MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Acta Diabetologica' source. Fri, 19 Mar 2010 15:17:15 +0100 http://www.medworm.com/index.php?rid=3336643&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkg47n0104872v641%2F Abstract  Diabetic cardiomyopathy has been defined as “a distinct entity characterized by the presence of abnormal myocardial performance or structure in the absence of epicardial coronary artery disease, hypertension, and significant valvular disease”. The diagnosis stems from the detection of myocardial abnormalities and the exclusion of other contributory causes of cardiomyopathy. It rests on non-invasive imaging techniques which can demonstrate myocardial dysfunction across the spectra of clinical presentation. The presence of diabetes is associated with an increased risk of developing heart failure, and the 75% of patients with unexplained idiopathic dilated cardiomyopathy were found to be diabetic. Diabetic patients with microvascular complications show the stronges... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3336643 Wed, 03 Mar 2010 08:51:18 +0100 3336643 http://www.medworm.com/index.php?rid=3336642&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu34q66580321196r%2F Abstract  To investigate fructose concentrations in diabetic patients with ketoacidosis or ketosis, serum fructose concentrations and daily urinary fructose excretion were measured in 23 patients with ketoacidosis (n = 16) and ketosis (n = 7) on the first day of admission. Seventeen patients were diagnosed with type 1, one patient with mitochondrial, and 4 patients with atypical diabetes. In 16 of the 23 patients, serum and urinary fructose could be assessed after starting treatments. Mean serum fructose concentration was 71.6 ± 108.1 μmol/l, and mean daily urinary fructose excretion was 352.1 ± 473.7 μmol/day. Serum fructose levels in patients with atypical diabetes were much higher (205.0 ± 213.3 μmol/l)... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3336642 Wed, 03 Mar 2010 08:51:18 +0100 3336642 http://www.medworm.com/index.php?rid=3315542&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F45k686283312p890%2F In conclusion, we propose that IL18 has a specific role that contributes more closely to the progression of diabetic nephropathy than other diabetic complications. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-010-0178-4Authors Takayuki Fujita, Nihon University School of Medicine Department of Nephrology, Hypertension and Endocrinology 30-1 Oyaguchi-Kamimachi Itabashiku, Tokyo 173-8610 JapanNorikazu Ogihara, Nihon University School of Medicine Department of Diabetes and Metabolism 30-1 Oyaguchi-Kamimachi Itabashiku, Tokyo JapanYumi Kamura, Nihon University School of Medicine Department of Ophthalmology 30-1 Oyaguchi-Kamimachi Itabashiku, Tokyo JapanAtsushi Satomura, Nihon University School of Medicine Department of Laboratory Medicine 30-1 Oyaguchi-Kamimac... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3315542 Fri, 26 Feb 2010 06:45:20 +0100 3315542 http://www.medworm.com/index.php?rid=3241247&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu764uv712404q34n%2F Abstract  To determine the feasibility of a sleep apnea screening program in Romanian patients with type 2 diabetes and obesity attending outpatient clinic of a diabetes center (the standard for routine care in Romania). The Epworth Sleepiness Scale was administered to 80 consecutive patients with type 2 diabetes and a body mass index (BMI) ≥30 kg/m2. Patients with a score >10 at this scale were referred to polysomnography for a sleep study. Overall, 20% of these patients had excessive daytime sleepiness (Epworth Sleepiness Scale >10), and in all of these cases, obstructive sleep apnea was confirmed. Of these patients, 33.3% had moderate OSA (AHI = 15–30 events/h of sleep), and 58.3% had severe OSA (AHI ≥30 events/h of sleep). Individuals with OSA ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3241247 Wed, 03 Feb 2010 17:53:31 +0100 3241247 http://www.medworm.com/index.php?rid=3241246&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu48758h78m0026r7%2F Abstract  In addition to chronic hyperglycemia, insulin resistance itself has been proposed to cause a diabetic neuropathy. We evaluated the role of insulin resistance in the pathogenesis of peripheral and autonomic neuropathy in patients with type 2 diabetes. Eighty-six patients with type 2 diabetes were evaluated for the anthropometric and biochemical profiles, and Kitt value was calculated from insulin tolerance test to assess the insulin resistance. Various autonomic function tests, nerve conduction velocity, and quantitative sensory tests were performed to assess autonomic and peripheral neuropathy. In univariate analysis, both autonomic and peripheral neuropathy were significantly associated with glycemic exposure index (GE index), HDL-cholesterol, duration of DM, and... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3241246 Wed, 03 Feb 2010 17:53:31 +0100 3241246 http://www.medworm.com/index.php?rid=3206138&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff112675j77565547%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s00592-010-0175-7Authors Robert C. Atkins, Monash University Department of Epidemiology and Preventive Medicine 89 Commercial Road Melbourne 3004 AustraliaPaul Zimmet, Baker IDI Heart and Diabetes Institute 250 Kooyong Road Caulfield VIC 3162 Australia Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3206138 Sat, 23 Jan 2010 07:41:32 +0100 3206138 http://www.medworm.com/index.php?rid=3206139&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmm858nm7n5700474%2F Abstract  Only few insulin-treated (IT) people with diabetes mellitus (DM) reach the target due to poor compliance and/or to sedentary lifestyle and/or to inadequate treatment regimen. The latter may be also brought about by often overlooked factors including insulin injection into altered skin areas, often brought about by incorrect habits, namely needle reutilization or poor compliance to the suggestion to continuously rotate skin injection areas. The aim of our study was to evaluate the rate of skin lesions within the sites commonly used for insulin injection in our IT DM patients and to verify whether a short-acting insulin analogue yielded different metabolic effects when injected in altered vs. normal skin areas. One hundred and eighty well-trained IT people with type... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3206139 Fri, 22 Jan 2010 03:01:22 +0100 3206139 http://www.medworm.com/index.php?rid=3161013&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4662448705482096%2F In conclusion, the SSAO activity increased in the serum and decreased in the arterial tissue. These findings suggest damage in the vascular tissue and support the hypothesis that serum SSAO may be a useful biochemical marker for diabetes. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00592-009-0174-8Authors Sandra Fernanda Nunes, Coimbra University Laboratory of Pharmacology, Faculty of Pharmacy 3000-548 Coimbra PortugalIsabel Vitoria Figueiredo, Coimbra University Laboratory of Pharmacology, Faculty of Pharmacy 3000-548 Coimbra PortugalJoão Santos Pereira, Portuguese Oncology Institute of Coimbra Coimbra PortugalPaulo João Soares, São José Laboratory Coimbra PortugalMaria Margarida Caramona, Coimbra University Laboratory of Pharmacology, Faculty of Pharmac... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3161013 Sat, 09 Jan 2010 08:25:00 +0100 3161013 http://www.medworm.com/index.php?rid=3161014&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F30414731vrmr1kp4%2F In conclusion, DWB might be a tool potentially helping to improve glycemic control in T1DM adult users of insulin pumps. Male patients and those with a shorter duration of diabetes seem to use it more willingly. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0173-9Authors Tomasz Klupa, Jagiellonian University, Medical College Department of Metabolic Diseases 15 Kopernika Street 31-501 Krakow PolandJan Skupien, Section on Genetics and Epidemiology, Joslin Diabetes Center Boston MA USAKatarzyna Cyganek, Jagiellonian University, Medical College Department of Metabolic Diseases 15 Kopernika Street 31-501 Krakow PolandBarbara Katra, Jagiellonian University, Medical College Department of Metabolic Diseases 15 Kopernika Street 31-501 Krakow PolandJacek Sieradzki... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3161014 Fri, 08 Jan 2010 21:37:46 +0100 3161014 http://www.medworm.com/index.php?rid=3161015&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj7v0v258xj977q13%2F This study was designed to investigate plasma circulating pro-inflammatory cytokines, adiponectin and high-sensitive C-reactive protein (hsCRP) in young men with type 2 diabetes. New-onset young men with type 2 diabetes (young diabetes, YDM; age between 10 and 25) were recruited and divided into a non-obese group (NOYDM, body mass index, BMI ≦ 25 kg/m2, N = 23) and an obese group (OBYDM, BMI ≧ 25 kg/m2, N = 24). Twenty-four non-obese non-diabetic young men served as controls. Hemoglobin A1c, fasting glycemic index, lipids, adiponectin, hsCRP, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined. Insulin sensitivity and β-cell function were calculated using the homeostasis model assessment method (HOMA-IR and H... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3161015 Fri, 08 Jan 2010 09:09:23 +0100 3161015 http://www.medworm.com/index.php?rid=3064569&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg23w160114704r32%2F Abstract  Herbal medicine and medical plants such as Ziziphus vulgaris L. are widely used for the treatment of diseases such as diabetes mellitus. We investigated the effects of water extracts of Ziziphus vulgaris L. fruit on serum glucose, triglycerides, LDL-cholesterol, HDL-cholesterol and activities of aminotransferase enzymes inreptozocin-induced diabetic adult male rats. Continuous supplementation of this water extract by gavage at doses of 0.25, 0.5, 1, 1.5 and 2 g/kg in 0.5 ml distilled water in diabetic rats resulted in a significant decrease of fasting blood glucose and LDL-cholesterol and triglyceride levels after 14 days. The levels of HDL-cholesterol and insulin, and activities of serum aminotransaminase enzymes, alanine aminotransferase and aspart... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3064569 Thu, 03 Dec 2009 18:21:19 +0100 3064569 http://www.medworm.com/index.php?rid=3041295&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0u31484w42365q51%2F In conclusion, honey, because of its lower GI and PII when compared with sucrose, may be used as a sugar substitute in patients with type 1 diabetes mellitus. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0167-7Authors Mamdouh Abdulrhman, Ain Shams University Department of Pediatrics Cairo EgyptMohamed El-Hefnawy, National Institute of Diabetes Cairo EgyptRasha Hussein, Ain Shams University Department of Pediatrics Cairo EgyptAhmad Abou El-Goud, Ain Shams University Department of Pediatrics Cairo Egypt Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3041295 Thu, 26 Nov 2009 07:59:31 +0100 3041295 http://www.medworm.com/index.php?rid=3041296&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8202086543150324%2F Abstract  The role of hyperhomocysteinemia as a risk factor for diabetic long-term complications has not been sufficiently evaluated in prospective studies, considering specific correlates of homocysteine (tHcy) concentration and traditional cardiovascular disease (CVD) risk factors. Fasting tHcy, vitamin B12 and folate plasma levels, the common methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, as well as clinical and lifestyle information were assessed in 216 type 2 diabetic patients attending two outpatient clinics, who had a follow-up evaluation at 65 ± 9 months for the incidence of macroangiopathy. At basal evaluation, mild hyperhomocysteinemia (tHcy ≥ 15 μmol/l) was diagnosed in 21.3% of participants. At follow-up, hy... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3041296 Wed, 25 Nov 2009 16:50:29 +0100 3041296 http://www.medworm.com/index.php?rid=3020330&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6045926862u64241%2F Abstract  The aim of this study is to test the psychometric properties and the responsiveness of the original (status) version of Turkish DTSQ. The study sample included 88 patients with diabetes mellitus who were evaluated in three consecutive time points. The first data collection time point was during their initial contact to the clinic, and the two following (3rd month and 6th month) were during the monitoring visits to the Celal Bayar University Endocrinology Department in 2007. After the adaptation of the DTSQ to Turkish language by following standard procedures, this instrument was applied to the patients along with WBQ-12 and World Health Organization Quality of Life Measure (WHOQOL-Bref). The reliability of the DTSQ was evaluated by running internal consistency ana... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3020330 Sat, 21 Nov 2009 08:30:48 +0100 3020330 http://www.medworm.com/index.php?rid=3020331&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm02510m0h2u6815p%2F Abstract  Based on the hypothesis that a more efficient glucose utilization lowers the risk of progression to type 2 diabetes, we tested the capability of oral glucose tolerance test (OGTT) to identify subjects at risk included inside normal glucose tolerance (NGT). We measured fasting and 2-h plasma glucose (FPG and 2hPG) and insulin values (FPI and 2hPI) in 623 normal OGTTs. Insulin sensitivity and secretion were computed with HOMA2 method and Stumvoll’s formula. Secretion was expressed as HOMA2%β, first (1stPH) and second-phase (2ndPH) insulin release. The percentage increment of 2hPG with respect to FPG (PG%) was used to subdivide patients into PG% tertiles, considered as the primary grouping variable. Covariance analysis (ANCOVA) for multiple comparisons was perform... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3020331 Sat, 21 Nov 2009 08:30:47 +0100 3020331 http://www.medworm.com/index.php?rid=3016260&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbr433616t82t7707%2F Abstract  The aim of this study was to evaluate the role of endoplasmic reticulum (ER) stress in diabetic retinopathy (DR) using in vitro and in vivo models. For the in vivo studies, diabetes was induced in rats, and retinal expression of glucose-regulated protein 78 (GRP78), activating transcription factor 4 (ATF4), C/EBP homologous protein (CHOP), and vascular endothelial growth factor (VEGF) in groups of rats at 1, 3, and 6 months was assessed. For the in vitro studies, human retinal capillary endothelial cells (HRCECs) were cultured in the presence of varying glucose concentrations, and the expression of mRNA and protein for GRP78, ATF4, CHOP, and VEGF was assessed. The chosen glucose concentrations were reflective of those apparent in diabetic patients. Expression... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3016260 Thu, 19 Nov 2009 07:47:09 +0100 3016260 http://www.medworm.com/index.php?rid=3016261&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft273121642712657%2F In this study, we examined the effects of serum uric acid (UA) levels on these glycemic markers. One hundred and ninety-three men with normal glucose tolerance were enrolled in this study. Association of serum UA with BMI, plasma glucose (PG), high sensitivity CRP (hs-CRP), serum GA and HbA1C was analysed. Serum UA showed a significant positive correlation with BMI (R = 0.329, P < 0.0001) and hs-CRP (R = 0.306, P < 0.0001). Multivariate analysis revealed serum UA to be a significant positive explanatory variable for hs-CRP. There was a significant positive correlation of serum UA with the 2-h PG after 75 g OGTT but not fasting PG. Although there was no correlation of serum UA with HbA1C, serum UA showed a significant inverse correlatio... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=3016261 Thu, 19 Nov 2009 07:47:08 +0100 3016261 http://www.medworm.com/index.php?rid=2968782&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F40914j681234nq63%2F Content Type Journal ArticleCategory AnnouncementDOI 10.1007/s00592-009-0155-yAuthors Gaetano Crepaldi, The G.B. Morgagni Prizes, C.N.R. Istituto di Neuroscienze Padova, Sezione Invecchiamento, Via Giustiniani 2 35128 Padua Italy Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 Journal Volume Volume 46 Journal Issue Volume 46, Number 4 / December, 2009 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2968782 Wed, 04 Nov 2009 22:02:53 +0100 2968782 http://www.medworm.com/index.php?rid=2960907&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu1g062h5t9145523%2F We examined the association of rs7903146 variant in the transcription factor 7 like 2 gene (TCF7L2) with T2DM in 333 Palestinian subjects (219 were type 2 diabetic patients and 114 normoglycemic subjects). The rs7903146 variant of TCF7L2 significantly increased T2DM risk with an allelic odds ratio of 3.34 (95% CI [1.99–5.60], P < 0.0001). No significant association was observed between TCF7L2 genotypes and covariates of age, gender and BMI or any tested metabolic trait (total cholesterol and fasting plasma glucose) in both diabetic and nondiabetic individuals (P > 0.05). Among the diabetic group, the TT genotype carrier have earlier age at diagnosis compared with CC and CT carriers (P = 0.013). This is the first study conducted on this gene in the ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2960907 Tue, 03 Nov 2009 09:49:46 +0100 2960907 http://www.medworm.com/index.php?rid=2952126&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F246q52m035015714%2F Abstract  To investigate the influence of breviscapine on the cardiac structure and function in diabetic cardiomyopathy rats as well as the expression of protein kinase C (PKC) and Ca2+-cycling proteins expression. Diabetes was induced in male Sprague–Dawley rats by a single intraperitoneal injection of streptozotocin and the control rats were injected with saline. After the induction of diabetes for 4 weeks, the animals were divided into different groups: (1) normal rats as control; (2) diabetic rats; (3) diabetic rats with administration of breviscapine (10 or 25 mg kg−1 day−2). After treatment with breviscapine for 6 weeks, the invasive cardiac function and echocardiographic parameters were measured, and heart tissue was obtained for electro... