MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Acta Haematologica' source. Wed, 08 Feb 2012 17:41:55 +0100 http://www.medworm.com/index.php?rid=5664014&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22301888%26dopt%3DAbstract Authors: Carneiro Borba C, de Lourdes Chauffaille M, Saeed Sanabnai S, Folloni Fernandes J, Aiko Kumeda C, Rodrigues Pereira Velloso ED, Jarandilha Dos Santos K, Puato Vieira Pupim M, Hamerschlak N, Odone Filho V, Bendit I Abstract This paper chronicles a 2-year-old girl who presented with acute leukemia/lymphoma syndrome of the T cell immunophenotype. At this time, the cytogenetic analysis of her bone marrow cells showed a reciprocal translocation between the short arm of chromosome 12 and the long arm of chromosome 13, t(12;13)(p13;q14). The immunophenotyping of bone marrow blast cells by flow cytometry revealed a population of cells positive for CD56, CD117, CD45, partial CD33, partial HLA-DR, CD13, CD7, CD2 and CD5. Therefore, a diagnosis of acute leukemia with a mixed T cell/m... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5664014 Wed, 01 Feb 2012 05:00:00 +0100 5664014 http://www.medworm.com/index.php?rid=5664013&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22301942%26dopt%3DAbstract Authors: Mori N, Totsuka K, Ishimori N, Yoshinaga K, Teramura M, Noguchi S, Oda H, Motoji T Abstract A 69-year-old woman with essential thrombocythemia (ET) developed giant ecchymosis, and she was admitted to hospital. Marked anemia (Hb 8.1 g/dl) accompanied by a prolonged activated partial thromboplastin time (89.6 s) was observed, and she received red blood cells (RBC) and fresh frozen plasma (FFP). On day 2 after admission, consciousness disturbance suddenly occurred, whereas computed tomography of the brain showed no evidence of bleeding. As the ecchymosis progressed, she developed shock. Although RBC and FFP transfusions were administered, she developed multi-organ failure and died 48 h after admission. Low factor VIII activity (<1%) accompanied by factor VIII inhibitor (17... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5664013 Wed, 01 Feb 2012 05:00:00 +0100 5664013 http://www.medworm.com/index.php?rid=5664015&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22301865%26dopt%3DAbstract Authors: Hu M, Lin W Abstract Exercise training can increase total Hb and red cell mass, which enhances oxygen-carrying capacity. The possible underlying mechanisms are proposed to come mainly from bone marrow, including stimulated erythropoiesis with hyperplasia of the hematopoietic bone marrow, improvement of the hematopoietic microenvironment induced by exercise training, and hormone- and cytokine-accelerated erythropoiesis. Anemia is one of the most common medical conditions in chronic disease. The effects of exercise training on counteracting anemia have been explored and evaluated. The results of the research available to date are controversial, and it seems that significant methodological limitations exist. However, exercise training might be a promising, additional, safe an... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5664015 Tue, 31 Jan 2012 05:00:00 +0100 5664015 http://www.medworm.com/index.php?rid=5644311&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22286512%26dopt%3DAbstract Authors: Zhu GR, Ji O, Ji JM, Zhang YC, Wu Y, Yu H, Jiang PJ, Shen Q Abstract Imatinib resistance is an important hurdle in the treatment of chronic myeloid leukemia (CML), and CML patients with this drug resistance are often given a dismal prognosis. In this case report, an imatinib-refractory blast phase CML patient was treated with a combination of imatinib and nilotinib. A complete hematologic response was achieved within 3 months, the drug combination was well tolerated, and there was a relatively long bone-marrow complete remission. These results suggest that combining imatinib and nilotinib treatment may improve the outcome of imatinib-resistant CML patients in the blast phase. We hypothesize regarding the possible mechanism for the effectiveness of the drug combination by r... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5644311 Fri, 27 Jan 2012 05:00:00 +0100 5644311 http://www.medworm.com/index.php?rid=5627332&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22262125%26dopt%3DAbstract Authors: Molica S, Gentile M, Mauro FR, Brugiatelli M, Federico M, Sperduti I, Neri A, Ferrarini M, Foà R, Morabito F Abstract No abstract available. PMID: 22262125 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5627332 Thu, 19 Jan 2012 05:00:00 +0100 5627332 http://www.medworm.com/index.php?rid=5607297&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236870%26dopt%3DAbstract Authors: Wang H, Cao J, Hong X Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematological malignancy derived from precursors of plasmacytoid dendritic cells. This disease typically presents with cutaneous involvement as the first manifestation, with subsequent or simultaneous spread to bone marrow and peripheral blood. It is exceedingly rare to diagnose BPDCN without a cutaneous lesion. Here, we report a 21-year-old male who was diagnosed with BPDCN in the absence of cutaneous symptoms. Clinically, left inguinal nodules were noticed for 4 months. The diagnosis of BPDCN was established based on histological and immunohistochemical study of a lymph node biopsy. The patient was classified as stage IVA with bone marrow involvement and un... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5607297 Thu, 12 Jan 2012 05:00:00 +0100 5607297 http://www.medworm.com/index.php?rid=5607296&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236942%26dopt%3DAbstract Conclusions: The endoscopic findings in GI MCL are variable, with common presenting manifestations of abdominal pain and GI bleeding. PMID: 22236942 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5607296 Thu, 12 Jan 2012 05:00:00 +0100 5607296 http://www.medworm.com/index.php?rid=5607295&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22248505%26dopt%3DAbstract Conclusions: Our cases indicate that IM combined with daunorubicin-based chemotherapy followed by allo-HSCT and IM maintenance treatment is associated with a favorable outcome for de novo Ph+ AML, especially when IM is used in an early phase of AML. PMID: 22248505 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5607295 Thu, 12 Jan 2012 05:00:00 +0100 5607295 http://www.medworm.com/index.php?rid=5607294&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22249155%26dopt%3DAbstract In this report, we explain the process and steps involved in obtaining a valid lab-specific conversion factor for expressing BCR-ABL1 transcript levels in the IS. PMID: 22249155 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5607294 Thu, 12 Jan 2012 05:00:00 +0100 5607294 http://www.medworm.com/index.php?rid=5607298&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236811%26dopt%3DAbstract Authors: Yang JJ, Park TS, Choi JR, Park SJ, Cho SY, Jun KR, Kim HR, Lee JN, Oh SH, Lee S, Kim B, Marschalek R, Meyer C Abstract No abstract available. PMID: 22236811 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5607298 Wed, 11 Jan 2012 05:00:00 +0100 5607298 http://www.medworm.com/index.php?rid=5607299&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236776%26dopt%3DAbstract Authors: Marisavljevic D Abstract No abstract available. PMID: 22236776 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5607299 Sat, 07 Jan 2012 05:00:00 +0100 5607299 http://www.medworm.com/index.php?rid=5568785&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22212303%26dopt%3DAbstract Authors: Dujmovic D, Aurer I, Radman I, Serventi-Seiwerth R, Dotlic S, Stern-Padovan R, Dubravcic K, Santek F, Labar B PMID: 22212303 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5568785 Sat, 31 Dec 2011 05:00:00 +0100 5568785 http://www.medworm.com/index.php?rid=5538957&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178955%26dopt%3DAbstract Authors: Hardak E, Oren I, Dann EJ, Yigla M, Faibish T, Rowe JM, Avivi I Abstract Recent studies suggest an increased risk for Pneumocystis jirovecii pneumonia (PJP) in adults receiving short-interval rituximab-CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) therapy for diffuse large cell B cell lymphoma (DLBCL). This retrospective study evaluates precise PJP incidence and the efficacy of anti-PJP prophylaxis in DLBCL. Patients with DLBCL, aged ≥18 years and treated between December 2004 and December 2010, were included. Details of treatment-related respiratory infections, focusing on PJP incidence, risk factors and prophylaxis, were assessed. A total of 132 patients were analyzed; 47 were treated with rituximab-CHOP therapy every 21 days (R-CHOP-21) and 85 were ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5538957 Fri, 16 Dec 2011 05:00:00 +0100 5538957 http://www.medworm.com/index.php?rid=5538960&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178718%26dopt%3DAbstract Authors: Ohata K, Iwaki N, Kotani T, Kondo Y, Yamazaki H, Nakao S Abstract Lymphoproliferative disorders (LPDs) are generally caused by uncontrolled B-cell proliferation induced by the Epstein-Barr virus (EBV) in the setting of impaired EBV-specific T-cell immunity, particularly when there is pharmacological immunosuppression including antithymocyte globulin. We herein present an unusual case of EBV associated with LPD (EBV-LPD) in which LPD occurred 3 weeks after the use of rabbit antithymocyte globulin administered for severe hepatitis-associated aplastic anemia; the patient died of fulminant leukemic lymphoma 5 days after the onset. We also review the pertinent literature on EBV-LPD after immunosuppressive therapy and document the efficacy of EBV viral load monitoring and the ne... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5538960 Thu, 15 Dec 2011 05:00:00 +0100 5538960 http://www.medworm.com/index.php?rid=5538959&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178776%26dopt%3DAbstract Conclusion: pTY-MZL tends to be an indolent disease. However, unlike other mucosa-associated lymphoid tissue site MZLs, pTY-MZL was well controlled via several treatment modalities, and the patients' responses were sustained for a prolonged period. PMID: 22178776 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5538959 Thu, 15 Dec 2011 05:00:00 +0100 5538959 http://www.medworm.com/index.php?rid=5538958&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22178869%26dopt%3DAbstract Authors: Xu LH, Fang JP, Hong DL, Wu YF Abstract Sensitized patients are at high risk for graft rejection during transplantation. It is of interest to investigate the effect of mesenchymal stromal cells (MSCs) in sensitized hematopoietic stem cell transplantation. MSCs were generated from bone marrow cells of BALB/c mice. The molecular markers of MSCs were detected by flow cytometry. MSCs labeled with green fluorescent dye were transplanted into nonsensitized and sensitized recipients, respectively. Homing of MSCs in vivo was monitored at different time points post-transplantation. Additionally, sensitized BALB/c mice under irradiation were transplanted with syngeneic MSCs and allogeneic bone marrow cells, and the rate of survival was monitored daily. The fourth passage of MSCs pre... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5538958 Thu, 15 Dec 2011 05:00:00 +0100 5538958 http://www.medworm.com/index.php?rid=5538971&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22156510%26dopt%3DAbstract This report extends the literature of central nervous system RS and particularly highlights the importance of a thorough diagnostic evaluation of patients with low-grade NHL presenting with neurological symptoms. PMID: 22156510 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5538971 Sat, 10 Dec 2011 05:00:00 +0100 5538971 http://www.medworm.com/index.php?rid=5539008&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22156491%26dopt%3DAbstract Authors: Ayhan AC, Timur C, Ayhan Y, Cakır B, Erguven M Abstract Hypereosinophilic syndrome (HES) and the association of hypereosinophilia with acute lymphoblastic leukaemia (ALL) are both rare in children. Some acute myelogenous leukaemias can present with eosinophilia, but the relationship between HES and ALL is not well known and is rarer than the relationship between HES and acute myelogenous leukaemia. Patients are diagnosed with HES when no cause is found to explain the eosinophilia leading to end organ damage. For this reason, it is recommended that patients presenting with hypereosinophilia be carefully assessed to exclude any malignant clonal proliferation. HES may present with severe clinical manifestations such as high leucocyte count, anaemia, thrombocytopaenia, hepato... