MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Acta Neurologica Scandinavica' source. Wed, 08 Feb 2012 20:42:54 +0100 http://www.medworm.com/index.php?rid=5668635&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01585.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5668635 Thu, 09 Feb 2012 00:47:07 +0100 5668635 http://www.medworm.com/index.php?rid=5668633&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2012.01651.x ConclusionsTorsions and deviations are strongly dependent. This result should allow the generation of a more transparent pathophysiological model. From a practical point of view, measurements of deviation appeared more robust than those of torsion. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5668633 Thu, 09 Feb 2012 00:45:00 +0100 5668633 http://www.medworm.com/index.php?rid=5668634&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2012.01643.x ConclusionUA levels are associated with clinical disease status in patients with NMO. Further investigations are recommended to elucidate the role of UA as a biomarker of disease activity in NMO. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5668634 Mon, 06 Feb 2012 05:00:00 +0100 5668634 http://www.medworm.com/index.php?rid=5649952&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2012.01646.x ConclusionsOur experience encourages application of intravenous thrombolytic treatment (especially when supported with multimodality neuroimaging) in patients with homonymous hemianopia, for which rehabilitation options are limited. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5649952 Wed, 01 Feb 2012 05:00:00 +0100 5649952 http://www.medworm.com/index.php?rid=5649954&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01639.x DiscussionSeveral factors were associated with prevalent epilepsy, with Ag‐ELISA suggesting the presence of neurocysticercosis. The association between epilepsy and some occupations may reflect differences in local attitudes toward epilepsy and should be further explored. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5649954 Tue, 31 Jan 2012 05:00:00 +0100 5649954 http://www.medworm.com/index.php?rid=5649953&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2012.01644.x ConclusionThe counting‐backward test is useful for evaluating executive dysfunction in INPH and for differentiating between INPH and AD patients. In particular, the first‐error score may reflect deficits in the response suppression related to executive dysfunction in INPH. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5649953 Tue, 31 Jan 2012 05:00:00 +0100 5649953 http://www.medworm.com/index.php?rid=5599254&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01559.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5599254 Wed, 18 Jan 2012 01:34:01 +0100 5599254 http://www.medworm.com/index.php?rid=5599253&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01638.x The extent and depth of traumatic brain injury (TBI) remains a major determining factor together with the type of structural insult and its location, whether mild, moderate or severe, as well as the distribution and magnitude of inflammation and loss of cerebrovascular integrity, and the eventual efficacy of intervention. The influence of exercise intervention in TBI is multiple, ranging from anti‐apoptotic effects to the augmentation of neuroplasticity. Physical exercise diminishes cerebral inflammation by elevating factors and agents involved in immunomodulatory function, and buttresses glial cell, cerebrovascular, and blood–brain barrier intactness. It provides unique non‐pharmacologic intervention that incorporate different physical activity regimes, whether dynamic or static, en... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5599253 Wed, 18 Jan 2012 01:31:43 +0100 5599253 http://www.medworm.com/index.php?rid=5561929&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01635.x ConclusionAs opposed to RRMS, patients with CIS did not show T2′ alterations compared to HC. However, the association between the T2LV and higher T2′ values suggests that T2′ reflects disease evolution. In CIS metabolic changes might be masked by compensatory mechanisms and become overt when disease progresses as has been shown for RRMS patients. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5561929 Tue, 03 Jan 2012 05:00:00 +0100 5561929 http://www.medworm.com/index.php?rid=5561928&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01634.x ConclusionsThe primary finding was a moderate reduction in physical activity among those with MS, but the magnitude was substantially smaller than reported in a published meta‐analysis. Importantly, the degree of physical inactivity can likely be overcome through the delivery of behavioral interventions for increasing physical activity and this should translate into meaningful consequences for persons with MS. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5561928 Tue, 03 Jan 2012 05:00:00 +0100 5561928 http://www.medworm.com/index.php?rid=5561927&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01633.x ConclusionsExternal anal sphincter electromyography examination cannot separate the different parkinsonian subgroups from each other in early course of the diseases. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5561927 Tue, 03 Jan 2012 05:00:00 +0100 5561927 http://www.medworm.com/index.php?rid=5561926&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01628.x ConclusionsThis is the first Scandinavian family carrying the P102L mutation in the PRNP gene. Gerstmann–Sträussler–Scheinker syndrome should be considered in the differential diagnosis when handling with patients with ataxia and/or dementia of unclear aetiology. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5561926 Sun, 01 Jan 2012 05:00:00 +0100 5561926 http://www.medworm.com/index.php?rid=5545578&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01630.x ConclusionOur case shows that flow cytometry of the CSF in addition to conventional CSF cytology has the potential to accelerate diagnosis of lymphomeningeal infiltration of B‐cell lymphoma. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5545578 Wed, 28 Dec 2011 16:57:23 +0100 5545578 http://www.medworm.com/index.php?rid=5526902&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01564.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5526902 Thu, 22 Dec 2011 13:06:07 +0100 5526902 http://www.medworm.com/index.php?rid=5526901&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01567.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5526901 Thu, 22 Dec 2011 13:06:05 +0100 5526901 http://www.medworm.com/index.php?rid=5488374&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01627.x Conclusions –  Seizure deterioration during pregnancy may be prevented or reduced by closely and systematically following our proposed algorithm. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5488374 Fri, 09 Dec 2011 05:00:00 +0100 5488374 http://www.medworm.com/index.php?rid=5506694&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01629.x ConclusionsEpidemiological studies play a key role in identifying genetic and environmental factors that are associated with complex diseases like MS. Methodological issues arise in every study, and investigators need to be able to detect, respond to and correct problems in a timely and scientifically valid manner. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5506694 Thu, 01 Dec 2011 05:00:00 +0100 5506694 http://www.medworm.com/index.php?rid=5488373&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01625.x Conclusions –  CSA is the specific respiratory event associated with stroke in the elderly. Additionally, CSA could be a marker of silent brain ischemia, as a sign of disturbed regulation of central respiratory mechanisms, tentatively of ischemic origin. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5488373 Thu, 01 Dec 2011 05:00:00 +0100 5488373 http://www.medworm.com/index.php?rid=5442919&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01626.x Conclusions –  HRV indices are candidates for early markers of developing post‐stroke infections, preceding routine blood samples. Thus, HRV‐based early diagnosis of post‐stroke infection should be investigated in more detail as it may have implications as a novel tool for timely and appropriate treatment. A corresponding continuous HRV‐based risk assessment using the ECG provided by the routine stroke monitoring system would be possible without any additional burden for patients and staff. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5442919 Fri, 25 Nov 2011 13:05:43 +0100 5442919 http://www.medworm.com/index.php?rid=5442921&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01621.x Conclusions –  The findings in this family further demonstrate genetic heterogeneity in familial autosomal dominant late‐onset PD. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5442921 Wed, 23 Nov 2011 05:00:00 +0100 5442921 http://www.medworm.com/index.php?rid=5442920&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01622.x Conclusions –  After 12 and 24 months of therapy, natalizumab was more effective than IFN beta 1a SC on both disease activity and disability progression. Prospective head‐to‐head studies would be helpful to further evaluate the differences observed in the MRI outcomes. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5442920 Wed, 23 Nov 2011 05:00:00 +0100 5442920 http://www.medworm.com/index.php?rid=5432823&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01623.x Conclusions –  The results show chronic MT elevation in a sample of subjects with symptomatic or recovered mTBI. This suggests that mTBI may be compensated, although not fully recovered, years after the injury. While the cause for MT elevation cannot be concluded from these preliminary observations, possible explanations include decreased cortical excitability and impaired subcortical conduction. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5432823 Tue, 22 Nov 2011 13:01:41 +0100 5432823 http://www.medworm.com/index.php?rid=5423674&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01624.x Conclusions –  Some HDLS cases were misdiagnosed with unspecified psychiatric diagnoses in affected relatives from the original 1984 publication. However, HDLS is an encephalopathy dominated by a frontal lobe syndrome with an inexorably progressive and fatal course, where the different symptomatology in two recent cases confirmed the existence of acute and chronic variants. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5423674 Sat, 19 Nov 2011 13:19:45 +0100 5423674 http://www.medworm.com/index.php?rid=5401632&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01607.x Conclusions –  The lack of an inverse association between valproate use and hazard ratios for all cancers and several individual cancer sites does not lend support for a cancer‐protective role for valproate. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5401632 Sun, 13 Nov 2011 12:46:18 +0100 5401632 http://www.medworm.com/index.php?rid=5401633&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01617.x Conclusions –  Cardiovascular autonomic function is impaired in patients with ischemic stroke, but patients with carotid stenosis show more severely impaired parasympathetic and sympathetic functions. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5401633 Sat, 12 Nov 2011 05:00:00 +0100 5401633 http://www.medworm.com/index.php?rid=5401634&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01616.x Conclusions–  Pre‐hospital delays reduced the number of patients eligible for IV thrombolysis in both rural and urban areas. The low proportion of patients treated with IV thrombolysis in rural SUs may be attributed to ineffective in‐hospital procedures. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5401634 Fri, 11 Nov 2011 05:00:00 +0100 5401634 http://www.medworm.com/index.php?rid=5389793&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01603.x Pellock JM. Balancing clinical benefits of vigabatrin with its associated risk of vision loss.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 83–91.
