MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Acta Oto-Laryngologica' source. Wed, 08 Feb 2012 15:44:29 +0100 http://www.medworm.com/index.php?rid=5580183&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216922%26dopt%3DAbstract Conclusion: Sensorineural hearing loss (SNHL) is a neurological situation and celiac disease (CD) may be seen coincidentally. Children with clinical signs of hearing deficiency of unknown etiology should be assessed for CD. Objective: CD is a chronic inflammatory gluten-dependent intestinal disease and has extraintestinal findings. The aim of this study was to determine the incidence of CD and SNHL in our pediatric patients. Methods: A total of 25 pediatric patients (50 ears) with biopsy-proven CD were diagnosed in the pediatric gastroenterology department; 25 healthy control subjects (50 ears) were also included in the study. All subjects underwent pure tone audiometry at frequencies of 250-8000 Hz and tympanometry. Results: In the patients and controls, normal peak compliance, gradient, ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580183 Fri, 13 Jan 2012 04:13:35 +0100 5580183 http://www.medworm.com/index.php?rid=5580174&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22229875%26dopt%3DAbstract Conclusion. Our results showed that the behavior of moderate dysplasia lesions was more like that of severe dysplasia lesions, while severe dysplasia was very different from carcinoma in situ (CIS). CIS should be managed more aggressively than the other lesions. Mild dysplasia could not be viewed as a precancerous lesion of the larynx. Objective: This study aimed to identify the possibilities of the precancerous lesions of larynx (including mild dysplasia, moderate dysplasia, severe dysplasia, and CIS) progressing to invasive carcinomas and to highlight the importance of adequate management and follow-up strategies for these patients. Methods: A retrospective study of patients who had these preinvasive lesions in the larynx over a 10-year period was performed. Results: These patients were ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580174 Mon, 09 Jan 2012 05:00:00 +0100 5580174 http://www.medworm.com/index.php?rid=5580175&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22224578%26dopt%3DAbstract Conclusion: The morbidity of the complications has had a decreased tendency in recent decades, but the category of the complications was rather diverse. There are still many serious complications that require our attention. Surgery is still the most important treatment option. Objective: To investigate otogenic extracranial and intracranial complications in patients with acute and chronic otitis media. Methods: A retrospective study investigated 285 patients with extracranial and intracranial complications among the 2346 inpatients with acute or chronic otitis media with or without cholesteatoma admitted to the Department of Otolaryngology, AnHui Medical University Hospital between 1987 and 2008. Results: In the 285 patients with cranial complications, 253 had a single complication, 29 had... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580175 Sun, 08 Jan 2012 05:00:00 +0100 5580175 http://www.medworm.com/index.php?rid=5580186&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216765%26dopt%3DAbstract Conclusions: These findings suggest that the down-regulation of interleukin (IL)-5 gene expression in collaboration with the suppression of histamine H(1) receptor (H1R) gene expression in the nasal mucosa provides the basis for better therapeutic effects of preseasonal prophylactic treatment with antihistamines in patients with seasonal allergic rhinitis caused by Japanese cedar pollen. Objectives: The effects of prophylactic administration of antihistamines on the expression of IL-5 and IL-33 mRNA in the nasal mucosa of the patients with pollinosis were investigated. Methods: Eight patients had already visited the hospital before the peak pollen period and started preseasonal prophylactic treatment with antihistamines. Seventeen patients who first visited the hospital during the peak pol... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580186 Wed, 04 Jan 2012 05:00:00 +0100 5580186 http://www.medworm.com/index.php?rid=5580185&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216878%26dopt%3DAbstract Authors: López F, Lorente JL, Suárez C Abstract Abstract The patient was a 16-year-old girl complaining about progressive swelling on the right side of her face, right headache, and right orbital proptosis. A CT scan revealed a lytic mass centered in the greater wing of the right sphenoid bone with extension into the orbit, middle cranial fossa, and infratemporal fossa. The patient underwent a subtemporal-preauricular infratemporal fossa approach, which allowed complete resection of the tumor, with a low morbidity. The pathological diagnosis was eosinophilic granuloma. At 36 months after the initial treatment the patient is free of disease. We conclude that lesions of this complex anatomic area are a challenge to biopsy and treat and they could be treated only with radical surge... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580185 Wed, 04 Jan 2012 05:00:00 +0100 5580185 http://www.medworm.com/index.php?rid=5580184&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216898%26dopt%3DAbstract Conclusion: Endoscopic sinus surgery (ESS) treatment has achieved good long-term results in patients in South China with fungal ball rhinosinusitis. Gender (female), age (young), nasal polyps, allergy, high Lund-Mackay scores, prior sinus surgery and diabetes mellitus affect patients' outcomes. Objective: To evaluate objective testing and quality of life (QOL) outcomes of patients with fungal ball rhinosinusitis before and after ESS in South China and to determine preoperative factors that predict surgical outcomes. Methods: We retrospectively analyzed the outcomes for 330 patients with fungal ball rhinosinusitis after ESS. QOL was assessed using Sinonasal Outcome Test-20 (SNOT-20), Short Form-36 (SF-36) questionnaires and visual analogue scale (VAS). Objective testing was evaluated by Lun... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580184 Wed, 04 Jan 2012 05:00:00 +0100 5580184 http://www.medworm.com/index.php?rid=5580182&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22217131%26dopt%3DAbstract Authors: Bloch SL, Sørensen MS Abstract Abstract This paper is a review of our most recent findings concerning the osteo-dynamics of the bony otic capsule and pathogenesis of otosclerosis. By exploring the spatial relationship between normal perilabyrinthine bone remodeling, the viability and spatial distribution of labyrinthine osteocytes, and the location of otosclerosis, a unique spatial pattern emerged. Bone remodeling is highly inhibited around the inner ear space. Most likely, inner ear anti-resorptive signals enter the bony otic capsule through the lacuno-canalicular porosity. The patency of this signaling pathway depends on the viability of individual osteocytes. In the young otic capsule the density of viable osteocytes is high and centripetally distributed. This arrange... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580182 Wed, 04 Jan 2012 05:00:00 +0100 5580182 http://www.medworm.com/index.php?rid=5580181&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22217185%26dopt%3DAbstract Conclusion: Patients with recurrent sudden deafness demonstrating normal vestibular-evoked myogenic potentials (VEMPs) in the lesion ear of the second episode may indicate a good hearing outcome. Objective: This study retrospectively reviewed our experience of patients with recurrent sudden deafness during the past 20 years. Methods: Sixteen (1.4 %) of 1156 patients with sudden deafness were diagnosed as having a recurrent episode, including ipsilateral type in 7 and contralateral type in 9. All patients underwent an audiovestibular test battery and blood and MRI examinations. After 2000, nine patients underwent the VEMP test. Results: In the ipsilateral type, the mean interval between two episodes was 2 ± 2 years, which did not differ significantly from 3 ± 3 years in the contralateral ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580181 Wed, 04 Jan 2012 05:00:00 +0100 5580181 http://www.medworm.com/index.php?rid=5580180&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22217217%26dopt%3DAbstract This report is a reminder that Ménière's disease may also occur in young children. PMID: 22217217 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580180 Wed, 04 Jan 2012 05:00:00 +0100 5580180 http://www.medworm.com/index.php?rid=5580179&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22217261%26dopt%3DAbstract Conclusion: The extended retrolabyrinthine approach (RLA) is a safe and reliable approach for auditory brainstem placement in children. The surgical landmarks to reach cochlear nucleus are adequately exposed by this approach. Objective: To describe a new approach option for auditory brainstem implants (ABIs) in children, highlighting the anatomical landmarks to appropriately expose the foramen of Luschka. Methods: Three prelingually deafened children consecutively operated for ABIs via the RLA. Results: ABI placement via the RLA was successfully performed in all children without any further complications except multidirectional nystagmus in one child. The RLA we employed differed from that used for vestibular schwannoma only in the removal of the posterior semicircular canal. The lateral a... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580179 Wed, 04 Jan 2012 05:00:00 +0100 5580179 http://www.medworm.com/index.php?rid=5580178&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22217320%26dopt%3DAbstract Conclusions: Our preliminary results indicate that mastoidectomy by reconstruction of the posterior wall and obliteration (MAPRO) avoided the disadvantages of a canal-wall-down mastoidectomy. MAPRO effectively prevented cholesteatoma recurrence, provided an excellent basis for hearing restoration, and was generally water-safe. Objective: To evaluate the authors' experience with the MAPRO technique for eradication of cholesteatomas requiring canal-wall-down mastoidectomy. Methods: The medical files of all the patients who underwent MAPRO for cholesteatoma between 2008 and 2011 at the Sheba Medical Center were retrospectively reviewed. Results: This series included 49 patients (31 children and 18 adults). The index operation was the first procedure for 30 patients and repeat surgery for 19 p... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580178 Wed, 04 Jan 2012 05:00:00 +0100 5580178 http://www.medworm.com/index.php?rid=5580177&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22217340%26dopt%3DAbstract Conclusion: The results suggest that the beneficial effect of astragaloside IV on impulse noise-induced hearing loss may be due to its ability to inhibit reactive oxygen species (ROS) and prevent apoptosis. Objective: Astragaloside IV is the major active constituent of Astragalus membranaceus, which has been widely used for the treatment of diseases in China for its antioxidant properties. ROS and apoptosis are involved in damage induced by impulse noise trauma. We aimed to investigate if the beneficial effects of astragaloside IV on cochlea exposed to impulse noise are associated with the inhibition of ROS and the decrease in apoptosis. Methods: 4-Hydroxynonenal (HNE) was used as the marker of ROS. Active-caspase-3 (cas-3) served as a marker for apoptosis. 4HNE and cas-3 were determined i... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580177 Wed, 04 Jan 2012 05:00:00 +0100 5580177 http://www.medworm.com/index.php?rid=5580176&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22217396%26dopt%3DAbstract Conclusions: Upper airway symptoms were common in subjects referred for sleep study. In particular, nasal stuffiness and airway dryness already seemed to bother snorers before development of obstructive sleep apnea syndrome (OSAS). Mouth dryness increased with severity of obstructive sleep apnea (OSA). Objectives: Upper airway symptoms are common in patients with OSAS. However, prevalence of these symptoms is unknown in primary snoring and mild OSA. We evaluated frequency of upper airway symptoms in a large group of patients referred for diagnostic sleep studies. Methods: We examined 524 consecutive subjects (69% men, mean ± SD age 51 ± 12 years, apnea-hypopnea index (AHI) 15 ± 21, body mass index 31 ± 6) by a questionnaire-based survey. The subjects filled in a questionnaire enquiring... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5580176 Wed, 04 Jan 2012 05:00:00 +0100 5580176 http://www.medworm.com/index.php?rid=5538477&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22175306%26dopt%3DAbstract Conclusion: Balance in migraineurs, even in those without vestibular symptoms, deteriorates slightly over 1 year in the most challenging test conditions, when measured with posturography. Objective: To discover by a longitudinal study of a group of migraineurs and their controls, whether the well-known, mild imbalance found on posturography in migraineurs is static or progressive. Methods: Posturographic measures of sway under incrementally more challenging conditions (up to eyes closed standing on a foam surface with the head extended) using the modified clinical test of sensory interaction on balance, limits of stability test, and tandem gait tests in a group of 19 migraineurs and 19 age- and gender-matched controls, all of whom who had been tested over 1 year before. Results: After 1 ye... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5538477 Sun, 25 Dec 2011 08:30:39 +0100 5538477 http://www.medworm.com/index.php?rid=5538476&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22175530%26dopt%3DAbstract Conclusion: The results suggested mercury (Hg)-induced anomalies in the brainstem-mediated acoustic stapedius muscle reflex in children. Objectives: Hg exposure has been associated with hearing impairment and brainstem anomalies. Acoustic stapedius reflex (ASR) thresholds, growth functions, decay/adaptation times, and behavioral auditory thresholds were used to screen Andean children and adults for Hg-induced auditory brainstem and facial nerve impairment. Methods: Fifty-one participants, which included 22 children (aged 6-17 years) and 29 adults (aged 19-83 years) living in gold mining areas of Ecuador where Hg is widely used in amalgamation, were screened using ASR immittance procedures. Results: Mean blood mercury (HgB) level in the children was 15.6 μg/L (SD, 21.3; median, 7 μg/L; ra... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5538476 Sun, 25 Dec 2011 08:30:30 +0100 5538476 http://www.medworm.com/index.php?rid=5538475&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22185213%26dopt%3DAbstract Conclusion: This immunohistochemical study of estrogen and progesterone receptors could not confirm a significant expression in nasal telangiectasias. Thus, a specific effect of these hormones or anti-hormone therapy on malformed nasal vessels has to be questioned and only offered under strict clinical control. Objective: The efforts to control recurrent epistaxis in hereditary hemorrhagic telangiectasia (HHT) using alternative methods are very intense. Hormone or anti-hormone therapy has frequently been postulated and the reported results are controversial. Therefore it was important to find an explanation regarding a possible impact of hormonal therapies by immunohistochemical evaluation of progesterone and estrogen receptor expression on nasal telangiectasias of affected patients. Metho... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5538475 Sun, 25 Dec 2011 08:30:21 +0100 5538475 http://www.medworm.com/index.php?rid=5538474&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22185214%26dopt%3DAbstract Authors: Qin H, Zhao LD, Sun JH, Ren LL, Guo WW, Liu HZ, Zhai SQ, Yang SM PMID: 22185214 [PubMed - in process] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5538474 Sun, 25 Dec 2011 08:30:11 +0100 5538474 http://www.medworm.com/index.php?rid=5427896&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22074105%26dopt%3DAbstract Conclusion: Whilst objective testing on music perception showed no individual differences between cochlear implant (CI) devices, subjective music perception was found to be superior with the MED-EL device in the majority of cases evaluated. Objective: To compare speech and music perception through two different CI systems in the same individuals. Methods: Six post-lingually deaf patients, who had been implanted with a Cochlear(?) Nucleus(?) device in one ear and a MED-EL SONATATI(100) on the contralateral side were evaluated. One subject was excluded from group analysis because of significant differences in performance between ears. Subjects completed a questionnaire designed to assess implant users' listening habits. Subjective assessments of each subject were made for comparison of speec... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427896 Sun, 20 Nov 2011 08:07:08 +0100 5427896 http://www.medworm.com/index.php?rid=5427895&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22074106%26dopt%3DAbstract Conclusions: This follow-up showed a stable and significant decrease in median oxygen desaturation index 4% (ODI(4)) values over the years. Approximately two-thirds of the patients fulfilled the success criteria (ODI(4) reduction of 50% and <20) after 15 years. A majority had improved/cured excessive daytime sleepiness (EDS) and were satisfied. No increased mortality rate was seen. Objectives: To evaluate sleep apnoea recordings and symptoms in patients with obstructive sleep apnoea syndrome 15 years after uvulopalatopharyngoplasty (UPPP) compared to baseline and previous follow-ups. Methods: This was a non-randomized, prospective intervention study on 50 patients who underwent UPPP during 1985?88. Their initial median age was 49 years (range 38?71) and ODI(4) was 26.5 (4?82). Results: ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427895 Sun, 20 Nov 2011 08:06:59 +0100 5427895 http://www.medworm.com/index.php?rid=5427894&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22074107%26dopt%3DAbstract Conclusion: Percutaneous steroid injection (PSI) may be a useful alternative modality for treatment of benign vocal fold lesions. Objectives: When patients refuse general anesthesia or voice therapy for benign vocal fold diseases (Reinke's edema, vocal polyp, nodule, and scarring), there are no other options available. We conducted an analysis of the effects of PSI as an alternative treatment for benign vocal fold diseases. Methods: From October 2008 to March 2010, 130 patients with benign vocal fold disease who refused general anesthesia or showed no response to voice therapy underwent PSI. From this group, the present study included 115 patients who completed the evaluation before PSI and at the first and third month after PSI and also an additional 25 patients who completed evaluation a... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427894 Sun, 20 Nov 2011 08:06:49 +0100 5427894 http://www.medworm.com/index.php?rid=5427900&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22073929%26dopt%3DAbstract Conclusions: The majority of the patients with unilateral auditory neuropathy spectrum disorder (UANSD) were pediatric and mostly showed a great degree of hearing loss when diagnosed. Abnormal auditory brainstem response (ABR) and preserved otoacoustic emissions (OAEs) and/or cochlear microphonics (CM) were important features to differentiate it from common sensorineural deafness and central nerve hearing loss.Objective: To identify the clinical characteristics of patients with UANSD.Methods: This was a retrospective study involving 14 patients diagnosed as having UANSD between 2004 and 2010 in the Chinese PLA Hospital.Results: In all, 50% of the cases were males (1:1 sex ratio) and the average age of onset was 4.1 years. Of the 14 affected ears with UANSD in these cases, 6 were left-sided... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427900 Thu, 10 Nov 2011 05:00:00 +0100 5427900 http://www.medworm.com/index.php?rid=5427899&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22073979%26dopt%3DAbstract Conclusions: Rise time in the estimation of the gravitational vertical in the head tilt response (HTR) test is increased in patients with peripheral vestibular lesions and residual chronic dizziness. Objective: Assessment of the perception of the gravitational vertical in patients with peripheral vestibular lesions through the HTR. Methods: HTR was studied in 12 patients with peripheral vestibular lesion, 8 clinically with chronic dizziness and 4 without it; 23 normal subjects were studied as control group. Two parameters of the HTR were assessed, rise time and steady-state error to characterize a dynamical system step response. The Kolmogorov-Smirnov test (alpha = 5%) was used to verify normal distribution (steady-state error, p = 0.53; rise time, p = 0.88). The three sigma ellipse was ca... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427899 Thu, 10 Nov 2011 05:00:00 +0100 5427899 http://www.medworm.com/index.php?rid=5427898&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22074015%26dopt%3DAbstract Conclusion: The Harmony processor was found to be reliable, comfortable and offered a substantially increased battery life compared with the previous generation processor. No significant improvement in speech understanding with HiRes was demonstrated from objective measures, but the majority of subjects showed a clear subjective preference for the combination HiRes 120/Harmony processor. Objectives: To evaluate experience with the Harmony(?) sound processor, together with the HiRes 120 strategy. Methods: Postlingually deafened adults implanted with a CII or HiRes 90K were included and divided into three groups: (1) experienced users using the Platinum body-worn processor; (2) experienced users who had been using other processors; (3) new users with the Harmony processor from first fitting.... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427898 Thu, 10 Nov 2011 05:00:00 +0100 5427898 http://www.medworm.com/index.php?rid=5427897&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22074053%26dopt%3DAbstract Conclusion: Rhinomanometry is a useful method for evaluating nasal airway patency in schoolchildren, and we could confirm the validity of the results it produces. Objective: Our purpose was to assess the validity nasal resistance measurements produced using anterior active rhinomanometry by comparing the results with those of our previous study and to determine a normal value of the nasal resistance. Methods: Nasal resistance was measured by rhinomanometry in 852 children using the active anterior method. Results: Mean nasal resistance was 0.45 ? 0.70 Pa/cm(3)/s. Nasal diseases were noted in 358 (42%) children, and nasal condition was normal (the normal group) in 494 (58%) children. Nasal resistance was 0.57 ? 1.05 Pa/cm(3)/s in the nasal disease group and 0.35 ? 0.16 Pa/cm(3)/s in the nor... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427897 Thu, 10 Nov 2011 05:00:00 +0100 5427897 http://www.medworm.com/index.php?rid=5427893&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22074449%26dopt%3DAbstract Conclusions: Stapedotomy is, in our opinion, the technique of choice in stapes surgery. The precision of this technique allows clinicians to perform the surgical procedure in day surgery under local anesthesia. Objectives: There is a strong emphasis on increasing the number of elective day surgery cases, especially in the patients? best interest, as it decreases the likelihood of late cancellation and hospital-acquired morbidity. A prospective study was performed to determine whether stapes surgery for otosclerosis could be performed safely in an outpatient setting. Methods: We present a series of stapes surgery cases for otosclerosis performed on a day-case basis. We performed a classic stapedotomy in 9 patients, a reverse classic step stapedotomy in 2 patients, a partial reverse classic ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427893 Thu, 10 Nov 2011 05:00:00 +0100 5427893 http://www.medworm.com/index.php?rid=5427892&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22074488%26dopt%3DAbstract Conclusion: Nocturnal groaning has the same prevalence in patients referred for diagnosis of sleep-disordered breathing as among other populations referred for sleep studies. The respiratory tracings in these patients have a distinct appearance that is possible to recognize with a polygraphic recording and thereby prevent the pattern from being misdiagnosed as central apneas. Objectives: The aim of this study was first to estimate the prevalence of groaning in patients referred for diagnosis of sleep-related breathing disorders. Second, we wanted to describe the respiratory pattern in order to distinguish the patients from patients with sleep apnea. Methods: This was a prospective study in 1004 patients, performed in the Sleep Unit in our ENT Department, during a 12 month period. Results: ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427892 Thu, 10 Nov 2011 05:00:00 +0100 5427892 http://www.medworm.com/index.php?rid=5427891&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22074549%26dopt%3DAbstract Conclusion: Reverse transfer function (RTF) measurement of the Vibrant Soundbridge (VSB) middle ear implant (MEI) is an objective method to evaluate the function of the VSB and can be used to adjust the Connexx value required to reach the optimal VSB gain during fitting sessions. Objectives: To investigate the sound transfer of the VSB with the RTF in implanted patients and evaluate the role of RTF in the fitting process of the VSB. Methods: This was a prospective study including patients undergoing VSB implantation and RTF recording from March 2007 to October 2010. Three parameters were analyzed. 1) RTF: energy transmitted in dB SPL to ear canal by retrograde vibration of malleus and tympanic membrane. 2) Connexx value: level of amplification in dB delivered by the audioprocessor to the f... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427891 Thu, 10 Nov 2011 05:00:00 +0100 5427891 http://www.medworm.com/index.php?rid=5427890&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22074567%26dopt%3DAbstract Conclusions: The -1438G/A polymorphism of 5-HT2A receptor gene may associate with obstructive sleep apnea hypopnea syndrome (OSAHS) in a Chinese Han population. Different genotypes of -1438G/A polymorphism may influence the ventilatory activity in response to hypoxia, and in turn the sleep breath status. Objective: This study was designed to assess the association of polymorphisms in all exons and promoter region of the 5-HT2A receptor gene with OSAHS in a Chinese Han population. Methods: A total of 315 subjects (210 patients and 105 controls) were included for genetic analyses of polymorphisms in all exons and promoter region of the 5-HT2A receptor gene. Results: Six single nucleoside polymorphism (SNP) sites were identified in the sequencing of the promoter and exons of the 5-HT2A recept... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427890 Thu, 10 Nov 2011 05:00:00 +0100 5427890 http://www.medworm.com/index.php?rid=5427907&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22053860%26dopt%3DAbstract Authors: Nomura Y, Kobayashi H Abstract Abstract The aim of this study was to evaluate the effects of argon laser irradiation of the semicircular canals using computed tomography (CT) images and to examine the basis for laser treatment for benign paroxysmal positional vertigo (BPPV). CT images of the posterior canal were evaluated postoperatively in a patient with intractable BPPV, in whom the unilateral posterior and lateral semicircular canals were irradiated with an argon laser. In addition, bootstrap analysis of 20 patients with normal CT findings of the temporal bone was performed and previous experimentally obtained histologic findings were compared. Cross-sections of the posterior canals of 20 patients were found to show no difference in size between the right and left side... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427907 Sun, 06 Nov 2011 04:00:00 +0100 5427907 http://www.medworm.com/index.php?rid=5427906&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22053901%26dopt%3DAbstract Conclusion: The ocular vestibular evoked myogenic potential (o-VEMP) test results correlate significantly with caloric test results for patients with acoustic neuroma (AN), but not for patients with Meniere's disease (MD), indicating that the o-VEMP test may replace the caloric test for evaluating the vestibular nerve from which the AN arises. Conversely, the caloric, o-VEMP, and cervical VEMP (c-VEMP) tests should be performed to map lesion sites in the vestibular labyrinth. Objective: This study performed caloric, o-VEMP, and c-VEMP tests on patients with central and peripheral vestibular disorders to investigate their relationships. Methods: In all, 66 patients comprising 16 with unilateral AN and 50 with unilateral definite MD were enrolled. All patients underwent caloric, o-VEMP, and ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427906 Sun, 06 Nov 2011 04:00:00 +0100 5427906 http://www.medworm.com/index.php?rid=5427905&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22053940%26dopt%3DAbstract Conclusion: A simple measuring box to determine lip-shift angle and eye-width narrowing offered simultaneous and objective data on outcome dysfunction. The method is as easy as visual approaches. The method is objective and as easy as visual access. It is practical for routine clinical use in any clinic. Objectives: The outcome dysfunction after facial paralysis is commonly evaluated by subjective visual access. This paper introduces a new method for simple objective evaluation and grading with documentation of lip-shift and eye-width changes. Methods: Thirty adult controls were used to determine standard deviations (SDs) for angular shift of the lip at rest and eye-width narrowing at maximum lip protrusion. Thirty patients with facial paralysis more than 6 months after onset were studied ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427905 Sun, 06 Nov 2011 04:00:00 +0100 5427905 http://www.medworm.com/index.php?rid=5427904&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22053975%26dopt%3DAbstract Conclusions: Computed tomography (CT) scan with three-dimensional (3D) reconstruction of the inner ear provides a more accurate image of the relationship of the electrode within the cochlear canal, with direct demonstration of electrode insertion depth in the cochlea in comparison with X-ray plain film. Objective: This study was designed to evaluate the value of spiral CT scans with 3D reconstruction in determining the insertion site and depth of implanted cochlear implant electrodes. Methods: A total of 172 cochlear implant recipients were involved in this study. The implanted electrodes of all patients were examined by X-ray plain film, and 157 cochlear recipients were examined by spiral CT scans with axial 1 mm image slices. The data from the CT scans were transferred to a workstation f... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427904 Sun, 06 Nov 2011 04:00:00 +0100 5427904 http://www.medworm.com/index.php?rid=5427903&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22054020%26dopt%3DAbstract Conclusions: We suggest that age-induced changes of serotonin, N-methyl-d-aspartate receptor (NMDAR), and glutamate decarboxylase (GAD) expression in rats are dependent on the specific location in the central auditory system (CAS). Objectives: Despite the importance of understanding changes in neurotransmitters during presbycusis, only a few studies have assessed age-associated changes in neurotransmitter at each level of the CAS. We therefore evaluated effects of aging on neurotransmission in the CAS of rats. Methods: The concentrations of serotonin, NMDAR, and GAD were assayed immunohistochemically in the cochlear nucleus (CN), superior olivary nucleus (SON), inferior colliculus (IC), medial geniculate body (MGB), and auditory cortex (AC) of Sprague-Dawley rats, aged 2 weeks (n = 20) or ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427903 Sun, 06 Nov 2011 04:00:00 +0100 5427903 http://www.medworm.com/index.php?rid=5427902&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22054051%26dopt%3DAbstract Conclusions: A final incidence of bilateral involvement was 20.7%. Episodic spells of vertigo were completely controlled in 23 of 29 patients, while 11 of 29 patients demonstrated over 70 dB hearing loss. Objective: To analyze the clinical course of 29 patients with Meniere's disease during follow-up of 10 years or more. Methods: The subjects were 29 patients with a mean follow-up of 18.3 years. The hearing level was measured by the pure tone average (PTA) of four frequencies at the initial and the final examination, and it was classified into four categories according to the American Academy of Otolaryngology-Head and Neck Society (AAO-HNS) criteria. The control of vertigo was evaluated by the modified AAO-HNS criteria. Results: At enrolment two patients had bilateral involvement. In the ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427902 Sun, 06 Nov 2011 04:00:00 +0100 5427902 http://www.medworm.com/index.php?rid=5427901&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22054073%26dopt%3DAbstract Conclusions: There has been a reduction in the number of modified radical mastoidectomy and revision mastoidectomy surgeries per head of population in Ontario between 1987 and 2007, we believe that this represents a true reduction in prevalence of cholesteatoma. The increase of cases performed at the University Hospital Network, Toronto (UHN) may represent a shift to subspecialization in the treatment of chronic ear disease. Objective: To analyze the trends in mastoid operations for chronic middle ear disease in the Canadian province of Ontario between 1987 and 2007 and to determine whether an increasing proportion of these procedures are being performed in tertiary referral centres. Methods: The year on year population and number of mastoid procedures performed per year in Ontario and at ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5427901 Sun, 06 Nov 2011 04:00:00 +0100 5427901 http://www.medworm.com/index.php?rid=5302010&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970786%26dopt%3DAbstract Conclusion: Low plasma melatonin is significant in the development of high frequency hearing loss (HL) among the elderly. Objective: To determine the correlation between hearing threshold and the plasma melatonin and ascorbic acid (vitamin C). Methods: This was a cross-sectional study involving 126 apparently healthy elderly subjects, 59 males and 67 females, aged >60 years. Subjects underwent pure tone audiometry and plasma melatonin and vitamin C were assayed using high-performance liquid chromatography. Results: The mean ± SD of plasma melatonin among the subjects with normal hearing (NH) (0-30 dB) and those with HL in the speech frequencies was 18.3 ± 3.6 μg/L and 16.4 ± 4.7μg/L, respectively. In the high frequencies the values were 17.7 ± 6.2 μg/L and 13.1 ± 6.4μg/L for NH... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5302010 Mon, 10 Oct 2011 13:20:22 +0100 5302010 http://www.medworm.com/index.php?rid=5302009&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970787%26dopt%3DAbstract Conclusion: We studied the compound action potential (AP) recovery from adaptation (AP recovery) in idiopathic sensorineural hearing loss (iSSNHL). Abnormal AP recovery was demonstrated in 15 of 45 patients, consisting of increased recovery (iR) over the normal range in 11 ears and decreased recovery (dR) under the normal range in 4 ears. The mechanisms for occurrence and clinical significance of these phenomena are currently unknown. Objectives: The purpose of this study was to investigate the pathologic features of AP recovery in iSSNHL. Methods: Forty-five subjects with iSSNHL were enrolled and 18 normal-hearing subjects participated to assess the normal range of AP recovery. Equilevel paired clicks with inter-click interval from 5 to 100 ms were applied as acoustic stimuli. Results: El... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5302009 Mon, 10 Oct 2011 13:20:12 +0100 5302009 http://www.medworm.com/index.php?rid=5221562&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21895417%26dopt%3DAbstract Conclusions: In our experience, the technique described can be applied independently according to the specific patient's anatomy and disease, allowing simple, easy, and safe identification of the anterior ethmoidal artery (AEA). Objectives: The aim of this study was to provide the anatomic rationale for endoscopic cauterization of the AEA and to present our surgical approach to AEA in the treatment of severe nasal bleeding. Methods: A retrospective study reviewed 300 endoscopic transnasal AEA cauterizations, over a 20-year period from 1991 to July 2010, at the Instituto Felippu, Sao Paolo, Brazil. All surgeries were carried out under general anesthesia and with the help of a rigid 30° endoscope. Results: The AEA was identified in all the patients treated. In 299 patients we found the AEA ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5221562 Thu, 15 Sep 2011 23:21:13 +0100 5221562 http://www.medworm.com/index.php?rid=5221556&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905959%26dopt%3DAbstract Conclusion: Power-assisted turbinectomy is a safe and reliable alternative for patients with nasal blockage if nasal corticosteroid spray therapy is not suitable. Objective: Powered-assisted partial turbinectomy was compared to the use of a corticosteroid nasal spray for relief of nasal obstruction in chronic or idiopathic rhinosinusitis. Methods: Patients were randomized to either power-assisted partial turbinectomy or daily use of mometasone furoate nasal spray for 6 months. Evaluation by peak nasal inspiratory flow (PNIF) and grading of symptoms by use of visual analog scale was done after 3 and 6 months. Grading of symptoms was also done by use of a questionnaire approximately 30 months after the last visit. Results: PNIF scores improved for all patients, although significantly only fo... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5221556 Mon, 12 Sep 2011 04:00:00 +0100 5221556 http://www.medworm.com/index.php?rid=5221555&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905960%26dopt%3DAbstract Conclusion: Cochleostomy is the most efficient approach in delivering PEG-b-PCL polymersomes (PMs) to the inner ear. PMs can be delivered to the vestibule by transtympanic injection or cochleostomy. Objective: To evaluate the efficiency of delivering PEG-b-PCL PMs into the inner ear using different approaches. Methods: The PEG-b-PCL PMs were administered either by sustained topical round window membrane (RWM) delivery using gelatin sponge pledgets in combination with an osmotic pump, transtympanic injection, or cochleostomy. The distribution of the PMs in the inner ear was observed by confocal microscopy using either whole mount specimens or cryosections. Results: Cochleostomy resulted in distribution of the PMs in the spiral ligament (SL), mesothelial cells beneath the organ of Corti, sup... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5221555 Mon, 12 Sep 2011 04:00:00 +0100 5221555 http://www.medworm.com/index.php?rid=5221561&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905791%26dopt%3DAbstract Conclusions: The safety of treatment with palatal implants remains high 3 years after the procedure. The implant extrusion rate decreases over time. Additional surgery to the palate is safe. The presence of the implants seems important in sustaining efficacy past 1 year. Objectives: To investigate long-term safety and treatment results of palatal implants for treatment of snoring. Methods: A prospective clinical non-randomized trial of 55 patients with primary snoring followed over a period of 3 years. Results: No major adverse events were observed. Eleven of the 55 patients (20%) experienced implant extrusions, 8 during the first year, 3 in the second, and none in the third year. Twenty-six patients (47.3%) had additional procedures past 1 year. Only one post-implant surgery caused an ext... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5221561 Fri, 09 Sep 2011 04:00:00 +0100 5221561 http://www.medworm.com/index.php?rid=5221560&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905792%26dopt%3DAbstract Conclusion: Betahistine dihydrochloride, a drug used widely in the systemic treatment of balance disorders such as Ménière's disease, was found to improve eustachian tube function when applied topically in the nasopharynx of rats. Objectives: The study tested the effect of betahistine, a histamine receptor agonist, on eustachian tube function and tested the involvement of H1 and H3 histamine receptors. Methods: Eustachian tube function was measured in anaesthetized rats while middle ear pressure was increased and then monitored during induced swallowing. Betahistine and other drugs were applied topically in the nasopharynx, bulla and epipharynx, and administered intraperitoneally. Results: Systemic application of betahistine hardly changed eustachian tube function, but topical applicatio... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5221560 Fri, 09 Sep 2011 04:00:00 +0100 5221560 http://www.medworm.com/index.php?rid=5221559&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905793%26dopt%3DAbstract Conclusion: Even though the use of TachoComb does not decrease pain after tonsillectomy, it is safe and useful to reduce bleeding after tonsillectomy. Objectives: Sealing the post-tonsillectomy wound would be expected to reduce pain and bleeding by decreasing the exposure of the traumatized tissue and sensory nerves. TachoComb is a powerful topical hemostatic agent. The objectives of this study were to evaluate the effect of TachoComb on reduction of pain and bleeding after tonsillectomy. Methods: A prospective randomized double-blind study was performed on 120 pediatric patients undergoing adenotonsillectomy. The patients were randomized into two groups: use/non-use of TachoComb. In the study group, each tonsillar bed was covered with a TachoComb strip at the end of operation. No hemostat... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5221559 Fri, 09 Sep 2011 04:00:00 +0100 5221559 http://www.medworm.com/index.php?rid=5221558&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905794%26dopt%3DAbstract Authors: Coca-Pelaz A, Llorente-Pendás JL, Vivanco-Allende B, Suárez-Nieto C Abstract Abstract The patient was a 48-year-old man complaining about right hemicranial pain and deafness of 1 year's duration. MRI showed a solid well-vascularized mass destroying the mastoid and petrous bone, and with an epidural component that pulled the right cerebellar hemisphere. The patient underwent a right modified type A infratemporal approach, which allowed complete resection of the tumor, with a low morbidity. The pathological diagnosis was solitary fibrous tumor. The patient received complementary treatment with radiotherapy. At 24 months after the initial treatment the patient is free of disease. We conclude that solitary fibrous tumor of the petrous bone can be satisfactorily treated with ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5221558 Fri, 09 Sep 2011 04:00:00 +0100 5221558 http://www.medworm.com/index.php?rid=5221557&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21905795%26dopt%3DAbstract Conclusion: The prediction of subtype and the affected ear of benign paroxysmal positional vertigo (BPPV) derived from the answers to our questionnaire can support the definitive diagnosis of BPPV. Objectives: We examined to what extent the diagnosis of subtype and the affected ear of BPPV judged from answers to a questionnaire agreed with the diagnosis decided by the results of the positional nystagmus test. Methods: We asked the following questions: 'What kind of head movements induce vertigo?' and 'How long does the vertigo continue?'. As for the affected ear, we asked which ear was lower during stronger vertigo when induced in a supine position or during sleep. Results: The percentages of correct diagnosis speculated by the combined answers were 69% in posterior canal-type BPPV, 48% in... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5221557 Fri, 09 Sep 2011 04:00:00 +0100 5221557 http://www.medworm.com/index.php?rid=5221563&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21892900%26dopt%3DAbstract Conclusion: The chewing gum indirectly affects postural control by influencing vestibular function to stabilize posture during upright standing. Objectives: This study aimed to evaluate the effect of chewing gum on static posturography in patients. Methods: The subjects were 26 patients with chronic balance disorders. The subjects were instructed to stand as stably as possible on the force platform. The recording was conducted four times. For the first evaluation, postural sway was measured during motionless standing. Two weeks after the recording, the postural sway was recorded again as a second evaluation. Thereafter, the subjects were instructed to chew gum for 3 min. The third evaluation was conducted while the subjects continued to chew gum. Then 1 h after the subject had stopped chew... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5221563 Tue, 06 Sep 2011 04:00:00 +0100 5221563 http://www.medworm.com/index.php?rid=5221565&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21888565%26dopt%3DAbstract Conclusion: The findings suggest that underwater sound perception is realized by the middle ear rather than by bone conduction, at least in shallow water conditions. Objective: To prove whether underwater sound perception is effected by bone conduction or by conduction via the middle ear. Methods: Five divers, breathing through snorkels, were tested in a swimming pool, to determine whether a sound was louder when the acoustic source placed was in front of the head in comparison with a lateral application facing the ear region. The second experiment investigated whether sound perception is influenced by ear protection plugs in underwater conditions. Also, the effect of a 5 mm thick neoprene hood was determined, with and without an additional perforation in the ear region. Results: Sounds we... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5221565 Mon, 05 Sep 2011 04:00:00 +0100 5221565 http://www.medworm.com/index.php?rid=5221564&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21888566%26dopt%3DAbstract We report three cases of retropharyngeal node metastasis from thyroid papillary carcinoma, including a case of bilateral nodal metastasis. Retropharyngeal node metastasis was successfully resected in all three patients by the transcervical approach. As pointed out in past reports, this report also suggests that prior neck dissection and/or metastasis to cervical lymph nodes might alter the direction of lymphatic drainage to the retrograde fashion, resulting in the unusual metastasis to the retropharyngeal lymph nodes, and there is a possibility of a bilateral pattern. Also, it is necessary to consider the possibility of metastasis from a papillary thyroid carcinoma in the differential diagnosis of lymph node swelling in the parapharyngeal space. PMID: 21888566 [PubMed - as supplied by ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5221564 Mon, 05 Sep 2011 04:00:00 +0100 5221564 http://www.medworm.com/index.php?rid=5142740&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21838614%26dopt%3DAbstract Conclusion: There was no significant difference in the postoperative outcomes between different surgical options for treating chronic maxillary sinusitis (CMS). Objective: We aimed to compare the improvement in symptoms, and changes in endoscopic and CT grade in patients undergoing different surgical management of the maxillary sinus ostium. Methods: In 32 patients (group A), the pathologic mucosa was radically removed with a power microdebrider. In 28 patients (group B), only part of the pathologic mucosa was removed; gross pathologic lesions were left in situ. In 38 patients (group C), only enlargement of the maxillary ostium was performed. Pre- and postoperative changes in symptoms, endoscopic polyp grade, and Lund-Mackay CT score were compared between groups. Results: In all groups, th... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5142740 Sat, 20 Aug 2011 11:22:15 +0100 5142740 http://www.medworm.com/index.php?rid=5142739&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21846295%26dopt%3DAbstract Conclusions: When used to test 3-year-old children within 3 months of tympanostomy tube placement for recurrent acute otitis media (rAOM) or chronic otitis media with effusion (cOME) the forced response test (FRT) showed relatively minor differences in the active and passive functions of the eustachian tube. While the sample size was small, the high variability in all test parameters suggests that the FRT alone is not capable of distinguishing between children with different expressions of otitis media. Objective: The FRT was designed to measure the passive and active properties of the eustachian tube. We evaluated the ability of that test to discriminate groups of children with rAOM or cOME. Methods: Twenty-two ears (15 children) with a confirmed history of rAOM and 24 ears (17 children) ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5142739 Tue, 16 Aug 2011 23:00:00 +0100 5142739 http://www.medworm.com/index.php?rid=5142738&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21846296%26dopt%3DAbstract Conclusion. Maxillary sinus abnormalities were demonstrated to be associated with maxillary sinus infundibulum narrowing as well as nasal airflow resistance secondary to nonspecific nasal inflammation. Objectives. There is no consensus regarding the pathogenetic roles of allergy and anatomic variations in sinus mucosa abnormalities. We investigated the correlation between allergy and anatomic variations in sinus abnormalities in chronic rhinitis patients in the presence or absence of allergy. Methods: In all, 148 adult patients with allergic rhinitis (AR) and non-allergic rhinitis (NAR) were enrolled. Opacification of sinuses, the size of the maxillary sinus infundibulum, Haller cells, and concha bullosa were evaluated based on computed tomography (CT) images. Simultaneously, nasal airflow... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5142738 Tue, 16 Aug 2011 23:00:00 +0100 5142738 http://www.medworm.com/index.php?rid=5142745&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21838604%26dopt%3DAbstract Conclusion. Neither elective selective neck dissection nor any conservative treatment option in pT2cN0 glottic cancer showed a significant advantage on survival. This should be the basis for future treatment standardization. Obligatory documentation of the R status and cause of death in the cancer registries will improve the data interpretation in the future. Objectives. Optimal adjuvant treatment of pT2cN0 glottic cancer is not well defined. The impact of neck dissection or radio(chemo)therapy for better outcome is unknown. Methods: In a retrospective cancer registry study we analyzed the survival of 73 patients with pT2cN0 glottic cancer in Thuringia, Germany, treated surgically between 1996 and 2005. Results: In all, 35 patients had undergone elective neck dissection, the remaining 38 p... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5142745 Sun, 14 Aug 2011 23:00:00 +0100 5142745 http://www.medworm.com/index.php?rid=5142744&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21838605%26dopt%3DAbstract Authors: Ding Y, Leng J, Zheng J PMID: 21838605 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5142744 Sun, 14 Aug 2011 23:00:00 +0100 5142744 http://www.medworm.com/index.php?rid=5142743&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21838606%26dopt%3DAbstract Conclusion. Bone marrow mesenchymal stem cells (MSCs) have the ability to differentiate into hair cells, and this method of culturing MSCs provides a useful tool for studies on mammalian cochlear hair cell regeneration. Objective: To investigate a method to induce bone marrow MSCs to differentiate into inner ear hair cells. Methods: Rat bone marrow MSCs were isolated from healthy rats and cultured in vitro. To make sure that the cultured cells were bone marrow MSCs, the expression of MSC markers such as SH2, CD31, CD34, and CD44 genes on the cultured cells was assessed by RT-PCR. Adipogenic cells and osteogenic cells were induced by the differentiation of the cultured cells, respectively, suggesting that the cultured cells have the characteristic of pluripotent differentiation. Then they w... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5142743 Sun, 14 Aug 2011 23:00:00 +0100 5142743 http://www.medworm.com/index.php?rid=5142742&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21838607%26dopt%3DAbstract Conclusion. Middle ear pressure treatment by the tympanic membrane massage (TMM) device as well as the Meniett device is effective and provides minimally invasive options for intractable vertigo in patients with Meniere's disease (MD) and delayed endolymphatic hydrops (DEH). Objective: The effects of the TMM device were evaluated according to the criteria of the Japan Society for Equilibrium Research (1995) in patients with MD and DEH and compared to those in patients treated with the Meniett device. Methods: Twelve ears of 10 patients (MD 8; DEH 2) were treated with the TMM device, while 16 ears of 15 patients (MD 11; DEH 4) were treated with the Meniett device. All the patients had failed to respond to medical treatment including diuretics before each pressure treatment, and were followe... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5142742 Sun, 14 Aug 2011 23:00:00 +0100 5142742 http://www.medworm.com/index.php?rid=5142741&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21838608%26dopt%3DAbstract Conclusion. In our experience, fine needle aspiration cytology (FNAC) combined with immunocytochemistry/flow cytometry in the investigation of lymphoma presenting in the neck is highly valuable. In our unit it has a sensitivity of 95.5% and a positive predictive value (PPV) of 96.8% and is the first-line investigation in suspected lymphoma. It enables planning of radiological and haematological investigations and obviates panendoscopy as part of the staging protocol. Objective: Lymphoma commonly presents to otolaryngologists. The aim of our study was to evaluate the accuracy of FNAC in lymphoma presenting in the neck at our institute. Methods: Data were collected retrospectively between 2003 and 2007. Separate searches for cytological and histopathological diagnosis of lymphoma on cervical... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5142741 Sun, 14 Aug 2011 23:00:00 +0100 5142741 http://www.medworm.com/index.php?rid=5111737&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21762004%26dopt%3DAbstract Conclusion: The Japanese version of the Dizziness Handicap Inventory (DHI) is a reliable, comprehensively validated, and clinically useful tool to measure self-perceived handicap associated with dizziness. Objectives: The DHI is a useful instrument to document the consequences of vestibular and/or balance impairment. A Japanese version of this self-assessment inventory is needed to evaluate the handicapping effects imposed by vestibular system disease in Japanese patients. The purpose of this study was to determine the internal consistency of the reliability of the Japanese version of the DHI. Methods: We recruited 176 patients between January and September 2008 from the outpatients of the Department of Otolaryngology, Hino Municipal Hospital, Japan. The DHI was translated into Japanese, a... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5111737 Sun, 31 Jul 2011 23:00:00 +0100 5111737 http://www.medworm.com/index.php?rid=5111738&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21756022%26dopt%3DAbstract Conclusion. Noise levels sufficient to cause sensorineural hearing loss can be measured when electrical drills and suction are used during otological surgery, particularly if a running burr touches the endosteal membrane of the otic capsule. Our noise measurements confirm the theory that 'soft surgery' should be employed during otological surgery, with focus on reduction of noise exposure. Objective: To investigate noise levels generated by otological electrical drills and suction. Methods: Airborne noise levels generated by different drills and suction tips of different diameters were evaluated in 12 fresh isolated human temporal bones by means of an ER7C probe microphone system. Results: Noise levels ranged from 120 to 122 dB SPL during drilling in cortical bone and from 117 to 121 dB SP... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5111738 Wed, 13 Jul 2011 23:00:00 +0100 5111738 http://www.medworm.com/index.php?rid=5018984&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21736516%26dopt%3DAbstract Conclusion: The cochlear implant was beneficial as an attempt to restore hearing and improve communication abilities in this patient with profound sensorineural hearing loss secondary to Susac syndrome. Objective: To report the audiological outcomes of cochlear implantation (CI) in a young woman with Susac syndrome after a 6-month follow-up period. Susac syndrome is a rare disorder. It is clinically characterized by a typical triad of sensorineural deafness, encephalopathy, and visual defect, due to microangiopathy involving the brain, inner ear, and retina. Methods: This was a retrospective review of a case at a tertiary referral center. After diagnosis, the patient was evaluated by a multidisciplinary team and received a cochlear implant in her right ear. Results: The patient achieved 10... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5018984 Thu, 07 Jul 2011 23:00:00 +0100 5018984 http://www.medworm.com/index.php?rid=5018987&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732742%26dopt%3DAbstract Conclusion: MASPIN subcellular location can be considered a prognostic marker that is potentially useful for identifying elderly patients with laryngeal carcinoma at higher risk of early loco-regional recurrence, who may benefit from more aggressive therapy. In a targeted treatment setting, re-activated nuclear MASPIN in combination with anti-angiogenic and/or cytotoxic drugs may be effective in treating laryngeal carcinoma in elderly patients. Objectives: Aging is associated with molecular, cellular, and physiological changes that influence carcinogenesis and cancer growth. MASPIN has multifaceted anti-tumor effects and available evidence supports the hypothesis that its subcellular location influences its functions. The aim of the present study was to firstly assess the potential prognos... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5018987 Tue, 05 Jul 2011 23:00:00 +0100 5018987 http://www.medworm.com/index.php?rid=5018986&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732743%26dopt%3DAbstract Conclusion: Injection of injured rabbit vocal folds with human adipose-derived stem cells (hADSCs) led to improved wound healing and fewer signs of scarring as demonstrated by a decreased collagen content in the treated folds compared with the untreated folds. hADSCs remained viable for up to 12 weeks in rabbit vocal folds. Objective: The aim of this study was to investigate the morphologic and histologic properties of scarred rabbit vocal folds following injection of hADSCs. Methods: This was a randomized, controlled animal study. Twenty-four vocal folds from 12 New Zealand rabbits were scarred using a CO(2) laser and injected with either hADSCs (left vocal fold) or phosphate-buffered saline (right vocal fold). Every 4 weeks for the first 12 weeks after injection, an endoscopic examinatio... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5018986 Tue, 05 Jul 2011 23:00:00 +0100 5018986 http://www.medworm.com/index.php?rid=5018985&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732744%26dopt%3DAbstract Conclusion. Imaging of the endolymphatic space was possible in most cases after administering a standard dose of gadolinium (Gd) by using heavily T2-weighted 3D fluid-attenuated inversion recovery (hT(2)W-3D-FLAIR) magnetic resonance imaging (MRI). Objectives. The aim of this study was to characterize the contrast enhancement in the inner ear after intravenous injection of Gd and to compare the signal intensity after a double dose or standard dose of Gd. Methods: We injected a standard dose of gadodiamide hydrate (DTPA-BMA) or a double dose of gadoteridol (HP-DO3A) intravenously in patients affected by Meniere's disease and performed hT(2)W-3D-FLAIR 3 T MRI. Contrast enhancement of the basal turn of the cochlea was evaluated semiquantitatively. Results: Endolymphatic hydrops was observed i... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5018985 Tue, 05 Jul 2011 23:00:00 +0100 5018985 http://www.medworm.com/index.php?rid=5018991&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21728749%26dopt%3DAbstract Authors: Angeli RD, Ammar MB, Sanna M PMID: 21728749 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5018991 Mon, 04 Jul 2011 23:00:00 +0100 5018991 http://www.medworm.com/index.php?rid=5018990&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21728750%26dopt%3DAbstract Conclusion: The occult metastasis rate for T2 oral cancer can be reduced by ultrasonography (US). Also, the late metastasis rate is considered to be reduced by combining US with frozen section biopsy (FSB) during supraomohyoid neck dissection (SOHND). Objectives: Early oral cancer has been reported to show occult metastases in 15-53% of patients, but the criteria or methods for the diagnosis of cervical lymph node metastasis are unclear in many studies, and there is no clear definition of occult metastasis. In patients with T2 oral cancer, the diagnosis of lymph node metastasis by US and its pathological diagnosis (pN) after neck dissection were compared to evaluate the usefulness and limitations of US, occult metastasis rate, significance of SOHND as preventive neck dissection, and use of... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5018990 Mon, 04 Jul 2011 23:00:00 +0100 5018990 http://www.medworm.com/index.php?rid=5018989&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21728751%26dopt%3DAbstract Conclusion. The recurrence rate of vertigo due to any cause in patients with vestibular neuritis (VN) was about 26.0% in our study. No clinical characteristics were significantly associated with recurrences. Objective: We aimed to: 1) determine the prevalence of recurrent VN; 2) compare the clinical characteristics and epidemiologic factors of patients with non-recurrent and recurrent VN; and 3) determine the prevalence of benign paroxysmal positional vertigo (BPPV) in patients with VN. Methods: In 131 patients diagnosed as having VN (68 males, aged 49.8 ± 14.9 years and 63 females, aged 57.5 ± 12.5 years), a retrospective chart review and telephone survey about the recurrent vertigo were performed. Vestibular function testing, inner ear magnetic resonance imaging (MRI), and pure tone au... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5018989 Mon, 04 Jul 2011 23:00:00 +0100 5018989 http://www.medworm.com/index.php?rid=5018988&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21728752%26dopt%3DAbstract Conclusion. We have demonstrated differences in cortical activation with language-related visual stimuli in patients who were profoundly deafened due to genetic mutations in GJB2 and SLC26A4. The differences in cortical processing patterns between these two cases may have been influenced by the differing clinical courses and pathogenesis of hearing loss due to genetic mutations. Our results suggest the importance of hearing during early childhood for the development of a normal cortical language network. Objectives. To investigate the cortical activation with language-related visual stimuli in patients who were profoundly deafened due to genetic mutations in GJB2 and SLC26A4. Methods: The cortical activity of two adult patients with known genetic mutations (GJB2, SLC26A4) was evaluated wit... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5018988 Mon, 04 Jul 2011 23:00:00 +0100 5018988 http://www.medworm.com/index.php?rid=5018992&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21711214%26dopt%3DAbstract Conclusion: In cases of petrous apex (PA) cholesteatoma, radical removal should be prioritized over an unreasonable sparing of hearing or facial symmetry. Nevertheless, for patients with serviceable hearing and spared inner ear structures, conservative approaches may be applicable. Restoration of facial nerve (FN) function is achievable by reanimation procedures. Objectives: To analyze clinical manifestations, surgical techniques, and postoperative functional results of PA cholesteatoma. Methods: From 1987 to 2010, 13 cases of PA cholesteatoma underwent operations. Clinical, audiological, and radiological findings, surgical approach, and postoperative functional outcomes were analyzed retrospectively. Results: The most common symptoms were hearing loss and FN paralysis. All PA cholesteatom... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=5018992 Tue, 28 Jun 2011 23:00:00 +0100 5018992 http://www.medworm.com/index.php?rid=4971153&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21696256%26dopt%3DAbstract Conclusion: This was the first study to specifically demonstrate the validity of ablative surgery and free flap reconstruction for elderly patients with oral or oropharyngeal cancer in terms of oncologic and functional outcomes. Objective: The aim of our study was to evaluate the impact of advanced age on oncologic and functional outcomes after ablative surgery and free flap reconstruction in patients with oral or oropharyngeal cancer. Methods: We conducted a retrospective review of the medical records of all patients who underwent ablative surgery and reconstruction with free flap for primary oral or oropharyngeal cancer at our institution between 2000 and 2009. The impact of advanced age (≥70 years) on oncologic and functional outcomes was assessed in univariate and multivariate analys... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4971153 Tue, 21 Jun 2011 23:00:00 +0100 4971153 http://www.medworm.com/index.php?rid=4971152&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21696257%26dopt%3DAbstract Conclusions: The cochlin-tomoprotein (CTP) detection test can be used to make a definite, objective diagnosis of traumatic perilymphatic fistula (PLF), and therefore offers valuable information on patient selection for surgical treatment. Objectives: Penetrating middle ear injury can cause traumatic PLF, which is a surgically treatable otologic emergency. Recently, we have reported on CTP, a novel perilymph-specific protein. The purpose of this study was to determine if the CTP detection test is useful for the diagnosis of traumatic PLF. Methods: This was a prospective study of CTP detection in penetrating middle ear injury cases with tympanic membrane perforation and hearing loss. Results: A total of seven individuals were included in this study. CTP was detected in three of four cases wi... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4971152 Tue, 21 Jun 2011 23:00:00 +0100 4971152 http://www.medworm.com/index.php?rid=4922729&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21651316%26dopt%3DAbstract Conclusion. Consecutive daily low-dose S-1 therapy was less toxic and its efficacy was not inferior to the conventional administration schedule. Consecutive daily low-dose S-1 chemotherapy appears to be a treatment option for patients in whom it is difficult to continue the conventional administration schedule of S-1 due to adverse events. Objective: To evaluate the safety and efficacy of consecutive daily low-dose S-1 therapy in an adjuvant setting. Methods: This study investigated 52 patients with absence of local residual tumor, lymph node metastasis or distant metastasis after radical treatment for advanced head and neck squamous cell carcinoma. After receiving informed consent from patients, half of the usual dose of S-1 was administered daily for 2 years. The safety, feasibility, and... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4922729 Tue, 07 Jun 2011 23:00:00 +0100 4922729 http://www.medworm.com/index.php?rid=4922728&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21651317%26dopt%3DAbstract Conclusion. CD34-positive mesenchymal tissues are likely to play a critical role in the pattern formation of laryngeal and pharyngeal walls. In the ear, nose, and throat regions, a future clinical relevance may be found in their use for muscle repair and regeneration. Objectives. CD34 is a well-known marker of progenitor cells of blood vessels and stromal tissues. Thus, CD34-positive cells have recently been used clinically in the field of vascular and orthopedic biotechnology because of their capacity to assist regeneration of injured tissues. However, to our knowledge, the in situ distribution of CD34-positive cells has not yet been described in the human fetus, with the exception of a few organs. The purpose of this study was to describe the location of CD34-positive cells in the head a... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4922728 Tue, 07 Jun 2011 23:00:00 +0100 4922728 http://www.medworm.com/index.php?rid=4922727&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21651318%26dopt%3DAbstract Conclusions: There could be another candidate gene in DFNA2, which could be responsible for the hearing loss phenotype. Objective: We collected a four-generation family from the southern part of China with autosomal dominant sensorineural hearing impairment. In order to identify the responsible pathogenic mutations in this family, we set out to identify the locus and to sequentially analyze the candidate genes in the identified region. Methods: After family ascertainment and clinical analysis, exclusive analysis was performed. Then a genome-wide scan was performed using an Illumina Linkage-12 DNA Analysis Kit (average spacing 0.58 cM). Fine-mapping markers were genotyped to identify the locus. Finally, we performed haplotype analyses and candidate gene DNA sequencing for the family. Result... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4922727 Tue, 07 Jun 2011 23:00:00 +0100 4922727 http://www.medworm.com/index.php?rid=4922734&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631176%26dopt%3DAbstract Conclusion. When excessive height loss occurs in the elderly, which may be indicated by a cervical-bent posture, examination of the head and neck should be performed to detect common carotid artery (CCA) and internal carotid artery (ICA) aberration. In such cases brain magnetic resonance imaging (MRI) examination should be conducted to determine whether infarction is present. Objectives. To examine the relationships among bent posture, height loss, aberration of carotid arteries, and ischemic stroke risk with a case-control study. Methods: Controls (n = 163) were selected from among patients who had undergone MRI of the brain because of otolaryngologic symptoms. Case patients (n = 72) were selected from among those whose primary diagnosis was cerebral infarction in the area served by the I... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4922734 Tue, 31 May 2011 23:00:00 +0100 4922734 http://www.medworm.com/index.php?rid=4922733&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631177%26dopt%3DAbstract Conclusion. Our results raise the question as to whether specific patterns of 'germline loss of heterozygosity (LOH)' could contribute to the genetic susceptibility for head and neck squamous cell carcinoma (HNSCC). Objectives. HNSCC usually occurs in older individuals with a history of smoking. However, about 5% of HNSCC patients have never used tobacco or develop this disease at an exceptionally young age. Therefore, genetic susceptibility must contribute significantly to HNSCC risk. The objective was to introduce a novel approach that might help to unveil candidate genes contributing to cancer predisposition and to identify individuals at risk for HNSCC, and to present our observations with this method in a specific group of patients. Methods: High-resolution SNP (single-nucleotide poly... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4922733 Tue, 31 May 2011 23:00:00 +0100 4922733 http://www.medworm.com/index.php?rid=4922732&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631178%26dopt%3DAbstract Conclusion. Our data suggest that the changes in expression of antioxidant enzymes may cause age-related hearing loss (AHL). Objectives. AHL is an aging process of the inner ear, and oxidant stressors are considered to be one of the leading causes. We investigated the hearing level and expression profile of antioxidant enzymes in aged mice. Methods: Mice aged 3, 6, and 11 months were used. Hearing levels of the mice were examined using the auditory brainstem response (ABR). After measuring the ABR threshold, cochleae were dissected. RNA was isolated from the cochleae, and cDNA was synthesized using the retro-transcription enzyme. Expression of the antioxidant enzymes was measured by quantitative real-time PCR. Results: The ABR thresholds of the BDF1 mice were elevated by 6 months of age. T... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4922732 Tue, 31 May 2011 23:00:00 +0100 4922732 http://www.medworm.com/index.php?rid=4922731&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631179%26dopt%3DAbstract Authors: Wang Q, Zhao FF, Shi YB Abstract Syndromic hearing impairment encompasses hundreds of phenotypes. We identified a young female patient affected by the unique combination of dysplasia of the auricular system, patent ductus arteriosus (PDA), choroideremia, and enamel hypoplasia. The patient was treated with PDA ligature and left exploratory tympanotomy. Impairment in all four systems suggests a correlation with the neural crest. It is presumed that all of the features result from the same origin, probably through autosomal recessive inheritance or a novel mutation during the embryonic period. When audio-dento-oculo-cardio systems are involved, we suggest that this new syndrome can be named 'ADOC Wang's syndrome', summarizing the disorders of the four systems and indicative of th... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4922731 Tue, 31 May 2011 23:00:00 +0100 4922731 http://www.medworm.com/index.php?rid=4922730&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631180%26dopt%3DAbstract Conclusion. The average recovery of hearing and cessation of tinnitus was significantly better after treatment with Radix Astragali (RA) than after non-treatment with RA. RA can be valuable adjuvant therapy for patients with acute acoustic trauma (AAT). Objectives. AAT is one of the early indications for the use of RA. The reasons for administering RA to patients with AAT are based on experimental studies showing that noise exposure results in the formation of reactive oxygen species (ROS), which trigger metabolic damage to the organ of Corti. RA is a natural antioxidant. The aim of this study was to investigate the efficacy of RA in patients with AAT. Methods: We compared the recovery from hearing impairment and tinnitus in 40 ears treated with RA with 40 ears treated with non-RA. RA was ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4922730 Tue, 31 May 2011 23:00:00 +0100 4922730 http://www.medworm.com/index.php?rid=4922735&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21619495%26dopt%3DAbstract Authors: Reboll R, Martínez-Leon J, Zapater E, Juez M, Garcia-Planells J, Martinez-Cadenas C, Basterra J Abstract The aim of this study was to describe a previously unreported mutation in the SDHD gene, which has been linked to familial paraganglioma. Clinical data were collected from all members of the family, which had four siblings affected with paraganglioma. For the index patient, genomic DNA extraction from whole blood was performed using the High Pure PCR Template Preparation kit. The nucleotide sequence in the index patient revealed a deletion in the SDHD gene, c.165_169+14del. The loss of nucleotides in the DNA led to production of an anomalous protein. RNA analysis showed the absence of exon 2 in the sequence that corresponded to the mRNA from the index case. Genetic testing... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4922735 Sun, 29 May 2011 23:00:00 +0100 4922735 http://www.medworm.com/index.php?rid=4922737&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21619438%26dopt%3DAbstract Conclusion: The present study demonstrates that various response patterns of subjective visual vertical (SVV) can be identified during unilateral centrifugation (UC). It is proposed that these response types correspond to different degrees of compensation after disease. This is advantageous for monitoring the effect of rehabilitative measures and is useful in medico-legal issues. It also emerges that diagnosis of unilateral utricle function requires the determination not only of asymmetry ratio but also offset of SVV estimates. Objectives: A retrospective clinical study of SVV test results was performed to establish a classification and model of response types in patients with suspected otolith disorder. Methods: SVV measurements were made in 473 patients recruited from the dizziness clini... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4922737 Thu, 26 May 2011 23:00:00 +0100 4922737 http://www.medworm.com/index.php?rid=4922736&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21619439%26dopt%3DAbstract Conclusion. The suprameatal approach (SMA) for cochlear implantation is a safe procedure and is at least comparable to the classic mastoidectomy-posterior tympanotomy approach (MPTA) regarding the possibility of reducing electrode insertion trauma. Objectives. To compare the trajectory in the SMA with insertion through cochleostomy, to the MPTA with round window insertion. Methods: Nine temporal bones were implanted by both techniques, and the point of first contact of a precurved electrode was compared. Results: With the SMA, in all bones, the point of first contact was the inferior wall of the scala tympani and insertion was into the scala tympani. In the MPTA, in five of the bones, the point of first contact was the modiolus, the osseous spiral lamina or the basilar membrane. PMID: ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4922736 Thu, 26 May 2011 23:00:00 +0100 4922736 http://www.medworm.com/index.php?rid=4877048&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21612560%26dopt%3DAbstract Conclusions: Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL. Objectives. The present study investigated the prevalence of congenital CMV infection diagnosed retrospectively by detection of CMV DNA in dried umbilical cord specimens from children with unilateral or bilateral SNHL up to the age of 12 years. Methods: Preserved dried umbilical cords were collected from 134 children with bilateral (46 children) or unilateral (88 children) SNHL. DNA was extracted from the dried umbilical cords and CMV DNA was detected by quantitative PCR. G... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4877048 Wed, 25 May 2011 23:00:00 +0100 4877048 http://www.medworm.com/index.php?rid=4877049&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21612504%26dopt%3DAbstract Conclusion: We found no significant differences in the bacterial features of the maxillary sinuses between eosinophilic and neutrophilic chronic rhinosinusitis (CRS) with nasal polyps. Objectives: Since neutrophilic CRS is often influenced by a predisposition to bacterial infection, and eosinophilic CRS is likely to be developed by allergic antigens, differences in the microbiology between the two pathologies of CRS can be expected. The present study was designed to investigate the bacterial findings from the maxillary sinus in eosinophilic and neutrophilic CRS. Methods: Seventy patients with CRS with nasal polyps were divided into eosinophilic and neutrophilic types based on histopathological observations of the nasal polyps. The specimens for bacterial culture were obtained from the maxi... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4877049 Tue, 24 May 2011 23:00:00 +0100 4877049 http://www.medworm.com/index.php?rid=4877050&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21599549%26dopt%3DAbstract Conclusions: A set of Chinese Mandarin monosyllable test lists with good reliability and sensitivity was established. Objectives. The primary purpose of this study was to evaluate the equivalence of a group of monosyllable lists. Methods: A genetic algorithm was adopted to reorganize the material based on the Phoneme Allocation Table; 10 lists with 25 monosyllabic test items in each were generated. A two-factor design was used for the equivalence evaluation test. A total of 80 normal-hearing and native Mandarin-speaking university students (40 males and 40 females) participated in the trial. Every subject was tested with all 10 lists in sequence at 5 presentation levels (-5, 0, 5, 10, and 15 dB HL). Performance-intensity (P-I) function of each list was fit before P-I curve slope and recogn... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4877050 Sun, 22 May 2011 23:00:00 +0100 4877050 http://www.medworm.com/index.php?rid=4877052&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21595507%26dopt%3DAbstract Conclusion: Treatment of traumatic tympanic membrane (TM) perforation with everted or involute edge flaps at different time intervals within 1 week after the injury did not affect the perforation closure rate and mean closure time. Objective: To retrospectively analyze the effect of treatment at different time intervals for traumatic tympanic membrane perforation with gelatin sponge patch and edge approximation plus gelfoam patching. Methods: Patients with traumatic TM perforation visited at different days since the injury for medical treatment (1, 2, 3, 4, and 5-7 days post trauma). These patients were treated with the following prominent methods of treatment: gelatin sponge patch treatment and edge approximation plus gelfoam patching. Measurement indicators were perforation closure rate ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4877052 Wed, 18 May 2011 23:00:00 +0100 4877052 http://www.medworm.com/index.php?rid=4877051&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21595508%26dopt%3DAbstract Conclusions: Results from prior studies of quality of life (QoL) in heterogeneous patient groups (regarding disorder type and etiology) with olfactory disorders may be useful also for understanding QoL in homogeneous patient groups. Diagnosis and treatment of smell loss should be given high priority in polyposis with asthma, and coping strategies can be suggested to these patients. Objectives: To investigate the effects of smell loss on daily life and coping strategies in patients with smell loss without dysosmia and with nasal polyposis with asthma as the only primary etiology, and to compare these results with those from a prior study of a patient group with heterogeneous olfactory disorders and etiology. Methods: Fifty patients with smell loss and with nasal polyposis and asthma respond... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4877051 Wed, 18 May 2011 23:00:00 +0100 4877051 http://www.medworm.com/index.php?rid=4877053&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21574774%26dopt%3DAbstract Conclusion: We reported previously that hyperactivation of vasopressin type-2 receptor (V2R)-mediated signaling in the endolymphatic sac could affect endolymphatic fluid metabolism, resulting in the pathogenesis of endolymphatic hydrops. Taken together with the present endolymphatic sac tumor (ELST) study, it is suggested that disorder of V2R signaling in the endolymphatic sac for any reason could be involved in the pathogenesis of endolymphatic hydrops. Although it is due to tumor genesis in ELST, it is idiopathic in nature in Meniere's disease. Objective: We encountered two cases of ELST showing Meniere's disease-like symptoms. Both cases were suspected of having endolymphatic hydrops using neuro-otological examinations. To clarify the histopathological diagnosis of ELST and the molecula... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4877053 Sun, 15 May 2011 23:00:00 +0100 4877053 http://www.medworm.com/index.php?rid=4824147&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21563872%26dopt%3DAbstract Conclusion. A positional nystagmus pattern compatible with a condition of a light cupula in the lateral semicircular canal seen in clinical patients could be reproduced only partially in hemi-labyrinthectomized subjects during the stage of positional alcohol nystagmus 1 (PAN 1). Objectives. To mimic the condition of a light cupula in the lateral semicircular canal by using unilaterally deafferented subjects during the stage of PAN 1 and compare the results with those of patients with a light cupula. Methods: Five hemi-labyrinthectomized subjects were studied during PAN 1 with videonystagmography when they kept their heads straight forward or turned sideways in the prone and supine positions, respectively. A zero zone, indicating a cupula dysfunction, in which the geotropic nystagmus change... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824147 Wed, 11 May 2011 23:00:00 +0100 4824147 http://www.medworm.com/index.php?rid=4824146&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21563873%26dopt%3DAbstract Authors: Li JN, Han DY, Ji F, Chen AT, Wu N, Xi X, Shen WD, Yang SM Abstract A 28-year-old woman with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE syndrome) undergoing evaluation for multichannel cochlear implantation is described. The case history, diagnosis of mitochondrial disease, and assessment of the benefits of cochlear implantation are documented. The hearing level with cochlear implant and speech recognition were improved significantly for this patient. MNGIE syndrome is a rare congenital disorder of mitochondrial DNA (mt-DNA). It is crucial for the otolaryngologist to have awareness of MNGIE syndrome and other mitochondrial encephalomyopathies when patients present with sensorineural hearing loss (SNHL). Cochlear implantation can be recommended to patients wit... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824146 Wed, 11 May 2011 23:00:00 +0100 4824146 http://www.medworm.com/index.php?rid=4824145&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21563874%26dopt%3DAbstract Conclusion: This study showed that the ocular vestibular evoked myogenic potential (oVEMP) in response to air-conducted sound (ACS) reflects functions of different parts of the vestibular labyrinth from cervical VEMP (cVEMP). Objective: To determine whether the origin of the vestibular end organs of the oVEMP in response to ACS (500 Hz tone bursts) is the same as that of cVEMP. Methods: Twenty patients definitively diagnosed with unilateral Meniere's disease (MD), 6 patients with unilateral vestibular neuritis (VN), and 7 healthy subjects were enrolled. In these subjects, the oVEMP and cVEMP to air-conducted 500 Hz tone bursts (125 dBSPL) were measured. The patients also underwent caloric tests. Results: The MD patients did not show a significant association between their ACS oVEMP finding... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824145 Wed, 11 May 2011 23:00:00 +0100 4824145 http://www.medworm.com/index.php?rid=4824149&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21542672%26dopt%3DAbstract Conclusions: The results suggest that melanin inhibits formation of reactive oxygen species (ROS) and prevents apoptosis in spiral ganglion cells (SGCs) of pigmented guinea pigs following impulse noise. Objective: The stria vascularis of pigmented guinea pig cochlea contains melanocytes that produce melanin, which has a protective effect on noise-induced hair cell damage through its antioxidant property. ROS are involved in cochlear damage induced by impulse noise trauma. The purpose of the present study was to investigate the oxidative stress in SGCs of pigmented and albino guinea pigs after exposure to impulse noise. Methods: Pigmented and albino guinea pigs were exposed to impulse noise. Auditory thresholds were assessed by sound-evoked auditory brainstem response (ABR) before impulse n... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824149 Tue, 03 May 2011 23:00:00 +0100 4824149 http://www.medworm.com/index.php?rid=4824148&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21542673%26dopt%3DAbstract Conclusions: The incidence of oropharyngeal squamous cell cancer (OPSCC) in Finland has increased during the past decades. A similar change has been seen in the relative frequency of p16-positive head and neck squamous cell carcinoma (HNSCC). As p16 is a surrogate marker for human papilloma virus (HPV) infection, and as most p16-positive HNSCCs are OPSCC, HPV infection may have had a role in the observed increased incidence of OPSCC. Objectives: Numerous studies have shown that HPV is an independent risk factor for OPSCC. We aimed to use p16 as a surrogate marker of HPV infection to study its role as a possible risk factor in OPSCC. Furthermore, the change in the incidence of OPSCC in Finland was studied. Methods: HPV status was determined by p16 immunohistochemistry of 135 HNSCC tumour sp... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824148 Tue, 03 May 2011 23:00:00 +0100 4824148 http://www.medworm.com/index.php?rid=4824153&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21534714%26dopt%3DAbstract Conclusion: Rehabilitation was significantly efficient in both groups of patients with synkinesis, especially in those in whom treatment with botulinum toxin type A (BTX-A) preceded physical rehabilitation. Objective: To determine the influence of preventive treatment with BTX-A on synkinesis when physical rehabilitation is planned. Methods: Twenty patients, who recovered from facial palsy with final House-Brackmann (HB) grade II and III, were randomized to assess the efficacy of preventive BTX-A treatment on final synkinesis score after physical rehabilitation. Synkinesis was graded according to the four-point scale derived from the SunnyBrook Facial Grading System (FGS). Physical rehabilitation was carried out using NeuroMuscular Retraining Therapy (NMRT). In the randomized groups, NMRT ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824153 Sun, 01 May 2011 23:00:00 +0100 4824153 http://www.medworm.com/index.php?rid=4824152&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21534715%26dopt%3DAbstract Conclusion. A homogeneity selection could establish a homogenous resource for Chinese Mandarin monosyllabic test lists. Objective: This study aimed to develop a set of succinct and phonemically balanced monosyllabic Mandarin recognition test lists with good item homogeneity, in an effort to meet the need for Chinese Mandarin speech recognition test materials. Methods: In reference to the Chinese phonemes distribution probability, we developed the Phoneme Allocation Table, which decided the occurrence of all consonants, vowels, and semantic tones in each list. A total of 489 monosyllables were selected and organized into 30 lists, with 25 monosyllables in each. A two-factor design was used to screen homogenous items out. Sixty normal-hearing native Mandarin speakers participated in experime... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824152 Sun, 01 May 2011 23:00:00 +0100 4824152 http://www.medworm.com/index.php?rid=4824151&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21534716%26dopt%3DAbstract Conclusion: We suggest that cochlear implantation (CI) should be a good therapeutic modality for hearing restoration in patients with common cavity malformed ears. Objective: To analyze hearing improvement from CI performed in common cavity malformed cochleae. Methods: A total of 11 patients (5 male and 6 female, mean age 4.5 ± 2.8 years) and 12 ears were enrolled in this study. During the insertion of electrodes, we used C-arm fluoroscopy to avoid intrameatal placement. We evaluated hearing improvement every 6 months and the mean follow-up period was 80.5 ± 24.1 months (53-125 months). Results: During the operation, there were only four cases with fully inserted electrodes. Cerebrospinal fluid gushed out in two cases during the cochleostomy and postoperative meningitis occurred in two p... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824151 Sun, 01 May 2011 23:00:00 +0100 4824151 http://www.medworm.com/index.php?rid=4824150&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21534717%26dopt%3DAbstract Conclusion: The results of the present study indicate the potential of CCL20 as an effective mucosal adjuvant and suggest that nasal vaccination with P6 in combination with nasal CCL20 might be an effective regimen for the induction of nontypable Haemophilus influenzae (NTHi)-specific protective immunity. Objectives: Nasal vaccination is an effective therapeutic regimen for preventing upper respiratory infections. In the development of nasal vaccine, an appropriate adjuvant is required. In the present study we examined the efficacy of CCL20 as a mucosal adjuvant. Methods: CCL20 was administered intranasally to mice, which were then immunized intranasally with P6 protein of NTHi, and P6-specific immune responses were examined. In addition, NTHi challenges were performed and the level of NTH... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824150 Sun, 01 May 2011 23:00:00 +0100 4824150 http://www.medworm.com/index.php?rid=4824170&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21492065%26dopt%3DAbstract Conclusion: Down-regulating human telomerase reverse transcriptase (hTERT) expression will significantly suppress the cell viability of laryngeal squamous cell carcinoma Hep-2, which was mainly due to the inhibition of cyclin D1 and thus G1/S phase transition. Objective: Small-interfering RNA (siRNA) targeting hTERT can arrest the cell cycle of cancer cells, as well as inhibit telomerase activity and cell viability. However, the precise mechanisms still remain unclear. Here, we investigate the regulatory role of hTERT in cyclin D1 in laryngeal squamous carcinoma. Methods: Short hairpin RNAs (shRNAs) specifically targeting hTERT were constructed and expressed in Hep-2 cells. Cell proliferation was measured by CCK-8 assay. Expression of hTERT, cyclin D1, cyclin E, c-myc, and GAPDH was detect... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824170 Sat, 30 Apr 2011 23:00:00 +0100 4824170 http://www.medworm.com/index.php?rid=4824169&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21492066%26dopt%3DAbstract Conclusions: No positive effects of early preventive rehabilitation could be identified. The results do not contradict the proposition that rehabilitation based on self-care can be effective but it is important to establish evidence-based training programs and identify proper instruments for selection of patients and evaluation of intervention. Objectives: Patients with head and neck cancer suffer from functional impairments due to intense treatment. In this study, we investigated the effectiveness of an experimental early preventive rehabilitation using hard, objective end points in a nonselective, longitudinal, prospective cohort study. Methods: In all, 190 patients were included in the program and received instructions for training before the start of treatment with the aim of reducing ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824169 Sat, 30 Apr 2011 23:00:00 +0100 4824169 http://www.medworm.com/index.php?rid=4824156&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21526905%26dopt%3DAbstract Conclusion. The inner ear monitoring system is useful for identifying the affected branches of the vestibular nerve in cases of vestibular neuritis, providing insight about the interval for the relief of vertigo. Objective: This study conducted an inner ear monitoring system including audiometry, and caloric, ocular vestibular evoked myogenic potential (oVEMP), and cervical VEMP (cVEMP) tests in cases of vestibular neuritis for assessing the affected branches of the vestibular nerve. Methods: Twenty patients with vestibular neuritis underwent caloric, oVEMP, and cVEMP tests. Type I indicates that one of the three tests is abnormal; type II indicates that two test results are abnormal; and type III indicates that no test result is normal. Results: All patients had normal hearing, bilaterall... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824156 Wed, 27 Apr 2011 23:00:00 +0100 4824156 http://www.medworm.com/index.php?rid=4824155&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21526906%26dopt%3DAbstract Conclusion. Our herpes simplex virus (HSV) labyrinthitis mouse model suggests that HSV infection induces vestibular neuritis and sudden deafness. Objective: Viral labyrinthitis has been postulated to play a role in vestibular neuritis and sudden deafness. We established a mouse model to investigate the pathogenesis of HSV-induced labyrinthitis. The relationship between HSV infection and apoptosis in the labyrinth was assessed. Methods: HSV types 1 and 2 were inoculated into the middle ear of mice, and the function of the cochlear and vestibular nerves was assessed. Histopathological changes were examined with hematoxylin and eosin staining. Anti-HSV immunohistochemistry staining and TUNEL staining were done to investigate the relationship between HSV-infected cells and apoptotic cells. Res... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824155 Wed, 27 Apr 2011 23:00:00 +0100 4824155 http://www.medworm.com/index.php?rid=4824154&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21526907%26dopt%3DAbstract Conclusion. These results suggest that the beneficial effect of astragaloside IV on impulse noise-induced hearing loss may be due to its ability to inhibit inducible nitric oxide synthase (iNOS) and prevent the formation of reactive nitrogen species (RNS). Objective: Astragaloside IV is the major active constituent of Astragalus membranaceus, which has been widely used for the treatment of diseases in China due to its antioxidant properties. iNOS and RNS are involved in damage induced by impulse noise trauma. The purpose of the present study was to investigate if astragaloside IV has the potential to reduce cochlear damage from impulse noise. Methods: Guinea pigs in the experimental group were administered astragaloside IV intragastrically. Auditory thresholds were assessed by sound-evoked... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824154 Wed, 27 Apr 2011 23:00:00 +0100 4824154 http://www.medworm.com/index.php?rid=4824160&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21521008%26dopt%3DAbstract Conclusions: Coblation was seen to be a much safer method for tonsil reduction surgery with less morbidity and with a higher efficacy in early and long-term follow-up. Objective: The objective was to compare the efficacy, morbidity and safety of three techniques for reduction of tonsil size in tonsillar hypertrophy in children. Methods: This was a prospective, randomized clinical study. Seventy-nine children aged 4-13 years with symptoms of tonsillar hypertrophy were included in the study. They were randomized to the coblator (group A), laser tonsillotomy (group B) or radiofrequency (group C) technique for tonsil reduction. The efficacy was evaluated by assessing tonsillar size after surgery. Morbidity was evauated by assessing by postoperative pain and return to normal diet and activity. ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824160 Mon, 25 Apr 2011 23:00:00 +0100 4824160 http://www.medworm.com/index.php?rid=4824159&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21521009%26dopt%3DAbstract Conclusions: Radial forearm free flap (RFFF)-accompanied phonation tube (PT) for voice and speech restoration after pharyngolaryngectomy is promising, especially in phonation efficacy and intelligibility. It offers not only another safe surgical option but also a satisfactory result for such patients with advanced hypopharyngeal cancer. Objectives: We use RFFF with RFFF-accompanied PT for one-stage reconstruction both for tissue defect and voice reconstruction in patients undergoing total pharyngolaryngectomy. Methods: Eight male patients with advanced hypopharyngeal cancer underwent total pharyngolaryngectomy. Voice restoration was done with RFFF-accompanied PT. Phonation outcomes and speech outcomes of the patients were evaluated and scored. Results: The mean follow-up time was 13.7 mont... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824159 Mon, 25 Apr 2011 23:00:00 +0100 4824159 http://www.medworm.com/index.php?rid=4824158&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21521010%26dopt%3DAbstract Authors: Hou ZQ, Han DY Abstract Sigmoid sinus diverticulum-induced pulsatile tinnitus is a rare medical problem. Here we report a case where pulsatile tinnitus occurred in the perimenopause with evidence of sigmoid sinus diverticulum. The tinnitus disappeared with the restoration of hearing after surgery. While diagnosis is critical for the treatment, this disorder can be diagnosed relatively easily, and a satisfactory therapeutic outcome can be achieved using a simple surgical approach. The sigmoid sinus diverticulum may be a clinical manifestation of osteoporosis occurring in the perimenopausal period. PMID: 21521010 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824158 Mon, 25 Apr 2011 23:00:00 +0100 4824158 http://www.medworm.com/index.php?rid=4824157&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21521011%26dopt%3DAbstract Conclusion. The results suggest that the procedure is effective in the repair of nasal septal perforations (10-20 mm in diameter). Therefore, we consider it to be a good alternative for repairing nasal septal perforations. Objective: To introduce and evaluate a technique of pedicled local mucosal flap with the interposition of an autogenous graft in the repair of nasal septal perforations. Methods: Between 2004 and 2008, the clinical notes of 28 patients with nasal septal perforations (10-20 mm in diameter) undergoing the surgery of pedicled local mucosal flap with the interposition of an autogenous graft were reviewed. Results: Complete perforation closure was achieved in 26 cases (92.9%). Two patients had a reperforation, one receiving a second technique and a subsequent successful closu... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824157 Mon, 25 Apr 2011 23:00:00 +0100 4824157 http://www.medworm.com/index.php?rid=4824164&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21504270%26dopt%3DAbstract Conclusions: Analysis of the complete mtDNA genome and X-linkage of this five-generation Chinese family revealed that the 1555A > G mutation may lead to deafness. Objectives: Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. However, the variable clinical phenotype and incomplete penetrance of mtDNA 1555A > G-induced hearing loss complicate our understanding of this mutation. We aimed to identify whether nuclear genes, mitochondrial haplotypes/variants, and a possible threshold effect are involved in its manifestation in the pedigree. Methods: We performed clinical, genetic, and X-linkage analysis of a five-generation Chinese family in which all the affected individuals were male. Results: Clinical evaluation revealed that affect... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824164 Mon, 18 Apr 2011 23:00:00 +0100 4824164 http://www.medworm.com/index.php?rid=4824163&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21504271%26dopt%3DAbstract Conclusion: Fas ligand (FasL) gene therapy may provide a new efficient therapeutic model for head and neck squamous cell cancer (HNSCC). Acid ceramidase (AC) may not play an important role in the sensitivity of HNSCC cell lines to Fas-induced apoptosis. Objectives: The aims of this study were to investigate the efficacy of FasL gene therapy for HNSCC in vitro and to determine whether the expression of AC in different kinds of HNSCC cell lines is related to the sensitivity of HNSCC cell lines to Fas-mediated apoptotic induction. Methods: Three HNSCC cell lines (Hep-2, MMSI, and SCCVII) were transfected with pEGFP-FasL, a plasmid containing a modified human FasL gene fused to enhanced green fluorescent protein (GFP). pEGFP-C1, a plasmid containing the GFP gene alone, was used as a control. C... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824163 Mon, 18 Apr 2011 23:00:00 +0100 4824163 http://www.medworm.com/index.php?rid=4824162&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21504272%26dopt%3DAbstract We report here the case of a 67-year-old woman who presented with right-sided mixed hearing loss, a right external auditory canal mass, ear fullness, otalgia, blood-stained otorrhea, and pain around the TMJ, associated with difficulty in opening the mouth. CT and MRI revealed a mass involving the TMJ, infratemporal fossa, and pterygopalatine fossa. The patient underwent tumor resection via an infratemporal fossa approach type B. Gross total tumor removal was achieved, with no facial nerve paralysis or other complications observed after surgery. No recurrence or residual tumors were observed on CT and MRI, even after 7.5 years of follow-up. We conclude that temporal bone chondroblastomas are extremely rare and aggressive, but the outcome after appropriate surgical treatment is favorable. Fr... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824162 Mon, 18 Apr 2011 23:00:00 +0100 4824162 http://www.medworm.com/index.php?rid=4824161&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21504273%26dopt%3DAbstract Conclusion: Bipolar scissors tonsillectomy followed by cooling down the pharyngeal mucosa has advantages in terms of postoperative pain and intraoperative blood loss compared with cold dissection. Objectives: The purpose of this study was to compare the postoperative pain between bipolar scissors tonsillectomy followed by cooling the pharyngeal mucosa and a traditional cold dissection. Methods: A total of 189 patients aged more than 16 years were operated due to habitual tonsillitis, obstructive sleep apnea syndrome, and IgA nephropathy. Of these, 79 patients were operated using bipolar scissors followed by cooling the pharyngeal mucosa with 4°C saline for 10 min just after the removal of tonsils. The other 110 patients underwent cold dissection tonsillectomy. Outcome measures were intrao... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824161 Mon, 18 Apr 2011 23:00:00 +0100 4824161 http://www.medworm.com/index.php?rid=4824168&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21492068%26dopt%3DAbstract Conclusion: This study shows that by using the round window approach and deep insertion, it is possible to reduce electrode insertion trauma (EIT), as indicated by the results of the hearing preservation marker. Objectives: In this prospective study EIT was evaluated in 42 subjects with low frequency hearing before surgery with 28 mm round window deep insertion. Methods: The degree of hearing preservation was a marker of EIT. Pure tone audiometry, monosyllable testing was conducted preoperatively and then at 3, 6, and 13 months after surgery. Results: Immediate hearing preservation (3 months postoperatively) was 92.9% (39/42). The surgery-related hearing preservation 13 months after surgery varied from 85% (34/40) to 90% (36/40). The ipsilateral implanted ear showed significant differences... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824168 Thu, 14 Apr 2011 23:00:00 +0100 4824168 http://www.medworm.com/index.php?rid=4824167&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21492069%26dopt%3DAbstract We report a 43-year-old female with 12-month history of recurrent attacks of isolated vertigo who presented with acute pontine infarctions. Clinical examination and vestibular function testing showed bilateral vestibular hypofunction affecting the horizontal and posterior semicircular canals and right saccule. Diffusion-weighted magnetic resonance imaging (MRI) demonstrated acute bilateral pontine infarcts and significant vertebrobasilar stenoses. The findings of recurrent isolated vertigo and bilateral vestibular hypofunction should not prevent a search for vertebrobasilar ischaemia, particularly in the presence of vascular risk factors. PMID: 21492069 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824167 Thu, 14 Apr 2011 23:00:00 +0100 4824167 http://www.medworm.com/index.php?rid=4824166&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21492070%26dopt%3DAbstract Conclusions: In survival analysis, the combined Charlson comorbidity index (CCI) can be considered as a prognostic factor independent of the tumor node metastasis (TNM) classification, tumor stage, and tumor location. Severe comorbidity was the factor that had the greatest impact on prognosis in cases of initial tumor. Objective: To study the influence of comorbidity on the survival of patients undergoing surgery for larynx cancer. Methods: This was a retrospective study of the survival of 231 patients with laryngeal cancer who underwent surgery between 1995 and 2002. The CCI was used to assess comorbidity, the Kaplan-Meier method was used for survival analysis, and the Cox proportional risk regression model was used to identify independent prognostic factors. Results: The multivariate ana... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824166 Thu, 14 Apr 2011 23:00:00 +0100 4824166 http://www.medworm.com/index.php?rid=4824165&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21492071%26dopt%3DAbstract Conclusion: The papers collected in our study demonstrated that there were no significant differences in the effectiveness of sound transmission and stability of the prosthesis between the titanium and non-titanium group. However, further randomized controlled trials with large sample sizes are needed to improve the estimation. Objective: To compare the effectiveness of sound transmission and stability of the prostheses in the titanium or non-titanium ossiculoplasty groups by meta-analysis for clinical implications and applications. Methods: Previous studies comparing the hearing status of patients with titanium and non-titanium prostheses were reviewed on PubMed, accompanied by a manual search of all the related references. The eligibility of the investigation was independently confirmed ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824165 Thu, 14 Apr 2011 23:00:00 +0100 4824165 http://www.medworm.com/index.php?rid=4824173&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480759%26dopt%3DAbstract Conclusion: The findings from this study extend the use of the local application of D-methionine (D-met) to protect against acoustic trauma and demonstrate that D-met slowly diffuses from the perilymph. Objectives: The objectives of the study were to determine the effect of D-met on auditory function and morphology after acoustic trauma and to measure the concentration of D-met in perilymph. Methods: Auditory thresholds were determine before, immediately after, and 24 h after acoustic trauma. Cochleae were analyzed using immunocytochemistry for c-Fos, TUJI, and cytochrome c. The concentration of D-met was determined from perilymph. Results: Protection against acoustic trauma (immediately and 24 h post trauma) on auditory brainstem thresholds was found at a time when the concentration of D-... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824173 Sun, 10 Apr 2011 23:00:00 +0100 4824173 http://www.medworm.com/index.php?rid=4824172&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480760%26dopt%3DAbstract Conclusion: Although pretherapeutic radiological examination is a very useful technique for the evaluation of tumor invasion into specific laryngeal subsites, the pretherapeutic radiologic staging can be challenging when distinguishing tumor from peritumoral inflammation. PMID: 21480760 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824172 Sun, 10 Apr 2011 23:00:00 +0100 4824172 http://www.medworm.com/index.php?rid=4824171&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21480761%26dopt%3DAbstract Conclusions: Altered expression of claudin-1, claudin-7, and tricellulin in early tonsillar squamous cell carcinoma (SCC) independent of human papilloma virus (HPV) infection may lead to tumor progression. Objectives: Integral tight junction proteins, the claudins and tricellulin, play a crucial role in all tissues. HPV is significantly associated with tonsillar SCC. We sought to determine the expression of claudin-1, claudin-7, and tricellulin in HPV-infected and HPV-free tonsillar SCC. Methods: Twenty-eight tonsillar SCCs were studied by immunohistochemical analysis and real-time reverse transcription polymerase chain reaction with in situ hybridization analysis. Results: Compared with normal tissues, claudin-1 was strongly expressed, whereas claudin-7 and tricellulin were weakly express... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824171 Sun, 10 Apr 2011 23:00:00 +0100 4824171 http://www.medworm.com/index.php?rid=4824174&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476785%26dopt%3DAbstract Conclusion: The survival rates and prognostic factors for nasopharyngeal cancer (NPC) were found to be similar to the published series from endemic regions. Objectives: The purpose of this retrospective study was to evaluate treatment outcome and prognostic factors of NPC patients treated with radiotherapy or chemoradiotherapy in a non-endemic region. Methods: We analyzed clinical characteristics, treatment outcome, and prognostic factors of NPC patients in a non-endemic region, and compared our institution's results with the published literature including a similar patient population from endemic and non-endemic regions. Among 248 NPC patients, 71 (28.6%) were female and 177 (71.4%) were male with a median age of 48 years. Results: Within a median 59 months (range 22-178) of follow-up, lo... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824174 Thu, 07 Apr 2011 23:00:00 +0100 4824174 http://www.medworm.com/index.php?rid=4824175&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21469911%26dopt%3DAbstract Conclusion: Vertigo attacks in patients with benign recurrent vertigo (BRV) cannot be distinguished from those in patients with Meniere's disease on the basis of duration, triggers or associated symptoms (other than auditory). A subset of BRV is associated with migraine. Objective: To investigate whether clinical features of vertigo attacks can distinguish patients with BRV from those with Meniere's disease and whether subtypes of BRV can be identified. Methods: A structured interview was used to analyze features in patients with BRV, i.e. those who have normal audiograms and caloric test results even though they have had recurrent vertigo (n = 63). A group of patients with definite Meniere's disease (n = 112) served as the comparison group. Results: Compared with the Meniere's disease gro... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824175 Tue, 05 Apr 2011 23:00:00 +0100 4824175 http://www.medworm.com/index.php?rid=4824179&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21466260%26dopt%3DAbstract Conclusion: The visual outcomes of endoscopic treatment of optic neuropathy are favorable. However, no specific prognostic factor was associated with good outcome. Objective: To investigate visual outcomes of patients with optic neuropathy caused by paranasal mucocele or sinusitis. Methods: The clinical course in 38 patients with rhinogenic optic neuropathy was investigated retrospectively. All patients underwent endoscopic sinus surgery and ophthalmologists measured preoperative and postoperative visual acuities. Results: Visual acuity completely recovered in 31 patients and partially in 2 patients, and did not recover in 5 patients. Age, sex, sinus involved (ethmoid or sphenoid), preoperative visual acuity, abnormal fundus findings, duration of symptoms, steroid use, and coexistence of d... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824179 Mon, 04 Apr 2011 23:00:00 +0100 4824179 http://www.medworm.com/index.php?rid=4824178&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21466261%26dopt%3DAbstract Conclusion: The results of this study show that the temporal processing ability in children with auditory neuropathy (AN) can be restored to some degree by electrical stimulation through a cochlear implant. In addition, the electrically evoked compound action potential (ECAP) may be a useful index to predict outcomes in implanted children with AN. Objectives: The purpose of this study was to evaluate restoration of the temporal processing abilities in implanted children with AN using ECAP recovery function and speech perception. Methods: Ten children who had received cochlear implantations participated in this study, including six with AN and four with sensorineural hearing loss (SNHL). ECAP recovery functions were measured, and the slopes of ECAP recovery functions in implanted children w... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824178 Mon, 04 Apr 2011 23:00:00 +0100 4824178 http://www.medworm.com/index.php?rid=4824177&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21466262%26dopt%3DAbstract Conclusion: This universal newborn hearing-screening (UNHS) programme revealed high efficacy. The proportion of congenital sensorineural hearing loss was higher in left ears and in males than in right ears and females, which was in line with the systematic ear asymmetries and sex differences in transient-evoked otoacoustic emission (TEOAE) pass percentage. Objectives: To study the long-term outcome of a UNHS programme based on multiple TEOAEs and clinical click-evoked auditory brainstem response (ABR). Method: The study included all the newborns that were screened during a 6-year period (n = 31 092). TEOAE pass/fail was analysed in detail. In an assessment performed 10 years after the start of the 6-year UNHS, prevalence, degree and type of congenital hearing loss were studied. Results: Th... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824177 Mon, 04 Apr 2011 23:00:00 +0100 4824177 http://www.medworm.com/index.php?rid=4824176&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21466263%26dopt%3DAbstract Conclusion: Matrix metalloproteinase (MMP)-20 is overexpressed in laryngeal squamous cell carcinoma (LSCC) compared with the adjacent normal laryngeal epithelium and MMP-20 plays a role in lymph node metastasis. Overexpression of MMP-20 may be used as a significant prognostic factor for lymph node metastasis. All the findings indicate that MMP-20 may play a role in the initiation and progression of LSCC. Objective: The MMPs are a gene family of zinc-dependent endopeptidases that have been implicated in tumor invasion and metastasis, and MMP-20 is a new member of the MMP family. The purpose of this study was to investigate whether MMP-20 is overexpressed in human LSCC and, if so, the significance of its overexpression in relation to clinical parameters. Methods: We analyzed 33 cases of LSCC... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4824176 Mon, 04 Apr 2011 23:00:00 +0100 4824176 http://www.medworm.com/index.php?rid=4606590&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21401447%26dopt%3DAbstract Authors: Grénman R, Hörmann K, Olofsson J Since 1990 Europe has undergone highly significant political and economic changes: the end of the division of East and West, the disintegration of the Soviet Union into independent countries and the enlargement of the European Union (EU). This has also changed the scenario from the perspective of the medical profession to a high degree. PMID: 21401447 [PubMed - in process] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4606590 Fri, 18 Mar 2011 15:15:17 +0100 4606590 http://www.medworm.com/index.php?rid=4606589&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21401448%26dopt%3DAbstract Conclusion: Co-option of the enzyme secretory phospholipase A2 (sPLA2) and adoption of tertiary conformation are essential factors in the multifunctionality of otoconin 90 (OC90) and homologous modulators. Objective: To present results of in vitro studies of recombinant otoconial proteins for the understanding of current concepts of biomolecular mechanisms controlling otoconial mineralization. Methods: In vitro characterization of recombinant otoconial proteins with respect to crystal growth parameters and solution state behavior. Evaluation by HR-SEM, micro-Raman, circular dichroism, in combination with molecular modeling of individual domains and whole OC90. Results: Polymorph selection: recombinant otoconin 22 (rOC22) in vitro selects calcite rather than aragonite, expression of which r... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4606589 Fri, 18 Mar 2011 15:15:13 +0100 4606589 http://www.medworm.com/index.php?rid=4606588&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21401449%26dopt%3DAbstract Conclusion: There is no significant difference in speech recognition scores obtained with the Vibrant Soundbridge and the open-fit hearing aid. However, the Vibrant Soundbridge may be superior to open-fit hearing aids in improving hearing at high frequencies (4-8 kHz). Objectives: To assess whether an improvement in speech recognition conferred by Vibrant Soundbridge is more marked than that afforded by open-fit hearing aids in patients with sloping high frequency sensorineural hearing loss (SNHL). Methods: This study had a self-control prospective design. Seven patients aged 21-62 years with sloping high frequency SNHL were recruited into the study. Each patient received a Vibrant Soundbridge middle ear implant (Vibrant MED-EL) and wore an open-fit hearing aid (Danavox, DOT 10). Speech re... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4606588 Fri, 18 Mar 2011 15:15:09 +0100 4606588 http://www.medworm.com/index.php?rid=4606592&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21395473%26dopt%3DAbstract Conclusion: These preliminary data show a decrease in nasal tactile sensitivity and point out interesting aspects of the nasal chronic inflammatory condition in allergic rhinitis. Objectives: The aim of this study was to evaluate the effects of allergic rhinitis on nasal tactile sensitivity during the intercritical period. Methods: A total of 70 patients aged between 18 and 67 years (average 42 years), with a positive history of allergy caused by seasonal outdoor allergens, were included (group A). Patient outcome was assessed by the nasal monofilament test: a set of 20 Semmes-Weinstein monofilaments was used to detect nasal sensitivity for both nasal cavities. The sensitivity threshold was recorded as the minimum monofilament size with which patients could detect at least two of three sti... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4606592 Mon, 14 Mar 2011 00:00:00 +0100 4606592 http://www.medworm.com/index.php?rid=4606591&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21395474%26dopt%3DAbstract Conclusions: We suggest that contralateral level IV dissection is not necessary in patients with cN0 hypopharyngeal squamous cell carcinoma (HPSCC). Objectives: Elective treatment of neck nodes is very important in the management of cN0 HPSCC. A selective neck dissection neck level II to IV (SND II-IV) is widely accepted as an elective neck treatment of cN0 HPSCC. However, there has been a lot of effort to reduce the extent of surgery. Therefore, we investigated the incidence of level IV metastasis and regional recurrence in cN0 HPSCC. Methods: We performed a retrospective review of 40 patients who underwent SND II-IV as an elective treatment for cN0 HPSCC from 1992 to 2010. Results: In all, 30 bilateral and 10 unilateral SND II-IVs were performed in 40 patients. Of the 70 SND II-IV specim... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4606591 Mon, 14 Mar 2011 00:00:00 +0100 4606591 http://www.medworm.com/index.php?rid=4606593&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21391775%26dopt%3DAbstract Conclusion: The results indicate that electrogustometry and the filter paper disc method are reliable methods to measure taste with a high degree of reproducibility. Objectives: To thoroughly evaluate the reliability of electrogustometry and the filter paper disc method for taste assessments. Methods: Thirty-nine healthy test persons without any history of chronic middle ear disease, aged between 27 and 62 years, were recruited. In all, 772 electrogustometry and 30 filter paper disc assessments were made. A nerve decay test was performed, with measures taken before and after eating sweet, sour, bitter, salt, a mild or spicy meal, after smoking, and after taking Swedish tobacco snuff ('snus'), as well as before and after local anesthesia of the tongue. Measurements were performed on 5 conse... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4606593 Thu, 10 Mar 2011 00:00:00 +0100 4606593 http://www.medworm.com/index.php?rid=4606597&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21366505%26dopt%3DAbstract Conclusion: A better animal model of autoimmune inner ear disease (AIED) in Sprague-Dawley rats has been developed by combination with high dose of pertussis toxin. This study also indicated that inner ear-specific antigens can be involved in autoimmune reactions. Cell-mediated immune injury can play an important role in the induction of AIED, at least in the earlier stage. Objectives: The purpose of this study was to develop a more suitable rat model that demonstrated closer resemblance to the pathophysiological process in AIED. Methods: Ninety-six female Sprague-Dawley rats were divided into four groups. They were subcutaneously immunized with crude inner ear antigen/complete Freund's adjuvant (CIEAg/CFA), or intraperitoneal injection of 500 ng pertussis toxin (PT), or injection of CIEAg... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4606597 Thu, 03 Mar 2011 00:00:00 +0100 4606597 http://www.medworm.com/index.php?rid=4606596&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21366506%26dopt%3DAbstract Conclusion: The saccular duct and endolymphatic sinus run in the bony groove, before reaching the orifice of the vestibular aqueduct. We first clinically visualized this sulciform groove using three-dimensional (3D) cone beam CT images. This strategy can be useful to assess the condition of the saccular duct and endolymphatic sinus concerning the longitudinal flow system of endolymph. Objective: To assess the saccular duct and endolymphatic sinus in the endolymphatic system in order to advance clinical studies on inner ear dysfunction. Methods: The sulciform groove of the saccular duct and endolymphatic sinus of human subjects was analyzed by cone beam CT and compared with that of a cadaver. Results: We could obtain reconstructed 3D CT images of the sulciform groove of the saccular duct an... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4606596 Thu, 03 Mar 2011 00:00:00 +0100 4606596 http://www.medworm.com/index.php?rid=4490055&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21319945%26dopt%3DAbstract Conclusion: Blockage of the endolymphatic duct is a significant finding in Meniere's disease. The position of the utriculo-endolymphatic valve (UEV) and blockage of the ductus reuniens in the temporal bones were not found to be directly indicative of Meniere's disease. Objective: Comparison of blockage of the longitudinal flow of endolymph between ears affected by Meniere's disease and normal ears. Methods: We examined 21 temporal bones from 13 subjects who had Meniere's disease and 21 normal temporal bones from 12 controls. Results: The endolymphatic duct was blocked in five (23%) ears affected by Meniere's disease (p = 0.016). The utricular duct was blocked in 16 (76%) ears affected by Meniere's disease and 11 (52%) normal ears (p = 0.112). The saccular duct was blocked in 6 (28%) of ear... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4490055 Fri, 18 Feb 2011 08:00:18 +0100 4490055 http://www.medworm.com/index.php?rid=4490054&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21319946%26dopt%3DAbstract Conclusions: The validated finite element model of human middle ear can be used as a tool in hearing loss research. Objective: To establish an accurate finite element model of the external ear canal and middle ear through micro-computer tomography and test its feasibility in the human. Methods: A fresh specimen of human temporal bone was scanned by micro-computer tomography. The finite element model was established based on the images, and then the simulation results were compared with published experimental data. Results: After a series of simulations were conducted, the simulated results were compatible with the published experimental data and this confirms the validation of the finite element model. PMID: 21319946 [PubMed - in process] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4490054 Fri, 18 Feb 2011 08:00:15 +0100 4490054 http://www.medworm.com/index.php?rid=4490053&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21319947%26dopt%3DAbstract Conclusion: The Meniett device is a minimally invasive and safe treatment that may be used to provide longer-term reduction of vestibular symptoms in patients with delayed endolymphatic hydrops (DEH) as well as those with Meniere's disease (MD). Objective: The effects of the Meniett device were evaluated in patients with a diagnosis of definite MD or DEH according to the 1995 AAO-HNS criteria. Methods: Twenty-nine ears of 28 patients with MD and 5 ears of 5 patients with DEH (ipsilateral type 4, contralateral type 1) were treated with the Meniett device by the Middle Ear Pressure Treatment Research Group of Japan. All of the patients had failed to respond to medical treatment including diuretics before the pressure treatment. Results: Sixteen (57%) patients with MD and all five (100%) pati... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4490053 Fri, 18 Feb 2011 08:00:11 +0100 4490053 http://www.medworm.com/index.php?rid=4490052&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21322766%26dopt%3DAbstract We report on a rare case of cochlear implantation in a patient affected by relapsing polychondritis (RP), which over time induced cochlear fibrosis/ossification and deterioration of previously excellent hearing performance. The clinical course was determined by CT scan, electrophysiology, and speech perception data. We conclude that RP is a severe autoimmune connective disorder that can cause profound sensorineural hearing loss. Cochlear implantation in these patients can provide excellent performance. Continuation of therapy may improve prognosis, but relapses involving inner ear structures can determine fibrosis/ossification of the modiolus and interfere with cochlear implant use. PMID: 21322766 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4490052 Tue, 15 Feb 2011 00:00:00 +0100 4490052 http://www.medworm.com/index.php?rid=4490056&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21319943%26dopt%3DAbstract Conclusions: Vestibular myogenic potential responses were present when evoked by tone burst stimuli of 250, 500, 1000, and 2000 Hz; however, they were more effective for low-frequency stimuli. Objectives: Few studies refer to specific frequency sensitivities of the saccular afferents. Accordingly, the aim of the present study was to analyze p13 and n23 latency and amplitude parameters of vestibular evoked myogenic potential (VEMP) captured with tone bursts at frequencies of 250, 500, 1000, and 2000 Hz. Methods: VEMP was captured in 156 ears (78 subjects), recorded in the sternocleidomastoid muscle, averaging 200 stimuli, stimulus rate of 5 Hz, duration 10 ms (rise, 4 ms; plateau, 2 ms; fall, 4 ms), at intensity of 95 dB nHL. The recordings were performed in 50 ms windows. Results: We found... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4490056 Mon, 14 Feb 2011 00:00:00 +0100 4490056 http://www.medworm.com/index.php?rid=4490058&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21314243%26dopt%3DAbstract Conclusions: Our observations support the concept of bilateral cortical activation with monaural and binaural auditory stimulation. The observation that most of the significantly activated areas were the same with monaural or binaural stimulation suggests that the differences in auditory perception with binaural stimulation are not due to the involvement of significantly different processing centers but, more likely, to the type of information that reaches these centers for processing. The observation that the degree of stimulation was less intense in binaural than in monaural stimulation supports the concept that a richer binaural auditory stimulation compared with monaural stimulation does not mean summation of stimuli but integration and better processing of the information. For normal ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4490058 Fri, 11 Feb 2011 00:00:00 +0100 4490058 http://www.medworm.com/index.php?rid=4490057&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21314244%26dopt%3DAbstract Conclusions: This report details our experience in the management of 56 consecutive patients with mastoid encephaloceles and cerebrospinal fluid (CSF) leaks. The majority were managed through the transmastoid route with temporalis fascia and calvarial bone graft. Among the patients operated on at least 18 months before analysis, there was a median follow-up of 54 months with no intracranial complications. The average body mass index (BMI) of patients with spontaneous CSF leaks was found to be statistically significantly greater than that of patients with CSF leaks with traumatic, infectious or iatrogenic etiologies. Objectives: To investigate the long-term follow-up of patients with spontaneous, iatrogenic, and traumatic temporal bone encephaloceles and CSF leaks to determine the effective... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4490057 Fri, 11 Feb 2011 00:00:00 +0100 4490057 http://www.medworm.com/index.php?rid=4490060&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21281057%26dopt%3DAbstract Conclusion: This study demonstrates that electric acoustic stimulation (EAS) using the FLEX(EAS) electrode is a successful treatment method for preservation and stability of low frequency hearing, and results in significant improvements in speech perception. Objectives: Low frequency hearing preservation and stability following EAS surgery with the MED-EL PULSARCI(100) implant using the FLEX(EAS) electrode and a combined processor in a multicentre setting, and the efficacy and benefits of EAS over time were evaluated. Methods: Eighteen subjects with normal to moderate hearing loss in the low frequencies and severe to profound hearing loss in the high frequencies were implanted with the FLEX(EAS) electrode. Implantation was performed by different surgeons at three participating centres usin... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4490060 Mon, 31 Jan 2011 00:00:00 +0100 4490060 http://www.medworm.com/index.php?rid=4490059&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21281058%26dopt%3DAbstract Conclusion: We question the justification for the cost of a surgically implanted device for the restoration of limited circumstances of audible communication, although we understand that the decision is taken depending on the social relevance of communication or personal criteria. Objectives: The purpose of this study was to evaluate the effect of the BAHA simulator (BAHAS) system in subjects with acquired unilateral sensorineural hearing loss. In particular we tested the changes of speech reception threshold (SRT) in relation to different speech source positions, with a background of diffuse noise. Methods: The primary message consisting of lists of Italian sentences was delivered from a loudspeaker placed at horizontal azimuths of 0°, 90°, 180° and 270°; the interference consisted of... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4490059 Mon, 31 Jan 2011 00:00:00 +0100 4490059 http://www.medworm.com/index.php?rid=4419656&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21271947%26dopt%3DAbstract Conclusion: There was no evidence of a mean raised vasopressin level in 80 subjects suffering from definite Meniere's disease with positive electrocochleographic findings. There was no correlation with stress. The only group with a mildly raised level comprised those who had had a vertigo attack within a day. The most likely cause is nausea, which is the most potent trigger for vasopressin release. Objective: It has been claimed that patients with Meniere's disease have raised vasopressin levels. This has been linked with a long-standing notion that that there is a link between stress and Meniere's disease, so that an increase in vasopressin could trigger a vertigo attack. Methods: Serum vasopressin concentrations were measured in 80 patients with Meniere's disease whose diagnosis was base... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4419656 Fri, 28 Jan 2011 00:00:00 +0100 4419656 http://www.medworm.com/index.php?rid=4419662&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21254957%26dopt%3DAbstract Authors: Borgstein J PMID: 21254957 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4419662 Mon, 24 Jan 2011 00:00:00 +0100 4419662 http://www.medworm.com/index.php?rid=4419661&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21254958%26dopt%3DAbstract Conclusions: We performed extracapsular dissection (ECD) on 31 patients with pleomorphic adenoma, including 7 deep lobe cases. ECD is minimally invasive and has limited complications compared with other conventional parotidectomy procedures. This is the first report on performance of ECD in patients with deep lobe parotid pleomorphic adenomas. Surgeons who are capsule-conscious can perform ECD with good results. Objective: Pleomorphic adenoma, the most common benign neoplasm occurring in the parotid gland, has a constant frequency of recurrence and facial paralysis in patients after surgery. ECD is one of the surgical procedures performed on patients with these tumors, but its validity is still unclear because of its similarity to enucleation. Methods: We performed ECD in patients with unt... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4419661 Mon, 24 Jan 2011 00:00:00 +0100 4419661 http://www.medworm.com/index.php?rid=4419660&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21254959%26dopt%3DAbstract Conclusion: Pure tone auditory thresholds can change according to duration of interrupted tones in patients with mild to severe psychogenic hearing loss (PHL). Objectives: To examine how the duration of stimulus tones affects the hearing thresholds of patients with PHL. Methods: Twelve patients with PHL (21 ears) were enrolled in this study. We initially measured their hearing thresholds using interrupted tones with a duration of 2 s and equal length of on-time and off-time, 225 ± 35 ms, respectively. After a 10 min interval, we measured their hearing thresholds using the same interrupted tones conditions lasting 5 s. The average threshold gains (2 s thresholds minus 5 s thresholds) were compared to those of 15 control subjects with normal hearing (25 ears), 15 patients with cochlear hear... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4419660 Mon, 24 Jan 2011 00:00:00 +0100 4419660 http://www.medworm.com/index.php?rid=4419659&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21254960%26dopt%3DAbstract Authors: Mohammed ER, Profant M Abstract The diagnosis and management of spontaneous otogenic pneumocephalus with literature review is described. A young sportsman experienced headache and fluctuating mass in his occiput during increased physical activity. A large extradural intracranial pneumocephalus with corresponding emphysema was imaged on a CT scan. Transmastoid identification and plugging of temporal bone defect solved the problem with complete pneumocephalus and emphysema resorption. PMID: 21254960 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4419659 Mon, 24 Jan 2011 00:00:00 +0100 4419659 http://www.medworm.com/index.php?rid=4419658&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21254961%26dopt%3DAbstract Conclusion: A reported mutation in SIX1 was identified in a patient with familial hearing loss (HL), a left preauricular pit, and bilateral enlarged vestibular aqueducts (EVA). Although the characteristic symptoms of EVA including fluctuating HL and repetitive vertigo were not seen in the patient, further studies are needed to clarify the association between EVA and such symptoms. Objectives: To study the audiovestibular functions, and to identify the causative gene in a patient with branchio-oto syndrome. Methods: We enrolled a 30-year-old female in whom HL was pointed out at the age of 6 years. She visited our department at the age of 21 years, and had not experienced any progression of her HL, tinnitus, or vertigo. Pure-tone audiograms showed bilateral moderate mixed HL with no apparent... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4419658 Mon, 24 Jan 2011 00:00:00 +0100 4419658 http://www.medworm.com/index.php?rid=4419657&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21254962%26dopt%3DAbstract Conclusions: Phased-array stimulation is a promising technique, which uses electrical interaction to focus the stimulation in cochlear implants, at the expense of limited threshold shifts. It has potential advantages over, for example, tripolar stimulation. Objectives: Current spread imposes limitations in cochlear implants. Van Compernolle (1985) suggested using all electrode contacts simultaneously to reduce these effects. Van den Honert et al. (2007) validated this so-called phased array algorithm in patients with respect to the electrode potentials but the effect on neural excitation remained unclear. The present study used computational modeling to relate the effect of phased-array stimulation to the neural elements. Methods: A computational model of the implanted human cochlea was us... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4419657 Mon, 24 Jan 2011 00:00:00 +0100 4419657 http://www.medworm.com/index.php?rid=4356496&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21208024%26dopt%3DAbstract Conclusions: With full insertion with a long electrode, hearing preservation can be achieved even in the presence of a long electrode covering the residual hearing region. Objectives: Advances in developing new atraumatic concepts of electrode design as well as surgical technique have enabled hearing preservation after cochlear implantation surgery, and EAS (electric acoustic stimulation) accompanied with hearing preservation is a new trend for patients with residual hearing at the lower frequencies. However, full insertion with a long/medium electrode and hearing preservation is still a challenging field that calls for discussion. Method: In this study, round window insertion, an atraumatic electrode, and dexamethasone administration were used and atraumaticity (hearing preservation and c... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4356496 Wed, 05 Jan 2011 00:00:00 +0100 4356496 http://www.medworm.com/index.php?rid=4356516&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21198340%26dopt%3DAbstract Conclusion: The Esteem device proved to offer beneficial results in subjects suffering from high frequency, severe bilateral sensorineural hearing loss (SNHL) and may be considered as an alternative procedure to conventional hearing aids (HAs) or electroacoustic stimulation (EAS) systems. Objectives: Since the Esteem totally implantable device has been shown to offer positive results among patients with moderate SNHL, this middle ear implant has also been suggested for subjects with a worse degree of hearing loss in order to predict its extended application, also in the nearly cochlear implantation range. Methods: Esteem implantation was carried out in 21 subjects with a mild (n = 3), moderate (MHL, n = 9) or severe (SHL, n = 9) degree of SNHL. The two latter groups, i.e. MHL and SHL, were... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4356516 Mon, 03 Jan 2011 00:00:00 +0100 4356516 http://www.medworm.com/index.php?rid=4356514&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21198341%26dopt%3DAbstract Conclusions: The morphological and morphometric estimation of the dendrites and the dendritic spines in the acoustic cortex in Alzheimer's disease revealed substantial alterations of the dendritic arborization and marked loss of the dendritic spines, which may be related to communication impairment even in early cases of Alzheimer's disease. Objectives: Alzheimer's disease is characterized by progressive loss of memory, impairment of judgment, and decline in communication and speech eloquence. In the present study we attempted to describe the morphological and morphometric alterations of the dendrites and the dendritic spines in the acoustic cortex in early cases of Alzheimer's disease, in order to approach the communication impairment of patients suffering from Alzheimer's disease from a ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4356514 Mon, 03 Jan 2011 00:00:00 +0100 4356514 http://www.medworm.com/index.php?rid=4356512&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21198342%26dopt%3DAbstract Conclusion: Rhinoscleroma is a chronic, specific, granuloma of the nose and other parts of the respiratory system. The disease is endemic in Egypt and many other countries. The causative organism is Klebsiella rhinoscleromatis bacillus, proved by fulfilling Koch's postulates. The mode of infection is not known and its worldwide irregular geographical distribution is not understood. Lines of treatment are unsatisfactory and a tendency for recurrence is the rule. Objectives: Our aim was to study the clinical presentation, microbiology, pathological staging, follow-up, and lines of treatment of new rhinoscleroma patients admitted or seen at Alexandria Main University Hospital from January 1999 until January 2009. Methods: Demographic data and the results of clinical, bacteriological, and hist... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4356512 Mon, 03 Jan 2011 00:00:00 +0100 4356512 http://www.medworm.com/index.php?rid=4356505&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21198343%26dopt%3DAbstract Authors: Masuda T, Kaga K Abstract The influence of aging on hearing and vestibular function in patients with auditory neuropathy has not been investigated. The purpose of this study was to investigate how hearing and vestibular function in this disease change with aging. The subjects were three female patients with auditory neuropathy. We checked their hearing and vestibular function by speech discrimination tests, ABR, ECochG, DPOAE, caloric test, damped-rotational chair test, and VEMPs. In all three patients, speech discrimination ability and vestibular function markedly declined with aging. However, speech language understanding and higher brain function were less affected by aging. PMID: 21198343 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=4356505 Mon, 03 Jan 2011 00:00:00 +0100 4356505