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        <title>Advances in Enzyme Regulation via MedWorm.com</title>
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            <title>Insights into the differences between the A- and B-type nuclear lamins.</title>
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            <description>Authors: Adam SA, Goldman RD
    PMID: 22119859 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Fri, 18 Nov 2011 05:00:00 +0100</pubDate>
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            <title>Roles for nucleotide phosphatases in sulfate assimilation and skeletal disease.</title>
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            <description>Authors: Hudson BH, York JD
    PMID: 22100882 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Sat, 12 Nov 2011 05:00:00 +0100</pubDate>
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            <title>The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death.</title>
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            <description>Authors: Majerus PW, Zou J, Wilson DB, Schrade A, Chang SC, Wilson MP
    PMID: 22056831 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Mon, 24 Oct 2011 04:00:00 +0100</pubDate>
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            <title>Achieving specificity in Akt signaling in cancer.</title>
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            <description>Authors: Toker A
    PMID: 21986444 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <title>PI3K/AKT/mTORC1 and MEK/ERK signaling in T-cell acute lymphoblastic leukemia: New options for targeted therapy.</title>
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            <description>Authors: Martelli AM, Tabellini G, Ricci F, Evangelisti C, Chiarini F, Bortul R, McCubrey JA, Manzoli FA
    PMID: 21983557 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Sat, 01 Oct 2011 04:00:00 +0100</pubDate>
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            <title>Regulation of proliferation, survival, differentiation, and activation by the Signaling Platform for SHP-1 phosphatase.</title>
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            <description>Authors: Kawakami T, Xiao W, Yasudo H, Kawakami Y
    PMID: 21982978 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <title>Revisiting nuclear phospholipase C signalling in MDS.</title>
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    PMID: 21982979 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <title>Diverse cellular and physiological roles of phospholipase C-γ1.</title>
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            <description>Authors: Yang YR, Choi JH, Chang JS, Kwon HM, Jang HJ, Ryu SH, Suh PG
    PMID: 21964416 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <title>Truth and consequences of sphingosine-1-phosphate lyase.</title>
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            <description>Authors: Aguilar A, Saba JD
    PMID: 21946005 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Sat, 17 Sep 2011 04:00:00 +0100</pubDate>
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            <title>Regulation and functions of the lipid kinase PIP5K γ661 at synapses.</title>
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            <description>Authors: Kanaho Y, Unoki T
    PMID: 21945523 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <title>The activity, evolution and association of phosphatidylinositol 5-phosphate 4-kinases.</title>
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            <description>Authors: Clarke JH, Irvine RF
    PMID: 21945524 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Fri, 16 Sep 2011 04:00:00 +0100</pubDate>
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            <title>Essential role of PIKE GTPases in neuronal protection against excitotoxic insults.</title>
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            <description>Authors: Chan CB, Liu X, Chen Y, Papale L, Escayg A, Mei L, Ye K
    PMID: 21925531 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Mon, 12 Sep 2011 04:00:00 +0100</pubDate>
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            <title>Loss of Akt1 evokes epithelial-mesenchymal transition by autocrine regulation of transforming growth factor-β1.</title>
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            <description>Authors: Kim EK, Yun SJ, Ha JM, Kim YW, Jin IH, Woo DH, Song SH, Ha HK, Choi YS, Lee TG, Bae SS
    PMID: 21925532 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Mon, 12 Sep 2011 04:00:00 +0100</pubDate>
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            <title>Novel approaches to target cancer initiating cells-Eliminating the root of the cancer.</title>
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            <description>Authors: McCubrey JA, Abrams SL, Umezawa K, Cocco L, Martelli AM, Franklin RA, Chappell WH, Steelman LS
    PMID: 21930143 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Mon, 12 Sep 2011 04:00:00 +0100</pubDate>
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            <title>Role of the C-terminal regulatory domain in the allosteric inhibition of PKB/Akt.</title>
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            <description>Authors: Calleja V, Laguerre M, Larijani B
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            <title>Second basic pockets contribute to the localization of PX domains by binding to phosphatidic acid.</title>
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            <description>Authors: Takeuchi H, Zhang Z, Gao J, Sugiyama G, Takeuchi T, Hirata M
    PMID: 21930145 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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    PMID: 21070803 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <description>Authors: Gallego-Ortega D, Gómez Del Pulgar T, Valdés-Mora F, Cebrián A, Lacal JC
    
    PMID: 21035492 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <title>Diphosphoinositol polyphosphates: What are the mechanisms?</title>
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            <description>Authors: Shears SB, Gokhale NA, Wang H, Zaremba A
    
