MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Acta Oto-Laryngologica' source. Sat, 20 Mar 2010 14:15:14 +0100 http://www.medworm.com/index.php?rid=3383555&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20235900%26dopt%3DAbstract Conclusion: Moxifloxacin was generally well tolerated and highly effective in the treatment of acute bacterial rhinosinusitis (ABS). The incidence of adverse events (AEs) and adverse drug reactions (ADRs) was low. The effectiveness, safety, and tolerability information collected in this study confirm the clinical safety profile of moxifloxacin and its benefit as a treatment option for ABS. Objective: To assess the effectiveness, safety, and tolerability of moxifloxacin under daily life treatment conditions in patients with ABS. Methods: The study was carried out in China between September 2005 and May 2007. Patients with ABS were treated with moxifloxacin tablets 400 mg once daily for a duration that was left to the physician's discretion. Data were collected on demography, diagnosis of in... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3383555 Wed, 17 Mar 2010 00:00:00 +0100 3383555 http://www.medworm.com/index.php?rid=3383557&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20233013%26dopt%3DAbstract Conclusions: C-reactive protein (CRP) levels may predict the extent of acute rhinosinusitis disease in the computed tomography (CT) scans, as well as the specific symptom severity. High levels may direct the physician to change the treatment. Objective: To establish tools to define 'high risk' patients suffering from acute rhinosinusitis. Methods: Patients suffering from severe unresponsive acute rhinosinusitis filled in health-related quality of life questionnaires and rated their symptoms. Blood tests and CT scans were performed. We examined the value of imaging and inflammatory markers, especially CRP, as predictors of disease severity, defined by subjective and objective means; need for surgery; and occurrence of ocular complications. Results: Thirty-two patients were prospectively rec... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3383557 Tue, 16 Mar 2010 00:00:00 +0100 3383557 http://www.medworm.com/index.php?rid=3383556&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20233014%26dopt%3DAbstract Conclusion: Novel ATP6V1B1 mutations were found in a patient with distal renal tubular acidosis (dRTA), hearing loss (HL), and enlargement of the vestibular aqueduct (EVA). The deterioration of HL and vertiginous attacks may be associated with the disruption of the endolymph pH homeostasis. Objectives: To study the audiovestibular functions and to identify the causative gene. Methods: This study enrolled a Japanese family, where the proband showed type 1 dRTA, early onset HL, and bilateral EVA. A deterioration of HL occurred several times in both ears. Vertiginous attacks were always associated with a deterioration of HL. Audiovestibular examinations included distortion product otoacoustic emissions (DPOAEs), auditory brainstem responses (ABRs), caloric testing, and vestibular evoked myoge... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3383556 Tue, 16 Mar 2010 00:00:00 +0100 3383556 http://www.medworm.com/index.php?rid=3374998&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20230190%26dopt%3DAbstract Conclusion. Endoscopic cauterization of the sphenopalatine artery and anterior ethmoid artery is a first-line standard of care in managing intractable epistaxis, after the failure of previous packing. Epistaxis occurs in 12% of the population. Treatment is often based on nasal packing that could be poorly effective in the treatment of severe posterior epistaxis. Objective. To evaluate the effectiveness of the endoscopic approach for posterior epistaxis. Methods. We report the experience of endoscopic cauterization in two metropolitan hospitals in Italy: 48 patients with at least one nasal packing in the 3 weeks before hospital admission. They underwent endoscopic cauterization of the sphenopalatine artery or of the anterior ethmoid artery. Results. The patients' mean age was 58.7 years; th... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3374998 Mon, 15 Mar 2010 00:00:00 +0100 3374998 http://www.medworm.com/index.php?rid=3363250&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20222848%26dopt%3DAbstract Conclusion: The standard treatment for tuberculous otitis media (TOM) without complications consists of anti-tuberculosis (anti-TB) medication, with which we experienced good treatment outcomes. However, surgery is required for recovery of anatomy and hearing function. Objective: To determine the clinical characteristics of TOM that might optimize diagnosis and to evaluate the differences in clinical courses between patients treated with and without surgery. Methods: We analyzed 14 patients (16 ears) who had been diagnosed and treated for TOM. Radiologic findings, laboratory data, and audiometry results were also evaluated. Patients were divided into a chemotherapy group and a surgery group according to treatment modality. Results: Temporal bone CT (TBCT) showed total occupation of the tym... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3363250 Fri, 12 Mar 2010 00:00:00 +0100 3363250 http://www.medworm.com/index.php?rid=3358700&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20218946%26dopt%3DAbstract Conclusion. Z-palatopharyngoplasty (ZPPP) combined with radiofrequency to the base of tongue (RFBOT) resulted in short-term morbidity only. This study shows the clinical benefits of ZPPP plus RFBOT in patients with moderate/severe obstructive sleep apnea/hypopnea syndrome (OSAHS). Objective. To study the safety and efficacy of ZPPP combined with RFBOT for the treatment of moderate/severe OSAHS. Methods. Charts of all patients with moderate/severe OSAHS who failed or refused CPAP therapy and underwent surgical treatment of ZPPP plus RFBOT were reviewed. The subjective symptoms and objective polysomnographic parameters were collected preoperatively and postoperatively. Postoperative morbidity was recorded. Results. Forty-three OSAHS patients (2 females, 41 males, mean age 39 years) had full ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3358700 Thu, 11 Mar 2010 00:00:00 +0100 3358700 http://www.medworm.com/index.php?rid=3350674&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205620%26dopt%3DAbstract Conclusions: The adenovirus-5 vector specifically transduced spiral ganglion cells with high efficiency, suggesting that it is a potential gene therapeutic tool for the survival of spiral ganglion cells with secondary injury. Objectives: This study aimed to find a suitable viral vector allowing efficient transduction to spiral ganglion cells. Methods: Lentivirus, adeno-associated virus-2 and adenovirus-5 constructs habouring green fluorescence protein (GFP) gene were injected into scala tympani via the round window membrane of rat. Distribution and fluorescence intensity of GFP within the cochlea were estimated using a fluorescence microscope. Results: The GFP expressions mediated by all three viral vectors were observed in multiple cell types of the cochlea. Compared with the other two vi... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3350674 Mon, 08 Mar 2010 00:00:00 +0100 3350674 http://www.medworm.com/index.php?rid=3350673&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20205621%26dopt%3DAbstract Conclusion: Superior semicircular canal dehiscence (SSCD) syndrome may present with various symptoms. CT scans previously interpreted as normal may show SSCD, especially if special reconstructions tailored for superior canal evaluation are added. Objectives: The purpose of this study was to investigate prevalence of SSCD, its length and its correlation with symptoms in patients who had previously undergone temporal bone CT examination that was reported normal and to demonstrate the importance of reformatted images in the diagnosis of SSCD. Methods: We retrospectively reviewed 108 patients who had undergone temporal bone CT examination for various symptoms and were reported as normal. High-resolution temporal bone CT imaging was performed with 1 mm slice thickness in the transverse plane. E... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3350673 Mon, 08 Mar 2010 00:00:00 +0100 3350673 http://www.medworm.com/index.php?rid=3338814&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20201746%26dopt%3DAbstract Conclusion: The study demonstrates that two methods of segmentation, i.e. word and character segmentations, produce equivalent results in the Mandarin Hearing in Noise Test (MHINT). Potentially, both methods of segmentation can be used clinically. A majority of the Mandarin-speaking cochlear implant subjects could complete MHINT - with the more relaxed adaptive rules. The results make it possible to compare the performance of cochlear implant users across languages. Objectives: The primary purpose of the present study was to evaluate the modified adaptive scoring rules and to develop alternative methods of segmentations in MHINT that are suitable for the Chinese language. Methods: Thirty Mandarin-speaking normal-hearing adults were tested with MHINT using three adaptive rules based on char... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3338814 Fri, 05 Mar 2010 00:00:00 +0100 3338814 http://www.medworm.com/index.php?rid=3280673&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20151873%26dopt%3DAbstract Conclusion: The results of our research indicate that (125)I-labelled basic fibroblast growth factor ((125)I-bFGF) has some difficulty in getting across the blood-labyrinth barrier (BLB). Therefore, it is necessary to carry out further study on the route of bFGF administration. Objective: To observe whether bFGF could pass through the BLB after intraperitoneal injection and to establish an experimental basis for its clinical applications. Methods: Thirty guinea pigs were divided into three equal groups. Animals in group 1 were administered (125)I-bFGF, while animals in groups 2 and 3 were given (125)I or saline solution, respectively, via intraperitoneal injection. The animals were sacrificed 2 h later and samples of blood, brain, cochlea, thyroid gland, heart, liver, and kidney were colle... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3280673 Thu, 18 Feb 2010 05:34:08 +0100 3280673 http://www.medworm.com/index.php?rid=3280672&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20151874%26dopt%3DAbstract Conclusion: High risk perforations including total, subtotal, atelectatic perforations, those with cholesteatoma and revision cases can be treated efficiently with cartilage reinforcement tympanoplasty. Objective: The purpose of this study was to describe the perforation closure rates and hearing results of cartilage reinforcement tympanoplasty. Methods: This was a retrospective chart review and included 60 patients who underwent surgery with the cartilage reinforcement technique between November 2006 and October 2008 at the Department of Otorhinolaryngology of Haydarpasa Numune Research and Training Hospital, Istanbul, Turkey. The male to female ratio was 28 (46.7%)/32 (53.3%). The mean age of the patients was 30.10 +/- 11.50 years (range 13-55). Results: Preoperatively, only one patient ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3280672 Thu, 18 Feb 2010 05:34:05 +0100 3280672 http://www.medworm.com/index.php?rid=3270341&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20148752%26dopt%3DAbstract Authors: Qing Z, Min X, Xiaotong Z, Tianying R, Matti A, Maoli D Abstract We here present a 32-month follow-up of a case of Lermoyez syndrome combined with Meniere's disease. The patient was a 49-year-old male, with a stabilized severe hearing loss in the left ear for about 15 years after Meniere's disease. He started to show typical symptoms of Lermoyez syndrome in the right ear about 32 months ago. Audiologic data were obtained and imaging examinations were performed 0, 9, 15, 28, and 32 months after the onset of the Lermoyez syndrome. Pure tone threshold data obtained 5 months before the onset are also reported. The results show that the hearing thresholds, mainly at low frequencies, elevated rapidly during the first months shortly after the onset of the disease and slowly in later ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3270341 Fri, 12 Feb 2010 00:00:00 +0100 3270341 http://www.medworm.com/index.php?rid=3270340&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20148753%26dopt%3DAbstract Conclusion: The results of this study demonstrate that proteomic analysis can be successfully performed on formalin-fixed celloidin-embedded (FFCE) archival human cochlear tissues. Objective: To investigate the feasibility of analyzing protein expression in archival cochlear tissues. Material and methods: A new methodology, referred to as Liquid Tissue(TM), was used to extract proteins from human cochlear tissue sections and spiral ganglion tissue isolated by laser microdissection (LMD). Protein identification was performed by bioinformatic analysis of high resolution tandem mass spectrometric data from fractionated tryptic peptide samples. Results: Twenty-six proteins were identified with a minimum of 2 unique peptides and 450 proteins were identified with 1 unique peptide at a confidence... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3270340 Fri, 12 Feb 2010 00:00:00 +0100 3270340 http://www.medworm.com/index.php?rid=3265090&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20144124%26dopt%3DAbstract Authors: Smith PF, Darlington CL Abstract Dizziness is the most commonly reported symptom of abrupt discontinuation from the selective serotonin reuptake inhibitor (SSRI) category of antidepressants. The reported dizziness is exacerbated by even slight head movement, and therefore is likely to be vestibular in origin. The SSRIs most implicated are those with short half-lives and which are most selective for serotonin (as opposed to noradrenaline), e.g. paroxetine and sertraline. Since the vestibular nucleus complex (VNC) has an abundance of serotonin receptors, the abrupt withdrawal from an SSRI is likely to have a substantial impact on the electrophysiological activity of neurons within it. Here we suggest that the abrupt withdrawal from an SSRI is likely to cause a sudden decrease in... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3265090 Wed, 10 Feb 2010 00:00:00 +0100 3265090 http://www.medworm.com/index.php?rid=3259325&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20141488%26dopt%3DAbstract Conclusion: Acute comparisons between continuous interleaved sampling (CIS) and a temporal fine structure (TFS) coding strategy in Cantonese-speaking cochlear implant (CI) users did not reveal any significant differences in speech perception. Performance with the unfamiliar TFS coding strategy was on a par with CIS. Benefits of extended fine structure use observed in other studies should be investigated for tonal languages. Objectives: CIS-based stimulation strategies lack an explicit representation of fine structure, which is crucial for tonal language speech perception. The aim of this study was to assess speech recognition with a TFS coding strategy in Cantonese-speaking CI users with no prior fine structure experience. Methods: The fine structure coding strategy encodes TFS on a few ap... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3259325 Tue, 09 Feb 2010 00:00:00 +0100 3259325 http://www.medworm.com/index.php?rid=3259324&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20141489%26dopt%3DAbstract Conclusion: The overall results show a high ratio of satisfaction in the sample population, which is in accordance with a successful BAHA counselling and rehabilitation of their hearing impairment. Objectives: The acceptance of a bone anchored hearing aid (BAHA) device by a south European population, which could be expected to have some reticence for wearing this device, has been investigated. Methods: The outcome of BAHA implantation was assessed in 24 patients with bilateral and unilateral hearing loss by administration of several questionnaires, such as the Handicap Hearing Inventory (HHI), Client Oriented Scale of Improvement (COSI), Open and General Glasgow Benefit Inventory and Entific Medical System QoL, along with a complete audiological test battery. Results: Speech reception thre... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3259324 Tue, 09 Feb 2010 00:00:00 +0100 3259324 http://www.medworm.com/index.php?rid=3201979&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20095091%26dopt%3DAbstract CONCLUSIONS: TRPML3 may play distinct roles in the inner ear, such as stereociliar organization, sensory cell transduction, and inner ear fluid homeostasis, and TRPP3 may be important for fluid homeostasis in the inner ear. OBJECTIVE: To study the expression of TRPML1-3 and TRPP2, 3, and 5 in the mouse inner ear. MATERIALS AND METHODS: Localization of TRPML1-3 and TRPP2, 3, and 5 in the inner ear of CBA/J mice was investigated by immunohistochemistry. RESULTS: TRPML1-3 immunoreactivity was evident in the stria vascularis, spiral prominence, and spiral ligament. TRPML immunoreactivity was also observed in outer and inner hair cells, supporting cells, and spiral ganglion cells. The vestibular end organs, vestibular sensory cells, dark cells, and ganglion cells all showed immunoreactivity to ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3201979 Sun, 24 Jan 2010 22:26:13 +0100 3201979 http://www.medworm.com/index.php?rid=3201978&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20095092%26dopt%3DAbstract CONCLUSION: Replacement of vestibular hair cells induced by atoh1 driven by the tissue-specific GFAP promoter was significantly more efficient than use of the cBA or hCMV promoter. OBJECTIVE: To test whether expression level, persistence, or selectivity from adenovirus vectors delivered in the inner ear can be altered by changing the adenovector backbone or by using different cellular and viral promoters. MATERIALS AND METHODS: Adenovector and promoter modifications were tested for differences in transgene expression in adult macular organs. The effect of using an E1/E3 deleted vector was compared to E1/E3/E4 deleted vectors. The effect of using viral and cellular promoters to modify transgene expression was tested in explanted adult mouse macular organs. Based on these results three diffe... