MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Acta Diabetologica' source. Wed, 08 Feb 2012 15:08:48 +0100 http://www.medworm.com/index.php?rid=5667686&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvmnp25p228352501%2F In conclusion, serum RBP-4 and IGF-I/IGFBP-3 molar ratio but not LCN-2 were prominently elevated with poor glycemic control rather than obesity in T2DM patients. Whereas, declining β-cell function is associated with elevation of serum RBP-4, LCN-2 as well as IGF-I/IGFBP-3 molar ratio. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00592-012-0373-6Authors Hala O. El-Mesallamy, Biochemistry Department, Faculty of Pharmacy, Ain-Shams University, Abassia, Cairo, 11566 EgyptNadia M. Hamdy, Biochemistry Department, Faculty of Pharmacy, Ain-Shams University, Abassia, Cairo, 11566 EgyptAl-aliaa M. Sallam, Biochemistry Department, Faculty of Pharmacy, Ain-Shams University, Abassia, Cairo, 11566 Egypt Journal Acta DiabetologicaOnline ISSN 1432-5233Print I... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5667686 Fri, 03 Feb 2012 17:53:08 +0100 5667686 http://www.medworm.com/index.php?rid=5667687&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fru1r6r7h4142061w%2F Abstract   31P-magnetic resonance spectroscopy (31P-MRS) is a non-invasive tool to study high-energy phosphate (HEP) metabolism. We evaluate whether 31P-MRS can detect early changes in kidney HEP metabolism during a 6-month trial with Valsartan. Twenty consecutive stable and normotensive kidney-transplanted patients were enrolled. Nine of them received short-term low-dose Valsartan treatment (80 mg/day) for 6 months, while 11 controls received no medication. Kidney HEP metabolism was evaluated both at baseline and after treatment by 31P-MRS with a 1.5 T system (Gyroscan Intera Master 1.5 MR System; Philips Medical Systems, Best, The Netherlands). Valsartan-treated patients (n = 9) showed a significant increase in β-ATP/Pi ratio, a marker of kidney H... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5667687 Thu, 02 Feb 2012 17:54:30 +0100 5667687 http://www.medworm.com/index.php?rid=5667688&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F93w21025l1628221%2F In conclusion, normalizing islet volume by IE overestimated the tissue volume, which may lead to erroneous results. Normalizing by cell number is a more accurate method to quantify tissue amounts used in islet transplantation and research. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s00592-012-0375-4Authors Han-Hung Huang, Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, MS 2002, 3901 Rainbow Blvd., Kansas City, KS 66160, USAKarthik Ramachandran, Bioengineering Graduate Program, University of Kansas, School of Engineering, Lawrence, KS 66045, USALisa Stehno-Bittel, Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, MS 2002, 3901 Rainbow Blvd., Kansas City, KS ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5667688 Thu, 02 Feb 2012 17:54:28 +0100 5667688 http://www.medworm.com/index.php?rid=5660397&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F04u6524002324jq2%2F Abstract  Early intensive therapy in type 2 diabetes can prevent complications. Nevertheless, metabolic control is often sub-optimal in newly diagnosed patients. This web-based survey aimed to evaluate opinions of physicians about treatment, priorities, and barriers in the care of patients first referred to diabetes clinics. Data on physician attitudes toward therapeutic preferences for two clinical case models (same clinical profile, except HbA1c levels of 8.6 and 7.3% at the first access, respectively) were collected. Participants were asked to rank from 1 (most important) to 6 (least important) a list of priorities and barriers associated with the care of new patients. Overall, 593 physicians participated. In both case models, metformin and education were primary options... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5660397 Tue, 31 Jan 2012 16:45:12 +0100 5660397 http://www.medworm.com/index.php?rid=5648768&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe087502013674208%2F Abstract  Neuropathy, one of the major reasons of morbidity in diabetes mellitus (DM), is associated with prediabetic conditions as well as DM. The present study aims to compare phrenic and peripheral nerves in prediabetic, diabetic patients and healthy controls. A total of 37 diabetic, 40 prediabetic patients and 18 healthy controls were enrolled in the study. All subjects underwent conventional sensory and motor nerve conduction studies. Bilateral phrenic and peripheric nerve conduction studies were performed. In both right and left phrenic nerves, the amplitudes were lower in prediabetic and diabetic patients than control subjects, respectively (p: 0.005 and p: 0.001). Both of the phrenic nerve conductions were altered similarly. The results of our study demonstrate that ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5648768 Fri, 27 Jan 2012 17:56:01 +0100 5648768 http://www.medworm.com/index.php?rid=5648769&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6j60l021uw02v661%2F Abstract  We assessed the efficacy of noninsulin antidiabetic medications used in current clinical practice (metformin, sulfonylureas, α-glucosidase inhibitors, thiazolidinediones, glinides, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 agonists) to reach the HbA1c target <7% in people with type 2 diabetes. MEDLINE, EMBASE, and the Cochrane CENTRAL were searched from inception through April 2011 for randomized controlled trials (RCTs) involving noninsulin antidiabetic drugs. RCTs had to report the effect of any diabetes medication on the HbA1c levels, to include at least 30 subjects in every arm of the study, and to last at least 12 weeks. Data were summarized across studies using random-effects meta-regression. We found 137 RCTs with 205 arms and 39,8... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5648769 Fri, 27 Jan 2012 17:56:00 +0100 5648769 http://www.medworm.com/index.php?rid=5638930&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq1xl7625t2060641%2F In this study, we investigated the interrelationship between BID and anthropometric, laboratory and clinical parameters. A total of 681 type 2 diabetic patients, treated with bedtime insulin in association with other antidiabetic drugs (preprandial insulin and/or oral agents), were studied. Anthropometric, clinical and biochemical parameters, as well as micro- and macrovascular complications, were evaluated. Non-alcoholic fatty liver disease (NAFLD) was assessed by liver ultrasound. BID was titrated to achieve a fasting blood glucose target of ≤6.7 mmol/L (120 mg/dL). In the multivariate analysis, BID was significantly associated with waist circumference (p = 0.04) and the insulin treatment duration (p = 0.004) as the type of insulin treatment (“basal... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5638930 Tue, 24 Jan 2012 18:14:13 +0100 5638930 http://www.medworm.com/index.php?rid=5620660&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3032870383730163%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00592-011-0363-0Authors Andrea E. Scaramuzza, Department of Paediatrics, “Luigi Sacco Hospital”, University of Milano, Via G.B. Grassi 74, 20157 Milan, ItalyMarco Morelli, Department of Paediatrics, “Luigi Sacco Hospital”, University of Milano, Via G.B. Grassi 74, 20157 Milan, ItalyMaurizio Rizzi, Respiratory Medicine, Luigi Sacco Hospital, University of Milano, Via G.B. Grassi 74, 20157 Milan, ItalySimona Borgonovo, Department of Paediatrics, “Luigi Sacco Hospital”, University of Milano, Via G.B. Grassi 74, 20157 Milan, ItalyAlessandra De Palma, Department of Paediatrics, “Luigi Sacco Hospital”, University of Milano, Via G.B. Grassi 74, 20157 Milan, ItalyChiara Mameli, Department of Paediatrics, “Luigi... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5620660 Tue, 17 Jan 2012 07:09:44 +0100 5620660 http://www.medworm.com/index.php?rid=5620659&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb631783683354837%2F Abstract  Post-transplant diabetes mellitus represents an important complication of prolonged immunosuppressive treatment after solid organ transplantation. The immunosuppressive toxicity, responsible for a persistent impairment of glucose metabolism in pancreatic islet-transplanted patients, is mainly attributed to calcineurin inhibitors and steroids, while other immunosuppressive molecules (azathioprine and mycophenolic acid, MPA) are considered not to have a toxic effect. In the present study, in vitro effects of MPA have been investigated in mouse beta-cell lines (βTC-1 and βTC-6) and in purified human pancreatic islets. βTC-1, βTC-6, and human pancreatic islets were exposed to various concentrations of MPA for different times. Consequently, we evaluated the viabili... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5620659 Tue, 17 Jan 2012 07:09:44 +0100 5620659 http://www.medworm.com/index.php?rid=5572572&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F84g0u746x3778506%2F Abstract  In the present article, we propose the perspective that abnormal glutamate homeostasis might contribute to diabetes pathogenesis. Previous reports and our recent data indicate that chronically high extracellular glutamate levels exert direct and indirect effects that might participate in the progressive loss of β-cells occurring in both T1D and T2D. In addition, abnormal glutamate homeostasis may impact all the three accelerators of the “accelerator hypothesis” and could partially explain the rising frequency of T1D and T2D. Content Type Journal ArticleCategory Review ArticlePages 1-17DOI 10.1007/s00592-011-0364-zAuthors Alberto M. Davalli, Diabetes and Endocrinology Unit, Department of Internal Medicine, San Raffaele Scientific Institute, 20132 Milan, I... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5572572 Wed, 04 Jan 2012 16:59:49 +0100 5572572 http://www.medworm.com/index.php?rid=5572573&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9ur5w8t1h7745l45%2F Abstract  Adipokines are known to play a fundamental role in the etiology of obesity, that is, in the impaired balance between increased feeding and decreased energy expenditure. While the adipokine-induced changes of insulin resistance in obese diabetic and nondiabetic subjects are well known, the possible role of fat source in modulating insulin sensitivity (IS) remains controversial. The aim of our study was to explore in overweight type 2 diabetic patients (T2DM) with metabolic syndrome IS in different energy storage conditions (basal and dynamic) for relating it to leptin and adiponectin. Sixteen T2DM (5/11 F/M; 59 ± 2 years; 29.5 ± 1.1 kg/m2) and 16 control (CNT 5/11; 54 ± 2; 29.1 ± 1.0) underwent an oral glucose to... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5572573 Wed, 04 Jan 2012 07:00:27 +0100 5572573 http://www.medworm.com/index.php?rid=5572574&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8k8550525k102052%2F Abstract  Type 2 diabetes is associated with risk of cancer. Hyperinsulinemia and insulin resistance may be the link with cancer, but whether this is independent of the diabetes status, obesity/visceral obesity and metabolic syndrome is uncertain and the present study wanted to address this issue. Fifteen-year all-cause, CVD and cancer mortality data were obtained through the Regional Health Registry in 2,011 out of 2,074 Caucasian middle-aged individuals of the Cremona Study, a population study on the prevalence of diabetes mellitus in Italy in which anthropometric and metabolic characteristics were collected. During the 15-year observation period, 495 deaths were registered: 221 CVD related and 180 cancer related. Age and sex were independently associated with all-cause, ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5572574 Wed, 04 Jan 2012 07:00:26 +0100 5572574 http://www.medworm.com/index.php?rid=5560740&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl83l2626013m8660%2F Abstract  The consumption of foods containing trans fatty acids (TFA), especially those produced by food industries, induces pleiotropic negative effects on health. Therefore, it is important to assess the amount of TFA consumed, especially in age groups more exposed to the consumption of TFA-containing foods. The present pilot study evaluates TFA intake in 54 young people with and without type 1 diabetes (29 young subjects with type 1 diabetes and 25 healthy subjects) through both dietary records (7-day food record) and the measurement of TFA levels in serum phospholipids, a possibly more objective marker of TFA intake. The comparison between the two groups was made by the student t test for independent samples. The intake of synthetic TFA was low in both groups (type 1 dia... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5560740 Fri, 30 Dec 2011 07:09:01 +0100 5560740 http://www.medworm.com/index.php?rid=5560741&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4l8ml95307472524%2F Content Type Journal ArticleCategory EditorialPages 1-2DOI 10.1007/s00592-011-0367-9Authors Andrea E. Scaramuzza, Department of Paediatrics, University of Milano, “Luigi Sacco Hospital”, via G.B. Grassi 74, 20157 Milan, ItalyGian Vincenzo Zuccotti, Department of Paediatrics, University of Milano, “Luigi Sacco Hospital”, via G.B. Grassi 74, 20157 Milan, Italy Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5560741 Fri, 30 Dec 2011 07:08:59 +0100 5560741 http://www.medworm.com/index.php?rid=5544844&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr58633kt461542x6%2F This study suggests that islet-associated autoimmunity may be involved in and contribute to the development of F1D. Pregnant women may be PF high-risk population, and the prognosis for the fetus is extremely poor in PF patients. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00592-011-0362-1Authors Shuoming Luo, Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, 139 Renmin Zhong Road, Changsha, 410011 ChinaZhenyi Zhang, Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, 139 Renmin Zhong Road, Changsha, 410011 ChinaXia Li, Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, 139 ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5544844 Thu, 22 Dec 2011 12:50:21 +0100 5544844 http://www.medworm.com/index.php?rid=5544845&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp882827778427625%2F Abstract  Self-monitoring of blood glucose (SMBG) is a core component of diabetes management. However, the International Diabetes Federation recommends that SMBG be performed in a structured manner and that the data are accurately interpreted and used to take appropriate therapeutic actions. We designed a study to evaluate the impact of structured SMBG on glycemic control in non-insulin-treated type 2 diabetes (T2DM) patients. The Prospective, Randomized Trial on Intensive SMBG Management Added Value in Non-insulin-Treated T2DM Patients (PRISMA) is a 12-month, prospective, multicenter, open, parallel group, randomized, and controlled trial to evaluate the added value of an intensive, structured SMBG regimen in T2DM patients treated with oral agents and/or diet. One thousand... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5544845 Wed, 21 Dec 2011 20:06:44 +0100 5544845 http://www.medworm.com/index.php?rid=5525509&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F79v2k122v040h73j%2F Abstract  Diabetes mellitus is associated with oxidative injury to the vasculature. Here, the link between oxidative stress and ultrastructural changes in the hepatic microcirculation was investigated as well as the effects of a synthetic antioxidant, tert-butyl bisphenol (tBP). The study focused on the impact of experimental diabetes on liver sinusoidal endothelial cell (LSEC) fenestrations, which are pores in the liver endothelium that facilitate substrate transfer between blood and hepatocytes. Adult male rats were rendered diabetic using streptozotocin (60 mg/kg) and administered 1–2 IU insulin daily. After 8 weeks, animals received either 100 mg/kg tBP or vehicle alone, on 2 consecutive days. Livers were harvested 24 h later under isofluorane a... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5525509 Mon, 19 Dec 2011 16:51:27 +0100 5525509 http://www.medworm.com/index.php?rid=5505753&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn47t3466477n1463%2F Abstract  Coronary arterial disease (CAD) is common in diabetic patients, and endothelial progenitor cells (EPCs) are considered a surrogate marker for CAD, but controversies regarding this issue still remain. We investigated the potential clinical role of EPCs during coronary screening in asymptomatic type 2 diabetic patients screened with cardiovascular magnetic resonance (CMR). A total of 100 asymptomatic type 2 diabetic subjects (51 men and 49 women) were enrolled. Clinical and laboratory parameters, including EPCs (CD34+/CD133+/VEGFR-2+) count, were evaluated and CMR was performed. A total of 51 patients [silent myocardial infarction (n = 3), inducible ischemia (n = 11), suspected CAD (n = 37)] had abnormal finding on CMR. Of the 20 patients... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5505753 Mon, 12 Dec 2011 17:16:10 +0100 5505753 http://www.medworm.com/index.php?rid=5505752&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx951224345kt2251%2F Abstract  A 59-year old man with moderate and stable psoriasis through 15 years was admitted to our Department with inadequately controlled type 2 diabetes. Treatment was initiated with the glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide. The patient experienced marked improvement in his psoriasis immediately after the start of liraglutide treatment. Itching stopped within days, scaling was reduced and spots of normal skin emerged. After 3 months, psoriasis was still improving. Excellent glycaemic control and a weight loss of approximately 8 kg over 3 months were moreover obtained. The patient had previously been well controlled in his diabetes without improvement in psoriasis, and the effect of liraglutide on psoriasis started before weight... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5505752 Mon, 12 Dec 2011 17:16:10 +0100 5505752 http://www.medworm.com/index.php?rid=5458408&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy7196h5p08225773%2F Abstract  Polymeric nanoparticles are widely used as targeted carriers for biomacromolecules. In this paper, modified gelatin nanoparticles were prepared and their feasibility as insulin pulmonary administration system was investigated. d,l-glyceraldehyde and poloxamer 188 were used for gelatin nanoparticle preparation. Novel water-in-water emulsion technique was used to prepare insulin-loaded nanoparticles. Morphological examination of insulin-loaded nanoparticles was carried out using scanning electron microscopy (SEM). Intratracheal instillation of insulin-loaded nanoparticles was performed to evaluate animal hypoglycemic effect. With fluorescence labeling of insulin, alveolar deposition and absorption of insulin-loaded nanoparticles were investigated. Histological change... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5458408 Mon, 28 Nov 2011 16:52:06 +0100 5458408 http://www.medworm.com/index.php?rid=5449945&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5088612473071075%2F Abstract  Post-prandial hyperglycemia is considered a relevant therapeutic target in type 2 diabetic patients, and it could represent per se an independent risk factor for diabetic complications. Aim of the present systematic review is to collect and summarize evidence from observational studies on the relationship between post-prandial glucose (PPG) and cardiovascular or microvascular disease in patients with diabetes. An extensive search of Medline (any date up to December 31, 2010) was performed for all longitudinal epidemiological studies with a cohort design. The following endpoints were taken into consideration: death from any cause; cardiovascular death and micro- and macrovascular complications. The number of epidemiological studies assessing the relationship betwee... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5449945 Thu, 24 Nov 2011 17:51:47 +0100 5449945 http://www.medworm.com/index.php?rid=5449946&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy0745468p05n4115%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00592-011-0354-1Authors Jun Murai, Department of Internal Medicine, Kinki Central Hospital, Hyogo, Kuruma-zuka 3-1, Itami, Hyogo, 664-8533 JapanMasafumi Koga, Department of Internal Medicine, Kinki Central Hospital, Hyogo, Kuruma-zuka 3-1, Itami, Hyogo, 664-8533 JapanHiroshi Saito, Department of Internal Medicine, Kinki Central Hospital, Hyogo, Kuruma-zuka 3-1, Itami, Hyogo, 664-8533 JapanMikio Mukai, Department of Internal Medicine, Kinki Central Hospital, Hyogo, Kuruma-zuka 3-1, Itami, Hyogo, 664-8533 JapanSoji Kasayama, Department of Medicine, Nissay Hospital, Osaka, Japan Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5449946 Tue, 22 Nov 2011 17:57:46 +0100 5449946 http://www.medworm.com/index.php?rid=5441596&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq6375127x56k5048%2F Abstract  We assessed the presence of lung dysfunction in children with type 1 diabetes, evaluated as reduced diffusing capacity of the lung for carbon monoxide (DLCO), and its components: membrane diffusing capacity (DM) and pulmonary capillary blood volume (Vc). A total of 42 children, aged 15.6 ± 3.8 years, with type 1 diabetes for 8.3 ± 5.5 years, and 30 healthy age and sex-matched peers were recruited for the study. Lung volumes and spirometric dynamic parameters were assessed by plethysmography. Single-breath DLCO was measured according to international recommendation. DM and Vc volume were calculated. Lung volumes were significantly reduced in young patients with type 1 diabetes when compared to controls. Moreover, DLCO was reduced in patients co... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5441596 Mon, 21 Nov 2011 18:10:10 +0100 5441596 http://www.medworm.com/index.php?rid=5432219&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyh1g42gm7lp3x788%2F This study was designed as an open-label, randomized, controlled trial of 3-month duration. Women with newly diagnosed type 2 diabetes were studied. Twenty-eight of the 55 eligible participants were randomly assigned to receive rosiglitazone (4 mg/d). Twenty-seven patients with diabetes matched for age and body mass index served as controls on diet alone. We evaluated the effects of 3 months of rosiglitazone treatment on fasting peptide YY3–36 and ghrelin levels, and anthropometric measurements. The 3-month administration of rosiglitazone reduced fasting plasma peptide YY3–36 levels by 25%, the between-group difference was statistically significant. No effect of this thiazolidinedione compound on fasting ghrelin concentrations was observed at the end of study. The ghrel... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5432219 Fri, 18 Nov 2011 17:35:01 +0100 5432219 http://www.medworm.com/index.php?rid=5409150&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0t41u51024045m17%2F Abstract  The aim of this study was to determine the effects of hip circumference (HC) and height on diabetes incidence in non-diabetic first-degree relatives (FDRs) of patients with type 2 diabetes. A total of 1,092 (254 men and 838 women) non-diabetics FDRs ≥ 30 years old in 2003–2005 were followed through 2010 for the occurrence of type 2 diabetes. At baseline and through follow-ups, participants were underwent a standard 75 g 2-h oral glucose tolerance test. The incidence of type 2 diabetes was 17.0 (95% CI: 13.7, 20.2) (13.0 men and 18.1 women) per 1,000 person-year based on 6,015 person-years of follow-up. Height was inversely associated with diabetes incidence. The age-, gender-, and waist-adjusted relative risk (95% CI) of diabetes was 0.54 (0... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5409150 Fri, 11 Nov 2011 12:49:48 +0100 5409150 http://www.medworm.com/index.php?rid=5409153&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp716m5421216x632%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00592-011-0345-2Authors F. Gloria-Bottini, Division of Biopathology of Human Populations and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Via Montpellier, 00133 Rome, ItalyM. Banci, Department of Cardiology, Valmontone Hospital, 00038 Valmontone, ItalyP. Saccucci, Division of Biopathology of Human Populations and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine, University of Rome Tor Vergata, Via Montpellier, 00133 Rome, ItalyA. Neri, Division of Biopathology of Human Populations and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, School of Medicine,... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5409153 Tue, 08 Nov 2011 16:48:55 +0100 5409153 http://www.medworm.com/index.php?rid=5409152&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg5382v61023h1468%2F Abstract  Diabetic retinopathy is the leading cause of blindness in adults, and oxidative stress has been pathogenically associated with retinal neurodegeneration. Cellular stresses induce expression of heat shock proteins (HSPs) and this results in cytoprotection. Our aim was to assess retinal expression of HSP25 in early experimental diabetes. Mice were rendered diabetic by streptozotocin injection. Ten weeks after diabetes onset retinal HSP25 expression were studied by real-time PCR, immunoblotting and immunohistochemistry (IHC). Expression of nitrotyrosine and Cu/Zn superoxide dismutase (SOD), was assessed by IHC and apoptosis by TUNEL. Retinal HSP25 mRNA and protein expression was significantly increased in diabetic as compared to non-diabetic animals and localised pre... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5409152 Tue, 08 Nov 2011 16:48:55 +0100 5409152 http://www.medworm.com/index.php?rid=5409151&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg156774303415657%2F Abstract  The relationship between obesity and mortality in people with type 2 diabetes has not been definitely assessed. We have examined this issue in a well-characterized population-based cohort of Mediterranean diabetic people. Standardized anthropometric data from the population-based Casale Monferrato Study have been prospectively analyzed. The cohort included 1,475 people (62.6% aged ≥65 years) who had been recruited in 1991 and followed-up to December 31, 2006. Cox proportional hazards modeling was employed to estimate the independent associations between all-cause and cardiovascular mortality and BMI. Out of 1,475 people, 972 deaths occurred during a 15-year follow-up. Cox regression analyses showed that with respect to BMI <24.2 kg/m2, values of 30.0... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5409151 Tue, 08 Nov 2011 16:48:55 +0100 5409151 http://www.medworm.com/index.php?rid=5388077&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5877262h3xw25326%2F In conclusion, Ang-(1-7) can protect against oxidative stress and improve glucose metabolism in adipocytes. These results show that Ang-(1-7) is a novel target for the improvement of glucose metabolism by preventing oxidative stress. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00592-011-0348-zAuthors Chang Liu, Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730 ChinaXiao-Hong Lv, Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730 ChinaHong-Xing Li, Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730 ChinaXi Cao, Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730 ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5388077 Mon, 31 Oct 2011 17:01:54 +0100 5388077 http://www.medworm.com/index.php?rid=5388076&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd625w304803w3466%2F Abstract  Previous studies of bone turnover markers in diabetes are limited, and the results are conflicting. Our aim was to evaluate differences in bone turnover markers and i-PTH between T2DM and non-diabetes subjects. Cross-sectional study including 133 subjects (78 T2DM, 55 without diabetes). BMD were measured by dual X-ray absorptiometry. Bone turnover markers were determined in serum. Serum levels of bone resorption markers (CTX and TRAP5b) were lower in T2DM compared with non-diabetes subjects. There were no differences in bone formation markers. i-PTH serum levels were lower in T2DM: 38.35 ± 18.20 pg/ml versus 50.22 ± 18.99 pg/ml, P < 0.05. TRAP5b and CTX were positively correlated with i-PTH (CTX: r = 0.443, P&n... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5388076 Mon, 31 Oct 2011 17:01:54 +0100 5388076 http://www.medworm.com/index.php?rid=5388075&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm7n116736r88738m%2F Abstract  In experimental animal studies, tumour necrosis factor-α (TNF-α) contributed to renal hypertrophy during diabetes, and antibodies against TNF-α have led to improved histological lesions in animals with nephrotoxicity and diabetic nephropathy. We aimed to evaluate TNF-α system activity in association with renal histology in patients with type 2 diabetes. This is a prospective, cross-sectional study of 22 patients with type 2 diabetes (16 men), 13 with microalbuminuria and 9 with normoalbuminuria. Plasma-soluble TNF-α receptor 1 and 2 (sTNFR1 and sTNFR2) concentrations were used as surrogates of TNF-α system activity. Glomerular filtration rate (GFR) was analysed using I125-Iodothalamine. Albumin excretion rate (AER) and a renal biopsy were performed in all sub... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5388075 Mon, 31 Oct 2011 17:01:54 +0100 5388075 http://www.medworm.com/index.php?rid=5388078&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcg271v01605v4568%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00592-011-0350-5Authors Kazutaka Aoki, Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 JapanHiroshi Kamiyama, Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 JapanKouichiro Yoshimura, Department of Endocrinology and Metabolism, Yokosuka Kyousai Hospital, Yokosuka, JapanMakoto Shibuya, Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 JapanKiyomi Masuda, Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City U... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5388078 Mon, 31 Oct 2011 17:01:52 +0100 5388078 http://www.medworm.com/index.php?rid=5348399&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx88j23v4r5j04573%2F Content Type Journal ArticleCategory AnnouncementPages 1-1DOI 10.1007/s00592-011-0342-5Authors Gaetano Crepaldi, The G.B. Morgagni Prizes, C.N.R. Istituto di Neuroscienze, Sezione Invecchiamento, Via Giustiniani 2, 35128 Padova, Italy Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5348399 Fri, 21 Oct 2011 06:11:53 +0100 5348399 http://www.medworm.com/index.php?rid=5348398&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff1k5v65558638733%2F Abstract  Insulin-like growth factor 2 mRNA-binding protein 2 (IFG2BP2) belongs to an mRNA-binding protein family involved in the development and stimulation of insulin action, which has attracted considerable attention as a candidate gene for type 2 diabetes (T2D) since it was first identified through genome-wide association approach. The relationship between IFG2BP2 and T2D has been reported in various ethnic groups; however, these studies have yielded contradictory results. To investigate this inconsistency, we performed a meta-analysis of 35 studies involving a total of 175,965 subjects for two wildly studied polymorphisms (rs4402960 and rs1470579) of the IFG2BP2 to evaluate the effect of IFG2BP2 on genetic susceptibility for T2D. An overall random-effects per-allele OR o... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5348398 Fri, 21 Oct 2011 06:11:53 +0100 5348398 http://www.medworm.com/index.php?rid=5336737&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F720g3r1341325827%2F Abstract  In patients with diabetes, disease per se, co-morbidities and drugs, including novel agents acting on the incretin system, have all been associated with pancreatitis with controversial data. We investigated the publicly available FDA Adverse Event Reporting System (FDA_AERS) database to gain insight into the possible association between antidiabetic agents and pancreatitis. To this aim, a case/non-case method was retrospectively performed on the FDA_AERS database (2004–2009 period). Cases were defined as reports of pancreatitis according to the Medical Dictionary for Regulatory Activities (MedDRA) terminology. All other reports associated with antidiabetics were considered non-cases. The Reporting Odds Ratio (RORs), with corresponding 95% confidential interval (... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5336737 Wed, 19 Oct 2011 05:56:03 +0100 5336737 http://www.medworm.com/index.php?rid=5336739&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F66454g08h77g43w8%2F Abstract  Continuous subcutaneous insulin infusion (CSII) is effective and safe in children and adults with type 1 diabetes. Notwithstanding, some patients decide to discontinue using CSII. We evaluated the discontinuation rate, and its related factors, in a large group of children and adolescents with type 1 diabetes using CSII in Italy. Data on all patients with type 1 diabetes younger than 18 years were collected by 28 Pediatric Diabetologic referral Centers located throughout Italy. The primary endpoint was to measure the discontinuation rate using CSII. Among the study population (n = 6,644), 985 (14.8%) were using CSII. Sixty patients discontinued using CSII, representing the 6.1%. The discontinuation rate significantly increased (P = 0.002) wi... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5336739 Wed, 19 Oct 2011 05:56:02 +0100 5336739 http://www.medworm.com/index.php?rid=5336738&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx72450n47hq51711%2F Abstract  Due to the lack of appropriately designed randomized trials, the definitive answer in regard to the prognostic role of in-hospital glucose values in patients with AMI is lacking. We prospectively assessed the prognostic role of in-hospital peak glycemia (≤1.40, 141–180 and >180 g/l) in 611 consecutive STEMI patients (diabetic and without previously known diabetes) submitted to percutaneous coronary intervention. One hundred and fifteen (18.8%) were diabetic and the remaining 496 (81.2%) without previously known diabetes. At multivariable logistic regression analysis, peak glycemia was an independent predictor for in-ICCU death in the overall population and in patients without previously known diabetes. At follow-up, in the overall population (as well a... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5336738 Wed, 19 Oct 2011 05:56:02 +0100 5336738 http://www.medworm.com/index.php?rid=5324414&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9gg5j7u4166q2322%2F In conclusion, in subjects with impaired glucose regulation, HDL-C levels are associated with indices of beta-cell dysfunction; thus, more attention, it should be deserve to HDL-C concentrations in IFG/IGT patients due their potential conversion to DM2. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s00592-011-0339-0Authors Gianluca Bardini, Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50134 Florence, ItalyIlaria Dicembrini, Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50134 Florence, ItalyCarlo Maria Rotella, Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50134... