MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Adv Dent Res' source. Wed, 28 Oct 2009 13:59:27 +0100 http://www.medworm.com/index.php?rid=2744385&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19710079%26dopt%3DAbstract Authors: Burne RA, Ahn SJ, Wen ZT, Zeng L, Lemos JA, Abranches J, Nascimento M PMID: 19710079 [PubMed - in process] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=2744385 Sat, 29 Aug 2009 16:38:02 +0100 2744385 http://www.medworm.com/index.php?rid=2744384&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19710080%26dopt%3DAbstract Authors: Burwell AK, Litkowski LJ, Greenspan DC PMID: 19710080 [PubMed - in process] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=2744384 Sat, 29 Aug 2009 16:38:02 +0100 2744384 http://www.medworm.com/index.php?rid=2744383&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19710081%26dopt%3DAbstract Authors: Milgrom P, Ly KA, Rothen M PMID: 19710081 [PubMed - in process] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=2744383 Sat, 29 Aug 2009 16:38:02 +0100 2744383 http://www.medworm.com/index.php?rid=2744382&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19710082%26dopt%3DAbstract Authors: He X, Lux R, Kuramitsu HK, Anderson MH, Shi W PMID: 19710082 [PubMed - in process] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=2744382 Sat, 29 Aug 2009 16:38:02 +0100 2744382 http://www.medworm.com/index.php?rid=2744381&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19710083%26dopt%3DAbstract Authors: Leung KP, Abercrombie JJ, Campbell TM, Gilmore KD, Bell CA, Faraj JA, Deluca PP PMID: 19710083 [PubMed - in process] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=2744381 Sat, 29 Aug 2009 16:38:02 +0100 2744381 http://www.medworm.com/index.php?rid=2682847&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19661048%26dopt%3DAbstract Authors: Ten Cate JM PMID: 19661048 [PubMed - as supplied by publisher] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=2682847 Sun, 26 Jul 2009 23:00:00 +0100 2682847 http://www.medworm.com/index.php?rid=1840170&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18810853%26dopt%3DAbstract Authors: Gonzalez-Cabezas C PMID: 18810853 [PubMed - indexed for MEDLINE] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=1840170 Wed, 01 Oct 2008 09:18:52 +0100 1840170 http://www.medworm.com/index.php?rid=1828592&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18810853%26dopt%3DAbstract Authors: Gonzalez-Cabezas C PMID: 18810853 [PubMed - in process] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=1828592 Fri, 26 Sep 2008 09:01:54 +0100 1828592 http://www.medworm.com/index.php?rid=1704123&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694869%26dopt%3DAbstract Authors: Marinho VC PMID: 18694869 [PubMed - in process] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=1704123 Thu, 14 Aug 2008 11:07:58 +0100 1704123 http://www.medworm.com/index.php?rid=1704122&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694870%26dopt%3DAbstract Authors: Kumar JV PMID: 18694870 [PubMed - in process] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=1704122 Thu, 14 Aug 2008 11:07:58 +0100 1704122 http://www.medworm.com/index.php?rid=1704121&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694871%26dopt%3DAbstract Authors: Cury JA, Tenuta LM PMID: 18694871 [PubMed - in process] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=1704121 Thu, 14 Aug 2008 11:07:58 +0100 1704121 http://www.medworm.com/index.php?rid=1704120&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694872%26dopt%3DAbstract Authors: Koo H PMID: 18694872 [PubMed - in process] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=1704120 Thu, 14 Aug 2008 11:07:58 +0100 1704120 http://www.medworm.com/index.php?rid=116983&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DSearch%26db%3DPubMed%26term%3D%2528%2528%2528Adv%2BDent%2BRes%2529%2BAND%2B%25222006%252F07%252F19%2B02%252E41%2522%255BMHDA%255D%253A%25222006%252F07%252F20%2B11%252E00%2522%255BMHDA%255D%2529%2529%2BNOT%2B%2528%2528%2B%2528%2528Adv%2BDent%2BRes%255BTIAB%255D%2529%2529%2BAND%2B%25220001%2522%255BEDAT%255D%253A%25222006%252F07%252F19%2B02%252E41%2522%255BEDAT%255D%2529%2529 28 new PubMed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Adv Dent Res These PubMed results were generated on 2006/07/20PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=116983 Thu, 20 Jul 2006 15:00:46 +0100 116983 http://www.medworm.com/index.php?rid=112903&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672555%26dopt%3DAbstract Authors: Fidel PL Oropharyngeal candidiasis (OPC) caused by the commensal organism, Candida albicans, is the most common oral infection in HIV disease. Although cell-mediated immunity (CMI) by Th1-type CD4+ T-cells is considered the predominant host defense mechanism against OPC, other systemic or local immune mechanisms are critical when blood CD4+ T-cells are reduced below a protective threshold. For example, the Th cytokine profile in saliva may influence resistance or susceptibility to OPC. In OPC lesions, CD8+ T-cells become accumulated at the lamina propria-epithelium interface, suggesting some role for CD8+ T-cells against OPC. However, the absence of CD8+ T-cells close to Candida at the outer epithelium indicates that susceptibility to OPC involves a dysfunction in the CD8+ T-c... Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112903 Wed, 19 Jul 2006 06:40:03 +0100 112903 http://www.medworm.com/index.php?rid=112902&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672556%26dopt%3DAbstract Authors: Teo CG Recognition of the various clinico-epidemiologic forms of Kaposi's sarcoma, a disease putatively caused by an infectious agent, did not provide ready clues as to how that agent might be transmitted, although fecal and sexual routes were implicated. Application of serologic and genome-detection assays, and cell-culture studies following the identification of human herpesvirus 8 as the causative agent now implicate that virus as one that is orally shed. While oral transmission of the virus might account for the viral endemicity in Africa and Mediterranean countries, why it is particularly prevalent among male homosexuals in the West remains more difficult to explain. Such explanation may be sought from behavioral studies into the role saliva plays in sexual interactions. ... Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112902 Wed, 19 Jul 2006 06:40:03 +0100 112902 http://www.medworm.com/index.php?rid=112901&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672557%26dopt%3DAbstract The objective of this investigation was to characterize oral infection and pathogenesis in healthy and immune-suppressed individuals. To characterize oral EBV and KSHV infection, we examined throat washings and oral epithelial cells from HIV-positive and HIV-negative individuals. Quantitative/real-time polymerase-chain-reaction (PCR) assays, transmission electronmicroscopy, immunostaining, and sequence analysis were used to identify viral infection. Virus was isolated from throat-wash samples and was used to infect epithelial and lymphoid cell lines. We detected EBV and KSHV in the oral cavity in healthy and immune-suppressed individuals. Viral strain analysis of KSHV K1 in multiple clones from the oral cavities of healthy persons and immunosuppressed patients detected several strains prev... Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112901 Wed, 19 Jul 2006 06:40:03 +0100 112901 http://www.medworm.com/index.php?rid=112900&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672558%26dopt%3DAbstract The objective of this study was to demonstrate cytomegalovirus (CMV) co-infection in oral KS and to consider its possible significance. We reviewed 20 cases of oral KS in known HIV-positive patients without active CMV disease. HHV8 PCR and CMV immunohistochemistry were performed. HHV8 DNA was present in all cases. CMV inclusions were detected in five cases. The significance of CMV co-infection in oral KS is unclear. The inclusions suggest active infection, although there is no evidence to support CMV in the pathogenesis of KS. Nonetheless, it is vital that physicians be alerted to active CMV infection, so that timely intervention and careful observation can be instituted, ensuring early diagnosis and treatment. PMID: 16672558 [PubMed - indexed for MEDLINE] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112900 Wed, 19 Jul 2006 06:40:03 +0100 112900 http://www.medworm.com/index.php?rid=112899&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672559%26dopt%3DAbstract Authors: Palefsky J HIV-positive men and women are at increased risk of anogenital and oral HPV infection. The risks for HPV-associated high-grade intra-epithelial neoplasia (IN) and cancer are also increased. The prevalence of oral, anal, and cervical HPV infection in HIV-positive individuals compared with HIV-negative individuals increases with progressively lower CD4+ levels, as does incident high-grade IN. In contrast to IN, development of cancer is not related to lower CD4+ level. With increasing grades of IN and cancer, the proportion of tissues with copy-number abnormalities (CNA) increases, with one of the most common genetic changes being amplification of chromosome 3q. The presence of CNA is associated with the integration of HPV DNA into the host genome, with loss of HPV E2 ... Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112899 Wed, 19 Jul 2006 06:40:03 +0100 112899 http://www.medworm.com/index.php?rid=112898&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672560%26dopt%3DAbstract Authors: Hodgson TA, Naidoo S, Chidzonga M, Ramos-Gomez F, Shiboski C The workshop considered five questions reviewing the identification of international oral health care needs of children and adults, and the management of oral diseases in resource-poor countries: (1) What is the role of the dental profession in the management of the HIV-infected individual? (2) Identifying health care needs-What are the epidemiology and disparities of HIV-associated oral lesions in children from different continents? (3) How effective is HIV treatment in controlling oral diseases? (4) Could we develop basic inexpensive oral and dental care protocols for economically deprived HIV-infected patients? and (5) What is the best method of arranging resources to meet the oral health care needs of people with... Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112898 Wed, 19 Jul 2006 06:40:03 +0100 112898 http://www.medworm.com/index.php?rid=112897&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672561%26dopt%3DAbstract Authors: Johnson NW, Glick M, Mbuguye TN The interactions between oral and systemic health are bi-directional and complex, involving many pathways. Regarding health as not merely the absence of disease, but as a state of total well-being, these interactions profoundly influence the progress of many diseases, and the quality of life and economic performance of HIV-infected individuals and populations. The evidence base for specific interactions is currently weak, partly because few good-quality studies have been published, partly because of the naïveté of the instruments currently available for recording these interactions and their inherent complexity. Recording quality of life should be a fundamental aspect of all future studies. The most significant conclusion of this Workshop is t... Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112897 Wed, 19 Jul 2006 06:40:03 +0100 112897 http://www.medworm.com/index.php?rid=112896&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672562%26dopt%3DAbstract Authors: Blignaut E, Patton LL, Nittayananta W, Ramirez-Amador V, Ranganathan K, Chattopadhyay A Workshop participants discussed: the role of HIV subtypes in disease; the treatment of oral candidiasis; the relationship between and among viral load, CD4+ counts, oral candidiasis and oral hairy leukoplakia, pigmentation; and the development of a reliable oral index to predict disease progression. Regarding HIV, the literature revealed that Type I (HIV-I), in particular group M, is involved in the majority (90%) of documented infections, and groups N and O to a lesser extent. Viral envelope diversity led to the subclassification of the virus into nine subtypes, or clades-A-D, F-H, J, and K-each dominating in different geographical areas. HIV-2, currently occurring mostly in West Africa, a... Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112896 Wed, 19 Jul 2006 06:40:03 +0100 112896 http://www.medworm.com/index.php?rid=112895&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672563%26dopt%3DAbstract Authors: Coogan MM, Fidel PL, Komesu MC, Maeda N, Samaranayake LP Oral candidiasis (OC) is the most common mucosal manifestation of HIV infection. This workshop examined OC and other mycoses associated with HIV infection. Historically, blood CD4 cell numbers were the primary prognosticator for the development of OC. However, a study that statistically evaluated the predictive role of HIV viral load vs. CD4 cell counts revealed viral load to be a stronger predictor for OC. The role of biofilms and antifungal resistance in recalcitrant OC is unclear at present. In general, micro-organisms including yeasts in biofilms are more resistant to antifungals than their planktonic counterparts. When the remaining organisms are eliminated, the few resistant organisms may not be problematic, becaus... Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112895 Wed, 19 Jul 2006 06:40:03 +0100 112895 http://www.medworm.com/index.php?rid=112894&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672564%26dopt%3DAbstract Authors: Umadevi M, Adeyemi O, Patel M, Reichart PA, Robinson PG The workshop addressed the following questions with respect to periodontal diseases and bacterial infections seen in HIV infection: (1) What is linear gingival erythema? Is it prevalent only in HIV disease? A crude Delphi technique was used to ascertain whether LGE existed, but a consensus could not be reached. It was agreed that a diagnosis of LGE should be considered only if the lesion persists after removal of plaque in the initial visit. (2) Do periodontal pockets contribute to viremia in HIV infection? At present, the data are not available to answer this question. (3) Do anti-viral drugs reach the sulcular fluid in significant concentrations? No one at the workshop was aware of data that could answer this question. ... Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112894 Wed, 19 Jul 2006 06:40:03 +0100 112894 http://www.medworm.com/index.php?rid=112893&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672565%26dopt%3DAbstract Authors: Flint SR, Tappuni A, Leigh J, Schmidt-Westhausen AM, MacPhail L Highly active anti-retroviral therapy (HAART) has revolutionized the treatment and prognosis of HIV disease and AIDS in those who can take advantage of the treatment. There are currently 20 different anti-retroviral drugs in 4 different classes that are used in specific combinations. Suppression of HIV replication and immune reconstitution are goals of therapy. Since the prevalence of some easily detectable oral manifestations of HIV/AIDS (OMHIV/AIDS) decreases with HAART, it has been suggested that they might be clinically useful surrogate markers of HAART efficacy and immune status. This might be particularly useful if their recurrence presaged or accompanied HAART failure. To date, there has been little work in... Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112893 Wed, 19 Jul 2006 06:40:03 +0100 112893 http://www.medworm.com/index.php?rid=112892&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672566%26dopt%3DAbstract This report reviews: (1) HIV testing and diagnoses with oral fluids; (2) post-natal acquisition of HIV in association with breast-feeding from HIV-positive mothers; and (3) oral sex and HIV transmission. In the first, we examine how oral fluids are used to detect HIV infection and review current consensus on the role of salivary molecules as markers for immunosuppression. Second, lactation-associated HIV acquisition is reviewed, with special consideration of emerging issues associated with the impact of anti-retroviral therapies. Last, we consider current data on the risk of HIV infection in association with oral sex. Investigation of these diverse topics has a common goal: understanding how HIV presents in the oral environment, with an aim to rapid and accessible HIV diagnosis, and improv... Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112892 Wed, 19 Jul 2006 06:40:03 +0100 112892 http://www.medworm.com/index.php?rid=112891&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16672567%26dopt%3DAbstract This report considers evidence that oral epithelium has the potential both to enable and to resist infection by HIV-1. PMID: 16672567 [PubMed - indexed for MEDLINE] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112891 Wed, 19 Jul 2006 06:40:03 +0100 112891 http://www.medworm.com/index.php?rid=112890&cid=s_28264_11_f&fid=28264&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16800065%26dopt%3DAbstract Authors: PMID: 16800065 [PubMed - indexed for MEDLINE] (Source: Adv Dent Res) Adv Dent Res journals http://www.medworm.com/rss/comments.php?id=112890 Wed, 19 Jul 2006 06:40:03 +0100 112890