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            <description>Authors: Jhanwar-Uniyal M, Albert L, McKenna E, Karsy M, Rajdev P, Braun A, Murali R
    
    PMID: 21035497 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <title>Phospholipase Cδ3 is a novel binding partner of Myosin VI and functions as anchoring of Myosin VI on plasma membrane.</title>
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    Phosphatidylinositide-3-kinases (PI3K) PI3Kα, is a lipid kinase frequently mutated in several cancer types. Under normal physiological conditions it initiates a number of signaling pathways by recruiting other kinases, such as Akt, to the plasma membrane. The mutations observed in tumors increase PI3K kinase activity, leading to increased cell survival, cell motility, cell metabolism, and cell cycle progression. The structure of the complex between the catalytic subunit of PI3Kα, p110α, and a portion of its regulatory subunit, p85α reveals that many of the oncogenic mutations occur at the interfaces between p110α domains and between p110α and p85α domains. At these positions, mutations may disrupt interactions that result in c...</description>
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            <title>Regulation of B cell survival, development and function by inositol 1,4,5-trisphosphate 3-kinase B (Itpkb).</title>
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    PMID: 21035496 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Wed, 27 Oct 2010 00:00:00 +0100</pubDate>
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            <title>The Signaling Role of Inositol Hexakisphosphate Kinases (IP6Ks).</title>
            <link>http://www.medworm.com/index.php?rid=4137963&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21035498%26dopt%3DAbstract</link>
            <description>Authors: Azevedo C, Szijgyarto Z, Saiardi A
    The inert sugar inositol, in its phosphorylated soluble and lipid forms, regulate an astounding number of physiological functions. The already large inositol polyphosphates signaling network is further expanded by the presence of inositol species containing one ore more pyrophosphate moieties. IP(7) or diphosphoinositol pentakisphosphate, the best-characterized inositol pyrophosphate controls many distinct cellular processes, from yeast telomere length to mammalian insulin secretion. We have recently developed a new assay that allows the analysis of inositol pyrophosphates by gel electrophoresis. Using this assay we discovered that the inositol pyrophosphate family is more complex than previously thought, including a growing number of molecul...</description>
            <author>Advances in Enzyme Regulation</author>
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            <pubDate>Wed, 27 Oct 2010 00:00:00 +0100</pubDate>
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        <item>
            <title>The mechanism of contribution of integrin linked kinase (ILK) to epithelial mesenchymal transition (EMT).</title>
            <link>http://www.medworm.com/index.php?rid=4137962&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21035499%26dopt%3DAbstract</link>
            <description>Authors: Gil D, Ciołczyk-Wierzbicka D, Dulińska-Litewka J, Zwawa K, McCubrey JA, Laidler P
    
    PMID: 21035499 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
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            <pubDate>Wed, 27 Oct 2010 00:00:00 +0100</pubDate>
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        <item>
            <title>Identification of Substrates for Cyclin Dependent Kinases.</title>
            <link>http://www.medworm.com/index.php?rid=3141144&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20045433%26dopt%3DAbstract</link>
            <description>Authors: Errico A, Deshmukh K, Tanaka Y, Pozniakovsky A, Hunt T
    Cyclin dependent kinases (CDKs) initiate and regulate cell cycle transitions. Progress through the cell cycle results from the timely activity of cyclin D/ CDK4 to control G1/S-phase, cyclin E/CDK2 and cyclin A/CDK2 to initiate and complete S-phase and cyclins A and B in combination with CDK1 to initiate mitosis. Despite the importance of CDKs, less than 100 substrates have been identified in higher eukaryotes. In this review we describe methods to identify substrates for CDKs in X. laevis and humans. We compare the lists of substrates derived from our substrate screens with those obtained by others in order to assess the efficiency and completeness of our approach to identify physiologically relevant targets. We screened ...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
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            <pubDate>Wed, 30 Dec 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>The architecture of functional neighborhoods within the mammalian cell nucleus.</title>
            <link>http://www.medworm.com/index.php?rid=3049160&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948182%26dopt%3DAbstract</link>
            <description>Authors: Malyavantham KS, Bhattacharya S, Berezney R
    
    PMID: 19948182 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=3049160</comments>
            <pubDate>Fri, 27 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>Protein kinase c-alpha negatively regulates egf-induced Plc-epsilon activity through direct phosphorylation.</title>
            <link>http://www.medworm.com/index.php?rid=3049159&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19948183%26dopt%3DAbstract</link>
            <description>Authors: Yun S, Byun HY, Oh YS, Yang YR, Ryu SH, Suh PG
    