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5324414 Thu, 13 Oct 2011 15:48:34 +0100 5324414 http://www.medworm.com/index.php?rid=5324415&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg66747h897643718%2F Abstract  Inflammatory markers are elevated in type 2 diabetic patients (DP) and may predict the development of type 2 diabetes. Our aims were to analyze differences in the expression of inflammatory and immunological molecules between DP and healthy subjects and to investigate whether glycemic control might prevent the overexpression of inflammatory markers in DP. Twenty-two DP with advanced atherosclerosis and eight healthy blood donors were included. DP were classified as well (HbA1c ≤ 6.5) or poorly controlled (HbA1c > 6.5). In “in vitro” studies, monocytes were exposed to low (5.5 mM) or high glucose (26 mM) concentrations in the absence or presence of insulin. Expression profiling of 14 inflammatory genes was analyzed using TLDA an... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5324415 Thu, 13 Oct 2011 15:48:33 +0100 5324415 http://www.medworm.com/index.php?rid=5315185&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F07t13t7m6831n455%2F Abstract  Published data on the role of neonatal jaundice as a risk factor for childhood type 1 diabetes mellitus is inconsistent. We aimed to review systematically, the evidence for an increased risk of type 1 diabetes in children diagnosed with neonatal jaundice. A comprehensive search of the published literature was performed to identify studies that had recorded the occurrence of neonatal jaundice in a group of children with type 1 diabetes and in a group of control children. Odds ratios (ORs) were extracted from reports or derived from tabulated data and then combined using a random effects meta-analysis. Data were available from 12 case–control studies and one retrospective cohort study. Overall, there was only weak evidence of an increase in the risk of type 1 diab... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5315185 Sat, 08 Oct 2011 15:44:23 +0100 5315185 http://www.medworm.com/index.php?rid=5315184&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8226185295615157%2F Abstract  In the setting of acute myocardial infarction, hyperglycemia and acute insulin resistance may represent a stress response to myocardial injury mainly related to acute catecholamine release. By measuring glucose values and insulin resistance (Homeostatic Model Assessment index—HOMA), we evaluated in 356 non-diabetic patients with ST-elevation myocardial infarction (STEMI) undergone mechanical revascularization: (a) the acute glycometabolic response by evaluating insulin resistance, glucose levels, and their combination and (b) whether insulin resistance and increased glucose values (and their combination) are able to affect in-Intensive Cardiac Care Unit (ICCU) mortality and complications. In the overall population, 226 (63.5%) patients showed glucose values ≤1... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5315184 Sat, 08 Oct 2011 15:44:23 +0100 5315184 http://www.medworm.com/index.php?rid=5304985&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbw4058v72l132n6p%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00592-011-0335-4Authors Dong-Mei Meng, Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA, USALuan Wang, Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA, USAJian-Rui Xu, Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA, USASheng-Li Yan, Department of Internal Medicine, The Affiliated Hospital of Qingdao University Medical College, Qingdao, People’s Republic of ChinaLi Zhou, Henry Ford Hospital Immunology Program, Department of Dermatology and Internal Medicine, Henry Ford Health System, 1 Ford Place, Detroit, MI, USAQing-Sheng Mi, Henry Ford Hospital Immunology Program, Department of Dermatology... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5304985 Fri, 07 Oct 2011 16:00:46 +0100 5304985 http://www.medworm.com/index.php?rid=5304986&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F32n77v5764622826%2F Abstract  The purpose of this study is to assess the immediate effects of insulin-induced hypoglycemia on the natural antioxidant superoxide dismutase activity, malondialdehyde concentration, total antioxidative capacity and total thiol group concentration in young healthy subjects. In this clinical trial, 16 healthy men with the mean age of 29.3 ± 5.3 years (range 21–39 years) became volunteers to participate the study. Hypoglycemia was induced by intravenous administration of regular insulin 0.1 U/kg. Before and after inducing hypoglycemia, SOD activity was determined in red blood cells, whereas the MDA concentration was determined by thiobarbituric acid reactive substance method, total thiol groups by high-performance liquid chromatography meth... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5304986 Fri, 07 Oct 2011 16:00:45 +0100 5304986 http://www.medworm.com/index.php?rid=5297451&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn126335m2u27k1q4%2F Abstract  To examine longitudinally the effect of diabetes on bone structure and metabolism, we measured bone mineral density (BMD) and turnover markers in 26 type 1 (mean age 49 years) and 27 type 2 (mean age 65 years) diabetic patients without known osteoporosis from a community-based sample at baseline and 5 years later. In the 17 type 1 men, BMD fell at the femoral neck (0.804 ± 0.145 vs. 0.769 ± 0.129 g/cm2; P = 0.003) with no change at lumbar spine or forearm. In the 11 type 2 women, BMD decreased at all sites except spine (femoral neck 0.779 ± 0.119 vs. 0.742 ± 0.090 g/cm2; P = 0.019). BMD did not fall at any site in type 1 women or type 2 men. There was an increase in serum alkali... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5297451 Wed, 05 Oct 2011 05:50:07 +0100 5297451 http://www.medworm.com/index.php?rid=5286282&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F90427037g12021p5%2F Abstract  More than several hundreds of millions of people will be diabetic and obese over the next decades in front of which the actual therapeutic approaches aim at treating the consequences rather than causes of the impaired metabolism. This strategy is not efficient and new paradigms should be found. The wide analysis of the genome cannot predict or explain more than 10–20% of the disease, whereas changes in feeding and social behavior have certainly a major impact. However, the molecular mechanisms linking environmental factors and genetic susceptibility were so far not envisioned until the recent discovery of a hidden source of genomic diversity, i.e., the metagenome. More than 3 million genes from several hundreds of species constitute our intestinal microbiom... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5286282 Sun, 02 Oct 2011 05:46:26 +0100 5286282 http://www.medworm.com/index.php?rid=5286281&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh12561x6v245844g%2F Abstract  To evaluate HbA1c as a diagnostic tool in prediabetes—impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and newly detected diabetes (NDD), defined by plasma glucose and OGTT. 2,231 subjects, of mean age 50.3 ± 13.9 years and mean BMI 29.5 ± 6.2 kg/m2, underwent an OGTT. HbA1c performance was assessed using the area under the receiver operating characteristics curve (AUC-ROC). HbA1c was significantly higher in all groups with altered glucose tolerance—5.72 ± 0.61% in IFG, 5.84 ± 0.63% in IGT, and 7.5 ± 1.69% in NDD when compared to normal glucose tolerance—5.23 ± 0.65% (P < 0.0001). HbA1c of both prediabetic groups was significantly lower in comparison wi... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5286281 Sun, 02 Oct 2011 05:46:26 +0100 5286281 http://www.medworm.com/index.php?rid=5286283&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa311g8816nu7483k%2F In conclusion, CSII treatment may improve glycemic control and reduce its variability. Change of MDI to CSII does not alter the risk of hospitalization and may reduce the annual duration of hospitalization in children with diabetes. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00592-011-0332-7Authors Wojciech Fendler, Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, 36/50 Sporna St., 91-738 Lodz, PolandAnna Iza Baranowska, Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, 36/50 Sporna St., 91-738 Lodz, PolandBeata Mianowska, Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, 36/50 Sporna St., 91-738 Lodz, PolandAgnieszka ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5286283 Sat, 01 Oct 2011 06:44:44 +0100 5286283 http://www.medworm.com/index.php?rid=5274540&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk5943664834qp031%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-1DOI 10.1007/s00592-011-0327-4Authors Antonio Picarelli, Department of Internal Medicine and Medical Specialities, Center for Research and Study of Celiac Disease, Sapienza University, Rome, ItalyMarco Di Tola, Department of Internal Medicine and Medical Specialities, Center for Research and Study of Celiac Disease, Sapienza University, Rome, ItalyTania D’Amico, Endocrinologia ‘‘A’’, Department of Experimental Medicine, Sapienza University, Rome, ItalyValeria Mercuri, Endocrinologia ‘‘A’’, Department of Experimental Medicine, Sapienza University, Rome, ItalyPatrizia Gargiulo, Endocrinologia ‘‘A’’, Department of Experimental Medicine, Sapienza University, Rome, Italy Journal Acta Diabetolog... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5274540 Wed, 28 Sep 2011 05:52:01 +0100 5274540 http://www.medworm.com/index.php?rid=5274541&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa8t2150541642p19%2F Abstract  Until early 2000, permanent and transient neonatal diabetes mellitus (NDM), defined as diabetes with onset within 6 weeks from birth that requires insulin therapy for at least 2 weeks, were considered exceedingly rare conditions, with a global incidence of 1:500,000–1:400,000 live births. The new definition of NDM recently adopted, that includes patients with diabetes onset within 6 months of age, has prompted studies that have set the incidence of the permanent form alone between 1:210,000 and 1:260,000 live births. Aim of the present work was to ascertain the incidence of NDM (i.e. permanent + transient form) in Italy for years 2005–2010. Patients referred to the Italian reference laboratory for NDM between years 2005 and 2010 and sc... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5274541 Wed, 28 Sep 2011 05:52:00 +0100 5274541 http://www.medworm.com/index.php?rid=5261430&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft2x1n41424311873%2F Abstract  We determined the levels of the endogenous angiogenesis inhibitors soluble vascular endothelial growth factor receptor-1 (sVEGFR-1), thrombospondin (TSP)-1 and TSP-2 in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR) and correlated their levels with clinical disease activity and the levels of vascular endothelial growth factor (VEGF). Vitreous samples from 30 PDR and 25 nondiabetic patients were studied by enzyme-linked immunosorbent assay. TSP-1 was not detected. VEGF and TSP-2 levels were significantly higher in PDR with active neovascularization compared with inactive PDR and nondiabetic patients (P < 0.001 for both comparisons). VEGF, sVEGFR-1 and TSP-2 levels were significantly higher in PDR with hemorrhage compared ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5261430 Sat, 24 Sep 2011 15:44:37 +0100 5261430 http://www.medworm.com/index.php?rid=5261429&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3m4t69j16442485x%2F Abstract  Cardiovascular disease is the predominant cause of morbidity in people with type 2 diabetes. Hypertension frequently coexists with diabetes and substantially increases the risk of developing end-organ damage. Controlling hypertension in patients with diabetes is therefore critical to reducing microvascular and macrovascular complications. Agents that block the renin-angiotensin system are increasingly used in patients with diabetes based on their cardiovascular and renoprotective effects, in addition to their direct effects on reducing blood pressure. Telmisartan, an angiotensin II receptor blocker (ARB), has a number of distinguishing pharmacological properties such as having the longest half-life and highest lipophilicity in its class. The ONgoing Telmisartan Al... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5261429 Sat, 24 Sep 2011 15:44:37 +0100 5261429 http://www.medworm.com/index.php?rid=5251230&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5u8461011573q15w%2F Abstract  Chronic inflammation contributes to insulin resistance and type 2 diabetes mellitus (T2DM). We investigated whether treatment with salsalate, an anti-inflammatory medication, improves glycemia in a group of newly diagnosed drug-naïve patients with T2DM. The study was a randomized, double-blind, placebo-controlled trial. Diagnosis of T2DM was made within 2 months of enrollment, and participants had not received any anti-glycemic agent. Sixty adults were randomized to receive salsalate (3 g/day) or placebo for 12 weeks. Fasting plasma glucose and insulin, glucose 2 h after 75 g oral glucose, HbA1C, lipid profile, HOMA-IR, and HOMA-B were determined before and after treatment. Salsalate reduced fasting glucose from 6.3 ± 0.2 m... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5251230 Thu, 22 Sep 2011 06:37:44 +0100 5251230 http://www.medworm.com/index.php?rid=5209605&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff450034nw2611qr3%2F In this study, we compared the effectiveness of the administration of miglitol alone just before breakfast on the plasma glucose, serum insulin and glucagon, and plasma incretin levels in sitagliptin-treated patients with type 2 diabetes. We measured the plasma glucose, serum insulin and glucagon, plasma active GLP-1, and total glucose-dependent insulinotropic polypeptide levels before breakfast, at 120 min after breakfast, before lunch, and 60 and 120 min after lunch in patients with diabetes who are receiving sitagliptin. This trial was performed for the following 2 days on each subject (Day 1: no miglitol, Day 2: miglitol alone [50 mg] administered just before breakfast). The area under the curve (AUC) of the plasma glucose levels after lunch in the miglitol-tr... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5209605 Tue, 06 Sep 2011 15:48:22 +0100 5209605 http://www.medworm.com/index.php?rid=5176085&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg1g5856546j20857%2F Abstract  To evaluate whether treatment with insulin analogues is associated with a lower risk of hypoglycaemia (HYPO score) and less glycaemic variability (Lability Index) than treatment with human insulin in patients with type 1 diabetes. In a 6-month prospective, open-labelled trial, we randomized 47 patients treated with human insulin to receive treatment with human insulin (n = 21) or insulin analogues (n = 26). HYPO score, Lability Index (LI), and hypoglycaemic episode characteristics were assessed at baseline and at the end of follow-up. A 72-h, continuous glucose monitoring was performed at the end in a subgroup of patients. Groups were compared with nonparametric tests. Significance was defined as P < 0.05. HYPO score (71.5 [36.0–16... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5176085 Sat, 27 Aug 2011 05:55:42 +0100 5176085 http://www.medworm.com/index.php?rid=5162741&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe40xx8q6812542j0%2F Abstract  Predictors of long-term glycemic control and growth patterns in children diagnosed with type 1 diabetes (T1D) before 6.5 years of age were evaluated. One hundred seventy-three children (84 boys) with a mean diabetes duration of 4.9 ± 2.8 years participated in this observational study. Medical charts were reviewed for background, disease- and treatment-related parameters, and growth parameters. Study endpoints were HbA1c value, rates of severe hypoglycemia and diabetic ketoacidosis events, and growth patterns. Mean HbA1c for the total duration of diabetes (HbA1c–TDD) was 7.9 ± 0.8%. Comparison of the study variables between patients with HbA1c–TDD <7.5% (n = 53) or ≥7.5% yielded a significantly shorter duration of d... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5162741 Wed, 24 Aug 2011 16:06:04 +0100 5162741 http://www.medworm.com/index.php?rid=5162742&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw71x60u581530548%2F We examined insulin secretion impairment and insulin resistance in overweight patients with T2D who had metformin failure, with elevated HbA1c at maximal metformin dose. Patients (N = 1,039) were examined at entry to the European Exenatide (EUREXA) clinical trial of add-on exenatide versus sulphonylurea. Mean (±SD) age was 57 ± 10 years, and BMI was 32.4 ± 4.1 kg/m2. All patients underwent an oral glucose tolerance test; HOMA-IR, HOMA-B, ∆I 30/∆G 30, disposition index and pro-insulin/insulin ratio were evaluated in relation to stratified HbA1c levels (≤7.3, >7.3–8.2, >8.2%) and duration of diabetes (<3, ≥3–<6, ≥6 years) using non-parametric analysis of variance. Patients overall had a wide range of imp... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5162742 Mon, 22 Aug 2011 16:05:45 +0100 5162742 http://www.medworm.com/index.php?rid=5132636&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn80pn488h7n18276%2F In conclusion, a MUFA-rich diet and a carbohydrate/fiber-rich diet induced similar effects on plasma hs-CRP concentrations. However, these dietary approaches seem to influence hs-CRP levels through different mechanisms. i.e., direct acute postprandial effects by MUFA and triglyceride-rich lipoproteins mediated effects by CHO/fiber. Content Type Journal ArticlePages 1-4DOI 10.1007/s00592-011-0318-5Authors L. Bozzetto, Department of Clinical and Experimental Medicine, Federico II University, Via S Pansini 5, 80131 Naples, ItalyC. De Natale, Department of Clinical and Experimental Medicine, Federico II University, Via S Pansini 5, 80131 Naples, ItalyL. Di Capua, Department of Clinical and Experimental Medicine, Federico II University, Via S Pansini 5, 80131 Naples, ItalyG. Della Cort... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5132636 Thu, 11 Aug 2011 05:54:08 +0100 5132636 http://www.medworm.com/index.php?rid=5132635&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx8j466x57790j134%2F Abstract  Muscarinic acetylcholine receptor (mAChR) activation of pancreatic β-cells elevates intracellular Ca2+ and potentiates glucose-stimulated insulin secretion. In addition, it activates a number of signaling molecules, including ERK1/2, whose activation has been shown to play an important role in regulating pancreatic β-cell function and mass. The aim of this work was to determine how mAChR activation elevates intracellular Ca2+ concentration ([Ca2+] i ) and activates ERK1/2 in the pancreatic β-cell line MIN6. We demonstrate that agonist-stimulated ERK1/2 activation is dependent on the activation of phospholipase C and an elevation in [Ca2+] i , but is independent of the activation of diacylglycerol-dependent protein kinase C isoenzymes. Using a pharmacological a... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5132635 Thu, 11 Aug 2011 05:54:08 +0100 5132635 http://www.medworm.com/index.php?rid=5132637&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F62t5mm6210m71v21%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00592-011-0316-7Authors Paola Pascolo, Institute for Child Health IRCCS Burlo Garofolo, Trieste, ItalyElena Faleschini, Institute for Child Health IRCCS Burlo Garofolo, Trieste, ItalyGiorgio Tonini, Institute for Child Health IRCCS Burlo Garofolo, Trieste, ItalyAlessandro Ventura, Institute for Child Health IRCCS Burlo Garofolo, Trieste, Italy Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5132637 Thu, 11 Aug 2011 05:54:07 +0100 5132637 http://www.medworm.com/index.php?rid=5120200&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa288121566023201%2F We present four IAT recipients treated with oral or injected corticosteroids after transplant for medical conditions unrelated to chronic pancreatitis or TPIAT. Hyperglycemia or insulin resistance was evident in all four patients, including reversion to long-term insulin therapy in two patients. One patient receiving corticosteroid injections had a transient increase in hemoglobin A1c (+0.6% above baseline), and one patient given a one time dose of oral dexamethasone exhibited hyperglycemia despite high insulin (>200 mU/L) and C-peptide (15.3 ng/mL) production on an oral glucose tolerance test. IAT recipients have insufficient islet mass to compensate for the insulin resistance induced by corticosteroids. Caution should be given to using these agents in IAT recipients. W... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5120200 Sun, 07 Aug 2011 05:52:21 +0100 5120200 http://www.medworm.com/index.php?rid=5064098&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxpk6348677201720%2F In this report, we present histological evidence from human CP pancreases to support the theory that islet neogenesis can occur from ductal precursor cells after birth. Three young patients (ages 16, 12, and 28 years) underwent total pancreatectomy for the management of CP followed by islet isolation and autologous transplantation to prevent or minimize postsurgical diabetes. In all cases, the pancreases had extensive fibrosis, a rock-like consistency, and calcifications in the ducts. During islet isolations, we observed the unusual release of islets with many ductal fragments. In histopathological evaluation of these pancreases, solid cords of cells sometimes formed islet like structures intraductally or extending from ductal structures. Immunofluorescence staining for chromogr... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5064098 Tue, 19 Jul 2011 23:40:16 +0100 5064098 http://www.medworm.com/index.php?rid=5053376&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj40522523522356r%2F Abstract  We determined in non-diabetic persons the risk of fasting and non-fasting glucose levels for pre-diabetes, diabetes, and coronary heart disease (CHD), including the roles of serum C-reactive protein (CRP) and HDL cholesterol, and delineated risk profiles of the pre-diabetic states. Over 7¼ years, 2,619 middle-aged Turkish adults free of diabetes and CHD were studied prospectively. Using different serum glucose categories including impaired fasting glucose (IFG, 6.1–6.97 mmol/L) and impaired glucose tolerance (IGT), outcomes were analyzed by Cox regression. IFG was identified at baseline in 112 and IGT in 33 participants. Metabolic syndrome components distinguished individuals with IFG from those with normoglycemia. Participants with IGT tended to diffe... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5053376 Mon, 18 Jul 2011 15:53:45 +0100 5053376 http://www.medworm.com/index.php?rid=5040497&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa3m02uu788427vj3%2F Abstract  The aim of this study was to evaluate the beta cell and incretin function in patients with HNF4A and HNF1A MODY during a test meal. Clinical characteristics and biochemical data (glucose, proinsulin, insulin, C-peptide, GLP-1 and GIP) during a test meal were compared between MODY patients from eight different families. BMI-matched T2D and healthy subjects were used as two separate control groups. The early phase of insulin secretion was attenuated in HNF4A, HNF1A MODY and T2D (AUC0-30 controls: 558.2 ± 101.2, HNF4A MODY: 93.8 ± 57.0, HNF1A MODY: 170.2 ± 64.5, T2D: 211.2 ± 65.3, P < 0.01). Markedly reduced levels of proinsulin were found in HNF4A MODY compared to T2D and that tended to be so also in HNF1A MODY... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5040497 Fri, 15 Jul 2011 05:54:06 +0100 5040497 http://www.medworm.com/index.php?rid=5031056&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F92j14338682413n5%2F Abstract   To investigate the influence of atrovastatin treatment on carotid intima-media thickness (CIMT) and serum levels of novel adipokines, like apelin, visfatin (nampt), and ghrelin, in patients with type 2 diabetes mellitus (T2DM). 87 statin-free patients (50 males) with T2DM, aged 55–70, but without carotid atherosclerotic plaques were initially enrolled. CIMT was assayed in all participants by ultrasound. Patients were then treated with atorvastatin (10–80 mg) to target LDL <100 mg/dl. Anthropometric parameters, blood pressure, glycemic and lipid profile, high-sensitivity CRP (hsCRP), insulin resistance (HOMA-IR), apelin, visfatin and ghrelin were measured at baseline and after 12 months. Atorvastatin treatment significantly improved lipid... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5031056 Tue, 12 Jul 2011 05:56:42 +0100 5031056 http://www.medworm.com/index.php?rid=5021454&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh6t7563150826585%2F Abstract  A 54-year-old Italian female patient was admitted to our Department with the diagnosis of type 2 diabetes poorly controlled with insulin therapy. The patient was born by consanguineous parents (first degree cousins); she had acromegaloid features, diffuse lipoatrophy and muscular pseudo-hypertrophy since childhood. To confirm the clinical hypothesis of congenital generalized lipodystrophy (CGL) or Berardinelli-Seip syndrome, the sequences of AGPAT2 (encoding for 1-acyl-sn-glycerol-3-phosphate acyltransferase beta) and BSCL2 (encoding for seipin) candidate genes were analyzed. DNA analysis showed the presence of a homozygous mutation in exon 3 of the AGPAT2 gene (P112L). This is the first description of a Caucasian subject with CGL who carries the pathologic alleli... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=5021454 Sat, 09 Jul 2011 06:17:32 +0100 5021454 http://www.medworm.com/index.php?rid=4999686&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6683p81066038q32%2F Abstract  In late twentieth century, Ruderman and Reaven showed that insulin resistance might be fundamental to metabolic syndrome (MetS) which means a constellation of obesity-related metabolic derangements predisposing to type 2 diabetes and cardiovascular disease. In 2001, user-friendly National Cholesterol Education Program (NCEP) criteria of MetS were proposed. In 2005, the International Diabetes Federation (IDF) and the Examination Committee for Criteria of Metabolic Syndrome in Japan issued different criteria of MetS where abdominal obesity is a necessary component. In 2009, IDF, National Heart, Lung, and Blood Institute, American Heart Association, World Heart Federation, International Atherosclerosis Society, and International Association for the Study of Obesity j... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4999686 Fri, 01 Jul 2011 05:43:21 +0100 4999686 http://www.medworm.com/index.php?rid=4970908&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4374hp2u17585h2k%2F Abstract  A novel algorithm to predict incident type 2 diabetes mellitus (iT2DM) is presented considering data from a 20-year prospective study in a Southern Italy population. Eight hundred and fifty-eight out of 1,351 subjects (24–85 years range of age) were selected. Incident type 2 diabetes was diagnosed in 103 patients in a 20-year follow-up. The Finnish Diabetes Risk Score (FINDRISC) and the Framingham Offspring Study simple clinical model (FOS) have been used as reference algorithms. Two custom algorithms have been created using Cox parametric hazard models followed by PROBIT analyses: the first one (VHSRISK) includes all the study subjects and the second one (VHS95RISK) evaluates separately subjects with baseline fasting blood glucose (FBG) above/below 5.2&nbs... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4970908 Thu, 23 Jun 2011 06:03:06 +0100 4970908 http://www.medworm.com/index.php?rid=4970909&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc03q1g41q58r7174%2F Abstract  Pancreatic beta cell dysfunction and reduced insulin sensitivity are fundamental factors associated with glucotoxicity, lipotoxicity and oxidative stress in type 2 diabetic patients (T2DM). Diabetic milieu can induce apoptosis in several types of cells. The aim of present study was to compare circulating soluble apoptotic markers (sFas and sFas-L) with HOMA-IR, HOMA-%S, HOMA-%B in the serum of newly diagnosed T2DM and healthy subjects. For this study, 94 T2DM and 60 healthy subjects were enroled and evaluated for various parameters. Biochemical quantifications were performed with Syncron CX5 auto-analyzer. The levels of serum sFas-L, TNF-α and IL-6 were estimated by flowcytometry. The fasting serum insulin and sFas quantified by ELISA. HOMA-IR, HOMA-%S and HOMA-%... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4970909 Tue, 21 Jun 2011 20:55:16 +0100 4970909 http://www.medworm.com/index.php?rid=4970910&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn272t1l672167372%2F Abstract  Many reports indicate a hypercoagulative state in diabetes mellitus as result of endothelial damage. Experimental evidence suggests that a metabolic derangement triggers a cascade of biochemical events that lead to vascular dysfunction. The net effect is to convert the endothelium from thromboresistant to thrombogenic surface. In literature, a strong association between type 1 diabetes mellitus (DM1) and celiac disease (CD) has been reported. We do not have information about the hemostatic system in these associated conditions. Our study aims at evaluating whether the presence of CD in a group of DM1 patients is associated with a different expression of some hemostatic factors and with a different manifestation and/or progression of microvascular complications of ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4970910 Tue, 21 Jun 2011 16:42:50 +0100 4970910 http://www.medworm.com/index.php?rid=4961837&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F775g714g66ju5324%2F Abstract  Even though autoantibodies to pancreatic islet cells are normally found in type 1 diabetes and insulin-resistance due to overweight is more reminiscent of type 2 diabetes, some studies have described β-cell antibodies also in maturity-onset diabetes of the young (MODY) and in type 2 diabetes. A 7-year-old girl was referred to our Unit for incidental hyperglycemia and family history of MODY2 and type 2 diabetes. Genetic evaluation confirmed mutation L134P in exon 4 of the glucokinase gene and a high HLA-risk of type 1 diabetes. During follow-up, she developed type 1 diabetes and overweight-induced metabolic syndrome. The coexistence of MODY, type 1 diabetes and overweight-induced metabolic syndrome confirms that diabetes subtype probably represents a continuum of ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4961837 Mon, 20 Jun 2011 14:14:08 +0100 4961837 http://www.medworm.com/index.php?rid=4961836&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpr12x51n67812633%2F Abstract  1,5-anhydroglucitol (1,5-AG) has been suggested as a marker for short-term glycemic control and postprandial hyperglycemia. However, the role of 1,5-AG in glycemic variability has not been established. The aim of this study was to demonstrate the usefulness of 1,5-AG as a marker for glycemic variability in patients with type 2 diabetes. Sixty patients with type 2 diabetes were enrolled, and a continuous glucose monitoring system (CGMS) was applied for 72 h. Continuous overlapping net glycemic action (CONGA), mean amplitude of glycemic excursion (MAGE), and mean of the daily differences (MODD) were calculated for the assessment of glycemic variability and compared with 1,5-AG. Urinary 8-iso prostaglandin F2α (8-isoPGF2α) was measured to assess oxidative stres... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4961836 Mon, 20 Jun 2011 14:14:08 +0100 4961836 http://www.medworm.com/index.php?rid=4961839&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm04438051v266543%2F Abstract  Kidneys play an important role in retinol turnover. We postulated that retinol homeostasis is disturbed in diabetic nephropathy. The aim of this research was to study the effect of kidney impairment on urinary excretion and on serum concentrations of retinol in type 2 diabetes mellitus patients. For this purpose, 41 type 2 diabetes patients and 9 sex -and age-matched healthy subjects were enrolled. Serum and urinary retinol and retinol-binding protein (RBP) were assessed by high-pressure liquid chromatography and enzyme-linked immunosorbent assay, respectively. The study showed that 17 out of 41 diabetic patients (41.5%) and none of the controls excreted retinol in urine (P < 0.02). Retinol excretion in the urine in these patients was 1.5-fold more pre... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4961839 Mon, 20 Jun 2011 14:14:06 +0100 4961839 http://www.medworm.com/index.php?rid=4961838&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm65jq3660h5tu125%2F Abstract  We wanted to examine proliferative retinopathy as a marker of incident nephropathy in a 25-year follow-up study of a population-based cohort of Danish type 1 diabetic patients and to examine cross-sectional associations between nephropathy and retinopathy in long-term surviving patients of the same cohort. All type 1 diabetic patients from Fyn County, Denmark, were identified as of 1 July 1973. One hundred and eighty four patients were examined in 1981–1982 (baseline) and in 2007–2008 (follow-up). The level of retinopathy was graded by ophthalmoscopy at baseline and nine-field digital colour fundus photographs at follow-up. Single spot urine was used to evaluate nephropathy at both examinations. Proliferative retinopathy was present in 29 patients (15.8%) at b... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4961838 Mon, 20 Jun 2011 14:14:06 +0100 4961838 http://www.medworm.com/index.php?rid=4904529&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0l82172741qw888v%2F Abstract  The aim of this study is to determine safe fasting plasma glucose (FPG) levels. We included data on 5,960 individuals aged ≥20 years at baseline with at least one follow-up examination. Diabetes was ascertained in accordance with American Diabetes Association criteria, using standard 2-h post-challenge plasma glucose test. Multivariate restricted cubic splines Weibull regression was implemented for interval-censored survival data on incident diabetes. We used Harrell’s C statistic for discrimination, Nam-D’Agostino χ2 for calibration, and Royston’s R 2 for variations in the outcome explained by models. During a 6-year median follow-up, 369 incident cases of diabetes were ascertained. Family history of diabetes, systolic blood pressure, waist-to-height... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4904529 Thu, 26 May 2011 16:07:50 +0100 4904529 http://www.medworm.com/index.php?rid=4904530&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F266qx01056gqu815%2F In this study, we assessed the association of several SNPs of CDKAL1 with T2D in 772 Russian affected patients and 773 normoglycemic controls using a Taqman-based allelic discrimination assay. We showed association of the minor allele C of rs10946398 (Odds Ratio (OR) = 1.21, 95% CI = 1.04–1.4, P = 0.016), allele C of rs7754840 (OR = 1.18, 95% CI = 1.01–1.37, P = 0.038), and allele G of rs7756992 (OR = 1.21, 95% CI = 1.04–1.42, P = 0.017) with higher diabetes risk thereby replicating the predisposing role of CDKAL1 in etiology of T2D. These alleles contribute to three haplotypes (CCA, CGG, and CCG) related to higher diabetes risk (OR = 1.48, 2.12, and 1.95). Combinations of these ha... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4904530 Tue, 24 May 2011 15:46:41 +0100 4904530 http://www.medworm.com/index.php?rid=4904531&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F870417h6121646n4%2F In this study, we assessed the relative GLUT4 level in human subcutaneous adipose tissue from obese, diabetic, and diabetic obese versus control subjects, using a real-time PCR method. GLUT4 mRNA levels were considerably decreased among type 2 diabetic patients compared with those of the controls (P < 0.01), whereas no such difference was found between obese and normal-weight controls. Multiple linear regressions analysis in both diabetic non-obese and diabetic obese groups showed a negative correlation between GLUT4 mRNA expression and both markers of obesity or insulin resistance (P < 0.01). However, in obese group, GLUT4 was inversely associated only with HOMA-IR (P < 0.01). Our findings showed that adipose GLUT4 gene expression changes were m... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4904531 Sat, 21 May 2011 23:07:18 +0100 4904531 http://www.medworm.com/index.php?rid=4854686&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4846618217v7t407%2F Abstract  The association between diabetes and subclinical atherosclerosis is well established. The effect of non-diabetic glucose intolerance on early atherosclerosis is not as straightforward, and the data regarding sex-related differences in this matter are limited. Therefore, our aim was to investigate these associations in men and women separately. We studied 1,304 Finnish men and women over 45 years of age who participated in the Finnish Health 2000 Survey. Ultrasonically determined carotid artery intima-media thickness and elasticity were used as markers of early atherosclerosis. Glucose tolerance was categorized according to the American Diabetes Association criteria for diabetes mellitus. Age-adjusted means for carotid artery intima-media thickness and elastic... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4854686 Fri, 20 May 2011 16:04:48 +0100 4854686 http://www.medworm.com/index.php?rid=4854687&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb720j94660003540%2F This study aimed at evaluating whether there is association between both EV infection and insulin resistance with islet autoantibodies in first-degree relatives of persons with type 1 diabetes. We collected sera from 94 first-degree relatives with (32) or without (64) islet cell antibodies (ICA) from the Cuban T1D prediction program. Blood glucose and insulin concentrations were determined. Antibodies to GAD65 and IA-2 were determined by radioimmunoassay. Insulin resistance was estimated by the homeostasis model assessment (HOMA-IR). EV-RNA was detected in serum using a highly sensitive reverse transcriptase-polymerase chain reaction method. The occurrence of EV-RNA was higher in ICA-positive relatives than in ICA-negative ones [15.6% (5/32) vs. 1.6% (1/62), P = 0.016]. GAD... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4854687 Fri, 20 May 2011 16:04:47 +0100 4854687 http://www.medworm.com/index.php?rid=4832289&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3452p0j2368g37v1%2F In conclusion, the presence of MS appears to modify the response to incretin-based therapies. Given the non-randomized nature of this study, these data need to be replicated. Content Type Journal ArticlePages 1-7DOI 10.1007/s00592-011-0296-7Authors Gian Paolo Fadini, Department of Clinical and Experimental Medicine, Chair and Division of Metabolic Diseases, University of Padova, Medical School, Via Giustiniani, 2., 35100 Padova, ItalySaula Vigili de Kreutzenberg, Department of Clinical and Experimental Medicine, Chair and Division of Metabolic Diseases, University of Padova, Medical School, Via Giustiniani, 2., 35100 Padova, ItalyRomelda Gjini, Department of Clinical and Experimental Medicine, Chair and Division of Metabolic Diseases, University of Padova, Medical School, Via Giust... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4832289 Sat, 14 May 2011 16:03:47 +0100 4832289 http://www.medworm.com/index.php?rid=4832288&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb114040311206722%2F Abstract  Hyperglycaemia is well known to cause reductions in plasma Na+ levels or even hyponatraemia due to an osmotically induced dilution of the interstitium and blood. It is, however, unclear whether this dilution is significantly counteracted by ion regulatory homeostatic mechanism(s) or not. Furthermore, the effects of moderate hyperglycaemia on other major ions are less well known. To further clarify these questions, we measured the changes in blood osmolarity and concentrations of Na+, K+, Cl−, Mg2+ and Ca2+ during a 4-h-long experimental hyperglycaemia in healthy subjects rendered temporarily insulin deficient using the hyperglycaemic clamp. Hyperglycaemia, 16.8 mM, was rapidly imposed from a baseline of 4.4 mM by intravenous somatostatin and glucose infu... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4832288 Sat, 14 May 2011 16:03:47 +0100 4832288 http://www.medworm.com/index.php?rid=4832290&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fat33531842540887%2F In conclusion, the prevalence of HBV and HCV is non-negligible in patients with T2DM, but these cases may long remain undiagnosed. Elevated liver enzymes might be frequently disregarded in diabetes Units and ascribed to metabolic syndrome, thus excluding T2DM patients from specific disease-modifying antiviral treatment for hepatitis. Content Type Journal ArticlePages 1-7DOI 10.1007/s00592-011-0293-xAuthors Valentina Soverini, Unit of Metabolic Diseases and Clinical Dietetics, “Alma Mater Studiorum” University of Bologna, Policlinico S. Orsola, Via Massarenti, 9, 40138 Bologna, ItalyMarcello Persico, Division of Internal Medicine and Hepatology, II° University of Naples, Naples, ItalyElisabetta Bugianesi, Division of Gastroenterology and Hepatology, University of Turin, Turin,... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4832290 Sat, 14 May 2011 16:03:46 +0100 4832290 http://www.medworm.com/index.php?rid=4822498&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl547n46k24302572%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s00592-011-0294-9Authors Rennan Feng, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150086 People’s Republic of ChinaYing Li, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150086 People’s Republic of ChinaChanghao Sun, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150086 People’s Republic of China Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4822498 Wed, 11 May 2011 06:27:14 +0100 4822498 http://www.medworm.com/index.php?rid=4806627&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F653l852p21488x35%2F In this study, we quantitated the insulin secretion rate from deconvolution analysis of the plasma C-peptide concentration during an oral glucose tolerance test (OGTT) and compared the results in IFG subjects with those in subjects with impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). One hundred and one NGT subjects, 64 subjects with isolated IGT, 24 subjects with isolated IFG, and 48 subjects with combined (IFG + IGT) glucose intolerance (CGI) received an OGTT. Plasma glucose, insulin, and C-peptide concentrations were measured before and every 15 min after glucose ingestion. Insulin secretion rate (ISR) was determined by deconvolution of plasma C-peptide concentration. Inverse of the Matsuda index of whole body insulin sensitivity was used as a m... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4806627 Sat, 07 May 2011 15:44:07 +0100 4806627 http://www.medworm.com/index.php?rid=4806628&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8141763714u0q09m%2F In conclusion, in everyday clinical practice, elderly subjects were treated with the simplest regimen and achieved the same level of metabolic control as young diabetic patients. Content Type Journal ArticlePages 1-5DOI 10.1007/s00592-011-0289-6Authors Carles Zafon, Department of Endocrinology, Hospital General Universitari Vall d’Hebron, Pg. Vall d’Hebron 119–129, 08035 Barcelona, SpainCarmen Creus, Department of Endocrinology, Hospital General Universitari Vall d’Hebron, Pg. Vall d’Hebron 119–129, 08035 Barcelona, Spain Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4806628 Thu, 05 May 2011 15:44:15 +0100 4806628 http://www.medworm.com/index.php?rid=4790587&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3733p867762j65k2%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00592-011-0290-0Authors S. Giannini, Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50134 Florence, ItalyG. Bardini, Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50134 Florence, ItalyE. Mannucci, Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50134 Florence, ItalyC. M. Rotella, Section of Endocrinology, Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50134 Florence, Italy Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4790587 Wed, 04 May 2011 14:53:30 +0100 4790587 http://www.medworm.com/index.php?rid=4790588&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc021111452268252%2F Abstract  Endothelial cell (EC) survival is critical in the maintenance of endothelial function as well as in the regulation of angiogenesis and vessel integrity since endothelial dysfunction is the initial lesion of atherosclerosis. The goal of this study was to examine the effect of diazoxide, a mitochondrial ATP-sensitive K+(mito KATP) channel opener, on aorta ECs apoptosis and its potential mechanism in Otsuka Long-Evans Tokushima Fatty (OLETF) rats at prediabetic stage. Diazoxide (25 mg kg−1 day−1) was administered intraperitoneally from age 8 weeks to age 30 weeks. Thoracic aorta and cultured thoracic aortic ECs were used. The thickening of thoracic aortic wall and apoptosis of ECs were markedly increased in OLETF rats early from the age of... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4790588 Tue, 03 May 2011 05:43:34 +0100 4790588 http://www.medworm.com/index.php?rid=4790589&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk4r124845v0g5626%2F Abstract  Previous studies have suggested an influence of vitamin D receptor alleles on bone metabolism and on susceptibility to type 1 diabetes mellitus in different ethnic populations. We aimed to investigate the distribution of vitamin D receptor (VDR) alleles in relation to biochemical bone turnover parameters and bone densitometry measurements in a group of Turkish type 1 diabetic patients. One hundred and seventeen patients (M/F 57/60, 27.6 ± 7.3 y duration of diabetes 8.1 ± 6.3 y) and 134 healthy controls (M/F 61/73, 26.2 ± 5.3 y) were included in the study. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry (DEXA). The vitamin D receptor gene (VDR) polymorphisms FokI, Bsm1, Apa1, and Taq1 were ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4790589 Tue, 03 May 2011 05:43:31 +0100 4790589 http://www.medworm.com/index.php?rid=4783152&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F956517m316pk411k%2F Abstract  This longitudinal study addressed the sequential events and metabolic consequences of lipid partitioning following uninephrectomy. Adult male Sprague–Dawley rats were randomized into sham operation (n = 15) or left uninephrectomy (UNX, n = 18). At 1 and 3 months post nephrectomy, three rats from each group were killed for histopathological examination of adipocyte differentiation and lipid accumulation. Renal protein expression of the lipogenic peroxisome proliferator-activated receptor-γ (PPAR-γ), HMG-CoA reductase (HMGCR), and adiponectin receptor was detected by Western blot and immunofluorescence microscopy. Blood lipids, glucose, insulin, and renal functions were longitudinally measured up to 10 months after operation. The UNX ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4783152 Fri, 29 Apr 2011 05:43:09 +0100 4783152 http://www.medworm.com/index.php?rid=4783153&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1226j65382243136%2F The objective of this study was to investigate the relationship of the ultrasonic CCA diameter with atherosclerotic measures and diabetic retinopathy as a microvascular complication in patients with type 2 diabetes mellitus (T2DM). This hospital-based cross-sectional study included 102 patients with T2DM (men: 65%, mean age: 57 years) who had no apparent carotid arterial stenosis and no history of cardiovascular or severe renal disease. The current smoking status, body mass index, blood pressure, hemoglobin A1c, serum low-density lipoprotein cholesterol, and ultrasonic measures of carotid arteries (CCA diameter, intima-media thickness (IMT), plaque score) were measured. The cardio-ankle vascular index (CAVI) and the presence of diabetic retinopathy were also assessed. The CCA di... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4783153 Fri, 29 Apr 2011 05:43:08 +0100 4783153 http://www.medworm.com/index.php?rid=4745281&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffw37164157571512%2F This study indicates that Valsalva, 30:15 ratio and handgrip, but not E/I ratio and Orto BP, have an independent predictive value with regard to long-term all-cause mortality. Baseline function tests hold prognostic information after at least 5 years. Content Type Journal ArticlePages 1-6DOI 10.1007/s00592-011-0283-zAuthors Ole May, Department of Medicine, Region Hospital Herning, 7400 Herning, DenmarkHanne Arildsen, Department of Infectious Diseases, Aarhus University Hospital Skejby, 8200 Aarhus N, Denmark Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4745281 Sat, 16 Apr 2011 15:57:38 +0100 4745281 http://www.medworm.com/index.php?rid=4745282&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxv8k344343x55236%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00592-011-0282-0Authors Luca Mascitelli, Comando Brigata Alpina “Julia”, 8 Via S. Agostino, 33100 Udine, ItalyMark R. Goldstein, FACP Fountain Medical Court, Bonita Springs, FL 34135, USA Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4745282 Sat, 16 Apr 2011 15:57:36 +0100 4745282 http://www.medworm.com/index.php?rid=4671982&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F933p927300146150%2F Abstract  The K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to insulin resistance, type 2 diabetes, and obesity, and conflicting results were observed in various populations. The purpose of the present study was to investigate the prevalence of K121Q polymorphism of ENPP1 gene and to clarify whether this polymorphism is associated with type 2 diabetes susceptibility in northern Chinese population. We studied the association of the ENPP1 K121Q polymorphism with type 2 diabetes (T2D) in 639 unrelated patients and 885 control subjects with normal glucose tolerance of northern China. The patients were diagnosed in accordance with the guidelines of the American Diabetes Association (ADA). Genotypes wer... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4671982 Wed, 30 Mar 2011 23:56:35 +0100 4671982 http://www.medworm.com/index.php?rid=4654621&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj688301206432975%2F The objective of this study was to prospectively evaluate the impact of diabetes on HRQOL at baseline and 6-months following ACS treated by PCI and to determine which predictors: demographic, clinical, and other variables influence QOL results in physical component summary (PCS) and mental component summary (MCS) of SF-36 health survey. The 120 consecutive patients (mean age 62.5, SD ± 9.8) with acute coronary syndrome ACS including non-ST-elevation myocardial infarction NSTEMI, n = 60 and ST-elevation myocardial infarction STEMI, n = 60 were entered into the study. Each patient was prospectively interviewed at baseline (at discharge) and 6-months following ACS. We relied on previously validated questionnaire to assess the patient’s overall health perce... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4654621 Sun, 27 Mar 2011 05:45:09 +0100 4654621 http://www.medworm.com/index.php?rid=4654620&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F328w614h118r2p40%2F Abstract  To evaluate the prevalence of depression in outpatients with type 2 diabetes and its possible correlation with anxiety, cognitive function, and clinical variables. The Zung Self-Rating Depression and Anxiety Scales and the Mini-Mental-State Examination were administered to 249 non-insulin-treated (NIT) and 249 insulin-treated (IT) outpatients with type 2 diabetes, aged 40–80, in a cross-sectional survey. Compared with a reported prevalence of 6–13% in the general population, 104 (20.9%) patients had either a score indicative of depression or were on anti-depressant medication. Assuming that medication might modify the responses to questionnaires, the latter patients were excluded from further analysis. IT patients had higher age, known duration of diabetes, Hb... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4654620 Sun, 27 Mar 2011 05:45:09 +0100 4654620 http://www.medworm.com/index.php?rid=4645043&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff400653g252j2184%2F Abstract  An increased oxidative stress and a decreased life span of erythrocytes (RBCs) are reported in patients with diabetes. Aim of this study was to assess in RBCs from patients with type 2 diabetes whether downstream effector mechanisms of apoptosis, such as activation of caspase-3, is operative, and whether an iron-related oxidative imbalance, occurring inside RBCs and in plasma, could be involved in caspase-3 activation. In 26 patients with type 2 diabetes and in 12 healthy subjects, oxidative stress was evaluated by means of different markers; non-protein-bound iron, methemoglobin and glutathione were determined in RBCs, and non-protein-bound iron was also determined in plasma. Erythrocyte caspase-3 activation was evaluated by an immunosorbent enzyme assay. Arteria... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4645043 Fri, 25 Mar 2011 05:58:40 +0100 4645043 http://www.medworm.com/index.php?rid=4645044&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx73n3262w7253u19%2F Abstract  Monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY) is usually characterized by a mild clinical phenotype. The clinical course of diabetes may be, however, highly variable. The authors present a child with diabetes manifesting with ketoacidosis during the neonatal period, born in a large family with ten members bearing a heterozygous p.Gly223Ser mutation in GCK. DNA sequencing and multiplex ligation-dependent probe amplification were used to confirm GCK mutation and exclude other de novo mutations in other known genes associated with monogenic diabetes. Continuous glucose monitoring (CGM) was used to assess daily glycemic profiles. At the onset of diabetes the child had hyperglycemia 765 mg/dl with pH 7.09. Her glycated hemoglobin level w... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4645044 Fri, 25 Mar 2011 05:58:39 +0100 4645044 http://www.medworm.com/index.php?rid=4645045&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6685n7770m366482%2F Abstract  Endothelial dysfunction and plasma markers of inflammation are significantly increased in type 2 diabetics. Several proinflammatory cytokines, acute-phase proteins, and cell adhesion molecules, such as C-reactive protein (CRP), interleukines (IL), and tumor necrosis factor alpha (TNF-α), seem to play a role in the low-grade systemic inflammation observed in these subjects. Lifestyle changes are necessary to prevent atherosclerosis and cardiovascular events. Physical exercise is known to reduce markers of inflammation by decreasing adipocytokine production and cytokine release from skeletal muscles, endothelial cells, and immune system and also improving antioxidant status. In type 2 diabetics, aerobic and resistance training have different effects on cytokine lev... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4645045 Wed, 23 Mar 2011 16:55:57 +0100 4645045 http://www.medworm.com/index.php?rid=4632577&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2753qn28882n8965%2F Abstract  Diabetic patients have a markedly increased risk of cardiovascular disease compared with non-diabetics. Two drug groups today target insulin resistance; biguanides and thiazolidinediones. In addition, these may have other effects on cardiovascular risk factors. The aim of this study was to evaluate the effects of metformin and rosiglitazone on non-traditional cardiovascular risk factors. Forty type 2 diabetic patients were randomized into metformin and rosiglitazone groups. After receiving the optimal doses, the patients were monitored for 12 weeks. Biochemical parameters, lipid parameters, CRP, insulin, c-peptide, and HbA1c levels were analyzed. VWF, PAI-1, ICAM-1, TNF-α, IL-6, E-selectin, and fibrinogen levels were measured in order to assess coagulation s... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4632577 Tue, 22 Mar 2011 06:07:06 +0100 4632577 http://www.medworm.com/index.php?rid=4617148&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe454224173424q83%2F Abstract  Both type 1 and type 2 diabetes are considered to be associated with different degrees of progressive beta cell damage. However, few long-term studies have been made. Our aim was to study the clinical course of 20 years of diabetes disease, including diabetes progression, comorbidity, and mortality in a prospectively studied cohort of consecutively diagnosed diabetic patients. Among all 233 patients diagnosed with diabetes during 1985–1987 in Malmö, Sweden, 50 of 118 surviving patients were followed-up after 20 years. The age at diagnose was 42.3 ± 23.1 and 57.5 ± 13.6 years for antibody-positive and antibody-negative patients, respectively. HbA1c and plasma lipids were analyzed with regard to metabolic control. Islet antibod... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4617148 Thu, 17 Mar 2011 19:22:53 +0100 4617148 http://www.medworm.com/index.php?rid=4617149&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd543526512082003%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00592-011-0277-xAuthors Alper Azak, Department of Nephrology, Ankara Education and Research Hospital, Ankara, TurkeyBülent Huddam, Department of Nephrology, Ankara Education and Research Hospital, Ankara, TurkeyGülay Koçak, Department of Nephrology, Ankara Education and Research Hospital, Ankara, TurkeyLevent Ortabozkoyun, Department of Nephrology, Ankara Education and Research Hospital, Ankara, TurkeyMehmet Uzel, Department of Nephrology, Ankara Education and Research Hospital, Ankara, TurkeyMurat Duranay, Department of Nephrology, Ankara Education and Research Hospital, Ankara, Turkey Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4617149 Thu, 17 Mar 2011 19:22:51 +0100 4617149 http://www.medworm.com/index.php?rid=4578625&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh7575j47270136k7%2F Abstract  The aim of this study is to assess mortality risk and the excess of risk in patients with diabetes. Patients were 15–34 years old at diagnosis of diabetes mellitus (n = 879) in 1992 and 1993 in this national cohort from Sweden. Healthy controls were matched for gender and birth on the same day as the index cases (n = 837). The civic registration number was used to link patients and controls to the Swedish Cause of Death Registry. During follow-up, 3.3% (29/879) of patients and 1.1% (9/837; P = 0.002) of controls died. The risk for a patient with diabetes to die was almost threefold increased compared with healthy controls; hazard ratio, 2.9 (95% CI 1.4–6.2). This increased risk was significant in men; hazard ratio, 2.8 (95% CI ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4578625 Wed, 09 Mar 2011 17:06:51 +0100 4578625 http://www.medworm.com/index.php?rid=4578626&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu3qq06356g78r18t%2F We report here on a patient who had type B insulin resistance syndrome with insulin and insulin receptor antibodies and this all manifested as diabetic ketoacidosis. Content Type Journal ArticlePages 1-2DOI 10.1007/s00592-011-0271-3Authors Kyong Hye Joung, Department of Internal Medicine, Chungnam National University School of Medicine, 33 Munhwa-ro, Jung-gu, Daejeon, 301721 KoreaHyun Jin Kim, Department of Internal Medicine, Chungnam National University School of Medicine, 33 Munhwa-ro, Jung-gu, Daejeon, 301721 KoreaBon Jeong Ku, Department of Internal Medicine, Chungnam National University School of Medicine, 33 Munhwa-ro, Jung-gu, Daejeon, 301721 Korea Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4578626 Wed, 09 Mar 2011 06:59:48 +0100 4578626 http://www.medworm.com/index.php?rid=4550382&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnl575h5655268065%2F Abstract  We aimed to test the effects of a psychological support program on the psychological distress, mood, and quality of life of well-educated individuals with type 1 diabetes. A newly developed support program was offered to 60 patients with type 1 diabetes on intensive insulin treatment, previously enrolled in group-care educational programs. Thirty-three subjects participated (experimental group, in groups of 8–12 subjects); 22, who postponed their entry, were used as controls. The program consisted of 7 weekly work sessions of 2 hours chaired by a psychologist and covered aspects of daily living with diabetes using role-playing, metaplan, and problem solving. At baseline and approximately 6 months later, all participants completed a battery of quest... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4550382 Wed, 02 Mar 2011 07:48:42 +0100 4550382 http://www.medworm.com/index.php?rid=4541628&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9rk197q353616xr2%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00592-011-0263-3Authors Ferdinando C. Sasso, Department of Experimental and Internal Medicine, Second University of Naples, Naples, ItalyFulvio Furbatto, Department of Cardiology, University of Naples “Federico II”, Naples, ItalyOrnella Carbonara, Department of Experimental and Internal Medicine, Second University of Naples, Naples, ItalyRodolfo Nasti, Department of Experimental and Internal Medicine, Second University of Naples, Naples, ItalySilvana Morra, Department of Experimental and Internal Medicine, Second University of Naples, Naples, ItalyRoberto Torella, Department of Experimental and Internal Medicine, Second University of Naples, Naples, ItalyFederico Piscione, Department of Cardiology, University of Naples “Federico I... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4541628 Thu, 24 Feb 2011 08:00:24 +0100 4541628 http://www.medworm.com/index.php?rid=4513678&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9315t04737u85826%2F Abstract  The aim of this study was to estimate the incidence of type 2 diabetes using newly proposed hemoglobin A1C (HbA1c) and current oral glucose tolerance test (OGTT) definition in an Iranian non-diabetic population. A total of 923 non-diabetic first-degree relatives (FDRs) of patients with type 2 diabetes 30–70 years old in 2003–2005 were followed through 2009 for the occurrence of type 2 diabetes. At baseline and through follow-ups, participants underwent a standard 75 g 2-h OGTT and HbA1c measurements. Prediction of progression to type 2 diabetes by OGTT-defined or HbA1c-defined diabetes was assessed with area under the receiver operating characteristic (ROC) curves based upon measurement of fasting plasma glucose, 2-h post-load glucose values, and HbA1c... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4513678 Mon, 21 Feb 2011 17:07:13 +0100 4513678 http://www.medworm.com/index.php?rid=4513679&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv65nh552297juq1x%2F We report a case of unusually long-lasting remission of type 1 diabetes (T1D). The patient, a Caucasian man, at the age of 43 years developed a ketotic diabetes, classified as type 1 based on clinical presentation and positivity for islet autoantibodies. Shortly after diabetes onset, oral topiramate was added to preexisting valproic acid for generalized seizures and maintained thereafter. Initial intensive insulin treatment was rapidly reduced to low doses (3 Units/day) maintained for a long time and then discontinued at month 55; fasting glucose and glycosylated hemoglobin were basically normalized at 58 months. An oral glucose tolerance test performed at month 53 showed an impaired fasting glucose (6.0 mmol/l) and a value slightly above the threshold for the dia... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4513679 Sat, 19 Feb 2011 07:24:54 +0100 4513679 http://www.medworm.com/index.php?rid=4503029&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw3u808650m540366%2F This study was to investigate the role of moesin and its underlying signal transduction in retinal vascular hyper-permeability induced by AGE-modified mouse serum albumin (AGE-MSA). Female C57BL/6 mice were used to produce an AGE-treated model by intraperitoneal administration of AGE-MSA for seven consecutive days. The inner blood–retinal barrier was quantified by Evans blue leakage assay. Endothelial F-actin cytoskeleton in retinal vasculature was visualized by fluorescence probe staining. The expression and phosphorylation of moesin in retinal vessels were detected by RT–PCR and western blotting. Further studies were performed to explore the effects of Rho kinase (ROCK) and p38 MAPK pathway on the involvement of moesin in AGE-induced retinal vascular hyper-permeability respons... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4503029 Thu, 17 Feb 2011 08:22:01 +0100 4503029 http://www.medworm.com/index.php?rid=4503031&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F545323wnx776171j%2F Abstract  The relationship between late-onset gestational diabetes mellitus [GDM] and oxidative stress is not well known, and the importance of the oxidant/antioxidant equilibrium in the clinical evolution and its complications require elucidation. The aim of the study was to evaluate the relationships between maternal levels of markers of oxidative stress in women with late-onset GDM that, potentially, may have considerable clinical implications in the pathogenesis and/or the evolution of GDM. Pregnant women (n = 78; 53 with GDM, 25 controls), between the 24th and 29th week of gestation, were enrolled. Both groups were analysed for demographic data, perinatal and obstetrics outcomes together with the levels of the marker’s oxidative stress and antioxidant statu... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4503031 Thu, 17 Feb 2011 08:22:00 +0100 4503031 http://www.medworm.com/index.php?rid=4503030&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd8p637172x4537p2%2F Abstract  The peripheral neutrophils are one of the main inflammatory cells and significantly influence the damage of endothelium. Type 2 diabetes is a manifestation of an ongoing low-grade inflammation. In diabetes, impairment of neutrophil adhesion to the endothelium and migration to the site of inflammation were detected, which associated closely with adhesion molecules expressed on neutrophils and endothelial cells. To detect the expression of syndecan-1 on neutrophils in patients with type 2 diabetes mellitus, we recruited 29 patients with type 2 diabetes mellitus without any diabetic complication and 24 healthy subjects (controls). Expression of syndecan-1 was determined by flow cytometry, and potential correlations between syndecan-1 and clinical characteristics were... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4503030 Thu, 17 Feb 2011 08:22:00 +0100 4503030 http://www.medworm.com/index.php?rid=4503032&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F41355438840u6196%2F Abstract  To investigate the possible relationship of leptin to bone mineral density (BMD) in men with type 2 diabetes mellitus (T2DM), we screened 168 Belarusian men aged 45–65 years. Plasma total cholesterol (TC), high-density lipoprotein cholesterol, and triglyceride concentrations were assessed, and low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol (LDL-C) were calculated. Hemoglobin A1c, immune-reactive insulin (IRI), serum total testosterone, and sex hormone-binding globulin were also evaluated. BMD was evaluated using dual-energy X-ray absorptiometry. By univariate linear regression analysis, BMD was significantly correlated with body mass index (r = 0.23, P = 0.002) and leptin (r = 0.21, P =&nbs... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4503032 Thu, 17 Feb 2011 08:21:58 +0100 4503032 http://www.medworm.com/index.php?rid=4471148&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgx58371587607208%2F This study aims to examine the effect of pioglitazone on potential progression of autonomic damage in addition to changes in control of cardiovascular function in patients with type 2 diabetes (T2DM). Thirty patients with T2DM and 32 healthy subjects participated in the study. Sympathovagal activity, assessed by power spectral analysis (PSA) of R–R intervals variability, and blood pressure (BP) were studied during clinostatism and orthostatism in controls and patients. We have assessed blood pressure control by 24-hour monitoring of ambulatory blood pressure. Patients were treated with pioglitazone (30 mg/day) for 6 months, and then re-evaluated by PSA for heart rate variability (HRV). Reduced levels of HbA1c (P < 0.0001) and urinary albumin (P = 0.0... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4471148 Thu, 10 Feb 2011 19:56:18 +0100 4471148 http://www.medworm.com/index.php?rid=4466041&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu4g8377078lk0025%2F Abstract  Incident diabetes and the worsening of diabetes have recently been linked to hepatic steatosis. Aim of our study was to determine whether oral hypoglycemic agent failure is associated with higher transaminase levels (valid measure of liver steatosis). We selected 200 patients, attenders (3 consecutive annual evaluations) in our clinic, with type 2 diabetes among which 100 with oral hypoglycemic agents failure and 100 who were still responsive to oral therapy. Failure to therapy was defined as glycated hemoglobin >7.5% despite maximal-dose oral therapy. We analyzed patient histories and laboratory data. Compared with oral-therapy-responsive patients, those with failure had a significantly higher level mostly of alanine aminotransferase at the time of therap... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4466041 Tue, 08 Feb 2011 21:06:40 +0100 4466041 http://www.medworm.com/index.php?rid=4442888&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw47538174l101783%2F This study evaluates the impact of diabetes mellitus on left ventricular diastolic dysfunction (LVDD) and heart rate variability in a group of type 2 diabetes mellitus without signs of cardiovascular disease. The study group consisted of 58 patients, aged 61 ± 8 years, diagnosed with type 2 DM. The subjects were selected from a series of 104 consecutive diabetic patients. All the subjects were on oral therapy or on diet for DM, and ECG was normal for all the subjects. The control group consisted of 45 healthy subjects, matched for age and sex. Heart rate variability was measured using a 24-h ECG monitoring system, and standard 2D and Doppler echocardiography was performed in all the subjects. There are significant differences between groups regarding disease duration,... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4442888 Fri, 04 Feb 2011 17:35:34 +0100 4442888 http://www.medworm.com/index.php?rid=4442889&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F53143013764u235w%2F Abstract  We investigated the cytokines and mechanisms involved in the induction of insulin resistance in human skeletal muscle. Ten subjects with impaired glucose tolerance (IGT) and 10 control subjects were recruited. We performed biopsies on the vastus lateralis muscle and used immunoblotting to determine levels of inflammatory cytokines, Toll-like receptor (TLR) gene expression, and insulin signaling. We also used a human myotube culture system to examine the mechanisms underlying TLR-4 gene expression. To identify inflammatory cytokines associated with insulin resistance, we measured the levels of IL-6, TNF-α, TLR-2, and TLR-4 in skeletal muscle from non-obese patients with IGT and control subjects. Levels of IL-6, TNF-α, and TLR-4, but not TLR-2, were significantly ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4442889 Fri, 04 Feb 2011 03:34:02 +0100 4442889 http://www.medworm.com/index.php?rid=4442890&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr33325886j046281%2F This study was undertaken to assess whether the apoE isoforms in humans were associated with normal glucose tolerance and with metabolic and inflammatory risk factors of CVD. ApoE genotype was assessed in 365 individuals. Of those, 309 were studied in the postabsorptive conditions and 142 of them also underwent a 3h-OGTT; 56 additional subjects were studied by means of the insulin clamp in combination with [6,6-2H2] glucose infusion. ApoE genotype frequencies were similar to those previously reported and were not influenced by age and BMI. Fasting plasma glucose, insulin, FFA, the lipid profile, surrogate markers (HOMA-IR, OGTT-derived index) as well as the clamp-derived parameters or insulin sensitivity and insulin secretion were not different by apoE genotypes. Serum adipokines co... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4442890 Thu, 03 Feb 2011 20:56:04 +0100 4442890 http://www.medworm.com/index.php?rid=4442891&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F578x8g6035073j2r%2F Abstract  To assess the relationships between insulin resistance and low-grade inflammation in subjects with type 1 diabetes mellitus (T1DM) who do not have clinical macrovascular complications. A total of 120 subjects diagnosed with T1DM 14 years before were evaluated for the following: (1) sex, age, body mass index, waist-to-hip ratio (WHR), blood pressure, smoking, alcohol intake, insulin dose, HbA1c and lipid profile; (2) microvascular complications; (3) plasma concentrations of soluble fractions of tumour necrosis factor-α receptors type 1 and 2, interleukin-6, adiponectin, leptin and high-sensitivity C-reactive protein (hs-CRP); and (4) insulin resistance (estimation of the glucose disposal rate—eGDR). Those subjects with an eGDR below the median of the same s... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4442891 Thu, 03 Feb 2011 20:55:56 +0100 4442891 http://www.medworm.com/index.php?rid=4429963&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fel22x7705165v147%2F We report a 55-year-old woman with poorly controlled type-2 diabetes and insulin allergy. She revealed hypersensitivity reactions including urticaria and respiratory symptoms, immediately after injection. So, specific immunotherapy with other insulin preparations was done. Finally, after specific immunotherapy, we were able to treat the patient with short- and long-acting analogs successfully. Content Type Journal ArticlePages 1-5DOI 10.1007/s00592-011-0254-4Authors S. Hasani-Ranjbar, Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th Floor, Shariati Hospital, North Kargar Ave., 14114 Tehran, IranM. R. Fazlollahi, Immunology, Asthma and Allergy Research Institute (IAARI), Tehran University of Medical Sciences, Tehran, IranA. Mehri, Endocrinol... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4429963 Fri, 28 Jan 2011 20:31:57 +0100 4429963 http://www.medworm.com/index.php?rid=4401209&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh07u444025257706%2F We describe a rare case of iatrogenic diabetes mellitus during ACTH therapy in a patient with symptomatic West syndrome. The infant had cushingoid facies, hirsutism and biochemical evidence of diabetes due to excessive glucocorticoid production with hyperplasia of both adrenal glands at ultrasound examination, without mineralocorticoid excess; in addition, he presented also short-term weight gain, marked electrolyte disturbances, hypokalemic alkalosis and infections. When ACTH is used to treat patients with West syndrome, it is necessary to follow glycemic levels until to the end of therapy. Content Type Journal ArticlePages 1-3DOI 10.1007/s00592-011-0253-5Authors Valeria Calcaterra, Department of Pediatrics, University of Pavia and IRCCS Policlinico San Matteo Foundation, P.le... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4401209 Fri, 21 Jan 2011 15:12:01 +0100 4401209 http://www.medworm.com/index.php?rid=4401210&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F600075863470145h%2F The objective of this cross-sectional observational study was to explore the association of sugar-sweetened and diet beverage intake with A1c, plasma lipids, adiponectin, leptin, systolic, and diastolic blood pressure in youth with type 1 diabetes. We examined data from 1,806 youth age 10–22 years with type 1 diabetes, of which 22% were minority (10% Hispanic, 8% African Americans, 4% other races) and 48% were female. Sugar-sweetened beverage, diet beverage, and mineral water intake was assessed with a food frequency questionnaire. After adjustment for socio-demographic and clinical covariates, physical activity and total energy intake, high sugar-sweetened beverage intake (at least one serving per day vs. none), was associated with higher levels of total cholesterol, LDL chol... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4401210 Thu, 20 Jan 2011 07:08:02 +0100 4401210 http://www.medworm.com/index.php?rid=4363440&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw7018747n2672170%2F Abstract  The aim was to analyze the relationship between metabolic syndrome (MetS) and vascular risk among the aged. A prospective population-based study, with a 9-year follow-up. All subjects of the municipality of Lieto in Finland aged ≥64 in 1998–99 participated (n = 1183). Hazard ratios (HRs) for fatal or non-fatal coronary (CHD), cerebrovascular (CV), or all vascular events predicted by MetS (defined by International Diabetes Federation) were estimated. During the 9-year follow-up, a total of 348 vascular events occurred, including 208 CHD and 150 CV events. After multivariable adjustment, CHD events (1.70, 1.07–2.71, P = .026) and vascular events (1.57, 1.07–2.30, P = .021) were more common in men with MetS compared to men without ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4363440 Fri, 14 Jan 2011 16:35:34 +0100 4363440 http://www.medworm.com/index.php?rid=4356585&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6021247t05727q12%2F We examined 53 subjects: 25 lean (BMI < 25 kg × m−2) and 28 with overweight or obesity (BMI > 25 kg × m−2) with normal glucose tolerance. Hyperinsulinemic euglycemic clamp and indirect calorimetry were performed. An increase in respiratory exchange ratio in response to insulin was used as a measure of metabolic flexibility. Obese subjects had lower insulin sensitivity, adiponectin and higher sTNFR1 (all P < 0.001) and sTNFR2 (P = 0.001). Insulin sensitivity was positively related to adiponectin (r = 0.49, P < 0.001) and negatively related to sTNFR1 (r = −0.40, P = 0.004) and sTNFR2 (r = −0.52, P < 0.001). Adiponectin was related to the... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4356585 Fri, 14 Jan 2011 16:35:34 +0100 4356585 http://www.medworm.com/index.php?rid=4325147&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F977445r170207gn2%2F This study aimed at determining which GAD65 epitopes the spontaneous antibodies recognized and whether the epitope-specific GAD65Abs could be associated with the development of thyroid autoimmunity in Chinese adult-onset type 1 diabetes (T1DM) and latent autoimmune diabetes in adults (LADA). The levels of GAD65Abs and their reactivities to N-terminal (GAD65-N), middle (GAD65-M) and C-terminal (GAD65-C) regions of human GAD65 were measured by radioligand assay in 109 patients with adult-onset T1DM and 107 with LADA. TPOAb, TGAb and the genotypes of HLADQA1-DQB1 were determined. The percentage of LADA patients with GAD65-NAb was significantly higher than that of adult-onset T1DM patients (21.5% vs. 11.0%, P = 0.037), but LADA patients with GAD65-CAb less than T1DM patients (47... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4325147 Thu, 06 Jan 2011 17:53:46 +0100 4325147 http://www.medworm.com/index.php?rid=4325148&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq3t4627476v761g7%2F This study evaluated the association between serum C-peptide levels and chronic vascular complications in Korean patients with type 2 diabetes. Data for 1,410 patients with type 2 diabetes were evaluated cross-sectionally. Fasting and postprandial 2-hour serum C-peptide levels were analyzed with respect to diabetic micro- and macrovascular complications. In the group of patients with lower fasting serum C-peptide quartile, the prevalences of diabetic retinopathy and neuropathy were significantly higher (P = 0.035, P < 0.001, respectively). In the group of patients with lower delta C-peptide (postprandial − fasting C-peptide) quartile, the prevalences of diabetic retinopathy, nephropathy, and neuropathy were significantly higher (P < 0.001 for all)... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4325148 Thu, 06 Jan 2011 17:53:44 +0100 4325148 http://www.medworm.com/index.php?rid=4325149&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F81n3984xq61873hl%2F Abstract  TNF-α and hyperglycemia are important factors contributing to vascular complications in obese and diabetic patients. The present studies aimed to examine, in endothelial cells, downstream signaling mechanisms that may ultimately link TNF-α and hyperglycemia to vascular pathology. Human umbilical vein endothelial cells were cultured and incubated with 10 ng/ml TNF-α and/or 25 mmol/l glucose. The expression of early growth response gene-1 (Egr-1) and ERK1/2 protein was quantified by Western blotting, and plasminogen activator inhibitor-1 (PAI-1) levels were measured by ELISA. Both glucose and TNF-α increased Egr-1 expression, while simultaneous exposure to the two factors exerted an additive effect. Furthermore, PAI-1 was also upregulated in the presen... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4325149 Thu, 06 Jan 2011 17:53:43 +0100 4325149 http://www.medworm.com/index.php?rid=4319363&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy542050138217771%2F Abstract  Metabolic flexibility reflects the ability to switch from lipid to carbohydrate oxidation during insulin stimulation. Impaired metabolic flexibility is related to insulin resistance and type 2 diabetes, but whether metabolic flexibility is impaired in individuals with the pre-diabetic states isolated impaired fasting glycaemia (i-IFG) and isolated impaired glucose tolerance (i-IGT) is unknown. Using the gold standard euglycaemic hyperinsulinaemic clamp technique combined with indirect calorimetry, we measured peripheral insulin sensitivity, lipid and glucose oxidation, and thus metabolic flexibility in 66 individuals with normal glucose tolerance (NGT, n = 20), i-IFG (n = 18) and i-IGT (n = 28). During insulin stimulation, individuals ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4319363 Tue, 04 Jan 2011 17:52:07 +0100 4319363 http://www.medworm.com/index.php?rid=4301082&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjkq503025m457m58%2F Abstract  The aim of the study is to assess QoL depending on the choice of therapeutic regimen. From a total of 200 patients, half (n = 100) were treated with insulin (66% were females, age 52.1 ± 7.4—group A), the remaining 100 received oral treatment (74% females, age 63.3 ± 8.3—group B). For self-assessment of QoL, the WHOQOL-BREF questionnaire was used. In group A, we found a negative influence of increased level of glycemia and occurrence of coexisting diseases in the somatic domain . In the psychological domain, frequent checkups showed a positive influence while circulatory failure produced negative results. For social domain, disobeying of recommended diet was strongly negative as well as increased levels of glycemia and coexisting ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4301082 Wed, 29 Dec 2010 17:09:50 +0100 4301082 http://www.medworm.com/index.php?rid=4301083&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqp70p8l42x287228%2F In conclusion, the current meta-analysis did not observe any association between the polymorphism of RETN −420 C/G and the risk of T2DM. The study may help us further understand the genetics of T2DM. However, larger and prospective studies are warranted to confirm this finding. Content Type Journal ArticleDOI 10.1007/s00592-010-0247-8Authors Ying Wen, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, 150086 Nangang District, Harbin, ChinaPeng Lu, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, 150086 Nangang District, Harbin, ChinaLing Dai, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 157 Baojian Road, 1500... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4301083 Tue, 28 Dec 2010 15:04:03 +0100 4301083 http://www.medworm.com/index.php?rid=4254510&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq615851mh0532jm4%2F Abstract  Since most of the current studies of thiazolidinediones (TZDs) are only focused on improving glycemic control, increasing insulin sensitivity, and regulating inflammatory states in Type 2 Diabetes, it is still controversial whether TZDs have direct, protective effects on pancreatic β-cells in autoimmune diabetes. Here, we show the protective effects of TZDs on mouse pancreatic β-cell line cells (NIT-1) impaired by exposure to inflammatory cytokines (IL-1β and IFN-γ) and explore the potential mechanisms for this. The apoptosis rate and caspase-3 activity were remarkably increased, and insulin secretion response to glucose was impaired severely by exposure to IL-1β/IFN-γ for 48 h compared to control cells, whereas apoptosis rate and caspase-3 activity wer... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4254510 Thu, 09 Dec 2010 17:52:03 +0100 4254510 http://www.medworm.com/index.php?rid=4254511&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F82176xg5ht3141k2%2F Abstract  Glycated albumin (GA) is recognized as a reliable marker for short-term glycemic monitoring in diabetic patients. We investigated the clinical relevance of GA and the ratio of GA to glycated hemoglobin (A1c) in Korean type 2 diabetic patients. In this retrospective study, we compared A1c, GA, and the GA/A1c ratio and analyzed the relationship between glycemic indices and various parameters in 1,038 Korean type 2 diabetic patients. The patients were divided into two groups: a stably maintained A1c group whose A1c levels did not fluctuate by more than 0.5% for at least 6 months and an unstably maintained A1c group whose A1c levels fluctuated by more than 0.5%. Serum GA was strongly correlated with A1c in both groups. Fasting plasma glucose and postprandial gluc... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4254511 Thu, 09 Dec 2010 17:52:00 +0100 4254511 http://www.medworm.com/index.php?rid=4246614&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6008684137t568v%2F Abstract  To evaluate the association between recreational drug use and diabetic ketosis (DK) and diabetic ketoacidosis (DKA) in our area. Retrospective examination of records from a 1,450 bed urban teaching hospital in Spain. All adult admissions for DK or DKA from January 1, 2005, to December 31, 2009 in our hospital were included. Demographic, exploratory (blood pressure, heart rate, respiratory rate), and analytical data (glucose, urea, creatinine, corrected Na+, K+, pH, HCO3− and HbA1c) at admittance were recorded. In 152 patients, 253 episodes of DK or DKA occurred. Screening for drug use was performed in 40.3% of the events; 20.6% of the episodes (n = 52) were shown to be substance abuse. Cocaine, followed by cannabis and alcohol, was the most frequently in... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4246614 Tue, 07 Dec 2010 06:54:42 +0100 4246614 http://www.medworm.com/index.php?rid=4226669&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk5661427468943m8%2F Abstract  We validated the transportability of the updated diabetes prediction model from Atherosclerosis Risk in Communities (ARIC) Study, to a Middle Eastern population. We investigated 3,721 participants of the Tehran Lipid and Glucose Study (TLGS) aged ≥20 years, free of diabetes at baseline. They underwent a standard 75gr 2-h post-challenge plasma glucose test that was repeated every 3 years using the same protocol. All the models were tested with respect to discrimination and calibration. We confirm the findings of Kahn et al. (Ann Intern Med 150(11):741–751, 2009) in a middle-aged, Middle Eastern population. We obtained the same predictive discrimination for the ARIC model (C statistic: men 0.790 and women 0.829) as for the TLGS’ own model (men 0.824 an... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4226669 Tue, 30 Nov 2010 17:49:53 +0100 4226669 http://www.medworm.com/index.php?rid=4215425&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fut07357075530534%2F Abstract  To study the prevalence of Abnormal Sleep Patterns (ASPs), gender-wise, in subjects with type II diabetes mellitus and its influence on diabetic microangiopathies. A population-based cross-sectional survey was conducted among 1,414 patients having type II diabetes mellitus. Diabetic retinopathy was graded using stereoscopic digital fundus photography. Neuropathy was assessed by measuring vibration perception threshold using a sensitometer. Nephropathy was diagnosed by the presence of microalbuminuria in the first morning urine sample. ASPs were defined as either short (less than 5 h) or long (more than 9 h) duration of sleep with excessive daytime sleepiness. The Epworth Sleepiness Scale (ESS) score was assessed to note excessive daytime sleepiness; a sc... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4215425 Sat, 27 Nov 2010 07:09:31 +0100 4215425 http://www.medworm.com/index.php?rid=4203975&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa5l17v7246k47283%2F In conclusions, dBW were significantly associated with dFPG and dHDL in Japanese men without abdominal obesity. Therefore, abdominal obesity should not be considered as a necessary component of MetS in Japanese men. dBW may be more useful than dWC as a marker of changes in cardiovascular risk factors in lifestyle intervention programs. Content Type Journal ArticleDOI 10.1007/s00592-010-0238-9Authors Eiji Oda, Medical Check-up Center, Tachikawa Medical Center, Nagachou 2-2-16, Nagaoka, Niigata, 940-0053 JapanRyu Kawai, Medical Check-up Center, Tachikawa Medical Center, Nagachou 2-2-16, Nagaoka, Niigata, 940-0053 Japan Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4203975 Tue, 23 Nov 2010 06:57:39 +0100 4203975 http://www.medworm.com/index.php?rid=4203976&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr24g7jr70840744u%2F Abstract  Painful diabetic neuropathy is one of the most common forms of neuropathic pain syndromes. Tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated as a key pain mediator in the development and maintenance of neuropathic pain conditions. Recent studies showed that endogenous TNF-alpha production was also accelerated in neural tissues and spinal cord under chronic hyperglycemia. Thus, in this study, we investigated whether pharmacological inhibition of TNF-alpha by etanercept, a TNF-alpha antagonist, could block behavioral sign of diabetic neuropathic pain. Diabetes was induced by streptozotocin (STZ) (200 mg/kg, i.p.) in Balb-c mice and behavioral tests were performed between 45 and 60 days after STZ administration. ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4203976 Tue, 23 Nov 2010 06:57:38 +0100 4203976 http://www.medworm.com/index.php?rid=4180201&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn1225x74h6070175%2F Abstract  A 59-year-old Chinese male patient was admitted at diagnosis of type1 diabetes with ketoacidosis. During the normalization of blood glucose with insulin, the patient developed acute hemolysis. The factors predisposing to hemolysis were not found, except the significantly diminished activity of glucose-6-phosphate dehydrogenase (G6PD). DNA analysis did not show any coding or intronic mutation in the G6PD gene. This is the first reported case of a Chinese patient in diabetic ketoacidosis with hemolysis induced by G6PD deficiency in the absence of mutations in the G6PD gene. Content Type Journal ArticleDOI 10.1007/s00592-010-0236-yAuthors Xue-Jiang Gu, Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wenzhou Medical College, 2 Fux... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4180201 Tue, 16 Nov 2010 07:08:41 +0100 4180201 http://www.medworm.com/index.php?rid=4165058&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr8t31v350l7657g3%2F Abstract  Diabetic cardiomyopathy is an important complication of type 1 diabetes mellitus. Diastolic heart failure is an early manifestation of diabetic cardiac disease. Nt-proBNP is a valuable marker of ventricular dysfunction. The aim of this study was to determine Nt-proBNP concentrations in type 1 diabetic patients and determine their relationship with ventricular diastolic dysfunction (DD) and carotid artery intima media thickness (CIMT) measurements. Sixty-seven type 1 diabetic patients (30.2 ± 8.0 years; W/M: 24/43) without known cardiovascular disease and 48 healthy controls (30.5 ± 6.4 years; W/M: 19/29) were recruited. Nt-proBNP levels were measured. Conventional and tissue Doppler echocardiography were used to evaluate left ventric... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4165058 Fri, 12 Nov 2010 08:49:32 +0100 4165058 http://www.medworm.com/index.php?rid=4156243&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy121hj5636vq133h%2F Content Type Journal ArticleDOI 10.1007/s00592-010-0234-0Authors Vincenzo Sepe, Unit of Nephrology, Dialysis, Transplantation, Fondazione I.R.C.C.S. Policlinico «San Matteo», Viale Camillo Golgi, 19, Pavia, ItalyPasquale Esposito, Unit of Nephrology, Dialysis, Transplantation, Fondazione I.R.C.C.S. Policlinico «San Matteo», Viale Camillo Golgi, 19, Pavia, ItalyLaura Sacco, Service of Microbiology, Fondazione I.R.C.C.S. Policlinico «San Matteo», Pavia, ItalyAdalgisa Ceci, Service of Microbiology, Fondazione I.R.C.C.S. Policlinico «San Matteo», Pavia, ItalyAnna Magrassi, University of Pavia, Pavia, ItalyMaria Teresa Negri, Unit of Nephrology, Dialysis, Transplantation, Fondazione I.R.C.C.S. Policlinico «San Matteo», Viale Camillo Golgi, 19, Pavia, ItalyCarmelo Libetta, Unit of ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4156243 Tue, 09 Nov 2010 07:49:38 +0100 4156243 http://www.medworm.com/index.php?rid=4145383&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm0773p0r34263172%2F Abstract  Plant sterols lower serum cholesterol concentration. Available data have confirmed the lipid-lowering efficacy in adults, while there is a relative dearth of data in children and almost exclusively restricted to subjects with familial hypercholesterolemia (FH). Aim of the present study was to evaluate the efficacy, tolerability and safety of plant sterol supplementation in children with different forms of primary hyperlipidemias. The effect of plant sterol consumption on plasma lipids was evaluated in 32 children with heterozygous FH, 13 children with Familial Combined Hyperlipidemia (FCH) and 13 children with Undefined Hypercholesterolemia (UH) in a 12-week open-label intervention study using plant sterol–enriched yoghurt. Plasma lipids and apolipoproteins were ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4145383 Sat, 06 Nov 2010 20:18:46 +0100 4145383 http://www.medworm.com/index.php?rid=4141244&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F521g51817021513h%2F Abstract  Elevated serum uric acid (SUA) concentrations have been suggested to associate with metabolic syndrome (MetS) and its components. However, limited information is available regarding the relationship between SUA and MetS in subjects with normal glucose levels. A total of 501 subjects with normal fasting glucose and normal glucose tolerance were included in the study. Anthropometrical and biochemical parameters were examined using standard methods. The updated NECP criteria were used to define the MetS. Values of SUA above the sex-specific percentile 75 were used to define hyperuricemia. The prevalence of general and abdominal obesity, hypertension, hypertriglyceridemia, low-HDL, smokers, MetS and insulin resistance was significantly greater in the fourth SUA quarti... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4141244 Wed, 03 Nov 2010 07:44:37 +0100 4141244 http://www.medworm.com/index.php?rid=4135891&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl1758q2076884v67%2F Abstract  The insulin-like growth factor (IGF) system plays essential role in the regulation of cell growth, proliferation and survival and affects nearly every organ system in the body. IGF-I, which has a high structural similarity to insulin, exerts growth-promoting effects, influences glucose metabolism and has neuroprotective and cardioprotective effects, partly because of its cell-proliferative and antiapoptotic properties. Aberrations in the IGF system may associate with various pathological conditions, including cancer. Insulin and its synthetic analogs are known to possess IGF-IR binding affinity, and concern has been raised about their mitogenic potential in humans. The present review summarizes the main aspects of the IGF system biology and the interactions among ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4135891 Tue, 02 Nov 2010 15:17:40 +0100 4135891 http://www.medworm.com/index.php?rid=4127624&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flpv31m7334734256%2F Abstract  We investigated the measurement of insulin sensitivity (S I) with a standardized hyperglucidic breakfast (SHB) compared to minimal model analysis of an intravenous glucose tolerance test (S I-IVGTT) in 17 patients clinically referred as type 2 diabetics, not yet treated by insulin, and representing a wide range of body mass index and S I. To classify the patients, ten meal-tolerance test-based calculations of S I (MTT-S I) were compared to S I-IVGTT, and their reference values and distribution were measured on a separate sample of 200 control SHBs and 209 control IVGTTs. Eight MTT-SI indices exhibit significant correlations with S I-IVGTT: Mari’s OGIS index, BIGTT-SI|0–30–120, BIGTT-SI|0–60–120, 1/G b I m, Caumo’s oral minimal model (OMM), Sluit... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4127624 Thu, 28 Oct 2010 07:45:09 +0100 4127624 http://www.medworm.com/index.php?rid=4090184&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F912525571866687v%2F We report a case of a 61-year-old man with an atopic background and affected by diabetes mellitus type 2 since 27 years, who experienced generalized allergy to insulin at the moment of switching oral anti-diabetics to insulin. Prick tests revealed an allergy specifically to zinc, and the patient was treated with zinc-free glulisine insulin. After 8 months of such treatment, patient’s glucose is stable and he never experienced allergic reactions to insulin injections. Even insulin allergy due specifically to zinc is rare, such complication must be assessed especially in a patient suffering from multiple allergies. Content Type Journal ArticleDOI 10.1007/s00592-010-0230-4Authors Ines Ben Ammar, Service de Diabétologie et Nutrition, Institut National de Nutrition, Tun... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4090184 Wed, 20 Oct 2010 17:56:27 +0100 4090184 http://www.medworm.com/index.php?rid=4090185&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq3p12u746kl410w3%2F The objective of this study is to examine the efficacy and tolerability of miglitol with respect to improving glycemic control in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylurea treatment. This was a randomized, double-blinded, placebo-controlled, multicenter study. A total of 105 patients were randomized to receive 24 weeks of treatment with miglitol (n = 52; titrated from 50 mg to 100 mg 3 times daily) or placebo (n = 53). Concomitant sulfonylurea treatment and diet remained unchanged. The primary endpoint was change in glycated hemoglobin (HbA1c) from baseline at 24 weeks. Secondary endpoints were changes in fasting plasma glucose (FPG), postprandial plasma glucose (PPG), and postprandial serum ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4090185 Wed, 20 Oct 2010 17:56:26 +0100 4090185 http://www.medworm.com/index.php?rid=4090187&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd215836263t71062%2F Abstract  Aerobic capacity, as indicated by maximal oxygen uptake (VO2 max) has an important role in contrasting the traditional cardiovascular risk factors and preventing cardiovascular morbidity and mortality. It is known that endothelial function, measured as flow-mediated dilation (FMD) of the brachial artery, is strictly linked to atherogenesis and cardiovascular risk. However, the relationship between VO2 max and FMD has not been fully investigated especially in healthy non-obese subjects. This preliminary study cross-sectionally investigated the relationship between VO2 max and FMD in 22 non-obese, healthy sedentary male subjects. Dividing the cohort in two subgroups of 11 subjects each according to the median value of VO2 max, the FMD was significantly lower in the su... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4090187 Sat, 16 Oct 2010 08:36:56 +0100 4090187 http://www.medworm.com/index.php?rid=4090186&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmn0hk3214q28r296%2F In conclusion, because our study suggests LADA subgroups in Korea appear to have a faster decline in C-peptide levels, it is worth detecting the patients with LADA early and effort to preserve beta cell function. Furthermore, our results showed that the prevalence of microvascular complication was comparable between the subgroups. Content Type Journal ArticleDOI 10.1007/s00592-010-0228-yAuthors Mi-Oh Roh, Department of Internal Medicine, Division of Endocrinology and Metabolism, Soonchunhyang University School of Medicine, # 108 Jung-Dong, Wonmi-Ku, Kyunggi-Do, Bucheon, 110-746 Republic of KoreaChan-Hee Jung, Department of Internal Medicine, Division of Endocrinology and Metabolism, Soonchunhyang University School of Medicine, # 108 Jung-Dong, Wonmi-Ku, Kyunggi-Do, Bucheon, 110-7... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=4090186 Sat, 16 Oct 2010 08:36:56 +0100 4090186 http://www.medworm.com/index.php?rid=3995472&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh63185215601k888%2F Abstract  To explore the clinical significance of seven diabetes-related serum microRNAs (miR-9, miR-29a, miR-30d, miR34a, miR-124a, miR146a and miR375) during the pathogenesis of type 2 diabetes (T2D), 56 subjects were recruited to this study: 18 cases of newly diagnosed T2D (n-T2D) patients, 19 cases of pre-diabetes individuals (impaired glucose tolerance [IGT] and/or impaired fasting glucose [IFG]) and 19 cases of T2D-susceptible individuals with normal glucose tolerance (s-NGT). Serum miRNAs were determined by real-time RT-PCR. Expression levels of single miRNAs and the expression signatures of miRNAs as a panel were analysed among the three groups. In n-T2D, all 7 miRNAs were significantly up-regulated compared with s-NGT and five were significantly up-regulated compar... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3995472 Mon, 20 Sep 2010 19:49:21 +0100 3995472 http://www.medworm.com/index.php?rid=3995473&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9v43w4k216677263%2F Abstract  Diabetes mellitus (DM) is an important risk factor for accelerated atherosclerosis and increases cardiovascular disease. Several studies found a higher mortality rate in postoperative diabetic patients than in non-diabetic patients. However, other studies found conflicting evidence on bypass graft dysfunction in patients with diabetes mellitus. We therefore investigated the influence of diabetes mellitus on the long-term outcome after coronary artery bypass surgery (CABG). In this prospective study, 936 consecutive CABG patients were included. These patients were divided into three groups: patients without diabetes mellitus, patients with diabetes mellitus using oral drugs (non-insulin-treated DM) and patients with diabetes mellitus using insulin (insulin-treated ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3995473 Mon, 20 Sep 2010 19:49:16 +0100 3995473 http://www.medworm.com/index.php?rid=3981533&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7448435395671r8k%2F Abstract  In skeletal muscle cells, insulin stimulates cytoskeleton actin remodeling to facilitate the translocation of glucose transporter GLUT4 to plasma membrane. Defect of insulin-induced GLUT4 translocation and actin remodeling may cause insulin resistance. Free fatty acids cause insulin resistance in skeletal muscle. The aim of this study was to investigate the effects of fatty acids on glucose transport and actin remodeling. Differentiated L6 muscle cells expressing c-myc epitope-tagged GLUT4 were treated with palmitic acid, linoleic acid and oleic acid. Surface GLUT4 and 2-deoxyglucose uptake were measured in parallel with the morphological imaging of actin remodeling and GLUT4 immunoreactivity with fluorescence, confocal and transmission electron microscopy. Differ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3981533 Fri, 17 Sep 2010 06:44:48 +0100 3981533 http://www.medworm.com/index.php?rid=3978395&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm3720367u81m3lj1%2F Abstract  To examine the long-term predictive power of heart rate variability (HRV) on all-cause mortality in randomly selected diabetic individuals. A total of 240 diabetic persons were randomly selected from the diabetic population. A 24-h ECG was obtained for each person included and analysed on the Pathfinder 700. In the RR Tools Program time (SDNN, SDANN, SDNN index, RMSSD, NN50, Triangular index) and frequency domain parameters (total power, VLF, LF, LFnorm, HF, HFnorm, HF/LF) were computed. After 15½ years vital statistics were obtained. The analysis included 165 persons with acceptable ECG recordings. 81 individuals (49%) died during follow-up. Correcting for age and gender we found that in time domain, only the SDNN index was a significant mortality predictor... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3978395 Thu, 16 Sep 2010 05:53:15 +0100 3978395 http://www.medworm.com/index.php?rid=3978396&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft852407808276819%2F Abstract  To investigate the influence of two insulin administration modalities, continuous subcutaneous insulin infusion (CSII) and multiple daily insulin injections (MDI) therapy with insulin analogues, on the development of insulin antibodies (IAs) in patients with type 1 diabetes mellitus and to assess the impact of IAs on glucose control and hypoglycaemia. 96 patients with type 1 diabetes mellitus treated with CSII (n = 48) or MDI (n = 48) were included in the study. Age, duration of diabetes, A1c, preprandial and postprandial blood glucose and hypoglycaemic events were compared between IA positive and negative patients. IA levels were higher in the CSII group (% 24.6 ± 14.2) than the MDI group (% 13.2 ± 9.9). Duration of diabet... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3978396 Wed, 15 Sep 2010 05:47:54 +0100 3978396