MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Acta Paediatrica. Supplement' source. Mon, 30 Nov 2009 15:17:46 +0100 http://www.medworm.com/index.php?rid=2833558&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19764925%26dopt%3DAbstract Authors: PMID: 19764925 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=2833558 Sat, 26 Sep 2009 17:12:05 +0100 2833558 http://www.medworm.com/index.php?rid=2041761&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18564253%26dopt%3DAbstract Authors: PMID: 18564253 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=2041761 Sun, 01 Jun 2008 04:00:00 +0100 2041761 http://www.medworm.com/index.php?rid=2041762&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18363961%26dopt%3DAbstract Authors: PMID: 18363961 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=2041762 Tue, 01 Apr 2008 04:00:00 +0100 2041762 http://www.medworm.com/index.php?rid=1830206&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339197%26dopt%3DAbstract Authors: PMID: 18339197 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1830206 Tue, 01 Apr 2008 04:00:00 +0100 1830206 http://www.medworm.com/index.php?rid=1572153&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339179%26dopt%3DAbstract Authors: Aerts J, Beck M, Martin R, Scarpa M PMID: 18339179 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572153 Tue, 01 Apr 2008 04:00:00 +0100 1572153 http://www.medworm.com/index.php?rid=1572152&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339180%26dopt%3DAbstract Authors: Scarpa M, Eto Y PMID: 18339180 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572152 Tue, 01 Apr 2008 04:00:00 +0100 1572152 http://www.medworm.com/index.php?rid=1572151&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339181%26dopt%3DAbstract Conclusion: Besides direct applications for biomarkers in patient management, biomarker searches are likely to render new insights into pathophysiological mechanisms and metabolic adaptations, and may provide new targets for therapeutic intervention. PMID: 18339181 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572151 Tue, 01 Apr 2008 04:00:00 +0100 1572151 http://www.medworm.com/index.php?rid=1572150&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339182%26dopt%3DAbstract Conclusion: For many years this devastating disorder was considered untreatable and the outlook for patients was poor. Within a comparatively short period of time since the ASA gene was cloned in 1989, genetic and biochemical studies and data generated from newly developed animal models have led to the first clinical trials. It is hoped that these developments will prove beneficial for patients. PMID: 18339182 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572150 Tue, 01 Apr 2008 04:00:00 +0100 1572150 http://www.medworm.com/index.php?rid=1572149&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339183%26dopt%3DAbstract Conclusion: The development of gene transfer vectors that mediate persistent expression in vivo, the addition of PTDs, a better understanding of lysosomal enzyme trafficking and combining different therapies provide hope that the CNS component of LSDs can be effectively treated. PMID: 18339183 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572149 Tue, 01 Apr 2008 04:00:00 +0100 1572149 http://www.medworm.com/index.php?rid=1572148&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339184%26dopt%3DAbstract Authors: Mehta A, Parini R PMID: 18339184 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572148 Tue, 01 Apr 2008 04:00:00 +0100 1572148 http://www.medworm.com/index.php?rid=1572147&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339185%26dopt%3DAbstract Conclusion: With the advent of high-throughput assays for the detection of LSDs, newborn screening for these disorders may soon become a reality. However, careful prospective studies are required to optimize this process before it is used on a larger scale. PMID: 18339185 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572147 Tue, 01 Apr 2008 04:00:00 +0100 1572147 http://www.medworm.com/index.php?rid=1572146&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339186%26dopt%3DAbstract Conclusion: The manifestations of Fabry disease first become apparent during childhood. It is well known that disease-associated manifestations are progressive; however, it has yet to be determined whether specific treatment with enzyme replacement therapy can prevent the development of the associated severe and life-threatening complications. PMID: 18339186 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572146 Tue, 01 Apr 2008 04:00:00 +0100 1572146 http://www.medworm.com/index.php?rid=1572145&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339187%26dopt%3DAbstract Conclusion: If early intervention with ERT in females is to be advocated, it is necessary to demonstrate not only that females with Anderson-Fabry disease have clinical and biochemical features of alpha-galactosidase A deficiency and respond to ERT, but also that early intervention prevents the onset of the later manifestations of the disorder. Any strategy for early therapy should also balance future advantages against any impact on quality of life. PMID: 18339187 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572145 Tue, 01 Apr 2008 04:00:00 +0100 1572145 http://www.medworm.com/index.php?rid=1572144&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339188%26dopt%3DAbstract Conclusion: This study identifies a number of genes that are differentially expressed in a small cohort of children with Fabry disease relative to healthy controls. These genes may relate to the underlying biological abnormalities in Fabry disease. PMID: 18339188 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572144 Tue, 01 Apr 2008 04:00:00 +0100 1572144 http://www.medworm.com/index.php?rid=1572143&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339189%26dopt%3DAbstract Authors: Muenzer J, Martins AM PMID: 18339189 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572143 Tue, 01 Apr 2008 04:00:00 +0100 1572143 http://www.medworm.com/index.php?rid=1572142&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339190%26dopt%3DAbstract Conclusion: Respiratory abnormalities are a major contributor to the premature mortality seen in Hunter syndrome. Treatment of these respiratory problems requires the careful attention of clinicians skilled in the recognition, diagnosis, management and treatment of Hunter syndrome. PMID: 18339190 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572142 Tue, 01 Apr 2008 04:00:00 +0100 1572142 http://www.medworm.com/index.php?rid=1572141&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339191%26dopt%3DAbstract Conclusion: Future studies should focus on how structural and chemical signatures in the brain of Hunter patients are altered before and after enzyme replacement therapy, and how those alterations correlate with clinical outcome. PMID: 18339191 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572141 Tue, 01 Apr 2008 04:00:00 +0100 