In this study, antiretrovirals with good CNS penetration were associated with poorer neurocognitive performance. A larger controlled trial is required before any conclusions regarding the influence of specific antiretrovirals on neurocognitive performance should be made. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2565158 Sun, 05 Jul 2009 11:04:36 +0100 2565158 http://www.medworm.com/index.php?rid=2565157&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F07170%2FUnprotected_sex_between_HIV_infected_partners.1.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2565157 Sun, 05 Jul 2009 11:04:36 +0100 2565157 http://www.medworm.com/index.php?rid=2490917&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F06190%2FEarly_antiretroviral_treatment_prevents_the.1.aspx Conclusion: Early antiretroviral treatment prevents central nervous system dysfunction by decreasing brain viral load and interferon-[alpha] levels, which can have a profound impact over the course of infection. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2490917 Thu, 18 Jun 2009 23:00:00 +0100 2490917 http://www.medworm.com/index.php?rid=2479878&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2002%2F16004%2FDenial_and_defiance__a_socio_political_analysis_of.7.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479878 Wed, 17 Jun 2009 02:34:08 +0100 2479878 http://www.medworm.com/index.php?rid=2479881&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F06010%2FRole_of_viral_replication%2C_antiretroviral_therapy%2C.3.aspx Conclusions: Increased atherosclerosis with HIV infection can occur in the absence of antiretroviral therapy, detectable viremia, or overt immunodeficiency. Chronic inflammation - which is higher in controllers than in HIV-uninfected persons - may account for early atherosclerosis in these patients. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479881 Mon, 01 Jun 2009 04:00:00 +0100 2479881 http://www.medworm.com/index.php?rid=2479877&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F06010%2FAntiretroviral_medication_adherence_and_the.1.aspx Conclusion: Knowledge of class-specific adherence-resistance relationships may help clinicians and patients tailor therapy to match individual patterns of adherence in order to minimize the development of resistance at failure. In addition, this information may guide the selection of optimal drug combinations and regimen sequences to improve the durability of antiretroviral therapy. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479877 Mon, 01 Jun 2009 04:00:00 +0100 2479877 http://www.medworm.com/index.php?rid=3692997&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F06010%2FAnal_human_papillomavirus_infection_is_associated.11.aspx Conclusion: Anal HPV infection is independently associated with HIV acquisition. Studies that incorporate high-resolution anoscopy to more accurately identify HPV-associated disease are needed to determine the relationship between HPV-associated disease and HIV seroconversion. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3692997 Sun, 31 May 2009 23:00:00 +0100 3692997 http://www.medworm.com/index.php?rid=3656498&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F06010%2FTrends_in_three_decades_of_HIV_AIDS_epidemic_in.12.aspx Conclusion: Our analysis indicated that, thus far, the 1990s was the most severe era of HIV/AIDS epidemic in Thailand with two HIV incidence peaks. A drop in new infections led to a decrease in recent AIDS incidence, and this tendency is likely to remain unchanged until 2011, if not further. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3656498 Sun, 31 May 2009 23:00:00 +0100 3656498 http://www.medworm.com/index.php?rid=2479890&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FHAART_is_associated_with_lower_hepatic.12.aspx Conclusion: Use of HAART was associated with lower levels of necroinflammatory activity. Necroinflammatory activity was strongly associated with higher fibrosis scores. These results suggest that HAART might decrease hepatitis C activity in HIV-HCV-coinfected patients with CD4 cell count of more than 350 cells/[mu]l. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479890 Fri, 15 May 2009 04:00:00 +0100 2479890 http://www.medworm.com/index.php?rid=2479889&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FEffects_of_long_term_testosterone_administration.10.aspx Objective: Androgen deficiency is common in HIV-infected women. We investigated the long-term effects of transdermal testosterone on body composition, bone mineral density, quality of life, and safety. Design: Twenty-five HIV-infected women with free testosterone below the median ( (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479889 Fri, 15 May 2009 04:00:00 +0100 2479889 http://www.medworm.com/index.php?rid=2479888&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FThe_global_strategy_to_eliminate_HIV_infection_in.14.aspx Conclusion: Scaling up PMTCT will require more funds than currently available in many countries, but human resources appear to be a greater bottleneck than funding. We suggest that human resource capacity be assessed when increased funds for PMTCT are requested. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479888 Fri, 15 May 2009 04:00:00 +0100 2479888 http://www.medworm.com/index.php?rid=2479885&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FTen_year_incidence_and_risk_factors_of_bone.18.aspx In the ANRS CO8 APROCO-COPILOTE cohort of patients treated with combination antiretroviral therapy since 1997-1999, the incidence density of bone fractures was 3.3 for 1000 patient-years [95% confidence interval (CI) = 2.0-4.6]. The rate was 2.9-fold (95% CI = 1.3-6.5) higher among patients with excessive alcohol consumption and 3.6-fold (95% CI = 1.6-8.1) higher in those with hepatitis C virus (HCV) coinfection. Specific monitoring of HCV/HIV-coinfected patients and active promotion of alcohol cessation should be recommended for the prevention of bone fractures. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479885 Fri, 15 May 2009 04:00:00 +0100 2479885 http://www.medworm.com/index.php?rid=2479883&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FA_message_from_the_publisher.1.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479883 Fri, 15 May 2009 04:00:00 +0100 2479883 http://www.medworm.com/index.php?rid=2479882&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FNon_0002030_defining_malignancies_in_HIV_infected.2.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479882 Fri, 15 May 2009 04:00:00 +0100 2479882 http://www.medworm.com/index.php?rid=2479876&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FHIV_increases_markers_of_cardiovascular_risk_.8.aspx Conclusion: Plasma levels of several inflammatory, anti-inflammatory and endothelial activation markers of cardiovascular disease are associated with HIV-RNA replication. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479876 Fri, 15 May 2009 04:00:00 +0100 2479876 http://www.medworm.com/index.php?rid=4325252&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FHeterogeneous_neutralizing_antibody_and.4.aspx Conclusion: There was no single anti-HIV-1 antibody specificity that was a clear correlate of immunity in controllers. Rather, for most antibody types, controllers had the same or lower levels of nAbs than viremic individuals, with the possible exception of ADCC antibodies. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4325252 Fri, 15 May 2009 00:00:00 +0100 4325252 http://www.medworm.com/index.php?rid=4299328&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FTrichosporon_asahii_infection_in_an_HIV_positive.21.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4299328 Fri, 15 May 2009 00:00:00 +0100 4299328 http://www.medworm.com/index.php?rid=4006249&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FUpdated_outcomes_of_partner_notification_for_human.19.aspx An evaluation of HIV-partner notification demonstrated its effectiveness in identifying new cases of HIV infection in San Francisco. Findings suggested that health departments should consider focusing efforts on reducing the time between diagnosis and interview. Such data are critical for the prioritization of HIV-case-finding activities and enable local health departments to measure the costs of partner services, as well as identify areas for quality improvement. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4006249 Fri, 15 May 2009 00:00:00 +0100 4006249 http://www.medworm.com/index.php?rid=3966911&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FDetection_of_tuberculosis_in_HIV_infected_children.11.aspx Conclusion: ELISPOT is more sensitive than TST for the detection of active TB in HIV-infected children. However, the sensitivity of current ELISPOT assays is not sufficiently high to be used as a rule out test for TB. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3966911 Fri, 15 May 2009 00:00:00 +0100 3966911 http://www.medworm.com/index.php?rid=3926264&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F05150%2FSustained_release_of_microbicides_by_newly.6.aspx Conclusion: The intravaginal rings described here are capable of efficacious drug delivery. Incorporation of several antiretroviral agents, including betulinol derivatives, which act at multiple levels of the HIV life cycle, may provide a synergistic effect to achieve higher efficacy on the inhibition of HIV infection. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3926264 Fri, 15 May 2009 00:00:00 +0100 3926264 http://www.medworm.com/index.php?rid=2479887&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F04270%2FGreater_decrease_in_bone_mineral_density_with.9.aspx Objective: To evaluate the change in bone mineral density (BMD) at specific sites in patients initiating antiretroviral therapy in a substudy of the ANRS 121 trial. Methods: Antiretroviral-naive patients were randomized (2: 1: 1) into three treatment strategy arms: a nonnucleoside reverse transcriptase inhibitor (NNRTI) and a boosted protease inhibitor (PI/r), a PI/r and two nucleoside reverse transcriptase inhibitors (NRTIs) or an NNRTI and NRTIs. Hip and lumbar spine standardized BMD were evaluated at baseline and week 48 by dual X-ray absorptiometry by a central