MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Adv Data' source. Mon, 06 Feb 2012 11:13:12 +0100 http://www.medworm.com/index.php?rid=5651690&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22281300%26dopt%3DAbstract Authors: Watson T, Macdonald D, Song X, Bromwich K, Campos J, Sande J, Debiasi RL Abstract Adenovirus (AdV) infections are a major cause of morbidity and mortality in hematopoietic stem cell transplant HSCT) patients. To evaluate the use of molecular AdV testing in HSCT at our institution and identify risk factors for AdV viremia and disease, we performed a retrospective cohort study of all HSCT patients who had undergone AdV polymerase chain reaction (PCR) testing, over a two year period. Two cohorts were identified: Cohort 1 consisted of patients testing positive for AdV (n=7); Cohort 2 consisted of patients testing negative (n=36). Overall patient characteristics were not statistically different between cohorts. The following medication exposures were identified as risk factors ... Adv Data journals http://www.medworm.com/rss/comments.php?id=5651690 Mon, 23 Jan 2012 05:00:00 +0100 5651690 http://www.medworm.com/index.php?rid=5617925&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22257108%26dopt%3DAbstract CONCLUSIONS: All the oral anti-viral agents were associated with improved virological, biochemical and clinical parameters at 1-year. However, the efficacy of lamivudine and telbivudine is limited by drug resistance, and adefovir is limited by its potency and slower onset of action. Additional studies of tenofovir and entecavir are needed to determine the optimal agent(s) for treatment naïve patients and in those with drug-resistant decompensated HBV cirrhosis. PMID: 22257108 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5617925 Thu, 19 Jan 2012 05:00:00 +0100 5617925 http://www.medworm.com/index.php?rid=5594468&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22223155%26dopt%3DAbstract Authors: Wang ZL Abstract Utilizing the piezoelectric effect of ZnO nanowires, nanogenerators have been fabricated for producing an output of 10-20 V. On page 280, Zhong Lin Wang demonstrates a self-powered system by integrating a nanogenerator with sensors, energy storage units, a data processor, and a wireless transmitter, which can operate without a battery by harvesting mechanical energy from the environment. Such systems have application in biomedical science, environmental monitoring, structural monitoring, and personal electronics. PMID: 22223155 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5594468 Tue, 10 Jan 2012 05:00:00 +0100 5594468 http://www.medworm.com/index.php?rid=5594467&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22226087%26dopt%3DAbstract CONCLUSIONS: The effectiveness of the combination therapy was not obviously predominant over the monotherapy in short duration therapies; however, the combination therapy had a great advantage over monotherapy in both biochemical and virological response when the therapy duration was prolonged to >12 months. PMID: 22226087 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5594467 Wed, 04 Jan 2012 05:00:00 +0100 5594467 http://www.medworm.com/index.php?rid=5594466&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22229679%26dopt%3DAbstract Conclusion: While there is some data to suggest that CLRT may have an impact on prevention of and treatment for nosocomial infections acquired by ventilated patients, there still remains insufficient evidence to its inclusion as a fully validated treatment. Clearly, there is a requirement for more robust, in-depth research into the efficacy of this proposed treatment. PMID: 22229679 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5594466 Sun, 01 Jan 2012 05:00:00 +0100 5594466 http://www.medworm.com/index.php?rid=5523668&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22157660%26dopt%3DAbstract Conclusions: The state of prior oral health can influence decisively the mucositis suffered during transplantation. PMID: 22157660 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5523668 Tue, 06 Dec 2011 05:00:00 +0100 5523668 http://www.medworm.com/index.php?rid=5409345&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22068636%26dopt%3DAbstract Authors: Tummaruk P, Tantilertcharoen R Abstract The present study investigated the seroprevalence of porcine reproductive and respiratory syndrome virus, Aujeszky's disease virus (ADV), and porcine parvovirus (PPV) in replacement gilts from selected five swine herds in Thailand. The study consisted of three parts. First, a retrospective data analysis on the seroprevalence of porcine reproductive and respiratory syndrome virus (PRRSV) and ADV glycoprotein I (gI) in gilts, sows, boars, nursery, and fattening pigs in five herds (n = 7,030). Second, a cross-sectional study on seroprevalence of PRRSV, ADV, and PPV (n = 200) in replacement gilts. Last, the seroprevalence of PRRSV, ADV, and PPV in gilts culled due to reproductive failure (n = 166). Across the herds, the serop... Adv Data journals http://www.medworm.com/rss/comments.php?id=5409345 Wed, 09 Nov 2011 05:00:00 +0100 5409345 http://www.medworm.com/index.php?rid=5375058&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21982317%26dopt%3DAbstract CONCLUSIONS: These data support an important role for SR-mediated uptake of OxLDL in the pathogenesis of atherosclerosis and demonstrate that oxidation-specific antibodies reduce the progression of atherosclerosis, suggesting their potential in treating cardiovascular disease in humans. PMID: 21982317 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5375058 Tue, 11 Oct 2011 04:00:00 +0100 5375058 http://www.medworm.com/index.php?rid=5293281&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21974147%26dopt%3DAbstract Authors: Brown DA, Aronov B, Bachand C Abstract Analytical and experimental results are presented for unidirectional broadband multimode piezoelectric acoustic transducers utilizing axisymmetric vibrations of spherical transducers. The analysis covers the acoustic radiation and reception by including the acoustic impedance's and diffraction coefficients for transducers with conformal baffles. The energy method is used to obtain equivalent parameters for a multi-contour electromechanical circuit representation of the transducer and to calculate performance. Experimental data obtained are in good agreement with analytical results. PMID: 21974147 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5293281 Sat, 01 Oct 2011 04:00:00 +0100 5293281 http://www.medworm.com/index.php?rid=5293282&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21962483%26dopt%3DAbstract Authors: Hewitt J, Leonard M, Greening GE, Lewis GD Abstract Human adenovirus (AdV and AdV species F), enterovirus (EV) and norovirus (NoV) concentrations entering wastewater treatment plants (WWTP) serving different-sized communities, and effectiveness of different treatment processes in reducing concentrations were established. Data was combined to create a characteristic and unique descriptor of the individual viral composition and termed as the sample virus profile. Virus profiles were generally independent of population size and treatment process (moving bed biofilm reactors, activated sludge, waste stabilisation ponds). AdV and EV concentrations in wastewater were more variable in small (<4000) and medium-sized (10,000-64,000) WWTP than in large-sized (>130,000 inhabita... Adv Data journals http://www.medworm.com/rss/comments.php?id=5293282 Mon, 19 Sep 2011 04:00:00 +0100 5293282 http://www.medworm.com/index.php?rid=5214747&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21907613%26dopt%3DAbstract CONCLUSIONS: HBoV2 exhibit different epidemiological features from HBoV1 and HBoV3. The data presented herein do not support a causative role for HBoV2 in AGE, despite its high prevalence in stool samples. PMID: 21907613 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5214747 Thu, 08 Sep 2011 04:00:00 +0100 5214747 http://www.medworm.com/index.php?rid=5170239&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21869822%26dopt%3DAbstract Authors: Predina JD, Judy B, Aliperti LA, Fridlender ZG, Blouin A, Kapoor V, Laguna B, Nakagawa H, Rustgi AK, Aguilar L, Aguilar-Cordova E, Albelda SM, Singhal S Abstract Esophageal carcinoma is the most rapidly increasing tumor in the United States and has a dismal 15% 5-year survival. Immunotherapy has been proposed to improve patient outcomes; however, no immunocompetent esophageal carcinoma model exists to date to test this approach. We developed two mouse models of esophageal cancer by inoculating immunocompetent mice with syngeneic esophageal cell lines transformed by cyclin-D1 or mutant HRAS(G12V) and loss of p53. Similar to humans, surgery and adjuvant chemotherapy (cisplatin and 5-fluorouracil) demonstrated limited efficacy. Gene-mediated cyototoxic immunotherapy (adenovir... Adv Data journals http://www.medworm.com/rss/comments.php?id=5170239 Thu, 25 Aug 2011 23:00:00 +0100 5170239 