© 2011 John Wiley & Sons A/S.Vigabatrin is an effective and well‐tolerated antiepileptic drug (AED) for the treatment of refractory complex partial seizures (rCPS) and infantile spasms (IS), but its benefits must be evaluated in conjunction with its risk of retinopathy with the development of peripheral visual field defects (pVFDs). Vigabatrin should be considered for rCPS if a patient has failed appropriate trials of other AEDs or is not a suitable candidate for other AEDs, is not an optimal surgical candidate, and continues to experience debilitating effects from seizures. Vigabatrin is indicated as monotherapy for pediatric patient... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389793 Thu, 10 Nov 2011 14:10:27 +0100 5389793 http://www.medworm.com/index.php?rid=5389792&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01602.x Walker SD, Kälviäinen R. Non‐vision adverse events with vigabatrin therapy.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 72–82.
© 2011 John Wiley & Sons A/S.Vigabatrin is an effective antiepileptic drug (AED) for the treatment of refractory complex partial seizures (rCPS) and infantile spasms (IS). In clinical trials, vigabatrin was generally well‐tolerated with an adverse event profile similar to that of other AEDs. The most common treatment‐related adverse events were central nervous system effects, including drowsiness, dizziness, headache, and fatigue, with adjunctive vigabatrin in adults with rCPS, and sedation, somnolence, and irritability with vigabatrin monotherapy in infants with IS. Vigabatrin had little effect on cognitive function, mood, or behavior in a batter... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389792 Thu, 10 Nov 2011 14:10:26 +0100 5389792 http://www.medworm.com/index.php?rid=5389791&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01601.x We examined the potential association between pVFDs and epilepsy in vigabatrin‐naïve patients and attempted to identify confounding factors (e.g., concomitant medications, method of vision assessment) to more accurately delineate the prevalence of pVFDs directly associated with vigabatrin. Results of a prospective cohort study as well as several case series and case reports suggest that bilateral visual field constriction is not restricted to patients exposed to vigabatrin but has also been detected, although much less frequently, in vigabatrin‐naïve patients with epilepsy, including those who received treatment with other GABAergic antiepileptic therapy. We also reviewed published data suggesting an association between vigabatrin‐associated retinal toxicity and taurine deficiency,... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389791 Thu, 10 Nov 2011 14:10:24 +0100 5389791 http://www.medworm.com/index.php?rid=5389790&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01600.x This article provides an overview of visual field testing procedures and electroretinography, summarizes the clinical characteristics of vigabatrin‐associated pVFDs, and provides recommendations for visual field and visual electrophysiology testing relevant to both adult and infant patients treated with vigabatrin. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389790 Thu, 10 Nov 2011 14:10:22 +0100 5389790 http://www.medworm.com/index.php?rid=5389789&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01599.x Carmant L. Vigabatrin therapy for infantile spasms: review of major trials in Europe, Canada, and the United States; and recommendations for dosing.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 36–47.
© 2011 John Wiley & Sons A/S.Infantile spasms (IS) are a unique and severe form of epilepsy associated with poor neurologic and developmental outcomes. The refractory spasms and abnormal electroencephalogram (EEG) patterns associated with the condition are believed to have a progressively detrimental impact. Therefore, rapid and complete control of spasms is the primary goal of treatment. Well‐controlled clinical trials in Europe, Canada, and the United States have demonstrated that vigabatrin is efficacious and generally well‐tolerated as monotherapy for IS. Several key studies,... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389789 Thu, 10 Nov 2011 14:10:20 +0100 5389789 http://www.medworm.com/index.php?rid=5389788&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01598.x Faught E. Vigabatrin therapy for refractory complex partial seizures: review of clinical trial experience in the United States.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 29–35.
© 2011 John Wiley & Sons A/S.Vigabatrin is an antiepileptic drug used in more than 50 countries as adjunctive therapy for the treatment of refractory complex partial seizures (rCPS) in adults. First approved in the United Kingdom in 1989, vigabatrin was approved for use in the United States by the Food and Drug Administration in 2009. Although most clinical trials of vigabatrin have been conducted in Europe, three major trials, including two pivotal trials, were conducted in the United States. These trials have demonstrated efficacy and tolerability findings similar to those observed from the European tr... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389788 Thu, 10 Nov 2011 14:10:19 +0100 5389788 http://www.medworm.com/index.php?rid=5389787&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01597.x Ben‐Menachem E, Sander JW. Vigabatrin therapy for refractory complex partial seizures: review of major European trials.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 16–28.
© 2011 John Wiley & Sons A/S.Complex partial seizures (CPS) are a form of localization‐related seizures associated with serious comorbidities and risks. CPS can be difficult to treat and may remain refractory to treatment with antiepileptic drugs (AEDs). Refractory CPS (rCPS) can be hazardous because of the potential for severe dysfunction and bodily harm, sometimes with fatal consequences. Control of seizure activity is critical to the clinical management of CPS. Vigabatrin is a unique AED approved in both Europe and the United States as adjunctive therapy for adult patients with rCPS who have responded ina... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389787 Thu, 10 Nov 2011 14:10:17 +0100 5389787 http://www.medworm.com/index.php?rid=5389786&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01596.x Ben‐Menachem E. Mechanism of action of vigabatrin: correcting misperceptions.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 5–15.