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3201978 Sun, 24 Jan 2010 22:26:10 +0100 3201978 http://www.medworm.com/index.php?rid=3201977&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20095093%26dopt%3DAbstract CONCLUSIONS: 11beta-Hydroxysteroid dehydrogenase type 2 (11bHSD-2) enables aldosterone to bind to mineralocorticoid receptors (MRs) selectively by converting cortisol (corticosterone) into inactive metabolites. Its expression in the endolymphatic sac (ES) suggests that aldosterone may selectively act on the ES through its binding to MRs by the action of 11betaHSD-2, and supports the notion that ES is an aldosterone target organ. We propose that 11betaHSD-2 is a dominant isoform of 11betaHSDs in the ES, and the ES (especially the intermediate portion of the ES) may be the main aldosterone target in the inner ear. OBJECTIVE: The purpose of this study was to examine 11bHSD isoform expression in the rat inner ear, mainly 11betaHSD-2 in the ES. MATERIALS AND METHODS: In the ES and whole cochlea... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3201977 Sun, 24 Jan 2010 22:26:06 +0100 3201977 http://www.medworm.com/index.php?rid=3201982&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20092381%26dopt%3DAbstract Conclusions: The longitudinal findings presented in this study suggest that with the maturational development, the conduction time of the auditory nerve decreases while the thresholds had no physiological changes within 0-6 months after birth. Comparing the tone-pip auditory brainstem response (ABR) with the auditory steady-state response (ASSR), the former had lower thresholds than the latter at 500-8000 Hz, which indicates that the estimation of tone-pip ABR maybe nearer to the actual hearing level of infants. Objective: To evaluate the feasibility of tone-pip ABR and ASSR for newborns and infants, and to follow the development of the threshold estimates from tone-pip ABR and ASSR in normal infants through the first 6 months of life. Methods: The tone-pip ABR and ASSR thresholds were mea... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3201982 Thu, 21 Jan 2010 00:00:00 +0100 3201982 http://www.medworm.com/index.php?rid=3201981&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20092382%26dopt%3DAbstract Conclusion: Review of the histopathological changes in the vestibular arch in Ménière's disease, after a study of development of the otic capsule, indicated a severe apoptotic loss of osteoblasts with consequent denudation of these cells from and damage to the osseous canal structure of the arch. Objective: To review previously reported histological findings in the inner layer of the vestibular aqueduct and its intravestibular source in Ménière's disease, using newer knowledge of otic capsule development. Methods: Temporal bone histological sections from the vestibular arch region of eight patients with Ménière's disease were reviewed in our London-based material. Results: Minute granules suggesting apoptotic bodies were found in the arch in the majority of ca... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3201981 Thu, 21 Jan 2010 00:00:00 +0100 3201981 http://www.medworm.com/index.php?rid=3201980&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20092383%26dopt%3DAbstract Conclusion: Chronic suppurative otitis media causes some disturbance to the chorda tympani nerve (CTN), which may affect the facial nerve. It is not possible to perform a biopsy of the main truncus of the facial nerve, therefore studies of the CTN might show possible pathologic or physiologic changes of the facial nerve in the future. Objectives: The specific aim of this study was to investigate the effects of chronic suppurative otitis media on the CTN. Methods: The tympanic segments of CTNs were collected for ultrastructural investigations in patients with chronic suppurative otitis media who underwent canal wall-down tympanoplasty. The study population comprised 10 patients, 7 males, 3 females; the age range was 16-66 years, and the mean age was 38. Qualitative and semiquantitative eval... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3201980 Thu, 21 Jan 2010 00:00:00 +0100 3201980 http://www.medworm.com/index.php?rid=3198246&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20085440%26dopt%3DAbstract Conclusion: Our results show a significant difference between skin and cholesteatoma biology in vitro. Objectives: Cholesteatoma disease is a process of destruction characterized by uncontrolled growth of squamous epithelial cells in the middle ear or temporal bone. The pathophysiology behind the cholesteatoma development is controversial, and the mechanisms driving the cholesteatoma growth, migration and destructive properties is still unclear. We aimed to provide a method to study the effect of various compounds on cholesteatoma and skin tissue growth, as well as to further investigate the biological differences between normal skin and cholesteatoma tissue. Methods: We have established a method to study cholesteatoma biopsy tissue in vitro. Cholesteatoma tissues from patients undergoing ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3198246 Tue, 19 Jan 2010 00:00:00 +0100 3198246 http://www.medworm.com/index.php?rid=3198245&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20085441%26dopt%3DAbstract Conclusions: This study suggests that cytochrome c oxidase subunit 3 (COX 3) expression is diminished in spiral ganglion cells from individuals with presbycusis. In addition to the mitochondrial DNA (mtDNA) common deletion (CD), other deletions involving the mtDNA major arc contribute to the observed deficit in COX 3 expression. Objectives: To assess COX 3 deficiency in spiral ganglion cells from individuals with presbycusis and to determine whether deletions other than the CD contribute to this deficiency. Methods: COX 3 immunofluorescence staining of archival human temporal bone tissue sections from individuals with presbycusis and from age-matched normal-hearing individuals was performed and the intensity of spiral ganglion cell immunostaining was measured. Single COX 3-deficient spiral... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3198245 Tue, 19 Jan 2010 00:00:00 +0100 3198245 http://www.medworm.com/index.php?rid=3198244&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20085442%26dopt%3DAbstract Conclusions: The literature-based meta-analysis confirmed that increased standardized uptake value (SUV) of the primary tumor is a poor prognostic factor in patients with head and neck squamous cell carcinoma (HNSCC), which should be further confirmed in a meta-analysis based on individual patient data. Objectives: Primary tumor SUV, as measured by positron emission tomography (PET), has been studied as a potential prognostic factor for local control, disease-free survival, and overall survival. However, the limited sample sizes of the studies in the past led us to conduct a meta-analysis to improve the precision in estimating the effect of SUV on the prognosis of HNSCC. Methods: Eight articles were identified by searching electronic databases. Statistical analysis was performed with RevMa... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3198244 Tue, 19 Jan 2010 00:00:00 +0100 3198244 http://www.medworm.com/index.php?rid=3190037&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082563%26dopt%3DAbstract Conclusions: The findings demonstrate that an enduring unilateral utricular dysfunction, possibly together with canal hypofunction, can occur after labyrinthine disease or injury. They also suggest that unilateral, isolated utricular dysfunction - or utricle paresis - can occur, representing a novel entity in the differential diagnosis of peripheral vestibular function. The occurrence of subjective visual vertical (SVV) asymmetry in the presence of symmetric vestibular evoked myogenic potentials (VEMPs) also confirms that the information from the utricles, rather than the saccules, dominates SVV estimation. Objectives: To determine the incidence of unilateral utricular hypofunction. Methods: The retrospective clinical study deals with a selection of those vestibular patients who showed pat... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3190037 Mon, 18 Jan 2010 00:00:00 +0100 3190037 http://www.medworm.com/index.php?rid=3190036&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082564%26dopt%3DAbstract Conclusion: Patulous eustachian tube (ET) shows a wide range of manifestations from asymptomatic to severe disturbance in quality of life. Nasal instillation of saline should be attempted as the initial treatment for patulous ET. Objectives: To investigate the effectiveness of nasal instillation of saline as a treatment for patulous ET. Methods: This was a retrospective chart review of 52 patients with patulous ET. They were treated with nasal instillation of saline, followed by assessment of subjective improvement after 2-8 weeks. Results: The age distribution of the patients with patulous ET revealed two peaks, one with female predominance in the fourth decade, the other consisting mostly of aged male patients. Nasal instillation of saline was effective in 33 (63.5%) of 52 patients with ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3190036 Mon, 18 Jan 2010 00:00:00 +0100 3190036 http://www.medworm.com/index.php?rid=3190035&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082565%26dopt%3DAbstract Conclusion: A modified paraffin-embedding method could be applied to histopathological and immunohistochemical studies of the human cochlea. The complementary use of molecular and immunohistochemical techniques by means of this method is thus considered to be a valuable tool for the future study of the human inner ear. Objective: To propose a new paraffin-embedding method for the morphological and immunohistochemical study of the human cochlea. Methods: Five human temporal bones were harvested at autopsy. The temporal bone specimens were fixed in 20% buffered formalin, decalcified with EDTA, cropped to a cube of approximately 15 mm, embedded in paraffin, and then cut into 6 mum thick sections. The sections were stained with hematoxylin and eosin, and immunostained with anti-prestin and ant... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3190035 Mon, 18 Jan 2010 00:00:00 +0100 3190035 http://www.medworm.com/index.php?rid=3190034&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082566%26dopt%3DAbstract Conclusion: There is no change in the total cell population and hair cell:supporting cell ratio in the human utricular macula from gestational week 16 and onwards, whereas the lower hair cell:supporting cell ratio and lower total number of cells in the youngest specimens indicate that the utricle is still differentiating and adding new cells at the 10th to 12th gestational week. Objectives: Archival temporal bones were investigated to quantify cell numbers in the utricular macula in fetuses and children. Methods: The age of the subjects ranged from gestational week 10 to 15 years. The optical fractionator was used to estimate the total number of cells in the utricular macula. Results: The total cell number was found to be 143 000 in subjects older than gestational week 16. The number of ha... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3190034 Mon, 18 Jan 2010 00:00:00 +0100 3190034 http://www.medworm.com/index.php?rid=3190033&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082567%26dopt%3DAbstract Conclusion: Watch-PAT may provide an accurate and clinically effective portable monitoring method for the diagnosis of obstructive sleep apnea (OSA). Objective: This study was designed to assess the accuracy and clinical efficacy of a wrist-worn portable device (Watch-PAT 100) to diagnose OSA. Methods: Twenty-seven participants with suspected OSA underwent full polysomnography (PSG). Finally, 25 subjects successfully underwent portable monitoring using Watch-PAT after full PSG. The study population consisted of 21 males and 4 females, mean age 40.9 +/- 11.2 years (range 21-59). Mean body mass index (BMI) was 26.2 +/- 2.6 kg/m(2) (range 21.2-32.3). All PSG were manually scored according to the new scoring manual of the American Academy of Sleep Medicine (2007) and the Watch-PAT data were an... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3190033 Mon, 18 Jan 2010 00:00:00 +0100 3190033 http://www.medworm.com/index.php?rid=3190032&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082568%26dopt%3DAbstract Conclusion: The test is simple and sensitive enough to separate normal subjects from patients suffering from a vestibular loss. There was also a good correlation between the objective results and the subjective complaint of oscillopsia. Objectives: Oscillopsia (i.e. blurred vision while walking) is often reported by patients suffering from vestibular loss. We developed a test to quantify oscillopsia. Methods: Visual acuity was determined in 16 normal subjects and in 8 patients suffering from a bilateral vestibular loss, at rest and while walking at increasing speed on a treadmill. Snellen optotypes were randomly projected on a screen and the visual acuity was determined with an adaptative staircase algorithm. Results: In normal subjects, the visual acuity did not decrease markedly during w... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3190032 Mon, 18 Jan 2010 00:00:00 +0100 3190032 http://www.medworm.com/index.php?rid=3190031&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082569%26dopt%3DAbstract Conclusion: Reactive oxygen species (ROS) and the c-Jun N-terminal kinase (JNK) signaling pathway may be involved in secondary apoptosis of spiral ganglion cells (SGCs) induced by intracochlear gentamicin injection. Objectives: The purpose of this study was to ascertain the role of ROS and the JNK signaling pathway in secondary apoptosis of SGCs induced by intracochlear gentamicin treatment. Methods: Gentamicin (40 mg/ml) was injected into the cochlea of guinea pigs (n = 18) to destroy the hair cells and induce secondary apoptosis of SGCs. At 1 (n = 6), 2 (n = 6), and 3 (n = 6) weeks after gentamicin treatment, the cochleas were removed and stained with hematoxylin and eosin, and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling to observe the morphologic changes... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3190031 Mon, 18 Jan 2010 00:00:00 +0100 3190031 http://www.medworm.com/index.php?rid=3190030&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082570%26dopt%3DAbstract Conclusion: The external neck brace (ENB) is a new concept in the improvement of peristomal fixation of an automatic stoma valve (ASV), which was evaluated with a new imaging method. The addition of the ENB to the Flexiderm (FLD) and Xtrabase (XB) adhesives significantly reduced absolute mean differences between the speech and the non-speech conditions. Objectives: After total laryngectomy, peristomal fixation problems of adhesives and stoma valves are still the main reasons for the relatively small number of patients that actually use an ASV on a daily basis. Several concepts could not prevent these fixation problems. To overcome or at least diminish these attachment problems, an ENB has been developed to support peristomal adhesives. The mechanism behind this brace is that it absorbs the... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3190030 Mon, 18 Jan 2010 00:00:00 +0100 3190030 http://www.medworm.com/index.php?rid=3190029&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082571%26dopt%3DAbstract Conclusions: Results of the current study revealed improved phonation threshold pressure (PTP), normalized mucosal wave amplitude (NMWA), and less contraction of the lamina propria in injured larynges treated with basic fibroblast growth factor (bFGF). Objectives: We investigated the effects of local injection of bFGF for treatment of acute vocal fold injury in a canine model. Methods: Vocal folds of eight beagles were unilaterally injured by removal of the mucosa under direct laryngoscopy. Four beagles received local injections of bFGF delivered to the scarred vocal fold at 1 month after injury. The remaining four beagles received local injections of saline and served as a sham-treatment group. Larynges were harvested 5 months after treatment and excised larynx experiments were performed ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3190029 Mon, 18 Jan 2010 00:00:00 +0100 3190029 http://www.medworm.com/index.php?rid=3190039&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082558%26dopt%3DAbstract Conclusion. Semicircular canal occlusion after completely removing cholesteatoma matrix is a safe and effective approach for treatment of labyrinthine fistula. Objective. To investigate the safety and efficacy of semicircular canal occlusion for surgical treatment of labyrinthine fistula caused by cholesteatoma. Patients and methods. Twenty-two patients with labyrinthine fistula who were treated surgically were enrolled in the study. All patients were treated by completely removing the cholesteatoma matrix followed by semicircular canal occlusion. Results. With a follow-up of at least 6 months, there was no recurrent cholesteatoma in any of the patients. Vertigo disappeared in all the patients. Most patients presented no hearing detriment and four of them demonstrated hearing improvement. ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3190039 Fri, 01 Jan 2010 00:00:00 +0100 3190039 http://www.medworm.com/index.php?rid=3190038&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20082559%26dopt%3DAbstract We report on the case of a 15-year-old patient with active bleeding via the oral cavity, headache, and later hematoma in the cervical region. Arteriography demonstrated a pseudoaneurysm of the internal carotid artery. Angiography demonstrated successful embolization after the placement of coils and thus endovascular procedures are an alternative treatment for pseudoaneurysms of the internal carotid arteries in adolescents. PMID: 20082559 [PubMed - in process] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3190038 Fri, 01 Jan 2010 00:00:00 +0100 3190038 http://www.medworm.com/index.php?rid=3101358&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20001444%26dopt%3DAbstract Conclusions: The investigated studies disclose a large variability of the many symptoms appearing in the course of Menière's disease. Objectives: To analyze the data of 46 mostly retrospective studies (with a total of 7852 patients). Methods: We present a short overview of the literature on the long-term course of Menière's disease. Special emphasis is placed on the most relevant and distressing symptoms of these patients, such as vertigo attacks, vestibular and hearing function, drop attacks, and the probability of transition from unilateral to bilateral involvement. Results: The frequency of vertigo attacks diminishes within 5-10 years. Hearing loss (of about 50-60 dB) and vestibular function decrement (of about 35-50%) take place mainly in the first 5-10 years of disease. Drop... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3101358 Thu, 10 Dec 2009 00:00:00 +0100 3101358 http://www.medworm.com/index.php?rid=3101357&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20001445%26dopt%3DAbstract Conclusion: Both the regularly used heat and moisture exchanger (R-HME) and the HME with both an antimicrobial and hygroscopic element (F-HME) are effective moisture exchangers. The antimicrobial filter of the F-HME acts as a heat exchanger. The external features of the F-HME were experienced as inconvenient, but decreased sputum production was reported as well. Objectives: Recently an HME with an integrated antimicrobial filter has become available for use in laryngectomized patients. The purpose of this study was to assess its short-term endotracheal climate changes and feasibility in daily practice. Methods: Endotracheal temperature and humidity were successfully measured in 13 laryngectomized patients (2652 analysed full breaths), during 10 min rest-breathing with the R-HME, with an F-... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3101357 Thu, 10 Dec 2009 00:00:00 +0100 3101357 http://www.medworm.com/index.php?rid=3068085&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19968606%26dopt%3DAbstract Conclusion: This study documents that otosclerotic bone remodeling is distributed centripetally around the inner ear space whereas normal bone remodeling is distributed centrifugally. We suggest that this inverse relation reflects the unique osteo-dynamic setting of the otic capsule: since perilabyrinthine bone remodeling is extremely low, osteocyte deficiency and microcracks accumulate in excess toward the inner ear space with age. This may disrupt the osseus functional network, impede propagation of anti-resorptive signals, and precipitate otosclerotic bone remodeling with a spatial preference for older bone. Objective: To quantify the spatial distribution of otosclerotic bone around the inner ear space in order to explore a possible spatial relation with normal capsular bone remodeling.... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3068085 Tue, 08 Dec 2009 00:00:00 +0100 3068085 http://www.medworm.com/index.php?rid=3068084&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19968607%26dopt%3DAbstract Conclusion: Patients with upper airway narrowing at the soft palate level and partial upper airway obstruction during sleep seem to benefit from laser-assisted uvulopalatoplasty (LUPP) in terms of decreased velopharyngeal collapsibility and improved nocturnal breathing. Objectives: The current operative treatments for obstructive sleep apnea syndrome (OSAS) are not very effective compared with continuous positive airway pressure (CPAP). It has been suggested that active treatment should be performed earlier, when sleep apnea is present in a milder form. The main problem is identifying progressive sleep apnea. The present study assessed the efficacy of LUPP in patients with partial upper airway obstruction during sleep diagnosed by means of a static charge-sensitive bed (SCSB) combined with... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3068084 Tue, 08 Dec 2009 00:00:00 +0100 3068084 http://www.medworm.com/index.php?rid=3068083&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19968608%26dopt%3DAbstract Conclusions: In our experience, monolateral or bilateral infrahyoid myocutaneous flap is less time-consuming and reduces the complication rate and the operation time in both small and large defects if compared with other authors' experience using a microvascular anastomosed flap. Objective: The aim of this study was to describe our results in reconstructive surgery after cancer ablation using the less popular infrahyoid myocutaneous flap as an alternative method to free flaps. The surgical technique and the postoperative outcomes are described. Methods: This was a retrospective study: 32 patients with squamous cell carcinoma of the tongue were surgically treated using a pure infrahyoid myocutaneous neurovascular flap. Results: The flap was successful in all cases without flap necrosis, fis... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3068083 Tue, 08 Dec 2009 00:00:00 +0100 3068083 http://www.medworm.com/index.php?rid=3068082&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19968609%26dopt%3DAbstract Conclusion: The low incidence of metastases in levels I and IIB in patients with hypopharyngeal cancer in cases of clinical N0 and N+ neck and the fact that all patients with metastases in levels I and IIB received postoperative radiotherapy justifies the preservation of levels I and IIB in patients with hypopharyngeal cancer to improve functional results and reduce the operating time. Objectives: Neck dissection of levels I and IIB is technically demanding due to the complex local anatomy and can cause several comorbidities. Therefore the aim of the study was to analyze whether levels I and IIB have to be dissected in patients with hypopharyngeal cancer. Methods: This was a retrospective analysis of all patients who underwent primary surgical treatment for hypopharyngeal cancer and neck d... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3068082 Tue, 08 Dec 2009 00:00:00 +0100 3068082 http://www.medworm.com/index.php?rid=3060014&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958241%26dopt%3DAbstract Conclusions: The results of this study suggest that atypical bacteria may be involved not only in acute upper airway diseases but also in recurrent infections requiring adenoidectomy and/or tonsillectomy. Therefore, their identification, followed by an appropriate treatment, should be considered. Objective: Although viruses and group A beta-haemolytic streptococci (GABHS) represent the most frequent bacterial aetiological agents of paediatric upper respiratory tract infections (URTIs), chlamydia and Mycoplasma pneumoniae have also been found in acute tonsillopharyngitis. Nevertheless their relevance in chronic or recurrent URTI has never been evaluated. This study aimed to further address the role of atypical bacteria in recurrent URTIs requiring adenoidectomy and tonsillectomy. Methods: S... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060014 Fri, 04 Dec 2009 00:00:00 +0100 3060014 http://www.medworm.com/index.php?rid=3060013&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958242%26dopt%3DAbstract Conclusion: 3 Tesla (3T) magnetic resonance imaging (MRI) performed 4 h after intravenous gadolinium (Gd) injection provides sufficient anatomic resolution of the inner ear fluid spaces in sudden deafness. The signal intensity ratio (SIR) between the cochlea and cerebellum may be a good indicator of disruption of the blood-labyrinthine barrier. Objectives: We evaluated the inner ear 4 h after intravenous Gd injection to determine whether 3T MRI enables the acquisition of images of the affected inner ear in sudden deafness. Methods: Ten patients underwent 3T MRI scanning 4 h after intravenous Gd injection. Three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) MRI was performed. Results: The SIR varied from 0.45 to 2.17 in 11 affected ears and from 0.43 to 1.48 in 9 unaffected ear... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060013 Fri, 04 Dec 2009 00:00:00 +0100 3060013 http://www.medworm.com/index.php?rid=3060012&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958243%26dopt%3DAbstract Conclusion. Dysequilibrium is one of the most important side effects of ear surgery. The subjective visual vertical can be used as a good indicator for the evaluation of otolithic function in patients with ear surgery. Objective. To investigate the influence of various types of ear surgery on the otolithic organs. Methods. Seventy-one patients underwent ear surgery. Subjective visual vertical (SVV) test was performed before and after ear surgery. We investigated the directional changes of SVV before and after the ear surgery. Results. The postoperative SVV of two patients who underwent translabyrinthine removal of vestibular schwannoma shifted toward the operated side, but following other surgical procedures the SVV tended to shift toward the healthy side. PMID: 19958243 [PubMed - as s... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060012 Fri, 04 Dec 2009 00:00:00 +0100 3060012 http://www.medworm.com/index.php?rid=3060011&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958244%26dopt%3DAbstract Conclusion: Collagen deposition was increased in regenerative rabbit maxillary mucosa, and the elevated collagen deposition during wound healing was associated with increased interleukin (IL)-6 and IL-8, and decreased IL-10. Objectives: To observe the natural progression of wound healing in rabbit maxillary sinus mucosa and to detect the expression of relevant cytokines. Methods: A rabbit wound-healing model was established in the maxillary sinus. At different times after injury, the sizes of maxillary ostia were recorded, and histological changes in the sinus mucosa were examined by means of hematoxylin and eosin (H&E) and Masson trichrome staining. Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentrations of IL-6, IL-8, IL-10, and collagen types I and III. Resul... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060011 Fri, 04 Dec 2009 00:00:00 +0100 3060011 http://www.medworm.com/index.php?rid=3060010&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958245%26dopt%3DAbstract Conclusion: The approach to the cochlea did not influence postural control after cochlear implantation (CI) surgery. Most patients already have impaired vestibular function before surgery. These balance deficits did not change after CI surgery in the majority of patients but static balance might be improved by CI surgery. Objectives: To determine whether the technique used to insert the CI electrode has an influence on vestibular function. Methods: Static and dynamic postural control and caloric vestibular function were measured prospectively before and after CI surgery in 36 CI patients with standard cochleostomy (SC) insertion and 16 patients with insertion across the round window (RW). The test battery consisted of the modified clinical test of sensory interaction on balance (mCTSIB), t... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060010 Fri, 04 Dec 2009 00:00:00 +0100 3060010 http://www.medworm.com/index.php?rid=3060009&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958246%26dopt%3DAbstract Conclusion: A hole in the vestibule of the inner ear leads to augmentation of the hearing loss following noise exposure. Further research is needed to ascertain the mechanism. Objectives: The possible effects of a hole in the wall of the inner ear at the vestibule on noise-induced hearing loss were assessed. Methods: The study was conducted on a total of 14 sand rats. Of these 14 animals, 10 underwent baseline auditory nerve and brainstem evoked response (ABR) threshold measurements in each ear separately (insert earphone), opening of middle ear bulla in both ears and drilling of a hole in the vestibule of one inner ear. The other ear was sham-operated. Following immediate re-assessment of ABR threshold, the 10 animals were exposed to 113 dB SPL broadband noise during 4 nights, and 3 days ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060009 Fri, 04 Dec 2009 00:00:00 +0100 3060009 http://www.medworm.com/index.php?rid=3060008&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958247%26dopt%3DAbstract Conclusion: The CustomSoundEP software can record ECAP traces in an automated manner and calculate the ECAP threshold from them. These values are in good agreement with those determined by audiologists. Manual optimization measurements, as needed when using the predecessor version 3 of the software, are done by the software itself in the newer system. Objectives: The programming of a cochlear implant speech processor is usually carried out in a subjective manner, influenced by the audiologist and the subject, and it takes considerable time. With increasing numbers of patients there is a growing need for a rapid and reliable technique to measure and analyse neural responses - one which could give suggestions for programming the speech processor and thus shorten the fitting procedure. Method... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060008 Fri, 04 Dec 2009 00:00:00 +0100 3060008 http://www.medworm.com/index.php?rid=3060007&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958248%26dopt%3DAbstract Conclusion: The present study demonstrates a very strong effect of the parental communication mode on the auditory capabilities and speech/language outcome for cochlear implanted children. The children exposed to spoken language had higher odds of scoring high in all tests applied and the findings suggest a very clear benefit of spoken language communication with a cochlear implanted child. Objectives: The aim of the study was to identify factors associated with speech and language outcomes for cochlear implanted children and also to estimate the effect-related odds ratio for each factor in relation to the children's speech and language performances. Methods: Data relate to 155 prelingually deafened children with cochlear implant (CI). A test battery consisting of six different speech and ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060007 Fri, 04 Dec 2009 00:00:00 +0100 3060007 http://www.medworm.com/index.php?rid=3060006&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958249%26dopt%3DAbstract Conclusion: In this comparative series, hearing results were superior with titanium compared with autograft ossiculoplasty in the absence of a stapes superstructure. However, in the presence of a stapes superstructure, titanium ossiculoplasties gave superior results to autografts only when comparing an air-bone gap of < 10 dB. Objective: To compare the hearing outcomes of autograft versus titanium ossiculoplasty at 1 year. Methods: Two consecutive groups of patients with chronic suppurative otitis media with and without cholesteatoma suitable for ossiculoplasty, either primarily or as a staged procedure, were recruited for the study. A total of 52 consecutive patients who underwent an autograft ossiculoplasty were compared with 51 consecutive patients who underwent a titanium ossiculopl... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060006 Fri, 04 Dec 2009 00:00:00 +0100 3060006 http://www.medworm.com/index.php?rid=3060005&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958250%26dopt%3DAbstract Conclusion: Cochlear implantation is a safe procedure in experienced hands, as the rate of severe complications is below 2%. Complications differ between children and adults, and transient disequilibrium/vertigo is the most common complication, followed by wound infection, haematoma/oedema and transient chorda tympani syndrome. An international consensus on the reporting of complications is proposed, as a high degree of variability occurs in the literature, which precludes an overview necessary for adequate patient information and for incentives aimed at prevention. Objective: To report unexpected findings and surgical complications in 505 consecutive cochlear implantations, and propose a consensus for reporting complications. Methods: This was a retrospective file review of 367 consecutiv... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060005 Fri, 04 Dec 2009 00:00:00 +0100 3060005 http://www.medworm.com/index.php?rid=3060004&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958251%26dopt%3DAbstract Conclusion: The Korean version of the Clinical Assessment of Music Perception (K-CAMP) test is an efficient, self-administrable test for discrimination of a wide range of music perception ability in adult Korean cochlear implant (CI) users. Objectives: The aims of the study were the development of a clinically practical test of music perception for adult Korean CI lisetners and evaluation of its effectiveness. Methods: Twelve adult post-lingually deafened patients and 12 normal-hearing (NH) controls were tested with the K-CAMP test, comprising pitch direction discrimination, melody identification, and timbre identification tests. Results: Pitch discrimination, melody identification, and timbre identification in CI users showed a wide range of perceptual abilities. The mean pitch change dis... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060004 Fri, 04 Dec 2009 00:00:00 +0100 3060004 http://www.medworm.com/index.php?rid=3060003&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958252%26dopt%3DAbstract Conclusion: The cupula shows various degrees of changes after gentamicin (GM) injection into the inner ear, with or without damage of the sensory cells. This cupula change may be a part of the etiology of peripheral vertigo, and is also potentially one of the mechanisms of reduced caloric response. Objectives: To observe the morphological changes of the cupula after injecting GM in the frog inner ear and to compare the changes of the cupula with those of the ampullary sensory cells. Methods: We injected 300 mug (7.5 mul) of GM into the inner ear of 30 bullfrogs (Rana catesbeiana) using a microsyringe under ether anesthesia. The same amount of saline was injected into the other ear as control. The cupulae were observed at 3, 7, and 14 days after GM injection by stereoscopic microscope. The ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3060003 Fri, 04 Dec 2009 00:00:00 +0100 3060003 http://www.medworm.com/index.php?rid=3013178&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922080%26dopt%3DAbstract Conclusions. klotho protein content decreases with increasing age, which weakens resistance to oxidative stress, resulting in induced cell death as well as modulating endolymph fluid homeostasis. Down-regulation of klotho also leads to down-regulation of TRPV5 and TRPV6, resulting in modified Ca(2 +) homeostasis in the inner ear, dysfunction of sensory cell transduction and causing hearing loss and/or vestibular disorders. Objective. Expression of klotho, TRPV5 and TRPV6 in the mouse inner ear and age-related changes were analysed. Materials and methods. CBA/J mice aged 8 weeks and 24 months were used in this study. The localization of klotho, TRPV5 and TRPV6 in the inner ear of young and old mice was investigated by immunohistochemistry. Results. Immunostaining for klotho was observed in ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013178 Sat, 21 Nov 2009 00:08:03 +0100 3013178 http://www.medworm.com/index.php?rid=3013177&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922081%26dopt%3DAbstract Conclusion: It is suggested that TRPCs play a functional role in the sensory cell transduction system in the inner ear. Objective: To study expression of TRPC 1-7 in the mouse inner ear. Materials and methods: The localization of TRPC 1-7 in the inner ear of CBA/J mice was investigated by immunohistochemistry. Results: TRPC immunoreactivity was observed generally in the inner ear, e.g. in the lateral wall of the cochlea, organ of Corti, spiral ganglion, vestibular end organs and vestibular ganglion. The immunofluorescent reaction to TRPC 3, 4, 5, and 7 in the stria vascularis was more intense than in the spiral prominence or spiral ligament. In the organ of Corti, TRPC immunoreactivity was observed in the outer hair cells (OHCs), inner hair cells (IHCs) and some supporting cells. TRPC 1-7 ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013177 Sat, 21 Nov 2009 00:08:03 +0100 3013177 http://www.medworm.com/index.php?rid=3013176&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922082%26dopt%3DAbstract Conclusions: Mouse cochleae are highly resistant to systemicallyadministered cisplatin. However, cochlear lesions can be produced effectively in mice when cisplatin is applied locally through the round window niche or tympanum. Objective: To explore the optimal approach for creating cisplatin-induced cochlear lesions in mice. Materials and methods: Cisplatin was administered to adult C57BL/6J mice via four approaches: (1) transtympanic injection, (2) round window niche injection, (3) intraperitoneal injection (i.p.) at 4 mg/kg/day for 4 consecutive days, and (4) one 15 mg/kg dose i.p. The hearing was monitored using frequency-specific auditory brainstem responses (ABRs) and distortion-product otoacoustic emissions (DPOAEs). Cochlear pathology was observed in cochleograms with Harris' hemat... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013176 Sat, 21 Nov 2009 00:08:03 +0100 3013176 http://www.medworm.com/index.php?rid=3013175&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922083%26dopt%3DAbstract Conclusions: Although it abolishes the incudostapedial joint, use of glass ionomer cement to repair the defect between the stapes head and the long process of the incus is a successful procedure when the hearing results are considered. Objectives: To compare the hearing results obtained by a fixed, stiff reconstruction with glass ionomer cement, and a flexible, springy pseudo-joint built with autologous cortical bone in patients with a small defect between the long process of the incus and the stapes head. Patients and methods: A total of 66 patients who had canal wall up tympanomastoidectomy due to chronic otitis media and incus long process defect between January 1996 and February 2008 were analyzed retrospectively. Their incudostapedial joints were reconstructed using either glass ionom... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013175 Sat, 21 Nov 2009 00:08:03 +0100 3013175 http://www.medworm.com/index.php?rid=3013174&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922084%26dopt%3DAbstract Conclusion: Surgical treatment of fibrous dysplasia of the temporal bone (TBFD) revealed relatively good outcomes. Also, active surgical intervention is necessary to prevent the formation of secondary cholesteatoma or other complications. In particular, FD involving the inner ear may require greater caution when deciding on the resection area and timing of surgery. Objectives: The purpose of this study was to analyze clinical manifestations of TBFD and its surgical outcomes. Patients and methods: Nine patients diagnosed with TBFD after surgery at three tertiary referral centers were included. Pre- and postoperative clinical, audiological, and radiological findings were analyzed retrospectively. Results: Most patients (88.9%) showed FD involving the mastoid and adjacent area. Radiological p... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013174 Sat, 21 Nov 2009 00:08:03 +0100 3013174 http://www.medworm.com/index.php?rid=3013173&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922085%26dopt%3DAbstract Conclusion: At the time of birth, the incudo-mallear joint is completely developed. Objective. To study the development of the incudo-mallear joint in human embryos and fetuses. Materials and methods. In all, 46 temporal bones with ages between 9 mm and newborns were studied. The preparations were cut in a series and dyed using Martins' trichrome technique. Results. The incudo-mallear joint acquires the characteristics of a saddle joint at 10 weeks of development. The cartilage that covers the articular surfaces is formed by different strata that develop successively: the superficial stratum at 14 weeks, the transitional between 15 and 19 weeks, and the radial from 20 weeks. The subchondral bone develops between weeks 25 and 28 by the mechanisms of apposition and extension of the periostea... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013173 Sat, 21 Nov 2009 00:08:03 +0100 3013173 http://www.medworm.com/index.php?rid=3013172&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922086%26dopt%3DAbstract Conclusion: Although we have shown that malleus handle and mucosal factors were important prognostic factors for hearing, we were unable to show the positive effect of the stapes superstructure on hearing results. The positive effect of the presence of the stapes superstructure on hearing results is closely related to the quality of the mucosa. Objective: The aim of this study was to investigate the impact of ossicular and mucosal factors on hearing in primary canal wall down (CWD) surgery with ossicular chain reconstruction (OCR) performed for extensive acquired cholesteatoma. Patients and methods: A total of 134 adults who had CWD surgery with OCR for extensive acquired cholesteatoma between January 1996 and May 2007 were retrospectively analyzed. Results: The graft insufficiency was 13%... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013172 Sat, 21 Nov 2009 00:08:03 +0100 3013172 http://www.medworm.com/index.php?rid=3013171&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922087%26dopt%3DAbstract Conclusion: In agreement with previously published findings, our results demonstrate that Pelizaeus Merzbacher disease (PMD) does not affect the development and morphology of the peripheral vestibulo-cochlear system. Objective: PMD is a consequence of X-linked mutation of the main central nervous system (CNS) myelin protein resulting in a complex neurological syndrome. Otorhinolaryngological symptoms include nystagmus and alterations of auditory-evoked brainstem responses. To date no histopathological analysis of the inner ear has been performed. Materials and methods: The temporal bone morphology of an affected fetus was examined with light microscopy and synchrotron radiation-based micro computed tomography. Results: The regular structure of the vestibulo-cochlear system was shown in thi... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013171 Sat, 21 Nov 2009 00:08:03 +0100 3013171 http://www.medworm.com/index.php?rid=3013170&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922088%26dopt%3DAbstract Conclusions: The nystagmus recorded without visual fixation contained all three components in most patients with vestibular neuritis (VN). The nystagmus was unidirectional, strongly visually suppressed with the loss of vertical component in most patients, and it obeyed Alexander's law. Video-oculography (VOG) is a non-invasive tool for detailed analysis of nystagmus, and hence may improve differential diagnostics in dizzy patients. Objective: To characterize three-dimensional nystagmus findings in patients with acute VN using the VOG technique. Patients and methods: A prospective study in 16 patients with VN was carried out in a tertiary referral centre. Nystagmus was measured on average 3 days after the beginning of symptoms. Subjective assessment of dizziness and quality of life was perf... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013170 Sat, 21 Nov 2009 00:08:03 +0100 3013170 http://www.medworm.com/index.php?rid=3013169&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922089%26dopt%3DAbstract Conclusion: No significant changes in hearing thresholds were observed during vertigo attacks associated with Meniere's disease. Objectives: To determine if the hearing alters during the period of the attacks of vertigo in Meniere's disease. Patients and methods: The study group consisted of patients who had a clinical diagnosis of definite Meniere's syndrome according to the AAOOHNS criteria, a score on the Gibson scale of 7 or over and an enhanced negative summating potential on transtympanic electrocochleography. These patients were supplied with a programmable hearing aid and a portable programmer that allowed them to measure their own hearing in situ. They were asked to measure their audiometric thresholds daily and if possible during the attacks of vertigo. Results: Six of the patien... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013169 Sat, 21 Nov 2009 00:08:03 +0100 3013169 http://www.medworm.com/index.php?rid=3013168&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922090%26dopt%3DAbstract Conclusion: Selected patients with Meniere's disease (MD) show an improvement of disability from vertigo after transtympanic ventilation tube insertion, although an effect on vestibular function is not seen if ipsilateral middle ear pressure lower than -50 daPa is used as a selection criterion. Objectives: Transtympanic ventilation tube insertion as a treatment option for MD has been reported but its results have been controversial. So far, no investigations on vestibular function in patients with MD after tube insertion have been carried out. Subjects and methods: Twenty-two patients with unilateral MD who were intractable to medical treatment and who had an ipsilateral middle ear pressure lower than -50 daPa received a transtympanic ventilation tube. Vestibular evoked myogenic potentials... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013168 Sat, 21 Nov 2009 00:08:03 +0100 3013168 http://www.medworm.com/index.php?rid=3013167&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922091%26dopt%3DAbstract Conclusions: Three possible results are commonly seen after ice-water caloric irrigation and to correctly interpret them the function of the corresponding vestibular receptor and of normal endolymphatic flow must be taken into account. Bedside vestibular examination helps to interpret discrepant findings. Objective: To review the findings obtained with the ice-water caloric test in patients with dizziness and to compare the results with those of the bedside test. Patients and methods: The study was undertaken in a university hospital, tertiary medical center. The indications to perform the ice-water caloric test were: 1) unilateral canal weakness >90%; 2) a maximum slow phase velocity of nystagmus after hot (44 degrees C) and cold (30 degrees C) caloric stimulation in either ear of <... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013167 Sat, 21 Nov 2009 00:08:03 +0100 3013167 http://www.medworm.com/index.php?rid=3013166&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922092%26dopt%3DAbstract Conclusions: Administration of high-dose gentamicin for intractable Meniere's disease appears to be effective in achieving long-term control of vertigo. However, the safety of this route of administration with respect to the patient's hearing has not yet been sufficiently established. Objectives: The study aimed to analyze the long-term results of patients receiving high-dose intratympanic gentamicin (ITG) instillation for refractory Meniere's disease. Patients and methods: Fourteen patients with Meniere's disease according to 1995 American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) guidelines who had failed medical (12 subjects) or surgical (2 subjects) treatment were included. Intratympanic injections of 27 mg/ml gentamicin were performed three times daily for 4 days. Vert... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013166 Sat, 21 Nov 2009 00:08:03 +0100 3013166 http://www.medworm.com/index.php?rid=3013165&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922093%26dopt%3DAbstract Conclusion: As virtual channels could be perceived by the majority of implant users, they promise potential for advanced speech coding strategies, providing enhanced spectral resolution. An improvement in resolution was found from first stimulation up to 6 months afterwards. Objective: Independent current sources allow distribution of the current between adjacent electrode contacts in a defined ratio, thus steering the current. The goal of our study was to investigate a) whether all users were able to distinguish between adjacent physical channels, b) how many users could perceive a distinct pitch as the current was steered between two adjacent contacts and c) whether a learning effect was observed. Subjects and methods: A pitch ranking measurement was performed during an acute test sessio... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013165 Sat, 21 Nov 2009 00:08:03 +0100 3013165 http://www.medworm.com/index.php?rid=3013164&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922094%26dopt%3DAbstract Conclusion: Young and middle-aged women with Turner syndrome (TS) have a progressive type of hearing impairment, deteriorating rapidly in adult age. The hearing decline seems to consist of two patterns: a mid-frequency dip, likely of a genetic origin, and a high-frequency loss resembling age-related hearing impairment - possibly influenced by estrogen deficiency. Objectives: This was a longitudinal study of hearing thresholds in a group of women with TS that also aimed to determine whether the factors initial age, initial hearing level, karyotype, and presence/absence of a mid-frequency dip influence the rate of decline and could serve as prognostic markers. Subjects and methods: Audiograms of air conduction thresholds in 69 women with TS (aged 28-62 years) were performed twice with an ave... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013164 Sat, 21 Nov 2009 00:08:03 +0100 3013164 http://www.medworm.com/index.php?rid=3013163&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922095%26dopt%3DAbstract Conclusions: The increased spectral resolution that characterizes the HiRes 120 device contributes to improvement of performance. Discrimination and identification in noise are consistent with reports of improved perception under everyday listening situations. Objectives: This work focuses on speech perception findings after implementation of current steering in HiResolution strategy of children implanted with Clarion HiRes 90K. Subjects and methods: Comparison was made between three groups of children: standard HiRes control group, a second group switched over from HiRes to HiRes 120 and the third group switched on with HiRes 120. Children were tested before and 12 months after implementation of HiRes 120. A standard test battery was administered to obtain a speech perception development ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013163 Sat, 21 Nov 2009 00:08:03 +0100 3013163 http://www.medworm.com/index.php?rid=3013162&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922096%26dopt%3DAbstract Conclusion. High-frequency overstimulation can cause the loss of duration selectivity in low-frequency inferior colliculus neurons in guinea pigs. Objective. To investigate the effect of high-frequency overstimulation on duration tuning in low-frequency inferior colliculus neurons in guinea pigs. Materials and methods. Duration tuning pattern was recorded by measuring the spikes of single neurons in response to the best frequency (BF) of different durations. The effect of high-frequency overstimulation was verified by comparing the responses before and after the tone exposure. Results. In total, 40 duration-tuned neurons were successfully recorded before and after the tone exposure. After the high-frequency tone trauma, a total of 29 neurons (72.5%) became non-duration-tuned. PMID: 199... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013162 Sat, 21 Nov 2009 00:08:03 +0100 3013162 http://www.medworm.com/index.php?rid=3013161&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922097%26dopt%3DAbstract Conclusion. Percutaneous embolization reduces the reappearance of epistaxis and the mean length of hospital stay for patients with intractable epistaxis or juvenile nasopharyngeal angiofibroma (JNA). Objectives. To assess whether percutaneous embolization is effective for the treatment of intractable epistaxis and JNA. Patients and methods. Twenty-eight patients with intractable posterior epistaxis treated by embolization (25 males; m = 59.78 years; SD = 14.3) and 28 unembolized patients (24 males; m = 59.21 years; SD = 15.13) were studied retrospectively. Eight patients with JNA (all males; mean = 16.5 years; SD = 2.35; four embolized before surgery and four unembolized) were also analyzed. Results. Embolization was bilateral in 71.4% of subjects, blood transfusion was required in 28.57%,... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013161 Sat, 21 Nov 2009 00:08:03 +0100 3013161 http://www.medworm.com/index.php?rid=3013160&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922098%26dopt%3DAbstract Conclusion: mometasone furoate nasal spray (MFNS) can reduce the symptoms and improve quality of life in Chinese patients with moderate to severe allergic rhinitis (AR). Objective: To evaluate the effects of MF on symptoms and quality of life in Chinese patients with moderate to severe AR. Patients and methods: In a multicenter and open-label study, 500 patients with moderate to severe AR were enrolled and received MFNS 200 microg once daily. We visited the patients four times (at baseline, and week 1, 2, and 4) to record symptom scores and the influence of AR on daytime activities and quality of sleep. The Mini Rhinoconjunctivitis Quality of Life Questionnaire (Mini-RQLQ) and the Nocturnal Rhinoconjunctivitis Quality of Life Questionnaire (NRQLQ) were used in this study. Results: Compared... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013160 Sat, 21 Nov 2009 00:08:03 +0100 3013160 http://www.medworm.com/index.php?rid=3013159&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922099%26dopt%3DAbstract Conclusion: Radiofrequency (RF) surgery of the upper airways appears to be a safe procedure with an acceptable incidence of minor and moderate complications. Objectives: RF surgery is increasingly used in the treatment of patients with sleep disordered breathing and inferior turbinate hypertrophy. Our aim was to investigate the incidence and the severity of the complications of RF surgery in the upper airways. Patients and methods: This was a retrospective, observational study at a tertiary care centre, academic teaching hospital during 1 year. Data from medical records were collected on 753 consecutive patients treated with RF surgery of the inferior turbinate, soft palate and base of the tongue. Patients with synchronous surgical treatment were excluded. Results: In all, 413 patients (66... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013159 Sat, 21 Nov 2009 00:08:03 +0100 3013159 http://www.medworm.com/index.php?rid=3013158&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922100%26dopt%3DAbstract Conclusion: The narrowing pattern of the upper airway in obstructive sleep apnea patients may be different in sleep as compared with awake. Three different types of obstruction were observed in these subjects during drug-induced sleep. The different obstruction pattern during drug-induced sleep suggests that different strategies should be selected in upper airway management. Objectives: To identify the sites of narrowing and evaluate dynamic upper airway movement in patients with obstructive sleep apnea syndrome (OSAS) while awake and asleep. Patients and methods: This study included 10 patients treated for OSAS between August 2003 and June 2004. Overnight polysomnography was performed on all patients. Parameters including gender, age, neck circumference, and body mass index were recorded.... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013158 Sat, 21 Nov 2009 00:08:03 +0100 3013158 http://www.medworm.com/index.php?rid=3013157&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922101%26dopt%3DAbstract Conclusions: Compared with larynx cancers salvage rates are poorer for hypopharyngeal cancers and the role of primary surgery seems to be significantly higher and more decisive in overall survival (OS). Hypopharyngeal cancers therefore warrant a closer follow-up after an organ preservation protocol, to detect recurrence at the earliest stage and plan for an effective salvage surgery. Objective: To evaluate the survival and morbidity of patients treated by surgery for carcinoma of the larynx and hypopharynx according to site. Patients and methods: All patients who had undergone laryngectomy at the Division of Surgical Oncology Regional Cancer Center (RCC) from June 1995 to December 2005 were included in the study, which retrospectively recorded the age and sex distribution, TNM stage, indic... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013157 Sat, 21 Nov 2009 00:08:03 +0100 3013157 http://www.medworm.com/index.php?rid=3013156&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922102%26dopt%3DAbstract Conclusions: Nerve-muscle pedicle (NMP) implantation was effective in the recovery from atrophic changes in long-term denervated thyroarytenoid (TA) muscle. Re-innervation occurred via the transferred nerve. However, the effectiveness of the NMP method may decline with increasing duration of denervation. Objectives: To evaluate the effects of NMP implantation on long-term denervated rat TA muscle. Materials and methods: Wistar rats (n=105) were divided into two groups in which the left recurrent laryngeal nerve (RLN) was transected without (DNV group) or with (NMP group) subsequent NMP implantation, and subgroups of each group were formed depending on the period after RLN transection (immediate to 48 weeks). In the DNV subgroups, we histologically assessed the area of muscle and the number... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013156 Sat, 21 Nov 2009 00:08:03 +0100 3013156 http://www.medworm.com/index.php?rid=3013155&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922103%26dopt%3DAbstract Conclusion. Endoscope-assisted partial-superficial parotidectomy is a feasible method for treatment of benign parotid superficial lobe tumors located at the anterior or the inferior of the auricular lobule. The main advantage of this procedure is that the small operative scar resulted in improved cosmetic results. Objectives. This study evaluated the feasibility of endoscope-assisted partial parotidectomy through two small skin incisions. Patients and methods. Thirty cases with benign parotid superficial lobe tumors with a diameter < 30 mm located at the anterior or the inferior of the auricular lobule underwent endoscope-assisted partial-superficial parotidectomy via retrograde approach through two small skin incisions. Results. All 30 operations were successfully performed endoscopica... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013155 Sat, 21 Nov 2009 00:08:03 +0100 3013155 http://www.medworm.com/index.php?rid=3013154&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922104%26dopt%3DAbstract Conclusion: Patients showed improved quality of life following tracheal shaving and the carcinoma was well controlled locally, as long as invasion had not progressed to the mucosal surface of the trachea. However, compared with papillary thyroid carcinoma (PTC) with no tracheal invasion, metastasis was common and invasion of organs other than the trachea was frequent, putting many patients into the high-risk group. The clinical course for such patients thus requires careful monitoring, with particular attention to metastasis to other locations. Tracheal shaving can be recommended for patients with PTC with tracheal invasion. Objectives: Macroscopically, in cases where invasion into the trachea has not reached the tracheal mucosa surface, we perform tracheal surface resection (tracheal shav... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013154 Sat, 21 Nov 2009 00:08:03 +0100 3013154 http://www.medworm.com/index.php?rid=3013153&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922105%26dopt%3DAbstract Conclusion: Prognosis was very poor as soon as a local failure developed. Up-front treatment should be optimized to control this rare disease. We propose producing and reporting recommendations via a concerted oncologic physician referral network. PMID: 19922105 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013153 Sat, 21 Nov 2009 00:08:03 +0100 3013153 http://www.medworm.com/index.php?rid=3013152&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922106%26dopt%3DAbstract Conclusion: Calcium alginate (CA) membrane prevents excessive fibrous tissue intrusion and/or dislocation of a bone scaffold. However, CA membrane did not always accelerate cranial bone regeneration. Objective: We previously reported skull regeneration using a bone substitute material (BSM), which consisted of collagen-coated beta-tricalcium phosphate and autologous bone fragments, and bone marrow-derived stromal cells (BSCs). However, excessive fibrous tissue intrusion or dislocation of the BSM occasionally interrupted bone regeneration. To avoid such problems, we examined CA membrane, which is useful for guided bone regeneration (GBR), to investigate whether this material maintains the bone regenerative space. Materials and methods: Bone defects (2x2 cm) were created in the skulls of 12 ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013152 Sat, 21 Nov 2009 00:08:03 +0100 3013152 http://www.medworm.com/index.php?rid=3013151&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922107%26dopt%3DAbstract Conclusion: Changes in tumor necrosis factor-alpha (TNF-alpha) and soluble interleukin-2 (sIL-2R) levels appear to be closely related to tumor progression and prognosis in nasopharyngeal carcinoma (NPC). Further investigation is suggested. Objectives: The study examined whether changes in TNF-alpha and sIL-2R in NPC can be used to predict tumor progression and prognosis. Patients and methods: The study was carried out in 58 patients with NPC newly diagnosed from December 2003 to December 2006 at a single institution and 60 control subjects of comparable age. Blood levels of TNF-alpha and sIL-2R were monitored before, during, and 3 months and 1 year after treatment. Results: Differences in TNF-alpha level between patients with NPC in all four stages and healthy controls and in sIL-2R level ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013151 Sat, 21 Nov 2009 00:08:03 +0100 3013151 http://www.medworm.com/index.php?rid=3013150&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922108%26dopt%3DAbstract Authors: Sekimoto S, Tsunoda K, Kaga K, Makiyama K, Tsunoda A, Kondo K, Yamasoba T We have developed a special purpose adaptor making it possible to use a commercially available high-speed camera to observe vocal fold vibrations during phonation. The camera can capture dynamic digital images at speeds of 600 or 1200 frames per second. The adaptor is equipped with a universal-type attachment and can be used with most endoscopes sold by various manufacturers. Satisfactory images can be obtained with a rigid laryngoscope even with the standard light source. The total weight of the adaptor and camera (including battery) is only 1010 g. The new system comprising the high-speed camera and the new adaptor can be purchased for about $3000 (US), while the least expensive stroboscope costs about... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013150 Sat, 21 Nov 2009 00:08:03 +0100 3013150 http://www.medworm.com/index.php?rid=3013149&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19922109%26dopt%3DAbstract Authors: Ishimoto SI, Tsunoda K, Akiya K, Fujimaki Y, Okada K, Kinoshita M, Yoshida T PMID: 19922109 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3013149 Sat, 21 Nov 2009 00:08:03 +0100 3013149 http://www.medworm.com/index.php?rid=3004754&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19916895%26dopt%3DAbstract Conclusion: The prevalence of self-reported and physician-diagnosed allergic rhinitis (AR) exhibits significant variability across the seven geographical regions in Turkey. Our findings may contribute to the formulation of public health policy and development of preventive and therapeutic strategies for AR in Turkey. Objective: The purpose of this study was to assess the prevalence of AR in the Turkish adult population, with emphasis on descriptive parameters in seven distinct geographical regions in Turkey. Methods: The volunteers were evaluated with a custom-designed questionnaire for AR. Sample size for the study was calculated by allowing for 2% error in prevalence along with a 95% confidence interval (CI). At the end of the study, we reached 4125 volunteers. The data were analyzed wit... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3004754 Tue, 17 Nov 2009 00:00:00 +0100 3004754 http://www.medworm.com/index.php?rid=3004753&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19916896%26dopt%3DAbstract Conclusion: In clinical practice, sudden low-tone loss other than acute low-tone sensorineural hearing loss (ALHL) shows a potential for recurrence. Objective: ALHL is often associated with recurrence and/or progression to Ménière's disease. We examined the prognosis of patients with sudden low-tone loss who were not classified in the audiometric definition of ALHL. Methods: Sixty-three patients diagnosed at the university hospital with idiopathic sudden low-tone loss of sensorineural hearing loss and without subjective vertigo were followed up in the long term with a mean of over 4 years. The rates of recurrence and/or progression to Ménière's disease for patients with low-tone loss type other than ALHL (non-ALHL) were compared with those for ALHL patients. Results: Th... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3004753 Tue, 17 Nov 2009 00:00:00 +0100 3004753 http://www.medworm.com/index.php?rid=3004752&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19916897%26dopt%3DAbstract Conclusion. We developed a new coordinates system for magnetic resonance imaging (MRI) that utilizes the labyrinth and eyeballs as references to measure the spatial arrangement of cranial organs, and we verified its usefulness by observing small structures in the labyrinth in 39 ears from 33 patients. Our new coordinates system could be used for stereotactic analysis of cranial organs in MRI. Objectives. To research semicircular canal anatomy in healthy organisms, we propose a method that employs references visible on MRI for stereotactic measurement of cranial structures, and we evaluated the usefulness of our method. Methods. Using the new coordinates system and vector analysis, we calculated angles among the semicircular canals and sagittal head plane from MRI volume data containing tem... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3004752 Tue, 17 Nov 2009 00:00:00 +0100 3004752 http://www.medworm.com/index.php?rid=3004751&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19916898%26dopt%3DAbstract Conclusion: Among patients with facial nerve paralysis, significant difference was observed on three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI) between those with and without audio-vestibular disturbance. This MRI technique may contribute to elucidation of the pathology of Ramsay Hunt syndrome and Bell's palsy. Objective: To evaluate the 3D-FLAIR MRI findings in patients who have facial nerve paralysis with and without audio-vestibular disturbance. Methods: 3D-FLAIR MRI was performed with and without gadolinium enhancement in 15 patients (5 men and 10 women) with unilateral facial nerve paralysis: 3 patients with Ramsay Hunt syndrome, 3 patients having facial nerve paralysis with hearing loss or vertigo without vesicles, and 9 patients with Be... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3004751 Tue, 17 Nov 2009 00:00:00 +0100 3004751 http://www.medworm.com/index.php?rid=3004750&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19916899%26dopt%3DAbstract We report on a 58-year-old otherwise healthy male patient who presented with acute-onset intermittent dysphagia, mild dyspnea, and chest symptoms. He was referred to an emergency ENT unit for a suspected peritonsillar abscess but died of a massive aortic dissection and cardiac tamponation a few hours later. This rare condition is discussed in the differential diagnosis of adult acute-onset dysphagia. PMID: 19916899 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=3004750 Tue, 17 Nov 2009 00:00:00 +0100 3004750 http://www.medworm.com/index.php?rid=2981477&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895329%26dopt%3DAbstract Conclusion: A developmental histologic study of the otic capsule indicates that it grows a system of lamellar bone with abundant interconnecting intraosseous channels. These include the 'cartilage canals' in the cartilage model, the chondro-osseous and Haversian-like (Volkmann's) canals in the ossified otic capsule, the fissula ante fenestram, which seems to function as a lifelong manufacturer of the latter two channels, and the inner layer (vestibular arch) of the vestibular aqueduct, which is a complex series of Volkmann's canals and microcanals. Chemical changes, possibly produced by breakdown of cells within the channels, may provide a homeostatic environment for the functions of hearing and balance that take place in the endolymphatic fluid. Objectives: We studied the development of t... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2981477 Sat, 07 Nov 2009 00:00:00 +0100 2981477 http://www.medworm.com/index.php?rid=2981476&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895330%26dopt%3DAbstract Conclusion: SOD1 is an important gene related to noise-induced hearing loss (NIHL), and its effect is dependent on noise exposure levels. Objectives: To test whether the polymorphisms in the CuZn-superoxide dismutase gene (SOD1) are associated with susceptibility to NIHL in the Chinese population. Methods: Audiometric data from 2400 Chinese Han people exposed to occupational noise were analyzed. DNA samples were collected from the 10% most susceptible and the 10% most resistant individuals. Four SNPs in the introns of SOD1 were genotyped and their effects and interactions with noise exposure were analyzed. Results: Genotype AA of rs2070424 conferred protection against NIHL (adjusted OR = 0.45, p = 0.005), while GG of rs10432782 was a risk genotype (adjusted OR = 1.88, p = 0.026). One prote... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2981476 Sat, 07 Nov 2009 00:00:00 +0100 2981476 http://www.medworm.com/index.php?rid=2981475&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895331%26dopt%3DAbstract Conclusions: The location and three-dimensional (3D) shapes of the otosclerotic foci suggest a general centripetal distribution of otosclerotic bone remodeling around the inner ear space, whereas the normal bone remodeling is distributed centrifugally. The existence of an inverse spatial relation between normal and otosclerotic bone remodeling suggests that inner ear mechanisms in control of bone remodeling may have a pathogenetic role in otosclerosis. Objectives: To explore the 3D shape of otosclerotic lesions around the inner ear space by introducing the use of 3D reconstructions and to discuss the results in a new context of temporal bone dynamics and perilabyrinthine signaling pathways. Methods: Thirty-four otosclerotic lesions from 20 decalcified human temporal bones were rendered and... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2981475 Sat, 07 Nov 2009 00:00:00 +0100 2981475 http://www.medworm.com/index.php?rid=2981474&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895332%26dopt%3DAbstract Conclusion: This study illustrates that UCP2 Ala55Val polymorphisms exhibit a significant association with age-related hearing loss in the Japanese population. Objectives: Mitochondrial uncoupling proteins (UCPs) have been suggested to play a protective role against neuron oxidative damage and a thermal signaling role in neuron modulation in the inner ear. In the current study, we examined the relationship between gene polymorphisms in UCP1 and UCP2 and hearing impairment (HI) in Japanese elderly. Methods: A total of 1547 subjects aged 40-79 years and living in Aichi prefecture, Japan, were entered into this study. Subjects were followed up every 2 years, and the cumulative number of subjects for 3 sequential examinations in 6 years was 4942 persons. Detailed questionnaires, pure-tone audi... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2981474 Sat, 07 Nov 2009 00:00:00 +0100 2981474 http://www.medworm.com/index.php?rid=2981473&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895333%26dopt%3DAbstract Conclusion: Middle and inner ear interactions in otitis media can lead to cochlear pathology. More severe pathological changes observed in the basal turn of the cochlea are consistent with prevalence of sensorineural hearing loss at higher frequencies in patients with otitis media. Methods: Of 614 temporal bones with otitis media, 47 with chronic and 35 with purulent otitis media were selected following strict exclusion of subjects with a history of acoustic trauma, head trauma, ototoxic drugs, and other diseases affecting the cochlear labyrinth. Temporal bones with labyrinthine inflammatory changes were further evaluated for loss of hair cells and other histopathologic changes compared to age-matched controls. Results: In all, 19% of temporal bones with chronic and 9% with purulent otitis... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2981473 Sat, 07 Nov 2009 00:00:00 +0100 2981473 http://www.medworm.com/index.php?rid=2981472&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895334%26dopt%3DAbstract Conclusions: Provox Vega prostheses demonstrate good short-term feasibility, and their optimized airflow-resistance design offers laryngectomy patients indwelling voice prostheses with more choices in outer diameters without sacrificing (too) much in voice quality. Objectives: Technological progress enables improvement of in vitro airflow characteristics of voice prostheses and design of voice prostheses with smaller outer diameters. This could potentially improve voice quality in users of Provox2, and avoid diminished voice quality in users of prostheses with smaller outer diameters. Methods: This was a prospective clinical phase I/feasibility study of three newly designed indwelling voice prostheses (Provox Vega 22.5 (Provox2 successor), 20, and 17Fr). Assessments consisted of patients' ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2981472 Sat, 07 Nov 2009 00:00:00 +0100 2981472 http://www.medworm.com/index.php?rid=2963807&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19883172%26dopt%3DAbstract Conclusions: Success in conservation of residual hearing after cochlear implantation has benefited patients with high levels of residual low frequency hearing who were not previously considered for conventional cochlear implantation. Technological developments play a key role in minimizing trauma to the cochlea during placement of electrodes. Objectives: The Nucleus(R) Straight Research Array (SRA) has been designed and developed as a collaboration project between our centre and Cochlear Ltd with the objective of minimizing trauma to the cochlea with insertion of the electrode via the round window. Methods: We studied 22 fresh or thawed fresh-frozen human temporal bones implanted by one otosurgeon with the SRA electrode with a standard round window technique used for cochlear implantation.... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2963807 Mon, 02 Nov 2009 00:00:00 +0100 2963807 http://www.medworm.com/index.php?rid=2963806&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19883173%26dopt%3DAbstract Conclusions: Recurrence of vestibular neuritis (VN) is a rare event in long-term follow-up. The incidence of benign paroxysmal positional vertigo (BPPV) in VN patients represents a quite common outcome. To our knowledge, this study represents the only long-term longitudinal study on recurrence of VN and incidence of secondary BPPV in VN. Objectives: To study a large number of VN patients longitudinally to identify the recurrence rate of VN and incidence of BPPV, other peripheral vestibular disorders, sudden hearing loss or Bell's palsy. Methods: This prospective cohort study assessed a VN patient-based clinic population. All patients received a complete bedside clinical examination and caloric irrigation. Results: Long-term (range 4-6 years, mean 4.9 years) longitudinal follow-up examinati... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2963806 Mon, 02 Nov 2009 00:00:00 +0100 2963806 http://www.medworm.com/index.php?rid=2963805&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19883174%26dopt%3DAbstract Conclusion: In this study we found localized malignant lymphomas of the head and neck to be highly treatable and to have a significantly improved prognosis with recent treatment methods. The head and neck surgeon should keep in mind that the prognosis, especially for diffuse large B-cell lymphoma, has improved if the patient receives the optimal treatment. Objectives: The purpose of this study was to ascertain the current prognosis of localized malignant lymphoma of the head and neck given recent advancements in treatment and diagnostic features, as well as adding histological subtypes to the literature according to the 2001 classification. Methods: We present a retrospective study including a cohort of 100 consecutive patients who had localized malignant lymphoma within the head and neck ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2963805 Mon, 02 Nov 2009 00:00:00 +0100 2963805 http://www.medworm.com/index.php?rid=2963804&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19883175%26dopt%3DAbstract Conclusion: Preoperative imaging is important, because of the small size of the cribriform plate, different anatomical variants of the olfactory fossa in varied patients and unequal width of the cribriform plate in the anterior and posterior third. Objective: Digital volume tomography (DVT) is a rather new imaging technique for the diagnosis of diseases of paranasal sinuses. This technology is dedicated to the evaluation of the distinctive structures of the anterior skull base due to the high resolution of the DVT. Based on the Keros classification this anatomic area was analyzed radiologically and also in relation to the uncinate process. Methods: The investigation was performed on 111 patients. The Accu-I-tomo F17 was used. Patients with total nasal polyposis and patients who had undergo... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2963804 Mon, 02 Nov 2009 00:00:00 +0100 2963804 http://www.medworm.com/index.php?rid=2963803&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19883176%26dopt%3DAbstract Conclusion: When combined with vestibular dysfunction, visual flow can exacerbate reductions in postural stability. This effect may be one of the mechanisms underlying visual vertigo, which can be evaluated using frequency analysis of body sway elicited by optokinetic stimulation (OKS). Objective: To clarify the interaction between the postural responses to visual flow and to input from the vestibular apparatus as a mediator of visual vertigo. Methods: Horizontal and vertical OKS with a stable fixation target were presented to 14 healthy subjects and 38 peripheral vestibular patients standing in a Romberg's posture, and the center of standing pressure was monitored using a force platform. The direction and amplitude of induced body sway were analyzed, along with the power spectra of the bo... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2963803 Mon, 02 Nov 2009 00:00:00 +0100 2963803 http://www.medworm.com/index.php?rid=2963802&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19883177%26dopt%3DAbstract Conclusions: Indirect computed tomography lymphography (CT-LG) combined with blue dye injection can locate the sentinel lymph node (SLN) in tongue carcinoma. Objective: To localize the SLN in tongue VX2 carcinoma using indirect CT-LG combined with methylene blue injection. Methods: Eighteen rabbits were placed into three groups: metastasis, hyperplasia, and control. Indirect CT-LG was performed with an iohexol injection into the tongue submucosa. CT images were acquired at 1, 5, and 15 min after injection. Methylene blue was injected into the same area 24 h after indirect CT-LG, followed by SLN identification and histopathological examination. Results: SLNs were visualized with an identification rate of 100%. SLN location identified using CT lymphography was confirmed by methylene blue dye... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2963802 Mon, 02 Nov 2009 00:00:00 +0100 2963802 http://www.medworm.com/index.php?rid=2963801&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19883178%26dopt%3DAbstract We report a case of vestibular schwannoma with absent vestibular evoked myogenic potentials (VEMPs) to clicks but normal auditory brainstem responses, caloric responses, and vestibular evoked myogenic potentials to 500 Hz tone bursts. This patient visited our clinic with complaint of sudden right hearing loss. This was the third episode of hearing loss in his right ear. Due to atypical medical history, he underwent further neuro-otological and neuroradiological examinations. Among the neurophysiological tests, only VEMPs to clicks showed abnormal findings (absent responses on the right). MRI revealed a small vestibular schwannoma in the right internal auditory meatus, which was considered to be of inferior vestibular nerve origin. This case suggested that VEMPs to clicks should still be in... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2963801 Mon, 02 Nov 2009 00:00:00 +0100 2963801 http://www.medworm.com/index.php?rid=2963800&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19883179%26dopt%3DAbstract Conclusion: The modified septoplasty with three tension lines resection is an effective and well-tolerated procedure, which can improve the objective and subjective outcomes, and provide a good approach that is applicable for various septal deviations, especially caudal deviation. Objectives: According to the biomechanics of the septal deviation, a modified septoplasty with three high tension lines resection was redefined. The purpose of this study was to review the surgical technique and objective and subjective outcomes. Methods: A retrospective review was conducted to identify patients undergoing septoplasty between 2005 and 2006 at Beijing Tongren Hospital. The records were reviewed for demographic data, intraoperative technique, surgical indications, objective and subjective outcomes,... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2963800 Mon, 02 Nov 2009 00:00:00 +0100 2963800 http://www.medworm.com/index.php?rid=2963799&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19883180%26dopt%3DAbstract Conclusion: Cochlear implantation assessment is possible using commercially available standard flat-detector computed tomography (FD-CT) protocols. Image quality is superior to multislice CT (MSCT). The radiation dose of FD-CT is lower in comparison with MSCT standard protocols and may therefore overcome the limitations of MSCT in the evaluation of cochlear implants. PMID: 19883180 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2963799 Mon, 02 Nov 2009 00:00:00 +0100 2963799 http://www.medworm.com/index.php?rid=2963798&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19883181%26dopt%3DAbstract Conclusion: The administration of cisplatin induces the activation of superoxide dismutase (SOD) as a response to oxidative stress in the cochleae of Sprague-Dawley rats and this activation is proportional to the activation of the intrinsic pathway of apoptosis. Objectives: To determine the role of the antioxidant endogenous mechanism in the preservation of cochlear integrity and function in an experimental model of cisplatin ototoxicity. Methods: Sixteen Sprague-Dawley rats were studied at 7 days after intraperitoneal injection of CDDP (n = 8) or 10 ml/kg NaCl 0.9% w/v in the control group (n = 8) by means of auditory steady-state responses. These findings were compared with the expression of SOD and caspase-3/7 and caspase-9 activities. Results: Groups receiving cisplatin showed increase... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2963798 Mon, 02 Nov 2009 00:00:00 +0100 2963798 http://www.medworm.com/index.php?rid=2963797&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19883182%26dopt%3DAbstract Conclusions: Laryngeal moderately differentiated neuroendocrine carcinoma (LMDNEC) is an aggressive and uncommon malignancy. Thorough histological evaluation is the key to correct diagnosis and differentiation. Complete surgical resection of laryngeal primary lesions and suitable neck dissection of cervical nodes provide reasonable therapy, and postoperative radiotherapy should also be considered. Objective: To explore the diagnosis and treatment of LMDNEC. Methods: Clinical information regarding patient, presentation, immunohistochemical results, treatment, and outcome was obtained through review of patients' charts. Follow-up until the time of death or last contact with us was obtained for all patients. Results: Eight patients (six males, two females) were pathologically confirmed to hav... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2963797 Mon, 02 Nov 2009 00:00:00 +0100 2963797 http://www.medworm.com/index.php?rid=2946154&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863302%26dopt%3DAbstract CONCLUSIONS: Results of audiometry, caloric testing and vestibular evoked myogenic potential (VEMP) testing were hardly influenced by plugging surgery. OBJECTIVE: To evaluate the influence of surgical plugging of the posterior semicircular canal on inner ear function in patients with benign paroxysmal positional vertigo (BPPV). SUBJECTS AND METHODS: The subjects were five consecutive patients with intractable BPPV who underwent plugging surgery. The following functions of the inner ear were examined before and 6 months after surgery. Cochlea function was evaluated by the average hearing level of three frequencies (500, 1000 and 2000 Hz), that of the semicircular canal by canal paresis percent (CP%) in caloric testing and that of the otolith by the left-right difference ratio on VEMP testin... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946154 Sat, 31 Oct 2009 15:23:35 +0100 2946154 http://www.medworm.com/index.php?rid=2946142&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863303%26dopt%3DAbstract CONCLUSION: An animal model of cochlear implantation with a local intracochlear fluid through a microcatheter included in the array has been developed. It is suitable for evaluation of putative therapeutic agents to decrease cochlear trauma after cochlear implantation. OBJECTIVES: The purpose of this study was to design an animal model of cochlear implantation with an intracochlear fluid delivery system to demonstrate the stability of the device and study the patterns of hearing loss. MATERIALS AND METHODS: Eleven guinea pigs were implanted with a prototype array that comprised one electrode and a microcatheter connected to an osmotic minipump containing saline serum. Three animals were implanted with the same electrode carrier without any connection to the minipump. Preoperative and posto... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946142 Sat, 31 Oct 2009 15:23:32 +0100 2946142 http://www.medworm.com/index.php?rid=2946141&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863304%26dopt%3DAbstract CONCLUSION: Because of the lack of association between a positive test and response to corticosteroid treatment, at present, detection of anti-HSP 70 antibody, tumor necrosis factor (TNF)-alpha, erythrocyte sedimentation rate (ESR), or antinuclear antibody (ANA), does not offer clinically useful information in the treatment of Meniere's disease (MD). OBJECTIVES: The study was designed to investigate the performance of various laboratory tests, including anti-HSP 70, TNF-alpha, ESR, ANA, and anti-phospholipid antibodies, in the diagnosis and treatment response of patients with MD. PATIENTS AND METHODS: Thirty patients who presented with MD and 30 healthy people were selected as study and control groups, respectively. The laboratory panel included the following tests: anti-HSP 70 antibody im... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946141 Sat, 31 Oct 2009 15:23:30 +0100 2946141 http://www.medworm.com/index.php?rid=2946140&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863305%26dopt%3DAbstract CONCLUSION: The rendering strategy sometimes induces misunderstanding of the image. We demonstrated a more accurate image of the bony groove of the reuniting duct using three-dimensional (3D) cone beam CT image, which was less affected by artifacts created by the rendering effect. OBJECTIVE: To obtain a suitable image of the groove of the reuniting duct for future morphological study. MATERIALS AND METHODS: The grooves of reuniting ducts in 10 healthy human subjects were analyzed by cone beam CT in comparison with a cadaver study. RESULTS: We could obtain more accurate 3D CT images of the bony groove in human subjects by checking the landmarks of 3D CT images. PMID: 19863305 [PubMed - in process] (Source: Acta Oto-Laryngologica) Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946140 Sat, 31 Oct 2009 15:23:25 +0100 2946140 http://www.medworm.com/index.php?rid=2946139&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863306%26dopt%3DAbstract CONCLUSION: Magnetic resonance imaging (MRI) after intratympanic gadolinium injection can reveal endolymphatic hydrops (ELH) in patients with delayed ELH (DELH). Patients with contralateral DELH may have bilateral ELH. OBJECTIVE: DELH has previously been diagnosed based on clinical history, hearing and vestibular examinations. DELH is classified into three types: ipsilateral, contralateral and bilateral indicate the side with the longstanding hearing loss. Ipsilateral DELH occurs in the ear with a profound hearing loss, contralateral DELH in the better hearing ear and bilateral DELH in both ears. Imaging diagnosis of the endolymphatic space may add a new dimension to the diagnosis and treatment of DELH. PATIENTS AND METHODS: Gadodiamide hydrate was diluted eightfold with saline. The dilute... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946139 Sat, 31 Oct 2009 15:23:21 +0100 2946139 http://www.medworm.com/index.php?rid=2946138&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863307%26dopt%3DAbstract CONCLUSION: ERalpha and ERbeta are present in the inner ear and are up- and down-regulated depending on the stage of maturation, development and pregnancy, suggesting that estrogen may have an effect on the cochlea during various stages of life. No estrogen receptors (ERs) were found in the cochlea of the developing fetus, which suggests that estrogen does not have an effect on the cochlea during gestation. OBJECTIVE: To investigate the distribution of ERs in the cochlea during pregnancy, maturation and development in a female rat model. MATERIALS AND METHODS: The cochleas of 24 rats in 4 groups in different time periods of maturation (21 and 56 days old) and pregnancy (day 8 and 18 of pregnancy) and 16 fetuses at gestational ages of 8 and 18 days were collected. All specimens were stained... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946138 Sat, 31 Oct 2009 15:23:19 +0100 2946138 http://www.medworm.com/index.php?rid=2946137&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863308%26dopt%3DAbstract CONCLUSION: By means of a direct, though non-invasive experiment on healthy humans we could demonstrate that middle ear (ME) pressure decreases when the eustachian tube (ET) does not open. Thus with a very simple method the basic theory of continuous gas loss from the ME into the circulation and the replenishment of the loss through the ET could be validated. OBJECTIVES: To record changes in ME pressure over a period of time in normal human ears, while the ET is kept closed. SUBJECTS AND METHODS: On-line tympanometry was carried out in three subjects, who refrained from swallowing for 20-120 min. RESULTS: During the time when the ET was kept closed by refraining from swallowing, tympanometric monotonous pressure decrease was recorded. Once the tested subject could not refrain from swallowi... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946137 Sat, 31 Oct 2009 15:23:16 +0100 2946137 http://www.medworm.com/index.php?rid=2946136&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863309%26dopt%3DAbstract CONCLUSION: Depletion of enzymatic antioxidants was observed in cholesteatoma. However, a relationship between activity of enzymatic antioxidants and the extent of bone erosion was not found. OBJECTIVES: To measure the level of major enzymatic antioxidants in cholesteatoma, and to investigate the relationship between the level of enzymatic antioxidants and the extent of bone erosion. PATIENTS AND METHODS: The cholesteatoma and skin samples were obtained during otologic surgeries. All cases were grouped according to the number of bone erosion sites. Samples were examined biochemically and the levels of enzymatic antioxidants were measured. The results were analyzed statistically. RESULTS: Thirteen patients were included in the study. The mean level of superoxide dismutase in cholesteatoma a... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946136 Sat, 31 Oct 2009 15:23:13 +0100 2946136 http://www.medworm.com/index.php?rid=2946135&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863310%26dopt%3DAbstract CONCLUSIONS: This study showed that macrophages, B cells, and T cells occurred at different frequencies, localizations, and times after acute laser tympanic membrane perforation. Immunological cells were most prevalent in the proliferative mass adjacent to the annulus region. The cellular immunological response in freshly perforated eardrums was unexpectedly aggressive. OBJECTIVES: To study the occurrence of immunocompetent cells during the healing process of fresh perforated tympanic membranes. The information could be used to develop alternative outpatient procedures in the cure of chronic perforations, replacing conventional surgery. MATERIALS AND METHODS: A laser myringotomy was carried out in Sprague-Dawley rats, which were sacrificed at 3 and 6 days after the myringotomy. Tympanic me... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946135 Sat, 31 Oct 2009 15:23:10 +0100 2946135 http://www.medworm.com/index.php?rid=2946134&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863311%26dopt%3DAbstract CONCLUSIONS: Our results show that among the patients with inner ear malformations, there were two patients with sensory cells of sacculus and inferior vestibular neurons and at least five patients with inferior vestibular neurons only, but no patients without sensory cells and vestibular neurons, as determined on the basis of vestibular evoked myogenic potentials (VEMPs). OBJECTIVE: The aim of this study was to investigate whether sensory cells of sacculus or inferior vestibular neurons or both are present in cochlear implant patients with inner ear malformations, particularly common cavity (CC) deformity, using VEMPs. PATIENTS AND METHODS: Seven children with inner ear malformation who underwent cochlear implantation (CI) participated in this study. The patients had CC deformity (n=2), i... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946134 Sat, 31 Oct 2009 15:23:08 +0100 2946134 http://www.medworm.com/index.php?rid=2946133&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863312%26dopt%3DAbstract CONCLUSION: The pathology of chronic otitis media (COM) could delay and reduce the energy transfer of sound to the inner ear. The significant improvement of postoperative vestibular evoked myogenic potential (VEMP) response rate and p13 latencies in the group of patients with no or negative postoperative ABG gain provided evidence that the sound energy inducing a VEMP might be different from the energy producing the auditory perception. OBJECTIVE: To evaluate the VEMP in patients with COM before and after surgery. SUBJECTS AND METHODS: Twenty-four subjects with unilateral COM were enrolled. A pure tone audiogram and VEMP using 500 Hz unilateral short tone-burst stimulations were recorded before and 3 months after surgery. The postoperative VEMP responses were compared with the responses be... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946133 Sat, 31 Oct 2009 15:23:04 +0100 2946133 http://www.medworm.com/index.php?rid=2946132&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863313%26dopt%3DAbstract CONCLUSION: Both mitomycin C (MC) and 5-fluorouracil (5-FU) had a significant effect in prolonging the patency rate of radiofrequency myringotomy. OBJECTIVE: To compare the effect of topical use of MC and 5-FU on the closure time of myringotomies created by a radiofrequency unit. MATERIALS AND METHODS: Myringotomies were performed using a radiofrequency unit on 80 tympanic membranes of 40 rats. Rats were divided into two study groups and one control group. MC (0.4 mg/ml) and 5-FU (50 mg/ml) pledgets were applied topically in the right ears (study groups, 20 ears each) for 10 min and saline pledgets in the left ears (control group, 40 ears). Animals were monitored using otomicroscopy weekly and patency rates were recorded until myringotomy closure. RESULTS: The mean patency times were 4.85 ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946132 Sat, 31 Oct 2009 15:23:02 +0100 2946132 http://www.medworm.com/index.php?rid=2946131&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863314%26dopt%3DAbstract CONCLUSIONS: After forced prolonged position type one (FPP-one) and the appropriate repositioning maneuvers, or FPP-two, 95.45% of patients with cupulolithiasis of the horizontal semicircular canal benign paroxysmal positional vertigo (HSC-BPPV).were symptom-free. OBJECTIVES: To treat patients with cupulolithiasis of the HSC-BPPV. SUBJECTS AND METHODS: This was a prospective study including 22 subjects with HSC-BPPV (cupulolithiasis) based on apogeotropic direction-changing positional nystagmus (apo-DCPN). Patients adopted FPP-one, which means lying down on the side of the weaker nystagmus during nightly rest for 2 weeks. If apo-DCPN persisted, subjects adopted type two FPP (FPP-two), which means lying on the strongest nystagmus side during nightly rest for 2 weeks. RESULTS: No vertigo or ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946131 Sat, 31 Oct 2009 15:22:59 +0100 2946131 http://www.medworm.com/index.php?rid=2946130&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863315%26dopt%3DAbstract CONCLUSION: The longer alleles (CA)17-20 of the promoter region of PARP-1 gene may confer some protection against bilateral Meniere's disease (BMD). OBJECTIVE: To analyze microsatellite (CA)(n) polymorphisms in the promoter region of PARP-1 gene and seek out risk and protective variants for BMD. SUBJECTS AND METHODS: Eighty patients from two ethnically defined groups with definite BMD, according to the diagnostic scale of the American Academy of Otolaryngology Head and Neck Surgery, were compared with a group of 371 normal controls from the same origin in a prospective multicenter study. We developed a specific amplification protocol to determine the PARP1-promotor CA microsatellite polymorphisms. RESULTS: We found that the longer alleles (CA)17-20 had a very low frequency in BMD (2/160, 1... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946130 Sat, 31 Oct 2009 15:22:57 +0100 2946130 http://www.medworm.com/index.php?rid=2946129&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863316%26dopt%3DAbstract CONCLUSIONS: The caloric test with head-tilt can be used as a tool for assessing vertical canal function as an office procedure. OBJECTIVE: Evaluation of vertical canal function. PATIENTS AND METHODS: We provoked caloric response by cold water in the vertiginous patients in supine position. During the culmination of the response we rotated the head 45 degrees from the sagittal plane to place the posterior canal to earth-vertical. Thereafter we rotated the head 45 degrees to the opposite direction to place the anterior canal to earth-vertical. The eye movements were recorded by two-dimensional electronystagmography. The data collected from the examination of 100 ears with normal caloric response in horizontal component were analyzed. RESULTS: The down-beating vertical component intensified ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946129 Sat, 31 Oct 2009 15:22:54 +0100 2946129 http://www.medworm.com/index.php?rid=2946128&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863317%26dopt%3DAbstract CONCLUSION: Subjects with self-reported nasal symptoms following consumption of red wine may respond with less nasal blockage to a wine produced with ecological methods than to wine not labelled as ecologically produced. OBJECTIVE: To compare nasal symptoms following intake of three different wines--one that was ecologically produced and two that were traditionally produced. SUBJECTS AND METHODS: Individuals with self-reported nasal symptoms following consumption of red wine were subjected to controlled intake of three different wines in a double-blinded, randomized, and crossover design. Nasal symptoms and peak nasal inspiratory flow (PNIF) were monitored before and 15, 30, 45, and 60 min following intake of wine. RESULTS: All wines produced nasal symptoms, notably nasal blockage. While b... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946128 Sat, 31 Oct 2009 15:22:51 +0100 2946128 http://www.medworm.com/index.php?rid=2946127&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863318%26dopt%3DAbstract CONCLUSION: The mucosa compliance in lesions is determined by the congestion index, enabling us to determine whether the patient is sensitive to pharmacotherapy and to choose surgical management rationally. OBJECTIVE: To explore the correlation between the nasal mucosa congestion index and tissue remodeling in chronic rhinosinusitis (CRS) and to provide objective evidence for clinical choice of therapeutic methods. PATIENTS AND METHODS: Forty-four patients with CRS who underwent nasal endoscopic surgery were enrolled in the study. The congestion indexes of the nasal mucosa were measured using an acoustic rhinometer and specimens were taken from the uncinate process mucosa to evaluate vascular density and degree of fibrosis. The correlations were statistically analyzed. RESULTS: There was a... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946127 Sat, 31 Oct 2009 15:22:48 +0100 2946127 http://www.medworm.com/index.php?rid=2946126&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863319%26dopt%3DAbstract CONCLUSIONS: Human papilloma virus (HPV) was associated with sinonasal inverted papilloma (SIP) in 14/20 (70%) patients with a prevalence of HPV 6/11; alterations of the cell cycle proteins were statistically significant. OBJECTIVES: We investigated SIPs relationships between HPV infection and aberrant expression of cell cycle proteins. MATERIALS AND METHODS: Twenty SIPs were evaluated for p53, p16(INK4a), pRb, p21(WAF1), p27(Kip1), cyclin D1 and Ki-67 expression by immunohistochemistry. HPV was investigated by polymerase chain reaction (PCR). RESULTS: HPV DNA was detected in 14/20 patients with inverted papillomas (IPs) (70%). The majority of tumours showed strong p16, p21, p27, pRb and cyclin D1 staining and little or no p53 expression. Tumours harbouring dysplasia were significantly mor... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946126 Sat, 31 Oct 2009 15:22:45 +0100 2946126 http://www.medworm.com/index.php?rid=2946098&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863320%26dopt%3DAbstract CONCLUSION: Chemosensory event-related potentials (CSERPs) were identified in all measurements using the 20 s and the 10 s inter-stimulus interval (ISI) protocol, reducing the recording time to 75% or 57% compared with the standard protocol. A possible explanation for the rising CSERP amplitudes by shortening the ISI in CO(2) stimulation is due to a phenomenon known as trigeminal sensitization during repeated stimulation. OBJECTIVES: CSERPs are influenced by the ISI. The aim of this study was to evaluate the changes in CSERPs by decreasing the ISI from 30 s to 20 s or 10 s, respectively. SUBJECTS AND METHODS: Ten normosmic healthy subjects participated this study. Phenyl ethyl alcohol (PEA), hydrogen sulphide (H(2)S) and carbon dioxide (CO(2)) were used in CSERP measurements with different... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946098 Sat, 31 Oct 2009 15:22:42 +0100 2946098 http://www.medworm.com/index.php?rid=2946097&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863321%26dopt%3DAbstract CONCLUSION: This study revealed that the nasal topical drops, which could be purchased without a proper prescription, should not be used randomly and non-selectively. OBJECTIVE: To investigate the effect of nasal drops and sprays on the nasal air flow and mucociliary transport time (MTT) in healthy volunteers with no septal deviation and no history of frequent upper respiratory infection. SUBJECTS AND METHods: Saline, fluticasone propionate drops and sprays, mometasone furoate, budesonide, xylometasoline chloride, fusafungine spray, Ringer's lactate and sea water were selected as the agents to be investigated. Volunteers were subdivided into two subgroups according to their rhinomanometric scores: group 1 consisted of subjects with nasal respiration > or =500 ml at 150 daPa and group 2 ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946097 Sat, 31 Oct 2009 15:22:40 +0100 2946097 http://www.medworm.com/index.php?rid=2946096&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863322%26dopt%3DAbstract CONCLUSION: This study demonstrates morphological changes in the nasal mucosa as a consequence of functional changes of the nasal cavity after total laryngectomy (TLE). OBJECTIVE: Observation of the changes of the nasal mucosa in patients after TLE. PATIENTS AND METHODS: A cohort observational study contained 30 patients after TLE. These patients underwent nasal endoscopy and cytological and microbiological examination of the nasal mucosa. The control group comprised 30 patients. RESULTS: In patients who underwent TLE, morphological changes occurred in the nasal mucosa. The hyperplasia of the cells in the basal zone was the most remarkable change after TLE. The difference was statistically significant (p=0.0002) in comparison with the control group. No statistically significant difference ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946096 Sat, 31 Oct 2009 15:22:37 +0100 2946096 http://www.medworm.com/index.php?rid=2946095&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863323%26dopt%3DAbstract CONCLUSIONS: Patients with mild obstructive sleep apnoea (OSA) depict the disease as being detrimental to their health, causing significant symptoms. These patients were found to achieve significant improvements in OSA-related symptoms after surgical intervention. OBJECTIVES: Although the effects of surgical treatment on OSA have been encouraging in many previous studies, little is known about its effects in patients with mild OSA. The aim of our study was to assess the evolution of symptoms experienced by mild OSA patients after surgical intervention. SUBJECTS AND METHODS: This was an observational follow-up study in a university hospital in Finland. The change in daytime and night-time symptoms was assessed by a standardized questionnaire before treatment and after a mean follow-up time ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946095 Sat, 31 Oct 2009 15:22:35 +0100 2946095 http://www.medworm.com/index.php?rid=2946094&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863324%26dopt%3DAbstract CONCLUSION: Retropharyngeal abscess (RPA) is a rare, potentially life-threatening disease, requiring appropriate otorhinolaryngologic as well as radiologic diagnostics, and medical and surgical intervention by a transoral, transcervical or transnasal approach in a multidisciplinary setting. OBJECTIVES: The risks and benefits of surgical intervention in patients with RPA were assessed. The main outcome measure was the clinical resolution of the abscess. PATIENTS AND METHODS: A retrospective chart review was performed at a tertiary care university hospital over a period of 28 months. Eleven patients aged 1 to 68 years with the diagnosis of RPA were included. RESULTS: All patients presented with restricted cervical mobility and all patients had CT and/or MRI scan on admission. The mean absces... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946094 Sat, 31 Oct 2009 15:22:32 +0100 2946094 http://www.medworm.com/index.php?rid=2946093&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863325%26dopt%3DAbstract CONCLUSIONS: Uvulopalatopharyngoplasty (UPPP) in patients with obstructive sleep apnoea syndrome (OSAS) who had failed treatment with continuous positive airway pressure (CPAP) and mandibular retaining device (MRD) was effective and safe. The satisfaction rate was high. We recommend UPPP in selected OSAS patients, especially younger patients. OBJECTIVES: To evaluate the efficacy and complication rate of UPPP. PATIENTS AND METHODS: This was a non-randomized prospective study of 139 men and 19 women, median age 45 years (range 20-75), median body mass index (BMI) 29 (range 20-48), who underwent UPPP. One year follow-up comprised ambulant sleep apnoea recordings and questionnaires with the Epworth Sleepiness Scale (ESS). RESULTS: In all, 76% of the patients underwent sleep recordings preopera... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946093 Sat, 31 Oct 2009 15:22:29 +0100 2946093 http://www.medworm.com/index.php?rid=2946092&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863326%26dopt%3DAbstract CONCLUSION: The factors responsible for the observed failures can be broken into two major groups: (1) a wrong indication and (2) an inadequate technique to achieve relief from an excessively tight glottal closure. The use of a titanium bridge in place of a silicone shim was found to be essential. Type II thyroplasty can relieve the symptoms of adductor spasmodic dysphonia (AdSD) when implemented with a modern technique using titanium bridges. OBJECTIVES: To identify the factor or factors that necessitated revision surgery in type II thyroplasty for AdSD, detailed analytical examinations were made of individual cases with unsatisfactory outcomes. PATIENTS AND METHODS: A retrospective analysis of a case series with follow-up periods of 2-5 years. RESULTS: Ninety AdSD patients underwent type... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946092 Sat, 31 Oct 2009 15:22:27 +0100 2946092 http://www.medworm.com/index.php?rid=2946091&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863327%26dopt%3DAbstract CONCLUSIONS: Weekly paclitaxel may be an active and well tolerated chemotherapy regimen for patients with platin-resistant advanced head and neck cancer. OBJECTIVES: Weekly paclitaxel should be an active and well tolerated regimen for palliative treatment of platin-resistant patients with recurrent or metastatic carcinoma of the head and neck. We analyzed the antitumor activity and toxicity profile. PATIENTS AND METHODS: Sixty consecutive patients with advanced head and neck cancer were treated with 1 h infusion of paclitaxel, 80 mg/m(2) weekly, for 6 consecutive weeks. Patients who showed disease response or disease stabilization continued until progression of disease. RESULTS: A total of 719 doses of paclitaxel were administered to the 60 patients. No complete response was observed. Part... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946091 Sat, 31 Oct 2009 15:22:24 +0100 2946091 http://www.medworm.com/index.php?rid=2946090&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863328%26dopt%3DAbstract CONCLUSIONS: The prevalence of sleep apnoea among patients following treatment of head and neck carcinomas seems to be slightly higher than in the normal population. The possible importance of tumour treatment features, especially transient tracheostoma, needs further assessment. OBJECTIVES: The epidemiology of sleep apnoea in patients following the treatment of head and neck cancer remains unclear. This study was undertaken to assess the prevalence of sleep apnoea in head and neck cancer patients by characterizing their clinical, anatomical and tumour treatment features. PATIENTS AND METHODS: Our study examined 31 patients in a prospective non-controlled study using a standardized questionnaire that included the Epworth Sleepiness Scale (ESS) and a polygraph. RESULTS: Six of the 31 patien... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946090 Sat, 31 Oct 2009 15:22:22 +0100 2946090 http://www.medworm.com/index.php?rid=2946088&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863329%26dopt%3DAbstract CONCLUSION: The 78th single nucleotide polymorphism (SNP) in exon 20 of epidermal growth factor receptor (EGFR) might be a predictor of the clinical course of squamous cell carcinoma of the head and neck (SCCHN), and genetic predisposition could influence the progression of SCCHN in Chinese subjects. OBJECTIVE: To analyze the clinical significance of EGFR SNP in Chinese SCCHN patients. MATERIALS AND METHODS: Direct sequencing of exons 18-21 was used to analyze somatic mutations of EGFR. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to evaluate the expression level of EGFR. The chi-square test and Kaplan-Meier method were the main statistical methods used to analyze the correlation of the investigated variables and prognostic significance. RESULTS: In analyzing exons 18-... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946088 Sat, 31 Oct 2009 15:22:19 +0100 2946088 http://www.medworm.com/index.php?rid=2946087&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863330%26dopt%3DAbstract CONCLUSION: Extensive bone erosion correlated with a worse prognosis of the squamous cell carcinoma (SCC) of the temporal bone but extensive soft tissue involvement did not correlate with prognosis in this study. Resectability of the tumor seems to be major prognostic factor of temporal bone SCC. OBJECTIVE: Prognostic factors for SCC of the temporal bone were evaluated regarding initial clinical symptoms and radiographic imaging. PATIENTS AND METHODS: Clinical symptoms of the patients with primary SCC of the external auditory canal (EAC) or middle ear (ME) were reviewed based on medical records. Correlation of clinical symptoms and cancer severity staging using the modified Pittsburgh classification was analyzed, along with disease-specific survival (DSS). RESULTS: Sixteen patients with pr... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946087 Sat, 31 Oct 2009 15:22:15 +0100 2946087 http://www.medworm.com/index.php?rid=2946086&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863331%26dopt%3DAbstract CONCLUSIONS: Malignant carotid body tumour (MCBT) is a clinically rare disease that often invades the carotid artery and cranial nerves. Diagnosis of malignant tumour should be based on extensive invasion of neighbouring organs and distant metastasis. Extensive resection should be undertaken early. Radiotherapy is effective, whereas chemotherapy is uncertain. OBJECTIVE: To summarize the clinical pathological and prognostic characteristics of MCBT and explore methods for diagnosis and treatment. MATERIALS AND METHODS: The study material comprised clinical, pathological, therapeutic and follow-up data concerning nine patients (four males, five females) with MCBT, treated at Tianjin Cancer Hospital between January 1956 and June 2006. The material was analysed retrospectively. Disease duration... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946086 Sat, 31 Oct 2009 15:22:12 +0100 2946086 http://www.medworm.com/index.php?rid=2946085&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863332%26dopt%3DAbstract Authors: Miyagawa M, Fukuoka H, Tsukada K, Oguchi T, Takumi Y, Sugiura M, Ueda H, Kadoya M, Usami S A 53-year-old male with fluctuating low frequency sensorineural hearing loss and tinnitus, but without vertigo, was evaluated by MRI obtained by intratympanic injection of a gadolinium-based contrast agent (GBCA) before and after the administration of isosorbide. The endolymphatic hydrops was semi-quantitatively evaluated by a 3.0-T MR scanner. For quantification, the affected side/contralateral side ratios were calculated. A gadodiamide (a kind of GBCA)-enhanced space surrounding the endolymph in the affected side with a 0.50 ratio (which may have represented endolymphatic hydrops) improved after isosorbide therapy to a 0.98 ratio. Thus, endolymphatic hydrops was demonstrated in a patie... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946085 Sat, 31 Oct 2009 15:22:09 +0100 2946085 http://www.medworm.com/index.php?rid=2946084&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19863333%26dopt%3DAbstract CONCLUSION: The study shows that there are differences in the measurement of the action potentials with and without the stylet in the Nucleus Freedom Contour Advance that are higher in the apex than in the base of the cochlea. OBJECTIVES: To determine if there are differences in the intraoperative impedances and in the neural response telemetry threshold values in the Nucleus Freedom Contour Advance before and after stylet removal. SUBJECTS AND METHODS: This was a prospective clinical study. Intraoperative impedances and neural response telemetry in users of the Freedom Contour Advance Cochlear Implant were measured before and after stylet removal. RESULTS: There was a significant reduction in the impedance values of an average 1.5 kOmega+/-2.3 in common ground mode and 1.3 kOmega+/-2.3 fo... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2946084 Sat, 31 Oct 2009 15:22:06 +0100 2946084 http://www.medworm.com/index.php?rid=2921087&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19845490%26dopt%3DAbstract Conclusions: The midfacial degloving approach is a favorable option for advanced sinonasal inverted papilloma with a fair recurrence rate, and can replace the lateral rhinotomy approach, which is considered too invasive for benign tumor due to its facial scar. Objective: This study aimed to assess the treatment outcomes of advanced sinonasal inverted papillomas according to surgical approaches over a 20-year period. Material and methods: We retrospectively reviewed clinic, operative, radiologic, and pathologic records of patients with surgically treated sinonasal inverted papilloma, and compared recurrence rates of patients treated with the endoscopic approach, midfacial degloving approach, and lateral rhinotomy approach in each Krouse stage of inverted papilloma. Results: A total of 114 p... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2921087 Wed, 21 Oct 2009 23:00:00 +0100 2921087 http://www.medworm.com/index.php?rid=2921086&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19845491%26dopt%3DAbstract Conclusion: This paper reviews psychoacoustical and electrophysiological evidence for reorganization of the human central auditory system in case of auditory deprivation and rehabilitation. Objective: To investigate the plasticity of cortical tonotopic maps in cochlear-damaged subjects. Methods: Frequency discrimination scores were analysed in subjects with high frequency hearing loss to test for potential perceptual correlates of auditory deprivation- and rehabilitation-induced plasticity. In cochlear implant patients, electrically evoked auditory cortical responses were obtained using EEG to study scalp potential maps. Results: Perceptual changes in frequency discrimination were observed at the lesion-edge frequency of steeply sloping hearing loss. Although these results are not direct p... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2921086 Wed, 21 Oct 2009 23:00:00 +0100 2921086 http://www.medworm.com/index.php?rid=2801168&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19750397%26dopt%3DAbstract Conclusion: Calcium alginate (CA) membrane prevents excessive fibrous tissue intrusion and/or dislocation of a bone scaffold. However, CA membrane did not always accelerate cranial bone regeneration. Objective: We previously reported skull regeneration using a bone substitute material (BSM), which consisted of collagen-coated beta-tricalcium phosphate and autologous bone fragments, and bone marrow-derived stromal cells (BSCs). However, excessive fibrous tissue intrusion or dislocation of the BSM occasionally interrupted bone regeneration. To avoid such problems, we examined CA membrane, which is useful for guided bone regeneration (GBR), to investigate whether this material maintains the bone regenerative space. Materials and methods: Bone defects (2x2 cm) were created in the skulls of 12 ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2801168 Thu, 10 Sep 2009 23:00:00 +0100 2801168 http://www.medworm.com/index.php?rid=2778831&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19735001%26dopt%3DAbstract Conclusions: Mouse cochleae are highly resistant to systemicallyadministered cisplatin. However, cochlear lesions can be produced effectively in mice when cisplatin is applied locally through the round window niche or tympanum. Objective: To explore the optimal approach for creating cisplatin-induced cochlear lesions in mice. Materials and methods: Cisplatin was administered to adult C57BL/6J mice via four approaches: (1) transtympanic injection, (2) round window niche injection, (3) intraperitoneal injection (i.p.) at 4 mg/kg/day for 4 consecutive days, and (4) one 15 mg/kg dose i.p. The hearing was monitored using frequency-specific auditory brainstem responses (ABRs) and distortion-product otoacoustic emissions (DPOAEs). Cochlear pathology was observed in cochleograms with Harris' hemat... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2778831 Thu, 03 Sep 2009 23:00:00 +0100 2778831 http://www.medworm.com/index.php?rid=2744475&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19714530%26dopt%3DAbstract Conclusion. The amendments made to pre-existing transcanal approaches limit the possibility of extrusion of the electrode and reduce the time of 'blind' surgery. Objective. Alternative techniques to classic mastoidectomy and posterior tympanotomy for cochlear implantation have already been described but their main drawbacks result in either: (i) the risk of an electrode extrusion through the skin as the groove is drilled into the auditory canal or (ii) the risk of a facial nerve injury as the tunnel is drilled blindly into the posterior canal wall. The aim of this study was to describe and evaluate a new transcanal approach for cochlear implantation ruling out these difficulties. Patients and methods. Through a minimal retroauricular skin incision, a cochleostomy is performed directly via ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2744475 Wed, 26 Aug 2009 23:00:00 +0100 2744475 http://www.medworm.com/index.php?rid=2744476&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19711207%26dopt%3DAbstract Conclusion. High risk perforations including total, subtotal, atelectatic perforations, those with cholesteatoma and revision cases can be treated efficiently with cartilage reinforcement tympanoplasty. Objective. The purpose of this study was to describe the perforation closure rates and hearing results of cartilage reinforcement tympanoplasty. Methods. This was a retrospective chart review and included 60 patients who underwent surgery with the cartilage reinforcement technique between November 2006 and October 2008 at the Department of Otorhinolaryngology of Haydarpasa Numune Research and Training Hospital, Istanbul, Turkey. The male to female ratio was 28 (46.7%)/32 (53.3%). The mean age of the patients was 30.10+/-11.50 years (range 13-55). Results. Preoperatively, only one patient ha... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2744476 Tue, 25 Aug 2009 23:00:00 +0100 2744476 http://www.medworm.com/index.php?rid=2738477&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19707901%26dopt%3DAbstract Conclusion. Increased psoriasin in cholesteatoma epithelium may play a role in epithelial inflammatory response and differentiation. Objectives. Cholesteatoma is characterized by excessive keratinocyte differentiation leading to inflammation, granulation tissue, and osteolytic activity. Moreover, psoriasin may act as an antimicrobial peptide, stimulate granulocytes, and control keratinocyte differentiation. The purpose of this study was to investigate the differential expression patterns and the localization of psoriasin in cholesteatoma and in normal external auditory canal skin. Materials and methods. Expression levels of psoriasin mRNA were evaluated by real-time PCR and Western blotting. Cholesteatoma-affected and normal external auditory canal skin samples were immunostained with mono... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2738477 Mon, 24 Aug 2009 23:00:00 +0100 2738477 http://www.medworm.com/index.php?rid=2738476&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19707902%26dopt%3DAbstract Conclusions. The buccal fat pad appears to be more useful as a source of fat tissues in intracordal fat injection than the abdominal fat tissues used previously. However, further studies are required to confirm this point. Objectives. Fat tissues used in vocal fold augmentation surgery have primarily been harvested from the subcutaneous region of the lower abdomen. It is often difficult to obtain sufficient fat tissue for injection due to the physical features of the individual patient. We have thus adopted a method using fat tissue from the buccal fat pad, which is already used in other plastic surgeries. Methods. This was a retrospective study. We evaluated and compared the histological characteristics of fat cells and the condition of vocal folds after injection of fat tissue extracted ... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2738476 Mon, 24 Aug 2009 23:00:00 +0100 2738476 http://www.medworm.com/index.php?rid=2738475&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19707903%26dopt%3DAbstract Conclusion. Neonatal olfactory ensheathing cells conditioned medium (OEC-CM) can promote growth and proliferation of neonatal spiral ganglion cells (SGCs), as well as protecting them from apoptosis. Objective. To investigate the effects of neonatal OEC-CM on the survival, apoptosis, and proliferation of spiral ganglion. Methods. SGCs were cultured with OEC-CM, the conditioned medium from olfactory nerve fibroblasts (ONF-CM) or control medium containing 10% serum (DF12-10S). After different periods of culture, the cell types present were identified by immunofluorescent confocal imaging analysis, cell proliferation was determined by BrdU incorporation, and apoptosis was detected with the double-labeled NeuroTACS in situ Apoptosis Detection Kit. Results. SGCs cultured with regular control med... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2738475 Mon, 24 Aug 2009 23:00:00 +0100 2738475 http://www.medworm.com/index.php?rid=2738474&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19707904%26dopt%3DAbstract Conclusion. Our study demonstrates (in cadavers) the ability to obtain a minimally invasive approach to access the petrous apex using patient-customized micro-stereotactic frames based on pre-intervention radiographic studies. Objective. To conduct in vitro studies to demonstrate the feasibility of percutaneous petrous apex access using customized, bone-mounted, micro-stereotactic frames. Methods. Cadaveric temporal bone specimens (n=10) were affixed with three bone-implanted fiducial markers. CT scans were obtained and used in planning, in reference to the fiducial markers, a straight transmastoid infralabyrinthine trajectory from the mastoid surface to the petrous apex without violating the basal turn of the cochlea or the carotid artery. A drill press was mounted on the customized frame... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2738474 Mon, 24 Aug 2009 23:00:00 +0100 2738474 http://www.medworm.com/index.php?rid=2738473&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19707905%26dopt%3DAbstract We report the investigation of the cause of isolated malleus fractures based on four recent patients at our clinic and five patients reported to us by Swedish otosurgeons. In recent years we have treated four patients with isolated malleus fractures. Colleagues in the Swedish Society of Otosurgeons were encouraged to send us reports on patients with diagnosed isolated malleus fractures, resulting in five more cases. A literature review focusing on the cause and management of this injury was also conducted. Eight of nine patients in the Swedish material had the same history. The patients had inserted a finger into the external auditory canal (most often after a bath) and then pulled it out. Immediately afterwards they experienced a short pain and a hearing loss. An audiogram revealed a cond... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2738473 Mon, 24 Aug 2009 23:00:00 +0100 2738473 http://www.medworm.com/index.php?rid=2716631&cid=s_25315_16_f&fid=25315&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19688619%26dopt%3DAbstract Conclusion: The novel midline electroneurography (ENoG) method may have advantages over the standard method in terms of ease of electrode setting, and the ENoG value may be a useful prognostic factor. Objective: We compared ENoG performed in patients with facial palsy using two different methods - the new midline method and standard method - in terms of the amplitudes of the compound muscle action potentials (CMAPs) and relationship between the ENoG value and clinical course. Methods: A total of 64 patients with facial palsy were enrolled. CMAPs were recorded using the midline method, in which the recording electrodes were placed on the mental protuberance and philtrum over the orbicularis oris muscle, and the standard method, in which the recording electrodes were set close to the nasolab... Acta Oto-Laryngologica journals http://www.medworm.com/rss/comments.php?id=2716631 Sun, 16 Aug 2009 23:00:00 +0100 2716631