1572141 http://www.medworm.com/index.php?rid=1572140&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339192%26dopt%3DAbstract Conclusion: Treatment effects in patients with neurodegenerative LSRDs are best evaluated by repeated measures and longitudinal analysis of each domain of function. PMID: 18339192 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572140 Tue, 01 Apr 2008 04:00:00 +0100 1572140 http://www.medworm.com/index.php?rid=1572139&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339193%26dopt%3DAbstract Conclusion: This short review provides an overview of the natural history of MPS II and current experience of enzyme replacement therapy with idursulfase. PMID: 18339193 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572139 Tue, 01 Apr 2008 04:00:00 +0100 1572139 http://www.medworm.com/index.php?rid=1572138&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339194%26dopt%3DAbstract Authors: Bembi B, Deegan P PMID: 18339194 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572138 Tue, 01 Apr 2008 04:00:00 +0100 1572138 http://www.medworm.com/index.php?rid=1572137&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339195%26dopt%3DAbstract Conclusion: ERT currently remains the most effective treatment for Gaucher disease. New treatments are emerging, but deficiencies in understanding basic pathophysiological mechanisms hinder progress. PMID: 18339195 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572137 Tue, 01 Apr 2008 04:00:00 +0100 1572137 http://www.medworm.com/index.php?rid=1572136&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339196%26dopt%3DAbstract Conclusion: SRT is an oral alternative treatment option for patients with type 1 Gaucher disease unwilling or unable to receive ERT. With the recent reports of clinical improvement/stabilization of CNS manifestations following SRT in patients with Niemann-Pick disease type C, miglustat may also have a role to play in the management of patients with glycosphingolipid storage in the brain. Furthermore, as SRT synergises with other therapeutic modalities, it may also prove to be a key component of combination therapies in the future. PMID: 18339196 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572136 Tue, 01 Apr 2008 04:00:00 +0100 1572136 http://www.medworm.com/index.php?rid=1572135&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18339197%26dopt%3DAbstract Authors: PMID: 18339197 [PubMed - in process] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572135 Tue, 01 Apr 2008 04:00:00 +0100 1572135 http://www.medworm.com/index.php?rid=1572179&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17313407%26dopt%3DAbstract Authors: Cole TJ Child obesity is becoming a serious public health concern, and major research effort is being devoted both to understand its aetiology and to improve the effectiveness of prevention strategies. Early growth patterns, both prenatally and postnatally, are emerging as important markers of later obesity risk, with rapid neonatal weight gain a clear risk factor for later obesity and metabolic syndrome. Thus, in two distinct senses child obesity is a growing problem. The paper summarises current evidence on growth pattern and obesity, relating it to infant feeding practice and appetite regulation, and highlights the areas in which public health interventions are feasible. Of the conclusions drawn, one involves a futuristic solution to child obesity where neonates are given a... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572179 Sun, 01 Apr 2007 04:00:00 +0100 1572179 http://www.medworm.com/index.php?rid=1572178&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17313408%26dopt%3DAbstract We describe current projects in our own group that are designed to take forward these recommendations. PMID: 17313408 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572178 Sun, 01 Apr 2007 04:00:00 +0100 1572178 http://www.medworm.com/index.php?rid=1572177&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17313409%26dopt%3DAbstract In conclusion, half of the studies were successful and had an effect on either overweight or obesity. Much more research is needed in order to effectively prevent paediatric obesity. PMID: 17313409 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572177 Sun, 01 Apr 2007 04:00:00 +0100 1572177 http://www.medworm.com/index.php?rid=1572176&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17313410%26dopt%3DAbstract CONCLUSIONS: School-based health promotion has sustainable effects on nutritional knowledge and remission of overweight being most pronounced in girls. The effect of intervention was most pronounced using TSF and WC as criteria of overweight. PMID: 17313410 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572176 Sun, 01 Apr 2007 04:00:00 +0100 1572176 http://www.medworm.com/index.php?rid=1572175&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17313411%26dopt%3DAbstract In conclusion, since social and economic problems seem to increase the risk of weight gain more attention should be paid to environments that promote healthy weight maintenance. PMID: 17313411 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572175 Sun, 01 Apr 2007 04:00:00 +0100 1572175 http://www.medworm.com/index.php?rid=1572174&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17313412%26dopt%3DAbstract Authors: Kral TV, Faith MS There is relatively limited knowledge about the development of child eating patterns and how they may contribute to excess weight gain in early life. Particularly scarce are genetically informative studies that addressed environmental and genetic influences which can be challenging to disentangle. A review of this literature can help identify ongoing themes in the field and may stimulate new ideas for future research. The purpose of this paper is to provide an overview about how select environmental factors (e.g. the portion size of foods) and parental feeding practices (e.g. dietary restriction) can affect children's eating behaviour and weight status. The second part of the review explains in more detail the types of studies that can be employed to assess g... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572174 Sun, 01 Apr 2007 04:00:00 +0100 1572174 http://www.medworm.com/index.php?rid=1572173&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17313413%26dopt%3DAbstract Authors: Pietrobelli A, Malavolti M, Fuiano N, Faith MS Childhood and adolescence are decisive periods in human life. Body composition and psychological changes determine nutritional requirements as well as eating and physical activity behavior variability. Aims of the present paper are to discuss recent advances in measurements for quantifying total body and regional adiposity, and for mapping adipose tissue distribution in order to evaluate metabolic risk factors in children. Among the new methods available for assessing pediatric body composition, magnetic resonance imaging (MRI) can serve as a reference method for measuring tissue and organ volumes because estimates is reliable independent of age. MRI is the method of choice for calibrating field methods designed to measure adipose... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572173 Sun, 01 Apr 2007 04:00:00 +0100 1572173 http://www.medworm.com/index.php?rid=1572172&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17313414%26dopt%3DAbstract Authors: Nowicka P, Flodmark CE Changes in physical activity with the aim of increasing energy expenditure are usually an important component of childhood obesity treatment. Physical activity also has several other aspects that are positive for the obese child's health, such as improving the metabolic profile and psychological well being. The aim of this paper is to give a short review of what we know about physical activity in paediatric obesity treatment. In addition, practical recommendations will be presented which a health care provider can suggest to obese children and their families with a special focus on daily activity, participation in physical education classes and sports, sedentary behaviours, active commuting to school and how to get family and friends involved in supporti... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572172 Sun, 01 Apr 2007 04:00:00 +0100 1572172 http://www.medworm.com/index.php?rid=1572171&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391431%26dopt%3DAbstract Authors: von Figura K PMID: 17391431 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572171 Sun, 01 Apr 2007 04:00:00 +0100 1572171 http://www.medworm.com/index.php?rid=1572170&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391432%26dopt%3DAbstract CONCLUSION: Over half of the residues in the protein have been found to have changes in patients with Fabry disease. Most of these genetic mutations lead to disruption of the hydrophobic core of the protein, thus Fabry disease is primarily a disease of protein-folding. Further understanding of alpha-galactosidase A, one of the best studied members of the lysosomal storage disease family, will lead to increased understanding of other lysosomal storage diseases and other protein-folding diseases. PMID: 17391432 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572170 Sun, 01 Apr 2007 04:00:00 +0100 1572170 http://www.medworm.com/index.php?rid=1572169&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391433%26dopt%3DAbstract CONCLUSION: For a given protein, changes in the type of host cell, composition of the culture media and fermentation conditions during process development will most likely result in changes in the site occupation and heterogeneity of glycosylation. This, of course, can influence the therapeutic profile. Therefore, the early selection of the host cell and selection of upstream parameters are key in the process development of a product. PMID: 17391433 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572169 Sun, 01 Apr 2007 04:00:00 +0100 1572169 http://www.medworm.com/index.php?rid=1572168&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391435%26dopt%3DAbstract Authors: Kolodny E PMID: 17391435 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572168 Sun, 01 Apr 2007 04:00:00 +0100 1572168 http://www.medworm.com/index.php?rid=1572167&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391436%26dopt%3DAbstract CONCLUSION: This broader view of the role of lysosomes in cells not only provides insight into how single gene defects impacting on lysosomal function can result in the plethora of complex cellular transformations characteristic of these diseases, but also suggests new and innovative therapies that may hold considerable promise for ameliorating disease progression. PMID: 17391436 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572167 Sun, 01 Apr 2007 04:00:00 +0100 1572167 http://www.medworm.com/index.php?rid=1572166&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391437%26dopt%3DAbstract CONCLUSION: DTI is more sensitive in detecting brain tissue changes in Fabry disease than conventional MRI. DTI measurements could provide appropriate surrogate parameters with which to monitor the natural history of structural brain involvement and potential effects of therapy (such as enzyme replacement) in Fabry disease. PMID: 17391437 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572166 Sun, 01 Apr 2007 04:00:00 +0100 1572166 http://www.medworm.com/index.php?rid=1572165&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391439%26dopt%3DAbstract Authors: Gieselmann V PMID: 17391439 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572165 Sun, 01 Apr 2007 04:00:00 +0100 1572165 http://www.medworm.com/index.php?rid=1572164&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391440%26dopt%3DAbstract CONCLUSION: Identification of potential intracellular targets of S1P remains a crucial objective for attaining a better understanding of the potent role this molecule plays in regulating cell fate. PMID: 17391440 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572164 Sun, 01 Apr 2007 04:00:00 +0100 1572164 http://www.medworm.com/index.php?rid=1572163&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391441%26dopt%3DAbstract CONCLUSION: We conclude that sphingomyelin metabolites are important endogenous modulators of vascular function, which may contribute to the pathophysiology of some diseases and be targets for therapeutic interventions. PMID: 17391441 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572163 Sun, 01 Apr 2007 04:00:00 +0100 1572163 http://www.medworm.com/index.php?rid=1572162&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391442%26dopt%3DAbstract CONCLUSION: Most investigations of the effects of the S1P-S1P(1) axis in immunity have focused primarily on rapid, transient alterations in lymphocyte migration and trafficking, and on mast cell migration and secretion of chemical mediators. The discovery of functional S1P(1)-G protein signalling complexes in the nuclear membranes of activated lymphocytes, that are coupled to the transduction of prolonged inhibition of proliferative responses by intracellular S1P, adds a new dimension to the role of the S1P-S1P(1) axis in immunity. Recruitment of this novel, potentially immunosuppressive, function of S1P(1) may be beneficial in some autoimmune diseases and will require application of cell membrane-permeant S1P(1)-specific drugs. PMID: 17391442 [PubMed - indexed for MEDLINE] (Source: Ac... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572162 Sun, 01 Apr 2007 04:00:00 +0100 1572162 http://www.medworm.com/index.php?rid=1572161&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391444%26dopt%3DAbstract Authors: Beck M, Wraith E PMID: 17391444 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572161 Sun, 01 Apr 2007 04:00:00 +0100 1572161 http://www.medworm.com/index.php?rid=1572160&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391445%26dopt%3DAbstract CONCLUSION: Animal models of human genetic disease continue to play an important role in understanding the molecular and physiological consequences of lysosomal storage diseases and to provide an opportunity to evaluate the efficacy and safety of therapeutic interventions. PMID: 17391445 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572160 Sun, 01 Apr 2007 04:00:00 +0100 1572160 http://www.medworm.com/index.php?rid=1572159&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391446%26dopt%3DAbstract CONCLUSION: Our results suggest that there is a considerable delay between the onset of signs and symptoms and the diagnosis of MPS II in Brazil (and probably in South America as well), and that many complications of this disease are underdiagnosed and undertreated. Therefore, the implementation of programmes aiming to increase the awareness of the disease, the availability of biochemical diagnostic tests and the provision of better support to affected patients is urgently needed. PMID: 17391446 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572159 Sun, 01 Apr 2007 04:00:00 +0100 1572159 http://www.medworm.com/index.php?rid=1572158&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391447%26dopt%3DAbstract CONCLUSION: Although genotype-phenotype correlations may be difficult to establish, they will be of increasing importance for choosing the most appropriate therapy for an individual patient, as new therapeutic strategies may be targeted according to phenotype. PMID: 17391447 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572158 Sun, 01 Apr 2007 04:00:00 +0100 1572158 http://www.medworm.com/index.php?rid=1572157&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391449%26dopt%3DAbstract CONCLUSION: In the era of enzyme replacement therapy, conventional pharmacological and device-based therapies remain central to the management of cardiovascular symptoms and the prevention of complications, such as arrhythmia and stroke. PMID: 17391449 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572157 Sun, 01 Apr 2007 04:00:00 +0100 1572157 http://www.medworm.com/index.php?rid=1572156&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391450%26dopt%3DAbstract CONCLUSION: Gastrointestinal symptoms in Fabry disease may have been underestimated. The FOS database supports previous reports of beneficial effects of enzyme replacement therapy on gastrointestinal symptoms in Fabry disease. PMID: 17391450 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572156 Sun, 01 Apr 2007 04:00:00 +0100 1572156 http://www.medworm.com/index.php?rid=1572155&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391451%26dopt%3DAbstract Authors: Lavery C, Ramaswami U PMID: 17391451 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572155 Sun, 01 Apr 2007 04:00:00 +0100 1572155 http://www.medworm.com/index.php?rid=1572154&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17391452%26dopt%3DAbstract Authors: Romero MA, Milligan A, Briva J, Basalla D PMID: 17391452 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572154 Sun, 01 Apr 2007 04:00:00 +0100 1572154 http://www.medworm.com/index.php?rid=1572195&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000563%26dopt%3DAbstract CONCLUSIONS: The policy recommendations are important input for policy advisers, policy makers and public health authorities at all policy levels. The recommendations are also of direct relevance to interest groups, such as environmental NGOs including child health and advocacy groups. The policy recommendations for each policy level were prioritized. High priorities were given to reduce exposure to environmental tobacco smoke, transport related air pollution, indoor air and mercury. PMID: 17000563 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572195 Sun, 01 Oct 2006 04:00:00 +0100 1572195 http://www.medworm.com/index.php?rid=1572194&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000564%26dopt%3DAbstract Authors: ten Tusscher GW, Leijs MM, Koppe JG Environmental health history taking is often not part of standard medical history taking for clinical physicians. During recent years attention has been placed on home environments and asthma and allergies, high caloric intake and obesity and type 2 diabetes mellitus, yet environmental health history taking still remains relatively uncharted terrain for the clinical physicians of today. While the reasons for this are certainly varied, ignorance of environmental influences, ignorance of environmental pollutants, politics and prejudices will certainly play a role. We suggest a simple manner of environmental health history taking, and discuss the importance of the subject in our modern-day clinical practice. PMID: 17000564 [PubMed - indexed... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572194 Sun, 01 Oct 2006 04:00:00 +0100 1572194 http://www.medworm.com/index.php?rid=1572193&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000565%26dopt%3DAbstract CONCLUSIONS: The following recommendations for action are formulated: Immediate research on endocrine disrupters in relation to prematurity. Diabetes: avoid Maillard Compounds in liquid baby food and in food in general: promote breastfeeding. Asthma: avoid exposure to smoking, the use of chemical household products, dioxin and dioxin-like chemicals, and avoid air pollution with high levels of particulate matter, especially around conception, during pregnancy and in the first years of life. Autism: more research on incidence and causes. ADHD and learning disabilities: more research on prevalence and causes. Preventions: 1) preconception counselling to avoid potentially harmful substances; 2) controlling and further lowering levels of polychlorinated biphenyls, lead and methyl mercury. Cance... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572193 Sun, 01 Oct 2006 04:00:00 +0100 1572193 http://www.medworm.com/index.php?rid=1572192&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000566%26dopt%3DAbstract CONCLUSIONS: There is a need to improve research on social inequalities in children's health and environment. Because of the complexity, integrated approaches and a combination of different intervention measures and policies are necessary to reduce environmental exposure and adverse health effects in children. Paediatricians may contribute to improvement of children's environmental health by risk communication and health advocacy at community and governmental level. PMID: 17000566 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572192 Sun, 01 Oct 2006 04:00:00 +0100 1572192 http://www.medworm.com/index.php?rid=1572191&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000567%26dopt%3DAbstract CONCLUSION: The policy recommendations the Policy Interpretation Network on Children's Health and Environment (PINCHE) prepared for each age group or setting are described here. PMID: 17000567 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572191 Sun, 01 Oct 2006 04:00:00 +0100 1572191 http://www.medworm.com/index.php?rid=1572190&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000568%26dopt%3DAbstract Authors: Ronchetti R, Zuurbier M, Jesenak M, Koppe JG, Ahmed UF, Ceccatelli S, Villa MP The reason why mercury is dangerous is that once released into the environment it cannot be removed and is rapidly transformed by microorganisms into organic compounds that tend to bioaccumulate and biomagnify in animals. The principal organic compound is methylmercury (MeHg). The primary route of exposure to MeHg for humans is consumption of fish. The safe dose (reference dose, RfD) of MeHg that can be consumed without neurotoxicological consequences is 0.1 microg per kg b.w./day. According to available data, the whole population of certain European countries or people who consume large quantities of fish are exposed to doses of MeHg that exceed the RfD. Given this level of mercury exposure, in ord... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572190 Sun, 01 Oct 2006 04:00:00 +0100 1572190 http://www.medworm.com/index.php?rid=1572189&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000569%26dopt%3DAbstract Authors: Ronchetti R, van den Hazel P, Schoeters G, Hanke W, Rennezova Z, Barreto M, Villa MP Numerous studies indicate that low-level lead poisoning causes mild mental retardation and low IQ scores in children. The general mean lead intake in the adult European population corresponds to a reassuring 14% (0.5-56%) of the tolerable daily intake: at this low level of exposure only few children (less than 10%) have blood lead levels (PbB) higher than 10 microg/dl, previously considered the PbB of concern. In more recent years data now suggest that even when 'the lifetime average blood lead concentration' is below 10 microg/dl an inverse association exists with intelligence quotient (IQ) scores. Two-thirds (45-75%) of lead in blood, however, comes from long-term tissue stores and this is e... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572189 Sun, 01 Oct 2006 04:00:00 +0100 1572189 http://www.medworm.com/index.php?rid=1572188&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000570%26dopt%3DAbstract Authors: Schoeters G, Den Hond E, Zuurbier M, Naginiene R, van den Hazel P, Stilianakis N, Ronchetti R, Koppe JG Cadmium exposure and accumulation in the body start at young age. Exposure routes in children are mainly via food, environmental tobacco smoke and house dust. Excretion from the body is limited. Cadmium accumulation in the kidney is responsible for effects such as nephrotoxicity and osteoporosis which are observed at adult age. Cadmium exposure through inhalation is also associated with lung cancer in adulthood. Although transfer to the neonate through the placenta and through breast milk is limited, teratogenic and developmental effects were observed in experimental animals. The database on human studies involving children is limited, yet effects on motoric and perceptual b... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572188 Sun, 01 Oct 2006 04:00:00 +0100 1572188 http://www.medworm.com/index.php?rid=1572187&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000571%26dopt%3DAbstract CONCLUSION/SUGGESTED ACTION: Some measures aimed at reducing exposure to dioxins have been partly successful in that the dioxin content of breast milk is going down. However, further steps to reduce exposure must be taken. We suggest legislative measures for reducing the re-entry of especially PCBs from waste into the environment. Individual pre-conception counselling is recommended in order to reduce developmental exposure and its consequences. Biomonitoring of the substances themselves in breast milk and foods is recommended as well as monitoring possible endocrine effects. PMID: 17000571 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572187 Sun, 01 Oct 2006 04:00:00 +0100 1572187 http://www.medworm.com/index.php?rid=1572186&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000572%26dopt%3DAbstract CONCLUSIONS: The EU has banned the production and use of penta- and octa-BDE since 2004; however, exposure will continue during the coming decades. Based upon current toxicological evidence, human exposure to deca-BDEs is not expected to lead to health effects, but data on exposure to deca-BDE and data on toxicity of deca-BDE are scarce. Therefore, monitoring studies and toxicity studies on deca-BDEs and other BDEs should continue. PMID: 17000572 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572186 Sun, 01 Oct 2006 04:00:00 +0100 1572186 http://www.medworm.com/index.php?rid=1572185&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000573%26dopt%3DAbstract CONCLUSIONS: Current knowledge about tolerable levels and consequences of toxic exposure to pesticides during human development is rather scarce. Owing to the high risk of exposure to pesticides, particularly in less developed countries, further elucidation by well-controlled epidemiological studies in this field it is urgently needed. The Policy Interpretation Network on Children's Health and Environment (PINCHE), which is financed by the EU DG research has suggested actions against pesticide exposure. They have been presented and discussed in this paper. Several suggestions of PINCHE concerning action needed regarding pesticides were presented in the paper. PMID: 17000573 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572185 Sun, 01 Oct 2006 04:00:00 +0100 1572185 http://www.medworm.com/index.php?rid=1572184&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000574%26dopt%3DAbstract Authors: Busby C, Fucic A PMID: 17000574 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572184 Sun, 01 Oct 2006 04:00:00 +0100 1572184 http://www.medworm.com/index.php?rid=1572183&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000575%26dopt%3DAbstract CONCLUSIONS: Protecting children from ETS exposure is a complex and important issue. The best improvement in children's health is to be gained when parents stop smoking or, when that is not possible, they stop smoking in their children's environment. Paediatricians, because of their authority, and their frequent and regular contact with parents, play a leading role in protecting children from ETS exposure. An ideal approach to help parents to stop smoking seems to be initial minimal-contact advice provided by their paediatrician with feedback and supplemental printed materials, leading to greater intensity and duration of follow-up home visits. PMID: 17000575 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572183 Sun, 01 Oct 2006 04:00:00 +0100 1572183 http://www.medworm.com/index.php?rid=1572182&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000576%26dopt%3DAbstract CONCLUSIONS: Medical doctors have a responsibility to know the facts and to advise their patients. Doctors when visiting their patients' homes should be aware of the possibly grave impact of the indoor environment for the respiratory health of their patients. They should recognize and advise the parents on problems associated with environmental tobacco smoke, poor ventilation, mould growth, and maintenance of heating installations. With regard to outdoor air pollution, doctors could serve as role models and also advise their patients and parents on environmentally friendly behaviour. Such behaviour not only calls for personal commitment but also for the right infrastructure to be provided (e.g. public transport, district heating). Doctors should be proactive in the community and in their c... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572182 Sun, 01 Oct 2006 04:00:00 +0100 1572182 http://www.medworm.com/index.php?rid=1572181&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000577%26dopt%3DAbstract CONCLUSIONS: It is necessary to define and study groups of multiple stressors as in US EPA's Framework for Cumulative Risk Assessment (U.S. EPA 2003). Recent increased knowledge of the greater sensitivity of the unborn baby, the infant and the child, has led to general recognition that a higher degree of precaution is now needed in regulating for multiple stressors on the young. The more liberal permissive approach proceeding from established effects of the individual exposures is becoming less acceptable now that we know that there is much we do not understand about chronic effects of stressors during the early development phases. Conflicts over which approach to take may have to be resolved through engagement and negotiation with a wide community of stakeholders. This "community of inter... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572181 Sun, 01 Oct 2006 04:00:00 +0100 1572181 http://www.medworm.com/index.php?rid=1572180&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17000578%26dopt%3DAbstract CONCLUSIONS: PINCHE provided recommendations to reduce exposure for children. Exposure reduction is not always linked to improved health in the short term, but it will reduce the body burden of accumulating chemicals in children. A strategic choice is reduction of exposure of children to compounds by changing production techniques or by increasing the distance of child specific settings to sources. The contribution of all players in the production, distribution and use of scientific knowledge in the field of children's environmental health is necessary. PMID: 17000578 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572180 Sun, 01 Oct 2006 04:00:00 +0100 1572180 http://www.medworm.com/index.php?rid=1572216&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16801157%26dopt%3DAbstract Conclusion: Further, long-term studies will be needed to address the optimal use of this hormone in each of these conditions. PMID: 16801157 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572216 Sat, 01 Jul 2006 04:00:00 +0100 1572216 http://www.medworm.com/index.php?rid=1572215&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16801158%26dopt%3DAbstract CONCLUSION: In this review, we discuss the rationale for and possibility of using growth hormone therapy in some conditions not strictly related to growth hormone deficiency. PMID: 16801158 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572215 Sat, 01 Jul 2006 04:00:00 +0100 1572215 http://www.medworm.com/index.php?rid=1572214&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16801159%26dopt%3DAbstract CONCLUSION: The high long-term survival rate observed in our children with myocarditis is probably due to the effect of short-term immunosuppression. This result is at odds with previously published series of conventionally treated children, whose survival probability at 1 y was approximately 0.60. PMID: 16801159 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572214 Sat, 01 Jul 2006 04:00:00 +0100 1572214 http://www.medworm.com/index.php?rid=1572213&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16801160%26dopt%3DAbstract CONCLUSION: Collectively, family-based studies of DCM provide the rationale for clinical screening in first-degree relatives, regardless of family history or age of the index case. PMID: 16801160 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572213 Sat, 01 Jul 2006 04:00:00 +0100 1572213 http://www.medworm.com/index.php?rid=1572212&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16801161%26dopt%3DAbstract CONCLUSION: Morphology of pulmonary blood supply has no major impact on surgical outcome. Pulmonary flow study is a highly specific and sensitive intraoperative test. Chromosome 22q11.2 microdeletion remains the only variable significantly affecting survival. PMID: 16801161 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572212 Sat, 01 Jul 2006 04:00:00 +0100 1572212 http://www.medworm.com/index.php?rid=1572211&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16801162%26dopt%3DAbstract Authors: Milliner DS Genetic disorders of mineral metabolism cause urolithiasis, renal disease, and osteodystrophy. Most are rare, such that the full spectrum of clinical expression is difficult to appreciate. Diagnosis is further complicated by overlap of clinical features. Dent's disease and primary hyperoxaluria, inherited causes of calcium urolithiasis, are both associated with nephrocalcinosis and urolithiasis in early childhood and renal failure that can occur at any age but is seen more often in adulthood. Bone disease is an inconsistent feature of each. Dent's disease is caused by mutations of the CLCN-5 gene with impaired kidney-specific CLC-5 chloride channel expression in the proximal tubule, thick ascending limb of Henle, and the collecting ducts. Resulting hypercalciuria a... Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572211 Sat, 01 Jul 2006 04:00:00 +0100 1572211 http://www.medworm.com/index.php?rid=1572210&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16801163%26dopt%3DAbstract CONCLUSION: Following new achievements in the genetics of cystinuria, a new classification has been proposed. Cystinuria is more severe in males than in females, but only rarely leads to renal insufficiency. The two types of cystinuria have a similar clinical outcome. A combined medical treatment may be effective in reducing renal stone incidence. PMID: 16801163 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572210 Sat, 01 Jul 2006 04:00:00 +0100 1572210 http://www.medworm.com/index.php?rid=1572209&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16801164%26dopt%3DAbstract CONCLUSION: This review focuses on the role of surgery in managing gastrointestinal aspects in children with CP and, in particular, surgical experience at our department with fundoplication, PEG placement and ligation of salivary ducts. PMID: 16801164 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572209 Sat, 01 Jul 2006 04:00:00 +0100 1572209 http://www.medworm.com/index.php?rid=1572208&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16801165%26dopt%3DAbstract CONCLUSION: Our data, together with a similar, published observation, suggest that the TNF inhibitor etanercept is potentially useful for obtaining remission in children not responding to steroids and cyclosporin A. PMID: 16801165 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572208 Sat, 01 Jul 2006 04:00:00 +0100 1572208 http://www.medworm.com/index.php?rid=1572207&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16801166%26dopt%3DAbstract CONCLUSION: Ethically problematic clinical cases are approached