http://www.medworm.com/index.php?rid=5135961&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21816062%26dopt%3DAbstract CONCLUSIONS: Patients treated with LAM plus ADV exhibited significantly greater virological, biochemical and serological responses compared with LAM alone. These data suggest that combination of LAM plus ADV would be a good option for the retreatment of CHB patients with viral relapse after cessation of LAM. PMID: 21816062 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5135961 Wed, 03 Aug 2011 23:00:00 +0100 5135961 http://www.medworm.com/index.php?rid=5135963&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21806648%26dopt%3DAbstract Conclusions  In patients with suboptimal response to adefovir, complete viral suppression and biochemical response can be achieved in the majority by 12 months after switching to entecavir, including patients with prior exposure to lamivudine and those with adefovir resistance. PMID: 21806648 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5135963 Sun, 31 Jul 2011 23:00:00 +0100 5135963 http://www.medworm.com/index.php?rid=5087280&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21776026%26dopt%3DAbstract This study supports our previous findings that local adenovirus and plasmid/liposome-mediated VEGF-A GT is safe and well-tolerated treatment in elderly patients with cardiovascular diseases.Gene Therapy advance online publication, 21 July 2011; doi:10.1038/gt.2011.109. PMID: 21776026 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5087280 Wed, 20 Jul 2011 23:00:00 +0100 5087280 http://www.medworm.com/index.php?rid=5087278&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21777281%26dopt%3DAbstract Conclusions Renal impairment in long-term ADV users was relatively frequent, but serious renal toxicity was rare and all cases were safely managed. Careful monitoring of renal function is required, especially in older patients. PMID: 21777281 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5087278 Tue, 19 Jul 2011 23:00:00 +0100 5087278 http://www.medworm.com/index.php?rid=5087275&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21778896%26dopt%3DAbstract CONCLUSIONS: Although the majority of 109 treatment-experienced patients had prior treatment failure, high rates of CVS were rapidly achieved and did not significantly differ between indications of AVR and PR or between ETV-based and TDF-based regimens. PMID: 21778896 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=5087275 Tue, 19 Jul 2011 23:00:00 +0100 5087275 http://www.medworm.com/index.php?rid=5087247&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21780119%26dopt%3DAbstract Authors: Auge KB, Blake-Haskins AW, Devine S, Rizvi S, Li YM, Hesselberg M, Orvisky E, Affleck RP, Spitznagel TM, Perkins MD Silicone oil is often used to decrease glide forces in prefilled syringes and cartridges, common primary container closures for biopharmaceutical products. Silicone oil has been linked to inducing protein aggregation (Diabet Med 1989;6:278; Diabet Care 1987;10:786-790), leading to patient safety and immunogenicity concerns. Because of the silicone oil application process (Biotech Adv 2007;25:318-324), silicone oil levels tend to vary between individual container closures. Various silicone oil levels were applied to a container closure prior to filling and lyophilization of an albumin and interferon alfa-2b fusion protein (albinterferon alfa-2b). Data demonstrated... Adv Data journals http://www.medworm.com/rss/comments.php?id=5087247 Tue, 19 Jul 2011 23:00:00 +0100 5087247 http://www.medworm.com/index.php?rid=5037480&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21414228%26dopt%3DAbstract In this study, a novel adenovirus was isolated from a colony of cynomolgus macaques (Macaca fascicularis) and subcultured in VERO cells. Its complete genome was purified and a region encompassing the hexon gene, the protease gene, the DNA binding protein (DBP) and the 100 kDa protein was amplified by PCR and sequenced by primer walking. Sequence analysis of these four genes showed that the new isolate had 80% identity to other primate adenoviruses and lacked recombination events. The study of the evolutionary relationships of this new monkey AdV based on the combined sequences of the four genes supported a close relationship to SAdV-3 and SAdV-6, lineages isolated from Rhesus monkeys. The clade formed by these three types is separated from the remaining clades and establishes a novel branc... Adv Data journals http://www.medworm.com/rss/comments.php?id=5037480 Tue, 19 Jul 2011 10:15:13 +0100 5037480 http://www.medworm.com/index.php?rid=5037479&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21430092%26dopt%3DAbstract In this study, we report the complete 45667 bp genome sequence of FAdV-4 of species FAdV-C. Assessment of the protein-coding potential of FAdV-4 was carried out with the Bio-Dictionary-based Gene Finder together with an evaluation of sequence conservation among species FAdV-A and FAdV-D. On this basis, 46 potentially protein-coding ORFs were identified. Of these, 33 and 13 ORFs were assigned high and low protein-coding potential, respectively. Homologues of the ancestral adenoviral genes were, with few exceptions, assigned high protein-coding potential. ORFs that were unique to the FAdVs were differentiated into high and low protein-coding potential groups. Notable putative genes with high protein-coding capacity included the previously unreported fiber 1, hypothetical 10.3K and hypothetic... Adv Data journals http://www.medworm.com/rss/comments.php?id=5037479 Tue, 31 May 2011 23:00:00 +0100 5037479 http://www.medworm.com/index.php?rid=4894274&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21622778%26dopt%3DAbstract We examined DNA extracted from bovine and other animal waste samples collected in Wisconsin for atadenoviruses and mastadenoviruses using novel, broad-spectrum PCR primer sets. BAdV were detected in 13% of cattle fecal samples, 90% of cattle urine samples and 100% of cattle manure samples; forty-four percent of BAdV-positive samples contained both Atadenovirus and Mastadenovirus DNA. Additionally, BAdV were detected in soil and runoff water from a cattle feedlot and residential well water. Overall, we detected eight of 11 prototype BAdV, plus bovine, rabbit and porcine mastadenoviruses that diverged significantly from previously reported genotypes. Prevalent BAdV shedding by cattle supports targeting AdV broadly as indicators of the presence of fecal contamination in aqueous environments. ... Adv Data journals http://www.medworm.com/rss/comments.php?id=4894274 Thu, 26 May 2011 23:00:00 +0100 4894274 http://www.medworm.com/index.php?rid=4894275&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21618552%26dopt%3DAbstract Authors: Zhang S, Chen TH, Wang J, Dong C, Pan J, Moe C, Chen W, Yang L, Wang X, Tang H, Li X, Liu P Rotavirus (RV), norovirus (NoV), and adenovirus (AdV) have been reported as the common viral pathogens of acute gastroenteritis in children. To determine the prevalence of RV, NoV, and AdV infections among hospitalized children with and without symptoms of acute gastroenteritis, fecal specimens, and data on clinical symptoms were collected from 201 children with diarrhea and 53 children without diarrhea admitted to the Xi'an Children's Hospital in Xi'an, China between March 2009 and May 2010. RV, NoV, and AdV were identified in 68.7% (138/201), 20.4% (41/201), and 5.0% (10/201), respectively, of children with diarrhea. These three viruses were also detected in 13.2% (7/53), 35.9% (19/53... Adv Data journals http://www.medworm.com/rss/comments.php?id=4894275 Wed, 25 May 2011 23:00:00 +0100 4894275 http://www.medworm.com/index.php?rid=4795496&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21533115%26dopt%3DAbstract This study aimed to determine the viral and atypical bacterial causes of different severities and clinical manifestations of ARI in preschool children from low-income families in North-East Brazil. PMID: 21533115 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=4795496 Sat, 07 May 2011 17:30:03 +0100 4795496 http://www.medworm.com/index.php?rid=4742998&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21509825%26dopt%3DAbstract Authors: Yu WJ, Chae SH, Lee SY, Duong DL, Lee YH PMID: 21509825 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=4742998 Sat, 23 Apr 2011 17:00:06 +0100 4742998 http://www.medworm.com/index.php?rid=4630792&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21415527%26dopt%3DAbstract Authors: Gao H, Liu L, Qu ZY, Wei FX, Wang SQ, Chen G, Qin L, Jiang FY, Wang YC, Shang L, Gao CY Radix Lithosperm eyrthrorhizon is a common prescription compound in traditional Chinese medicine. Shikonin is a major component of Radix Lithospermi and has various biological activities. We have investigated the inhibitory effect of shikonin on the growth of adenovirus type 3 (AdV3) in vitro. The antiviral function of shikonin against AdV3 and its virus inhibition ratio were detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method (MTT). The expression of hexon protein in AdV3 was determined by immunofluorescence assay using laser scanning confocal microscopy (LSCM) and Western blot analysis. In addition, the rate of apoptosis in cells infected by AdV3 was determined... Adv Data journals http://www.medworm.com/rss/comments.php?id=4630792 Fri, 25 Mar 2011 01:45:03 +0100 4630792 http://www.medworm.com/index.php?rid=4566998&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21374657%26dopt%3DAbstract Conclusion: No nucleoside-naive or nucleoside-experienced patient developed HBV pol/RT mutations associated with TDF resistance after up to 144 weeks of exposure to TDF monotherapy. (HEPATOLOGY 2010). PMID: 21374657 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=4566998 Tue, 01 Mar 2011 00:00:00 +0100 4566998 http://www.medworm.com/index.php?rid=4566999&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21347651%26dopt%3DAbstract Authors: Lee H, Hann HW, Yang JH, Fawcett J Chronic viral hepatitis B and C infection is three to five times more frequent than HIV in the USA, and chronically infected people are at risk for long-term sequelae including cirrhosis, liver decomposition, and hepatocellular carcinoma (Institute of Medicine, 2010). Socio-cultural factors are central to the way an individual constructs hepatitis B virus (HBV) infection, perceives it as serious health problem, and moves on to appropriate health behavior (Lee et al., J Canc Educ 25:337-342, 2010; Kim, J Health Care Poor Underserved 5:170-182, 2004; Lee et al., Asian Nurs Res 1:1-11, 2007; Wu et al, Asian Pac J Cancer Prev 8(1):127-234, 2007; Yang et al., J Korean Academy Nurs 40:662-675, 2010). The purpose of this study was to seek "real worl... Adv Data journals http://www.medworm.com/rss/comments.php?id=4566999 Thu, 24 Feb 2011 00:00:00 +0100 4566999 http://www.medworm.com/index.php?rid=4512798&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21327918%26dopt%3DAbstract CONCLUSIONS: Failure to monotherapy in a community clinical setting is due to both antiviral resistance and patient nonadherence. Medication nonadherence is likely to be a more important contributor to treatment failure than antiviral resistance, especially with new anti-HBV agents such as ETV and tenofovir. PMID: 21327918 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=4512798 Thu, 17 Feb 2011 00:00:00 +0100 4512798 http://www.medworm.com/index.php?rid=4455620&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21294799%26dopt%3DAbstract This study is the first to examine genetic relationships among seven species of the complex at nuclear markers (nine microsatellite loci and one protein-coding gene). Clones belonging to the seven species of the Daphnia pulex complex were characterized at the mitochondrial NADH dehydrogenase (ND5) gene and at the Lactate dehydrogenase (LDH) locus. K-means, principal coordinate analyses and phylogenetic network analyses on the microsatellite data all separated European D. pulicaria, D. tenebrosa, North American D. pulex, D. pulicaria and their hybrids into distinct clusters. The hybrid cluster was composed of diploid and polyploid hybrids with D. pulex mitochondria and some clones with D. pulicaria mitochondria. By contrast, the phylogeny of the D. pulex complex using Rab4 was not we... Adv Data journals http://www.medworm.com/rss/comments.php?id=4455620 Sat, 05 Feb 2011 00:00:00 +0100 4455620 http://www.medworm.com/index.php?rid=4389140&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21209115%26dopt%3DAbstract Authors: Moyer CL, Wiethoff CM, Maier O, Smith JG, Nemerow GR The identification of the adenovirus (AdV) protein that mediates endosome penetration during infection has remained elusive. Several lines of evidence from previous studies suggest that the membrane lytic factor of AdV is the internal capsid protein VI. While these earlier results imply a role for VI in endosome disruption, direct evidence during cell entry has not been demonstrated. To acquire more definitive proof, we engineered random mutations in a critical N-terminal amphipathic α-helix of VI in an attempt to generate AdV mutants that lack efficient membrane penetration and infection. Random mutagenesis within the context of the AdV genome was achieved via the development of a novel technique that incorporates both err... Adv Data journals http://www.medworm.com/rss/comments.php?id=4389140 Wed, 05 Jan 2011 00:00:00 +0100 4389140 http://www.medworm.com/index.php?rid=4389139&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21253304%26dopt%3DAbstract Authors: Shin SR, Koh KC, Gwak GY, Choi MS, Lee JH, Paik SW, Yoo BC Adefovir (ADV) is the preferred drug for treating lamivudine (LAM)-resistant hepatitis B. However, not all patients who face virologic breakthrough during LAM treatment respond to ADV. The aim of this study was to determine the factors associated with efficacy of ADV in LAM-resistant hepatitis B patients. PMID: 21253304 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=4389139 Wed, 01 Dec 2010 00:00:00 +0100 4389139 http://www.medworm.com/index.php?rid=4300765&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21168635%26dopt%3DAbstract Authors: Watcharananan SP, Junchotikul P, Srichanrusmi C, Chanchompoo P, Mavichak V, Kantachuvessiri S, Chantratita W Data on the epidemiology and route of acquisition of adenovirus (ADV) infection after kidney transplantation are limited. From April 2007 to March 2010, there were 17 cases of ADV infection: namely, 2 from April to December 2007; 8 from January to December 2008; 4 from January to December 2009; and 3 from January to March 2010. Most cases occurred in October and November (n = 8; 47.1%), followed by February to April (n = 6; 35.3%) and July (n = 3; 17.6%). PMID: 21168635 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=4300765 Wed, 01 Dec 2010 00:00:00 +0100 4300765 http://www.medworm.com/index.php?rid=4244656&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21123530%26dopt%3DAbstract Authors: Dey RS, Ghosh S, Chawla-Sarkar M, Panchalingam S, Nataro JP, Sur D, Manna B, Ramamurthy T Human adenovirus of subgenus F (AdV F) are the most common strains detected in the acute gastroenteritis cases in developing countries. Subgenus F is represented by adenovirus serotype 40 and 41. Most of the reports described predominance of AdV-41 in the acute gastroenteritis cases. To gain insight into the epidemiology and genetic variation of AdV-41 strains, we analyzed 1053 stool specimens of children with diarrhea. Among them, 42 (4.0%) and 56 (5.3%) were positive for enteric adenovirus 40/41 by ELISA and PCR, respectively. In 1305 asymptomatic children, 9 (0.7%) and 22 (1.7%) samples were positive for enteric adenovirus 40/40 by ELISA and PCR, respectively. Agewise distribution reve... Adv Data journals http://www.medworm.com/rss/comments.php?id=4244656 Wed, 01 Dec 2010 00:00:00 +0100 4244656 http://www.medworm.com/index.php?rid=4244657&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21122880%26dopt%3DAbstract Authors: Fettweis M, Baeye M, Francken F, Lauwaert B, Van den Eynde D, Van Lancker V, Martens C, Michielsen T The impact of continuous disposal of fine-grained sediments from maintenance dredging works on the suspended particulate matter concentration in a shallow nearshore turbidity maximum was investigated during dredging experiment (port of Zeebrugge, southern North Sea). Before, during and after the experiment monitoring of SPM concentration using OBS and ADV altimetry was carried out at a location 5km west of the disposal site. A statistical analysis, based on the concept of populations and sub-sampling, was applied to evaluate the effect. The data revealed that the SPM concentration near the bed was on average more than two times higher during the dredging experiment. The dispose... Adv Data journals http://www.medworm.com/rss/comments.php?id=4244657 Mon, 29 Nov 2010 00:00:00 +0100 4244657 http://www.medworm.com/index.php?rid=4180647&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20585634%26dopt%3DAbstract Authors: Smith JG, Silvestry M, Lindert S, Lu W, Nemerow GR, Stewart PL Defensins are effectors of the innate immune response with potent antibacterial activity. Their role in antiviral immunity, particularly for non-enveloped viruses, is poorly understood. We recently found that human alpha-defensins inhibit human adenovirus (HAdV) by preventing virus uncoating and release of the endosomalytic protein VI during cell entry. Consequently, AdV remains trapped in the endosomal/lysosomal pathway rather than trafficking to the nucleus. To gain insight into the mechanism of defensin-mediated neutralization, we analyzed the specificity of the AdV-defensin interaction. Sensitivity to alpha-defensin neutralization is a common feature of HAdV species A, B1, B2, C, and E, whereas species D and F ... Adv Data journals http://www.medworm.com/rss/comments.php?id=4180647 Fri, 19 Nov 2010 09:35:02 +0100 4180647 