© 2011 John Wiley & Sons A/S.Discovered more than three decades ago, vigabatrin is approved in more than 50 countries as adjunctive therapy for adult patients with refractory complex partial seizures who have responded inadequately to several alternative treatments and as monotherapy for pediatric patients aged 1 month to 2 years with infantile spasms. Contrary to a fairly common misperception, the compound’s mechanism of action is very well‐characterized in animal models and cell cultures. γ‐Aminobutyric acid (GABA)‐ergic synapses comprise approximately 30% of all synapses within the central nervous system, and therein underlies the prima... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389786 Thu, 10 Nov 2011 14:10:16 +0100 5389786 http://www.medworm.com/index.php?rid=5389785&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01606.x Shields WD, Pellock JM. Vigabatrin 35 years later — from mechanism of action to benefit–risk considerations.
Acta Neurol Scand: 2011: 124 (Suppl. 192): 1–4.
© 2011 John Wiley & Sons A/S. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389785 Thu, 10 Nov 2011 14:10:14 +0100 5389785 http://www.medworm.com/index.php?rid=5389781&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01620.x Conclusions –  This study suggests that 1H‐MRS of the cerebellum in patients with ataxia provides information in addition to the presence of atrophy. There are significant 1H‐MRS differences amongst different types of ataxia with interesting correlations between atrophy and NAA/Cr. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389781 Thu, 10 Nov 2011 14:08:05 +0100 5389781 http://www.medworm.com/index.php?rid=5389783&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01618.x Kutlubaev MA, Duncan FH, Mead GE. Biological correlates of post‐stroke fatigue: a systematic review. 
Acta Neurol Scand: DOI: 10.1111/j.1600‐0404.2011.01618.x. 
© 2011 John Wiley & Sons A/S.Fatigue is a common and disabling consequence of stroke. Its mechanisms are unknown. Neuroanatomical abnormalities (e.g. white matter lesions, brain atrophy), neuroendocrine dysregulation, neurotransmitter changes and inflammation are associated with fatigue in conditions other than stroke. This review sought to identify published studies describing associations between post‐stroke fatigue and these biological factors. We searched Medline, EMBASE, CINAHL, PsycINFO and AMED on October 15 and PubMed on 28 December 2010 and included studies in English that recruited at least 10 patients (&gt... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389783 Thu, 10 Nov 2011 05:00:00 +0100 5389783 http://www.medworm.com/index.php?rid=5389782&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01619.x Conclusion –  s – Drug‐resistant patients rapidly titrated to high doses of lacosamide with simultaneous tapering of traditional sodium channel AEDs had marked reduction in CNS‐related adverse events compared with patients treated in three previous pivotal trials that used fixed doses of concomitant AEDs. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389782 Thu, 10 Nov 2011 05:00:00 +0100 5389782 http://www.medworm.com/index.php?rid=5389784&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01615.x Conclusions –  Alongside risk factors conventionally thought to be related to LH, underweight may also be a LH‐related factor, specifically in the elderly. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5389784 Wed, 09 Nov 2011 05:00:00 +0100 5389784 http://www.medworm.com/index.php?rid=5365272&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01613.x Conclusions –  The low copy number of the DEFB4 gene, involving a weakened antimicrobial defense of the host, might be important in the pathogenesis of stroke. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5365272 Thu, 03 Nov 2011 22:47:09 +0100 5365272 http://www.medworm.com/index.php?rid=5365274&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01609.x Conclusions –  By making an early diagnosis, an extensive presurgical evaluation may be avoided, and the patient and their parents may be offered genetic guidance. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5365274 Wed, 02 Nov 2011 04:00:00 +0100 5365274 http://www.medworm.com/index.php?rid=5365273&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01612.x Conclusions –  To our knowledge, our study is the largest case series of patients with steroid‐unresponsive ON treated with PE. Based on our experience, we conclude that PE is an important treatment option for patients with steroid‐unresponsive ON although placebo‐controlled studies are missing until now. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5365273 Wed, 02 Nov 2011 04:00:00 +0100 5365273 http://www.medworm.com/index.php?rid=5365276&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01611.x Conclusion –  The data clearly suggest, however, that the Faroese population is probably not subject to an increased risk of ALS, even though certain risk factors are present in the general population: (i) a fish‐based diet contaminated with mercury and polychlorinated biphenyl; (ii) the high occurrence of the recessive carnitine transporter genetic defect; and (iii) the anticipated high degree of inbreeding at the fifth generation. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5365276 Sat, 29 Oct 2011 04:00:00 +0100 5365276 http://www.medworm.com/index.php?rid=5365275&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01614.x Conclusion –  Multiple impacts to the head raise intracranial pressure and impair cognitive function and exploratory activity in this animal model. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5365275 Sat, 29 Oct 2011 04:00:00 +0100 5365275 http://www.medworm.com/index.php?rid=5365277&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01604.x Conclusions –  In patients with first‐time acute ischemic stroke, unknown thyroid dysfunction is common, and unknown overt or subclinical hyperthyroidism is associated with cardio‐embolic stroke. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5365277 Fri, 28 Oct 2011 04:00:00 +0100 5365277 http://www.medworm.com/index.php?rid=5365278&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01608.x Conclusions –  We conclude that episodes compatible with exercise‐induced myoglobinuria may be frequent in LGMD2I. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5365278 Thu, 27 Oct 2011 04:00:00 +0100 5365278 http://www.medworm.com/index.php?rid=5338049&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.1605.x Conclusions –  STN‐DBS offered no considerable impact on autonomic cardiovascular control. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5338049 Sun, 23 Oct 2011 01:54:12 +0100 5338049 http://www.medworm.com/index.php?rid=5316799&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01593.x Del Brutto OH, Del Brutto VJ. Neurological complications of venomous snake bites: a review.
Acta Neurol Scand: DOI: 10.1111/j.1600‐0404.2011.01593.x.