    PMID: 19948183 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=3049159</comments>
            <pubDate>Fri, 27 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>Laminopathies and A-type Lamin-associated Signalling Pathways.</title>
            <link>http://www.medworm.com/index.php?rid=3009193&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19917303%26dopt%3DAbstract</link>
            <description>Authors: Maraldi NM, Lattanzi G, Cenni V, Bavelloni A, Marmiroli S, Manzoli FA
    
    PMID: 19917303 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=3009193</comments>
            <pubDate>Fri, 13 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>The retromer complex.</title>
            <link>http://www.medworm.com/index.php?rid=2985393&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19900471%26dopt%3DAbstract</link>
            <description>Authors: Attar N, Cullen PJ
    
    PMID: 19900471 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=2985393</comments>
            <pubDate>Fri, 06 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.</title>
            <link>http://www.medworm.com/index.php?rid=2978007&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895837%26dopt%3DAbstract</link>
            <description>Authors: McCubrey JA, Abrams SL, Stadelman K, Chappell WH, Lahair M, Franklin RF, Steelman LS
    
    PMID: 19895837 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=2978007</comments>
            <pubDate>Thu, 05 Nov 2009 00:00:00 +0100</pubDate>
            <guid isPermaLink="false">2978007</guid>        </item>
        <item>
            <title>The guanine nucleotide exchange factor (GEF) ect2 is an oncogene in human cancer.</title>
            <link>http://www.medworm.com/index.php?rid=2977999&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19896966%26dopt%3DAbstract</link>
            <description>Authors: Fields AP, Justilien V
    
    PMID: 19896966 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=2977999</comments>
            <pubDate>Thu, 05 Nov 2009 00:00:00 +0100</pubDate>
            <guid isPermaLink="false">2977999</guid>        </item>
        <item>
            <title>The altered metabolism of tumors: HIF-1 and its role in the Warburg effect.</title>
            <link>http://www.medworm.com/index.php?rid=2977998&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19896967%26dopt%3DAbstract</link>
            <description>Authors: Stubbs M, Griffiths JR
    
    PMID: 19896967 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=2977998</comments>
            <pubDate>Thu, 05 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>Phosphatidylinositol 5-phosphate 4-kinases Localization, regulation and function of Type II phosphatidylinositol 5-phosphate 4-kinases.</title>
            <link>http://www.medworm.com/index.php?rid=2977997&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19896968%26dopt%3DAbstract</link>
            <description>Authors: Clarke JH, Wang M, Irvine RF
    
    PMID: 19896968 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=2977997</comments>
            <pubDate>Thu, 05 Nov 2009 00:00:00 +0100</pubDate>
            <guid isPermaLink="false">2977997</guid>        </item>
        <item>
            <title>Phosphatidylinositol 4,5-bisphosphate regulation of SNARE function in membrane fusion mediated by CAPS.</title>
            <link>http://www.medworm.com/index.php?rid=2977996&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19896969%26dopt%3DAbstract</link>
            <description>Authors: James DJ, Khodthong C, Kowalchyk JA, Martin TF
    
    PMID: 19896969 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=2977996</comments>
            <pubDate>Thu, 05 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer.</title>
            <link>http://www.medworm.com/index.php?rid=2978002&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19896493%26dopt%3DAbstract</link>
            <description>Authors: Stein GS, Stein JL, Van Wijnen AJ, Lian JB, Montecino M, Croce CM, Choi JY, Ali SA, Pande S, Hassan MQ, Zaidi SK, Young DW
    
    PMID: 19896493 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=2978002</comments>
            <pubDate>Wed, 04 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>Activation Mechanisms of PIP5K Isozymes by the Small GTPase ARF6.</title>
            <link>http://www.medworm.com/index.php?rid=2978001&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19896494%26dopt%3DAbstract</link>
            <description>Authors: Funakoshi Y, Hasegawa H, Kanaho Y
    
    PMID: 19896494 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
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        <comments>http://www.medworm.com/rss/comments.php?id=2978001</comments>
            <pubDate>Wed, 04 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>Cross talk between phospholipase D and MAP kinases activities.</title>
            <link>http://www.medworm.com/index.php?rid=2978000&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19896495%26dopt%3DAbstract</link>
            <description>Authors: Wakelam MJ, McNee GS, Rudge SA
    