http://www.medworm.com/index.php?rid=3908569&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20740566%26dopt%3DAbstract Authors: Mezei M Simulaid performs a large number of simulation-related tasks: interconversion and modification of structure and trajectory files, optimization of orientation, and a large variety of analysis functions. The program can handle structures in PDB (Berman et al., Nucleic Acids Res 2000, 28, 235), Charmm (Brooks et al., J Comput Chem 4, 187) CRD, Amber (Case et al.), Macromodel (Mohamadi et al., J Comput Chem 1990, 11, 440), Gromos/Gromacs (Hess et al.), InsightII (InsightII. Accelrys Inc.: San Diego, 2005), Grasp (Nicholls et al., Proteins: Struct Funct Genet 1991, 11, 281) .crg, Tripos (Tripos International, S. H. R., St. Louis, MO) .mol2 (input only), and in the MMC (Mezei, M.; MMC: Monte Carlo program for molecular assemblies. Available at: http://inka.mssm.edu/ approxim... Adv Data journals http://www.medworm.com/rss/comments.php?id=3908569 Sat, 28 Aug 2010 04:03:09 +0100 3908569 http://www.medworm.com/index.php?rid=3741304&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20388199%26dopt%3DAbstract CONCLUSION: The generated anti-TLR2 scFv intrabody inhibits specifically and very efficiently TLR2 ligand-driven cell activation in vitro and ex vivo. This indicates a therapeutic potential of alphaT2ib in microbial or viral infections. PMID: 20388199 [PubMed - indexed for MEDLINE] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=3741304 Sat, 10 Jul 2010 23:45:02 +0100 3741304 http://www.medworm.com/index.php?rid=3718994&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587148%26dopt%3DAbstract In this study, we assessed the gene transfer efficiency of SeV vector in the floating state to pancreatic stem cells. The efficiency of gene transfer was much higher at all time points and at all concentration in the floating state versus in the adhesion state. In addition, the pancreatic stem cells transfected with SeV in the floating state maintained their differentiation ability. These data suggest that SeV transfection to pancreatic stem cells in the floating state may be useful in gene transfer technology. PMID: 20587148 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=3718994 Mon, 28 Jun 2010 23:00:00 +0100 3718994 http://www.medworm.com/index.php?rid=3672414&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20538514%26dopt%3DAbstract CONCLUSION: A positive evolution is clearly observable in European primary care physicians' use of eHealth, mainly with regard to online medical information searches, use of electronic health care records, and (to a lesser extent) electronic transfers of patient data. The international comparative profiling of European GPs' eHealth usage patterns contributes to more efficient and continually adapted promotion strategies, aimed at fostering the diffusion of eHealth applications among medical professionals of the analyzed EU-15 countries. PMID: 20538514 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=3672414 Mon, 07 Jun 2010 23:00:00 +0100 3672414 http://www.medworm.com/index.php?rid=3623518&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20515375%26dopt%3DAbstract Authors: Schauber S, Nouns ZM The Berlin Progress Test has grown to a cooperation of 13 universities. Recently, comparisons between the participating schools became an area of high interest. Muijtjens et al. [Muijtjens AM, Schuwirth LWT, Cohen-Schotanus J, Thoben AJNM, van der Vleuten CPM. 2008a. Benchmarking by cross-institutional comparison of student achievement in a progress test. Med Educ 41(1):82-88; Muijtjens AM, Schuwirth LWT, Cohen-Schotanus J, van der Vleuten CPM. 2008b. Differences in knowledge development exposed by multi-curricular progress test data. Adv Health Sci Educ 13:593-605] proposed a method for cross-institutional benchmarking based on progress test data. Progress testing has some major advantages as it delivers longitudinal information about student's growth of ... Adv Data journals http://www.medworm.com/rss/comments.php?id=3623518 Thu, 03 Jun 2010 13:48:02 +0100 3623518 http://www.medworm.com/index.php?rid=3448344&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20089640%26dopt%3DAbstract In this study, a novel bat adenovirus (AdV) (BtAdV-TJM) was isolated from bat fecal samples by using a bat primary kidney cell line. Infection studies indicated that most animal and human cell lines are susceptible to BtAdV-TJM, suggesting a possible wide host range. Genome analysis revealed 30 putative genes encoding proteins homologous to their counterparts in most known AdVs. Phylogenetic analysis placed BtAdV-TJM within the genus Mastadenovirus, most closely related to tree shrew and canine AdVs. PCR analysis of 350 bat fecal samples, collected from 19 species in five Chinese provinces during 2007 and 2008, indicated that 28 (or 8%) samples were positive for AdVs. The samples were from five bat species, Hipposideros armiger, Myotis horsfieldii, M. ricketti, Myotis spp., and Scotophilus... Adv Data journals http://www.medworm.com/rss/comments.php?id=3448344 Wed, 31 Mar 2010 23:00:00 +0100 3448344 http://www.medworm.com/index.php?rid=3379273&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20228849%26dopt%3DAbstract Authors: Verdeguer A, de Heredia CD, González M, Martínez AM, Fernández-Navarro JM, Pérez-Hurtado JM, Badell I, Gómez P, González ME, Muñoz A, Díaz MA We studied surveillance, incidence and outcome of viral infections in children undergoing allogeneic hematopoietic cell transplantation (HCT) in the main pediatric transplant units in Spain. We prospectively collected data from first year post-HCT in every consecutive allogeneic HCT performed during 3 years (N=215): first HCT=188 and second HCT=27; median age=6.6 years (0.1-20.7). Most patients had acute leukemia (N=137) and 135 recipients (63%) were CMV seropositive. A total of 46 patients underwent cord blood transplant, 133 patients underwent HCT from alternative donors (62%) and 101 patients re... Adv Data journals http://www.medworm.com/rss/comments.php?id=3379273 Mon, 15 Mar 2010 00:00:00 +0100 3379273 http://www.medworm.com/index.php?rid=3327777&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20190624%26dopt%3DAbstract CONCLUSION.: Our results suggest that targeted retrograde BDNF gene delivery suppresses apoptosis of neurons and oligodendrocytes in the injured rat spinal cord. PMID: 20190624 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=3327777 Mon, 01 Mar 2010 00:00:00 +0100 3327777 http://www.medworm.com/index.php?rid=2982204&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19899593%26dopt%3DAbstract Authors: Panasik A, Pancer K Human metapneumovirus (hMPV) is a recently discovered respiratory virus. hMPV, the second after respiratory syncytial virus (RSV), is leading cause of upper and lower respiratory tract infections mainly in infants and children. hMPV infections have been reported in many countries in all the world, in patients in every age and gender, but children under 5 years are most likely to be susceptible to infections caused by hMPV. The frequency of hMPV infections require hospitalization in this group is 5-10%. Late winter and early spring is the epidemic peak of hMPV infections in a lot of countries. The similar time of hMPV infections and another respiratory viruses is leading to appear coinfections. Many data reported higher frequency of double coinfections (RSV ... Adv Data journals http://www.medworm.com/rss/comments.php?id=2982204 Thu, 12 Nov 2009 13:04:03 +0100 2982204 http://www.medworm.com/index.php?rid=2881420&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19814305%26dopt%3DAbstract Authors: Shimura T, Ochi H, Watanabe Y, Hattori T The research is being conducted to realize communication with a long cruising AUV in the deep ocean using time reversal. We have proposed the method of combining time reversal and adaptive equalization. In our previous at-sea experiments, the performance of time-reversal communication was confirmed at the range of 10-100 km with a virtual array. In our latest sea-trial, experiments of passive time-reversal communication were executed at the range of 300 km with a real receiver array. As a probe signal, chirp pulses and M-sequence pulses were used. The data transmission speed was 50 and 100 bps. The source was suspended from the research vessel and the 20 channel receiver array was moored. Thus, Doppler effect was induced due to the ship... Adv Data journals http://www.medworm.com/rss/comments.php?id=2881420 Wed, 30 Sep 2009 23:00:00 +0100 2881420 http://www.medworm.com/index.php?rid=2821232&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19626610%26dopt%3DAbstract In this study, stool specimens from 31 patients with hematological disorders (25 transplanted and 6 non-transplanted) were examined prospectively to determine whether the novel polyomaviruses KIV and WUV reactivated and were excreted in the gastrointestinal tract. Reactivation was correlated with the appearance of gastrointestinal and respiratory symptoms. Of the 31 