© 2011 John Wiley & Sons A/S.Abstract –  Snake bite envenoming is a neglected tropical disease affecting millions of people living in the developing world. According to the offending snake species, the clinical picture may be dominated by swelling and soft tissue necrosis in the bitten limb, or by systemic or neurological manifestations. Serious neurological complications, including stroke and muscle paralysis, are related to the toxic effects of the venom, which contains a complex mixture of toxins affecting the coagulation cascade, the neuromuscular transmission, or both. Metalloproteinases, serine proteases, and C‐type l... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5316799 Sat, 15 Oct 2011 14:59:17 +0100 5316799 http://www.medworm.com/index.php?rid=5316801&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01594.x Conclusions –  Patients in whom donepezil is ineffective or poorly tolerated may benefit from a switch to galantamine. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5316801 Thu, 13 Oct 2011 04:00:00 +0100 5316801 http://www.medworm.com/index.php?rid=5316800&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01595.x Conclusions –  The differences found in levels of depression between those with lower functional independence after a stroke compared to those more independent in P‐ADL, raise the possibility that attention should be paid to therapeutic rehabilitation for stroke patients to help them recover as much functional independence as possible in order to improve their quality of life and lower their chances of developing PSD. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5316800 Thu, 13 Oct 2011 04:00:00 +0100 5316800 http://www.medworm.com/index.php?rid=5287332&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01534.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5287332 Thu, 06 Oct 2011 12:27:36 +0100 5287332 http://www.medworm.com/index.php?rid=5287331&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01531.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5287331 Thu, 06 Oct 2011 12:27:35 +0100 5287331 http://www.medworm.com/index.php?rid=5262498&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01592.x Conclusions –  The interest of biomarkers and their ability to solve awkward cases were carefully noticed all the more when a discrepancy between clinical and CSF biological data was involved. The final proposed algorithm allowed to identify pathogenic forms of AD according to the prevailing role of hyperphosphorylated tau or amyloid beta peptide. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5262498 Thu, 29 Sep 2011 13:33:18 +0100 5262498 http://www.medworm.com/index.php?rid=5239836&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01502.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5239836 Thu, 22 Sep 2011 13:42:26 +0100 5239836 http://www.medworm.com/index.php?rid=5239835&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01501.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5239835 Thu, 22 Sep 2011 13:42:24 +0100 5239835 http://www.medworm.com/index.php?rid=5228005&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01583.x Conclusions –  SAI detected using [123I]FP‐CIT SPECT can be used to differentiate VP and PD with a good degree of certainty. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5228005 Wed, 14 Sep 2011 04:00:00 +0100 5228005 http://www.medworm.com/index.php?rid=5228004&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01584.x Conclusions –  There is a mean of 1% loss in power per month in the untreated IBM patient – the rate of loss was greater in the quadriceps muscle and in untreated compared with IS‐treated patients. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5228004 Wed, 14 Sep 2011 04:00:00 +0100 5228004 http://www.medworm.com/index.php?rid=5228003&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01589.x Conclusions –  IL‐6, an atherogenic marker, shows a commensurate increase in stroke patients with OSA. It is correlated with oxyhemoglobin desaturation and with desaturation index and may be a surrogate measure to evaluate continuous positive airway pressure therapy. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5228003 Wed, 14 Sep 2011 04:00:00 +0100 5228003 http://www.medworm.com/index.php?rid=5211033&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01587.x Discussion –  Our scale provides a new practical measure to evaluate NI and disability of DM1 patients. Further longitudinal studies are warranted to confirm its reliability in tracking disease progression and severity over a longer period of time. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5211033 Thu, 08 Sep 2011 04:00:00 +0100 5211033 http://www.medworm.com/index.php?rid=5228002&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01591.x Conclusions –  Among patients with OH, we found an association between the presence of syncope and impaired VMR. Assessment of VMR among patients with OH may predict those who are at higher risk to faint and fall and to support more aggressive intervention. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5228002 Thu, 01 Sep 2011 04:00:00 +0100 5228002 http://www.medworm.com/index.php?rid=5211032&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01590.x Conclusions –  In this population study, the annual incidence of a first‐time craniotomy for a brain metastasis was 2.6/100,000, the 30‐day mortality rate was 3.8%, and median OS was 9.2 months. The well‐known prognostic factors were confirmed. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5211032 Thu, 01 Sep 2011 04:00:00 +0100 5211032 http://www.medworm.com/index.php?rid=5171226&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01588.x Conclusions –  Perampanel was well tolerated across doses of 4–12 mg/day. The studies showed preliminary evidence of efficacy and identified doses to be evaluated in larger clinical studies. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5171226 Mon, 29 Aug 2011 17:22:30 +0100 5171226 http://www.medworm.com/index.php?rid=5164359&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01586.x Conclusion –  The finding of one conjugal pair and abnormal VEP in a further four MS partners could have several explanations. It is compatible with the concept of a transmissible agent, although our observations could be due to several biases as well as the play of chance alone. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5164359 Sat, 27 Aug 2011 17:40:00 +0100 5164359 http://www.medworm.com/index.php?rid=5111308&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01570.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5111308 Wed, 10 Aug 2011 22:01:04 +0100 5111308 http://www.medworm.com/index.php?rid=5111304&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01582.x Conclusion –  An acute stroke centre today requires a high degree of neurological expertise in assessing patients admitted with possible stroke. Most patients with stroke have no or mild deficits and need above all rapid diagnostic work‐up, acute and prophylactic treatment. In‐hospital rehabilitation is essential for a smaller number of patients who suffer from persisting neurological deficits after stroke. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5111304 Wed, 10 Aug 2011 22:00:02 +0100 5111304 http://www.medworm.com/index.php?rid=5111307&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01579.x Conclusions –  These findings suggest that changes in HGF in ALS skin are related to the disease process and that metabolic alterations of HGF may take place in the skin of patients with ALS. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5111307 Mon, 08 Aug 2011 23:00:00 +0100 5111307 http://www.medworm.com/index.php?rid=5111306&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01580.x Conclusions –  Our data suggest that the prevalence of thyroid carcinoma in cases of MG may be higher than that of the general population. Furthermore, in patients with MG, there is a possibility that the stage of the carcinoma is higher even when the carcinoma is of a very small size. Patients with MG, when diagnosed, should be advised to undergo US screening of the thyroid because most cases of thyroid carcinoma are highly curable. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5111306 Mon, 08 Aug 2011 23:00:00 +0100 5111306 http://www.medworm.com/index.php?rid=5111305&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01581.x Conclusion –  Positive family history for RLS together with reduced/absent residual renal function and peripheral neuropathy predicts the risk for RLS in ESKD patients undergoing HD. Longitudinal studies are warranted to correlate RLS occurrence with genetic and environmental factors. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5111305 Mon, 08 Aug 2011 23:00:00 +0100 5111305 http://www.medworm.com/index.php?rid=5071859&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01578.x Conclusions –  Overweight may be associated with reduced risk of aSAH, but there was no over all association of total serum cholesterol, HDL cholesterol, or triglycerides with the risk of aSAH in this prospective study. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5071859 Fri, 29 Jul 2011 14:15:54 +0100 5071859 http://www.medworm.com/index.php?rid=5071860&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01571.x Conclusion –  There is a moderate risk of MS in Chile. The southernmost region showed significantly higher incidence rates than those in the rest of the country (a cluster zone). We did not find any correlation between incidence rates and latitude or UV radiation. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5071860 Wed, 27 Jul 2011 23:00:00 +0100 5071860 http://www.medworm.com/index.php?rid=5071861&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01574.x Conclusion –  Our results suggest that even in the NABT MR detects changes likely to be associated with an underlying pathology and possibly contributes to the cognitive impairment in MS. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5071861 Tue, 26 Jul 2011 23:00:00 +0100 5071861 http://www.medworm.com/index.php?rid=5054149&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01577.x Conclusion –  Physiological variation in vitamin D does not exert a major impact on intrathecal synthesis of IgG in MS. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5054149 Sat, 23 Jul 2011 18:39:18 +0100 5054149 http://www.medworm.com/index.php?rid=5054150&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01576.x Conclusions –  The findings indicate that DoD can be used as a quantitative indicator of the functional impairments following stroke, i.e. it can serve as a potential surrogate of the severity of the damage. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5054150 Fri, 22 Jul 2011 23:00:00 +0100 5054150 http://www.medworm.com/index.php?rid=5041641&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01573.x Conclusion –  There was a significantly higher prevalence and greater severity of sleep disturbances, fatigue, pain, anxiety, and depression in patients with ET and depression significantly affected the QOL. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5041641 Wed, 20 Jul 2011 20:51:12 +0100 5041641 http://www.medworm.com/index.php?rid=5041642&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01575.x Conclusion –  EPC caused by TBRSSE is relatively frequent in the Eastern parts of the Russian Federation but not west of the Ural. Unlike Rasmussen encephalitis, EPC with TBRSSE does not progress even in the long term. It appears as disabling but not fatal condition with a time course where three phases can be distinguished. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5041642 Mon, 18 Jul 2011 23:00:00 +0100 5041642 http://www.medworm.com/index.php?rid=5031855&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01572.x Conclusions– We describe SOX1 reactivity for the first time overlapping with CV2/CRMP5 and amphiphysin antibodies. SOX1 reactivity is predominantly associated with Hu antibodies and SCLC, but can occur also in other types of lung cancer. Neurological manifestations present in patients with coexisting SOX1 antibodies and well‐characterized antineuronal antibodies do not differ from those previously described in patients positive for antineuronal antibodies but no SOX1‐specific anti‐glial antibodies. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=5031855 Sun, 17 Jul 2011 00:27:44 +0100 5031855 http://www.medworm.com/index.php?rid=4987459&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01563.x Conclusion –  Our findings argue against the presence of an altered lipid metabolism as a risk factor for the development of cerebrovascular disease in patients with RLS, even if they do support the idea that cerebrovascular disease might be frequent in this condition. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4987459 Fri, 01 Jul 2011 21:00:53 +0100 4987459 http://www.medworm.com/index.php?rid=4978646&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01569.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978646 Wed, 29 Jun 2011 19:47:52 +0100 4978646 http://www.medworm.com/index.php?rid=4978645&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01551.x Svalheim S, Røste LS, Nakken KO, Taubøll E. Bone health in adults with epilepsy.