    PMID: 19896495 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
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        <comments>http://www.medworm.com/rss/comments.php?id=2978000</comments>
            <pubDate>Wed, 04 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>Indirect mechanisms of carcinogenesis via downregulation of PTEN function.</title>
            <link>http://www.medworm.com/index.php?rid=2978014&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895830%26dopt%3DAbstract</link>
            <description>Authors: Leslie NR, Spinelli L, Tibarewal P, Zilidis G, Weerasinghe N, Lim JC, Maccario H, Downes CP
    
    PMID: 19895830 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
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        <comments>http://www.medworm.com/rss/comments.php?id=2978014</comments>
            <pubDate>Tue, 03 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>On the reversibility of glutamate dehydrogenase and the source of hyperammonemia in the hyperinsulinism/hyperammonemia syndrome.</title>
            <link>http://www.medworm.com/index.php?rid=2978013&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895831%26dopt%3DAbstract</link>
            <description>Authors: Treberg JR, Brosnan ME, Watford M, Brosnan JT
    
    PMID: 19895831 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
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        <comments>http://www.medworm.com/rss/comments.php?id=2978013</comments>
            <pubDate>Tue, 03 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>Regulation of PTEN in neurons by myosin-based transport mechanisms.</title>
            <link>http://www.medworm.com/index.php?rid=2978012&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895832%26dopt%3DAbstract</link>
            <description>Authors: Kreis P, van Diepen MT, Eickholt BJ
    
    PMID: 19895832 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
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        <comments>http://www.medworm.com/rss/comments.php?id=2978012</comments>
            <pubDate>Tue, 03 Nov 2009 00:00:00 +0100</pubDate>
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            <title>Regulation of SHIP2 function through plasma membrane interaction.</title>
            <link>http://www.medworm.com/index.php?rid=2978011&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895833%26dopt%3DAbstract</link>
            <description>Authors: Deneubourg L, Vanderwinden JM, Erneux C
    
    PMID: 19895833 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
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        <comments>http://www.medworm.com/rss/comments.php?id=2978011</comments>
            <pubDate>Tue, 03 Nov 2009 00:00:00 +0100</pubDate>
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        <item>
            <title>Inositide signalling in the nucleus: from physiology to pathology.</title>
            <link>http://www.medworm.com/index.php?rid=2978010&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895834%26dopt%3DAbstract</link>
            <description>Authors: Cocco L, Follo MY, Faenza I, Billi AM, Ramazzotti G, Martelli AM, Manzoli L, Weber G
    
    PMID: 19895834 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
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        <comments>http://www.medworm.com/rss/comments.php?id=2978010</comments>
            <pubDate>Tue, 03 Nov 2009 00:00:00 +0100</pubDate>
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            <title>Mitotic recombination in haematological malignancy.</title>
            <link>http://www.medworm.com/index.php?rid=2978009&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895835%26dopt%3DAbstract</link>
            <description>Authors: Raghavan M, Gupta M, Molloy G, Chaplin T, Young BD
    
    PMID: 19895835 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
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            <pubDate>Tue, 03 Nov 2009 00:00:00 +0100</pubDate>
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            <title>Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration.</title>
            <link>http://www.medworm.com/index.php?rid=2978008&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19895836%26dopt%3DAbstract</link>
            <description>Authors: Chiche J, Ilc K, Brahimi-Horn MC, Pouyss&amp;#xE9;gur J
    
    PMID: 19895836 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Tue, 03 Nov 2009 00:00:00 +0100</pubDate>
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            <title>Can BAD pores be good? New insights from examining BAD as a target of RAF kinases.</title>
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            <description>Authors: Polzien L, Benz R, Rapp UR
    
    PMID: 19895838 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Tue, 03 Nov 2009 00:00:00 +0100</pubDate>
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            <title>Assay of dense-core vesicle exocytosis using permeabilized PC12 cells.</title>
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            <description>Authors: Gao J, Takeuchi H, Umebayashi H, Zhang Z, Matsuda M, Hirata M
    
    PMID: 19895839 [PubMed - as supplied by publisher] (Source: Advances in Enzyme Regulation)</description>
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            <pubDate>Tue, 03 Nov 2009 00:00:00 +0100</pubDate>
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            <link>http://www.medworm.com/index.php?rid=394247&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16854450%26dopt%3DAbstract</link>
            <description>Authors: Goto K, Nakano T, Hozumi Y
    
    PMID: 16854450 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394247</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394247</guid>        </item>
        <item>
            <title>Pike tyrosine phosphorylation regulates its apoptotic cleavage during programmed cell death.</title>
            <link>http://www.medworm.com/index.php?rid=394245&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16854451%26dopt%3DAbstract</link>
            <description>Authors: Tang X, Ye K
    