patients examined, KIV and WUV were detected in 13 transplanted patients as single infection or in combination with BKV, cytomegalovirus (CMV), and adenovirus (Adv). Because of frequent co-infections, a clear correlation between novel polyomaviruses and clinical symptoms could not be established. There was no correlation between demographic variables and detection of KIV and WUV. Phylogenetic analysis of the small t-antigen gen... Adv Data journals http://www.medworm.com/rss/comments.php?id=2821232 Mon, 31 Aug 2009 23:00:00 +0100 2821232 http://www.medworm.com/index.php?rid=2734842&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19705175%26dopt%3DAbstract Authors: De Vos N, Vankeerberghen A, Vaeyens F, Van Vaerenbergh K, Boel A, De Beenhouwer H Since the discovery of human bocavirus (hBoV), the virus has been detected worldwide in respiratory tract samples from young children by various polymerase chain reaction (PCR) assays and real-time PCRs (Q-PCR). Until now, no data have been reported on the presence of hBoV in Belgium and the detection of hBoV in a multiplex Q-PCR setting has not been described. The aim of this study was to develop a fast and reliable multiplex Q-PCR for the simultaneous detection of hBoV DNA and adenovirus (AdV) DNA. During the winter of 2004-2005, 445 nasopharyngeal aspirates (NPAs) were analysed from 404 Belgian children up to 5 years old with acute respiratory tract infections (ARTIs). (Co)infections with hBoV... Adv Data journals http://www.medworm.com/rss/comments.php?id=2734842 Mon, 24 Aug 2009 23:00:00 +0100 2734842 http://www.medworm.com/index.php?rid=2662837&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19643265%26dopt%3DAbstract CONCLUSION: The absence of viral genomes in laryngeal carcinomas as in the other cases studied suggests the existence of other factors that play a more important role than viral infection in the carcinogenesis of these lesions. PMID: 19643265 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=2662837 Fri, 31 Jul 2009 23:00:00 +0100 2662837 http://www.medworm.com/index.php?rid=2614541&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19607759%26dopt%3DAbstract CONCLUSIONS: Both ADV and PEG-alpha are beneficial for patients with CHB in terms of suppressing viral load, reducing liver damage-associated biochemical activity, inducing HBeAg seroconversion, and reducing liver fibrosis and necroinflammation. The effects of long-term treatment with ADV are generally durable, with relatively low rates of resistance. In most cases, cost-effectiveness estimates were within acceptable ranges. Further research should assess the clinical effectiveness and cost-effectiveness of newer antiviral agents in relation to existing drugs, including the role of initiating treatment with combination therapy. PMID: 19607759 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=2614541 Tue, 30 Jun 2009 23:00:00 +0100 2614541 http://www.medworm.com/index.php?rid=2544605&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19467282%26dopt%3DAbstract Authors: Eto Y, Yoshioka Y, Asavatanabodee R, Kida S, Maeda M, Mukai Y, Mizuguchi H, Kawasaki K, Okada N, Nakagawa S Adenovirus vectors (Advs) are widely used for basic and clinical research because of their high transduction efficiency. However, they are poorly transduced into cells lacking the primary adenovirus receptor, the coxsackievirus and adenovirus receptor (CAR). Here, we generated Adv conjugated with cell-penetrating peptides (CPPs), such as Tat, octaarginine (R8) or proline-rich (Pro) peptides, and compared the transduction properties of these constructs. We constructed the Advs conjugated to the CPPs (CPP-Adv) by chemical conjugation. The CPP-conjugated Advs created with optimal modification ratios led to gene expression 1-2log orders higher than unmodified Adv in CAR-nega... Adv Data journals http://www.medworm.com/rss/comments.php?id=2544605 Fri, 22 May 2009 23:00:00 +0100 2544605 http://www.medworm.com/index.php?rid=2544604&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19517525%26dopt%3DAbstract Conclusion: ADV is an independent predictor for significant deterioration of renal function. Patients on ADV should be monitored, especially patients who are older, have baseline renal insufficiency, or have hypertension and/or diabetes mellitus. (HEPATOLOGY 2009.). PMID: 19517525 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=2544604 Thu, 23 Apr 2009 23:00:00 +0100 2544604 http://www.medworm.com/index.php?rid=2322240&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19342807%26dopt%3DAbstract Authors: Madhani JT, Kelson NA, Brown RJ Flow through a gross pollutant trap (GPT) with fully blocked screens is investigated experimentally and theoretically using computational fluid dynamics (CFD). Due to the wide range of possible flow regimes, an experimental approach is developed which uses a downstream weir arrangement to control the nature of the flow and the variation in free surface height. To determine the overall flow structure, measurements are taken at a fixed depth throughout the trap with an Acoustic Doppler Velocimeter (ADV), including velocity profile data across three cross sections of the GPT suitable for more detailed comparison with simulations. Observations of the near-wall flow features at the free surface are also taken, due to their likely importance for under... Adv Data journals http://www.medworm.com/rss/comments.php?id=2322240 Sat, 11 Apr 2009 09:27:22 +0100 2322240 http://www.medworm.com/index.php?rid=2322237&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19351540%26dopt%3DAbstract In this study, we investigated whether lowering of ADMA by overexpression of dimethylarginine dimethylaminohydrolase (DDAH), a main enzyme that degrades ADMA, could ameliorate glomerular capillary loss and sclerosis in a rat model of CKD. Four weeks after 5/6 subtotal nephrectomy (Nx), animals were given tail vein injections with recombinant adenovirus vector encoding DDAH-I (Adv-DDAH) or control vector expressing bacterial b-galactosidase (Adv-LZ), or orally administered with 20mg/kg/day of hydralazine (Hyz) which served as a blood pressure control model. KEY FINDINGS: Plasma levels of ADMA were associated with decreased number of glomerular capillaries as well as severity of glomerular sclerosis in Nx rats. These glomerular changes progressed in Adv-LZ- or Hyz-treated Nx rats, while they... Adv Data journals http://www.medworm.com/rss/comments.php?id=2322237 Sat, 04 Apr 2009 04:00:00 +0100 2322237 http://www.medworm.com/index.php?rid=2215028&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19237664%26dopt%3DAbstract Conclusions-Our data show for the first time the high efficacy of an RNAi therapeutic strategy in a cardiac disease. PMID: 19237664 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=2215028 Mon, 23 Feb 2009 05:00:00 +0100 2215028 http://www.medworm.com/index.php?rid=2198664&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19222742%26dopt%3DAbstract Authors: Idilman R, Kaymakoglu S, Oguz Onder F, Ahishali E, Bektas M, Cinar K, Pınarbasi B, Karayalcin S, Badur S, Cakaloglu Y, Mithat Bozdayi A, Bozkaya H, Okten A, Yurdaydin C Summary. The aims of the study were to investigate the efficacy of rescue therapy with lamivudine (LAM) and adefovir (ADV) combination for 6 months followed by ADV monotherapy in lamivudine-resistant chronic hepatitis B (LAM-R CHB) patients, and to analyze the frequency of ADV resistance mutant development in such patients. A total of 170 consecutive LAM-R CHB patients (male/female: 130/40, mean age: 42.9 +/- 13.4 years) with viral breakthrough under LAM therapy were analyzed. A total of 68 had HBeAg-positive. Patients received rescue therapy with LAM [100 mg (qd)]+ADV [10 mg (qd)] for 6 months after whic... Adv Data journals http://www.medworm.com/rss/comments.php?id=2198664 Thu, 12 Feb 2009 05:00:00 +0100 2198664 http://www.medworm.com/index.php?rid=2176882&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19199366%26dopt%3DAbstract Authors: Ferreira TB, Perdigão R, Silva AC, Zhang C, Aunins JG, Carrondo MJ, Alves PM As the market requirements for adenovirus vectors (AdV) increase, the maximisation of the virus titer per culture volume per unit time is a key requirement. However, despite the fact that 293 cells can grow up to 8 x 10(6) cell/mL in simple batch mode operations, for optimal AdV infection a maximum cell density of 1 x 10(6) cell/mL at infection time has usually been utilized due to the so called "cell density effect". In addition, AdV titer appears to be dependent upon cell cycle phase at the time of infection. To evaluate the dependence of AdV production upon cell cycle phase, 293 cells were chemically synchronised at each phase of the cell cycle; a 2.6-fold increase on AdV cell specific titer w... Adv Data journals http://www.medworm.com/rss/comments.php?id=2176882 Fri, 09 Jan 2009 05:00:00 +0100 2176882 http://www.medworm.com/index.php?rid=1967387&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19012779%26dopt%3DAbstract