reading laboratory. Results: Seventy-one patients were enrolled: 36 in the PI/r and NNRTI, 19 in the PI/r and NRTIs and 16 in the NNRTI and NRTIs arms. Baseline characteristics were [median (interquartile range)]: male (77%), ag... AIDS journals http://www.medworm.com/rss/comments.php?id=2479887 Mon, 27 Apr 2009 04:00:00 +0100 2479887 http://www.medworm.com/index.php?rid=2479886&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F04270%2FClinical_experience_with_the_combined_use_of.14.aspx Thirty-four patients treated concomitantly with lopinavir/ritonavir and rifampicin were evaluated. Overall, only 15% used the recommended increased dose of lopinavir/ritonavir. Of patients on a nonadjusted dose of lopinavir/ritonavir, 67% had a subtherapeutic lopinavir plasma concentration and 38% had a detectable viral load. Forty percent of patients on an increased dose of lopinavir/ritonavir prematurely stopped the drug combination because of adverse events. Combined use of lopinavir/ritonavir and rifampicin is challenging as it implies balancing between suboptimal efficacy and toxicity. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479886 Mon, 27 Apr 2009 04:00:00 +0100 2479886 http://www.medworm.com/index.php?rid=2479884&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F04270%2FIs_it_smart_to_continue_to_study_treatment.2.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479884 Mon, 27 Apr 2009 04:00:00 +0100 2479884 http://www.medworm.com/index.php?rid=2479880&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F04270%2FEtravirine_raltegravir%2C_a_marked_interaction_in.17.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479880 Mon, 27 Apr 2009 04:00:00 +0100 2479880 http://www.medworm.com/index.php?rid=2479879&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F04270%2FCD4_cell_guided_scheduled_treatment_interruptions.7.aspx Conclusion: The two strategies may be considered clinically equivalent. CD4 cell-guided STIs seem a possible alternative for chronically infected individuals responding to HAART provided that CD4 cell decrements would be steadily maintained above a safe threshold. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2479879 Mon, 27 Apr 2009 04:00:00 +0100 2479879 http://www.medworm.com/index.php?rid=3963312&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F04270%2FTolerance_and_viral_resistance_after_single_dose.10.aspx Conclusion: The TDF/FTC combination was well tolerated in delivering women and exposed newborns. Nevirapine viral resistance appears to have been avoided by the intrapartum and 7-day postpartum TDF/FTC regimen. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=3963312 Mon, 27 Apr 2009 00:00:00 +0100 3963312 http://www.medworm.com/index.php?rid=4325253&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fjournals.lww.com%2Faidsonline%2FFulltext%2F2009%2F03270%2FPharmacokinetics_of_darunavir%2C_etravirine_and.15.aspx No abstract available (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=4325253 Fri, 27 Mar 2009 00:00:00 +0100 4325253 http://www.medworm.com/index.php?rid=2264366&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fwww.aidsonline.com%2Fpt%2Fre%2Faids%2Fabstract.00002030-200903270-00016.htm Page: 742DOI: 10.1097/QAD.0b013e32832914a3Authors: van Luin, Matthijs a,b; Brouwer, Anne-Marie c; van der Ven, Andre c; de Lange, Wiel d; van Schaik, Ron HN e; Burger, David M a (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2264366 Sun, 15 Mar 2009 04:14:07 +0100 2264366 http://www.medworm.com/index.php?rid=2264365&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fwww.aidsonline.com%2Fpt%2Fre%2Faids%2Fabstract.00002030-200903270-00015.htm Page: 740DOI: 10.1097/QAD.0b013e328328f79dAuthors: Giguere, Pierre a,b; la Porte, Charles b,c,d; Zhang, Guijun b; Cameron, Bill b,c,d (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2264365 Sun, 15 Mar 2009 04:14:07 +0100 2264365 http://www.medworm.com/index.php?rid=2264364&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fwww.aidsonline.com%2Fpt%2Fre%2Faids%2Fabstract.00002030-200903270-00014.htm Page: 740DOI: 10.1097/QAD.0b013e328327727bAuthors: Rollins, Nigel C a; Becquet, Renaud b,c,d; Bland, Ruth M b,e; Coutsoudis, Anna a; Coovadia, Hoosen M f; Newell, Marie-Louise b,g (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2264364 Sun, 15 Mar 2009 04:14:07 +0100 2264364 http://www.medworm.com/index.php?rid=2264363&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fwww.aidsonline.com%2Fpt%2Fre%2Faids%2Fabstract.00002030-200903270-00013.htm Page: 739DOI: 10.1097/QAD.0b013e328325a4bdAuthors: Papendorp, Stephan Gerardus; van den Berk, Guido E (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2264363 Sun, 15 Mar 2009 04:14:07 +0100 2264363 http://www.medworm.com/index.php?rid=2264362&cid=s_34308_20_f&fid=34308&url=http%3A%2F%2Fwww.aidsonline.com%2Fpt%2Fre%2Faids%2Fabstract.00002030-200903270-00012.htm Page: 731DOI: 10.1097/QAD.0b013e328326f77fAuthors: Keller, Marina; Lu, Ying; Lalonde, Richard G; Klein, Marina B (Source: AIDS) AIDS journals http://www.medworm.com/rss/comments.php?id=2264362 Sun, 15 Mar 2009 04:14:07 +0100 2264362