    PMID: 16854451 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394245</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394245</guid>        </item>
        <item>
            <title>Phosphatidylinositol transfer proteins: from closed for transport to open for exchange.</title>
            <link>http://www.medworm.com/index.php?rid=394243&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16854452%26dopt%3DAbstract</link>
            <description>Authors: Wirtz KW, Schouten A, Gros P
    
    PMID: 16854452 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394243</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394243</guid>        </item>
        <item>
            <title>Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.</title>
            <link>http://www.medworm.com/index.php?rid=394241&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16854453%26dopt%3DAbstract</link>
            <description>Authors: McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M
    The Ras/Raf/MEK/ERK and PI3K/PTEN/AKT signaling cascades play critical roles in the transmission of signals from growth factor receptors to regulate gene expression and prevent apoptosis. Components of these pathways are mutated or aberrantly expressed in human cancer (e.g., Ras, B-Raf, PI3K, PTEN, Akt). Also, mutations occur at genes encoding upstream receptors (e.g., EGFR and Flt-3) and chimeric chromosomal translocations (e.g., BCR-ABL) which transmit their signals through these cascades. These pathways interact with each other to regulate growth and in some cases tumorigenesis. For example, in some cells, PTEN...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394241</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394241</guid>        </item>
        <item>
            <title>Analysis of two diacylglycerol kinase activities in mixed micelles.</title>
            <link>http://www.medworm.com/index.php?rid=394239&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16854454%26dopt%3DAbstract</link>
            <description>Authors: Tu-Sekine B, Ostroski M, Raben DM
    
    PMID: 16854454 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394239</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394239</guid>        </item>
        <item>
            <title>Protein phosphatase regulation by PRIP, a PLC-related catalytically inactive protein--implications in the phospho-modulation of the GABAA receptor.</title>
            <link>http://www.medworm.com/index.php?rid=394237&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16854455%26dopt%3DAbstract</link>
            <description>Authors: Yanagihori S, Terunuma M, Koyano K, Kanematsu T, Ho Ryu S, Hirata M
    PRIP, phospholipase C related, but catalytically inactive protein was first identified as a novel inositol 1,4,5-trisphosphate binding protein. It has a number of binding partners including protein phosphatase (PP1 and 2A), GABAA receptor associated protein, and the beta subunits of GABAA receptors, in addition to inositol 1,4,5-trisphosphate. The identification of these molecules led us to examine the possible involvement of PRIP in the phospho-regulation of the beta subunits of GABAA receptors using hippocampal neurons prepared from PRIP-1 and 2 double knock-out (DKO) mice. Experiments were performed with special reference to the dephosphorylation processes of the beta subunits. The phosphorylation of beta3 ...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394237</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394237</guid>        </item>
        <item>
            <title>Caveolin-1 inhibits anoikis and promotes survival signaling in cancer cells.</title>
            <link>http://www.medworm.com/index.php?rid=394235&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16857240%26dopt%3DAbstract</link>
            <description>Authors: Ravid D, Maor S, Werner H, Liscovitch M
    
    PMID: 16857240 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394235</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394235</guid>        </item>
        <item>
            <title>The regulation and function of inositol 1,4,5-trisphosphate 3-kinases.</title>
            <link>http://www.medworm.com/index.php?rid=394233&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16857241%26dopt%3DAbstract</link>
            <description>Authors: Irvine RF, Lloyd-Burton SM, Yu JC, Letcher AJ, Schell MJ
    
    PMID: 16857241 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394233</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394233</guid>        </item>
        <item>
            <title>Modulation of cancer pathways by inhibitors of guanylate metabolism.</title>
            <link>http://www.medworm.com/index.php?rid=394231&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16857242%26dopt%3DAbstract</link>
            <description>Authors: Oláh E, Kökény S, Papp J, Bozsik A, Keszei M
    