Conclusion. This study provides empirical insight into children's experiences of communication in an inpatient hospital setting. A key recommendation calls for the development of communication assessment strategies to determine the 'ideal' position children would like to occupy, at any given point in time, along the 'visible-ness' continuum. Relevance to practice. This study emphasises the need for all health professionals to embrace the individualism of each child patient with regard to their specific communication needs. PMID: 19012779 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=1967387 Wed, 19 Nov 2008 05:06:38 +0100 1967387 http://www.medworm.com/index.php?rid=1967386&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19012782%26dopt%3DAbstract Conclusions. Dealing with perceived chaos is hard in reality, but capturing it is part of the complexity of qualitative enquiry. The context is interdependent with children's perceived reality, because they communicate with others through their environment. Relevance to practice. This paper gives researchers an insight into the tensions of operating out in the field and helps raise the importance of the environmental 'chaos' in revealing significant issues relevant to peoples daily lives. Knowing that unexpected chaos is part and parcel of qualitative research, will equip researchers with skills fundamental for balancing the well being of all those involved with the quality of the research process. PMID: 19012782 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=1967386 Wed, 19 Nov 2008 05:06:34 +0100 1967386 http://www.medworm.com/index.php?rid=1967388&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19010710%26dopt%3DAbstract Authors: Lunardi G, Galati S, Tropepi D, Moschella V, Brusa L, Pierantozzi M, Stefani A, Rossi S, Fornai F, Fedele E, Stanzione P, Hainsworth AH, Pisani A To assess possible differences in dopamine metabolism that could parallel disease progression in Parkinson's disease (PD), we measured dopamine (DA) and its metabolites in the cerebrospinal fluid (CSF) in PD patients at different stages of disease: de novo (DEN), advanced not showing dyskinesias (ADV), and advanced with dyskinesias (DYS). DA, homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly higher in DEN patients compared with other groups. A negative exponential correlation related DA level and disease duration. The HVA/DA ratio was significantly higher in the ADV and DYS group than that found in DEN... Adv Data journals http://www.medworm.com/rss/comments.php?id=1967388 Fri, 14 Nov 2008 05:00:00 +0100 1967388 http://www.medworm.com/index.php?rid=1899745&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18930744%26dopt%3DAbstract In this study, we attempted to generate novel Tat-Advs (Advs conjugated with the HIV Tat-derived peptide, a protein-transduction domain (PTD)) to broaden Adv tropism and enhance transduction efficiency. MAIN METHODS: We constructed Tat-Advs by chemically conjugating Tat peptide to the surface-exposed lysine residues on Advs. We compared the gene transfer activity of Tat-Advs with that of unmodified Advs by measuring the luciferase expression in several types of cell lines. KEY FINDINGS: Tat-Advs showed gene expression 1 to 3 log orders higher than unmodified Advs in CAR-negative adherent cells and blood cells, which are refractory to conventional Advs. The inhibition of Tat-Adv-mediated gene expression by heparin and macropinocytosis inhibitor confirms that binding of Tat-Adv to cellular H... Adv Data journals http://www.medworm.com/rss/comments.php?id=1899745 Sun, 05 Oct 2008 04:00:00 +0100 1899745 http://www.medworm.com/index.php?rid=1832203&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18816503%26dopt%3DAbstract Authors: Beckebaum S, Sotiropoulos GC, Gerken G, Cicinnati VR The ultimate goal of treatment is suppression of viral replication to undetectable HBV-DNA levels prior to and after liver transplantation (LT) to prevent infection of the newly transplanted liver. Most published data are available from therapy with lamivudine (LAM) in pre- and post-transplant HBV patients. Add-on therapy with adefovir dipivoxil (ADV) in pre-transplant LAM-resistant patients has been shown to represent an effective antiviral strategy leading to hepatic recompensation in many cases and, eventually, removal from the waiting list. Newer nucleos(t)ide analogues such as entecavir, tenofovir and telbivudine have shown lower resistance rates than LAM and more antiviral potency in studies in the non-transplant setti... Adv Data journals http://www.medworm.com/rss/comments.php?id=1832203 Wed, 24 Sep 2008 04:00:00 +0100 1832203 http://www.medworm.com/index.php?rid=1805406&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18795900%26dopt%3DAbstract Conclusion: Adefovir dipivoxil provides effective and safe treatment in cirrhotic and elderly patients who failed LAM therapy. PMID: 18795900 [PubMed - as supplied by publisher] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=1805406 Mon, 15 Sep 2008 04:00:00 +0100 1805406 http://www.medworm.com/index.php?rid=1744942&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18723516%26dopt%3DAbstract Authors: Mio K, Ogura T, Mio M, Shimizu H, Hwang TC, Sato C, Sohma Y The cystic fibrosis transmembrane regulator (CFTR) chloride channel is a membrane integral protein that belongs to an ATP-binding cassette superfamily. Mutations in the CFTR gene cause cystic fibrosis (CF) in which salt, water and protein transports are defective in various tissues. Here we have expressed wild-type human CFTR as a FLAG-fused protein in HEK293 cells heterologously, and purified it in three steps: anti-FLAG and wheat germ agglutinin affinity chromatographies and size exclusion chromatography. The stoichiometry of the protein was analyzed using various biochemical approaches, including chemical cross-linking, blue-native PAGE, size exclusion chromatography, and EM observation of antibody decorated CFTR. ... Adv Data journals http://www.medworm.com/rss/comments.php?id=1744942 Fri, 22 Aug 2008 04:00:00 +0100 1744942 http://www.medworm.com/index.php?rid=1676527&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18508893%26dopt%3DAbstract Authors: Pantelic RS, Lockett LJ, Rothnagel R, Hankamer B, Both GW A three-dimensional (3D) cryoelectron microscopy reconstruction of the prototype Atadenovirus (OAdV [an ovine adenovirus isolate]) showing information at a 10.6-A resolution (0.5 Fourier shell correlation) was derived by single-particle analysis. This is the first 3D structure solved for any adenovirus that is not a Mastadenovirus, allowing cross-genus comparisons between structures and the assignment of genus-specific capsid proteins. Viable OAdV mutants that lacked the genus-specific LH3 and p32k proteins in purified virions were also generated. Negatively stained 3D reconstructions of these mutants were used to identify the location of protein LH3 and infer that of p32k within the capsid. The key finding was that LH3... Adv Data journals http://www.medworm.com/rss/comments.php?id=1676527 Fri, 01 Aug 2008 04:00:00 +0100 1676527 http://www.medworm.com/index.php?rid=1667738&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18662730%26dopt%3DAbstract Authors: Yockman JW, Kastenmeier A, Erickson HM, Brumbach JG, Whitten MG, Albanil A, Li DY, Kim SW, Bull DA The number one cause of mortality in the US is cardiovascular related disease. Future predictions do not see a reduction in this rate especially with the continued rise in obesity [P. Poirier, et al., Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss, Arterioscler Thromb Vasc Biol. 26(5), (2006) 968-976.; K. Obunai, S. Jani, G.D. Dangas, Cardiovascular morbidity and mortality of the metabolic syndrome, Med.Clin. North Am., 91(6), (2007) 1169-1184.]