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5539008 Tue, 06 Dec 2011 05:00:00 +0100 5539008 http://www.medworm.com/index.php?rid=5496791&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22143083%26dopt%3DAbstract In conclusion, the allogeneic PBSCT outcomes for AML were comparable in the matched related and matched unrelated groups. Nonetheless, for high-risk AML patients, matched unrelated PBSCT was found to be preferable to matched related PBSCT. PMID: 22143083 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5496791 Tue, 06 Dec 2011 05:00:00 +0100 5496791 http://www.medworm.com/index.php?rid=5496792&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22134139%26dopt%3DAbstract Conclusions: These results demonstrate that the 4G/5G polymorphism of the PAI-1 gene affects the plasma PAI-1 concentration, which could impair fibrinolysis and cause organ failure, and thus the presence of the 4G allele increases the risk of death. PMID: 22134139 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5496792 Tue, 29 Nov 2011 05:00:00 +0100 5496792 http://www.medworm.com/index.php?rid=5496793&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22104247%26dopt%3DAbstract Authors: Park BG, Chi HS, Park SJ, Min SK, Jang S, Park CJ, Kim DY, Lee JH, Lee JH, Lee KH Abstract Mutations in the nucleophosmin (NPM1) and fms-like tyrosine kinase-3 (FLT3) genes are the most commonly observed mutations in patients with normal-karyotype acute myeloid leukemia (AML-NK). We analyzed the prognostic effects and interactions of these mutations in 201 AML-NK patients. NPM1 and FLT3 mutations were found in 38.3 and 24.9% of AML-NK patients, respectively. NPM1 mutations (NPM1mut), especially in patients without FLT3 mutations (FLT3mut), were associated with a favorable outcome. However, NPM1mut did not affect survival. FLT3mut tended to be associated with a poor survival outcome. FLT3mut showed no prognostic effects in patients with A-type NPM1mut. However, FLT3mut were... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5496793 Fri, 18 Nov 2011 05:00:00 +0100 5496793 http://www.medworm.com/index.php?rid=5428231&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22094354%26dopt%3DAbstract Authors: Serpa M, Sanabani SS, Dorlhiac-Llacer PE, Nardinelli L, de Barros Ferreira P, Borges Martins TF, Seguro F, Bendit I Abstract Despite the beneficial effects of imatinib mesylate, some patients may either not respond or respond suboptimally. Here, we report two chronic myelogenous leukemia patients; one had a suboptimal response according to European LeukemiaNet criteria (a major molecular response was not achieved after 18 months of standard-dose imatinib therapy) and the other had failure with a standard dose of imatinib. At the time of the suboptimal response in patient 1 and the failure in patient 2, we were able to detect the F359I mutation in the BCR-ABL tyrosine kinase domain using DNA sequencing in both patients. Therefore, it was decided to change the therapeutic re... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5428231 Thu, 17 Nov 2011 05:00:00 +0100 5428231 http://www.medworm.com/index.php?rid=5428230&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22094378%26dopt%3DAbstract Authors: Malato A, Santoro A, Felice R, Magrin S, Turri D, Bica MG, Salemi D, Fabbiano F PMID: 22094378 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5428230 Thu, 17 Nov 2011 05:00:00 +0100 5428230 http://www.medworm.com/index.php?rid=5383475&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22042243%26dopt%3DAbstract Conclusion: Given the modern migratory flows, greater knowledge of these disorders is needed by all medical staff, and new practical and cost/time-effective diagnostic approaches have to be devised. PMID: 22042243 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5383475 Tue, 25 Oct 2011 04:00:00 +0100 5383475 http://www.medworm.com/index.php?rid=5348213&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22025110%26dopt%3DAbstract Authors: Xiao X, Zhang Y, Zhang GS, Zheng WL, Xiao L, Liu SF Abstract No abstract available. PMID: 22025110 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5348213 Wed, 19 Oct 2011 04:00:00 +0100 5348213 http://www.medworm.com/index.php?rid=5348214&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22025082%26dopt%3DAbstract Authors: Yang JJ, Oh SH, Cho SY, Suh JT, Lee HJ, Lee WI, Lee J, Baek SK, Yoon HJ, Cho EH, Park TS Abstract No abstract available. PMID: 22025082 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5348214 Tue, 18 Oct 2011 04:00:00 +0100 5348214 http://www.medworm.com/index.php?rid=5348215&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22005133%26dopt%3DAbstract Conclusion: For patients with TKI resistance, mutation and ACA screening may play a role in identifying patients with poorer prognosis. PMID: 22005133 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5348215 Fri, 14 Oct 2011 04:00:00 +0100 5348215 http://www.medworm.com/index.php?rid=5348217&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21996674%26dopt%3DAbstract Authors: Shet AS, Pinto SM, Mitra G, Mandal AK Abstract There are few good biomarkers of iron deficiency anemia (IDA). Since IDA patients have evidence for increased oxidative stress, we used mass spectrometry (MS) [i.e. matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization] to identify novel biomarkers. Using MALDI-MS, the following oxidative modifications of hemoglobin with the following mass-to-charge ratios were identified: 1,087.5 (α32-40), 1,545.7 (α17-31), 1,290.0 (β31-40) and 2,076.1 (β41-59). On electrospray ionization MS, the IDA patients had significantly elevated glutathionyl hemoglobin (GSHb) compared with the controls (16.9 ± 9.6 vs. 7.7 ± 3.7%; p = 0.002). GSHb levels correlated inversely with serum ferritin (Spearman rho -0.485; p = 0... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5348217 Thu, 13 Oct 2011 04:00:00 +0100 5348217 http://www.medworm.com/index.php?rid=5348216&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21996727%26dopt%3DAbstract Authors: Jorgensen LN, Gewert K Abstract No abstract available. PMID: 21996727 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5348216 Thu, 13 Oct 2011 04:00:00 +0100 5348216 http://www.medworm.com/index.php?rid=5348219&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21996575%26dopt%3DAbstract In conclusion, our results indicate that low-dose rituximab might be an effective and safe treatment for patients with acquired FVIII inhibitor. PMID: 21996575 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5348219 Wed, 12 Oct 2011 04:00:00 +0100 5348219 http://www.medworm.com/index.php?rid=5348218&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21996611%26dopt%3DAbstract Authors: Martino M, Console G, Russo L, Messina G, D'Arro' BL, Irrera G, Barreca G Abstract No abstract available. PMID: 21996611 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5348218 Wed, 12 Oct 2011 04:00:00 +0100 5348218 http://www.medworm.com/index.php?rid=5348221&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21986307%26dopt%3DAbstract This report concerns the effect of cyclosporin A (CsA) on chemotherapy-refractory AITL. A 68-year-old female with AITL with systemic symptoms, such as high fever, skin rash andgeneralized lymphadenopathy, was initially treated with conventional cytotoxic chemotherapies using alkylators, anthracyclines and corticosteroids, which failed to induce remission. However, CsA (4 mg/kg/day) plus dexamethasone treatment resulted in a dramatic regression of the tumors and amelioration of systemic symptoms and induced complete remission (CR) within 2 weeks. Currently, the patient's CR has continued for more than 18 months with CsA maintenance therapy. Our experience and previously reported findings suggest that CsA may constitute an alternative treatment option for AITL, even though the use of convent... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5348221 Fri, 07 Oct 2011 04:00:00 +0100 5348221 http://www.medworm.com/index.php?rid=5348220&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21986343%26dopt%3DAbstract Authors: Dittmann K, Przybylski GK, Grabarczyk P, Dölken G, Gesk S, Siebert R, Schmidt CA Abstract Chromosomal abnormalities, like deletions, amplifications, inversions or translocations, are recurrent features in haematological malignancies. However, the precise molecular breakpoints are frequently not determined. Here we describe a rapid analysis of genetic imbalances combining fine tiling comparative genomic hybridization (FT-CGH) and ligation-mediated PCR (LM-PCR). We clarified an inv(14)(q11q32) in a case of T cell acute lymphoblastic leukaemia with a breakpoint in the TRA/D in 68% of cells detected by fluorescence in situ hybridization. FT-CGH showed several mono- and biallelic losses within TRA/D. LM-PCR disclosed a TRA/D rearrangement on one allele. The other allele reveal... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5348220 Fri, 07 Oct 2011 04:00:00 +0100 5348220 http://www.medworm.com/index.php?rid=5284277&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21951998%26dopt%3DAbstract Authors: Kim JL, Kang HN, Kang MH, Yoo YA, Kim JS, Choi CW Abstract No abstract available. PMID: 21951998 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5284277 Tue, 27 Sep 2011 04:00:00 +0100 5284277 http://www.medworm.com/index.php?rid=5284275&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21952689%26dopt%3DAbstract Authors: Cartoafa M, Kahatt C, Soto-Matos A, Roy E, Lardelli P Abstract No abstract available. PMID: 21952689 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5284275 Sat, 24 Sep 2011 04:00:00 +0100 5284275 http://www.medworm.com/index.php?rid=5284274&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21952727%26dopt%3DAbstract Authors: Liu SV, Douer D Abstract No abstract available. PMID: 21952727 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5284274 Sat, 24 Sep 2011 04:00:00 +0100 5284274 http://www.medworm.com/index.php?rid=5284276&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21952642%26dopt%3DAbstract Authors: Bacher U, Ocheni S, Schafhausen P, Oyekunle A, Dierlamm J, Zander AR, Bokemeyer C, Haferlach T, Kröger N Abstract No abstract available. PMID: 21952642 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5284276 Thu, 22 Sep 2011 04:00:00 +0100 5284276 http://www.medworm.com/index.php?rid=5249688&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934298%26dopt%3DAbstract Conclusion: The marked sensitivity of erythroid progenitor cells from β-thal/HbE patients to cytokine-induced apoptosis via an NO-mediated process reflects a proapoptotic status of such thalassemic red blood cells. PMID: 21934298 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5249688 Wed, 21 Sep 2011 04:00:00 +0100 5249688 http://www.medworm.com/index.php?rid=5249687&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934299%26dopt%3DAbstract Authors: Paschos P, Vlachaki E, Pasvanti C, Sinakos E, Kalpaka A, Klonizakis P, Perifanis V Abstract No abstract available. PMID: 21934299 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5249687 Wed, 21 Sep 2011 04:00:00 +0100 5249687 http://www.medworm.com/index.php?rid=5249690&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934296%26dopt%3DAbstract Authors: Qi X, Tan Y, Chen X, Bian S, Zhang L, Xu A, Xu Z, Wang H Abstract No abstract available. PMID: 21934296 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5249690 