Acta Neurol Scand: 2011: 124 (Suppl. 191): 89–95.
© 2011 John Wiley & Sons A/S.Patients with epilepsy have a 2–6 times greater risk of bone fractures compared with the general population. There are several potential explanations. Some fractures are caused by seizure‐related injuries, or they may be associated with the osteopenic effect of reduced physical activity in patients with epilepsy. Antiepileptic drugs (AEDs), especially those that affect the liver enzymes, e.g., phenytoin, carbamazepine, phenobarbital, as well as valproate, are also associated with increased fracture rate and low bone mineral density. Many patients with epilepsy and general practitioners seem unaware of this problem. ... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978645 Wed, 29 Jun 2011 19:47:51 +0100 4978645 http://www.medworm.com/index.php?rid=4978644&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01549.x Conclusions –  The onconeural antibodies are directed against intracellular antigens and their pathogenic role is still largely unknown. They are highly specific markers of paraneoplastic aetiology in patients with neurological symptoms. Detection of an onconeural antibody in a patient with neurological symptoms should lead to prompt investigation for cancer. However, absence of detectable onconeural antibodies does not exclude the PNS diagnosis. In particular, failure to detect antibodies in patients without classical PNS symptoms may result in less vigorous cancer screening and diagnostic delay. Neuronal antibodies that are directed to synaptic proteins or proteins of the cell membrane are also associated with neurological symptoms, and probably have pathogenic effects. The associat... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978644 Wed, 29 Jun 2011 19:47:51 +0100 4978644 http://www.medworm.com/index.php?rid=4978643&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01548.x Conclusions –  Fall tendency may occur early in the disease course of MS, before impairment of locomotion and balance becomes evident on clinical examination. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978643 Wed, 29 Jun 2011 19:47:50 +0100 4978643 http://www.medworm.com/index.php?rid=4978642&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01547.x Conclusions –  Patients with SCI have a high risk of cardiovascular complications, AD and urinary autonomic dysfunction both in the acute phase and later, affecting their prognosis and quality of life. Knowledge of cardiovascular and urological complications after SCI is important for proper diagnosis and treatment. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978642 Wed, 29 Jun 2011 19:47:49 +0100 4978642 http://www.medworm.com/index.php?rid=4978641&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01546.x Mellgren SI, Lindal S. Nerve biopsy – some comments on procedures and indications.
Acta Neurol Scand: 2011: 124 (Suppl. 191): 64–70.
© 2011 John Wiley & Sons A/S.Nerve biopsy is most often a final step in the evaluation of patients with peripheral neuropathy. The procedure should always be expected to result in varying degree of sensory loss within the innervation area of the biopsied nerve and chronic pain in the area may also occur. Therefore appropriate informed consent must be obtained and a weighing of such side effects and benefits for the patient, particularly therapeutical consequences, should be seriously considered before the procedure is performed. The surgical procedure and the processing in the laboratory of the nerve material must hold a high standard at all leve... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978641 Wed, 29 Jun 2011 19:47:49 +0100 4978641 http://www.medworm.com/index.php?rid=4978640&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01545.x Conclusions from four longitudinal studies of quantitative EEG and steady‐state visual‐evoked potentials in migraineurs.
Acta Neurol Scand: 2011: 124 (Suppl. 191): 56–63.
© 2011 John Wiley & Sons A/S.Objectives –  Quantitative electroencephalograpic (QEEG) frequency spectra and steady‐state visual‐evoked potentials (SSVEP) are indicators of corticothalamic excitability (e.g., arousal). Increased interictal excitability is suggested to be an important element in the migraine pathophysiology. In this paper, we summarize our results from four studies of QEEG and SSVEP recordings in migraineurs interictally and in the days before an attack with the intention to shed light on attack‐initiating mechanisms.Material and methods –  Thirty‐two healthy controls, 33 mi... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978640 Wed, 29 Jun 2011 19:47:48 +0100 4978640 http://www.medworm.com/index.php?rid=4978639&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01544.x Conclusion –  At present, BoNT cannot be firmly recommended as an evidence‐based treatment in secondary headaches or cranial neuralgias. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978639 Wed, 29 Jun 2011 19:47:47 +0100 4978639 http://www.medworm.com/index.php?rid=4978638&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01543.x Conclusion –  We argue that MS, like a number of other chronic diseases, is a cause of secondary osteoporosis. Therefore, bone health assessment should be a part of the integral management of persons with MS. We suggest that BMD be measured shortly after diagnosis, that BMD measurements be repeated depending on BMD values and individual osteoporosis risk profile, and that serum 25‐hydroxyvitamin D be monitored. All persons with MS should receive bone health advice. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978638 Wed, 29 Jun 2011 19:47:46 +0100 4978638 http://www.medworm.com/index.php?rid=4978637&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01542.x Discussion –  Early introduction of prophylactic medication was an effective way to reduce headache days during the first 3 months, and the notion that patients with MOH need withdrawal of analgesics to respond to preventive medication seems to be incorrect. The long‐term prognosis during the 4‐year follow‐up was relatively favorable as there was a steady decline in headache, one‐third of the patients with MOH having ≥50% reduction in headache frequency from baseline and two‐thirds being without medication overuse. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978637 Wed, 29 Jun 2011 19:47:46 +0100 4978637 http://www.medworm.com/index.php?rid=4978636&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01540.x Conclusions –  Sufficiently powered RCTs to evaluate the effect of thrombectomy with mechanical devices are warranted, but as the natural course of a large vessel stroke carries a devastating prognosis, a proactive recanalization approach is justified based on today’s knowledge. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978636 Wed, 29 Jun 2011 19:47:45 +0100 4978636 http://www.medworm.com/index.php?rid=4978635&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01539.x Conclusions –  Both men and women treated with LEV monotherapy have lower blood platelet counts than healthy controls, with no difference in Hb or WBC. Haematological changes observed with the other AEDs were minor. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978635 Wed, 29 Jun 2011 19:47:44 +0100 4978635 http://www.medworm.com/index.php?rid=4978634&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01538.x Arntzen KA, Mathiesen EB. Subclinical carotid atherosclerosis and cognitive function.
Acta Neurol Scand: 2011: 124 (Suppl. 191): 18–22.
