MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Advances in Anatomic Pathology' source. Thu, 18 Mar 2010 15:10:45 +0100 http://www.medworm.com/index.php?rid=3361233&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2010%2F03000%2FEndometrial_Stromal_Sarcomas__A_Review_of.3.aspx Endometrial stromal tumors are uncommon mesenchymal tumors of the uterus. The classification of these tumors has evolved and the most current World Health Organization classification (2003) divides these neoplasms into: endometrial stromal nodule, low-grade endometrial stromal sarcoma, and undifferentiated endometrial sarcoma. The salient clinicopathologic features of these tumors are described, and a comprehensive review of literature pertaining to potential prognostic factors in endometrial stromal sarcomas is provided. Clinical factors, including age, race, parity and menopausal status, and pathologic factors, including tumor size, tumor stage, nuclear atypia, mitotic activity, tumor necrosis, lymphovascular space invasion, DNA ploidy and proliferative activity, and expression of hormon... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3361233 Mon, 01 Mar 2010 00:00:00 +0100 3361233 http://www.medworm.com/index.php?rid=3340949&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2010%2F03000%2FState_of_the_Art%2C_Nomenclature%2C_and_Points_of.1.aspx The following communication summarizes the proceedings of a one-day International Workshop focusing on the histology of benign melanocytic nevi. Areas of controversy identified in 6 focus sessions were the nomenclature and relationships among common nevi including nevi with halo reactions, traumatized nevi, "dysplastic" nevi, and nevi from particular anatomic sites; developmental biology and frequency of malignant transformation associated with congenital nevi; the characterization and biologic nature of atypical spitzoid neoplasms; the basic definition of particular melanocytic cellular phenotypes, and the nomenclature and biologic nature of many candidate blue nevi, combined nevi, and other controversial lesions such as deep penetrating nevus and pigmented epithelioid melanocytoma. Conce... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3340949 Mon, 01 Mar 2010 00:00:00 +0100 3340949 http://www.medworm.com/index.php?rid=3245784&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1994%2F09000%2FCystic_Nephroma_and_Cystic_Partially.7.pdf On: Multilocular Cystic Nephroma. Kajani N, Rosenberg BF, Bernstein J, J Urol Pathol 1993;1:33-42 (C) Williams & Wilkins 1994. All Rights Reserved. (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3245784 Sat, 06 Feb 2010 15:11:07 +0100 3245784 http://www.medworm.com/index.php?rid=3214629&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F2000%2F07030%2FHepatitis_C_itself_does_not_contribute.11.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3214629 Thu, 28 Jan 2010 15:22:38 +0100 3214629 http://www.medworm.com/index.php?rid=3210395&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F2000%2F07020%2FAn_update_on_SETTLE.10.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3210395 Wed, 27 Jan 2010 14:57:18 +0100 3210395 http://www.medworm.com/index.php?rid=3144353&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1995%2F01000%2FAntigen_Unmasking_in_Formalin_Fixed_Routinely.44.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3144353 Wed, 06 Jan 2010 14:57:26 +0100 3144353 http://www.medworm.com/index.php?rid=3210397&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2010%2F01000%2FThe_Physicians_Quality_Reporting_Initiative_.7.aspx The Physicians Quality Reporting Initiative (PQRI) was instituted in the latter half of 2007. PQRI is a voluntary reporting system in which the aim is to improve patient care, whereas at the same time, an eligible practitioner may receive an incentive payment for successful participation. Two pathology-specific measures were instituted in 2008; 1 for breast cancer reporting and the other for colon cancer reporting. In 2009, Current Procedural Terminology Category II code 3250F was instituted, which allows proper coding of cases from metastatic sites when ICD 9 code and Current Procedural Terminology Category I inclusion criteria are met. After the review of the 2007 data obtained from other specialties, submission of invalid codes was predominantly attributed to failure to adhere to measur... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3210397 Fri, 01 Jan 2010 00:00:00 +0100 3210397 http://www.medworm.com/index.php?rid=3187482&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2010%2F01000%2FHistiocytic_Disorders_of_the_Lung.2.aspx Histiocytic proliferations involving the lung span a broad spectrum. Some proliferations are primary; others represent a histiocytic response secondary to conditions in which there may be isolated lung involvement or the lung may be involved as part of a systemic process. Primary histiocytic lung disorders, particularly those of uncertain histogenesis are a heterogeneous and intriguing group of disorders. Although they have been the focus of attention by clinicians and pathologists alike, much is unknown about their etiopathogenesis. Owing to this uncertainty, our understanding of these processes is in a state of flux, and is likely to change as more information is brought to light. This review will focus on pulmonary histiocytic proliferations of uncertain histogenesis. Other histiocytic ... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3187482 Fri, 01 Jan 2010 00:00:00 +0100 3187482 http://www.medworm.com/index.php?rid=3181141&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2010%2F01000%2FSmall_Cell_Tumors_of_Bone.1.aspx Bone tumors are fortunately rare, but small cell tumors of bone are a relatively common subset of these lesions. They comprise of a diverse group of primary and metastatic neoplasms in both children and adults. The most common small cell tumors of bone include Ewing sarcoma/primitive neuroectodermal tumor, small cell osteosarcoma, multiple myeloma, lymphoma, leukemia, neuroblastoma, rhabdomyosarcoma, and Langerhans cell histiocytosis. Although each entity has its distinctive features, the differential diagnosis of this group of tumors is still challenging because they are all "small, blue, and round cell tumors", histologically. The correct diagnosis of small cell tumors of bone depends on an evaluation of clinical, radiologic, pathologic, and genetic features. Patients' age and sex are ve... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3181141 Fri, 01 Jan 2010 00:00:00 +0100 3181141 http://www.medworm.com/index.php?rid=3157132&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2010%2F01000%2FKRAS_Mutation_Testing_in_Human_Cancers__The.3.aspx A number of studies have shown that although antiepidermal growth factor receptor (EGFR) monoclonal antibodies are effective treatments for metastatic colorectal cancer (mCRC), only patients with wild-type KRAS tumors derive clinical benefit from these therapies. The anti-EGFR monoclonal antibodies panitumumab and cetuximab are approved in the United States for treatment of mCRC refractory to chemotherapy but are not recommended for use in patients with mutations in KRAS codons 12 or 13. Similarly, panitumumab is approved for the treatment of mCRC only in patients with wild-type KRAS in Europe and Canada. It is clear that KRAS mutational analysis will become an important aspect of disease management in patients with mCRC. Consequently, it will be important for pathologists and oncologists ... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3157132 Fri, 01 Jan 2010 00:00:00 +0100 3157132 http://www.medworm.com/index.php?rid=3155046&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2010%2F01000%2FAn_Update_on_Lung_Cancer_Staging.4.aspx This article reviews the changes in criteria for the tumor, node, metastasis components and discusses the issues that will be faced by pathologists when examining lung cancer specimens, including recommendations for tumor measurement, differentiation of multiple primary tumors versus metastases, and visceral pleural invasion. (C) 2010 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3155046 Fri, 01 Jan 2010 00:00:00 +0100 3155046 http://www.medworm.com/index.php?rid=3098663&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1994%2F09000%2FMismatch_Repair_Gene__The_Underlying_Defect_of.36.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3098663 Fri, 18 Dec 2009 14:54:53 +0100 3098663 http://www.medworm.com/index.php?rid=3098662&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1994%2F11000%2FIn_situ_carcinoma_involving_the_anterior.23.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3098662 Fri, 18 Dec 2009 14:54:53 +0100 3098662 http://www.medworm.com/index.php?rid=3094597&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1995%2F07000%2FSelective_overexpression_of_CCND1__bcl_1_cyclin.28.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3094597 Thu, 17 Dec 2009 14:56:39 +0100 3094597 http://www.medworm.com/index.php?rid=3091202&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1998%2F07000%2FImprovement_needed_in_distinguishing_non_invasive.27.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3091202 Wed, 16 Dec 2009 14:51:34 +0100 3091202 http://www.medworm.com/index.php?rid=3091201&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F2000%2F07030%2FSecondary_chromosomal_changes_in_Ewing_s_sarcoma.16.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3091201 Wed, 16 Dec 2009 14:51:34 +0100 3091201 http://www.medworm.com/index.php?rid=3087486&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1999%2F09000%2FReproducibility_of_new_classification_schemes_for.11.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3087486 Tue, 15 Dec 2009 15:00:31 +0100 3087486 http://www.medworm.com/index.php?rid=3073659&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1994%2F09000%2FSclerosing_peritonitis_and_ovarian_luteinized.23.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073659 Thu, 10 Dec 2009 14:50:15 +0100 3073659 http://www.medworm.com/index.php?rid=3073655&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1994%2F09000%2FEpstein_Barr_virus__EBV___cause_of.19.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073655 Thu, 10 Dec 2009 14:50:15 +0100 3073655 http://www.medworm.com/index.php?rid=3073654&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1995%2F07000%2FParents_siblings_with_head_and_neck_squamous_cell.20.