. Even so, potential molecular therapeutic targets for cardiac gene delivery are in no short supply thanks to continuing advances in molecular cardiology. However, efficient and safe delivery rem... Adv Data journals http://www.medworm.com/rss/comments.php?id=1667738 Sun, 06 Jul 2008 04:00:00 +0100 1667738 http://www.medworm.com/index.php?rid=1550135&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18578989%26dopt%3DAbstract CONCLUSIONS: Our results suggest that genotype B HBV has a better virological response to ADV therapy in HBeAg-positive chronic hepatitis B patients than that of genotype C. Longer terms of ADV treatment are needed to confirm this conclusion. [Chinese FullText URL http://zhgz.chinajournal.net.cn]. PMID: 18578989 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=1550135 Sun, 01 Jun 2008 04:00:00 +0100 1550135 http://www.medworm.com/index.php?rid=1468713&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18488218%26dopt%3DAbstract Authors: Vujanovic L, Whiteside TL, Potter DM, Chu J, Ferrone S, Butterfield LH Recombinant adenoviral vectors (AdV) are potent vehicles for antigen engineering of dendritic cells (DC). DC engineered with AdV to express full length tumor antigens are capable stimulators of antigen-specific polyclonal CD8+ and CD4+ T cells. To determine the impact of AdV on the HLA class I antigen presentation pathway, we investigated the effects of AdV transduction on antigen processing machinery (APM) components in human DC. Interactions among AdV transduction, maturation, APM regulation and T cell activation were investigated. The phenotype and cytokine profile of DC transduced with AdV was intermediate, between immature (iDC) and matured DC (mDC). Statistically significant increases in expression we... Adv Data journals http://www.medworm.com/rss/comments.php?id=1468713 Sat, 17 May 2008 04:00:00 +0100 1468713 http://www.medworm.com/index.php?rid=1468716&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17909814%26dopt%3DAbstract We present a general framework for such models, and describe three alternate classification schemes. Combining with the species-level model of Aldous and Popovic (Adv Appl Probab 37:1094-1115, 2005), one gets models for higher-order trees, and we initiate analytic study of such models. In particular we derive formulas for the lifetime of genera, for the distribution of number of species per genus, and for the offspring structure of the tree on genera. PMID: 17909814 [PubMed - indexed for MEDLINE] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=1468716 Tue, 01 Apr 2008 04:00:00 +0100 1468716 http://www.medworm.com/index.php?rid=1468715&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18205221%26dopt%3DAbstract In this study, we compared the efficiency of inducing green fluorescent protein (GFP) and HIV-1 gene expression in human monocyte-derived DCs between SeV and adenovirus (AdV). Human monocyte-derived DCs infected with SeV showed the maximum gene expression 24 hr after infection at a multiplicity of infection (MOI) of 2. Although SeV vector showed higher cytopathic effect on DCs than AdV, SeV vector induced maximum gene expression earlier and at much lower MOI. In terms of cell surface phenotype, both SeV and AdV vectors induced DC maturation. DCs infected with SeV as well as AdV elicited HIV-1 specific T-cell responses detected by interferon gamma (IFN-gamma) enzyme-linked immunospot (Elispot). Our data suggest that SeV could be one of the reliable vectors for immuno-genetherapy for HIV-1 i... Adv Data journals http://www.medworm.com/rss/comments.php?id=1468715 Sat, 01 Mar 2008 05:00:00 +0100 1468715 http://www.medworm.com/index.php?rid=1468714&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18243030%26dopt%3DAbstract CONCLUSION: Decision to let the resident operate remains too dependent on senior personal appreciation and does not seem to join a strategy of training. Opinions of surgical training in the operating room is different between residents and seniors. Operating time increases when residents operate but there is no effect on quality of care. These results show again the necessity of a formal teaching and assessment, in a resident program with objectives, collecting every resident's surgery volume. These educational improvements will contribute certainly to the professionalization of residents. PMID: 18243030 [PubMed - indexed for MEDLINE] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=1468714 Fri, 01 Feb 2008 05:00:00 +0100 1468714 http://www.medworm.com/index.php?rid=1234143&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18271366%26dopt%3DAbstract This report compares national estimates for selected health status indicators, health behaviors, health care utilization, health conditions, immunizations, and human immunodeficiency virus (HIV) testing status among selected non-Hispanic Asian adult subgroups. Comparison estimates for the non-Hispanic white, non-Hispanic black, non-Hispanic American Indian or Alaska Native (AIAN), and Hispanic adult populations are also presented. METHODS: The estimates in this report were derived from the Family Core and the Sample Adult Core components of the 2004-2006 National Health Interview Surveys (NHIS), conducted by the Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS). Estimates were generated and comparisons conducted using the SUDAAN statistical package t... Adv Data journals http://www.medworm.com/rss/comments.php?id=1234143 Tue, 22 Jan 2008 05:00:00 +0100 1234143 http://www.medworm.com/index.php?rid=1043180&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18019786%26dopt%3DAbstract This report presents the latest information on the use of electronic medical records in physician offices. Percentages of medical practices and physicians within the practices using electronic medical records (EMR) are presented for 2006 by selected physician and practice characteristics. METHODS: Data from the physician induction interviews of the 2006 National Ambulatory Medical Care Survey (NAMCS) are presented. NAMCS includes a national probability sample of nonfederal office-based physicians who saw patients in an office setting. Sample data were weighted to produce national estimates of physicians. Estimates of medical practices were derived from NAMCS physician data by adjusting the weighting scheme using a multiplicity estimator. RESULTS: In 2006, 29.2 percent of office-based physi... Adv Data journals http://www.medworm.com/rss/comments.php?id=1043180 Fri, 26 Oct 2007 04:00:00 +0100 1043180 http://www.medworm.com/index.php?rid=975882&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17953135%26dopt%3DAbstract CONCLUSION: Fall injuries remain very prevalent among older adults and result in high health care utilization and activity limitations. Rates of fall injuries vary by demographic and health characteristics of older noninstitutionalized adults. PMID: 17953135 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=975882 Fri, 21 Sep 2007 04:00:00 +0100 975882 http://www.medworm.com/index.php?rid=884980&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17874715%26dopt%3DAbstract This study presents baseline data to determine which hospital characteristics are associated with preparedness for terrorism and natural disaster in the areas of emergency response planning and availability of equipment and specialized care units. METHODS: Information from the Bioterrorism and Mass Casualty Preparedness Supplements to the 2003 and 2004 National Hospital Ambulatory Medical Care Surveys was used to provide national estimates of variations in hospital emergency response plans and resources by residency and medical school affiliation, hospital size, ownership, metropolitan statistical area status, and Joint Commission accreditation. Of 874 sampled hospitals with emergency or outpatient departments, 739 responded for an 84.6 percent response rate. Estimates are presented with 9... Adv Data journals http://www.medworm.com/rss/comments.php?id=884980 Mon, 20 Aug 2007 04:00:00 +0100 884980 http://www.medworm.com/index.php?rid=807898&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17702147%26dopt%3DAbstract Authors: Niska RW, Burt CW OBJECTIVES: This investigation describes terrorism preparedness among U.S. office-based physicians and their staffs in identification and diagnosis of terrorism-related conditions, training methods and sources, and assistance with diagnosis and reporting. METHODS: The National Ambulatory Medical Care Survey (NAMCS) is an annual national probability survey of approximately 3,000 U.S. nonfederal, office-based physicians. Terrorism preparedness items were added in 2003 and 2004. RESULTS: About 40 percent of physicians or their staffs received training for anthrax or smallpox, but less than one-third received training for any of the other exposures. About 42.2 percent of physicians, 13.5 percent of nurses, and 9.4 percent of physician assistants and nurse practit... Adv Data journals http://www.medworm.com/rss/comments.php?id=807898 Tue, 24 Jul 2007 04:00:00 +0100 807898 http://www.medworm.com/index.php?rid=807899&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17691217%26dopt%3DAbstract This report presents national estimates of the use of nonfederal short-stay hospitals in the United States during 2005 and selected trend data. Numbers and rates of discharges, diagnoses, and procedures are shown by age and sex. Average lengths of stay are presented for all discharges and for selected diagnostic categories by age and by sex. METHODS: The estimates are based on data collected through the 2005 National Hospital Discharge Survey (NHDS). The survey has been conducted annually by NCHS since 1965. Diagnoses and procedures presented are coded using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM). RESULTS: Trends in the utilization of nonfederal short-stay hospitals show that the overall average length of a hospital stay has declined ... Adv Data journals http://www.medworm.com/rss/comments.php?id=807899 Thu, 12 Jul 2007 04:00:00 +0100 807899 http://www.medworm.com/index.php?rid=776900&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17668724%26dopt%3DAbstract This report presents prevalence estimates for self-reported adult drug use