© 2011 John Wiley & Sons A/S.Carotid artery atherosclerosis is a major risk factor for stroke and subsequent cognitive impairment. Recent studies indicate that carotid atherosclerosis without clinical stroke may also be an independent risk factor for cognitive decline and dementia. Ultrasonography is an easily assessable and non‐invasive method to measure different stages of the carotid artery atherosclerotic process and is widely used in clinical assessment as well as in epidemiological and clinical research. We give a brief review of studies that have investigated degrees of the subclinical atherosclerosis in the carotid arteries in relation... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978634 Wed, 29 Jun 2011 19:47:43 +0100 4978634 http://www.medworm.com/index.php?rid=4978633&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01537.x Conclusion–  Boys with epilepsy exhibit risk‐taking behaviour more frequently than controls. Other risk factors for this behaviour were living with a single parent, low family income and psychiatric symptoms. This behavioural association should be addressed as it probably contributes to the negative social outcomes that frequently occur in the adult epilepsy population. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978633 Wed, 29 Jun 2011 19:47:43 +0100 4978633 http://www.medworm.com/index.php?rid=4978632&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01550.x Storstein A. Communication and neurology – bad news and how to break them.
Acta Neurol Scand: 2011: 124 (Suppl. 191): 5–11.
© 2011 John Wiley & Sons A/S.How to deliver bad news to patients is a crucial part of medical practice. Many neurological diseases are incurable, progressive and result in physical or cognitive disabilities, which pose special challenges in the process of communication. Information about diagnosis, therapy and prognosis should be given in an appropriate setting and tailored to the patient’s needs and cognitive level of functioning. Support and advice to the family and a team‐oriented approach in the follow‐up of neurological patients are of high importance. Patient autonomy, truth disclosure expectations and the access to other sources of informatio... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978632 Wed, 29 Jun 2011 19:47:42 +0100 4978632 http://www.medworm.com/index.php?rid=4978631&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01541.x Conclusion –  Open‐handedness and a willingness to co‐operate should be a hallmark for neurologists. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978631 Wed, 29 Jun 2011 19:47:41 +0100 4978631 http://www.medworm.com/index.php?rid=4978619&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01562.x Conclusions –  As compared to previous small series describing only patients responding to TPM, this unselected observation underscores the difficulty of treating refractory SE, regardless of the agent. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978619 Wed, 29 Jun 2011 19:46:22 +0100 4978619 http://www.medworm.com/index.php?rid=4978622&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01552.x Conclusions –  There is a need for follow‐up not only to re‐assess skills and needs partly owing to new technologies but also to see whether the person needs more assistance to adapt to the alternative means of communication or whether the carers of the person need extra information about communication. We conclude that the low incidence of the syndrome necessitates a skilled team in which different professionals can together assess the person. This probably requires some centralization. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978622 Mon, 27 Jun 2011 23:00:00 +0100 4978622 http://www.medworm.com/index.php?rid=4978621&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01561.x Conclusion –  LPA holds promise in PD research as it uncovered three PD subtypes distinguished by motor symptoms and disease progression and validated by cognitive variables. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978621 Mon, 27 Jun 2011 23:00:00 +0100 4978621 http://www.medworm.com/index.php?rid=4978620&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01568.x Conclusion –  Modified‐release granule formulation of VPA may be a reliable alternative to solution for its convenience of use. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4978620 Mon, 27 Jun 2011 23:00:00 +0100 4978620 http://www.medworm.com/index.php?rid=4971566&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01554.x Conclusions –  The IgM immunoreactivity in serum did not show any relationship to the type of course or severity of MS, arguing against a phenomenon secondary to myelin damage. Thus, the IgM antibody findings are compatible with an early antigen challenge or autoimmunity associated with natural antibodies. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4971566 Mon, 27 Jun 2011 22:33:16 +0100 4971566 http://www.medworm.com/index.php?rid=4971567&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01558.x Conclusions –  The low completeness reduces the usefulness of the LPR in epidemiological MS research, in particular incidence studies. The study also found that the completeness of the LPR could be increased to 92.8% by including LPR records from other departments in addition, but this reduced the validity of the LPR to 95.1%. However, these results cannot uncritically be applied to registration of other diseases in the LPR. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4971567 Thu, 23 Jun 2011 23:00:00 +0100 4971567 http://www.medworm.com/index.php?rid=4955833&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01560.x Conclusions –  These observations support the psychometric properties of the Swedish PFS‐16, but cautions against dichotomised scoring. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4955833 Wed, 22 Jun 2011 19:52:33 +0100 4955833 http://www.medworm.com/index.php?rid=4955835&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01556.x Conclusion –  The presence and extent of subcortical hypermetabolism in PD is dependent on type of normalization. However, the present findings suggest that PD, in addition to widespread cortical hypometabolism, is probably characterized by true hypermetabolism in the GPe. This finding was predicted by the animal 2‐deoxyglucose autoradiography literature, in which high‐magnitude hypermetabolism was also most robustly detected in the GPe. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4955835 Mon, 20 Jun 2011 23:00:00 +0100 4955835 http://www.medworm.com/index.php?rid=4955834&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01557.x Conclusions –  Post‐stroke fatigue appears to be an independent determinant of not being able to resume paid work following stroke. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4955834 Mon, 20 Jun 2011 23:00:00 +0100 4955834 http://www.medworm.com/index.php?rid=4939686&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01555.x Conclusion –  The present meta‐analysis added additional evidence indicating the efficacy of sunlight exposure for reducing the risk of hip fractures in patients with Alzheimer’s disease, Parkinson’s disease, and stroke. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4939686 Sat, 18 Jun 2011 19:39:11 +0100 4939686 http://www.medworm.com/index.php?rid=4924567&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01553.x Conclusion –  Compared with epilepsy, which is only rarely caused by immunological mechanisms, the autoimmune disorder MS was not associated with a different occurrence of CBZ skin reactions. The trend towards an increased occurrence of rashes in MS can partly be explained by a higher predisposition to CBZ rash in women of fertile age. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4924567 Mon, 13 Jun 2011 23:27:52 +0100 4924567 http://www.medworm.com/index.php?rid=4915425&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01535.x Arya R, Gulati S. Phenytoin‐induced gingival overgrowth.
Acta Neurol Scand: DOI: 10.1111/j.1600‐0404.2011.01535.x.