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2952126 Fri, 30 Oct 2009 18:31:12 +0100 2952126 http://www.medworm.com/index.php?rid=2947928&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc0405511378nj657%2F Abstract  Increasing evidence suggests that a restricted caloric intake extends the life span of mammals, and SIRT1 may play a key role in this process. To study the effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats, we first induced a model of type 2 diabetes in rats with a low-dose of streptozotocin. Then, the rats were fed with a normal diet, high-fat diet or 60% caloric restriction, respectively. As a result, the apoptosis ratio of islet beta cells in diabetic rats was dramatically increased compared to the control group, and mRNA and protein expression of SIRT1 in islet beta cells were much lower than those of the control group. After caloric restriction for 1 month, the blood glucose and serum insulin of ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2947928 Thu, 29 Oct 2009 19:48:58 +0100 2947928 http://www.medworm.com/index.php?rid=2945256&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F055460lm68v057w1%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s00592-009-0163-yAuthors Magdalena Szopa, Jagiellonian University Department of Metabolic Diseases, Medical College 15 Kopernika Street 31-501 Kraków PolandMalgorzata Malczewska-Malec, Jagiellonian University Department of Clinical Biochemistry, Medical College Kraków PolandBeata Kiec-Wilk, Jagiellonian University Department of Clinical Biochemistry, Medical College Kraków PolandJan Skupien, Jagiellonian University Department of Metabolic Diseases, Medical College 15 Kopernika Street 31-501 Kraków PolandPawel Wolkow, Jagiellonian University Department of Pharmacology, Medical College Kraków PolandMaciej T. Malecki, Jagiellonian University Department of Metabolic Diseases, Medical College 15 Kopernika Street 31-501 Kraków Pol... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2945256 Wed, 28 Oct 2009 20:21:46 +0100 2945256 http://www.medworm.com/index.php?rid=2945257&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0w1234u351174x13%2F Abstract  The association of angiotensin-converting enzyme (ACE) gene polymorphism with diabetic retinopathy (DR) was investigated in many studies with conflicting results. To shed light on these inconclusive findings, a meta-analysis of all available studies relating I (insert)/D (delete) polymorphism to the risk of developing DR was conducted. This meta-analysis included genotype data on 2,342 cases with DR and 2,048 controls free of DR. Summary odds ratios were estimated. Potential sources of heterogeneity and bias were explored. Overall, in allelic genetic model, heterogeneity between studies was nonsignificant (P = 0.12). No publication bias was observed in the regression asymmetry test (τ = 0.84, P = 0.41). There was no significant associa... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2945257 Wed, 28 Oct 2009 20:21:45 +0100 2945257 http://www.medworm.com/index.php?rid=2928673&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft3144k1460365307%2F In conclusion, our data suggest that telmisartan attenuates diabetes-induced impairment of diabetic rat papillary muscles, and may thus be able to reduce cardiac complications in diabetes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0156-xAuthors Mustafa Emre, Cukurova University Department of Biophysics, School of Medicine 01330 Adana TurkeyServet Kavak, Cukurova University Department of Biophysics, School of Medicine 01330 Adana TurkeyHakki Unlugenc, Cukurova University Department of Anesthesiology, School of Medicine Adana Turkey Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2928673 Sat, 24 Oct 2009 05:56:53 +0100 2928673 http://www.medworm.com/index.php?rid=2928674&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa46u04235333r24t%2F Abstract  Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees were at medium to high risk for diabetes type 2, according to the Finrisk score. Hundred and fifty-seven of these individuals underwent oral glucose tolerance testing: 22 were shown to have impaired glucose tolerance (IGT), and 5 had manifest diabetes. Thus, 18% of this worksite sample population were affected by IGT or type 2 diabetes. A total of 87% were affected by metabolic syndrome (MS) according to the International Diabetes Federation (IDF) criteria. At baseline, individuals... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2928674 Sat, 24 Oct 2009 05:56:52 +0100 2928674 http://www.medworm.com/index.php?rid=2928675&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh7q814n01w501235%2F In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial infarction (MI). We used data from the Atherosclerosis Risk in Communities (ARIC) study to examine the incidence of sudden and non-sudden cardiac death and non-fatal MI among persons with and without diabetes in follow-up from the baseline data collection (1987–1989) through December 31, 2001. There were 209 cases of sudden cardiac death, 119 of non-sudden cardiac death, and 739 of non-fatal MI identified in this cohort over an average 12.4 years of follow-up. In analyses adjusted for age, race/ARIC center, gender, and smoking, the Cox proportional hazard ratio of the association of baseline... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2928675 Sat, 24 Oct 2009 05:56:51 +0100 2928675 http://www.medworm.com/index.php?rid=2928677&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F142q7605x83tg071%2F Abstract  The polymorphic enzyme acid phosphatase locus 1 (ACP1) is a candidate gene for obesity disorders. The enzyme is able to dephosphorylate the insulin receptor. Our group has observed a lower plasma glucose level in diabetic subjects carrying the low activity ACP1 phenotypes A and BA, and a positive association between these genotypes and body mass index (BMI). We have now analysed the relationship between BMI and ACP1 in gestational diabetes and in women with type 1 diabetes. We have studied 106 Caucasian women with type 1 diabetes who had previously delivered a liveborn infant, 99 Caucasian women who had had gestational diabetes and 387 healthy fertile women from the same population as controls. ACP1 phenotype was determined by starch gel electrophoresis. In overwe... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2928677 Sat, 24 Oct 2009 05:56:50 +0100 2928677 http://www.medworm.com/index.php?rid=2928676&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9p63242083161j74%2F In this study, we tested the hypothesis that the CHEK2 gene contains one or more polymorphic variants that are associated with type 2 diabetes in HyperGEN individuals. In addition, we replicated our findings in two other Family Blood Pressure Program (FBPP) populations and in the population-based Atherosclerosis Risk in Communities (ARIC) study. We genotyped 1,584 African-American and 1,531 white HyperGEN participants, 1,843 African-American and 1,569 white GENOA participants, 871 African-American and 1,009 white GenNet participants, and 4,266 African-American and 11,478 white ARIC participants for four single nucleotide polymorphisms (SNPs) in CHEK2. Using additive models, we evaluated the association of CHEK2 SNPs with type 2 diabetes in participants within each study population str... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2928676 Sat, 24 Oct 2009 05:56:50 +0100 2928676 http://www.medworm.com/index.php?rid=2928678&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgg2n82x101376w68%2F Abstract  Little information is available on the management of patients with type 2 diabetes mellitus (DM2) in regular clinical practice, prior to and at the point of initiating treatment with insulin. The INSTIGATE study provides a description of the clinical profile of the patient with DM2 who begins treatment with insulin in both primary and secondary care. A total of 224 patients who had been diagnosed with DM2, were not responding to oral treatment, and began receiving insulin were included in the INSTIGATE study in Spain. Demographic data were collected, as well as data on macro- and microvascular complications of diabetes and comorbidities, past medical history of diabetes and oral treatment administered, the clinical severity of diabetes (HbA1c concentration) and in... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2928678 Sat, 24 Oct 2009 05:56:48 +0100 2928678 http://www.medworm.com/index.php?rid=2848330&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe21n46475wnh1142%2F Abstract  The aim of the study is to identify the clinical characteristics of Japanese patients with young-onset type 2 diabetes (YT2D). Family history of diabetes and clinical data were collected for 30 unrelated males (from 11 to 20 years old at age of onset) and 20 females (from 10 to 20 years old at age of onset) with YT2D diagnosed at ≤20 years of age. Fasting C-peptide levels were measured in all, and glucagon stimulation tests were performed twice in six of them over several years. Moreover, 858 people with type 2 diabetes (T2D) diagnosed at >20 years of age were randomly recruited in order to compare the transmission pattern of them. Among the study subjects, 68% reported at least one parent with diabetes. Diabetes was more frequent among mo... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2848330 Tue, 29 Sep 2009 07:33:35 +0100 2848330 http://www.medworm.com/index.php?rid=2848331&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F631427qr765508w6%2F Abstract  Because T2DM increases the risk of coronary atherosclerosis and CAD and new noninvasive techniques to assess CVD risk have gained considerable popularity, it is important to know how these tools relate to each other. The aim of this study was to evaluate the relationship between the extent of coronary artery calcification measured by MDCT, plasma OPG levels, baPWV and the established cardiovascular risk factors in Korean patients with T2DM. From November 2006 to December 2007, 110 asymptomatic Korean patients with T2DM without prior evidence of CAD were assessed (mean age 57.2 years). CAC imaging was performed using a 40-slice MDCT. Serum OPG levels were measured by an enzyme-linked immunosorbent assay (Oscotec, Korea) from the serum samples of each subject. ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2848331 Tue, 29 Sep 2009 07:33:34 +0100 2848331 http://www.medworm.com/index.php?rid=2848332&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh0qx560348630l61%2F In conclusion, given that general DNA damage was similar in the three groups of patients with DM2 and the control group, it is possible that these cells showed similar oxidative damage, as has been proposed previously. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0149-9Authors Emma Ibarra-Costilla, Instituto Mexicano del Seguro Social (IMSS) Unidad de Medicina Familiar No. 46 Monterrey MexicoRicardo M. Cerda-Flores, Centro de Investigación Biomédica del Noreste, IMSS División de Genética Administración de Correos No 4. Apartado postal 20 C. P. 64720 Monterrey NL MexicoMartha I. Dávila-Rodríguez, Centro de Investigación Biomédica del Noreste, IMSS División de Genética Administración de Correos No 4. Apartado postal 20 C. P. 64720 Monterrey NL... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2848332 Tue, 29 Sep 2009 04:06:21 +0100 2848332 http://www.medworm.com/index.php?rid=2848333&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1687v52457871837%2F Abstract  The aim of this article is to investigate the relation of the anti-inflammatory effect of pioglitazone with cardiac autonomic function and metabolic control in diabetic patients. In this prospective open label trial, 36 type 2 diabetic patients (age 60 ± 10, 20 M) without overt cardiovascular disease were randomized to add pioglitazone (30 mg) to their therapy or to continue standard therapy. C-reactive protein (CRP) serum levels, metabolic parameters and cardiac autonomic function (assessed by heart rate variability [HRV] on 24-h ECG Holter monitoring) were measured at baseline and after 3 months. Clinical and laboratory variables were similar in the two groups. No significant changes were observed after 3 months for metabolic and an... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2848333 Tue, 29 Sep 2009 04:06:20 +0100 2848333 http://www.medworm.com/index.php?rid=2848334&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg032847101733211%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s00592-009-0147-yAuthors Ana Beatriz Valverde Mendes, São Paulo Federal University Rua Botucatu, 740 São Paulo 04023-900 BrazilJoão Antônio Saraiva Fittipaldi, Pfizer Inc. Rua Alexandre Dumas 1860, Chácara Santo Antonio São Paulo 04717-904 BrazilRaimundo Celestino Silva Neves, Oswaldo Cruz Foundation, Brazilian Ministry of Health Gonçalo Moniz Research Center Rua Waldemar Falcão 121, Salvador Bahia 40296-710 BrazilAntônio Roberto Chacra, São Paulo Federal University Rua Botucatu, 740 São Paulo 04023-900 BrazilEdson Duarte Moreira, Oswaldo Cruz Foundation, Brazilian Ministry of Health Gonçalo Moniz Research Center Rua Waldemar Falcão 121, Salvador Bahia 40296-710 Brazil Journal Acta DiabetologicaOnline ISSN 1432... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2848334 Tue, 29 Sep 2009 04:06:18 +0100 2848334 http://www.medworm.com/index.php?rid=2848335&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj01540p3n07462tt%2F Abstract  The aim of this study is to establish whether abnormal mineral metabolism is present in patients with type 1 DM with normal renal function and in the absence of microalbuminuria. Serum levels of 1,25-dihydroxyvitamin D, osteoprotegerin (OPG) and receptor activator for nuclear factor kappa β ligand (RANKL) and other determinants of bone metabolism were measured in 35 patients with type 1 DM and in 25 age-, sex- and ethnicity-matched healthy controls. Serum OPG (1.98 vs. 2.98 pmol/l: P = 0.001), 1,25-dihydroxyvitamin D (41.1 vs. 48.2 pmol/l: P = 0.035) and magnesium (0.84 vs. 0.89 mmol/l P = 0.029) levels were significantly lower in patients with type 1 DM compared to normal controls. RANKL levels were similar in both grou... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2848335 Tue, 29 Sep 2009 01:07:06 +0100 2848335 http://www.medworm.com/index.php?rid=2835121&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F10543m7186rm6402%2F Abstract  Whether ageing is associated with increased fibrinogen concentration and production remains unclear. We measured fibrinogen fractional (FSR) and absolute synthesis (ASR) rates in male volunteers, of either young (mean age: 28 years, range: 22–34) or middle age (mean age: 57 years, range: 38–72), using a leucine-tracer isotope dilution technique. In the middle-age group, neither fibrinogen FSR (20.8 ± 1.6%/day) nor ASR (1.8 ± 0.1 g/day), or concentration (274 ± 15 mg/dl), were different from those of the younger group (FSR: 20.2 ± 1.4; ASR: 1.7 ± 0.2; concentration: 265 ± 8, respectively). Leucine Ra, an index of endogenous proteolysis, was ≈20% lower in the older than in the younger g... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2835121 Thu, 24 Sep 2009 14:32:44 +0100 2835121 http://www.medworm.com/index.php?rid=2835122&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F046q7448u6q12765%2F This study was designed to estimate the risk of developing diabetes in relation to adult height components, namely leg length and leg length/height ratio. Data on 12,800 individuals without diabetes were obtained at the baseline examination from the ARIC cohort. Cox proportional hazard models were used to estimate hazard rate ratios of diabetes for each 5-cm difference in leg length and 1 SD difference in the leg length/height ratio. During a mean follow-up period of 7.6 years, the age-adjusted incidence per 1,000 person years of follow-up was 25.8, 24.2, 10.4, and 16.2 in African American (AA) women, AA men, white women, and white men, respectively. The hazard ratio for diabetes (95% CI) per 5-cm difference in leg length was 0.85 (0.75–0.95) in white men, 0.79 (0.69–0.90) i... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2835122 Thu, 24 Sep 2009 14:32:43 +0100 2835122 http://www.medworm.com/index.php?rid=2833295&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F595147135jmk2242%2F Abstract  Insulin-like growth factor (IGF) binding proteins (IGFBPs) moved on to contain both IGF high- and low-affinity binders, exerting mitogenic and metabolic actions through its complex interplay between IGF/insulin and its IGF/insulin-independent manner. Progress on the metabolic-related function of IGFBPs has been rapid in recent years. A wealth of studies in 3T3-L1 adipocytes and the transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and insulin resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components of the metabolic syndrome. Abnormal expression of IGFBP was detected in various states of the metabolic disorders, suggesting that it could be used as a convenient and s... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2833295 Tue, 22 Sep 2009 15:41:47 +0100 2833295 http://www.medworm.com/index.php?rid=2810873&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F735575q011205025%2F In conclusion, intermittent high glucose induced more ROS in PIECs than constant high glucose, this effect seemed to be, at least in part related to the enhanced activation of NADPH oxidase. Glucose fluctuation may be involved in the development of vascular complications. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0140-5Authors Qin-Min Ge, Shanghai Jiaotong University School of Medicine Department of Endocrinology, Xinhua Hospital Shanghai 200092 ChinaYan Dong, Shanghai Jiaotong University School of Medicine Department of Endocrinology, Xinhua Hospital Shanghai 200092 ChinaHong-Mei Zhang, Shanghai Jiaotong University School of Medicine Department of Endocrinology, Xinhua Hospital Shanghai 200092 ChinaQing Su, Shanghai Jiaotong University School of Me... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2810873 Fri, 18 Sep 2009 06:12:55 +0100 2810873 http://www.medworm.com/index.php?rid=2810874&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb157754043646580%2F Abstract  The aim of this study is to assess the validity of combined use of fasting plasma glucose (FPG) and glycated hemoglobin A1c (HbA1c) as screening tests for diabetes and impaired glucose tolerance (IGT) in high-risk subjects. A total of 2,298 subjects were included. All subjects underwent a 75-g oral glucose tolerance test (OGTT) and HbA1c measurement. Receiver operating characteristic curve (ROC curve) analysis was used to examine the sensitivity and specificity of FPG and HbA1c for detecting diabetes and IGT, which was defined according to the 1999 World Health Organization (WHO) criteria. (1) Based on the ROC curve, the optimal cut point of FPG related to diabetes diagnosed by OGTT was 6.1 mmol/l that was associated with a sensitivity and specificity of 81.5... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2810874 Thu, 17 Sep 2009 12:48:16 +0100 2810874 http://www.medworm.com/index.php?rid=2735769&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F001766596247lv63%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s00592-009-0141-4Authors Alireza Esteghamati, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranArmin Rashidi, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranOmid Khalilzadeh, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranHaleh Ashraf, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranMehrshad Abbasi, Tehran University of Medical Sciences Endocrinology and Metabolism Researc... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2735769 Tue, 25 Aug 2009 16:48:31 +0100 2735769 http://www.medworm.com/index.php?rid=2697429&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6w637w588782555x%2F Abstract  Exact computations of glucose accumulation (GA, mM) and Na anions deficit (ΔNa, mEq) can be obtained in hypo-osmolar hyponatremic hyperglycaemia (HHH), where plasma osmolality (POsm) is lower than normal. In this condition, GA − ΔNa = ∆POsm × TBW (total body water). GA is given by plasma glucose concentration (PG1) times extra-cellular volume (ECV), calculated as TBW − ICV (the known intra-cellular volume). The changes in solute content can then be computed from their concentrations. This model was verified on computer-simulated patients to whom GA was added in variable amounts, lower than those of ΔNa subtracted, generating known ICV, ECV, PNa1, and PG1. True computer-generated values were identical (the correla... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2697429 Wed, 12 Aug 2009 05:52:02 +0100 2697429 http://www.medworm.com/index.php?rid=2679918&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fglp44n58251w6838%2F This study aimed to estimate the prevalence of inadequate glycaemic control and its correlates in a large multicentre survey of Brazilian patients with diabetes. A cross-sectional study was conducted in a consecutive sample of patients aged 18 years or older with either type 1 or type 2 diabetes, attending health centres located in ten large cities in Brazil (response rate = 84%). Information about diabetes, current medications, complications, diet, and satisfaction with treatment were obtained by trained interviewers, using a standardized questionnaire. Glycated haemoglobin (HbA1c) was measured by high-performance liquid chromatography in a central laboratory. Patients with HbA1c ≥ 7 were considered to have inadequate glycaemic control. Overall 6,701 patien... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2679918 Wed, 05 Aug 2009 10:08:10 +0100 2679918 http://www.medworm.com/index.php?rid=2665174&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq832l7757248744w%2F This article investigates the prevalence of metabolic syndrome (MS) and the benefits of lowered body mass index (BMI) cutoff point for assessing MS prevalence in a large, nationally representative population sample comprising of 15,365 Thai adults from metropolitan Bangkok who received annual checkup. Prevalence of MS was characterized using the International Diabetes Federation criteria and BMI ≥25 kg/m2 as cutoff revealed that 26.63% of male and 14.90% of female subjects had MS and the prevalence was age dependent. Traditional BMI cutoff of ≥30 kg/m2 underestimated MS prevalence in Thai population while BMI ≥25 kg/m2 was found to be a suitable solution. Common combinations of MS components were identified in order to find common occurrences that may be implicate... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2665174 Fri, 31 Jul 2009 19:51:52 +0100 2665174 http://www.medworm.com/index.php?rid=2632011&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0278589qx7p07210%2F Abstract  The aim of this study was to assess whether the levels of physical activity before and during early pregnancy are associated with the prevalence of gestational diabetes mellitus (GDM). The study group included 160 puerperas. Among them, 40 (25%) diagnosed as having GDM during their recent pregnancy, whereas the remaining 120 (75%) served as controls. The international physical activity questionnaire (IPAQ-Greek version) was applied twice, in an attempt to estimate the level of physical activity before and during early pregnancy. Women who were “inactive” before or during early pregnancy had odds ratio (OR) 7.9 [95% confidence interval (CI) 3.7–16.56] and 1.3 (95% CI 1.2–1.4) of developing GDM, compared to “minimally active” or “active” women, respec... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2632011 Sat, 18 Jul 2009 21:12:31 +0100 2632011 http://www.medworm.com/index.php?rid=2578185&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa230352766x36701%2F Abstract  It is well known that good metabolic control maintained throughout pregnancy reduces maternal and fetal complications in diabetes. Before conception and throughout pregnancy, insulin therapy needs to be optimized and, in this context, the insulin analogs currently available in the market may help to achieve good metabolic control. We therefore review here what is known about the potential benefits and risks related to the use of these new insulins in pregnancy. Clinical and experimental data on insulin aspart and lispro strongly suggest that they have no adverse maternal or fetal effects during pregnancy in women with pregestational and gestational diabetes, and that their use results in improved glycemic control, fewer hypoglycemic episodes, and improved patient ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2578185 Mon, 06 Jul 2009 17:07:53 +0100 2578185 http://www.medworm.com/index.php?rid=2489504&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu3n73p86v7m4m833%2F This study investigates the parameters affecting IA frequency and binding levels in a cohort of type 1 diabetes (T1D) patients. All patients were treated with human recombinant insulin. About half of the patients had received animal insulin prior to the introduction of human recombinant insulin. We tested the IA frequency and binding level for all serum samples. IA were further analyzed for their epitope specificity comparing human and porcine insulin binding. We found that T1D patients who received animal insulin in the past show significantly higher IA binding levels as compared to patients treated exclusively with human recombinant insulin (IA binding level of 0.9 and 0.25 index, respectively, P = 0.005). T1D patients who received animal insulin in the past showed a relat... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2489504 Tue, 23 Jun 2009 06:15:39 +0100 2489504 http://www.medworm.com/index.php?rid=2489505&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa676654178266832%2F Abstract  The prevalence of diabetes is expected to rise together with an increase in morbidity and a reduction in life expectancy. A leading cause of death is cardiovascular disease, and hypertension and diabetes are additive risk factors for this complication. Selected treatment options should neither increase cardiovascular risk in patients with diabetes, nor increase risk of hyperglycaemia in patients with hypertension. The efficacy of present antihyperglycaemic agents is limited and new therapies, such as incretin-targeted agents, are under development. Even though most patients do not achieve glycated haemoglobin targets, trial data show that such interventions reduce the incidence of macrovascular events; however, intensive lowering may be detrimental in patients wit... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2489505 Sat, 20 Jun 2009 06:04:24 +0100 2489505 http://www.medworm.com/index.php?rid=2489506&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx236060167723l43%2F In conclusion, the data from this study confirmed previous results showing genetic similarities between patients with LADA and type 2 diabetes. Non-autoimmune mechanism may be related to beta cell dysfunction in patients with LADA. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00592-009-0133-4Authors Barbara Szepietowska, Yale University School of Medicine Section of Endocrinology, Department of Internal Medicine New Haven CT USADariusz Moczulski, Medical University of Lodz Department of Internal Medicine and Nephrodiabetology Lodz PolandNatalia Wawrusiewicz-Kurylonek, Medical University of Bialystok Department of Endocrinology, Diabetology and Internal Medicine Białystok PolandWladyslaw Grzeszczak, Silesian School of Medicine in Katowice Department of Interna... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2489506 Wed, 17 Jun 2009 09:43:13 +0100 2489506 http://www.medworm.com/index.php?rid=2465326&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh2829p470448x2k1%2F Abstract  Continuous subcutaneous insulin infusion (CSII) is considered an option for type 1 diabetic patients unsatisfactorily controlled with multiple daily injections (MDI). Short-acting analogs are superior to regular human insulin in CSII. This meta-analysis is aimed at assessing the advantages of short-acting analog-based CSII over MDI in type 1 diabetes. Randomized clinical trials (RCTs) comparing CSII (with analogs) and MDI for at least 12 weeks in type 1 diabetic patients were retrieved, assessing between-group differences in HbA1c and incidence of hypoglycemia. A total of 11 RCTs was included in the analysis. CSII was associated with a significant improvement of HbA1c in comparison with MDI (standardized difference in mean: −0.3 [−0.4;−0.1]%; P <... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2465326 Sat, 06 Jun 2009 11:27:10 +0100 2465326 http://www.medworm.com/index.php?rid=2459987&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd32403136m11k5p4%2F Abstract  The aim is to critically review the more relevant evidence on the interrelationships between exercise and metabolic outcomes. The research questions addressed in the recent specific literature with the most relevant randomized controlled trials, meta-analysis and cohort studies are presented in three domains: aerobic exercise, resistance exercise, combined aerobic and resistance exercise. From this review appear that the effects of aerobic exercise are well established, and interventions with more vigorous aerobic exercise programs resulted in greater reductions in HbA1c, greater increase in VO2max and greater increase in insulin sensitivity. Considering the available evidence, it appears that resistance training could be an effective intervention to help glycemic ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2459987 Thu, 04 Jun 2009 11:17:16 +0100 2459987 http://www.medworm.com/index.php?rid=2449397&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft18754k061304360%2F In conclusion, MetS is independently associated with microalbuminuria in type 2 diabetes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0131-6Authors Alireza Esteghamati, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranArmin Rashidi, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranOmid Khalilzedeh, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranHaleh Ashraf, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Te... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2449397 Fri, 29 May 2009 06:56:41 +0100 2449397 http://www.medworm.com/index.php?rid=2449396&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F312776q726x72575%2F Abstract  Structured exercise is considered an important cornerstone to achieve good glycemic control and improve cardiovascular risk profile in Type 2 diabetes. Current clinical guidelines acknowledge the therapeutic strength of exercise intervention. This paper reviews the wide pathophysiological problems associated with Type 2 diabetes and discusses the benefits of exercise therapy on phenotype characteristics, glycemic control and cardiovascular risk profile in Type 2 diabetes patients. Based on the currently available literature, it is concluded that Type 2 diabetes patients should be stimulated to participate in specifically designed exercise intervention programs. More attention should be paid to cardiovascular and musculoskeletal deconditioning as well as motivation... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2449396 Fri, 29 May 2009 06:56:41 +0100 2449396 http://www.medworm.com/index.php?rid=2449398&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F223078837173116j%2F Abstract  The aim of this study is to assess the oxidative stress status in diabetes mellitus (DM) and diabetic nephropathy. The study group comprised 40 control subjects, 40 type 2 DM patients without complications and 37 diabetic nephropathies. Compared with control subjects, superoxide dismutase, glutathione peroxidase, catalase, vitamin C were decreased (P < 0.01). There was a significant increase in serum malondialdehyde (MDA), conjugated diene (CD), advanced oxidation protein products (AOPP), protein carbonyl (PC) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in diabetes patients when compared with normal subjects (P < 0.01). Moreover, these indexes were much higher in diabetic nephropathy than that of diabetic patients without vascular complicat... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2449398 Thu, 28 May 2009 09:16:09 +0100 2449398 http://www.medworm.com/index.php?rid=2418943&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2w634000wp467337%2F Abstract  Relationship between serum vascular endothelial growth factor (VEGF) level and parameters of endothelial injury and/or dysfunction in patients with diabetes mellitus type 2 with or without microalbuminuria was investigated. Eighty-four diabetic patients were divided in two subgroups (42 each): normoalbuminuric (NAU) and microalbuminuric (MAU). Forty-two blood donors were in control group. Serum VEGF and plasma von Willebrand factor, soluble thrombomodulin, plasminogen activator inhibitor 1, thrombin-activatable fibrinolysis inhibitor (TAFI) and tissue plasminogen activator (t-PA) were measured using enzyme-linked immunosorbent assay in all subjects. VEGF was significantly higher in NAU compared to controls. The difference between MAU and controls was not statistic... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2418943 Wed, 13 May 2009 05:57:14 +0100 2418943 http://www.medworm.com/index.php?rid=2391849&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp26716j50r8160m8%2F In conclusion, serum CRP level is significantly associated with obesity, especially the visceral adipose tissue, and serum leptin is another important independent factor associated with CRP in Korean type 2 diabetic patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0125-4Authors Jong Suk Park, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaMin Ho Cho, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaJi Sun Nam, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaChul Woo Ahn, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaBong Soo Cha, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaEun Ji... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2391849 Tue, 05 May 2009 05:56:13 +0100 2391849 http://www.medworm.com/index.php?rid=2383946&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk8041124566448g1%2F In conclusions, iron metabolism indices influence HbA1C levels, but not serum GA levels, in premenopausal women. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0123-6Authors Masafumi Koga, Kinki Central Hospital Department of Internal Medicine Kuruma-zuka 3-1 Itami Hyogo 664-8533 JapanHiroshi Saito, Kinki Central Hospital Department of Internal Medicine Kuruma-zuka 3-1 Itami Hyogo 664-8533 JapanMikio Mukai, Kinki Central Hospital Department of Internal Medicine Kuruma-zuka 3-1 Itami Hyogo 664-8533 JapanSoeko Matsumoto, Kinki Central Hospital Department of Clinical Laboratory Itami JapanSoji Kasayama, Nissay Hospital Department of Medicine Osaka Japan Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2383946 Thu, 30 Apr 2009 05:57:34 +0100 2383946 http://www.medworm.com/index.php?rid=2383947&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj5012258673g31k6%2F Abstract  Despite growing evidence for a pathogenic role of vascular endothelial growth factor (VEGF) in microvascular complications of diabetes, the underlying mechanism responsible for its detrimental effect remains unknown. In the current study, we hypothesized that some of the detrimental effects of VEGF on microvascular endothelial cells in the diabetic milieu stem from its aberrant signaling, which leads to perturbed tight junction assembly and increased endothelial permeability. Using an integrated in vitro approach, we investigated whether the effect of VEGF on endothelial cell permeability involves Rac1 GTPase activation and tight junction disassembly. Rac1 activity was detected by Western blotting in cell membrane protein as well as pull-down assay. The permeabili... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2383947 Thu, 30 Apr 2009 05:57:32 +0100 2383947 http://www.medworm.com/index.php?rid=2383949&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh122h40144457634%2F We reported on reduced pericyte adhesion to high glucose-conditioned ECM and correction by thiamine. We aimed at verifying the effects of thiamine and benfotiamine on MMP-2, MMP-9 and TIMP expression and activity in human vascular cells with high glucose. In HRP, MMP-2 activity, though not expression, increased with high glucose and decreased with thiamine and benfotiamine; TIMP-1 expression increased with high glucose plus thiamine and benfotiamine; MMP-9 was not expressed. In EC, MMP-9 and MMP-2 expression and activity increased with high glucose, but thiamine and benfotiamine had no effects; TIMP-1 expression was unchanged. Neither glucose nor thiamine modified TIMP-2 and TIMP-3 expression. TIMP-1 concentrations did not change in either HRP or EC. High glucose imbalances MMP/TIMP ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2383949 Thu, 30 Apr 2009 05:57:30 +0100 2383949 http://www.medworm.com/index.php?rid=2383948&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr034483472g9169h%2F Abstract  Diabetes and hypertension are closely related diseases associated with changes in membrane fluidity. Here, we measured the membrane fluidity of erythrocyte ghosts from spontaneously hypertensive rats (SHR), with or without streptozotocin (STZ)-induced diabetes, at the ages of 1, 3 and 6 months, by introducing the use of the intramolecular excimer forming dipyrenylpropane (DPyP) in this model. Type 2 diabetes mellitus (T2DM) was induced in 48-h-old, newborn male SHR by intraperitoneal injection of STZ. We found lower excimer to monomer (I e/I m) DPyP ratios in diabetic SHR than in control SHR at 3 and 6 months old, indicating a decrease in membrane fluidity. Simultaneously, the composition of fatty acids was determined and it was found that the unsaturat... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2383948 Thu, 30 Apr 2009 05:57:30 +0100 2383948 http://www.medworm.com/index.php?rid=2367868&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu03406468074t187%2F Abstract  We evaluated the predictors of the development from normal to impaired glucose tolerance (IGT) in healthy middle-aged Japanese men. Forty male subjects who showed normal glucose tolerance (NGT) levels based on WHO criteria and who had undergone 75-g OGTT annually for 10 years were selected in the database of medical checkups retrospectively, and divided into two groups: those retaining NGT and those that developed IGT. Gamma-glutamyl transpeptidase (GGT) and the glucose levels at 30 and 60 min were significantly associated with the development of IGT in the Cox proportional hazard model. However, other clinical characteristics and the glucose levels at pre-load and at 120 min were not significantly associated with the development of IGT. GGT and the ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2367868 Fri, 24 Apr 2009 07:04:28 +0100 2367868 http://www.medworm.com/index.php?rid=2358206&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl51u535327813247%2F Abstract  Stromal cell-derived factor 1 (SDF-1) is involved in the development of experimental proliferative retinopathy. Since little data are available on the genetic predisposition or on biomarkers predicting the development of proliferative retinopathy, we assessed the distribution of the SDF-1 3′A genotype in 130 diabetic patients with retinopathy. In patients with proliferative retinopathy, the frequency of the homozygous SDF-1 3′A genotype was significantly higher than in patients with non-proliferative retinopathy (10.9% of PDR vs. 0 of NPDR, P = 0.01). This association was confirmed when type 2 diabetes patients were analysed separately (10.3% of PDR vs. 0 of NPDR, P = 0.03). The finding that homozygous carriers of the SDF-1 3′A genotype ar... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2358206 Tue, 21 Apr 2009 11:20:28 +0100 2358206 http://www.medworm.com/index.php?rid=2333381&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk00550542303t723%2F Abstract  The aim of this meta-analysis was to determine the nature of the association between TNF 238 G/A polymorphism and the risk for T2D. We searched databases updated on January 2009 for all publications on the association between this variation and T2D. Data on genotypes and the numbers of cases and controls were assessed using Review Manager 4.2. Meta-analysis of the overall and specific populations was conducted, and odds ratios (OR) and 95% confidence intervals (95% CI) were calculated in the fixed-effect model. I 2 statistic was calculated to examine heterogeneity, and publication bias was evaluated by Egger test. The overall OR (95% CI) for AA and GA genotypes versus GG genotype for TNF-α-238 was 1.15 (0.92–1.44), which in European and Asian populations were 1.... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2333381 Wed, 15 Apr 2009 08:41:16 +0100 2333381 http://www.medworm.com/index.php?rid=2333380&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu8171455n0vr8408%2F Abstract  Microvascular complications are an important cause of morbidity in diabetic patients and can be detected in a significant number of patients at the time of diabetes diagnosis. However, little is known about the alterations in the microvasculature previous to the clinical manifestation of diabetes mellitus type 2. To obtain more insights into the early microvascular deterioration resulting from prediabetes, morphological and functional microvascular parameters were monitored using intravital fluorescence microscopy through a dorsal skin-fold chamber preparation in the uncoupling promotor-driven diphtheria toxin A chain (UCP1/DTA) mice. At the age of 12 weeks, the UCP1/DTA-mice were characterized by impaired glucose tolerance with concurrent unchanged fasting g... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2333380 Wed, 15 Apr 2009 08:41:16 +0100 2333380 http://www.medworm.com/index.php?rid=2333382&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkq6q4033l707281w%2F In conclusion, less common alleles of TAQIB and I405V appear to be modestly associated with obesity risk in an adult Chinese population. Adjustments for HDL levels completely (TAQIB) or partially (I405V) abolished the observed association. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0117-4Authors Xiaoyang Ruan, Beijing Hypertension League Institute Laboratory of Human Genetics Beijing ChinaLina Ma, Beijing Hypertension League Institute Laboratory of Human Genetics Beijing ChinaShuyu Wang, Beijing Hypertension League Institute Laboratory of Human Genetics Beijing ChinaKlaus Lindpaintner, F. Hoffmann-La Roche Roche Center for Medical Genomics Basel SwitzerlandXiangjun Liu, TsingHua University Department of Biomedical Engineering, School of Medicine Beij... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2333382 Fri, 10 Apr 2009 06:20:51 +0100 2333382 http://www.medworm.com/index.php?rid=2333383&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw2046gm718633054%2F In this study, we investigated the effects of APS treatment on cardiac function, myocardial collagen expression, cardiac ultrastructure, cardiac matrix metalloproteinase (MMP) activity, levels of plasma glycosylated serum protein (GSP), and myocardial enzymes, and the expression of Ang II, chymase, and angiotensin-converting enzyme (ACE) in the diabetic hamster myocardium. Diabetes was induced by a single injection of streptozotocin (60 mg/kg ip). The experimental groups consisted of normal control (n = 15), diabetic (n = 15), insulin-treated diabetic (n = 15, NPH 1–2 U/day ip), and APS-treated diabetic (n = 30, APS 1–2 g/kg/day orally for 10 weeks) hamsters. Diabetic hamsters treated with insulin or APS exhibited signific... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2333383 Tue, 07 Apr 2009 05:52:42 +0100 2333383 http://www.medworm.com/index.php?rid=2308387&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4458661mm5u25542%2F Abstract  Hyperglycaemia caused by stress and inflammation is common during critical illness. We hypothesised that a latent glucose metabolism disturbance contributes to development of hyperglycaemia and that those patients have increased risk for diabetes. We included patients with sepsis, acute coronary syndrome and acute heart failure with no history of impaired glucose metabolism and divided them in the hyperglycaemia group (glucose ≥ 7.8 mmol/l) and normoglycaemia group. Patients were followed for 5 years. Follow-up was completed for 115 patients in the normoglycaemia group, of which 4 (3.5%) developed type 2 diabetes. In the hyperglycaemia group 51 patients finished follow-up and 8 (15.7%) developed type 2 diabetes. Relative risk in 5-year period ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2308387 Thu, 02 Apr 2009 05:57:41 +0100 2308387 http://www.medworm.com/index.php?rid=2308388&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F10025q464987815w%2F This study was to determine whether the damage was correlated with expression of the SARS coronavirus receptor, angiotensin converting enzyme 2 (ACE2), in different organs, especially in the endocrine tissues of the pancreas, and to elucidate the pathogenesis of glucose intolerance in SARS patients. The effect of clinical variables on survival was estimated in 135 SARS patients who died, 385 hospitalized SARS patients who survived, and 19 patients with non-SARS pneumonia. A total of 39 SARS patients who had no previous diabetes and received no steroid treatment were compared to 39 matched healthy siblings during a 3-year follow-up period. The pattern of SARS coronavirus receptor-ACE2 proteins in different human organs was also studied. Significant elevations in oxygen saturation, ser... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2308388 Tue, 31 Mar 2009 05:52:40 +0100 2308388 http://www.medworm.com/index.php?rid=2308389&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyj58875581622732%2F Abstract  The aim of the study was to report the prevalence of obesity indices in individuals with diabetes and find out their association with diabetic retinopathy in the urban Indian population. Subjects (n = 1,414) were recruited from Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetics Study (SN-DREAMS-I), a cross-sectional study between 2003 and 2006. Anthropometric measurements were carried out, and all patients’ fundi were photographed using 45° four-field stereoscopic digital photography. The diagnosis of diabetic retinopathy was based on the modified Klein classification. Generalized obesity and abdominal obesity were defined using WHO Asia Pacific guidelines with the BMI (body mass index) cutoff as ≥23 kg/m2, WC (waist cir... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2308389 Fri, 27 Mar 2009 06:52:21 +0100 2308389 http://www.medworm.com/index.php?rid=2308390&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb7g4t05845134286%2F Abstract  The secondary occurrence of type 2 diabetes with various hormonal diseases (e.g. pituitary, adrenal and/or thyroid diseases) is a recurrent observation. Indeed, impaired glucose tolerance (IGT) and overt diabetes mellitus are frequently associated with acromegaly and hypercortisolism (Cushing syndrome). The increased cardiovascular morbidity and mortality associated with acromegaly and Cushing syndrome may partly be a consequence of increased insulin resistance that normally accompanies hormone excess. Acromegalic patients are insulin resistant, both in the liver and in the periphery, displaying hyperinsulinemia and increased glucose turnover in the basal post-absorptive states. The prevalence of diabetes mellitus and that of IGT in acromegaly is reported to range... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2308390 Thu, 26 Mar 2009 08:26:02 +0100 2308390 http://www.medworm.com/index.php?rid=2308391&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb7808h15865q153h%2F Abstract  The aim of this study is to determine the proper initial dose adjustment when switching from multiple daily injections to continuous subcutaneous insulin infusion for type-1 diabetic pediatric patients. Our hypothesis is that the insulin adjustment varies depending on the pubertal status and the previous long-acting insulin used. Charts of 60 patients were reviewed. Data regarding insulin dose, type of insulin administrated, HbA1c, BMI, severe hypoglycemia and DKA events were collected during the previous year and after 6 weeks of pump therapy. In the prepubertal patients the reduction was 19% (26% if the previous insulin used was detemir). Pubertal patients experienced a decrease of 26%, and the detemir group 33%. The ratio long acting-basal/short acting-bol... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2308391 Wed, 25 Mar 2009 07:07:27 +0100 2308391 http://www.medworm.com/index.php?rid=2308392&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb121k69v0021238l%2F Abstract  Patients with type 1 diabetes (a TH1 disease) have been reported to be at a lower risk of developing asthma (a TH2 disease). Both diseases are affected by environmental and genetic factors. Our objective is to examine this relationship in Lebanon, a Middle-Eastern country, where no previous similar studies are available. This is a cross-sectional observational study conducted at the Chronic Care Center, a referral medical center for type 1 diabetics. Patients with type 1 diabetes aged 6–39 years old, their unaffected siblings and age-matched control completed the International Primary Care Airways Group asthma screening questionnaire. The prevalence of asthma symptoms was compared among the three groups and separately within a subgroup of diabetics in relat... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2308392 Wed, 25 Mar 2009 07:07:26 +0100 2308392 http://www.medworm.com/index.php?rid=2287888&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb774603042478261%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00592-009-0111-xAuthors Robert S. Zimmerman, Cleveland Clinic Foundation Cleveland USAKevin Matthew Pantalone, Cleveland Clinic Foundation Cleveland USA Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2287888 Sun, 22 Mar 2009 06:04:55 +0100 2287888 http://www.medworm.com/index.php?rid=2287889&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1754364542732828%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00592-009-0106-7Authors David S. H. Bell, University of Alabama Medical School Southside Endocrinology 1020, 26th Street South, Room 204 Birmingham AL 35205 USA Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2287889 Fri, 20 Mar 2009 10:22:42 +0100 2287889 http://www.medworm.com/index.php?rid=2287891&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0901xr4281276710%2F Abstract  Diabetes has been associated with depression since Thomas Willis’ work in 1684 (Rubin and Peyrot in Diabetes Metab Rev 18:173–175, 2002). The aim of this study is to identify social and clinical factors independently associated with depression in individuals with type 1 diabetes. We carried out a descriptive transversal study with 110 type 1 diabetes patients, administered a questionnaire and obtained demographical and diabetes-related data (number of years from diagnosis, initial admission at diagnosis, glycated hemoglobin, number of complications, insulin dose, number of insulin injections per day, admission for ketoacidosis or hypoglycemia at diagnosis, and specific diabetes complications such as nephropathy, retinopathy, peripheral neuropathy, coronariopath... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2287891 Fri, 20 Mar 2009 10:22:41 +0100 2287891 http://www.medworm.com/index.php?rid=2287890&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8w770273l8821220%2F In conclusion, all non-hyperglycaemic 24–28-week pregnant women should be tested for GDM, although particular attention must be paid to MG women with risk factors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0107-6Authors Antonio Desmond McCarthy, Universidad Nacional de La Plata Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas La Plata ArgentinaRenata Curciarello, Universidad Nacional de La Plata Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas La Plata ArgentinaNicolás Castiglione, Universidad Nacional de La Plata Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas La Plata ArgentinaMarina Fernández Tayeldín, Universidad Nacional de La Plata Cátedra de Bioquímica Patológica, Facultad de Ciencias... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2287890 Fri, 20 Mar 2009 10:22:41 +0100 2287890 http://www.medworm.com/index.php?rid=2277114&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg6326n2510207881%2F In conclusion, insulin secretagogues are associated with increased failure rate in comparison with metformin. This difference could be due to detrimental effect of secretagogues, rather than to a beneficial action of metformin. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0104-9Authors Laura Pala, University of Florence and Azienda Ospedaliera Careggi Section of Endocrinology, Department of Clinical Pathophysiology Florence ItalyMatteo Monami, University of Florence and Azienda Ospedaliera Careggi Unit of Geriatric Medicine, Department of Cardiovascular Medicine Florence ItalyCaterina Lamanna, University of Florence and Azienda Ospedaliera Careggi Unit of Geriatric Medicine, Department of Cardiovascular Medicine Florence ItalyBarbara Cresci, University... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2277114 Tue, 17 Mar 2009 06:52:26 +0100 2277114 http://www.medworm.com/index.php?rid=2263498&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl11334n02831j074%2F Abstract  Diastolic dysfunction is associated with a high rate of morbidity and mortality and has a high prevalence in patients with diabetes. Aim of the study was to investigate the prevalence of diastolic dysfunction in patients with newly detected glucose metabolism disorder (GMD) submitted for coronary angiography. Oral glucose tolerance test, echocardiography, and tissue Doppler imaging were performed in patients referred to coronary angiography. Prevalence of diastolic dysfunction was 97, 88, and 74% in the known diabetes, newly detected diabetes, and new diagnosed impaired glucose toleranc group, respectively. This is higher than previously reported. Severity of diastolic dysfunction was associated with higher 2-h plasma glucose levels and with new diagnosed diabetes... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2263498 Wed, 11 Mar 2009 11:25:30 +0100 2263498 http://www.medworm.com/index.php?rid=2251727&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp8224l1w45q34rj4%2F Abstract  The aim of this study is to assess whether intellectual ability in young adult men predicts the development of type 2 diabetes in later life. 641 men participating in the Helsinki Birth Cohort Study were administered a 2-h (75 g) oral glucose tolerance test at a mean age of 61 years. Intellectual ability was assessed during compulsory military service at a mean age of 20 years. Associations were explored using linear and logistic regression models. Intellectual ability in young adulthood did not predict glucose tolerance at age 61 years. However, educational attainment was associated with the prevalence of type 2 diabetes, independently of early intellectual ability. Men with the highest educational attainment were less likely to have type 2 dia... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2251727 Sat, 07 Mar 2009 11:01:34 +0100 2251727 http://www.medworm.com/index.php?rid=2213869&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu75868t84n8231n4%2F Abstract  ASP4000 ((2S)-1-{[(1R,3S,4S,6R)-6-hydroxy-2-azabicyclo[2.2.1]hept-3-yl]carbonyl}-2-pyrrolidinecarbonitrile hydrochloride) is a novel, potent and selective dipeptidyl peptidase 4 (DPP IV, EC 3.4.14.5) inhibitor (Keiko Tanaka-Amino et al. in Eur J pharmacol 59:444–449, 2008). The aim of the present study was to characterize the kinetic profile of and identify the long duration effect of the antihyperglycemic activity of ASP4000. ASP4000 was found to inhibit human recombinant DPP4 activity with a K i of 1.05 nM, a k on value of 22.3 × 105 M−1 s−1, and a k off of 2.35 × 10−3 M−1 s−1, with higher affinity than that of vildagliptin. The kinetic studies indicate that both the formation and dissociation of ASP400... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2213869 Tue, 24 Feb 2009 09:29:39 +0100 2213869 http://www.medworm.com/index.php?rid=2213872&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj76535764582p818%2F In conclusion BMI was positively correlated with WBCC in young adolescent females and males. Thus, BMI is the most important component of MetS in this age group. In addition, TG levels in males and FPG in females were significantly related to WBCC. These findings could be regarded an early indication for the future development of full-blown MetS or cardiovascular diseases. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0101-zAuthors Chung-Ze Wu, Shuang Ho Hospital, Taipei Medical University Division of Endocrinology and Metabolism, Department of Internal Medicine Taipei Taiwan, ROCFone-Ching Hsiao, Tri-Service General Hospital Division of Endocrinology and Metabolism, Department of Internal Medicine Taipei Taiwan, ROCJuinn-Diann Lin, Wan Fang Hospital, T... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2213872 Tue, 24 Feb 2009 09:29:38 +0100 2213872 http://www.medworm.com/index.php?rid=2213871&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F31817l7154478605%2F This study investigates the geospatial association between average daily ultraviolet B (UVB) irradiance and T1DM across the province of Newfoundland (NL), Canada. NL has one of the highest documented incidences of T1DM worldwide. A complete list of patients diagnosed (1987–2005) with T1DM in the province of Newfoundland and Labrador (NL) was constructed using multiple sources. All places of habitation at diagnosis were ascertained. Ecological analysis using Bayesian estimation was performed employing both NASA UVB data and latitude. Correlation of T1DM to both UVB irradiation and latitude was measured. A statistically significant correlation of erythemal UVB irradiance was observed (−0.0284: 95% CI −0.0542 to −0.0096). A more significant correlation of T1DM was observed with... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2213871 Tue, 24 Feb 2009 09:29:38 +0100 2213871 http://www.medworm.com/index.php?rid=2213870&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb5111178j6752853%2F In this study, we investigated the effect of retinal overexpression of human Ang-2 (mOpsinhAng2 mouse) on vascular morphology in non-diabetic and streptozotozin-induced diabetic animals. Pericyte (PC) coverage and acellular capillary (AC) formation were quantitated in retinal digest preparations after 3 and 6 months of diabetes duration. The degree of retinopathy in non-diabetic mOpsinhAng2 mice at 3 months (−21% PC, +49% AC) was comparable to age-matched diabetic wild type mice. Diabetic mOpsinhAng2 mice exhibited significantly worse vascular pathology than wild type counterparts at 6 months. Quantitative PCR revealed that human Ang-2 mRNA was highly overexpressed in retinas of transgenic mice. Our data demonstrate that overexpression of Ang-2 in the retina enhances... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2213870 Tue, 24 Feb 2009 09:29:38 +0100 2213870 http://www.medworm.com/index.php?rid=2189477&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr55176187t101964%2F Abstract  The status of inflammation may affect the collateral development in patients with diabetes mellitus (DM). Monocytes were found to have an important role in collateral growth in animal studies. We aimed to investigate the possible association of circulating monocyte count with collateral development in patients with DM and severe coronary artery disease (CAD). We enrolled 134 consecutive patients with DM who had ≥95 stenosis in at least one major coronary artery and investigated the relationship between circulating monocyte count and collateral growth. When we analyzed the coronary angiograms of eligible patients, we found that 64 of them had good collateral growth and 70 had poor collateral growth according to the Cohen–Rentrop method. The monocyte count was s... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2189477 Sat, 14 Feb 2009 07:52:12 +0100 2189477 http://www.medworm.com/index.php?rid=2189478&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1l51842762r76632%2F Abstract  The purpose of this study was to compare bioelectrical impedance analysis (BIA) to hydrostatic weighing (HW) in male weight lifters and body builders. Twenty-two male body builders and weight lifters, 23 ± 3 years of age (mean ± SD), were studied to determine the efficacy of BIA to HW in this population. Subjects were measured on two separate occasions, 6 weeks apart, for test–retest reliability purposes. Participants recorded 3-day dietary intakes and average work-out times and regimens between the two testing periods. Subjects were, on average, 75 ± 8 kg of body weight and 175 ± 7 cm tall. Validation results were as follows: constant error for HW–BIA = 0.128 ± 3.7%, r for HW ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2189478 Sat, 14 Feb 2009 07:52:10 +0100 2189478 http://www.medworm.com/index.php?rid=2165591&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3473237387644j48%2F In conclusions, our results did not identify an increased CAD risk with rosiglitazone in clinical practice. However, the results do reinforce a possible increased risk of adverse events in DM2 patients prescribed sulfonylureas. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0090-3Authors Kevin M. Pantalone, Cleveland Clinic Foundation Department of Internal Medicine 9500 Euclid Avenue NA10 Cleveland OH 44195 USAMichael W. Kattan, Cleveland Clinic Foundation Department of Quantitative Health Sciences Cleveland OH 44195 USAChanghong Yu, Cleveland Clinic Foundation Department of Quantitative Health Sciences Cleveland OH 44195 USABrian J. Wells, Cleveland Clinic Foundation Department of Quantitative Health Sciences Cleveland OH 44195 USASusana Arrigain, Clev... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2165591 Thu, 05 Feb 2009 07:46:09 +0100 2165591 http://www.medworm.com/index.php?rid=2151815&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F51r131nk584p5762%2F Abstract  The aim of this study was to estimate the present Polish incidence rate of diabetes mellitus type 1 in children aged 0–14. The research was conducted between 1989 and 2005 among the children of Upper Silesia region (Poland), being the part of the EURODIAB program, according to all criteria of this project. During this period, 1,385 new cases (720 boys) of diabetes mellitus type 1 were recognized. The analysis of the standardized incidence rates performed after dividing into shorter periods (1989–1994, 1995–1999, 2000–2005) showed a sharp increase from 5.80/105/year through 9.54/105/year to 15.26/105/year, respectively, in the periods. Analysis of age subgroups showed the greatest increase in the incidence rate among the younger children: 3.59 times for chil... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2151815 Sat, 31 Jan 2009 07:35:38 +0100 2151815 http://www.medworm.com/index.php?rid=2148753&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe4374661k758v5l5%2F Abstract  A cross-sectional descriptive study was done on patients recently entered into the National Diabetes Registry in Eritrea where the prevalence was estimated to be 2.2% based on patient information in 2004. Of the 627 patients with diabetes, two thirds were type 2. Although type 1 had poorer control (42.9%) than type 2 (29.9%), some of the risk factors such as cholesterol (43.4 vs. 28.2%), triglyceride (23.4 vs. 12.8%), hypertension (55.2 vs. 12.7%) as well as BMI and waist/hip ratio were higher in type 2 than type 1. More than one-third (41.2%) of patients with type 2 compared to type 1 (19.5%) had complications, the commonest being retinopathy (33%) followed by foot ulcers (14%) and neuropathy (4%). Many of the diabetic patients demonstrated the presence of the me... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2148753 Fri, 30 Jan 2009 08:33:20 +0100 2148753 http://www.medworm.com/index.php?rid=2148752&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnk823473254gv524%2F Abstract  To explore the number and distribution of microaneurysms (MA) in the macula of type 2 diabetics in Kinmen, Taiwan and associated risks for early diabetic retinopathy (DR). A baseline mass screening extracts 971 type 2 diabetics between 1991 and 1993 and follow-up eye screening at 1999 was then done. Number of MA was counted and associated systemic factors collected from a centered 45° color fundus photograph of dilated eyes of type 2 diabetics (Topcon-NW5). Thirty-three (6.2%, n = 527) had MA retinopathy. Those with one eye involved (n = 26) had two mean MA; those with bilateral involvement (n = 7) had four mean per eye. Most MA were located temporally (mean MA = 0.79), then superiorly (mean = 0.58), inferiorly (mean... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2148752 Fri, 30 Jan 2009 08:33:20 +0100 2148752 http://www.medworm.com/index.php?rid=2146164&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvn3763wq5n207355%2F Abstract  Low-grade inflammation is closely involved in the pathogenesis of type 2 diabetes and associated micro- and macrovascular complications. The nitric oxide (NO) precursor l-arginine, is relevant to diverse pathological conditions including type 2 diabetes and its complications. High sensitive-CRP (hs-CRP), neopterin and arginine levels were measured in 46 normoalbuminuric, 45 microalbuminuric type 2 diabetics and in 32 healthy controls in order to assess the relationship between markers of inflammation and l-arginine. Hs-CRP concentrations were higher in microalbuminuric diabetic patients compared to normoalbuminuric patients and controls. Diabetics had higher serum and urine neopterin levels than controls. Urine neopterin and l-arginine levels differed significantly ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2146164 Thu, 29 Jan 2009 08:16:00 +0100 2146164 http://www.medworm.com/index.php?rid=2146165&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl146515132656121%2F Abstract  Several association studies of type 2 diabetes mellitus (T2DM) and adiponectin gene polymorphisms have been reported with conflicting results. Our aim was to search for the association of three polymorphisms (−11.391G>A, +45T>G, and +276G>T) in the adiponectin gene with T2DM and prediabetic quantitative traits in Polish Caucasians. The study groups comprised 495 unrelated T2DM cases and 435 controls. We compared the distribution of genotypes between study groups. In addition, genotype-quantitative trait analyses were also done in the controls. The study subjects were genotyped using the restriction fragment length polymorphism technique. The frequencies of the minor alleles were as follows: 10.6 versus 8.2% for −11.391G>A (p = 0.0722), 7.0... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2146165 Thu, 29 Jan 2009 08:15:56 +0100 2146165 http://www.medworm.com/index.php?rid=2146166&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc7h1022257647075%2F Abstract  The purpose of this study is to evaluate efficacy and safety of nateglinide tablet administration in comparison with those of repaglinide tablet as control on treating type 2 diabetes mellitus in China. Pooled-analysis with analysis of covariance (ANCOVA) method was applied to assess the efficacy and safety based on original data collected from four independent randomized clinical trials with similar research protocols. However meta-analysis was applied based on the outcomes of the four studies. The results by meta-analysis were comparable to those obtained by pooled-analysis. The means of HbA1c, and fasting blood glucose in both the nateglinide and repaglinide groups were reduced significantly after 12 weeks duration but no statistical differences in reductio... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2146166 Thu, 29 Jan 2009 08:15:53 +0100 2146166 http://www.medworm.com/index.php?rid=2103224&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxu9w1275410gu8mm%2F Abstract  Type 2 diabetes is becoming epidemic. The personal and social burden imposed by diabetes will increase in the close future as its prevalence is expected to double in the next 15–20 years. Type 2 diabetes is caused by the combination of resistance to insulin action and inadequate insulin secretion. Despite the role of profound changes in individual environmental exposure is incontrovertible, several findings clearly indicate that type 2 diabetes and insulin resistance are also heritable. Among the several inhibitors of insulin signalling, which have been recently proposed as determinants of insulin resistance, is TRIB3, a mammalian tribbles homolog which affects insulin signalling at the level of Akt-2, a key modulator of insulin action in target cells. We h... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2103224 Tue, 13 Jan 2009 07:52:10 +0100 2103224 http://www.medworm.com/index.php?rid=2103225&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn2j53hn724541872%2F Abstract  We measured plasma concentrations of asymmetric dimethylarginine (ADMA), endothelin-1 (ET-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and E-selectin in 56 patients with gestational diabetes (GDM), 68 pregnant women with normal glucose tolerance (NGT) and 36 healthy non-pregnant women. ADMA concentrations were markedly lower in NGT [0.48 (0.42–0.55) μmol/l] than in GDM subjects [0.50 (0.43–0.67) μmol/l] and healthy controls [0.57 (0.46–0.72) μmol/l, P = 0.005]. ET-1 levels were comparable between GDM [0.76 (0.58–0.90) pg/ml] and NGT women [0.75 (0.63–0.92) pg/ml] and significantly higher than in the non-pregnant subjects [0.62 (0.52–0.72) pg/ml, P = 0.007 and P = 0.005, respectively]. There were no differences ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2103225 Tue, 13 Jan 2009 07:52:06 +0100 2103225 http://www.medworm.com/index.php?rid=2063883&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff8140031861t6r14%2F In conclusion, impairment of NO-mediated relaxations in diabetes may be related to hyperglycemia. The alterations caused by elevated glucose are not due to a hyperosmotic effect because the same concentration of sucrose had no effect on the relaxations. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0086-zAuthors T. Utkan, Kocaeli University Medical School Department of Pharmacology and Experimental Medical Research Center, Faculty of Medicine Kocaeli TurkeyF. Yildiz, Kocaeli University Medical School Department of Pharmacology and Experimental Medical Research Center, Faculty of Medicine Kocaeli TurkeyN. Z. Utkan, Kocaeli University Medical School Department of General Surgery Kocaeli TurkeyN. Gacar, Kocaeli University Medical School Department of Pharm... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2063883 Wed, 24 Dec 2008 06:51:07 +0100 2063883 http://www.medworm.com/index.php?rid=2063884&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx5t18x55026883v0%2F Abstract  Diabetic neuropathy is a significant complication of chronic diabetes. We wished to discover whether we were successfully identifying patients who had developed neuropathic problems. Specifically, Diabetologists are traditionally poor at asking about erectile dysfunction (ED) and patients themselves are not always forthcoming as it an embarrassing medical problem. We targeted all patients attending diabetes review clinics over a 4-month period in two hospitals and asked them to complete an anonymous, self-reported questionnaire after their consultation with the diabetologist or diabetes specialist nurse. Whilst most aspects of diabetic neuropathy are routinely screened for in the diabetes clinic we found that the neuropathic symptoms of both ED and gastroparesis w... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2063884 Wed, 24 Dec 2008 06:51:02 +0100 2063884 http://www.medworm.com/index.php?rid=2063885&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn812217k26324h42%2F Abstract  The aim of our study was to evaluate the frequency of hypoglycaemia unawareness and the continuous glucose profile in a group of subjects with Type 1 diabetes (T1D) with repeated non-severe/severe hypoglycaemia. Twenty patients (aged 35.2 ± 7.6 years, duration of disease 16.4 ± 6.4 years) were included. Hypoglycaemia awareness was evaluated using questionnaires and after an acute-induced hypoglycaemia. Glucose profile was studied using 72-h continuous glucose monitoring (CGM). All subjects were classified as having hypoglycaemia unawareness by questionnaires. Four patients displayed a “normal” signs/symptoms response to hypoglycaemia. The CGM revealed 18% of the measurements <70 mg/dl and this percentage was correlated wi... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2063885 Wed, 24 Dec 2008 06:50:58 +0100 2063885 http://www.medworm.com/index.php?rid=2063886&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe524800jnmx06565%2F Abstract  The purpose of this study was to determine if NO blood concentrations increased acutely following an 8-week course of pulsed infrared light therapy (PILT) which could be linked to an improvement in peripheral protective sensation (PPS) in patients who have profound chronic diabetic peripheral neuropathy. A total of 22 subjects with the diagnosis of type 1 (N = 2) or type 2 (N = 20) diabetes participated in the study. PILT was administered to one foot chosen at random with the other foot serving as a within-subject control (no treatment). Patients underwent 24 treatments (3 times/week, for 8 weeks) for 30 min per treatment. Venous blood samples were taken during the last 5 min of treatment from veins in the dorsum of the control and... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2063886 Wed, 24 Dec 2008 06:50:53 +0100 2063886 http://www.medworm.com/index.php?rid=2063887&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F61842856020v0556%2F Abstract  We aimed at updating the prevalence of impaired fasting glucose (IFG) and of undiagnosed (UD) and diagnosed diabetes (DD) among the Sardinian population. The survey was carried out from 2002 to 2005 on 4.737 subjects aged 20–80+ years. IFG was diagnosed when blood glucose was 110–125 mg/dl; UD when it was ≥126 mg/dl in the absence of personal history of diabetes; DD when personal history was positive, irrespective of blood glucose value. Prevalence rates (%) were adjusted for age by direct method to the Italian 2001 population. IFG was diagnosed in 11% of the sample (9.88% in females and 12.24% in males); UD was found in 5.65% (5.20 and 6.15%, females and males, respectively), DD in 8.72% (6.74 and 10.05%); and total diabetes (TD), i.e. the su... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2063887 Wed, 24 Dec 2008 06:50:49 +0100 2063887 http://www.medworm.com/index.php?rid=2030827&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F23h055h1nx18731k%2F The objective of the present study was to investigate the impact of these SNPs on T2DM intermediate phenotypes in order to clarify the physiological mechanisms through which they exert their effects on disease etiology. We analysed 23 SNPs in 9 T2DM genes (CDKAL1, CDKN2B, HHEX/IDE, IGF2BP2, KCNJ11, SLC30A8, TCF2, TCF7L2 and WFS1) in a maximum of 712 men and women from the Quebec Family Study. The participants underwent a 75 g oral glucose tolerance test (OGTT) and were measured for glucose, insulin and C-peptide levels. Indices of insulin sensitivity and insulin secretion were derived from fasting and OGTT measurements. We confirmed the significant associations of variants in CDKAL1, CDKN2B, HHEX/IDE, KCNJ11 and TCF7L2 with insulin secretion and also found associations of some of ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2030827 Thu, 11 Dec 2008 11:59:22 +0100 2030827 http://www.medworm.com/index.php?rid=2030826&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj167856583843214%2F This study was aimed at the assessment of incidence of malignancies in type 2 diabetic patients treated with different sulphonylureas. A matched case–control study was performed. Cases were 195 diabetic patients aged 69.0 ± 9.2 years who had an incident malignancy. Controls were 195 diabetic patients, unaffected by cancer, who were matched with the corresponding case for age, sex, duration of diabetes, BMI, HbA1c, comorbidity, smoking and alcohol abuse. Exposure to hypoglycaemic drugs during the 10 years preceding the event (or matching index date) was assessed. After adjusting for concomitant therapies, exposure to metformin and gliclazide for more than 36 months was associated with a significant reduction in the risk of cancer (adj. ORs with 95% CI: 0.28 ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2030826 Thu, 11 Dec 2008 11:59:22 +0100 2030826 http://www.medworm.com/index.php?rid=2009313&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F90111w32t7842u32%2F Abstract  Diabetes mellitus is commonly associated with both microvascular and macrovascular complications (coronary artery disease, cerebrovascular events, severe peripheral vascular disease, nephropathy and retinopathy). There is wide evidence demonstrating that platelet degranulation and synthesis of TxA2 are increased in diabetic patients. For this reason, many studies on anti-platelet therapy have been made to reduce thrombotic complication of diabetes mellitus. Some diabetic patients, although treated with ASA, have a high prevalence of recurrent thrombotic events, which may presumably be due to an “ASA resistance”. Nevertheless, this drug remains the one with the greatest benefit. To optimize its function, we should try to understand the causes of “aspirin resi... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=2009313 Tue, 02 Dec 2008 07:26:40 +0100 2009313 http://www.medworm.com/index.php?rid=1983178&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa531q2h83033t13v%2F Abstract  Islet transplantation is a promising therapeutic option for type 1 diabetes, and actively performed in the clinic as well as in the animal experiments. For the rodent experiments, islet transplantation into kidney subcapsule is widely used to assess islet quality, however, it is often difficult to do using a polyethylene tubing and fine needle because of inherent dead volume of needle and stickiness of the tubing to islets. This problem makes it difficult to interpret the physiological response to different islet doses. Here, we developed a simple fibrin gel carrier system for islet transplantation into kidney subcapsule and utilized it to determine the marginal islet mass sufficient for correction of hyperglycemia in diabetic nude mice. Content Type Journal Art... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1983178 Sun, 23 Nov 2008 06:48:59 +0100 1983178 http://www.medworm.com/index.php?rid=1983177&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj4xl521221t5l07l%2F Abstract  This randomised, open-label, two-way cross-over study compared the coefficient of variance (CV) of fasting and postprandial blood glucose (FBG and PPBG) with insulin glargine (glargine) versus neutral protamine Hagedorn (NPH) insulin treatment in patients with Type 2 diabetes (T2DM). Patients (N = 20) on oral antidiabetic drugs (OADs) were treated with NPH (at bedtime) or glargine (at dinnertime) for 12 weeks of each cross-over treatment period; OADs were continued. The FBG CV was calculated from self-monitored BG values and PPBG using venous blood samples, or continuous glucose monitoring system (CGMS). Both insulins provided similar improvements in glycaemic control; however, PPBG was significantly lower after a standard meal test (performed at 13:... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1983177 Sun, 23 Nov 2008 06:48:59 +0100 1983177 http://www.medworm.com/index.php?rid=1983179&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe315087p5128848t%2F Abstract  Only 49% of the patients with T2D in Sweden that medicate with oral antihyperglycaemic drugs (AHGD) had good blood glucose control (HbA1C < 6.0%). The reason can be low medication adherence. The aim of this study was, therefore, to determine the adherence to different oral AHGD. Included were all patients in Sweden, older than 40 years and having at least two expenditures of AHGD between 1 December 2005 and 30 November 2006. After exclusions of inpatients and patients with unspecified daily dosage 171,220 patients (57% men) remained. Medication possession ratio (MPR) was used for estimating adherence and patients were regarded adherent if MPR ≥80%. The overall refill adherence average 90%, with mean MPR (SD) = 107% (30). Eighty-five pe... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1983179 Fri, 21 Nov 2008 07:11:21 +0100 1983179 http://www.medworm.com/index.php?rid=1983180&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6p5m86j2221250q4%2F Abstract  The aim of this study was to characterize the abnormalities in glucose homeostasis in intensive care unit patients following an acute coronary event. The study population included all non-diabetic patients ages 20–80 years that were admitted to a coronary intensive unit. Glucose, insulin and C-peptide levels during an oral glucose tolerance test (OGTT) were measured during the acute admission. From January to September 2003, 277 patients were admitted to the coronary unit. Of these, 127 patients underwent an OGTT. Of these, only 29 patients (23%) exhibited normal glucose metabolism. The remainder had type 2 diabetes (32%), impaired glucose tolerance (37%) or isolated impaired fasting glucose (8%, 100–125 mg/dl). Based on homeostasis model assessment ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1983180 Fri, 21 Nov 2008 07:11:20 +0100 1983180 http://www.medworm.com/index.php?rid=1944509&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F45680r17534352wl%2F Abstract  Metabolic syndrome (MS) has been associated with microalbuminuria and kidney disease. In the present cohort study, different methods for the estimation of glomerular filtration rate (GFR) on the basis of serum creatinine were compared with respect to their association with MS and their predictive value for incident diabetes mellitus. The present analysis was performed on the cohort of subjects enrolled in the FIBAR study, a screening program for diabetes. GFR was estimated (eGFR) using three different methods: Cockroft-Gault (CG) formula, using actual body weight (CAW), CG formula using ideal body weight (CIW), and Modification of Diet in Renal Disease formula (M). The study was performed on 2,694 nondiabetic subjects, without history of renal insufficiencey or se... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1944509 Fri, 07 Nov 2008 08:13:14 +0100 1944509 http://www.medworm.com/index.php?rid=1944510&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkrt44726378k5ph2%2F Abstract  The aim of this prospective study was to evaluate the morbidity of invasive urodynamic study (UDS) in type 2 diabetic patients. Study was conducted on 94 diabetic (59.4 ± 0.8 years) and 110 non-diabetic (58.1 ± 0.9 years) patients who had lower urinary tract symptoms. All patients underwent pressure-flow study. The major complication rate after UDS, including urinary tract infection, fever, urinary retention and gross hematuria, was 11.8% for non-diabetics and 22.3% for diabetics (p = 0.044). No significant differences were found between diabetics and non-diabetics according to gender with respect to dysuria, hematuria and pain (p > 0.05). Existence of pyuria before UDS was significantly higher in diabetic women... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1944510 Fri, 07 Nov 2008 08:13:13 +0100 1944510 http://www.medworm.com/index.php?rid=1887670&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F17737811968u5701%2F Abstract  The metabolic syndrome consists of a constellation of clinical and biochemical risk factors that cluster together and heighten the risk for atherogenesis, cardiovascular diseases, and diabetes. Established risk cardiovascular factors like hypertension, atherogenic dyslipidaemia, and glucose intolerance occur in the setting of insulin resistance and central adiposity, with genetic and environmental influences modulating the ultimate risk. Chronic insults to the endothelium take its toll in the form of silent as well as clinically evident cardiovascular events. The cellular and vascular accompaniments have shed some light into the underlying pathophysiology. Heightened, low-grade inflammatory processes as well as a continuum of vascular insults ranging from early en... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1887670 Fri, 17 Oct 2008 08:50:26 +0100 1887670 http://www.medworm.com/index.php?rid=1878035&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxrk31t5154v0j681%2F In conclusion, the increase in the SSAO activity and NO x levels observed in type 2 diabetic patients could be parameters to take in account and play relevant role in diabetes development. SSAO and NO x are suggested as markers for prognostic of diabetes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0070-7Authors Sandra Fernanda Nunes, University of Coimbra Laboratory of Pharmacology, Faculty of Pharmacy 3000-175 Coimbra PortugalIsabel Vitoria Figueiredo, University of Coimbra Laboratory of Pharmacology, Faculty of Pharmacy 3000-175 Coimbra PortugalPaulo João Soares, São José Laboratory Coimbra PortugalNuria Espriu Costa, University of Coimbra Laboratory of Pharmacology, Faculty of Pharmacy 3000-175 Coimbra PortugalMaria Celeste Lopes, University... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1878035 Tue, 14 Oct 2008 11:20:33 +0100 1878035 http://www.medworm.com/index.php?rid=1878034&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff470371273716j55%2F Abstract  To investigate the relationship of micro-albuminuria with C-reactive protein (CRP) and hyperuricemia in Chinese patients with type 2 diabetes. All patients with type 2 diabetes, 40 years old and over were recruited consecutively from diabetic clinics at a medical center. Serum lipid, creatinine, uric acid, CRP, HbA1C and urinary albumin concentration were measured. A total of 515 patients, aged 60.3 ± 10.7 years were recruited and the number (rate) of micro- and macro-albuminuria were 109 (21.2%) and 55 (10.7%). The prevalence of micro-albuminuria for the quartiles of CRP levels demonstrated a meaningful trend of increases between groups from 17.4, 21.1, 30.3, and 31.2% (P trend = 0.002). Besides, the median CRP concentrations was sign... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1878034 Tue, 14 Oct 2008 11:20:33 +0100 1878034 http://www.medworm.com/index.php?rid=1869765&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4120gw279365464t%2F In conclusion, the present study revealed that vitamin D deficiency was higher in T1DM children compared to non-diabetic. Moreover, vitamin D deficiency was common in Qatari young population. Vitamin D intake was very poor in children and it shows that supplementing infants with vitamin D might be a safe and effective strategy for reducing the risk of T1DM. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0071-6Authors Abdulbari Bener, Hamad Medical Corporation, Weill Cornell Medical College Qatar Department of Medical Statistics and Epidemiology, Hamad General Hospital PO Box 3050 Doha QatarAmer Alsaied, Weill Cornell Medical College Qatar Medical Education Doha QatarMariam Al-Ali, Hamad Medical Corporation Department of Pediatrics, Hamad General Hospita... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1869765 Fri, 10 Oct 2008 08:02:43 +0100 1869765 http://www.medworm.com/index.php?rid=1867067&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F681252m847427x22%2F In conclusion, the 6-month-old GK diabetic rats developed osteopenia with an increased risk of fracture owing to the decreased bone formation, and might be a useful model for unraveling the effects of diabetes on bones independent of obesity frequently seen in the type 2 diabetic patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0068-1Authors Liping Zhang, Shandong University Department of Endocrinology, Qilu Hospital 44#, Wenhua Xi Road 250012 Jinan People’s Republic of ChinaYaping Liu, Shandong Institute of Endocrine and Metabolic Diseases 89#, Jingshi Road 250062 Jinan Shandong Province People’s Republic of ChinaDong Wang, Shandong Institute of Endocrine and Metabolic Diseases 89#, Jingshi Road 250062 Jinan Shandong Province People’s Repu... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1867067 Thu, 09 Oct 2008 10:23:27 +0100 1867067 http://www.medworm.com/index.php?rid=1867066&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe56936j4561pq346%2F Abstract  A low educational level and a poor socioeconomic status could be associated with increased risk for chronic diseases. The aim of the study was to evaluate the relationship between the educational level and cardiometabolic risk in adult patients with type 1 diabetes (n = 437; age: 38.0 ± 10.4 years, duration of diabetes: 19.2 ± 11.1 years; x ± SD). Educational levels were classified as low [primary school, n = 56 (12.8%)], middle [high school, n = 251 (57.4%)] or high [university, n = 130 (29.7%)]. The prevalence rate of the metabolic syndrome proved to be higher in patients with low versus high educational levels (ATP-III criteria: 42.9 vs. 21.5%, P = 0.0006). Antihypertensiv... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1867066 Thu, 09 Oct 2008 10:23:27 +0100 1867066 http://www.medworm.com/index.php?rid=1864394&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd7g8501952747271%2F Abstract  Insulin resistance (IR) and obesity may be associated with impaired response to physical exercise. We aimed at assessing physical capacity in obese children with biopsy proven non-alcoholic fatty liver disease (NAFLD) as compared to normal weight and obese children without fatty liver disease. All male subjects, 20 NAFLD and 31 control individuals (20 obese, without NAFLD and 11 normal weight children) took part in the study. We evaluated changes in cardiovascular parameters during a bicycle–ergometer exercise test (James’ test). Duration, power of exercise, heart rate (HR), blood pressure (BP), pulse pressure, cardiac output (ICO) and total peripheral vascular resistance indexed for height (ITPVR) were recorded at rest (r) and peak (p) exercise. The homeostati... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1864394 Wed, 08 Oct 2008 10:50:00 +0100 1864394 http://www.medworm.com/index.php?rid=1864393&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm71157195jg4072n%2F In conclusion, short-term PF-PPS therapy was effective on cardiovascular autonomic function and vibration perception, whereas it failed to reduce albuminuria within normal range in type 2 diabetic patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0064-5Authors Boglárka Laczy, University of Pecs Second Department of Medicine and Nephrological Center, Faculty of Medicine Pacsirta u. 1. 7624 Pecs HungaryJudit Cseh, University of Pecs Second Department of Medicine and Nephrological Center, Faculty of Medicine Pacsirta u. 1. 7624 Pecs HungaryMárton Mohás, University of Pecs Second Department of Medicine and Nephrological Center, Faculty of Medicine Pacsirta u. 1. 7624 Pecs HungaryLajos Markó, University of Pecs Second Department of Medicine and Nep... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1864393 Wed, 08 Oct 2008 10:50:00 +0100 1864393 http://www.medworm.com/index.php?rid=1864395&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc271u22210286666%2F In conclusion, serum GA levels were significantly lower in smokers than in nonsmokers. Smoking was identified as a significant negative explanatory variable for serum GA levels. These findings suggest that the inflammation-induced acceleration of albumin metabolism may be involved in the mechanism by which smoking is associated with serum GA levels. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0072-5Authors Masafumi Koga, Kinki Central Hospital Department of Internal Medicine Kuruma-zuka 3-1 Itami Hyogo 664-8533 JapanHiroshi Saito, Kinki Central Hospital Department of Internal Medicine Kuruma-zuka 3-1 Itami Hyogo 664-8533 JapanMikio Mukai, Kinki Central Hospital Department of Internal Medicine Kuruma-zuka 3-1 Itami Hyogo 664-8533 JapanMichio Otsuki, O... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1864395 Wed, 08 Oct 2008 10:49:59 +0100 1864395 http://www.medworm.com/index.php?rid=1864396&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F437822022g7684r4%2F Abstract  Insulin resistance is a major feature of type 2 diabetes mellitus, obesity and nonalcoholic fatty liver disease (NAFLD). Several studies pointed out the possible role of increased leptin in NAFLD in humans. The aim of this study is to determine the effect of metformin on plasma leptin levels in obese patients with type 2 diabetes mellitus and NAFLD compared with lifestyle interventions. Thirty-four obese patients with newly diagnosed type 2 diabetes mellitus were prospectively followed for 6 months. All patients had ultrasonographic evidence of NAFLD at baseline. The patients were randomized into two groups: group 1 (n = 15) followed lifestyle changes only and group 2 (n = 19) received metformin (1,700 mg/day). At the end of treatment, ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1864396 Wed, 08 Oct 2008 10:49:58 +0100 1864396 http://www.medworm.com/index.php?rid=1849574&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx50r70g94067v247%2F In this study, we examined the association between baseline PON1 status and the development of cardiovascular disease (CVD) during 10 years of follow-up in 88 type 2 diabetic patients whose enzymatic activities, concentrations, and genetic polymorphisms of PON1 had been determined. A total of 20 CVD events were recorded during the follow-up period. Using Kaplan–Meier survival curves, we found a significantly increased incidence of CVD in patients with a lower concentration or paraoxonase activity of PON1 than each median value (log-rank 7.460; P < 0.01, and log-rank 4.187; P < 0.05, respectively). By Cox regression analysis, both concentration and paraoxonase activity were significantly associated with the development of CVD, even after correction for ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1849574 Thu, 02 Oct 2008 09:29:06 +0100 1849574 http://www.medworm.com/index.php?rid=1849575&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe8392753j410r124%2F In conclusion, GCT performed irrespective of the last meal timing is a patient-friendly approach and causes least disturbance in the pregnant woman’s routine activities. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0060-9Authors C. Anjalakshi, Institute of Obstetrics and Gynecology Chennai IndiaV. Balaji, Dr V Seshiah Diabetes Care and Research Institute 31A, Ormes Road, Kilpauk Chennai 600 010 Tamil Nadu IndiaMadhuri S. Balaji, Dr V Seshiah Diabetes Care and Research Institute 31A, Ormes Road, Kilpauk Chennai 600 010 Tamil Nadu IndiaS. Ashalata, Dr V Seshiah Diabetes Care and Research Institute 31A, Ormes Road, Kilpauk Chennai 600 010 Tamil Nadu IndiaSheela Suganthi, Dr V Seshiah Diabetes Care and Research Institute 31A, Ormes Road, Kilpauk Chennai 6... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1849575 Thu, 02 Oct 2008 09:29:05 +0100 1849575 http://www.medworm.com/index.php?rid=1842955&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu6x1j11848785770%2F Abstract  Aim of this prospective study is to evaluate the effect of repaglinide t.i.d. (three times a day) plus single-dose insulin glargine regimen in low-risk type 2 diabetic patients during Ramadan fasting. Participants had been taking the regimen for at least 3 months. Patients with a history of diabetic coma, severe hypoglycemic crisis or repeating attacks of hypoglycemia were excluded. Hypoglycemic unawareness, kidney or liver disease or HbA1c over 8% were also accepted as exclusion criteria. Eleven patients who insisted on this worship and eight non-fasting cases were involved. All were told to make home-glucose-monitorisation weekly and report any hypoglycemic event throughout Ramadan. Fasting blood glucose (FBG), post-prandial blood glucose (PBG) and fructosa... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1842955 Tue, 30 Sep 2008 09:20:37 +0100 1842955 http://www.medworm.com/index.php?rid=1839496&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqr321435ml35674k%2F Abstract  Inflammation is involved in the pathophysiologic process of atherosclerosis, a frequent complication of type 2 diabetes. The purpose of our study was to investigate the effect of pioglitazone on systemic inflammatory markers and activation of circulating monocytes in type 2 diabetic patients through the dosage of IL-6. Twenty-four metformin-treated patients, in good glycemic control, were randomized to add pioglitazone for 8 weeks or to continue their previous treatment. Blood samples were collected before and at the end of the study to evaluate: serum levels of high sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6 and leukocyte activation. IL-6 production of circulating monocytes after LPS stimulation was similar at baseline and showed a 54% reduc... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1839496 Sat, 27 Sep 2008 14:05:59 +0100 1839496 http://www.medworm.com/index.php?rid=1834222&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh4012j2t63728375%2F In conclusion, the CGM CV% may contribute to better describe the individual metabolic state and to understand the pathogenesis of endothelial dysfunction in non diabetic subjects with MS. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0061-8Authors Silvio Buscemi, Università di Palermo, Policlinico “P. Giaccone” Dipartimento di Medicina Interna, Malattie Cardiovascolari e NefroUrologiche, Facoltà di Medicina Via del Vespro, 129 90127 Palermo ItalySalvatore Verga, Università di Palermo, Policlinico “P. Giaccone” Dipartimento di Medicina Interna, Malattie Cardiovascolari e NefroUrologiche, Facoltà di Medicina Via del Vespro, 129 90127 Palermo ItalySantina Cottone, Università di Palermo, Policlinico “P. Giaccone” Dipartimento di Medicina In... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1834222 Fri, 26 Sep 2008 06:04:00 +0100 1834222 http://www.medworm.com/index.php?rid=1834221&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh57588400754v676%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s00592-008-0059-2Authors Pierre Lefèbvre, CHU Sart Tilman Division of Diabetes, Department of Medicine 4000 Liège 1 Belgium Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1834221 Fri, 26 Sep 2008 06:04:00 +0100 1834221 http://www.medworm.com/index.php?rid=1781327&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff4x3885h37237qhu%2F Abstract  Our aim was to study, at the same glycemic control, how treatment with either the insulin secretagogue repaglinide or exogenous insulin aspart affects endogenous insulin secretion, plasma insulin and IAPP (islet amyloid polypeptide) levels, GH-IGF (growth hormone-insulin-like growth factor) axis and plasma lipoprotein concentrations in patients with type 2 diabetes. Five patients, age 65.0 ± 4.1 years (mean ± SE), body weight 82.5 ± 5.0 kg, BMI (body mass index) 27.7 ± 1.5 kg/m2 were treated for 10 weeks with repaglinide or insulin aspart in a randomized, cross-over study. At the end of each treatment a 24-h metabolic profile was performed. Blood glucose, C-peptide, free human insulin, free total (human... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1781327 Tue, 09 Sep 2008 00:36:39 +0100 1781327 http://www.medworm.com/index.php?rid=1767356&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1864227686j5694x%2F This study in 1–18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0048-5Authors Sabina Resic-Lindehammer, University Hospital MAS, CRC/Lund University Department of Clinical Sciences, Unit of Diabetes and Celiac Disease Ent 72 Bldg 91 Floor 10 205 02 Malmö SwedenK. Larsson, Kristianstad Hospital Department of Pediatrics Kristianstad SwedenE. Örtqvist, Astrid Lindgren’s Hospital Department of Pediatrics Solna SwedenA. Carlsson, University Hospital, Lund University Department of Clinical Sciences, Unit of Pediatrics Malmö SwedenE. Cederwall, University Hospital MAS, CRC/Lund University Department of Clinical Sciences, Unit of Diabetes and Celiac... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1767356 Thu, 04 Sep 2008 08:09:48 +0100 1767356 http://www.medworm.com/index.php?rid=1762036&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm3m876328hj820v2%2F Abstract  Intensive insulin therapy aimed at achieving normoglycaemia is becoming increasingly accepted in the treatment of type 2 diabetes (T2DM) to reduce the risk of diabetes-related complications. Insulin therapy is increasingly combined with oral antidiabetic drugs (OADs) to moderate insulin dosage, reduce weight gain and confer cardiovascular protection. However, traditional insulins are associated with limitations that may act as barriers to initiation, and intensive use of insulin therapy. The advent of newer, longer-acting, basal insulin analogues, such as insulin glargine (glargine) and insulin detemir (detemir), offer improved pharmacokinetic and pharmacodynamic profiles compared with neutral protamine Hagedorn insulin (NPH). This potentially provides concomitant... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1762036 Wed, 03 Sep 2008 12:38:30 +0100 1762036 http://www.medworm.com/index.php?rid=1748952&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr67n60256027l054%2F Abstract  The purpose of this study was to assess the effects of PPAR-γ agonists (pioglitazone and rosiglitazone) on mediators of endothelial dysfunction and markers of angiogenesis in patients with type-2 diabetes. Pioglitazone group showed favorable reductions in serum total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and increase in HDL cholesterol as compared to rosiglitazone group, after 16 weeks of treatment and also with control group. There was significant reduction of CRP level in pioglitazone and rosiglitazone group. The level of serum TNF-α decreased significantly in pioglitazone and mildly decreased in rosiglitazone group. The level of VEGF, IL-8 and Angiogenin were increased in pioglitazone than rosiglitazone group. There were no signifi... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1748952 Sat, 30 Aug 2008 08:11:58 +0100 1748952 http://www.medworm.com/index.php?rid=1748951&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa05724m4379g1864%2F Abstract  The KCNJ11 and ABCC8 genes encode the components of the pancreatic ATP-sensitive potassium (KATP) channel, which regulates insulin secretion by β-cells and hence could be involved in the pathogenesis of type 2 diabetes (T2D). The KCNJ11 E23K and ABCC8 exon 31 variants have been studied in 127 Russian T2D patients and 117 controls using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. The KCNJ11 E23 variant and the ABCC8 exon 31 allele A were associated with higher risk of T2D [Odds ratio (OR) of 1.53 (P = 0.023) and 2.41 (P = 1.95 × 10−5)], respectively. Diabetic carriers of the ABCC8 G/G variant had reduced 2 h glucose compared to A/A + A/G (P = 0.031). The G/G gen... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1748951 Sat, 30 Aug 2008 08:11:58 +0100 1748951 http://www.medworm.com/index.php?rid=1748953&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9u037761614l7w56%2F Abstract  Ophthalmoplegia, despite being a rare entity in diabetes mellitus, is associated with great anxiety for the patients and often appears to be a serious problem from a diagnostic and therapeutic point of view. There have been few studies primarily concerned with the relative frequencies and clinical characteristics of oculomotor neuropathies in diabetic subjects. Those published have emanated largely from neurological and/or ophthalmological referral centres rather than metabolic departments. Objective of this study was to determine the incidence, the clinical characteristics and risk factors for developing ophthalmoplegia among persons with diabetes mellitus. We have performed a retrospective study of all diabetic patients with ophthalmoplegia who were seen in the ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1748953 Sat, 30 Aug 2008 08:11:57 +0100 1748953 http://www.medworm.com/index.php?rid=1703440&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F081456m45123p44v%2F Abstract  Diabetes is a major socio-economical burden with serious health consequences. The reactive oxygen species generated in this pathology alters the internal milieu of the cellular systems paving way to metabolic disorders. In the present investigation garlic’s dose-dependent protective action against streptozotocin (STZ)-induced oxidative stress in hepatic and intestinal tissues has been studied. Methanolic garlic extract scavenged the DPPH radical with an IC50 of 424 ± 4.4 μg/ml proving its efficient antioxidant property. Garlic administration at 250 and 500 mg/kg body wt. significantly normalized the blood glucose in the diabetic rats. Biochemical analysis revealed a pronounced oxidative stress in STZ-rats (G-II) consequent to hyperglycemia as seen by a signific... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1703440 Tue, 12 Aug 2008 07:34:30 +0100 1703440 http://www.medworm.com/index.php?rid=1698751&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F14g2001q14w0p85n%2F Abstract  Studies investigating the effect of leptin on bone mass were inconsistent and some related it to the effect of insulin. We intend in this cross-sectional study to investigate the effect of leptin on bone mass in type 1 diabetic patients. We recruited 42 patients with type 1 diabetes for which we determined weight, height, HbA1c, microalbuminuria, serum leptin, bone mineral content (BMC) and density (BMD), and body composition. The patients had an average age of 20.1 ± 0.6 years, an average body mass index (BMI) of 23.6 ± 0.5 kg/cm2 and an average duration of diabetes of 9.1 ± 1.0 years. The Z-score was not correlated with HbA1c or duration of the disease, and the average Z-score was not different in patients with micro... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1698751 Sat, 09 Aug 2008 12:42:56 +0100 1698751 http://www.medworm.com/index.php?rid=1693250&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6r8p1t2m1270hv67%2F This study confirms previous data suggesting that predialysis comorbid conditions are significantly associated with mortality in DM patients on dialysis and provides a prognostic model to help clinicians focus on various factors that may require attention before initiating this treatment. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0043-xAuthors J. M. Mauri, Josep Trueta Teaching Hospital Nephrology Department Girona SpainE. Vela, Catalan Health Service Travessera de les Corts, 131-159 08028 Barcelona SpainM. Clèries, Catalan Health Service Travessera de les Corts, 131-159 08028 Barcelona Spain Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1693250 Fri, 08 Aug 2008 07:04:33 +0100 1693250 http://www.medworm.com/index.php?rid=1690806&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5563037045118148%2F Abstract  Sleep disturbances may be associated with impaired glucose metabolism. The aim of this study was to evaluate sleep duration and quality in relation to glycemic control in patients with type 2 diabetes. In a cross-sectional study, sleep duration and quality were assessed in 47 middle-aged patients with type 2 diabetes treated with oral agents and without sleep disturbing complications and 23 healthy control subjects similar by age, sex, body mass index, occupation and schooling. Sleep was recorded by wrist-actigraphy for three consecutive days under free-living conditions. Univariate analysis showed lower sleep maintenance (P = 0.002) and sleep efficiency (P = 0.005), and higher fragmentation index (P < 0.0001), total activity score (... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1690806 Thu, 07 Aug 2008 10:06:14 +0100 1690806 http://www.medworm.com/index.php?rid=1687780&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F853q623l37526881%2F Abstract  The incretin system has been shown to stimulate insulin secretion in a glucose dependent manner and currently fosters considerable hope for the treatment of diabetes. Recently, we have shown that the dipeptidylpeptidase-4 (DPP4) gene, which is responsible for incretin inactivation, was overexpressed in omental adipose tissue of obese men with the metabolic syndrome, compared to men not characterized by this condition. Since the cardiovascular disease (CVD) risk profile shows substantial inter-individual variability in obesity, this study aimed at verifying whether DPP4 polymorphisms contribute to explain such a difference. In the first step of this multi-stage study, seven tagging SNPs were genotyped in a sample of 576 obese (BMI > 40 kg/m2) indivi... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1687780 Wed, 06 Aug 2008 05:52:23 +0100 1687780 http://www.medworm.com/index.php?rid=1650977&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx2n3u96227043588%2F This study suggests that the absence of complications in DM1 patients up to 5 years after onset of the disease may be associated with the oxidizing and reducing balance which need to be maintained in order to prevent or delay the onset of oxidative stress. The effective diabetic control involves evaluation of the oxidizing/antioxidant balance besides glycaemic control. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-008-0046-7Authors Janice Sepúlveda Reis, Santa Casa de Belo Horizonte Hospital Núcleo de Pesquisa e Pós-Graduação (NPPG) Av. Francisco Sales 1111, 9° andar ala D, Belo Horizonte 30250-221 Minas Gerais BrazilAdriana A. Bosco, Santa Casa de Belo Horizonte Hospital Núcleo de Pesquisa e Pós-Graduação (NPPG) Av. Francisco Sales 1111, 9�... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1650977 Wed, 23 Jul 2008 05:56:15 +0100 1650977 http://www.medworm.com/index.php?rid=1636542&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm38q033478336h37%2F Abstract  The purpose of this study is to identify the recent characteristics and the developments of therapeutic education in diabetes through an analysis of the international articles published from 2004 to 2007. Studies were selected from several databases: Medline, Embase, Eric, Cochrane central database, using the following keywords: diabetes, patient education, self management, programs. Two authors independently reviewed each study and selected the data using the same categories of analysis. Articles consistently related to patient education in diabetes (80 among 118) were included. The selected articles have been published in 43 scientific journals. The majority of them concern TPE for adult patients with type 2 diabetes. TPE is delivered in several structures and e... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1636542 Thu, 17 Jul 2008 05:59:52 +0100 1636542 http://www.medworm.com/index.php?rid=1604327&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm38516h275801061%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00592-008-0045-8Authors Keiichi Yamatani, Niigata Teishin Hospital Department of Internal Medicine 2-2-8 Yachiyo, Chuoku Niigata 950-8798 JapanYoichi Iwasaki, Tsubame Rosai Hospital Tsubame Japan Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1604327 Wed, 09 Jul 2008 06:00:09 +0100 1604327 http://www.medworm.com/index.php?rid=1549000&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F31t5138631719625%2F Abstract  Thiamine (vitamin B1) is an essential cofactor in most organisms and is required at several stages of anabolic and catabolic intermediary metabolism, such as intracellular glucose metabolism, and is also a modulator of neuronal and neuro-muscular transmission. Lack of thiamine or defects in its intracellular transport can cause a number of severe disorders. Thiamine acts as a coenzyme for transketolase (TK) and for the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes, enzymes which play a fundamental role for intracellular glucose metabolism. In particular, TK is able to shift excess fructose-6-phosphate and glycerhaldeyde-3-phosphate from glycolysis into the pentose-phosphate shunt, thus eliminating these potentially damaging metabolites from t... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1549000 Thu, 26 Jun 2008 06:31:13 +0100 1549000 http://www.medworm.com/index.php?rid=1468266&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn133h2488774g7j8%2F Abstract  To clarify the effect of early insulin therapy on nuclear factor κB (NFκB) pathway and inflammatory cytokine responses in the liver and skeletal muscle in type 2 diabetes. High-fat diet and low dose streptozotocin (STZ) induced diabetic rats were given NPH insulin or gliclazide for 3 weeks initiated at the 3rd day after STZ injection as early treatment and NPH for 3 weeks at 1 month as late treatment. Intraperitoneal glucose tolerance test (IPGTT) was performed at 3rd day after the end of treatment. Early interventions caused a decrease in glucose-insulin index in IPGTT, promoted glucose transporter 4 (Glut4) gene and protein expressions in muscle and reduced phosphoenolpyruvate carboxykinase (PEPCK) protein levels in the liver. There was an increase in inhibito... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1468266 Sat, 24 May 2008 07:20:38 +0100 1468266 http://www.medworm.com/index.php?rid=1468265&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx0tg7268522j0446%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00592-008-0036-9Authors GianFranco Ferraccioli, Catholic University of the Sacred Heart Department of Rheumatology, School of Medicine Via Moscati, 31 00168 Rome ItalyElisa Gremese, Catholic University of the Sacred Heart Department of Rheumatology, School of Medicine Via Moscati, 31 00168 Rome ItalyMaria De Santis, Catholic University of the Sacred Heart Department of Rheumatology, School of Medicine Via Moscati, 31 00168 Rome Italy Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1468265 Sat, 24 May 2008 07:20:38 +0100 1468265 http://www.medworm.com/index.php?rid=1466521&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F87pq698786026294%2F Abstract  Screening for glucose intolerance during pregnancy provides an opportunity to offer management to those women diagnosed with gestational diabetes mellitus. However, there is a need to diagnose gestational diabetes early to minimize exposure of the developing fetus to suboptimal conditions and prevent perinatal complications and their sequelae. The purpose of this study was to identify potential biomarkers for impending gestational diabetes that appear in the plasma before impaired glucose tolerance. Pregnant women were prospectively recruited to the study and blood was collected at the first antenatal visit and at the time of routine oral glucose tolerance test. Women diagnosed with gestational diabetes were matched with an equal number of normal pregnant (control... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1466521 Thu, 22 May 2008 05:56:12 +0100 1466521 http://www.medworm.com/index.php?rid=1466520&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg7174204m084q27g%2F Abstract  Impaired fasting glucose (IFG) like impaired glucose tolerance (IGT) has increased risk of progressing to diabetes mellitus (DM). The aim of the study was to evaluate prevalance of IGT and type 2 DM with oral glucose tolerance test (OGTT) in Turkish patients who had fasting glucose of 110 and 125 mg/dl. Hundred and forty-eight (67.3%) women and 72 (32.7%) men (30–65 years old with mean age of 51.3 ± 8.7 year) who had fasting glucose range 110–125 mg/dl were evaluated with OGTT. Seventy-two patients had IGT (32.8%), 74 (33.6%) patients had type 2 diabetes and 74 (33.6%) patients had normal glucose tolerance (NGT). Mean fasting glucose and insulin levels were higher in the IGT group than in the NGT group. Mean level of total cholesterol ... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1466520 Thu, 22 May 2008 05:56:12 +0100 1466520 http://www.medworm.com/index.php?rid=1466523&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp165k161253072wl%2F Abstract  The aims of the study are (1) assessment of cell surface expression of adhesion molecules CD11b and CD62L on peripheral blood neutrophils in patients with type 2 diabetes and microangiopathy; (2) analysis of serum levels of soluble adhesion molecules: E-selectin (sE-selectin), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and von Willebrand factor (vWF) and; (3) evaluation of systemic inflammatory markers like interleukin-6 (IL-6), soluble interleukin-6 receptor (IL-6Rs), high sensitivity C-reactive protein (hsCRP) and fibrinogen. Thirty patients with type 2 diabetes and microangiopathy were enrolled in the study. The study group was compared to 22 patients with type 2 diabetes without microangiopathic comp... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1466523 Thu, 22 May 2008 05:56:11 +0100 1466523 http://www.medworm.com/index.php?rid=1466522&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0513p6pu4821v4pj%2F Abstract  Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion, peripheral insulin resistance, and increased hepatic glucose production. Genes that contribute to genetic susceptibility to T2DM function in numerous biochemical pathways. Uncoupling protein-2 (UCP2) functions as a negative regulator of insulin secretion. Animal studies show induction of UCP2 plays a pathogenic role in the progression of obesity-induced T2DM and some human studies have shown an association between a common UCP2 polymorphism, Ala55Val (rs660339), and T2DM, obesity, and resting metabolic rate with the Val/Val genotype conferring increased risk. We investigated the relationship between the Ala55Val variant and incidence of T2DM among 12,056 participants in the Atherosclero... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1466522 Thu, 22 May 2008 05:56:11 +0100 1466522 http://www.medworm.com/index.php?rid=1462229&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn673350071613qnx%2F In this study sera from 17 diabetic patients were included, who were exclusively treated with s.c. human insulin, but presenting with severe insulin antibody mediated, immunological insulin resistance (i.e., insulin antibodies, IA). In addition, we included serum from one female patient, previously diagnosed with insulin autoimmune syndrome (no exposure to exogenous insulin treatment, i.e., insulin autoantibodies, IAA). Antibody concentrations and a binding/dissociation analysis was performed by using J125-labelled (position: A-14) human, porcine and bovine insulin according to the protocol described recently. In the patient with insulin autoimmune syndrome (IAA) we observed total crossreactivity between human, bovine and porcine insulin. By contrast, in the group of s.c. insulin tre... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1462229 Wed, 21 May 2008 06:06:24 +0100 1462229 http://www.medworm.com/index.php?rid=1401737&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F004kj65344031178%2F Content Type Journal ArticleCategory AnnouncementDOI 10.1007/s00592-008-0035-x Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 Journal Volume Volume 45 Journal Issue Volume 45, Number 2 / June, 2008 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1401737 Fri, 25 Apr 2008 09:49:32 +0100 1401737 http://www.medworm.com/index.php?rid=1371294&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F90417674m8478217%2F Abstract  The prevalence of obesity has been increasing dramatically in the last decades; the major metabolic complication of obesity is insulin resistance and type-2 diabetes because there are pathogenetic mechanisms linking obesity and type-2 diabetes. Diabetes is also rapidly increasing worldwide; such a description of the key stages in the evolution of type-2 diabetes may be of great interest for implementing antidiabetes treatment. In recent times, type-2 diabetes therapy has been based on drugs, which improve insulin sensibility or stimulate insulin secretion or slow down glucose absorption. Recently, an ADA and EASD consensus has been released to develop a common approach for the management of hyperglycaemia in adults. The development of new classes of blood-glucose-... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1371294 Sat, 12 Apr 2008 08:46:33 +0100 1371294 http://www.medworm.com/index.php?rid=1338963&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe3815x207713720j%2F Content Type Journal ArticleCategory Society NewsDOI 10.1007/s00592-008-0030-2Authors Alberto De Micheli, Azienda Ospedaliera Universitaria San Martino Unità Operativa Diabetologia Largo Rosanna Benzi, 10 16132 Genova Italy Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 (Source: Acta Diabetologica) Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1338963 Sat, 29 Mar 2008 08:58:59 +0100 1338963 http://www.medworm.com/index.php?rid=1321426&cid=s_33260_15_f&fid=33260&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F535782602541h412%2F Abstract  Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are two intermediate states in the transition from normal glucose metabolism to type 2 diabetes. Insulin clamp studies have shown that subjects with IGT have increased insulin resistance in skeletal muscle, while subjects with IFG have near normal muscle insulin sensitivity. Because of the central role of altered free fatty acid (FFA) metabolism in the pathogenesis of insulin resistance, we have examined plasma free fatty acid concentration under fasting conditions, and during OGTT in subjects with IGT and IFG. Seventy-one NGT, 70 IGT and 46 IFG subjects were studied. Fasting plasma FFA in IGT subjects was significantly greater than NGT, while subjects with IFG had similar fasting plasma FFA conce... Acta Diabetologica journals http://www.medworm.com/rss/comments.php?id=1321426 Fri, 21 Mar 2008 08:09:54 +0100 1321426