and sexual behaviors in the United States. Data are from the National Health and Nutrition Examination Survey (NHANES) collected from 1999 to 2002. NHANES surveys a stratified multistage probability sample of the civilian noninstitutionalized population of the United States. Tables included in this report present estimates for use of cocaine, including crack or freebase, or other street drugs, and sexual behavior by selected sociodemographic characteristics among adults 20-59 years of age. PMID: 17668724 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=776900 Thu, 28 Jun 2007 04:00:00 +0100 776900 http://www.medworm.com/index.php?rid=550880&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17432488%26dopt%3DAbstract CONCLUSIONS:The associations between SPD and sociodemographic characteristics, health status, and health care utilization are similar to the relationships found between serious mental illnesses (for example, major depression or schizophrenia) and these same variables. Persons with SPD demonstrate disadvantage in both socioeconomic status and health outcomes. PMID: 17432488 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=550880 Fri, 30 Mar 2007 04:00:00 +0100 550880 http://www.medworm.com/index.php?rid=498569&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17370700%26dopt%3DAbstract Authors: Hing E, Burt CW OBJECTIVES: The report uses a multiplicity estimator from a sample of office-based physicians to estimate the number and characteristics of medical practices in the United States. Practice estimates are presented by characteristics of the practice (solo or group, single, or multi-specialty group, size of practice, ownership, location, number of managed care contracts, use of electronic medical records, and use of computerized physician order entry systems). METHODS: Data presented in this report were collected during physician induction interviews for the 2003-04 National Ambulatory Medical Care Survey (NAMCS). The NAMCS is a national probability sample survey of nonfederal physicians who see patients in an office setting in the United States. Radiologists, ane... Adv Data journals http://www.medworm.com/rss/comments.php?id=498569 Mon, 12 Mar 2007 04:00:00 +0100 498569 http://www.medworm.com/index.php?rid=330163&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17180851%26dopt%3DAbstract Authors: Akinbami L, PMID: 17180851 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=330163 Fri, 22 Dec 2006 23:32:02 +0100 330163 http://www.medworm.com/index.php?rid=480343&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17348177%26dopt%3DAbstract CONCLUSIONS: The effect of lowering the total PSA thresholds increases the number of U.S. men who would be referred for screening for prostate cancer. Total and free PSA increased with age in Mexican American, non-Hispanic white, and non-Hispanic black men. Information about the distribution of total, free, and percent free PSA will help guide public health policy in screening for prostate cancer. PMID: 17348177 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=480343 Mon, 04 Dec 2006 05:00:00 +0100 480343 http://www.medworm.com/index.php?rid=271483&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17094643%26dopt%3DAbstract This report presents national estimates of the percentage and number of persons in the U.S. population aged 15-44 who report behaviors that place them at increased risk for acquiring or transmitting human immunodeficiency virus, or HIV. The report also contains data on condom use and HIV testing by persons who report risk behaviors. In addition, estimates of self-reported risk for HIV from the Cycle 6 National Survey of Family Growth (NSFG) are compared with data from other recent national surveys. METHODS: Data from the NSFG Cycle 6, conducted by the Centers for Disease Control and Prevention's (CDC) National Center for Health Statistics (NCHS), are based on interviews with a national sample of the household population of the United States. In-person, face-to-face interviews were conducte... Adv Data journals http://www.medworm.com/rss/comments.php?id=271483 Sun, 12 Nov 2006 03:11:02 +0100 271483 http://www.medworm.com/index.php?rid=236012&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17037024%26dopt%3DAbstract This report presents estimates of structure and process characteristics of hospital EDs related to their capacity to treat medical and surgical emergencies. Estimates of EDs experiencing crowded conditions are also presented. METHODS: Several facility supplements were added to the 2003-04 National Hospital Ambulatory Medical Care Survey (NHAMCS), which were completed by hospital staff. NHAMCS samples nonfederal, short-stay, and general hospitals in the United States. Of all sample hospitals that operated 24-hour EDs, 83 percent completed the supplemental questionnaires. Data from 467 hospitals were weighted to produce national annual estimates of ED characteristics. RESULTS: There was an annual average of 4,500 EDs operating in the United States during 2003 and 2004. Over one-half of EDs s... Adv Data journals http://www.medworm.com/rss/comments.php?id=236012 Sun, 15 Oct 2006 13:35:02 +0100 236012 http://www.medworm.com/index.php?rid=189901&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16964780%26dopt%3DAbstract This report contains prevalence estimates and standard errors for adults, 60 years of age and over, who reported difficulty performing these activities without the aid of special equipment or who were not able to perform these activities. Results are reported by sex, age group, race and ethnicity, and body mass index (BMI). Assessment of functional status plays an important role in monitoring the health problems and needs of older Americans. PMID: 16964780 [PubMed - in process] (Source: Adv Data) Adv Data journals http://www.medworm.com/rss/comments.php?id=189901 Wed, 23 Aug 2006 06:00:00 +0100 189901 http://www.medworm.com/index.php?rid=112676&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16841616%26dopt%3DAbstract This report describes ambulatory care visits made to physician offices in the United States. Statistics are presented on selected characteristics of the physician's practice, the patient, and the visit. Selected trends in office visits are also presented. METHODS: The data presented in this report were collected in the 2004 National Ambulatory Medical Care Survey (NAMCS), a national probability sample survey of visits to office-based physicians in the United States. Sample data are weighted to produce annual national estimates using an estimator that uses a revised nonresponse adjustment. RESULTS: During 2004, an estimated 910.9 million visits were made to physician offices in the United States, an overall rate of 315.9 visits per 100 persons. Overall, 58.9 percent of visits were to physic... Adv Data journals http://www.medworm.com/rss/comments.php?id=112676 Fri, 23 Jun 2006 06:00:00 +0100 112676 http://www.medworm.com/index.php?rid=112675&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16841784%26dopt%3DAbstract This report describes ambulatory care visits to hospital OPDs in the United States. Statistics are presented on selected hospital, patient, and visit characteristics. Selected trends in OPD utilization from 1994 through 2004 are also presented. METHODS: The data presented in this report were collected in the 2004 NHAMCS, a national probability sample survey of visits to emergency and outpatient departments of nonfederal, short-stay, and general hospitals in the United States. Selected comparisons are also made with data from the 2004 National Ambulatory Medical Care Survey (NAMCS), a national probability sample survey of visits to office-based physicians in the United States. Sample data are weighted to produce annual national estimates. RESULTS: During 2004, an estimated 85.0 million visi... Adv Data journals http://www.medworm.com/rss/comments.php?id=112675 Fri, 23 Jun 2006 06:00:00 +0100 112675 http://www.medworm.com/index.php?rid=112674&cid=s_28382_54_f&fid=28382&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16841785%26dopt%3DAbstract This report describes ambulatory care visits to hospital emergency departments (EDs) in the United States in 2004. Statistics are presented on selected hospital, patient, and visit characteristics. Selected trends in ED utilization from 1994 through 2004 are also presented. METHODS: The data presented in this report were collected in the 2004 National Hospital Ambulatory Medical Care Survey (NHAMCS), a national probability sample survey of visits to emergency and outpatient departments of non-Federal, short-stay, and general hospitals in the United States. Sample data are weighted to produce annual national estimates. RESULTS: During 2004, an estimated 110.2 million visits were made to hospital EDs, about 38.2 visits per 100 persons. Visit rates have shown an increasing trend since 1994 fo... Adv Data journals http://www.medworm.com/rss/comments.php?id=112674 Fri, 23 Jun 2006 06:00:00 +0100 112674