differently in the various countries. The findings of this study may provide an opportunity for physicians to review their practices critically, in light of how other colleagues proceed, and foster an open discussion about these difficult issues. PMID: 16801166 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572207 Sat, 01 Jul 2006 04:00:00 +0100 1572207 http://www.medworm.com/index.php?rid=1572206&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16801167%26dopt%3DAbstract CONCLUSION: It is extremely important to stratify patients for prognosis, taking into account clinical and biological variables with independent prognostic value. The aim is to select more adequate, risk-adapted, therapeutic strategies which also consider related or unrelated bone marrow transplant consolidation for patients with very poor prognosis. PMID: 16801167 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572206 Sat, 01 Jul 2006 04:00:00 +0100 1572206 http://www.medworm.com/index.php?rid=1572234&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720457%26dopt%3DAbstract Authors: PMID: 16720457 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572234 Sat, 01 Apr 2006 05:00:00 +0100 1572234 http://www.medworm.com/index.php?rid=1572233&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720458%26dopt%3DAbstract Authors: Chabás A, Happle R PMID: 16720458 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572233 Sat, 01 Apr 2006 05:00:00 +0100 1572233 http://www.medworm.com/index.php?rid=1572232&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720459%26dopt%3DAbstract Conclusion: Past assumptions regarding factors that may affect phenotype in heterozygous females do not capture the extraordinarily variable expressivity of X-linked disorders in females and need to be revisited. PMID: 16720459 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572232 Sat, 01 Apr 2006 05:00:00 +0100 1572232 http://www.medworm.com/index.php?rid=1572231&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720460%26dopt%3DAbstract Conclusion: In the various X-linked skin disorders, affected women show quite dissimilar degrees of involvement and forms of manifestation because X inactivation may give rise to different patterns of functional mosaicism. Paradoxically, no such pattern is observed in women with Fabry disease. Like many X-linked diseases, Fabry disease should neither be called recessive nor dominant, because these dichotomous terms are obscured by the mechanism of X inactivation. PMID: 16720460 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572231 Sat, 01 Apr 2006 05:00:00 +0100 1572231 http://www.medworm.com/index.php?rid=1572230&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720461%26dopt%3DAbstract Conclusion: The process of X inactivation and the resultant degree of skewing is clearly important for the expression of genetic diseases. It is also important to consider, however, that under normal conditions the frequency of skewed X inactivation increases with age in peripheral blood cells. Analysis of the expression of a large proportion of the genes on the X chromosome has revealed that X-chromosome inactivation is more heterogeneous than previously thought. PMID: 16720461 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572230 Sat, 01 Apr 2006 05:00:00 +0100 1572230 http://www.medworm.com/index.php?rid=1572229&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720462%26dopt%3DAbstract CONCLUSION: In this study we provide evidence that heterozygous females with Fabry disease show random X inactivation. Our data do not support the hypothesis that the occurrence and severity of disease manifestations in the majority of Fabry heterozygotes are related to skewed X inactivation. PMID: 16720462 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572229 Sat, 01 Apr 2006 05:00:00 +0100 1572229 http://www.medworm.com/index.php?rid=1572228&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720463%26dopt%3DAbstract Authors: Beck M, Widmer U PMID: 16720463 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572228 Sat, 01 Apr 2006 05:00:00 +0100 1572228 http://www.medworm.com/index.php?rid=1572227&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720464%26dopt%3DAbstract Conclusion: The MSSI score has been proven to be representative in patients with 'classic' Fabry disease and may be useful for monitoring clinical improvement in patients receiving enzyme replacement therapy. PMID: 16720464 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572227 Sat, 01 Apr 2006 05:00:00 +0100 1572227 http://www.medworm.com/index.php?rid=1572226&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720465%26dopt%3DAbstract CONCLUSION: Experience gained from the use of staging and scoring systems in haematology provides useful insights into their potential use in Fabry disease and other lysosomal storage diseases. Such systems may help to predict whom to treat, when to treat and what response is likely to be achieved. PMID: 16720465 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572226 Sat, 01 Apr 2006 05:00:00 +0100 1572226 http://www.medworm.com/index.php?rid=1572225&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720466%26dopt%3DAbstract Authors: Kolodny EH, Pastores GM PMID: 16720466 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572225 Sat, 01 Apr 2006 05:00:00 +0100 1572225 http://www.medworm.com/index.php?rid=1572224&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720467%26dopt%3DAbstract Conclusion: MRI is a valuable resource for assessing the CNS complications of Fabry disease, and their response to time and treatment. PMID: 16720467 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572224 Sat, 01 Apr 2006 05:00:00 +0100 1572224 http://www.medworm.com/index.php?rid=1572223&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720468%26dopt%3DAbstract CONCLUSION: This study presents evidence of a major increase in common carotid artery IMT, both in hemizygous and heterozygous patients with Fabry disease, in the absence of focal atherosclerotic plaques. These results suggest that the conduit arteries may be protected from atherosclerosis in Fabry disease. PMID: 16720468 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572223 Sat, 01 Apr 2006 05:00:00 +0100 1572223 http://www.medworm.com/index.php?rid=1572222&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720469%26dopt%3DAbstract Conclusion: Future developments in array technology for proteins and DNA single nucleotide polymorphism analysis, together with gene expression microarray analysis, may open a new chapter in our understanding of the biology of lysosomal storage disorders. PMID: 16720469 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572222 Sat, 01 Apr 2006 05:00:00 +0100 1572222 http://www.medworm.com/index.php?rid=1572221&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720470%26dopt%3DAbstract Authors: Cox TM, Beck M PMID: 16720470 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572221 Sat, 01 Apr 2006 05:00:00 +0100 1572221 