© 2011 John Wiley & Sons A/S.Gingival overgrowth is a common adverse effect of therapy with Phenytoin, having important medical and cosmetic implications. Poor periodontal hygiene is an important risk factor for severity of Phenytoin‐induced gingival overgrowth (PIGO), which is a time‐dependent process. There is complex interplay of altered fibroblast biology, connective tissue turnover, inflammatory processes, and growth factors on a background of genetic susceptibility to produce increase in various components of interstitial matrix in PIGO tissue. Treatment options have included change of PHT to another anti‐seizure drug, measures to improve periodontal h... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4915425 Fri, 10 Jun 2011 18:31:07 +0100 4915425 http://www.medworm.com/index.php?rid=4915429&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01528.x Conclusions –  Our results suggest a systemic immune activation in patients with ALS. The high production of CD8+ T and NKT cells may suggest an immunological reaction to some unknown or undetected endogenous proteins or viruses. A probably dual (neurodestructive or neuroprotective) inflammatory function of Treg cells cannot be excluded. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4915429 Wed, 08 Jun 2011 23:00:00 +0100 4915429 http://www.medworm.com/index.php?rid=4915427&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01530.x Conclusion –  The Prof‐M is a simple self‐report measure which could be useful in screening PSS subjects who may benefit from detailed psychometric evaluation. Our results are consistent with the hypothesis that depression and verbal memory impairment are overlapping but independent aspects of neural involvement in PSS. While pain and depression are significant confounders of cognitive function in PSS, this study suggests that impaired verbal reasoning ability in PSS is not attributable to pain or depression. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4915427 Wed, 08 Jun 2011 23:00:00 +0100 4915427 http://www.medworm.com/index.php?rid=4915426&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01533.x Conclusion –  Infusion testing was safe and without serious adverse events with a high rate of successful procedures. The investigation was associated with expected mild to moderate discomfort. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4915426 Wed, 08 Jun 2011 23:00:00 +0100 4915426 http://www.medworm.com/index.php?rid=4905767&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2010.01439.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4905767 Wed, 08 Jun 2011 14:00:38 +0100 4905767 http://www.medworm.com/index.php?rid=4905766&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2010.01438.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4905766 Wed, 08 Jun 2011 14:00:37 +0100 4905766 http://www.medworm.com/index.php?rid=4905765&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2010.01458.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4905765 Wed, 08 Jun 2011 14:00:36 +0100 4905765 http://www.medworm.com/index.php?rid=4905764&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2010.01457.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4905764 Wed, 08 Jun 2011 14:00:36 +0100 4905764 http://www.medworm.com/index.php?rid=4905763&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2010.01449.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4905763 Wed, 08 Jun 2011 14:00:35 +0100 4905763 http://www.medworm.com/index.php?rid=4905758&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01536.x Conclusions –  Further studies are needed to confirm such effects of tetracycline in patients with PEO, if any, and to clarify the mechanisms of action for antioxidant effects of tetracyclines in mitochondrial disorders and other diseases. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4905758 Wed, 08 Jun 2011 13:59:13 +0100 4905758 http://www.medworm.com/index.php?rid=4905761&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01514.x Conclusions –  Gender differences have been identified on the risk factors profile and diagnostic and therapeutic management of patients with ischemic stroke. Active measures should thus be taken to avoid bias in clinical practice. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4905761 Tue, 07 Jun 2011 23:00:00 +0100 4905761 http://www.medworm.com/index.php?rid=4905760&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01529.x Conclusion –  High‐dose paracetamol reduces not only body temperature but also systolic blood pressure in the first 12 h after start of treatment. Both effects may improve functional outcome after stroke, but this needs further study. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4905760 Tue, 07 Jun 2011 23:00:00 +0100 4905760 http://www.medworm.com/index.php?rid=4905759&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01532.x Conclusion –  IFNβ treatment could worsen HA in patients with pre‐existing HA or cause the appearance of new HA. Among different IFNβ preparations, Rebif® 44 and Avonex® seemed to be more cephalalgic than the other drugs. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4905759 Tue, 07 Jun 2011 23:00:00 +0100 4905759 http://www.medworm.com/index.php?rid=4866334&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01527.x Conclusion –  This prospective, blinded, pilot study is the first to indicate the diagnostic potential of US, as performed routinely, in distinguishing between acquired demyelinating and axonal neuropathy. These findings now require confirmation in larger, adequately designed studies, evaluating other nerves/nerve sites, assessing healthy controls and taking into account interrater and equipment variabilities. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4866334 Fri, 27 May 2011 14:02:50 +0100 4866334 http://www.medworm.com/index.php?rid=4866340&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01521.x Conclusion –  Our study suggests that isolated seizures cause minimal neuronal injury in rats. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4866340 Wed, 25 May 2011 23:00:00 +0100 4866340 http://www.medworm.com/index.php?rid=4866339&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01522.x Conclusion –  In the examination of circadian variation of stroke case fatality, 28‐day case fatality rate tended to be higher for the morning strokes. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4866339 Wed, 25 May 2011 23:00:00 +0100 4866339 http://www.medworm.com/index.php?rid=4866338&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01523.x Conclusions– DLI improves QoL in patients with advanced PD after short‐ and long‐term exposure. Whereas all domains except social support improve after 6 months under DLI, only mobility, activities of daily living and emotional well‐being improve significantly after long‐term exposure to DLI. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4866338 Wed, 25 May 2011 23:00:00 +0100 4866338 http://www.medworm.com/index.php?rid=4866337&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01524.x Rentzos M, Rombos A. The role of IL‐15 in central nervous system disorders.
Acta Neurol Scand: DOI: 10.1111/j.1600‐0404.2011.01524.x.
© 2011 John Wiley & Sons A/S.IL‐15 is a proinflammatory cytokine. It is produced by activated blood monocytes, macrophages, dendritic cells, and activated glial cells. It promotes T‐cell proliferation, induction of cytolytic effector cells including natural killer and cytotoxic cells and stimulates B‐cell to proliferate and secrete immunoglobulins. Little information is available on the exact role of IL‐15 in the neurological diseases. Microglial cells are the main regulators of both innate and adaptive immune responses in the central nervous system (CNS). IL‐15 may be involved in the inflammatory reactions and microglial activation of... Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4866337 Wed, 25 May 2011 23:00:00 +0100 4866337 http://www.medworm.com/index.php?rid=4866336&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01525.x Conclusions –  Galantamine reduces behavioral symptoms in patients with mild to moderate AD, leading to reduced caregiver burden. The reductions were greatest in patients with moderate or advanced moderate disease. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4866336 Wed, 25 May 2011 23:00:00 +0100 4866336 http://www.medworm.com/index.php?rid=4866335&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01526.x Conclusions – Comorbidity is associated with reduced HRQOL in MS. Further research should evaluate whether more aggressive treatment of comorbidities improves the HRQOL of MS patients. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4866335 Wed, 25 May 2011 23:00:00 +0100 4866335 http://www.medworm.com/index.php?rid=4795770&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01520.x Conclusion –  Ventriculomegaly is a common finding in elderly. One out of 20 patients with TIA may suffer from INPH, existing before and independent of the TIA diagnosis. Therefore, patients presenting with ventriculomegaly and gait/balance disturbances not attributable to other causes should be referred to a hydrocephalus centre or a neurologist with special interest in INPH. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4795770 Sat, 07 May 2011 21:11:30 +0100 4795770 http://www.medworm.com/index.php?rid=4795771&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01519.x Conclusion –  The results indicate that EMMPRIN is implicated in pathophysiology of ALS and may be the marker of clinical state severity. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4795771 Fri, 06 May 2011 23:00:00 +0100 4795771 http://www.medworm.com/index.php?rid=4711182&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2010.01471.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4711182 Thu, 14 Apr 2011 20:52:53 +0100 4711182 http://www.medworm.com/index.php?rid=4711181&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2010.01470.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4711181 Thu, 14 Apr 2011 20:52:53 +0100 4711181 http://www.medworm.com/index.php?rid=4688036&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01518.x Conclusions –  These results demonstrate that the Norwegian‐language version of the MusiQoL questionnaire is a valid and reliable instrument for assessing health‐related QoL in Norwegian patients with MS. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4688036 Fri, 08 Apr 2011 18:27:42 +0100 4688036 http://www.medworm.com/index.php?rid=4688038&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01513.x Discussion –  Our study clearly demonstrated the relationships between coping strategies and medical as well as demographic variables. These results encourage us to develop further investigations to better understand these relationships and to offer better adapted psychological interventions for patients with ALS. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4688038 Wed, 06 Apr 2011 23:00:00 +0100 4688038 http://www.medworm.com/index.php?rid=4688037&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01516.x Deng H, Gu S, Jankovic J. LINGO1 variants in essential tremor and Parkinson’s disease.
Acta Neurol Scand: DOI: 10.1111/j.1600‐0404.2011.01516.x.