    PMID: 16857242 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394231</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394231</guid>        </item>
        <item>
            <title>Characterization of the hemopoietic defect in early stages of the myelodysplastic syndromes.</title>
            <link>http://www.medworm.com/index.php?rid=394229&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16857243%26dopt%3DAbstract</link>
            <description>Authors: Vyas P, Sternberg A
    Myelodysplasia (MDS) is a heterogeneous disorder characterised by bone marrow failure and progression to acute myeloid leukaemia where the molecular and cellular haematopoietic defects are poorly understood. To gain insight into this the pathogenesis of this condition, we analyzed gene expression profiles of bone marrow CD34+ stem/progenitor cells from patients with MDS at a early stage in the disease and compared them with profiles from CD34+ cells from age-matched controls and patients with non-MDS anaemia. Given the heterogeneity of early MDS, a surprisingly consistent finding was decreased expression of B-cell lineage affiliated genes in MDS patients compared to normal controls and samples with non-MDS anaemia. These findings were then confirmed in the ...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394229</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394229</guid>        </item>
        <item>
            <title>Laminopathies: a chromatin affair.</title>
            <link>http://www.medworm.com/index.php?rid=394227&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16857244%26dopt%3DAbstract</link>
            <description>Authors: Maraldi NM, Lattanzi G, Capanni C, Columbaro M, Mattioli E, Sabatelli P, Squarzoni S, Manzoli FA
    
    PMID: 16857244 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394227</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394227</guid>        </item>
        <item>
            <title>Activation of phosphoinositide 3-kinase C2 beta in the nuclear matrix during compensatory liver growth.</title>
            <link>http://www.medworm.com/index.php?rid=394225&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16857245%26dopt%3DAbstract</link>
            <description>Authors: Sindić A, Crljen V, Matković K, Lukinović-Skudar V, Visnjić D, Banfić H
    In the nuclear matrix harvested 20 h after partial hepatectomy, an increase in immunoprecipitable PI3K-C2beta activity is observed, which is sensitive to wortmannin (10 Mm) and shows strong preference for PtdIns over PtdIns(4)P as a substrate. On western blots PI3K-C2beta revealed a single immunoreactive band of 180 kD, whereas 20 h after partial hepatectomy gel shift of 18kDa was noticed in the nuclear matrix, suggesting that observed activation of enzyme is achieved by proteolysis. As it is know that PI3K-C2alpha is associated with nuclear speckles [Didichenko SA, Thelen M. Phosphatidylinositol 3-kinase C2alpha contains a nuclear localization sequence and associates with nuclear speckles. J Biol Che...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394225</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394225</guid>        </item>
        <item>
            <title>Localization and regulation of muscle fructose-1,6-bisphosphatase, the key enzyme of glyconeogenesis.</title>
            <link>http://www.medworm.com/index.php?rid=394223&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16857246%26dopt%3DAbstract</link>
            <description>Authors: Dzugaj A
    
    PMID: 16857246 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394223</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394223</guid>        </item>
        <item>
            <title>Regulation of DNA methyltransferase 1.</title>
            <link>http://www.medworm.com/index.php?rid=394221&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16859735%26dopt%3DAbstract</link>
            <description>Authors: Spada F, Rothbauer U, Zolghadr K, Schermelleh L, Leonhardt H
    
    PMID: 16859735 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394221</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394221</guid>        </item>
        <item>
            <title>Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes.</title>
            <link>http://www.medworm.com/index.php?rid=394218&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16860376%26dopt%3DAbstract</link>
            <description>Authors: Wu C, Khan SA, Peng LJ, Lange AJ
    Fructose-2,6-bisphosphate (F26P2) was identified as a regulator of glucose metabolism over 25 years ago. A truly bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PFK2/FBP2), with two active sites synthesizes F26P2 from fructose-6-phosphate (F6P) and ATP or degrades F26P2 to F6P and Pi. In the classic view, F26P2 regulates glucose metabolism by allosteric effects on 6-phosphofructo-1-kinase (6PFK1, activation) and fructose-1,6-bisphosphatase (FBPase, inhibition). When levels of F26P2 are high, glycolysis is enhanced and gluconeogenesis is inhibited. In this regard, altering levels of F26P2 via 6PFK2/FBP2 overexpression has been used for metabolic modulation, and has been shown capable of restoring euglycemia in rodent ...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394218</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394218</guid>        </item>
        <item>
            <title>SHIP1/2 interaction with tyrosine phosphorylated peptides mimicking an immunoreceptor signalling motif.</title>
            <link>http://www.medworm.com/index.php?rid=394216&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16876851%26dopt%3DAbstract</link>
            <description>Authors: Pesesse X, Backers K, Moreau C, Zhang J, Blero D, Paternotte N, Erneux C
    
    PMID: 16876851 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394216</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394216</guid>        </item>
        <item>
            <title>Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species.</title>
            <link>http://www.medworm.com/index.php?rid=394214&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16887173%26dopt%3DAbstract</link>
            <description>Authors: Kobayashi M, Yamamoto M
    