Tue, 20 Sep 2011 04:00:00 +0100 5249690 http://www.medworm.com/index.php?rid=5249689&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934297%26dopt%3DAbstract Authors: Weng WH, Shih LY PMID: 21934297 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5249689 Tue, 20 Sep 2011 04:00:00 +0100 5249689 http://www.medworm.com/index.php?rid=5249693&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934293%26dopt%3DAbstract In conclusion, we found that CML cells have a low BRIT1/MCPH1 level and show a defective G2/M arrest, confirming that these cells have a constitutive genomic instability. PMID: 21934293 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5249693 Fri, 16 Sep 2011 04:00:00 +0100 5249693 http://www.medworm.com/index.php?rid=5249692&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934294%26dopt%3DAbstract Authors: Loschi M, Jouen F, Kerleau JM, Tilly H, Jardin F Abstract No abstract available. PMID: 21934294 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5249692 Fri, 16 Sep 2011 04:00:00 +0100 5249692 http://www.medworm.com/index.php?rid=5249691&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934295%26dopt%3DAbstract Authors: Langabeer SE, Haslam K, Kelly J, Leahy M, Vandenberghe E Abstract No abstract available. PMID: 21934295 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5249691 Fri, 16 Sep 2011 04:00:00 +0100 5249691 http://www.medworm.com/index.php?rid=5160408&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21860227%26dopt%3DAbstract We present 2 patients with chronic immune thrombocytopenic purpura (ITP) secondary to Candida albicans infection. Neither patient responded to standard ITP therapy including splenectomy. Appropriate antifungal treatment of the C. albicans infection was followed by sustained improvement in platelet count in both patients. To our knowledge, this is the first report of ITP in association with C. albicans infection. PMID: 21860227 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5160408 Mon, 22 Aug 2011 23:00:00 +0100 5160408 http://www.medworm.com/index.php?rid=5142975&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21849771%26dopt%3DAbstract Authors: Suyanı E, Yağcı M, Sucak GT Abstract No abstract available. PMID: 21849771 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5142975 Wed, 17 Aug 2011 23:00:00 +0100 5142975 http://www.medworm.com/index.php?rid=5142976&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21846973%26dopt%3DAbstract Authors: Lee SG, Park TS, Oh SH, Park JC, Yang YJ, Marschalek R, Meyer C, Cho EH, Shin SY Abstract No abstract available. PMID: 21846973 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5142976 Mon, 15 Aug 2011 23:00:00 +0100 5142976 http://www.medworm.com/index.php?rid=5142978&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21846971%26dopt%3DAbstract Conclusion: In Estonia, a remarkable improvement in outcome for young de novo AL patients was seen after 1996. Nevertheless, relative survival for the Estonian patients had still not reached the levels found in the Swedish cohort. PMID: 21846971 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5142978 Fri, 12 Aug 2011 23:00:00 +0100 5142978 http://www.medworm.com/index.php?rid=5142977&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21846972%26dopt%3DAbstract Conclusion: A relatively higher proportion of HCL-V in all HCL comparing to Westerners is observed. Second malignancies are common. With an inferior outcome and dismal response to most treatment, enrollment in a clinical trial should be considered for HCL-V. PMID: 21846972 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5142977 Fri, 12 Aug 2011 23:00:00 +0100 5142977 http://www.medworm.com/index.php?rid=5113122&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21811059%26dopt%3DAbstract In conclusion, H. pylori infection upregulates platelet counts mainly in females, and eradication reduced peripheral platelets in both sexes. Females appeared more susceptible to H. pylori infection than males with regard to upregulation of platelet counts. PMID: 21811059 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5113122 Fri, 29 Jul 2011 23:00:00 +0100 5113122 http://www.medworm.com/index.php?rid=5113123&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21791913%26dopt%3DAbstract Authors: Lee SG, Lim G, Cho SY, Suh JT, Lee HJ, Baek SK, Lee WI, Yoon HJ, Park TS No abstract available. PMID: 21791913 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5113123 Tue, 26 Jul 2011 23:00:00 +0100 5113123 http://www.medworm.com/index.php?rid=5113124&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21778706%26dopt%3DAbstract This report presents the totality of evidence through a systematic review that assessed either the efficacy or safety of bortezomib-based regimens in multiple myeloma with renal impairment. A systematic and comprehensive search of the literature was performed using MEDLINE databases from 1978 to December 1, 2010, and a hand search of references. We used the following medical subject headings (MESH) to identify potential studies: 'myeloma renal failure' (1,225 hits) and 'bortezomib' (2,554 hits). An additional search performed by combining the MESH terms 'myeloma renal failure' and 'bortezomib' yielded 50 citations. Five additional case-control studies judged relevant for the purpose of study were also included. In total, 6 case reports, 9 case series and 9 case-control studies were identif... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5113124 Wed, 20 Jul 2011 23:00:00 +0100 5113124 http://www.medworm.com/index.php?rid=5113125&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21778705%26dopt%3DAbstract Conclusion: From this study it can be concluded that LDH is a significant biochemical marker for the severity of pain during a vaso-occlusive episode in SCD. PMID: 21778705 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5113125 Tue, 19 Jul 2011 23:00:00 +0100 5113125 http://www.medworm.com/index.php?rid=5113128&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21757886%26dopt%3DAbstract We describe herein the successful treatment of severe autoimmune hemolytic anemia (AIHA) in a patient with multicentric Castleman disease (MCD) by humanized anti-interleukin-6 (IL-6) receptor antibody (tocilizumab) therapy. Inflammatory anemia is commonly reported; however, AIHA is a very rare complication of MCD. In 1996, a 45-year-old Japanese woman was referred to our hospital because of generalized lymphadenopathy, anemia and skin eruptions. Lymph node biopsy demonstrated MCD. She was treated with prednisolone (1 mg/kg/day), which improved the anemia and skin eruptions. In 2009, she suddenly developed Coombs-positive hemolytic anemia. The blood count was as follows: hemoglobin 4.7 g/dl, platelets 490 × 10(9)/l and white blood cell count 9.8 × 10(9)/l. Both direct and indirect Coombs'... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5113128 Wed, 13 Jul 2011 23:00:00 +0100 5113128 http://www.medworm.com/index.php?rid=5113127&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21757887%26dopt%3DAbstract Authors: Plaseska-Karanfilska D, Dimovski A PMID: 21757887 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5113127 Wed, 13 Jul 2011 23:00:00 +0100 5113127 http://www.medworm.com/index.php?rid=5113126&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21757888%26dopt%3DAbstract We describe a 67-year-old female patient who presented with an atypical course of tAPL. Atypical features in this patient's course included a preceding therapy-related myelodysplastic syndrome (MDS) with a slowly expanding pathological promyelocyte clone. Following treatment with all-trans-retinoic acid and arsenic trioxide, the patient achieved complete clinical, morphological and molecular remission. Review of the pertinent literature highlights the rarity of MDS transforming into APL, although dysplasia has been shown to be a possible feature of tAPL. MDS may be an underdiagnosed stage in tAPL leukomogenesis. This case also underscores the complexity of clinical decision-making in the context of tAPL. PMID: 21757888 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5113126 Wed, 13 Jul 2011 23:00:00 +0100 5113126 http://www.medworm.com/index.php?rid=5019539&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21734365%26dopt%3DAbstract Authors: Chaudhry MS, Mather H, Marks A, Naresh K Primary lymphoma of bone is extremely rare. There are increasing reports of lymphoma arising in bone adjacent to metallic prostheses. Herein, we describe the case of a 76-year-old man who developed diffuse large B cell lymphoma in the tibia 3 years after total knee arthroplasty for osteoarthritis. A review of the literature has identified 11 other cases of lymphoma arising in the context of orthopaedic metallic implants. To our knowledge this is the first reported case of a primary lymphoma arising in bone adjacent to a knee prosthesis. Possible pathogenetic mechanisms may include chronic antigenic stimulation of lymphocytes, proliferation of EBV-infected B lymphocytes, and direct mutagenic effects of metallic ions. Further research is ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5019539 Wed, 06 Jul 2011 23:00:00 +0100 5019539 http://www.medworm.com/index.php?rid=5019543&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21701157%26dopt%3DAbstract We present a case of an 80-year-old man with a CD4+CD56+ BPDCN that affected the orbital cavity and bone marrow. Although BPDCN has not been reported to express any lineage-specific markers, the neoplastic cells strongly expressed the CD13 antigen. Therefore, in addition to pathological examination, we attempted to induce in vitro morphological and surface marker changes with IL-3 and CD40 ligand. After treatment with these cytokines, the tumor cells enlarged markedly, acquired many fine dendrites, similar to mature DC, and showed enhanced expression of antigens specific to DC or antigen-presenting cells, such as CD40, CD80, CD83 and CD86. To the best of our knowledge, this is the first report of BPDCN expressing a myeloid antigen, CD13, although CD33 expression has been described in some ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5019543 Thu, 23 Jun 2011 23:00:00 +0100 5019543 http://www.medworm.com/index.php?rid=5019542&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21701158%26dopt%3DAbstract We present the case of a 67-year-old Caucasian male with NT-AML M0 who had an unusually long first complete remission of 51 months and an overall survival of 80 months. The only characteristic distinguishing him from other previously described patients with NT-AML was the absence of erythroblastic and/or megakaryocytic dysplasia (EMD) at diagnosis. Molecular-genetic testing for AML fusion transcripts associated with a favorable prognosis (PML/RARα,AML1/ETO, and CBFβ/MYH11) were negative, as were other prognostic markers like MLL-PTD,FLT3-ITD, or mutations of FLT3-D835,NPM1, or CEBPA. Expression studies of ERG,MN1, and EVI1 revealed overexpression of ERG only. The absence of EMD may be a useful prognostic/diagnostic feature of this new rare subtype of NT-AML. PMID: 21701158 [PubMed - ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5019542 Thu, 23 Jun 2011 23:00:00 +0100 5019542 http://www.medworm.com/index.php?rid=5019541&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21701159%26dopt%3DAbstract We report a case of AAMT which was successfully treated with azathioprine 3 mg/kg/day. The clinical bleeding tendency resolved after treatment for 4 weeks and complete remission was documented after 6 weeks. Azathioprine treatment for AAMT is low risk, convenient, and cost-effective. Our successful experience suggests that azathioprine is potentially the treatment of choice after steroid failure. PMID: 21701159 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5019541 Thu, 23 Jun 2011 23:00:00 +0100 5019541 http://www.medworm.com/index.php?rid=5019540&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21701160%26dopt%3DAbstract Authors: Barton JC, Barton JC No abstract available. PMID: 21701160 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=5019540 Thu, 23 Jun 2011 23:00:00 +0100 5019540 http://www.medworm.com/index.php?rid=4924233&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21659727%26dopt%3DAbstract We present 2 patients with hyperferritinemia, increased liver iron and hemochromatosis-associated HFE genotypes. At diagnosis, both patients had chronic anemia that prevented initiation of phlebotomy. Iron chelation with deferasirox proved to be a safe and effective means of substantially lowering ferritin levels. PMID: 21659727 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4924233 Thu, 09 Jun 2011 23:00:00 +0100 4924233 http://www.medworm.com/index.php?rid=4924240&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21654161%26dopt%3DAbstract We describe here the clinical course of one such rare patient with Ab-mediated PRCA. The patient was a 70-year-old man with chronic renal failure secondary to diabetic nephropathy. He had not received rhEPO therapy before the initiation of hemodialysis. He started hemodialysis and began to receive rhEPO therapy intravenously. Three months later, his hemoglobin level started declining and he became transfusion dependent. A diagnosis of Ab-mediated PRCA was made by bone marrow examination and detection of anti-EPO Abs. He was successfully treated with cyclosporine and became independent of blood transfusions. This case is a reminder that vigilance is required regarding the development of Ab-mediated PRCA upon rhEPO therapy, regardless of the administration route. PMID: 21654161 [PubMed -... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4924240 Mon, 06 Jun 2011 23:00:00 +0100 4924240 http://www.medworm.com/index.php?rid=4924252&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21646778%26dopt%3DAbstract Authors: Cho SY, Oh SH, Suh JT, Lee HJ, Lee WI, Baek SK, Cho KS, Park TS No abstract available. PMID: 21646778 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4924252 Tue, 31 May 2011 23:00:00 +0100 4924252 http://www.medworm.com/index.php?rid=4877683&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21597283%26dopt%3DAbstract We report a previously undescribed case of PNH occurring after autologous stem cell transplantation (ASCT) in a patient affected by relapsing non-Hodgkin's lymphoma. The intensive chemotherapy and the ASCT resulted in a contraction of the effective hematopoietic stem cell (HSC) pool and a derangement of the immune system. The delayed engraftment and the BM hypoplasia represented a favorable environment for the expansion of the pathological clone. This case is paradigmatic even for the unexpected trend of the PNH clone during treatment with the terminal complement inhibitor eculizumab; in fact, the clone reduced until undergoing unexpected extinction, i.e. the recovery of normal hematopoiesis. Eculizumab seems not to play a direct role in HSC kinetics; the clinical remission probably occurr... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4877683 Wed, 18 May 2011 23:00:00 +0100 4877683 http://www.medworm.com/index.php?rid=4877684&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21576935%26dopt%3DAbstract Authors: Costa R, Khattab M, Gilmore GL, Sahovic EA, Miller SM, Rossetti JM, Abdulhaq H, Lister J No abstract available. PMID: 21576935 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4877684 Mon, 16 May 2011 23:00:00 +0100 4877684 http://www.medworm.com/index.php?rid=4877685&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21576934%26dopt%3DAbstract Conclusion: We describe a phytosterolemia patient whose clinical manifestations were macrothrombocytopenia, stomatocytic hemolysis and splenomegaly, without the common features of this disorder. Our results suggest that blood cells could be a target for the toxic effect of plasma plant sterols, which should be measured in patients with unexplained stomatocytosis and/or macrothrombocytopenia in order to determine if they have phytosterolemia. PMID: 21576934 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4877685 Wed, 11 May 2011 23:00:00 +0100 4877685 http://www.medworm.com/index.php?rid=4877686&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21576933%26dopt%3DAbstract Authors: Lai ME, Vacquer S, Carta MP, Spiga A, Cocco P, Abete C, Dessì S, Mandas A The purpose of this study was to focus on pathophysiological mechanisms linking β-thalassemia intermedia (β-TI) and minor (β-TMI) with cardiovascular risk. Iron status, prooxidant-antioxidant balance and lipid profiles in serum, and lipid content in peripheral blood mononuclear cells (PBMCs) were evaluated in 20 β-TMI subjects, 22 β-TI patients and in 30 nonthalassemic blood donors. The mRNA levels of some genes involved in the regulation of iron and cholesterol metabolism were also determined. In β-TI and in β-TMI, serum iron, prooxidant-antioxidant ratio, transferrin saturation and erythropoietin levels were higher, while transferrin and hepcidin were lower compared to controls. Hepcidin and in... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4877686 Tue, 10 May 2011 23:00:00 +0100 4877686 http://www.medworm.com/index.php?rid=4824693&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21540579%26dopt%3DAbstract Conclusions: Pretreatment serum level of 15-kDa granulysin may be a valuable prognostic marker in DLBCL patients treated with standard chemotherapy. PMID: 21540579 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4824693 Tue, 03 May 2011 23:00:00 +0100 4824693 http://www.medworm.com/index.php?rid=4824694&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21502754%26dopt%3DAbstract Authors: Liu SV, Zneimer S, Tahbaz A, Douer D No abstract available. PMID: 21502754 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4824694 Sun, 17 Apr 2011 23:00:00 +0100 4824694 http://www.medworm.com/index.php?rid=4722113&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21494030%26dopt%3DAbstract Conclusion: These results suggest that alterations of the SNF5 gene are rare in hematological neoplasms with chromosome 22 abnormalities. Haploinsufficiency may contribute to the development of these neoplasms. PMID: 21494030 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4722113 Tue, 12 Apr 2011 23:00:00 +0100 4722113 http://www.medworm.com/index.php?rid=4722114&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21487214%26dopt%3DAbstract Authors: Heimpel H No abstract available. PMID: 21487214 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4722114 Sun, 10 Apr 2011 23:00:00 +0100 4722114 http://www.medworm.com/index.php?rid=4722118&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21474922%26dopt%3DAbstract Conclusions: Identification of an abnormal TIMP/MMP ratio in all three diseases, regardless of the JAK2 status, indicates invariable marrow remodeling. In this particular group of patients, presence of a JAK2(V617F) mutation, being associated with even higher ratios, appears to be a concurring participant in bone marrow-reforming processes. Additional research may delineate correlates with the JAK2 allelic burden. PMID: 21474922 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4722118 Wed, 06 Apr 2011 23:00:00 +0100 4722118 http://www.medworm.com/index.php?rid=4722116&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21474923%26dopt%3DAbstract Authors: Stewart DM, Ramanathan R, Mahanty S, Fedorko DP, Janik JE, Morris JC A 55-year-old woman with human T-cell lymphotropic virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL) and a history of previously treated Strongyloides stercoralis infection received anti-CD52 monoclonal antibody therapy with alemtuzumab on a clinical trial. After an initial response, she developed ocular involvement by ATL. Alemtuzumab was stopped and high-dose corticosteroid therapy was started to palliate her ocular symptoms. Ten days later, the patient developed diarrhea, vomiting, fever, cough, skin rash, and a deteriorating mental status. She was diagnosed with disseminated S. stercoralis. Corticosteroids were discontinued and the patient received anthelmintic therapy with ivermectin and alben... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4722116 Wed, 06 Apr 2011 23:00:00 +0100 4722116 http://www.medworm.com/index.php?rid=4669122&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21454967%26dopt%3DAbstract Authors: Belotti A, Doni E, Elli E, Rossi V, Pioltelli P, Pogliani EM No abstract available. PMID: 21454967 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4669122 Wed, 30 Mar 2011 23:00:00 +0100 4669122 http://www.medworm.com/index.php?rid=4669161&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21430371%26dopt%3DAbstract Authors: Gaudio F, Giordano A, Perrone T, Pastore D, Curci P, Delia M, Napoli A, De' Risi C, Spina A, Ricco R, Liso V, Specchia G The aim of this study was to evaluate the impact of clinical variables and biologic features on response rate (RR), overall survival (OS) and progression-free survival (PFS) in 111 patients with de novo diffuse large B cell lymphoma (DLBCL). Fifty-three patients were treated with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) and 58 patients were treated with R-CHOP (rituximab + CHOP). The variables predictive of RR in the CHOP group were B symptoms, age, clinical stage, bone marrow involvement, bulky disease, International Prognostic Index (IPI) and Bcl-2; in the R-CHOP group, these variables were bulky disease, bone marrow involvement, ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4669161 Thu, 24 Mar 2011 00:00:00 +0100 4669161 http://www.medworm.com/index.php?rid=4669162&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21430370%26dopt%3DAbstract Authors: Kourelis TV, Kahl BS, Benn P, Delach JA, Bilgrami SF Herein, we describe a case of a female patient in whom B cell chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) were diagnosed simultaneously. She presented with anemia, thrombocytopenia and splenomegaly. Flow cytometry demonstrated two immunophenotypically distinct CD5-positive monoclonal B cell populations. Peripheral blood fluorescence in situ hybridization (FISH) was positive for IGH/CCND1, consistent with t(11;14) translocation. She received 6 cycles of bendamustine 70 mg/m(2)/day for 2 days and rituximab on the first day every 4 weeks along with granulocyte-colony stimulating factor. She had an excellent response, and repeat computed tomography after her third cycle of chemotherapy revealed no organomeg... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4669162 Wed, 23 Mar 2011 00:00:00 +0100 4669162 http://www.medworm.com/index.php?rid=4609535&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411984%26dopt%3DAbstract We report a case of chemotherapy-resistant SPTL with hemophagocytic syndrome (HPS) which was successfully treated with cyclosporine A (CsA) plus methylprednisolone (mPSL), and also reviewed 11 SPTL cases treated with CsA, previously reported in the literature. Our patient was a 38-year-old female with SPTL. The disease progressed despite conventional chemotherapy using cytotoxic agents including alkylators, anthracyclins or purine analogues, and, after 2 months of chemotherapy, was eventually complicated by HPS and disseminated intravascular coagulation (DIC). CsA (4 mg/kg/day) plus mPSL treatment dramatically improved HPS with DIC, reduced subcutaneous tumors within 2 weeks, and finally induced complete remission (CR) after 3 months. Currently, the patient has maintained CR while being tr... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4609535 Thu, 17 Mar 2011 00:00:00 +0100 4609535 http://www.medworm.com/index.php?rid=4609534&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411985%26dopt%3DAbstract Authors: De Angelis C, Mancusi A, Ruggeri L, Capanni M, Urbani E, Velardi A, Stern M The main functions of natural killer (NK) cells are early protection against viruses or tumor cells and production of cytokines that regulate immune functions. The present study assessed the role of different NK subsets in exerting graft-versus-leukemia effects in recipients of human leukocyte antigen (HLA) haploidentical hematopoietic transplants and monitored for the first time CD3-/CD56- lymphocyte expansion. CD3-/CD56- cells expressed NK cell-associated molecules, such as CD16, NKp46, NKp30, CD244 (2B4), CD161, and killer cell immunoglobulin-like receptors. CD3-/CD56- cells further exhibited the classical functional characteristics of NK cells: cytolysis of target cells lacking HLA class I, antibod... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4609534 Thu, 17 Mar 2011 00:00:00 +0100 4609534 http://www.medworm.com/index.php?rid=4609533&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411986%26dopt%3DAbstract Authors: Lee SE, Lim J, Yahng SA, Cho BS, Eom KS, Kim M, Kim YJ, Kim HJ, Min CK, Lee S, Kim DW, Lee JW, Min WS, Park CW, Cho SG Although reduced-intensity conditioning (RIC) has been increasingly used in patients with myelodysplastic syndrome (MDS) to reduce transplant-related mortality, a high relapse rate in RIC remains an unresolved problem. Considering the additive antileukemic effect of low-dose total body irradiation (TBI), we evaluated the feasibility of combining RIC regimens with low-dose TBI in de novo MDS. The RIC regimen combined with low-dose TBI in this study consisted of fludarabine (150 mg/m(2)), intravenous busulfan (6.4 mg/kg), and TBI (400 cGy). Antithymocyte globulin was used to overcome HLA mismatching. A total of 31 subjects were recruited with a median age of 39 ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4609533 Thu, 17 Mar 2011 00:00:00 +0100 4609533 http://www.medworm.com/index.php?rid=4609532&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411987%26dopt%3DAbstract Authors: Oyekunle A, Klyuchnikov E, Ocheni S, Kröger N, Zander AR, Baccarani M, Bacher U Following the introduction of the tyrosine kinase inhibitor (TKI) imatinib in the treatment of chronic myeloid leukemia (CML) patients, the allogeneic hematopoietic stem cell transplantation (HSCT) scene in CML has changed dramatically. The number of patients receiving HSCT in first chronic phase (CP) has declined rapidly, as allogeneic HSCT in CP is now performed in these patients only in case of failure or intolerance of TKIs. Second, those CML patients who undergo allogeneic HSCT represent a selection of high-risk patients due to more advanced disease with high rates of accelerated or blast phase (being associated with an increased relapse risk), advanced age and relevant co-morbidities. Effort... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4609532 Thu, 17 Mar 2011 00:00:00 +0100 4609532 http://www.medworm.com/index.php?rid=4609536&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21411983%26dopt%3DAbstract Authors: Girmenia C, Mercanti C, Federico V, Rea M, De Vellis A, Valle V, Micozzi A, Latagliata R, Breccia M, Morano SG, Brunetti GA, Sali M, Delogu G, Foà R, Alimena G, Gentile G Data derived from epidemiologic surveillance adopted at our center in hematologic and stem cell transplant patients during the 2009 influenza A (H1N1)v pandemic are reported. Of the 52 patients with influenza-like disease we observed, 37 underwent a real-time PCR evaluation and 21 had a confirmed diagnosis. Of the RT-PCR-confirmed cases, 23.8% were children (age <18 years) and 9.5% were >65 years; 47.6% presented with a pulmonary infiltrate and 33.3% with respiratory failure. Pulmonary involvement was observed more frequently in patients with comorbidities. All patients received a course of oseltamivir... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4609536 Fri, 11 Mar 2011 00:00:00 +0100 4609536 http://www.medworm.com/index.php?rid=4546354&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21335959%26dopt%3DAbstract Authors: Hattori N, Fukuchi K, Nakamaki T, Homma M, Ariizumi H, Nakashima H, Maeda T, Saito B, Yamochi-Onizuka T, Yanagisawa K, Matsuda I, Ota H, Tomoyasu S No abstract available. PMID: 21335959 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4546354 Fri, 18 Feb 2011 00:00:00 +0100 4546354 http://www.medworm.com/index.php?rid=4490968&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325812%26dopt%3DAbstract Conclusion: A high international prognostic index risk, neutropenic fever and a high cumulative dose of steroids appear to be risk factors for HVI in DLBL patients who are undergoing rituximab combined chemotherapy. PMID: 21325812 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4490968 Sat, 12 Feb 2011 00:00:00 +0100 4490968 http://www.medworm.com/index.php?rid=4490967&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21325813%26dopt%3DAbstract We report a 63-year-old female patient with AML, who showed a 3-way novel variant of t(8;21), t(1;21;8)(q21;q22;q22). She presented with gastric discomfort and splenomegaly, and her complete blood count was: white blood cell count 7.96 × 10(9)/l, with 7% blasts; hemoglobin 8.3 g/dl, and platelets 66 × 10(9)/l. Her bone marrow showed increased blasts (32.5%) with a basophilic cytoplasm, salmon-pink granules and Auer rods. Cytogenetic analysis revealed a karyotype of 46,XX,t(1;21;8)(q21;q22;q22), and fluorescence in situ hybridization confirmed a RUNX1-RUNX1T1 fusion signal on the derivative chromosome 8. After induction chemotherapy, the patient achieved complete remission and has been stable for 6 months. To the best of our knowledge, this is the first report on the novel variant of t(8;... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4490967 Sat, 12 Feb 2011 00:00:00 +0100 4490967 http://www.medworm.com/index.php?rid=4490969&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21282944%26dopt%3DAbstract Authors: Lorch D, Spevack D, Little J PMID: 21282944 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4490969 Tue, 01 Feb 2011 00:00:00 +0100 4490969 http://www.medworm.com/index.php?rid=4422613&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21273766%26dopt%3DAbstract In this report, we present a case of a spontaneous pregnancy in a 42-year-old thalassemic woman referred to our Microcythemic Unit while she was on deferasirox (DFX) therapy. The patient had been on treatment with DFX since March 2008 and in March 2009 realized that she was pregnant at 12 weeks of gestation. The conception was spontaneous and the baby was born at full term without complications or malformations. PMID: 21273766 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4422613 Thu, 27 Jan 2011 00:00:00 +0100 4422613 http://www.medworm.com/index.php?rid=4422615&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21266800%26dopt%3DAbstract Conclusions: Our findings indicate that BAL shows a high incidence of abnormal karyotypes and a poor prognosis. Combined-type regimens or ALL-based protocols are effective for the treatment of BAL. PMID: 21266800 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4422615 Tue, 25 Jan 2011 00:00:00 +0100 4422615 http://www.medworm.com/index.php?rid=4422614&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21266801%26dopt%3DAbstract Authors: Quarta A, Melpignano A, Quarta G Iron overload sometimes complicates the clinical course of bone marrow transplantation and can cause damage to liver and heart function. A patient with post-transplantation secondary hemochromatosis was treated with deferasirox, which not only normalized ferritin levels, but also reduced hepatic iron to normal values as measured by biosusceptometry with a superconducting quantum interference device. Side effects were minimal. The use of deferasirox to reduce post-transplant iron burden merits evaluation in a larger patient population. PMID: 21266801 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4422614 Tue, 25 Jan 2011 00:00:00 +0100 4422614 http://www.medworm.com/index.php?rid=4422620&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21252495%26dopt%3DAbstract Conclusion: Our report extends the list of known ALAS2 mutations, with the addition of a novel K156E substitution that is responsive to pyridoxine treatment and contributes to the general knowledge of congenital SA cases characterized worldwide. PMID: 21252495 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4422620 Thu, 20 Jan 2011 00:00:00 +0100 4422620 http://www.medworm.com/index.php?rid=4422618&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21252496%26dopt%3DAbstract This study presents 12 patients (7 women and 5 men) with vitamin B(12)-responsive pancytopenia who had discordant laboratory findings and were misdiagnosed as having myelodysplastic syndrome (MDS). The median hemoglobin level was 6.5 g/dl, and the leukocyte and platelet counts were 2.85 × 10(9)/l and 55.5 × 10(9)/l, respectively. The median serum lactate dehydrogenase level was high (3,204.5 IU/l). The serum vitamin B(12) levels were within normal limits at the initial evaluation, but a serial follow-up of the vitamin B(12) levels revealed either fluctuations or a gradual decrease. The patients were initially diagnosed with MDS and responded rapidly to a 7-day parenteral B(12) treatment with normal complete blood counts (CBCs). We propose that patients suspected to have MDS may suffer fr... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4422618 Thu, 20 Jan 2011 00:00:00 +0100 4422618 http://www.medworm.com/index.php?rid=4422617&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21252497%26dopt%3DAbstract Conclusions: Most CDA II patients in Israel are of Moroccan Jewish origin and carry a common SEC23B mutation, E109K, the first to be described as a founder mutation causing CDA II. As previously suggested, carrying 2 missense mutations is associated with a relatively nonsevere phenotype. PMID: 21252497 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4422617 Thu, 20 Jan 2011 00:00:00 +0100 4422617 http://www.medworm.com/index.php?rid=4422616&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21252498%26dopt%3DAbstract Authors: Kosus N, Kosus A, Yıldırım M, Duran M, Turhan NO No abstract available. PMID: 21252498 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4422616 Thu, 20 Jan 2011 00:00:00 +0100 4422616 http://www.medworm.com/index.php?rid=4359297&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21228565%26dopt%3DAbstract Authors: Pansuwan A, Fucharoen G, Fucharoen S, Himakhun B, Dangwiboon S The prevalence of adolescent anemia, iron deficiency and thalassemia were examined in 2 provinces of northeast Thailand. Blood specimens were collected from adolescent subjects aged 15-17 years in 2 areas; 185 (85 males and 100 females) in Mukdahan province and 313 (116 males and 197 females) in Roi-Et. RBC parameters, serum ferritin levels, Hb and DNA analyses for the identification of common thalassemia genes in Thailand were investigated. The prevalences of anemia were found to be 21.1% (8.1 in male and 13.0 in female) and 16.6% (8.9 in male and 7.7 in female) in Mukdahan and Roi-Et province, respectively. Iron deficiency was observed to be 24.3% in Mukdahan and 14.7% in Roi-Et. Various types of thalassemia were... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4359297 Thu, 13 Jan 2011 00:00:00 +0100 4359297 http://www.medworm.com/index.php?rid=4359298&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21212658%26dopt%3DAbstract Authors: Wu X, Liu W, Tian Y, Xiao M, Wu Y, Li C Death-associated protein kinase 1 (DAPK1), a proapoptotic serine/threonine kinase, is a candidate tumor suppressor gene. We studied the methylation status of the promoter region of the DAPK1 gene and the expression of the DAPK1 protein in 78 bone marrow samples from untreated patients with myelodysplastic syndrome (MDS) by PCR and Western blot analysis. Hypermethylation of DAPK1 was present in 42.3% (33 of 78) of MDS specimens and was significantly correlated with the loss of DAPK1 mRNA and protein expression (p < 0.01). There were no significant differences in methylation frequency among subgroup of MDS. DAPK1 hypermethylation in MDS was associated with the presence of cytogenetic abnormalities in the bone marrow at the time of the i... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4359298 Tue, 04 Jan 2011 00:00:00 +0100 4359298 http://www.medworm.com/index.php?rid=4259976&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150179%26dopt%3DAbstract Authors: Yang M, Wang FD, Han B, Wang SJ, Zhou DB, Pan H, Zhao YQ, Cui QC, Ma L, Chng WJ, Shen T No abstract available. PMID: 21150179 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259976 Wed, 15 Dec 2010 17:01:16 +0100 4259976 http://www.medworm.com/index.php?rid=4259968&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150182%26dopt%3DAbstract Authors: Raanani P, Skoetz N No abstract available. PMID: 21150182 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259968 Wed, 15 Dec 2010 17:00:31 +0100 4259968 http://www.medworm.com/index.php?rid=4259963&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150183%26dopt%3DAbstract The objective of this overview is to summarize all existing systematic reviews on treatments in multiple myeloma (MM), which accounts for 14% of new cases of hematological malignancies each year. Therefore, MEDLINE and the Cochrane Database of Systematic Reviews were systematically searched to identify systematic reviews of interventions. Data were extracted on patients, interventions, control and outcomes. Methodological quality of the systematic reviews was assessed using the AMSTAR assessment tool. Eleven systematic reviews on treatment of MM were included in the overview. Ten addressed seven unique questions and also performed a meta-analysis. One addressed 21 clinical questions related to treatment decisions in myeloma. The quality of systematic reviews varied. The results from the ov... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259963 Wed, 15 Dec 2010 17:00:12 +0100 4259963 http://www.medworm.com/index.php?rid=4259953&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150184%26dopt%3DAbstract Authors: Vidal L, Gafter-Gvili A, Shpilberg O The course of follicular lymphoma has changed considerably with the introduction of immunotherapy. Systematic reviews and meta-analyses are reliable, efficient and well-established methods to summarize the vast amount of data acquired in recent years on the role of immunotherapy, including monoclonal antibodies, radio-labeled monoclonal antibodies and interferon-α in the treatment of patients with follicular lymphoma. We aimed to summarize the data from systematic reviews assessing immunotherapy for these patients. A search through Medline and the Cochrane Library for systematic reviews of randomized controlled trials of different types of immunotherapy for patients with follicular lymphoma yielded 17 reviews. Eleven of them were eligible ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259953 Wed, 15 Dec 2010 16:59:44 +0100 4259953 http://www.medworm.com/index.php?rid=4259913&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150185%26dopt%3DAbstract Authors: Herbst C, Engert A Meta-analyses have followed some of the most important advances in the treatment of early-stage Hodgkin lymphoma (HL). In this review, details on all meta-analyses of patients with early-stage HL are discussed. In 1990, the first meta-analysis addressing patients with early-stage HL compared radiotherapy alone to combined-modality treatment (CMT). It was followed in 1998 by an individual-patient meta-analysis examining the role of radiotherapy with and without chemotherapy. In 2006, a comprehensive meta-analysis focusing on the risk of secondary malignancies, including most of the treatment regimens analyzed in clinical trials, was issued. The final analysis was published 2010 and provides important information for the ongoing discussion concerning the role ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259913 Wed, 15 Dec 2010 16:59:05 +0100 4259913 http://www.medworm.com/index.php?rid=4259894&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150186%26dopt%3DAbstract Authors: Ram R, Gafter-Gvili A, Shpilberg O, Raanani P In spite of decades of research in the field of allogeneic hematopoietic cell transplantation for the treatment of acute leukemia, controversies regarding the role of transplant still exist. These stem not only from contradictory results of different studies, but also from differences in the design and the strength of evidence of the various trials. Meta-analysis is considered the highest level of evidence and as such has the power to resolve clinical issues comparing between different treatment modalities. The aim of this review is to examine the contribution of meta-analyses to the establishment of the role of hematopoietic transplantation for acute leukemia and at the same time to highlight limitations and future directions. ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259894 Wed, 15 Dec 2010 16:58:21 +0100 4259894 http://www.medworm.com/index.php?rid=4259864&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150187%26dopt%3DAbstract The objective of this review is to assess the base of evidence for the common practice and the current guidelines for the management of aplastic anemia. It focuses on data obtained from systematic reviews and meta-analyses of RCTs conducted in this field. Specifically, it focuses on four major therapeutic questions: the roles of alloHCT, IST, hematopoietic growth factors and supportive care. PMID: 21150187 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259864 Wed, 15 Dec 2010 16:56:25 +0100 4259864 http://www.medworm.com/index.php?rid=4259842&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150188%26dopt%3DAbstract Authors: Bohlius J, Tonia T, Schwarzer G Anemia associated with cancer and cancer therapy is a common and important issue in the treatment of patients with malignant disease. Conventionally, blood transfusions are used to treat severe cancer-related anemia. Short- and long-acting preparations of recombinant human erythropoiesis-stimulating agents (ESAs) offer an alternative treatment option. Multiple studies and subsequent meta-analyses have demonstrated that ESA treatment increases hemoglobin levels and reduces the likelihood of transfusion for a proportion of treated patients. However, studies that attempted to evaluate whether ESAs improve tumor response and survival have generated conflicting evidence. Results of smaller trials reporting improved survival outcomes were contradicted... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259842 Wed, 15 Dec 2010 16:53:22 +0100 4259842 http://www.medworm.com/index.php?rid=4259765&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150189%26dopt%3DAbstract Authors: Gurion R, Shacham-Abulafia A, Shpilberg O, Raanani P Myeloid colony-stimulating factors (M-CSFs), which include granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), regulate the proliferation and differentiation of myeloid cells. Their use has an important role in the treatment of hematologic malignancies. Guidelines for the use of colony stimulating factors have been published by the American Society of Oncology (ASCO) in 1996 and have been updated several times, most recently in 2006. Meta-analyses of randomized controlled trials are regarded as the highest grade of evidence in clinical research and as such, compared to individual studies, they have more power in answering unresolved clinical issues. In this review, our... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259765 Wed, 15 Dec 2010 15:58:57 +0100 4259765 http://www.medworm.com/index.php?rid=4259725&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150190%26dopt%3DAbstract Authors: Paul M, Gafter-Gvili A, Goldberg E, Yahav D Systematic reviews and meta-analyses have made a major contribution to the evidence-based management of infections in cancer patients. We review the contribution of systematic reviews with regard to antibiotic, antifungal, antiviral and Pneumocystis pneumonia prophylaxis; antibiotic and antifungal treatment of febrile neutropenia; use of intravenous immunoglobulins, and infection control strategies during neutropenia. We focus on limitations of randomized controlled trials and the way systematic reviews have addressed and resolved some of these limitations. Systematic reviews allow us to ask the right clinical question; consider the most relevant clinical outcome; address the problem of small trials and rare outcomes; address externa... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259725 Wed, 15 Dec 2010 14:49:57 +0100 4259725 http://www.medworm.com/index.php?rid=4259682&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150191%26dopt%3DAbstract Authors: Gale RP, Lazarus HM Meta-analyses of data from randomized clinical trials (RCTs) are often used by hematologists to compare the efficacy of therapies of blood diseases. This is especially so when results of RCTs are not decisive. This situation in RCTs arises when the magnitude of differences in treatment outcomes between therapies tested is small, when trials are unpowered to detect differences (these are confounded) and/or when RCTs reach, or seem to reach, contradictory conclusions. Contributing to these limitations of RCTs are the relative rarity of many blood diseases, poor recruitment into RCTs and the greater interest of many hematologists in therapy strategy than in a direct comparison of alternate therapies. These limitations of RCTs are solvable, but only in part, by... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259682 Wed, 15 Dec 2010 13:57:06 +0100 4259682 http://www.medworm.com/index.php?rid=4259973&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150180%26dopt%3DAbstract In conclusion, severe endothelial dysfunction is present during the acute phase of ALL and during treatment and appears to result from the disease itself. Serum TM and vWF levels might represent additional, but not independent, prognostic markers in childhood ALL. PMID: 21150180 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259973 Sat, 11 Dec 2010 00:00:00 +0100 4259973 http://www.medworm.com/index.php?rid=4259970&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150181%26dopt%3DAbstract Authors: D'Alcamo E, Agrigento V, Sclafani S, Vitrano A, Cuccia L, Maggio A, Perrotta S, Capra M, Rigano P No abstract available. PMID: 21150181 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259970 Sat, 11 Dec 2010 00:00:00 +0100 4259970 http://www.medworm.com/index.php?rid=4259978&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21150178%26dopt%3DAbstract Authors: Kim MG, Park SY, Kim EJ, Kim YM, Kim HY, Lee YK, Zang DY, Kim HJ A 69-year-old woman with relapsed primary central nervous system (CNS) lymphoma was treated with intrathecal rituximab without a concomitant systemic steroid or other chemotherapeutic drugs. Her initial viral status was HBs Ag negative and anti-HBs Ab positive. After 12 weeks of the last intrathecal rituximab application, the levels of AST and ALT were 1,005 and 1,134 IU/l, respectively. The viral status was changed as follows: HBs Ag positive, anti-HBs Ab negative, anti-HBe Ag positive, and anti-HBe Ab negative. The titer of hepatitis B virus (HBV) DNA was 106,000 IU/ml. She was diagnosed with acute hepatitis due to HBV reactivation. To our knowledge, this is the first reported case of HBV reactivation occurring... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4259978 Wed, 08 Dec 2010 00:00:00 +0100 4259978 http://www.medworm.com/index.php?rid=4205685&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21109732%26dopt%3DAbstract Conclusion: Our results provide evidence for a significant association between the factor V mutation and placental abruption. Furthermore, we found that this and the non-O blood group independently increased the risk for intra-uterine growth retardation in our population. PMID: 21109732 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4205685 Sat, 27 Nov 2010 00:00:00 +0100 4205685 http://www.medworm.com/index.php?rid=4205686&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21109731%26dopt%3DAbstract Conclusion: Despite routine administration of pegfilgrastim with CHOP chemotherapy, a high proportion of patients experienced FN after chemotherapy. Identifying patients at risk for breakthrough FN events may allow the optimization of myeloid growth factor usage among lymphoma patients receiving chemotherapy. PMID: 21109731 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4205686 Thu, 25 Nov 2010 00:00:00 +0100 4205686 http://www.medworm.com/index.php?rid=4205687&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21099215%26dopt%3DAbstract Authors: Savage WJ, Everett AD, Casella JF A 12-year-old boy with HbSS sickle cell disease (SCD) was admitted with an acute febrile illness and developed overt stroke 3 days later. Plasma glial fibrillary acidic protein levels were elevated, as compared to pediatric controls, 32 h prior to the clinical diagnosis of stroke, peaked immediately prior to the exchange transfusion, and remained elevated 1 year later despite chronic transfusion therapy. Stroke in SCD can occur in the setting of acute illness, and a biomarker that could predict the onset and triage ill children to therapeutic intervention more quickly would be useful. PMID: 21099215 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4205687 Wed, 24 Nov 2010 00:00:00 +0100 4205687 http://www.medworm.com/index.php?rid=4205691&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21099211%26dopt%3DAbstract Authors: Girolami A, Berti de Marinis G, Bonamigo E, Sartori R, Vettore S Factor VII (FVII) deficiency, the most frequent defect among the rare bleeding disorders, is commonly divided into type I and type II. In the former, there is a concomitant decrease in FVII activity and antigen. In the latter, there is a clear discrepancy between activity which is low and antigen which is normal or nearly normal. FVII Padua (Arg304Gln) is characterized by different reactivity towards different tissue thromboplastins. FVII levels were assayed by the use of different tissue thromboplastins, namely rabbit brain, human placenta, human recombinant and ox brain thromboplastin, in 6 homozygous patients. Cases reported in the literature were also evaluated. Ox brain thromboplastins yielded normal values,... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4205691 Sat, 20 Nov 2010 00:00:00 +0100 4205691 http://www.medworm.com/index.php?rid=4205690&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21099212%26dopt%3DAbstract We report the case of a 26-year-old man with testicular cancer who was extensively pretreated and failed to mobilize a sufficient number of HPSCs after cytotoxic chemotherapy and the administration of G-CSF and pegylated G-CSF (PEG-G-CSF). Using a combination of plerixafor, G-CSF and PEG-G-GSF after chemotherapy, a sufficient number of HPSCs could be collected for the support of 3 sequential high-dose therapies. The patient achieved a complete and uncomplicated engraftment following each cycle of HPSC-supported high-dose therapy. Patients suffering from advanced germ cell cancer may be another group that benefits from the use of plerixafor, which to date has only been approved for the treatment of multiple myeloma and lymphoma. To our knowledge, this is the first case report of successful ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4205690 Sat, 20 Nov 2010 00:00:00 +0100 4205690 http://www.medworm.com/index.php?rid=4205689&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21099213%26dopt%3DAbstract Conclusions: PTCL with BMI have a similar aggressive course and poor survival compared to DLBCL with BMI. Thus, the immunophenotype of either T or B lineage may not be a crucial prognostic indicator of survival for these 2 aggressive lymphomas. PMID: 21099213 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4205689 Sat, 20 Nov 2010 00:00:00 +0100 4205689 http://www.medworm.com/index.php?rid=4205688&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21099214%26dopt%3DAbstract Conclusion: p-ALG plus CsA is a reliable and well-tolerated treatment for SAA, and it has the great advantage of a much lower cost compared to horse/rabbit ATG. VSAA was a poor predictive factor for the response rate. PMID: 21099214 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4205688 Sat, 20 Nov 2010 00:00:00 +0100 4205688 http://www.medworm.com/index.php?rid=4173367&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21071931%26dopt%3DAbstract Authors: Kamiya S, Hagimori M, Ogasawara M, Arakawa M Thrombosis is characterized by congenital and acquired procatarxis. Nattokinase inhibits thrombus formation in vitro. However, in vivo evaluation of the therapeutic efficacy of nattokinase against thrombosis remains to be conducted. Subcutaneous nattokinase injections of 1 or 2 mg/ml were administered to the tails of rats. Subsequently, κ-carrageenan was intravenously administered to the tails at 12 h after nattokinase injections. The mean length of the infarcted regions in the tails of rats was significantly shorter in rats administered 2 mg/ml of nattokinase than those in control rats. Nattokinase exhibited significant prophylactic antithrombotic effects. Previously, the in vitro efficacy of nattokinase against thrombosis had bee... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4173367 Sat, 13 Nov 2010 00:00:00 +0100 4173367 http://www.medworm.com/index.php?rid=4173366&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21071932%26dopt%3DAbstract Authors: Bernardeschi P, Pirrotta MT No abstract available. PMID: 21071932 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4173366 Sat, 13 Nov 2010 00:00:00 +0100 4173366 http://www.medworm.com/index.php?rid=4173370&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21071928%26dopt%3DAbstract Authors: Santos PC, Cançado RD, Pereira AC, Chiattone CS, Krieger JE, Guerra-Shinohara EM No abstract available. PMID: 21071928 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4173370 Fri, 12 Nov 2010 00:00:00 +0100 4173370 http://www.medworm.com/index.php?rid=4173369&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21071929%26dopt%3DAbstract Authors: Lewis G, Hall P, Eisa N, Deremer D, Dobbins R, El-Geneidy M, Jillella A, Ustun C We evaluated the frequency of invasive fungal infections (IFI), the frequency of empirical antifungal use (EAFU), and the efficacy of fluconazole prophylaxis on IFI and EAFU after high-dose cytarabine (HiDAC) consolidations. Twenty-seven acute myelogenous leukemia patients in their first complete remission received 76 cycles of HiDAC (median cycle: n = 3). Fluconazole prophylaxis was administered following 44 cycles (fluconazole group) and not given in 32 cycles (control group). IFI (2 episodes) + EAFU (11 episodes) was observed in 13 of 76 cycles (17%); there was no difference between the fluconazole group and the control group (p = 0.469). Neutropenia duration was <13 days in 89% of the 76 cy... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4173369 Fri, 12 Nov 2010 00:00:00 +0100 4173369 http://www.medworm.com/index.php?rid=4173368&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21071930%26dopt%3DAbstract Authors: Gary T, Hafner F, Froehlich H, Stojakovic T, Scharnagl H, Pilger E, Brodmann M No abstract available. PMID: 21071930 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4173368 Fri, 12 Nov 2010 00:00:00 +0100 4173368 http://www.medworm.com/index.php?rid=4125991&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042009%26dopt%3DAbstract Conclusions: Serum leptin is low in beta-thalassaemia, perhaps due to the toxic effect of iron overload on adipose tissue. Paradoxically, adiponectin levels are high and positively correlated with endothelin-1, raising questions about the pro- or anti-inflammatory role of this adipocytokine in beta-thalassaemia. PMID: 21042009 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4125991 Tue, 02 Nov 2010 00:00:00 +0100 4125991 http://www.medworm.com/index.php?rid=4125990&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042010%26dopt%3DAbstract We report a case of severe hemolytic anemia induced by cefoxitin in a 45-year-old woman admitted with menometrorrhagia. Hemoglobin levels reached a nadir of 4.7 g/dl approximately 72 h after cefoxitin initiation, and hemolysis resolved when cefoxitin was discontinued and prednisone 1 mg/kg was initiated. A transfusion reaction workup revealed no abnormalities. Direct antiglobulin testing was weakly positive with anti-C3. The patient's plasma and RBC eluate reacted with cefoxitin-treated RBCs but not with untreated RBCs in the presence or absence of cefoxitin. PMID: 21042010 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4125990 Tue, 02 Nov 2010 00:00:00 +0100 4125990 http://www.medworm.com/index.php?rid=4125989&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21042011%26dopt%3DAbstract We describe the successful treatment of a 21-year-old male with DC by nonmyeloablative HSCT from a matched unrelated donor. The gene responsible for the X-linked form of DC was screened and hemizygosity for the mutation Gln31Lys was found, which is consistent with the diagnosis. The conditioning regimen consisted of only fludarabine and antithymocyte globulin. Additionally, a graft-versus-host disease (GVHD) prophylaxis was administered with cyclosporine A (CSA) and mycophenolate mofetil (MMF). The regimen was well tolerated, no severe posttransplantation complications were observed, and engraftment was rapid and complete (granulocytes on day +11 and platelets on day +13). Seven months after HSCT, the patient developed GVHD of the liver after tapering CSA which was successfully treated wit... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4125989 Tue, 02 Nov 2010 00:00:00 +0100 4125989 http://www.medworm.com/index.php?rid=4098883&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20962520%26dopt%3DAbstract Authors: Kaloyannidis P, Papalexandri A, Papaemanouil E, Papaioannou M, Sakellari I No abstract available. PMID: 20962520 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4098883 Wed, 20 Oct 2010 23:00:00 +0100 4098883 http://www.medworm.com/index.php?rid=4098882&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20962521%26dopt%3DAbstract Authors: Romo Martinez EJ, Vasquez Jimenez EA, Barajas Torres RL, Delgado Lamas JL, Magaña Torres MT, Gonzalez Garcia JR No abstract available. PMID: 20962521 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4098882 Wed, 20 Oct 2010 23:00:00 +0100 4098882 http://www.medworm.com/index.php?rid=4098885&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20962518%26dopt%3DAbstract Authors: Lipshitz J, Limaye S, Patel D No abstract available. PMID: 20962518 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4098885 Tue, 19 Oct 2010 23:00:00 +0100 4098885 http://www.medworm.com/index.php?rid=4098884&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20962519%26dopt%3DAbstract Authors: Yamaguti GG, Lourenço GJ, Silveira VS, Tone LG, Lopes LF, Lima CS No abstract available. PMID: 20962519 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4098884 Tue, 19 Oct 2010 23:00:00 +0100 4098884 http://www.medworm.com/index.php?rid=4098886&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20948190%26dopt%3DAbstract Authors: Tadmor T, Rimar D, Rozenbaum M, Vadasz Z, Attias D No abstract available. PMID: 20948190 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4098886 Thu, 14 Oct 2010 23:00:00 +0100 4098886 http://www.medworm.com/index.php?rid=4067101&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20938171%26dopt%3DAbstract Authors: McCarthy N, McCarron SL, Langabeer SE No abstract available. PMID: 20938171 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4067101 Tue, 12 Oct 2010 23:00:00 +0100 4067101 http://www.medworm.com/index.php?rid=4067099&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20938173%26dopt%3DAbstract Authors: Koh H, Nakamae H, Koh KR, Ohsawa M, Nakane T, Takeoka Y, Aimoto R, Aimoto M, Wada-Inoue E, Terada Y, Yamane T, Hino M A 59-year-old man with lymphoma-type adult T-cell leukemia/lymphoma was admitted to hospital for treatment of a skin relapse on day 398 after allogeneic hematopoietic stem cell transplantation (allo-HSCT). To induce a graft-versus-adult T-cell leukemia/lymphoma effect, we discontinued methylprednisolone and tacrolimus. About a month after the discontinuation, he developed grade II acute graft-versus-host disease (GVHD) with a high fever. Soon after the development of GVHD, all the skin lesions regressed in size and finally vanished. However, he developed diffuse alveolar hemorrhage (DAH), which was resistant to high-dose corticosteroid therapy. He was intubated... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4067099 Tue, 12 Oct 2010 23:00:00 +0100 4067099 http://www.medworm.com/index.php?rid=4067100&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20938172%26dopt%3DAbstract Conclusions: The prevalence of β(S)-haplotypes in this study is in agreement with the historical records of African slaves brought to the state of Minas Gerais. Furthermore, β(S)-haplotypes CAR and Ben were not associated with any analyzed feature of children with sickle cell anemia. PMID: 20938172 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4067100 Mon, 11 Oct 2010 23:00:00 +0100 4067100 http://www.medworm.com/index.php?rid=4067104&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20938168%26dopt%3DAbstract Conclusion: Although there is no evidence for a causal relationship between Hp-I and MDS, the increased prevalence of Hp-I among the MDS patients is an interesting finding that deserves further investigation as it may indicate a common factor causing susceptibilities to both MDS and Hp-I or that Hp might influence the pathophysiology of MDS. PMID: 20938168 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4067104 Sun, 10 Oct 2010 23:00:00 +0100 4067104 http://www.medworm.com/index.php?rid=4067103&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20938169%26dopt%3DAbstract Authors: Breccia M, Capria S, Iori AP, Foà R, Alimena G, Meloni G No abstract available. PMID: 20938169 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4067103 Sun, 10 Oct 2010 23:00:00 +0100 4067103 http://www.medworm.com/index.php?rid=4067102&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20938170%26dopt%3DAbstract Authors: Schroeder T, Zohren F, Saure C, Bruns I, Czibere A, Safaian NN, Fenk R, Haas R, Kobbe G No abstract available. PMID: 20938170 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4067102 Sun, 10 Oct 2010 23:00:00 +0100 4067102 http://www.medworm.com/index.php?rid=4031555&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20881379%26dopt%3DAbstract Authors: Zhao J, Luo Y, Wang X, Zhou H, Li Q, You Y, Zou P Direct interaction between T-suppressor and dendritic cells (DCs) results in DC tolerance by inducing upregulation of immunoglobulin-like transcript (ILT) 3 and ILT4. DCs were treated with a lentiviral vector containing paired immunoglobulin-like B gene (PIR-B) DCs and the effect of PIR-B-DCs on graft-versus-host disease (GVHD) was analyzed after allogeneic bone marrow (BM) transplantation (BMT). Therefore, 1 × 10(6) recipient-derived PIR-B-DCs were injected into BALB/c (H-2k(d)) mice using BM-splenocyte grafts from major histocompatibility complex-disparate C57BL/6 (H-2k(b)). Our results showed that PIR-B-DCs deficient in surface costimulatory molecules had higher PIR-B protein expression than immature DCs and interleukin 10-... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4031555 Tue, 28 Sep 2010 23:00:00 +0100 4031555 http://www.medworm.com/index.php?rid=4031556&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20881378%26dopt%3DAbstract Authors: Henry J, Casjens S, Schikowski T, Stachon A, Germing A, Ranft U, Lehnert M, Harth V, Krämer U, Brüning T, Pesch B No abstract available. PMID: 20881378 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4031556 Mon, 27 Sep 2010 23:00:00 +0100 4031556 http://www.medworm.com/index.php?rid=4017918&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20861612%26dopt%3DAbstract We report the case of a 14-year-old African-American boy who was diagnosed with sickle cell disease. Laboratory tests showed that the patient was a compound heterozygote for a novel Hb variant with a double mutation detected on β(S) allele, Hb S βGlu6Val, and βAsn139Ser substitution, i.e. a β-chain variant named 'Hb S-Wake'. The patient also carried a single Hb S mutation in trans allele, leading to Hb SS-Wake disease. He had coinherited homozygous α(+)-thalassemia (-α(3.7)/-α(3.7)) simultaneously which resulted in multiple globin gene abnormalities. PMID: 20861612 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4017918 Wed, 22 Sep 2010 23:00:00 +0100 4017918 http://www.medworm.com/index.php?rid=4017917&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20861613%26dopt%3DAbstract Authors: Faulhaber GA, Furlanetto TW, Astigarraga CC, Moser Filho HL, Paludo AP, Silla LM New indications and conditioning regimens for hematopoietic stem cell transplantation (HSCT) have emerged in the last 10 years. Previous studies have shown the association of HSCT with late effects such as sleep disorders. The aim of this study was to determine the prevalence and factors associated with sleep disorders following HSCT in a population considering these new trends. Sixty-one individuals 1-10 years after allogeneic HSCT were surveyed using the DSM-IV-TR criteria for sleep disorders. Factors related to conditioning and graft-versus-host disease were collected from medical records. A prevalence of sleep disorders of 26.2% was found. Busulfan-cyclophosphamide conditioning was an independ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=4017917 Wed, 22 Sep 2010 23:00:00 +0100 4017917 http://www.medworm.com/index.php?rid=3958865&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20798489%26dopt%3DAbstract This report confirms the importance of both Hb and molecular investigations for the assessment of genotype/phenotype correlation and the appropriate management of the patients. PMID: 20798489 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=3958865 Wed, 25 Aug 2010 23:00:00 +0100 3958865 http://www.medworm.com/index.php?rid=3903999&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20733288%26dopt%3DAbstract Authors: Schröttner P, Wollner S, Catusse J, Burger M No abstract available. PMID: 20733288 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=3903999 Mon, 23 Aug 2010 23:00:00 +0100 3903999 http://www.medworm.com/index.php?rid=3887223&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20720403%26dopt%3DAbstract Authors: Serpa M, Bendit I, Seguro F, Xavier F, Cavalcante M, Steinbaum D, Nardinelli L, Aldred VL, de Paula HM, Dorlhiac-Llacer PE While chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) are common diseases in the elderly, they rarely occur simultaneously in the same patient. Here we present the case of a 77-year-old patient diagnosed with CML in the chronic phase who showed an optimal response to 400 mg/day of imatinib. This patient progressed to Binet B-CLL with an 11q22.3 deletion and CD38 positivity in the 4th month of treatment. During the follow-up, his lymphocyte number doubled in <6 months. Based on previous reports, dasatinib was chosen instead of imatinib. After 6 months of treatment with 100 mg/day of dasatinib, the patient demonstrated a partial resp... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=3887223 Wed, 18 Aug 2010 23:00:00 +0100 3887223 http://www.medworm.com/index.php?rid=3845580&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689269%26dopt%3DAbstract Authors: Ojeda-Uribe M, Herbrecht R, Kiefer MH, Schultz P, Chain J, Chenard MP, Servant JM, Debry C A rare case of oromandibular Rhizopus oryzae infection is described in a 55-year-old woman with acute myeloid leukaemia and decompensated diabetes mellitus. The infection developed during induction chemotherapy when the patient was neutropenic. She was treated with a combination of amphotericin B lipid formulation and caspofungin plus surgery. Debridement surgery included excision of the lower lip, chin, floor of the mouth, a portion of the tongue, as well as mandibular resection at the level of the horizontal branches. Eight weeks of combined antifungal therapy were followed by secondary prophylaxis with amphotericin B lipid formulation during consolidation chemotherapy after achieving ... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=3845580 Mon, 02 Aug 2010 23:00:00 +0100 3845580 http://www.medworm.com/index.php?rid=3845579&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689270%26dopt%3DAbstract Authors: Stagno F, Vigneri P, Del Fabro V, Fidilio A, Spina P, Massimino M, Messina A, Di Raimondo F PMID: 20689270 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=3845579 Mon, 02 Aug 2010 23:00:00 +0100 3845579 http://www.medworm.com/index.php?rid=3798949&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20664196%26dopt%3DAbstract Conclusion: Micafungin has an excellent efficacy (61.7%) and safety profile when used as an empirical antifungal agent in febrile neutropenic patients with hematological disorders. PMID: 20664196 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=3798949 Tue, 20 Jul 2010 23:00:00 +0100 3798949 http://www.medworm.com/index.php?rid=3768105&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20639624%26dopt%3DAbstract We examined the apoptosis of circulating endothelial progenitor cells in MM subjects before and after BP treatment and in osteonecrosis patients using a flow-cytometric analysis. Our data showed an increase in endothelial cell apoptosis in MM patients after BP administration and in osteonecrosis subjects. Our study seems in agreement with the hypothesis that BPs can inhibit angiogenesis interfering with endothelial cell proliferation and survival, leading to loss of blood vessels and avascular necrosis. PMID: 20639624 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=3768105 Wed, 14 Jul 2010 23:00:00 +0100 3768105 http://www.medworm.com/index.php?rid=3768104&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20639625%26dopt%3DAbstract Authors: Yin XL, Zhang XH, Zhou TH, Zhang TL, Luo RG, Wang L, Zhou YL, Chen YS, Kong XJ, Liang B, He YY, Peng L, Lu LB, Fang SP, Wu ZK The clinical characteristics of 357 patients with hemoglobin H (HbH) disease from the Guangxi province of Southern China were studied. One hundred and ninety-one (53.3%) patients were diagnosed with HbH-Constant Spring, 19 were diagnosed with HbH Westmead. Ten patients were shown to have coinherited HbH-Constant Spring/QS with a beta-thalassemia mutation. Coinheritance of the beta-thalassemia gene does not alleviate anemia (8.2 +/- 2.3 vs. 7.6 +/- 1.7 g/dl, p = 0.276), or influence age at diagnosis (20.2 +/- 19.6 vs. 12.9 +/- 11.0 years, p = 0.276). Ferritin levels were significantly higher in the group of patients with the nondeletional form of the dis... Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=3768104 Wed, 14 Jul 2010 23:00:00 +0100 3768104 http://www.medworm.com/index.php?rid=3762576&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20628241%26dopt%3DAbstract Conclusion: The results indicated that hTERT siRNA resulted in 97.2 +/- 0.6% downregulation of the hTERT mRNA content; inhibition of the cell proliferation rate was about 52.8 +/- 2.3% and the apoptotic index of cells was 30.5 +/- 1.5%. hTERT plays an essential role in cell proliferation and control of the viability of leukemic cells, thus promising the development of drugs for leukemia. PMID: 20628241 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=3762576 Tue, 13 Jul 2010 23:00:00 +0100 3762576 http://www.medworm.com/index.php?rid=3743990&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20616541%26dopt%3DAbstract Conclusion: Our results support the conclusion that autologous SCT should not be considered as the first-line post-remission therapy for AML patients in CR1. PMID: 20616541 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=3743990 Fri, 09 Jul 2010 23:00:00 +0100 3743990 http://www.medworm.com/index.php?rid=3743993&cid=s_33499_19_f&fid=33499&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20616538%26dopt%3DAbstract Authors: Breccia M, Loglisci G, Salaroli A, Cannella L, Santopietro M, Alimena G No abstract available. PMID: 20616538 [PubMed - as supplied by publisher] (Source: Acta Haematologica) Acta Haematologica journals http://www.medworm.com/rss/comments.php?id=3743993 Thu, 08 Jul 2010 23:00:00 +0100 3743993