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073654 Thu, 10 Dec 2009 14:50:15 +0100 3073654 http://www.medworm.com/index.php?rid=3073653&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1994%2F09000%2FLymphangiomyomatosis_and_Angiomyolipoma_.6.pdf On: Lymphangiomyomatosis and Angiomyolipoma: Closely Related Entities Characterized by Hamartomatous Proliferation of HMB-45-Positive Smooth Muscle. Chan JKC, Tsang WYW, Pau MY, Tang MC, Pang SW, Fletcher CDM, Histopathology 1993;22:445-55 (C) Williams & Wilkins 1994. All Rights Reserved. (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073653 Thu, 10 Dec 2009 14:50:15 +0100 3073653 http://www.medworm.com/index.php?rid=3073650&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1999%2F07000%2FInfants_and_ectopic_thymus_in_the_neck.10.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073650 Thu, 10 Dec 2009 14:50:15 +0100 3073650 http://www.medworm.com/index.php?rid=3073649&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1995%2F01000%2FKitchen_Ideas_in_the_Immunohistochemistry.1.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073649 Thu, 10 Dec 2009 14:50:15 +0100 3073649 http://www.medworm.com/index.php?rid=3073646&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1995%2F07000%2FPerinatal_transmisson_of_high_risk_human.9.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073646 Thu, 10 Dec 2009 14:50:15 +0100 3073646 http://www.medworm.com/index.php?rid=3073644&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1994%2F09000%2FImmunohistochemical_studies_for_distinction.25.pdf No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073644 Thu, 10 Dec 2009 14:50:15 +0100 3073644 http://www.medworm.com/index.php?rid=3073643&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F2000%2F07030%2FParachordoma_Exists___But_What_Is_It_.2.pdf Summary: Parachordoma is a very rare peripheral soft tissue tumor of unknown lineage, which has been described under other names, all of which imply a similarity to chordoma. It forms a circumscribed firm tumor, usually in deep soft tissue, with a variety of histologic patterns and cytologic features, including cords and nests of cells, some of which are vacuolated. The ultrastructure and immunophenotype indicate epithelial differentiation and parachordomas are additionally S-100 protein positive. This tumor is distinct from extraskeletal myxoid chondrosarcoma and probably from soft tissue myoepithelioma. While histologically it somewhat resembles chordoma, parachordoma has a wider range of appearances, and the two neoplasms differ in their detailed cytokeratin immunophenotype and their cl... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073643 Thu, 10 Dec 2009 14:50:15 +0100 3073643 http://www.medworm.com/index.php?rid=3073642&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F2000%2F07030%2FA_Conceptual_Shift_in_the_Grading_of_Meningiomas.4.pdf Summary: Grading schemes for meningiomas have traditionally designated tumors as "meningioma," "atypical meningioma," or "anaplastic (malignant) meningioma," depending upon the presence of histopathologic features thought to indicate aggressive behavior. In the past, most systems have considered brain invasion by tumor as the best evidence of malignancy. Perry et al. have recently investigated the significance brain invasion as a prognostic feature in meningiomas. The authors studied a series of 116 patients who had been diagnosed previously with "malignant meningioma" due to the presence of brain invasion, histologic anaplasia, or metastasis. On the basis of a multivariate analysis of histopathologic features and their relationship to tumor recurrence and patient survival, the authors con... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073642 Thu, 10 Dec 2009 14:50:15 +0100 3073642 http://www.medworm.com/index.php?rid=3073639&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F1994%2F09000%2FPolymerase_Chain_Reaction_and_Single_Strand.1.pdf Of the various polymerase chain reaction-based techniques available to detect DNA mutations, single-strand conformation polymorphism analysis is being used increasingly owing to its simplicity, sensitivity, and applicability to large numbers of specimens. Furthermore, prior knowledge of the site or type of mutation is not needed, the only requirement being the availability of appropriate primers. The authors review the theoretical and practical aspects of this technique, and detail some of its major applications in the detection of gene mutations in both neoplastic and nonneoplastic disorders. (C) Williams & Wilkins 1994. All Rights Reserved. (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073639 Thu, 10 Dec 2009 14:50:15 +0100 3073639 http://www.medworm.com/index.php?rid=3073636&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fpdfs.journals.lww.com%2Fanatomicpathology%2F2000%2F07020%2FAtypical_Subcutaneous_Fatty_Tumors.4.pdf Summary: Atypical fatty tumors present problems of terminology and diagnosis. While atypical fatty tumors that are located in subcutaneous tissues have an extremely good prognosis, local recurrence and transformation to a higher grade tumor may occur. Allen et al document the morphologic features and behavior of 37 atypical subcutaneous fatty tumors and describe a system of grading. The commentary discusses the terminology of atypical fatty tumors, the relevance of the proposed grading system, and the significance of a spindle cell component in atypical subcutaneous fatty tumors. (C) 2000 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073636 Thu, 10 Dec 2009 14:50:15 +0100 3073636 http://www.medworm.com/index.php?rid=3010717&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F11000%2FCystic_Lymphangioma_like_Adenomatoid_Tumor_of_the.6.aspx Adenomatoid tumors (AT) are usually found in the genital tract of both sexes. They are very rarely located in extragenital sites, and are exceedingly rare in the adrenal. AT of the adrenal gland (AT-AG) are nonfunctioning, usually discovered incidentally and confused on imaging with other more common adrenal neoplasms. The overwhelming majority occur in males. Thirty-four cases have been reported so far, more often presenting grossly as solid tumors, rarely as solid with cystic areas, and 5 cases were almost entirely cystic. At histology they can be either circumscribed or locally infiltrative, and may pose diagnostic difficulties when the pathologist relies on morphology alone or is challenged on frozen section. On light microscopy the diagnosis may be very difficult if the tumor is rich ... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3010717 Sun, 01 Nov 2009 00:00:00 +0100 3010717 http://www.medworm.com/index.php?rid=2941617&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F11000%2FColorectal_Cancer_Due_to_Deficiency_in_DNA.4.aspx Lynch syndrome (LS) is an autosomal dominant cancer predisposition syndrome attributable to deleterious germline mutations in mismatch repair (MMR) genes. The syndrome is typified by early-onset, frequently right-sided colorectal cancers (CRCs) with characteristic histologic features and tendency for multiplicity and an increased risk for extracolonic tumors at particular sites; it accounts for 1% to 5% of CRC. Deficient mismatch repair (dMMR) function manifests as immunohistochemically detectable absence of one or more MMR proteins and microsatellite instability (MSI). Approximately 15% of sporadic, noninherited CRC are characterized by high-level MSI, nearly always owing to transcriptional silencing of MLH1; these sporadic and LS cases exhibit considerable phenotypic overlap. Identificat... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2941617 Fri, 30 Oct 2009 14:55:15 +0100 2941617 http://www.medworm.com/index.php?rid=2937014&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F11000%2FPlasmacytoid_Dendritic_Cells__Physiologic_Roles.3.aspx Plasmacytoid dendritic cells (PDCs) have perplexed pathologists for decades, undergoing multiple adjustments in nomenclature as their lineage and functions have been characterized. Although PDCs account for less than 0.1% of peripheral blood mononuclear cells, they serve as a principal source of interferon-[alpha] and are also known as interferon-I producing cells (IPCs). Upon activation in vitro, they can differentiate into dendritic cells, and recent studies have substantiated a potential role in antigen presentation. Thus, PDCs may act as a link between innate and adaptive immunity. Normally found in small quantities in primary and secondary lymphoid organs, PDCs accumulate in a variety of inflammatory conditions, including Kikuchi-Fujimoto lymphadenopathy, hyaline-vascular Castleman di... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2937014 Thu, 29 Oct 2009 14:57:11 +0100 2937014 http://www.medworm.com/index.php?rid=2937013&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F11000%2FFluorescence_In_Situ_Hybridization_in_the.2.aspx This paper presents an overview of the role of fluorescence in situ hybridization (FISH) in the diagnosis of soft tissue neoplasms. Many soft tissue neoplasms harbor characteristic translocations or amplification of gene regions, which can be assessed by FISH, and can be used to assist in their diagnosis. We discuss the major morphologic categories in which FISH has come to be used including high-grade round cell sarcomas, spindle cell sarcomas, low-grade myxoid neoplasms, adipocytic neoplasms, and malignant melanocytic neoplasms on the basis of a recent review of soft tissue neoplasms which were analyzed by FISH. We also review the molecular alterations (translocations and amplification of gene regions), which have come to define many of these diagnostic entities and the most effective wa... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2937013 Thu, 29 Oct 2009 14:57:11 +0100 2937013 http://www.medworm.com/index.php?rid=2932991&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F11000%2FCore_Components_of_a_Comprehensive_Quality.5.aspx In this article the core components of a comprehensive quality assurance and improvement plan are outlined. Quality anatomic pathology work comes with focus on accurate, timely, and complete reports. A commitment to continuous quality improvement and a systems approach with a persistent effort helps to achieve this end. Departments should have a quality assurance and improvement plan that includes a risk assessment of real and potential problems facing the laboratory. The plan should also list the individuals responsible for carrying out the program with adequate resources, a defined timetable, and annual assessment for progress and future directions. Quality assurance monitors should address regulatory requirements and be organized by laboratory division (surgical pathology, cytology, etc... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2932991 Wed, 28 Oct 2009 15:04:02 +0100 2932991 http://www.medworm.com/index.php?rid=2837645&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F09000%2FSelective_Pathologies_of_the_Head_and_Neck_in.7.aspx The range of pathology seen in the head and neck region is truly amazing and to a large extent probably mirrors the complex signaling pathways and careful orchestration of events that occurs between the primordial germ layers during the development of this region. As is true in general for the entire discipline of pediatric pathology, the head and neck pathology within this age group is as diverse and different as its adult counterpart. Cases that come across the pediatric head and neck surgical pathology bench are more heavily weighted toward developmental and congenital lesions such as branchial cleft anomalies, thyroglossal duct cysts, ectopias, heterotopias, choristomas, and primitive tumors. Many congenital "benign" lesions can cause significant morbidity and even mortality if they co... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2837645 Mon, 31 Aug 2009 23:00:00 +0100 2837645 http://www.medworm.com/index.php?rid=2826696&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F09000%2FBenign_Cartilaginous_Tumors_of_Bone__From.4.aspx Benign cartilaginous tumors of bones, intrinsic to their name, are tumors forming cartilaginous matrix with a clinically benign behavior. In this group, we recognize osteochondromas, (en)chondromas, chondroblastomas, and chondromyxoid fibromas. This group includes common tumors, that is, osteochondroma and (en)chondroma as well as rare tumors such as chondroblastoma and chondromyxoid fibroma. Several benign and malignant tumors may mimic benign cartilaginous tumors of bones. We reviewed the main morphologic features and the differential diagnosis is discussed. The genetics of these tumors is intriguing ranging from single gene event (ie, EXT mutation in multiple osteochondromas) to heterogeneous rearrangements with no recurrent involved chromosomal regions such as in chondroblastoma. The m... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2826696 Mon, 31 Aug 2009 23:00:00 +0100 2826696 http://www.medworm.com/index.php?rid=2787705&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F09000%2FOlfactory_Neuroblastoma__A_Review_and_Update.6.aspx Olfactory neuroblastoma (ONB) is a malignant neuroectodermal tumor that typically occurs in the superior nasal cavity. It is a distinct entity with features that include nesting, low-grade stippled nuclei, and neurofibrillary stroma with formation of pseudorosettes. It has a distinctive immunoprofile that includes keratin negativity, neuroendocrine marker positivity, and S100 positive sustentacular cells, which surround the nests of tumor in a supportive manner. Although the typical clinicopathologic features leave little room for misinterpretation, the wide variability in this tumor may cause diagnostic difficulty. This includes immunophenotypic diversity or patchy staining with immunomarkers, wide spectrum of grade and histology, posttreatment changes, and occasional divergent differenti... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2787705 Mon, 31 Aug 2009 23:00:00 +0100 2787705 http://www.medworm.com/index.php?rid=2784308&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F09000%2FBoard_Review_Series__Pathology%2C_4th_Ed.8.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2784308 Mon, 31 Aug 2009 23:00:00 +0100 2784308 http://www.medworm.com/index.php?rid=2760342&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F09000%2FPoorly_Differentiated_Thyroid_Carcinoma__A.2.aspx The term poorly differentiated thyroid carcinoma (PDTC) was first proposed in the 1980s, but it was not definitively recognized as a distinct pathologic entity until the most recent classification of endocrine tumors by the World Health Organization in 2004. More recently, as a result of discussions in Turin, Italy, in 2006, diagnostic criteria were made more specific by a consensus of expert thyroid pathologists. The histologic and cytologic aspects are detailed with particular attention to key features helpful in the diagnosis of PDTC, both in surgical pathology and in cytology-based studies. Histologically, insular, solid, and/or trabecular architecture, along with at least one of the following: convoluted nuclei, mitotic activity (>3/10 HPF), or tumor necrosis, are required for a diagn... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2760342 Mon, 31 Aug 2009 23:00:00 +0100 2760342 http://www.medworm.com/index.php?rid=2742946&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F09000%2FThe_Expression_and_Diagnostic_Utility_of_p63_in.5.aspx p63 plays a key role in epithelial development in various organs, being expressed in myoepithelial cells and in basal cells of stratified epithelia. In the female genital tract, p63 is expressed in the basal and parabasal cells of mature cervical, vaginal and vulval squamous epithelium, and also in cervical reserve cells at the transformation zone and in immature metaplastic and atrophic cervical squamous epithelium. In this review, the diagnostic utility of p63 immunohistochemical staining in various pathologic scenarios within the female genital tract is discussed. Cervical microglandular hyperplasia is p63 positive with a characteristic subcolumnar location due to expression in reserve cells. There is increased expression in cervical intraepithelial neoplasia, in accordance with the deg... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2742946 Sat, 29 Aug 2009 12:32:09 +0100 2742946 http://www.medworm.com/index.php?rid=2732495&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F09000%2FOvarian_Low_grade_and_High_grade_Serous_Carcinoma_.1.aspx Ovarian serous carcinomas have been graded using various systems. Recently, a 2-tier system in which tumors are subdivided into low grade and high grade has been proposed. This approach is simplistic, reproducible, and based on biologic evidence indicating that both tumors develop via different pathways. Low-grade serous carcinomas exhibit low-grade nuclei with infrequent mitotic figures. They evolve from adenofibromas or borderline tumors, have frequent mutations of the KRAS, BRAF, or ERBB2 genes, and lack TP53 mutations (Type I pathway). The progression to invasive carcinoma is a slow step-wise process. Low-grade tumors are indolent and have better outcome than high-grade tumors. In contrast, high-grade serous carcinomas have high-grade nuclei and numerous mitotic figures. Identification... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2732495 Wed, 26 Aug 2009 12:37:27 +0100 2732495 http://www.medworm.com/index.php?rid=2732494&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F09000%2FLymphocytic_Disorders_of_the_Gastrointestinal.3.aspx Increased numbers of intraepithelial lymphocytes (lymphocytosis) can be found in the esophagus, stomach, small intestine, and colon in a variety of clinical circumstances. This review, directed at practicing pathologists, portrays the normal resident lymphocyte population in the mucosa of each segment of the digestive tract and discusses the different situations that may result in quantitative or qualitative alterations of intraepithelial lymphocytes. Esophageal lymphocytosis has not been fully characterized and its clinical significance, if any, awaits definition. Thus, this diagnosis is presently discouraged. In the stomach, it is particularly important to exclude Helicobacter pylori infection and celiac sprue before diagnosing lymphocytic gastritis. Duodenal lymphocytic infiltrates, ine... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2732494 Wed, 26 Aug 2009 12:37:26 +0100 2732494 http://www.medworm.com/index.php?rid=2608463&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F07000%2FA_New_Collaborative_Online_Medical_Encyclopedia.8.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2608463 Tue, 30 Jun 2009 23:00:00 +0100 2608463 http://www.medworm.com/index.php?rid=2593962&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F07000%2FFatal_Systemic_Venous_Air_Embolism_During.7.aspx We report on an additional such fatal case, concerning a 78-year-old male patient, who several years previously had undergone surgical gastroduodenal resection with cholecystectomy and papillotomy, and was admitted for recurrent ascending cholangitis secondary to bile duct stones. During the third endoscopic cholangioscopic procedure for removal of bile duct stones, sudden cardiopulmonary arrest occurred. Death was due to massive pulmonary air embolism. Cerebral air embolism was also found. Autopsy was performed. A spontaneous duodenobiliary fistula was found. On the basis of bench radiologic investigation (retrograde suprahepatic venography and anterograde portography), it was demonstrated that the air insufflated during duodenal endoscopy, which entered through the spontaneous duodeno-bi... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2593962 Tue, 30 Jun 2009 23:00:00 +0100 2593962 http://www.medworm.com/index.php?rid=2586498&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F07000%2FDiagnostic_Problems_in_Breast_Pathology.9.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2586498 Tue, 30 Jun 2009 23:00:00 +0100 2586498 http://www.medworm.com/index.php?rid=2572408&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F07000%2FGoblet_or_Signet_Ring_Cells__That_is_the_Question.6.aspx Goblet cell carcinoid tumor is a rare mixed endocrine-exocrine neoplasm of the appendix. It carries an intermediate biologic behavior between a classic carcinoid tumor and a conventional adenocarcinoma. There has been a general lack of clinicopathologic parameters that can be reliably used to predict the clinical course and patient outcome. A recent retrospective study of a large number of appendiceal goblet cell carcinoids has shown that these tumors can be stratified into 3 subgroups based on careful histologic analysis: typical goblet cell carcinoid (group A); adenocarcinoma ex goblet cell carcinoid, signet ring cell type (group B); and adenocarcinoma ex goblet cell carcinoid, poorly differentiated carcinoma type (group C). Clinical follow-up data show that the histologic classification... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2572408 Tue, 30 Jun 2009 23:00:00 +0100 2572408 http://www.medworm.com/index.php?rid=2558545&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F07000%2FCastleman_Disease__An_Update_on_Classification_and.5.aspx Since its initial description, researchers have expanded the spectrum of Castleman disease to include not only the classic and well-recognized hyaline-vascular type, but also the plasma cell type and multicentric types of broader histologic range, including human herpes virus-8-associated Castleman disease. These less common subtypes of Castleman disease are less familiar, and may be under-recognized. Also of practical importance, current authors are restructuring the classification of multicentric Castleman disease to accommodate the emerging pathogenic role of human herpes virus-8 and its association with the recently described plasmablastic variant. In addition to an increased risk of lymphoma, patients with Castleman disease also are at increased risk for other related neoplasms, inclu... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2558545 Tue, 30 Jun 2009 23:00:00 +0100 2558545 http://www.medworm.com/index.php?rid=2558544&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F07000%2FMultigene_Classifiers%2C_Prognostic_Factors%2C_and.3.aspx A series of multigene classifiers, prognostic and predictive tests have recently been introduced as potentially useful adjuncts for the management of recently diagnosed breast cancer patients. These tests have used both slide-based methods including immunohistochemistry and fluorescence in situ hybridization and nonmorphology driven molecular platforms including quantitative multiplex real time polymerase chain reaction and genomic microarray profiling. In this review, a series of partially and completely commercialized multigene assays are compared with the standard breast cancer clinico-pathologic variables and biomarkers and evaluated as to the level of their scientific validation, current clinical utility, regulatory approval status, and estimated cost-benefit. A comparison of the Onco... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2558544 Tue, 30 Jun 2009 23:00:00 +0100 2558544 http://www.medworm.com/index.php?rid=2554690&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F07000%2FDiffuse_Aggressive_B_cell_Lymphomas.4.aspx Diffuse aggressive B-cell lymphomas comprise a relatively common and increasingly diverse group of neoplasms. Newer modalities including gene expression profiling and an increasing panel of immunohistochemical markers have contributed to greater accuracy in defining these entities. Attention is paid not only to the neoplastic cells but also to the cellular and stromal milieu in which they proliferate. These distinctions may have therapeutic implications as well, with improved outcome related to newer and sometimes targeted therapies. At the same time there is increasing understanding of the overlap, which occurs in the grey zone between diffuse large B-cell lymphoma and Burkitt lymphoma as well as between diffuse large B-cell lymphoma and Hodgkin lymphoma. This review aims to provide pract... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2554690 Tue, 30 Jun 2009 15:50:19 +0100 2554690 http://www.medworm.com/index.php?rid=2516392&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F07000%2FUpdate_on_Percutaneous_Needle_Biopsy_of.1.aspx Certain nonmalignant lesions encountered on percutaneous breast biopsies pose dilemmas with regard to the most appropriate clinical management subsequent to needle biopsy (ie, surgical excision vs. follow-up). These lesions include columnar cell lesions, atypical ductal hyperplasia, lobular neoplasia, papillary lesions, radial scars, fibroepithelial lesions, and mucocele-like lesions. As minimally invasive diagnostic procedures are now standard it is more important than ever to be aware of the limitations of percutaneous biopsy, particularly with regard to apparently benign lesions because of the risk that the radiologically detected lesion may harbor malignant disease not represented in the biopsy specimen. This underscores the importance of radiologic-pathologic correlation. Increasingly... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2516392 Fri, 26 Jun 2009 10:22:29 +0100 2516392 http://www.medworm.com/index.php?rid=2493840&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F07000%2FKRAS_Mutation_Testing_in_Colorectal_Cancer.2.aspx In the US, colorectal cancer is the third leading cause of cancer-related death. Approximately 20% of patients present with metastatic disease, and an additional 30% to 40% develop metastasis during the course of their disease. Patients with metastatic colon cancer have a 5-year survival rate of only 11%. Although surgery is the mainstay of treatment for early stage colon cancer, adjuvant treatment is usually used in patients advanced stage disease. In particular, epidermal growth factor receptor (EGFR) inhibitor therapies have emerged as effective treatments in a subset of patients with metastatic colorectal carcinoma. Two anti-EGFR biologics, cetuximab and panitumumab, have been approved by the Food and Drug Administrations for the treatment of refractory metastatic colorectal carcinoma.... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493840 Thu, 25 Jun 2009 08:07:24 +0100 2493840 http://www.medworm.com/index.php?rid=2481641&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F05000%2FIoachim_s_Lymph_Node_Pathology%2C_4th_Ed.7.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481641 Fri, 01 May 2009 04:00:00 +0100 2481641 http://www.medworm.com/index.php?rid=2481639&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F05000%2FThe_Washington_Manual_of_Surgical_Pathology.8.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481639 Fri, 01 May 2009 04:00:00 +0100 2481639 http://www.medworm.com/index.php?rid=2481638&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F05000%2FMultiple_Spontaneous_Liver_Cell_Adenomas_of.6.aspx In 1999, Nguyen et al divided focal nodular hyperplasia (FNH) in 2 groups, the classical and nonclassical. The former also included those cases of FNH with classical characteristics exhibited "on a subtle scale," whereas the latter included among others mainly the telangiectatic FNH (T-FNH) variant. Hepatocellular adenoma (HCA) was classically considered by definition a neoplasm with no ductal or ductular differentiation, but today the spectrum of HCA does include variant 3, which may have CK7+ ductules. Owing to genotypic-phenotypic correlation, T-FNH (synonymous with progressive FNH of others) is not considered yet as part of the spectrum of FNH, instead it is diagnosed as a variant of HCA, which now includes 4 variants. Variant-3, which may contain CK7+ ductules, and is also termed HCA ... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481638 Fri, 01 May 2009 04:00:00 +0100 2481638 http://www.medworm.com/index.php?rid=2481637&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F05000%2FMinimally_Invasive_Adenocarcinomas_of_the_Lung.5.aspx Current World Health Organization (WHO) classification of lung adenocarcinomas includes noninvasive bronchioloalveolar carcinoma (BAC) and several patterns of invasive adenocarcinoma. The most common is a mixed subtype of adenocarcinoma. This group is very heterogenous and includes a wide spectrum of tumors ranging from adenocarcinomas with a dominant BAC growth pattern (lepidic growth) to frankly invasive adenocarcinoma with no BAC component. There is a tendency among clinicians to regard tumor as BAC if any significant amount of lepidic growth pattern within the tumor is identified. The change in WHO definition of BAC and introduction of mixed subtype of adenocarcinoma resulted in disconnect between surgical pathologists and clinicians regarding the use of terminology and criteria for di... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481637 Fri, 01 May 2009 04:00:00 +0100 2481637 http://www.medworm.com/index.php?rid=2481636&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F05000%2FSelected_Topics_in_the_Evaluation_of_Pediatric.3.aspx The practice of pediatric gastrointestinal pathology provides specific challenges to the pathologist. Often the clinical information accompanying a biopsy specimen will read simply, "failure to thrive." Other situations, such as the evaluation of a neonate's rectal suction biopsy for Hirschsprung disease, are notorious for providing diagnostic challenges in high-pressure situations. In this review, we will discuss several commonly encountered situations in pediatric pathology: the evaluation of pediatric esophageal eosinophilia, a child who has swallowed a non food item, caustic substance, or hot liquid, the evaluation of a pediatric colorectal biopsy with focal active colitis, and the evaluation of rectal suction biopsies for Hirschsprung disease. With each topic, we will discuss a genera... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481636 Fri, 01 May 2009 04:00:00 +0100 2481636 http://www.medworm.com/index.php?rid=2481634&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F05000%2FThe_Discovery_of_Common_Recurrent_Transmembrane.2.aspx Recurrent gene fusions and chromosomal rearrangements were previously thought to be the primary oncogenic mechanism of hematological malignancies and sarcomas. The recent discovery of recurrent gene fusions in a majority of prostate cancers represents a paradigm shift in understanding the molecular mechanisms of one of the most prevalent epithelial malignancies, with important clinical and biologic implications. The prostate cancer gene fusions that have been identified so far are characterized by 5'-genomic regulatory elements, most notably the androgen-controlled prostate specific gene, transmembrane protease serine 2, fused to members of the erythroblastosis virus E26 transforming sequence family of transcription factors, most notably ERG, leading to the overexpression of oncogenic tran... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481634 Fri, 01 May 2009 04:00:00 +0100 2481634 http://www.medworm.com/index.php?rid=2481633&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F05000%2FDiagnosing_Gastroesophageal_Reflux_Disease__The.4.aspx Gastroesophageal reflux disease (GERD) is a common disease frequently encountered by surgical pathologists. Although the pathogenesis and clinical features of the disease have been studied for years, many unanswered questions remain. Typical clinical symptoms along with the endoscopic findings, pH monitoring, and biopsies, all support the diagnosis. However, these tests may yield conflicting findings, and at present there is no gold standard for the diagnosis of GERD. In patients with normal or nearly normal endoscopic findings (nonerosive reflux disease), the major diagnostic burden lies with the histology. The histologic diagnosis of GERD is based on a combination of findings, including basal cell hyperplasia, papilla elongation, inflammation, and dilatation of intercellular spaces. Howe... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481633 Fri, 01 May 2009 04:00:00 +0100 2481633 http://www.medworm.com/index.php?rid=2481632&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F05000%2FMerkel_Cell_Carcinoma__Review.1.aspx Merkel cell carcinoma (MCC) is synonymous with primary cutaneous neuroendocrine carcinoma. It tends to affects elderly whites, but there is also an increased incidence among immunosuppressed patients. The recent identification of a novel polyomavirus associated with the tumor has stimulated renewed interest in its pathogenesis. MCC tends to show classic histologic features of a neuroendocrine carcinoma and is often positive for CK20, but nonclassic cytologic findings and unusual immunophenotypes may be observed and can lead to a diagnostic confusion. MCC needs to be distinguished from other primary cutaneous tumors with a small cell appearance and metastatic tumors. Surgical excision is the treatment of choice, but radiation therapy has also found to be effective. Sentinel lymph node biops... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481632 Fri, 01 May 2009 04:00:00 +0100 2481632 http://www.medworm.com/index.php?rid=2481644&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F03000%2FCalretinin__Diagnostic_Utility_in_the_Female.5.aspx The utility of calretinin was first described in the diagnosis of mesothelioma. In the female genital tract, calretinin was initially reported in Wolffian remnants and related lesions and later used in the diagnosis of sex cord stromal tumors of the ovary, endometrial stromal tumors with sex cord-like differentiation, and uterine tumors resembling sex cord tumors of the ovary. This review discusses calretinin expression in normal tissues of the female genital tract and highlights its potential utility in the diagnosis of these subsets of neoplasms with emphasis to tumors that may constitute a problem in their differential diagnosis. In particular, the limited utility of calretinin in the diagnosis of sex cord stromal tumors of the ovary, in the differential diagnosis between mesothelioma a... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481644 Sun, 01 Mar 2009 05:00:00 +0100 2481644 http://www.medworm.com/index.php?rid=2481643&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F03000%2FGlypican_3__A_Novel_Diagnostic_Marker_for.6.aspx This article reviews the current information on the application of GPC3 immunostaining in surgical pathology and cytology. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481643 Sun, 01 Mar 2009 05:00:00 +0100 2481643 http://www.medworm.com/index.php?rid=2481642&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F03000%2FPathology_and_the_Internet__Henry_Stewart_Talks.7.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481642 Sun, 01 Mar 2009 05:00:00 +0100 2481642 http://www.medworm.com/index.php?rid=2481640&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F03000%2FPathologic_Features_and_Biologic_Importance_of.2.aspx Serrated polyps of the large intestine comprise a heterogeneous group of mucosal lesions that includes nondysplastic polyps, such as hyperplastic polyps and sessile serrated polyps, and polyps that show overt cytologic dysplasia, namely serrated adenomas and mixed hyperplastic/adenomatous polyps. These polyps have received increased recognition over the past 2 decades, as emerging evidence suggests that a subset may be precursors to colorectal carcinomas that lack chromosomal instability. Several investigators have proposed the concept of the "serrated neoplastic pathway" according to which nondysplastic serrated lesions develop progressively severe dysplasia culminating in the development of microsatellite unstable carcinomas that show DNA hypermethylation and BRAF mutations. A subset of ... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481640 Sun, 01 Mar 2009 05:00:00 +0100 2481640 http://www.medworm.com/index.php?rid=2481635&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F03000%2FUtility_of_Diagnostic_and_Prognostic_Markers_in.1.aspx Urothelial carcinoma (UCC) of the bladder demonstrates diverse morphologic features, often leading to diagnostic challenges in the discrimination between UCC and benign mimickers of neoplasia, and between primary UCC and secondary neoplasms involving the bladder. In situ lesions also provide diagnostic difficulty in some instances, most prominently in the distinction between normal, reactive urothelium and flat urothelial carcinoma in situ. The use of ancillary techniques, including panels of immunohistochemical markers, in distinguishing these entities has aided not only in the diagnosis of UCC, but has also provided insight into the molecular pathogenesis and prognostic value of numerous molecular pathways in UCC. This review focuses on some of the more commonly encountered biomarkers in... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2481635 Sun, 01 Mar 2009 05:00:00 +0100 2481635 http://www.medworm.com/index.php?rid=3073645&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F03000%2FUrologic_Pathology_3rd_Ed.8.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073645 Sun, 01 Mar 2009 00:00:00 +0100 3073645 http://www.medworm.com/index.php?rid=2932992&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F03000%2FCarcinomas_of_the_Upper_Aerodigestive_Tract_With.3.aspx This manuscript reviews carcinomas of the upper aerodigestive tract associated with genetic rearrangements of the nuclear protein of the testis (NUT) gene, also known as NUT midline carcinomas. The literature is reviewed regarding all reported cases of NUT midline carcinomas and the clinicopathologic features are discussed. Our current understanding of the molecular pathogenesis of the disease is also discussed, along with the differential diagnosis for undifferentiated or poorly differentiated malignancy of the upper aerodigestive tract. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2932992 Sun, 01 Mar 2009 00:00:00 +0100 2932992 http://www.medworm.com/index.php?rid=2204674&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200903000-00010.htm Page: 134DOI: 10.1097/PAP.0b013e31819ec9fd (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2204674 Sun, 22 Feb 2009 14:06:36 +0100 2204674 http://www.medworm.com/index.php?rid=2204673&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200903000-00009.htm Page: 133DOI: 10.1097/PAP.0b013e318199799dAuthors: Batsakis, John G. MD *; Ayala, Alberto MD +; El Naggar, Adel K. MD, PhD * (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2204673 Sun, 22 Feb 2009 14:06:36 +0100 2204673 http://www.medworm.com/index.php?rid=2204672&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200903000-00008.htm Page: 132DOI: 10.1097/PAP.0b013e3181992440Authors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2204672 Sun, 22 Feb 2009 14:06:36 +0100 2204672 http://www.medworm.com/index.php?rid=2204671&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200903000-00007.htm Page: 130DOI: 10.1097/PAP.0b013e3181992469Authors: Wheeler, Darren MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2204671 Sun, 22 Feb 2009 14:06:36 +0100 2204671 http://www.medworm.com/index.php?rid=2204670&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200903000-00006.htm Page: 125DOI: 10.1097/PAP.0b013e3181992455Authors: Kandil, Dina H. MD; Cooper, Kumarasen MBChB, DPhil, FRCPath (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2204670 Sun, 22 Feb 2009 14:06:36 +0100 2204670 http://www.medworm.com/index.php?rid=2204669&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200903000-00005.htm Page: 118DOI: 10.1097/PAP.0b013e31819923ceAuthors: Portugal, Raquel MD; Oliva, Esther MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2204669 Sun, 22 Feb 2009 14:06:36 +0100 2204669 http://www.medworm.com/index.php?rid=2204668&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200903000-00004.htm Page: 97DOI: 10.1097/PAP.0b013e31819946aaAuthors: Gao, Zu-hua MD, PhD, FRCPC (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2204668 Sun, 22 Feb 2009 14:06:36 +0100 2204668 http://www.medworm.com/index.php?rid=2204667&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200903000-00003.htm Page: 92DOI: 10.1097/PAP.0b013e31819923e4Authors: Stelow, Edward B. MD *; French, Christopher A. MD + (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2204667 Sun, 22 Feb 2009 14:06:36 +0100 2204667 http://www.medworm.com/index.php?rid=2204666&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200903000-00002.htm Page: 79DOI: 10.1097/PAP.0b013e31819923b3Authors: Vakiani, Efsevia MD, PhD *; Yantiss, Rhonda K. MD + (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2204666 Sun, 22 Feb 2009 14:06:36 +0100 2204666 http://www.medworm.com/index.php?rid=2204665&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200903000-00001.htm Page: 67DOI: 10.1097/PAP.0b013e318199f89eAuthors: Coleman, Joshua F. MD; Hansel, Donna E. MD, PhD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2204665 Sun, 22 Feb 2009 00:55:25 +0100 2204665 http://www.medworm.com/index.php?rid=2714397&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F01000%2FLupus_Mastitis__A_Clinicopathologic_Review_and.5.aspx Lupus mastitis (LM) is a rare presentation of lupus erythematosus profundus or lupus panniculitis, an unusual and rare clinical variant of lupus erythematosus itself in which the inflammatory reaction occurs primarily in the deep subcutaneous adipose. Although not required for diagnosis, essentially all cases of LM present with systemic or discoid lupus. The etiology is uncertain. Histologically it is defined by a lymphocytic lobular panniculitis and a characteristic hyaline sclerosis of the adipose tissue. Treatment is primarily medical due to exacerbation of disease by surgical intervention. A high index of suspicion, and familiarity of the histologic findings, is therefore required to make an accurate diagnosis and prevent further unwarranted diagnostic procedures. Herein, we provide a ... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2714397 Thu, 01 Jan 2009 00:00:00 +0100 2714397 http://www.medworm.com/index.php?rid=2493833&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F01000%2FThe_Expanding_Family_of_Glioneuronal_Tumors.3.aspx Three new entities have been recently added to the group of glioneuronal tumors in the most recent update of the World Health Organization classification of tumors of the central nervous system: papillary glioneuronal tumor, rosetted glioneuronal tumor with neuropil-like islands, and rosette-forming glioneuronal tumor of the fourth ventricle. These tumors are relatively infrequent lesions, and because of that, they can be challenging to diagnose for the practicing pathologist. In this article, we summarize the clinical and pathologic findings of these new lesions. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493833 Thu, 01 Jan 2009 00:00:00 +0100 2493833 http://www.medworm.com/index.php?rid=2493828&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F01000%2FMolecular_Alterations_in_Hereditary_and_Sporadic.2.aspx Thyroid and parathyroid diseases are fairly common and can be either hereditary or sporadic in nature. Tumors and tumor-like processes account for the majority of surgical pathology specimens in both of these endocrine organs. Molecular alterations are well known to occur in both the hereditary and the sporadic settings, and include alterations in tumor suppressor genes and oncogenes. The genetic pathways of tumors of parathyroid and thyroid are beginning to be well understood and are proving to be useful diagnostic, prognostic, and potential therapeutic targets. The molecular alterations in parathyroid and thyroid tumors and tumor-like processes are reviewed, with a focus on the potentially clinically useful diagnostic markers. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Advance... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493828 Thu, 01 Jan 2009 00:00:00 +0100 2493828 http://www.medworm.com/index.php?rid=2493822&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F01000%2FEpstein_Barr_Virus_in_Lymphoproliferative.4.aspx The Epstein-Barr virus is an orally transmitted herpesvirus that is widespread in human populations and exhibits marked B-cell tropism. It is associated with more human neoplasms than any other known virus, and its role in the pathogenesis of such neoplasms has been the subject of intense investigation. This review presents an overview and update of the biology of Epstein-Barr virus and the diagnostic features of lymphoproliferative disorders associated with this intriguing human pathogen. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493822 Thu, 01 Jan 2009 00:00:00 +0100 2493822 http://www.medworm.com/index.php?rid=2493805&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F01000%2FD2_40_Immunohistochemistry_So_Far_.6.aspx D2-40 is a commercially available monoclonal antibody directed against human podoplanin, a transmembrane mucoprotein that is expressed in lymphatic endothelial cells. Since its introduction, D2-40 immunoexpression has been described in a variety of lymphovascular neoplasms including lymphangioma, Kaposi sarcoma, and hemangioendothelioma, as well as nonvascular neoplasms such as epithelioid mesothelioma, seminoma, and hemangioblastoma. More recently, D2-40 immunoexpression has been reported in primary adrenal cortical tumors, schwannomas, and adnexal tumors of the skin. This brief review provides an update on the everexpanding proposed applications of D2-40 immunohistochemistry in surgical pathology. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493805 Thu, 01 Jan 2009 00:00:00 +0100 2493805 http://www.medworm.com/index.php?rid=2493804&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2009%2F01000%2FLow_grade_Endometrial_Adenocarcinoma__A_Diagnostic.1.aspx The distinction between endometrial hyperplasia and well-differentiated adenocarcinoma of the endometrium continues to be a difficult differential diagnosis in surgical pathology. Evidence-based diagnostic criteria for well-differentiated endometrial adenocarcinoma focus on histologic features that predict myoinvasion in the hysterectomy specimen. Only 2 diagnostic criteria with significant power aid in this distinction: complex glandular architectural patterns (glandular confluence, intraglandular complexity, and hierarchical papillary architecture) and marked cytologic atypia beyond that typically defined as atypical hyperplasia (ie, prominent macronucleoli visible at low power and marked nuclear pleomorphism). Application of these 2 criteria in problematic endometrial proliferations all... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493804 Thu, 01 Jan 2009 00:00:00 +0100 2493804 http://www.medworm.com/index.php?rid=2052264&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200901000-00007.htm Page: 65DOI: 10.1097/PAP.0b013e3181916017Authors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2052264 Sat, 20 Dec 2008 09:45:36 +0100 2052264 http://www.medworm.com/index.php?rid=2052263&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200901000-00006.htm Page: 62DOI: 10.1097/PAP.0b013e3181915e94Authors: Kalof, Alexandra N. MD; Cooper, Kumarasen MBChB, DPhil, FRCPath (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2052263 Sat, 20 Dec 2008 09:45:36 +0100 2052263 http://www.medworm.com/index.php?rid=2052262&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200901000-00005.htm Page: 56DOI: 10.1097/PAP.0b013e3181915ff7Authors: Summers, Thomas A. Jr MD *; Lehman, Michael B. MD +; Barner, Ross MD *; Royer, Michael C. MD * (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2052262 Sat, 20 Dec 2008 09:45:36 +0100 2052262 http://www.medworm.com/index.php?rid=2052261&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200901000-00004.htm Page: 40DOI: 10.1097/PAP.0b013e3181916029Authors: Ng, Siok-Bian MBBS *; Khoury, Joseph D. MD + (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2052261 Sat, 20 Dec 2008 09:45:36 +0100 2052261 http://www.medworm.com/index.php?rid=2052260&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200901000-00003.htm Page: 33DOI: 10.1097/PAP.0b013e3181915e3bAuthors: Allende, Daniela S. MD; Prayson, Richard A. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2052260 Sat, 20 Dec 2008 09:45:36 +0100 2052260 http://www.medworm.com/index.php?rid=2052259&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200901000-00002.htm Page: 23DOI: 10.1097/PAP.0b013e3181915f7dAuthors: Hunt, Jennifer L. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2052259 Sat, 20 Dec 2008 09:45:36 +0100 2052259 http://www.medworm.com/index.php?rid=2052258&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200901000-00001.htm Page: 1DOI: 10.1097/PAP.0b013e3181919e15Authors: McKenney, Jesse K. MD; Longacre, Teri A. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2052258 Sat, 20 Dec 2008 00:40:30 +0100 2052258 http://www.medworm.com/index.php?rid=2514221&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F11000%2FAtypical_Fibroxanthoma__An_Immunohistochemistry.6.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2514221 Sat, 01 Nov 2008 00:00:00 +0100 2514221 http://www.medworm.com/index.php?rid=2493835&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F11000%2FHepatic_Granulomas%2C_With_an_Emphasis_on_Infectious.1.aspx Granulomas are aggregates of macrophages, often admixed with other inflammatory cells, which usually result from chronic antigen presentation. Many diseases that produce granulomas involve the liver. Some are intrinsic hepatic diseases, whereas others are disseminated systemic diseases that involve the liver and other organs. Hepatic granulomas are reportedly present in 2% to 10% of all liver biopsy specimens examined in general practice, and of those supposedly as many as 36% have no discoverable etiology even after extensive evaluation of the specimen. This review focuses on the diagnosis of granulomas in infectious diseases affecting the liver, including use of special stains, serologic studies, and molecular diagnostic techniques, and discusses pertinent noninfectious causes of hepatic... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493835 Sat, 01 Nov 2008 00:00:00 +0100 2493835 http://www.medworm.com/index.php?rid=2493823&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F11000%2FDermatopathology_for_the_Surgical_Pathologist__A.4.aspx The accurate diagnosis of inflammatory conditions in dermatopathology requires integrating the histopathologic findings with the clinical features. This second part of a 2-part review of inflammatory cutaneous conditions presents a pattern-based approach to the diagnosis of dermatologic disorders and reviews the salient clinical and histologic features. (C) 2008 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493823 Sat, 01 Nov 2008 00:00:00 +0100 2493823 http://www.medworm.com/index.php?rid=2493806&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F11000%2FMolecular_Alterations_in_Prostate_Cancer_as.2.aspx Prostatic adenocarcinoma is extremely common in Western nations, representing the second leading cause of cancer death in American men. The recent application of increasingly sophisticated molecular approaches to the study of prostate cancer in this "postgenomic" era has resulted in a rapid increase in the identification of somatic genome alterations and germline heritable risk factors in this disease. These findings are leading to a new understanding of the pathogenesis of prostate cancer and to the generation of new targets for diagnosis, prognosis, and prediction of therapeutic response. Although we are still in the very early phase of clinical development, some of the molecular alterations identified in prostate cancer are being translated into clinical practice. The purpose of this re... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493806 Sat, 01 Nov 2008 00:00:00 +0100 2493806 http://www.medworm.com/index.php?rid=1900994&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200811000-00009.htm Page: 377DOI: 10.1097/PAP.0b013e31818a645cAuthors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1900994 Fri, 24 Oct 2008 11:02:40 +0100 1900994 http://www.medworm.com/index.php?rid=1900993&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200811000-00008.htm Page: 376DOI: 10.1097/01.pap.0000338884.56461.eeAuthors: Allen, Philip W. MB, BS, FRCPA (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1900993 Fri, 24 Oct 2008 11:02:40 +0100 1900993 http://www.medworm.com/index.php?rid=1900992&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200811000-00007.htm Page: 376DOI: 10.1097/PAP.0b013e31818b2076Authors: Gonzalez, Sergio MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1900992 Fri, 24 Oct 2008 11:02:40 +0100 1900992 http://www.medworm.com/index.php?rid=1900991&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200811000-00006.htm Page: 374DOI: 10.1097/PAP.0b013e31818a64d3Authors: Greene, Laura A. MD; Cooper, Kumarasen MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1900991 Fri, 24 Oct 2008 11:02:40 +0100 1900991 http://www.medworm.com/index.php?rid=1900990&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200811000-00005.htm Page: 370DOI: 10.1097/PAP.0b013e31818a64e5Authors: Jaffer, Shabnam MD; Nagi, Chandandeep MD; Bleiweiss, Ira J. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1900990 Fri, 24 Oct 2008 11:02:40 +0100 1900990 http://www.medworm.com/index.php?rid=1900989&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200811000-00004.htm Page: 350DOI: 10.1097/PAP.0b013e31818b1ac6Authors: Brinster, Nooshin K. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1900989 Fri, 24 Oct 2008 11:02:40 +0100 1900989 http://www.medworm.com/index.php?rid=1900988&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200811000-00003.htm Page: 332DOI: 10.1097/PAP.0b013e31818a64afAuthors: Dotto, Jorge MD * + ++; Nose, Vania MD, PhD + ++ (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1900988 Fri, 24 Oct 2008 11:02:40 +0100 1900988 http://www.medworm.com/index.php?rid=1900987&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200811000-00002.htm Page: 319DOI: 10.1097/PAP.0b013e31818a5c19Authors: Gurel, Bora MD *; Iwata, Tsuyoshi MD *; Koh, Cheryl M. BS *; Yegnasubramanian, Srinivasan MD, PhD + ++; Nelson, William G. MD, PhD * + ++ [S] [//]; De Marzo, Angelo M. MD, PhD * + ++ [S] [//] (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1900987 Fri, 24 Oct 2008 11:02:40 +0100 1900987 http://www.medworm.com/index.php?rid=1900986&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200811000-00001.htm Page: 309DOI: 10.1097/PAP.0b013e31818a6477Authors: Lamps, Laura W. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1900986 Thu, 23 Oct 2008 23:55:29 +0100 1900986 http://www.medworm.com/index.php?rid=3161950&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F09000%2FRosai_and_Ackerman_s_Surgical_Pathology_Review.12.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3161950 Mon, 01 Sep 2008 00:00:00 +0100 3161950 http://www.medworm.com/index.php?rid=2680409&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F09000%2FGray_Zones_in_Brain_Tumor_Classification__Evolving.4.aspx The World Health Organization recently updated its classification of central nervous system tumors, adding 8 entities, as well as defining new variants and morphologic patterns of existing entities. Despite the continued refinement of brain tumor histologic classification and grading, there remain some diagnostic "gray zones" that challenge general surgical pathologists and neuropathologists alike. These include the presence of oligodendroglial features in (mixed) oligoastrocytomas and glioblastomas (GBMs), GBM variants (such as small cell GBM), meningioma classification and grading, medulloblastoma variants, ependymoma grading, the presence of "neuronal features" in otherwise morphologically classic gliomas, and low-grade gliomas with high Ki-67 labeling indices. In the current review, we... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2680409 Sun, 31 Aug 2008 23:00:00 +0100 2680409 http://www.medworm.com/index.php?rid=2600053&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F09000%2FDiagnostic%2C_Theranostic%2C_and_Genomic.8.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2600053 Sun, 31 Aug 2008 23:00:00 +0100 2600053 http://www.medworm.com/index.php?rid=2493829&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F09000%2FDiagnostic_Problems_in_Anal_Pathology.2.aspx Anal squamous cell carcinoma and its precursor lesions are increasing in incidence in the United States and Europe. This trend predates human immunodeficiency virus/acquired immune deficiency syndrome and has been associated with persistent high-risk human papilloma virus (HPV) genotype infection, previous lower genital tract dysplasia/carcinoma, high frequency anoreceptive intercourse, heavy cigarette smoking, immunosuppression in solid organ transplant and immune disorders, and human immunodeficiency virus seropositivity. Screening protocols for at-risk patients are under active investigation and pathologists are often asked to assess anal canal and perianal biopsies for the presence of dysplasia and/or invasive carcinoma. Because underdiagnosis and overdiagnosis of anal cancer and preca... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493829 Sun, 31 Aug 2008 23:00:00 +0100 2493829 http://www.medworm.com/index.php?rid=2493808&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F09000%2FBladder_Cancer_Detection_Using_FISH__UroVysion.3.aspx UroVysion is a fluorescence in situ hybridization assay that was developed for the detection of bladder cancer in urine specimens. It consists of fluorescently labeled DNA probes to the pericentromeric regions of chromosomes 3 (red), 7 (green), and 17 (aqua) and to the 9p21 band (gold) location of the P16 tumor suppressor gene. The UroVysion assay works by detecting urinary cells that have chromosomal abnormalities consistent with a diagnosis of bladder cancer. Studies have shown that UroVysion is more sensitive than urine cytology for the detection of all stages and grades of bladder cancer. UroVysion is Food and Drug Administration-approved for the detection of recurrent bladder cancer in voided urine specimens from patients with a history of bladder cancer and for the detection of bladd... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493808 Sun, 31 Aug 2008 23:00:00 +0100 2493808 http://www.medworm.com/index.php?rid=1725950&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00012.htm Page: 308DOI: 10.1097/PAP.0b013e31818322fbAuthors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725950 Sat, 23 Aug 2008 10:10:11 +0100 1725950 http://www.medworm.com/index.php?rid=1725949&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00011.htm Page: 307DOI: 10.1097/PAP.0b013e318183230dAuthors: Hoda, Syed A. MD; Brandt, Suzanne M. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725949 Sat, 23 Aug 2008 10:10:11 +0100 1725949 http://www.medworm.com/index.php?rid=1725948&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00010.htm Page: 306DOI: 10.1097/PAP.0b013e31818322e9Authors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725948 Sat, 23 Aug 2008 10:10:11 +0100 1725948 http://www.medworm.com/index.php?rid=1725947&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00009.htm Page: 304DOI: 10.1097/PAP.0b013e3181832381Authors: Bhargava, Rohit MD; Chivukula, Mamatha MD; Beriwal, Sushil MD; Dabbs, David J. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725947 Sat, 23 Aug 2008 10:10:11 +0100 1725947 http://www.medworm.com/index.php?rid=1725946&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00008.htm Page: 302DOI: 10.1097/PAP.0b013e3181832392Authors: Chivukula, Mamatha MD; Bhargava, Rohit MD; Dabbs, David J. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725946 Sat, 23 Aug 2008 10:10:11 +0100 1725946 http://www.medworm.com/index.php?rid=1725945&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00007.htm Page: 302DOI: 10.1097/PAP.0b013e31818323ccAuthors: Goldblum, John R. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725945 Sat, 23 Aug 2008 10:10:11 +0100 1725945 http://www.medworm.com/index.php?rid=1725944&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00006.htm Page: 300DOI: 10.1097/PAP.0b013e3181832332Authors: Moore, Brian E. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725944 Sat, 23 Aug 2008 10:10:11 +0100 1725944 http://www.medworm.com/index.php?rid=1725943&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00005.htm Page: 298DOI: 10.1097/PAP.0b013e31818323dcAuthors: Wheeler, Darren MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725943 Sat, 23 Aug 2008 10:10:11 +0100 1725943 http://www.medworm.com/index.php?rid=1725942&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00004.htm Page: 287DOI: 10.1097/PAP.0b013e3181836a03Authors: Trembath, Dimitri MD, PhD *; Miller, Christopher Ryan MD, PhD * +; Perry, Arie MD ++ (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725942 Sat, 23 Aug 2008 10:10:11 +0100 1725942 http://www.medworm.com/index.php?rid=1725941&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00003.htm Page: 279DOI: 10.1097/PAP.0b013e3181832320Authors: Halling, Kevin C. MD, PhD; Kipp, Benjamin R. PhD, MP, CT (ASCP) (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725941 Sat, 23 Aug 2008 10:10:11 +0100 1725941 http://www.medworm.com/index.php?rid=1725940&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00002.htm Page: 263DOI: 10.1097/PAP.0b013e318183234bAuthors: Longacre, Teri A. MD *; Kong, Christina S. MD *; Welton, Mark L. MD + (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725940 Sat, 23 Aug 2008 10:10:11 +0100 1725940 http://www.medworm.com/index.php?rid=1725939&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200809000-00001.htm Page: 253DOI: 10.1097/PAP.0b013e31818323acAuthors: Busam, Klaus J. MD; Pulitzer, Melissa MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1725939 Fri, 22 Aug 2008 23:32:38 +0100 1725939 http://www.medworm.com/index.php?rid=3073661&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F07000%2FBreast_Core_Biopsy__A_Pathologic_Radiologic.9.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073661 Tue, 01 Jul 2008 00:00:00 +0100 3073661 http://www.medworm.com/index.php?rid=2493825&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F07000%2FEGFR_Assays_in_Lung_Cancer.6.aspx The development of small-molecule inhibitors of the epidermal growth factor receptor (EGFR) resulted in new therapeutic options for patients with advanced lung cancer. It was clear from the experience with targeted therapy for breast cancer that a new standardized assay procedure for assessing and predicting the effects of therapeutic agents must be developed. Three academic groups almost simultaneously reported the discovery of somatic mutations in the exons 18 to 21 of the tyrosine kinase (TK) domain of EGFR that correlated with a high likelihood of response to EGFR TK inhibitors. This observation revolutionized understanding of EGFR in lung carcinogenesis and resulted in numerous retrospective studies that correlated patient's response and molecular profile of the lung adenocarcinoma. T... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493825 Mon, 30 Jun 2008 23:00:00 +0100 2493825 http://www.medworm.com/index.php?rid=2493814&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F07000%2FMultiple_Myeloma_and_Immunosecretory_Disorders__An.2.aspx The immunosecretory disorders are a diverse group of diseases associated with proliferation of an abnormal clone of immunoglobulin (Ig)-synthesizing, terminally differentiated B cells. These disorders include multiple myeloma (MM) and its variants, plasmacytoma, Waldenstrom macroglobulinemia, monoclonal gammopathy of undetermined significance, and monoclonal Ig deposition diseases, the latter including primary amyloidosis and nonamyloidotic types. These disorders are histologically composed of plasma cells, or plasmacytoid cells which produce Ig that is synthesized and usually secreted and can be deposited in some diseases. The Ig can be complete or can be composed of either heavy or light chains and is termed M-(monoclonal) protein. In MM, this proliferation overwhelms the normal cellular... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493814 Mon, 30 Jun 2008 23:00:00 +0100 2493814 http://www.medworm.com/index.php?rid=1542433&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200807000-00011.htm Page: 251DOI: 10.1097/PAP.0b013e31817bf539Authors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1542433 Wed, 25 Jun 2008 21:25:56 +0100 1542433 http://www.medworm.com/index.php?rid=1542432&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200807000-00010.htm Page: 250DOI: 10.1097/PAP.0b013e31817bf526Authors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1542432 Wed, 25 Jun 2008 21:25:56 +0100 1542432 http://www.medworm.com/index.php?rid=1542431&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200807000-00009.htm Page: 249DOI: 10.1097/PAP.0b013e31817bf514Authors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1542431 Wed, 25 Jun 2008 21:25:56 +0100 1542431 http://www.medworm.com/index.php?rid=1542430&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200807000-00008.htm Page: 248DOI: 10.1097/PAP.0b013e31817bf54bAuthors: Baloch, Zubair W. MD, PhD; LiVolsi, Virginia A. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1542430 Wed, 25 Jun 2008 21:25:56 +0100 1542430 http://www.medworm.com/index.php?rid=1542429&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200807000-00007.htm Page: 248DOI: 10.1097/PAP.0b013e31817bf4feAuthors: Kessler, Thomas MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1542429 Wed, 25 Jun 2008 21:25:56 +0100 1542429 http://www.medworm.com/index.php?rid=1542428&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200807000-00006.htm Page: 241DOI: 10.1097/PAP.0b013e31817bf5a9Authors: Dacic, Sanja MD, PhD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1542428 Wed, 25 Jun 2008 21:25:56 +0100 1542428 http://www.medworm.com/index.php?rid=1542427&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200807000-00005.htm Page: 234DOI: 10.1097/PAP.0b013e31817bf566Authors: Chetty, Runjan MB, BCh, FRCPath, FRCPC, DPhil; Serra, Stefano MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1542427 Wed, 25 Jun 2008 21:25:56 +0100 1542427 http://www.medworm.com/index.php?rid=1542426&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200807000-00004.htm Page: 218DOI: 10.1097/PAP.0b013e31817d79b9Authors: Nigwekar, Priya MD; Amin, Mahul B. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1542426 Wed, 25 Jun 2008 21:25:56 +0100 1542426 http://www.medworm.com/index.php?rid=1542425&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200807000-00003.htm Page: 211DOI: 10.1097/PAP.0b013e31817bf596Authors: Hunt, Jennifer L. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1542425 Wed, 25 Jun 2008 21:25:56 +0100 1542425 http://www.medworm.com/index.php?rid=1542424&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200807000-00002.htm Page: 196DOI: 10.1097/PAP.0b013e31817cfcd6Authors: Shaheen, Saad P. MD *; Talwalkar, Sameer S. MD +; Medeiros, L. Jeffrey MD + (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1542424 Wed, 25 Jun 2008 21:25:56 +0100 1542424 http://www.medworm.com/index.php?rid=1542423&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200807000-00001.htm Page: 185DOI: 10.1097/PAP.0b013e31817bf57dAuthors: Shi, Chanjuan MD, PhD *; Daniels, Jason A. MD *; Hruban, Ralph H. MD * + (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1542423 Tue, 24 Jun 2008 23:39:41 +0100 1542423 http://www.medworm.com/index.php?rid=3226213&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F05000%2FDiagnostic_Histopathology_of_Tumors%2C_3rd_Edition.11.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3226213 Thu, 01 May 2008 00:00:00 +0100 3226213 http://www.medworm.com/index.php?rid=3073638&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F05000%2FCytopathologic_Diagnosis_of_Serous_Fluids.9.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073638 Thu, 01 May 2008 00:00:00 +0100 3073638 http://www.medworm.com/index.php?rid=3037982&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F05000%2FThe__Rosen_Triad___Tubular_Carcinoma%2C_Lobular.2.aspx The histologic triad of tubular carcinoma (TC), columnar cell lesion (CCL), and lobular carcinoma in situ (LCIS) has been recognized, but has not yet been fully characterized. The "Rosen Triad"-named in tribute to its first categorical description by the eponymous pathologist-is a morphologic observation that may have important clinical and pathologic implications. To study these implications, the literature on the topic was reviewed. Our own institution's experience with this triad was also reviewed via a study of clinicopathologic material from all TCs diagnosed at excision during a 5-year period (2001 to 2006). The diagnosis of TC was confirmed in 86 of our cases, and relevant patient data were analyzed. TC was associated with some degree of CCL in all (100%, 86/86) cases and with LCIS ... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3037982 Thu, 01 May 2008 00:00:00 +0100 3037982 http://www.medworm.com/index.php?rid=2493834&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F05000%2FNeoplasms_of_the_Upper_Urinary_Tract__A_Review.1.aspx Tumors of the renal pelvis account for approximately 7% to 8% of all renal malignancies, greater than 90% of these are of urothelial (transitional cell) origin. These tumors more typically occur in the sixth to eight decade with a slight male preponderance. Varying risk factors for urothelial carcinomas of the upper tract are recognized including environmental and occupational hazards, chemotherapeutic exposure, and previous history of urinary bladder or ureteral carcinomas. Tumor multifocality is frequent and additional tumors may arise in the ureter, bladder, or on the contralateral side. The histopathologic nuances presented by urothelial carcinoma in this region are generally similar to those in the urinary bladder. Though the World Health Organization 2004/International Society of Uro... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493834 Wed, 30 Apr 2008 23:00:00 +0100 2493834 http://www.medworm.com/index.php?rid=2493809&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F05000%2FThe_Normal_and_Neoplastic_Perineurium__A_Review.3.aspx Peripheral nerves consist of 3 layers with differing characteristics: the endoneurium, perineurium, and epineurium. The perineurium represents a continuum with the pia-arachnoid from the central nervous system and extends distally with the sheath of capsular cells of peripheral sensorial organs and propioceptive receptors. It is made of layers of flattened cells surrounded by a basement membrane and collagen fibers, forming concentrically laminated structures around single nerve fascicles. Functionally, the perineurium modulates external stretching forces (that could be potentially harmful for nerve fibers), and along with endoneurial vessels, forms the blood-nerve barrier. Multiple pathologic conditions associated with the perineurium have been described. Perineurial invasion is considere... Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=2493809 Wed, 30 Apr 2008 23:00:00 +0100 2493809 http://www.medworm.com/index.php?rid=1394960&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200805000-00011.htm Page: 183DOI: 10.1097/PAP.0b013e3181709f70Authors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1394960 Thu, 24 Apr 2008 08:44:35 +0100 1394960 http://www.medworm.com/index.php?rid=1394959&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200805000-00010.htm Page: 182DOI: 10.1097/PAP.0b013e3181709f5dAuthors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1394959 Thu, 24 Apr 2008 08:44:35 +0100 1394959 http://www.medworm.com/index.php?rid=1394958&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200805000-00009.htm Page: 181DOI: 10.1097/PAP.0b013e31817150adAuthors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1394958 Thu, 24 Apr 2008 08:44:35 +0100 1394958 http://www.medworm.com/index.php?rid=1394957&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200805000-00008.htm Page: 179DOI: 10.1097/PAP.0b013e3181709f83Authors: Mangray, Shamlal MD; DeLellis, Ronald A. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1394957 Thu, 24 Apr 2008 08:44:35 +0100 1394957 http://www.medworm.com/index.php?rid=1394956&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200805000-00007.htm Page: 179DOI: 10.1097/PAP.0b013e3181709f47Authors: Marcocci, Claudio MD; Cetani, Filomena MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1394956 Thu, 24 Apr 2008 08:44:35 +0100 1394956 http://www.medworm.com/index.php?rid=1394955&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200805000-00006.htm Page: 177DOI: 10.1097/PAP.0b013e3181709f94Authors: Wheeler, Darren MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1394955 Thu, 24 Apr 2008 08:44:35 +0100 1394955 http://www.medworm.com/index.php?rid=1394954&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200805000-00005.htm Page: 172DOI: 10.1097/PAP.0b013e3181709fa7Authors: Allen, Philip W. MB, BS, FRCPA (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1394954 Thu, 24 Apr 2008 08:44:35 +0100 1394954 http://www.medworm.com/index.php?rid=1394953&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200805000-00004.htm Page: 165DOI: 10.1097/PAP.0b013e31816f852eAuthors: Shehata, Bahig M. MD * +; Stockwell, Christina A. BA *; Castellano-Sanchez, Amilcar A. MD +; Setzer, Shannon MD ++; Schmotzer, Christine L. MD +; Robinson, Haynes MD [S] (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1394953 Thu, 24 Apr 2008 08:44:35 +0100 1394953 http://www.medworm.com/index.php?rid=1394952&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200805000-00003.htm Page: 147DOI: 10.1097/PAP.0b013e31816f8519Authors: Pina-Oviedo, Sergio MD * +; Ortiz-Hidalgo, Carlos MD * ++ (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1394952 Thu, 24 Apr 2008 08:44:35 +0100 1394952 http://www.medworm.com/index.php?rid=1394951&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200805000-00002.htm Page: 140DOI: 10.1097/PAP.0b013e31816ff313Authors: Brandt, Suzanne M. MD; Young, Gloria Q. MD; Hoda, Syed A. MD (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1394951 Thu, 24 Apr 2008 08:44:35 +0100 1394951 http://www.medworm.com/index.php?rid=1394950&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fwww.anatomicpathology.com%2Fpt%2Fre%2Faapath%2Fabstract.00125480-200805000-00001.htm Page: 127DOI: 10.1097/PAP.0b013e31817145a9Authors: Gupta, Ruta MD *; Paner, Gladell P. MD +; Amin, Mahul B. MD * (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=1394950 Thu, 24 Apr 2008 00:38:36 +0100 1394950 http://www.medworm.com/index.php?rid=3073656&cid=s_34229_32_f&fid=34229&url=http%3A%2F%2Fjournals.lww.com%2Fanatomicpathology%2FFulltext%2F2008%2F03000%2FHistology_for_Pathologists.11.aspx No abstract available (Source: Advances in Anatomic Pathology) Advances in Anatomic Pathology journals http://www.medworm.com/rss/comments.php?id=3073656 Sat, 01 Mar 2008 00:00:00 +0100 3073656