    PMID: 16887173 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394214</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394214</guid>        </item>
        <item>
            <title>A role for mitotic recombination in leukemogenesis.</title>
            <link>http://www.medworm.com/index.php?rid=394212&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16890980%26dopt%3DAbstract</link>
            <description>Authors: Young BD, Debernardi S, Lillington DM, Skoulakis S, Chaplin T, Foot NJ, Raghavan M
    
    PMID: 16890980 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394212</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394212</guid>        </item>
        <item>
            <title>Proceedings of the 46th International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues, Bologna, Italy, October 3-4, 2005.</title>
            <link>http://www.medworm.com/index.php?rid=394210&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16919314%26dopt%3DAbstract</link>
            <description>Authors: 
    
    PMID: 16919314 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394210</comments>
            <pubDate>Sun, 01 Jan 2006 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394210</guid>        </item>
        <item>
            <title>Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases.</title>
            <link>http://www.medworm.com/index.php?rid=394296&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16005050%26dopt%3DAbstract</link>
            <description>Authors: Naschberger E, Bauer M, Stürzl M
    Blood vessel activation in inflammatory diseases is triggered by a myriad of different factors that partially reveal opposite activities on endothelial cells (EC). For example, inflammatory cytokines (IC) inhibit EC proliferation and induce cell adhesiveness for leukocytes. In contrast, angiogenic growth factors (AGF) activate EC proliferation and inhibit cell adhesiveness for leukocytes. In consequence, IC and AGF may induce two different activation phenotypes in EC that appear in a temporally and/or spatially coordinated manner in inflammatory tissues. Human guanylate binding protein-1 (hGBP-1) is a member of the large GTPase protein family. New results demonstrate that hGBP-1 is a specific marker of IC-activated EC that allows to differenti...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394296</comments>
            <pubDate>Sat, 01 Jan 2005 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394296</guid>        </item>
        <item>
            <title>Functional analysis and secondary expression profiling of candidate genes deregulated in conjunction with oncogenic Ras signaling.</title>
            <link>http://www.medworm.com/index.php?rid=394292&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16023704%26dopt%3DAbstract</link>
            <description>Authors: Raudies O, Kuban RJ, Hamacher F, Klein-Hitpass L, Tchernitsa OI, Sers C, Herzel HP, Schäfer R
    