http://www.medworm.com/index.php?rid=1572220&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720471%26dopt%3DAbstract CONCLUSION: Each lysosomal storage disorder and each patient with a given lysosomal disorder has unique molecular, pathological and clinical features. But, the order of pathological events is largely the same. Mutations in a gene cause lysosomal dysfunction which, in turn, results in cellular pathology affecting organ structure and function. Clinical symptoms are the ultimate manifestation. The reversibility of symptoms with enzyme replacement therapy will vary according to the disease, as well as the nature and stage of organ pathology. PMID: 16720471 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572220 Sat, 01 Apr 2006 05:00:00 +0100 1572220 http://www.medworm.com/index.php?rid=1572219&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720472%26dopt%3DAbstract Conclusion: It is hoped that the new pathogenetic insights into diabetic kidney disease may facilitate the development of new drugs for the treatment of this and related kidney diseases. PMID: 16720472 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572219 Sat, 01 Apr 2006 05:00:00 +0100 1572219 http://www.medworm.com/index.php?rid=1572218&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720473%26dopt%3DAbstract CONCLUSION: Studies in animal models have identified numerous factors that influence the therapeutic efficacy of ERT. This would suggest that in patients affected by LSDs rigorous evaluation of each therapeutic preparation will be needed. PMID: 16720473 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572218 Sat, 01 Apr 2006 05:00:00 +0100 1572218 http://www.medworm.com/index.php?rid=1572217&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16720474%26dopt%3DAbstract Conclusion: The lessons that we have learned from Gaucher disease may well be applicable to the development of therapies for some of the other less common lysosomal storage diseases. PMID: 16720474 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572217 Sat, 01 Apr 2006 05:00:00 +0100 1572217 http://www.medworm.com/index.php?rid=1572205&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16817674%26dopt%3DAbstract CONCLUSION: The MGRS criteria were effective in selecting healthy children with comparable affluent backgrounds across sites and similar characteristics between longitudinal and cross-sectional samples within sites. PMID: 16817674 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572205 Sat, 01 Apr 2006 05:00:00 +0100 1572205 http://www.medworm.com/index.php?rid=1572204&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16817675%26dopt%3DAbstract CONCLUSION: The MGRS lactation support teams were successful in enhancing breastfeeding practices and achieving high rates of compliance with the feeding criteria required for the construction of the new growth standards. PMID: 16817675 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572204 Sat, 01 Apr 2006 05:00:00 +0100 1572204 http://www.medworm.com/index.php?rid=1572203&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16817676%26dopt%3DAbstract CONCLUSION: Complementary diets in the MGRS met global recommendations and were adequate to support physiological growth. PMID: 16817676 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572203 Sat, 01 Apr 2006 05:00:00 +0100 1572203 http://www.medworm.com/index.php?rid=1572202&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16817677%26dopt%3DAbstract CONCLUSION: Reliability of the MGRS teams compared well with the study's anthropometry expert and published reliability statistics. PMID: 16817677 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572202 Sat, 01 Apr 2006 05:00:00 +0100 1572202 http://www.medworm.com/index.php?rid=1572201&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16817678%26dopt%3DAbstract CONCLUSION: These results show that the criteria used to define performance of the milestones were similar and applied with equally high levels of reliability among fieldworkers within a site, among milestones within a site, and among sites across milestones. PMID: 16817678 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572201 Sat, 01 Apr 2006 05:00:00 +0100 1572201 http://www.medworm.com/index.php?rid=1572200&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16817679%26dopt%3DAbstract CONCLUSION: The striking similarity in linear growth among children in the six sites justifies pooling the data and constructing a single international standard from birth to 5 y of age. PMID: 16817679 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572200 Sat, 01 Apr 2006 05:00:00 +0100 1572200 http://www.medworm.com/index.php?rid=1572199&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16817680%26dopt%3DAbstract CONCLUSION: Inter-site differences, most likely due to culture-specific care behaviours, reflect normal development among healthy populations across the wide range of cultures and environments included in the MGRS. These analyses support the appropriateness of pooling data from all sites and for both sexes for the purpose of developing an international standard for gross motor development. PMID: 16817680 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572199 Sat, 01 Apr 2006 05:00:00 +0100 1572199 http://www.medworm.com/index.php?rid=1572198&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16817681%26dopt%3DAbstract CONCLUSION: The WHO Child Growth Standards depict normal growth under optimal environmental conditions and can be used to assess children everywhere, regardless of ethnicity, socio-economic status and type of feeding. PMID: 16817681 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572198 Sat, 01 Apr 2006 05:00:00 +0100 1572198 http://www.medworm.com/index.php?rid=1572197&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16817682%26dopt%3DAbstract CONCLUSION: The windows represent normal variation in ages of milestone achievement among healthy children. They are recommended for descriptive comparisons among populations, to signal the need for appropriate screening when individual children appear to be late in achieving the milestones, and to raise awareness about the importance of overall development in child health. PMID: 16817682 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572197 Sat, 01 Apr 2006 05:00:00 +0100 1572197 http://www.medworm.com/index.php?rid=1572196&cid=s_37351_33_f&fid=37351&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16817683%26dopt%3DAbstract CONCLUSION: Sporadic, significant associations were observed between gross motor development and some physical growth indicators, but these were quantitatively of limited practical significance. These results suggest that, in healthy populations, the attainment of these six gross motor milestones is largely independent of variations in physical growth. PMID: 16817683 [PubMed - indexed for MEDLINE] (Source: Acta Paediatrica. Supplement) Acta Paediatrica. Supplement journals http://www.medworm.com/rss/comments.php?id=1572196 Sat, 01 Apr 2006 05:00:00 +0100 1572196