© 2011 John Wiley & Sons A/S.The leucine‐rich repeat and Ig domain containing 1 gene (LINGO1), recently considered to be conferred increased risk of essential tremor (ET), has been also implicated in Parkinson disease (PD). As the two common movement disorders have overlapping clinical and pathological features, it has been postulated that the LINGO1 gene may play a role in the pathogenesis of the two diseases. Here, we review published reports of the LINGO1 variants in ET and PD in an attempt to better understand the molecular and pathogenic relationship of LINGO1 to the two disorders. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4688037 Wed, 06 Apr 2011 23:00:00 +0100 4688037 http://www.medworm.com/index.php?rid=4688041&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01510.x Conclusion –  The epileptogenic hippocampal atrophy has an anatomically distinct pattern compared with the contralateral hippocampus. This information may help guide the presurgical assessment of MTLE. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4688041 Tue, 05 Apr 2011 23:00:00 +0100 4688041 http://www.medworm.com/index.php?rid=4688040&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01515.x Conclusions –  Impairment of DCA ipsilateral to acute ischemic stroke is associated with larger infarction. Dysautoregulation tends to worsen and spread to the contralateral side over the first days post‐stroke and is associated with poor clinical outcome. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4688040 Tue, 05 Apr 2011 23:00:00 +0100 4688040 http://www.medworm.com/index.php?rid=4688039&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01517.x Conclusion –  Our study estimates high direct costs in patients with PD in Sweden, SEK 1.7 billion, 52% for inpatient care, 27% for outpatient care and 21% for drugs. With an ageing population and the medical progress, the financial burden on society will most probably increase in the future. This study might initiate and provide information for discussions about future cost allocations and healthcare priorities. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4688039 Tue, 05 Apr 2011 23:00:00 +0100 4688039 http://www.medworm.com/index.php?rid=4628273&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01512.x Conclusion –  This study confirms that mood disorders are frequent in CADASIL. The use of a structured psychiatric interview outlines a frequency of depression higher than that previously reported but also reveals a considerable frequency of bipolar disorders. If confirmed in larger series, these data suggest that a greater attention should be paid to the psychiatric aspects in CADASIL. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4628273 Thu, 24 Mar 2011 18:40:03 +0100 4628273 http://www.medworm.com/index.php?rid=4628276&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01503.x Conclusion –  A predominance of the AIDP variant was seen, and the incidence of the disease decreased with age. As expected, the distribution of weakness correlated with the clinical variants, and individuals with the axonal variant had a poorer prognosis. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4628276 Thu, 24 Mar 2011 00:00:00 +0100 4628276 http://www.medworm.com/index.php?rid=4628275&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01511.x Conclusions –  Our data provide preliminary evidence that GBS is associated with low CSF index levels of prealbumin and fibrinogen, but normal levels of haptoglobin, whereas CIDP is associated with normal CSF index levels of prealbumin, low fibrinogen, and high levels of haptoglobin. Further studies are needed to identify the underlying mechanisms behind these CSF protein alterations and to clarify whether prealbumin, fibrinogen, and haptoglobin can serve as useful biomarkers for GBS and CIDP. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4628275 Thu, 24 Mar 2011 00:00:00 +0100 4628275 http://www.medworm.com/index.php?rid=4628274&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01508.x Conclusion –  Surprisingly, upper gastrointestinal transit is prolonged in subjects with SCI suffering from bowel problems, not only in subjects with cervical or high thoracic lesions but also in subjects with conal/cauda equina lesions. We speculate that this is secondary to colonic dysfunction and constipation. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4628274 Thu, 24 Mar 2011 00:00:00 +0100 4628274 http://www.medworm.com/index.php?rid=4623771&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2010.01456.x (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4623771 Wed, 23 Mar 2011 18:44:25 +0100 4623771 http://www.medworm.com/index.php?rid=4617756&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01507.x Conclusions –  Add‐on PGB benefited 50% of patients, but only 10% achieved 6 months’ seizure freedom. Adverse effects, most commonly sedation, dose‐related weight gain and ataxia, led to drug discontinuation by 45%. Prospective audits of novel AEDs are a useful adjunct to randomized, controlled trials in managing epilepsy. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4617756 Tue, 22 Mar 2011 18:58:20 +0100 4617756 http://www.medworm.com/index.php?rid=4617758&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01504.x Conclusions –  These are the first families with SCA14 reported from Scandinavia and a new mutation in the PRKCG gene. The occurrence in the Norwegian dominant ataxia cohort is 3.5%. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4617758 Mon, 21 Mar 2011 00:00:00 +0100 4617758 http://www.medworm.com/index.php?rid=4617757&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01509.x Conclusion – In this high‐risk population, we obtained a positive and strong correlation between the occurrence of fractures in a diagnosed population with osteoporosis and the cumulative drug load of AEDs. This effect seems general, independent of the type of AEDs that were used. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4617757 Mon, 21 Mar 2011 00:00:00 +0100 4617757 http://www.medworm.com/index.php?rid=4607385&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01506.x Conclusions –  OSA is more prevalent in refractory epilepsy and in children who are on multiple AEDs. While further studies are needed to confirm these findings and to assess the consequences of OSA, we believe it is important to screen the children with epilepsy for OSA. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4607385 Thu, 17 Mar 2011 00:00:00 +0100 4607385 http://www.medworm.com/index.php?rid=4597003&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01505.x Conclusions –  We failed to find an association between the IL6 ‐174G>C polymorphism and aSAH in analyzed European populations. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4597003 Wed, 16 Mar 2011 00:00:00 +0100 4597003 http://www.medworm.com/index.php?rid=4533608&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2010.01402.x Conclusions –  Quality follow‐up within stroke care could be biased or have low comparability, when administrative data are used. Great caution should be taken when data derived from the inpatient and cause‐of‐death registers, and more validation work needs to be carried out in the context of stroke. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4533608 Tue, 01 Mar 2011 22:51:49 +0100 4533608 http://www.medworm.com/index.php?rid=4533607&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2010.01394.x Conclusions –  Intravenous Sodium Valproate (iVPA) seems to be safe and rapidly effective for intractable migraine attack. Randomized, double‐blinded, controlled studies are warranted. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4533607 Tue, 01 Mar 2011 22:51:42 +0100 4533607 http://www.medworm.com/index.php?rid=4533606&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01498.x Conclusions –  Contralateral silent period (SP) seems to be a valuable parameter to early distinguish patients who will develop MS or not. This result about SP during CIS has never been described until now. An increased contralateral silent period would predict a conversion to MS with a positive predictive value of 75%, but this result needs to be confirmed in larger groups. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4533606 Tue, 01 Mar 2011 00:00:00 +0100 4533606 http://www.medworm.com/index.php?rid=4533605&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01500.x Conclusion –  The risk for MI is significantly higher, for both male and female stroke patients, compared to the general population. Stroke patients with previous CHD and peripheral artery disease are at highest risk. Stroke patients should receive adequate secondary prevention, and cardiac complaints must be taken seriously. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4533605 Tue, 01 Mar 2011 00:00:00 +0100 4533605 http://www.medworm.com/index.php?rid=4533604&cid=s_32218_25_f&fid=32218&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0404.2011.01499.x Conclusions–  Although our estimates are likely to be affected by access to health services, overall treated epilepsy prevalence of 4.4 per 1000 is similar to previous studies. Our finding of high elderly prevalence has been reported in a few recent studies in developed countries and has important clinical and public health implications in populations with similar aging demographics. (Source: Acta Neurologica Scandinavica) Acta Neurologica Scandinavica journals http://www.medworm.com/rss/comments.php?id=4533604 Tue, 01 Mar 2011 00:00:00 +0100 4533604