    PMID: 16023704 [PubMed - indexed for MEDLINE] (Source: Advances in Enzyme Regulation)</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394292</comments>
            <pubDate>Sat, 01 Jan 2005 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394292</guid>        </item>
        <item>
            <title>Emerging roles of phosphatidylinositol monophosphates in cellular signaling and trafficking.</title>
            <link>http://www.medworm.com/index.php?rid=394288&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16023705%26dopt%3DAbstract</link>
            <description>Authors: Pendaries C, Tronchère H, Racaud-Sultan C, Gaits-Iacovoni F, Coronas S, Manenti S, Gratacap MP, Plantavid M, Payrastre B
    The phosphoinositide metabolism that is highly controlled by a set of kinases, phosphatases and phospholipases leads to the production of several second messengers playing critical roles in intracellular signal transduction mechanisms. Recent discoveries have unraveled unexpected roles for the three phosphatidylinositol monophosphates, PtdIns(3)P, PtdIns(4)P and PtdIns(5)P, that appear now as important lipid messengers able to specifically interact with proteins. The formation of functionally distinct and independently regulated pools of phosphatidylinositol monophosphates probably contributes to the specificity of the interactions with their targets. The r...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394288</comments>
            <pubDate>Sat, 01 Jan 2005 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394288</guid>        </item>
        <item>
            <title>Nuclear phospholipase C beta1, regulation of the cell cycle and progression of acute myeloid leukemia.</title>
            <link>http://www.medworm.com/index.php?rid=394284&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16024064%26dopt%3DAbstract</link>
            <description>Authors: Cocco L, Manzoli L, Palka G, Martelli AM
    A large number of observations have hinted at the fact that location impinges on function of some of the main players of nuclear inositol lipid cycle. PLC beta1 is a well-known example, given that it has been shown that only the enzyme located in the nucleus targets the cyclin D3/cdk4 complex, playing, in turn, a key role in the control of normal progression through the G1 phase of the cell cycle. The PLC beta1 gene, which is constituted of 36 small exons and large introns, maps on the short arm of human chromosome 20 (20pl2, nearby markers D20S917 and D20S177) with the specific probe (PAC clone HS881E24) spanning from exon 19 to 32 of the gene itself. The chromosome band 20pl2 has been shown to be rearranged in human diseases such as s...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394284</comments>
            <pubDate>Sat, 01 Jan 2005 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394284</guid>        </item>
        <item>
            <title>Down-regulation of increased signal transduction capacity in human cancer cells.</title>
            <link>http://www.medworm.com/index.php?rid=394282&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16054198%26dopt%3DAbstract</link>
            <description>Authors: Weber G
    Signal transduction capacity in human cancer cells is constitutively up-regulated by the markedly increased steady-state activities of the three synthetic enzymes, PI kinase, PIP kinase and PLC, which catalyze the conversion of PI to the second messengers IP3 and DAG. This evidence is supported by the elevated concentration of IP3 in human colon, ovarian and breast carcinoma samples and rat hepatocellular carcinomas and sarcoma. The decrease in activities of the two specific phosphatases in the degradative pathway of signal transduction provides an amplified capacity for IP3 production. The elevated second messenger concentrations should lead to increased calcium release and protein kinase C activation. These biochemical alterations should confer selective biological a...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394282</comments>
            <pubDate>Sat, 01 Jan 2005 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394282</guid>        </item>
        <item>
            <title>Peptide inhibitors of mammalian ribonucleotide reductase.</title>
            <link>http://www.medworm.com/index.php?rid=394280&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16054677%26dopt%3DAbstract</link>
            <description>Authors: Cooperman BS, Gao Y, Tan C, Kashlan OB, Kaur J
    Mammalian ribonucleotide reductase (mRR) is a chemotherapeutic target. In common with other class Ia RRs, the enzyme is composed of two subunits (mR1 and mR2), with mR1 containing both the active site and allosteric effector sites and mR2 containing a stable tyrosyl radical that is essential for enzymatic activity. mRR is inhibited by Ac-FTLDADF (denoted P7), corresponding to the C-terminus of mR2, which competes with mR2 for binding to mR1. The enzyme has two physiologically important active forms, mR12mR22 and mR16(mR22)j (j=1-3), with high ATP concentrations favoring the latter. Here, we report on our progress in using structural and functional studies in conjunction with library screening to identify derivatives of tri-, tetra...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394280</comments>
            <pubDate>Sat, 01 Jan 2005 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394280</guid>        </item>
        <item>
            <title>Ras initiates phosphatidyl-inositol-3-kinase (PI3K)/PKB mediated signalling pathways in untransformed human peripheral blood T lymphocytes.</title>
            <link>http://www.medworm.com/index.php?rid=394278&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16083947%26dopt%3DAbstract</link>
            <description>Authors: Samstag Y, Nebl G
    Activation of T lymphocytes through costimulation of the T cell receptor/CD3 complex (TCR/CD3) and coreceptors (e.g. CD2 or CD28) leads to production of the growth factor interleukin-2 (IL-2) and subsequent proliferation. For these activation processes, remodelling of the actin cytoskeleton plays an important functional role. We have shown that the activity of the actin-remodelling protein cofilin is crucially involved in T lymphocyte activation processes. In unstimulated human peripheral blood T lymphocytes (PB-T) cofilin exists in its inactive ser-3-phosphorylated form. T lymphocyte activation through costimulation of TCR plus the coreceptors CD28 or CD2, respectively, induces the dephosphorylation of cofilin. Concomitantly, cofilin associates with the acti...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394278</comments>
            <pubDate>Sat, 01 Jan 2005 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394278</guid>        </item>
        <item>
            <title>Regulation of gene and protein expression in cardiac myocyte hypertrophy and apoptosis.</title>
            <link>http://www.medworm.com/index.php?rid=394276&amp;cid=s_34422_70_f&amp;fid=34422&amp;url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D16084574%26dopt%3DAbstract</link>
            <description>Authors: Clerk A, Cullingford TE, Kemp TJ, Kennedy RA, Sugden PH
    Considerable efforts have been expended in elucidating the inter-cellular and intra-cellular signaling pathways which elicit cardiac myocyte hypertrophy or apoptosis, and in identifying the changes which are associated with the end-stage of the response. The challenge now is to link the two. Although some of the signaling effects will be the acute modulation of existing protein function, long-term effects which bring about and maintain the hypertrophic state or which culminate in cell death are mediated at the level of gene and protein expression. With the advances in micro-array technology and genome sequencing, it is now possible to obtain a picture of the global gene expression profile in myocytes or in whole heart whi...</description>
            <author>Advances in Enzyme Regulation</author>
            <type>journals</type>
        <comments>http://www.medworm.com/rss/comments.php?id=394276</comments>
            <pubDate>Sat, 01 Jan 2005 07:00:00 +0100</pubDate>
            <guid isPermaLink="false">394276</guid>        </item>
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