MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Allergy' source. Wed, 08 Feb 2012 06:42:44 +0100 http://www.medworm.com/index.php?rid=5666430&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2012.02789.x ConclusionsBoth VA and cetirizine significantly reduced type I hypersensitivity itch in patients with AD, compared with both placebo and NI. Timing of acupuncture application was important, as VAa had the most significant effect on itch, potentially because of counter‐irritation and/or distraction. Itch reduction following cetirizine coincided with reduced attention. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5666430 Wed, 08 Feb 2012 05:00:00 +0100 5666430 http://www.medworm.com/index.php?rid=5666429&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2012.02790.x ConclusionDirect membrane transfer from perivasal mast cells into nearby blood vessels constitutes a novel mechanism to modulate endothelial surface features with apparent significance in allergic diseases. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5666429 Wed, 08 Feb 2012 05:00:00 +0100 5666429 http://www.medworm.com/index.php?rid=5666433&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2012.02791.x ConclusionsPrenatal stress was independently associated with elevated cord blood IgE. Mechanisms underlying stress effects on fetal immunomodulation may differ based on maternal atopic status. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5666433 Mon, 06 Feb 2012 05:00:00 +0100 5666433 http://www.medworm.com/index.php?rid=5666432&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2012.02788.x ConclusionThis feasibility study shows thermography can detect inflammation caused by nasal challenges whilst employing one thousand‐fold less peanut than an oral challenge. This novel technique could be developed to provide a rapid, safe and objective clinical allergy test. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5666432 Mon, 06 Feb 2012 05:00:00 +0100 5666432 http://www.medworm.com/index.php?rid=5666431&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2012.02785.x This study presents outcomes and conclusions from these discussions. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5666431 Mon, 06 Feb 2012 05:00:00 +0100 5666431 http://www.medworm.com/index.php?rid=5666428&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2012.02787.x AbstractEarly in the 1990s, several case series described adults suffering from dysphagia and children with refractory reflux symptoms, both accompanied by an eosinophil‐predominant infiltration, thereby conclusively distinguishing it from gastroesophageal reflux disease. Eosinophilic esophagitis (EoE) was recognized as its own entity in the adult and in the pediatric literature. In the last decade, evidence has accumulated that EoE represents a T‐helper (Th)2‐type inflammatory disease. Remodeling of the esophagus is a hallmark of EoE, leading to esophageal dysfunction and bolus impaction. Familial occurrence and disease association with single‐nucleotide polymorphisms underscore the influence of genetics in this disease. Eosinophilic esophagitis may affect individuals at any age, ... Allergy journals http://www.medworm.com/rss/comments.php?id=5666428 Wed, 01 Feb 2012 05:00:00 +0100 5666428 http://www.medworm.com/index.php?rid=5607643&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02783.x AbstractThe dramatic increase in the incidence and severity of allergy and asthma has been proposed to be linked with an altered exposure to, and colonization by, micro‐organisms, particularly early in life. However, other lifestyle factors such as diet and physical activity are also thought to be important, and it is likely that multiple environmental factors with currently unrecognized interactions contribute to the atopic state. This review will focus on the potential role of microbial metabolites in immunoregulatory functions and highlights the known molecular mechanisms, which may mediate the interactions between diet, microbiota, and protection from allergy and asthma. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5607643 Fri, 20 Jan 2012 11:16:35 +0100 5607643 http://www.medworm.com/index.php?rid=5607645&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02782.x Conclusion:These results show the critical role of NALT for the induction of allergic responses in the upper airway at least in part by means of class switching to IgE in situ. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5607645 Thu, 19 Jan 2012 05:00:00 +0100 5607645 http://www.medworm.com/index.php?rid=5607644&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02784.x AbstractWork‐related asthma (WRA) is a relevant problem in several countries, is cause of disability and socioeconomic consequences for both the patient and the society and is probably still underdiagnosed. A correct diagnosis is extremely important to reduce or limit the consequences of the disease. This consensus document was prepared by a EAACI Task Force consisting of an expert panel of allergologists, pneumologists and occupational physicians from different European countries. This document is not intended to address in detail the full diagnostic work‐up of WRA, nor to be a formal evidence‐based guideline. It is written to provide an operative protocol to allergologists and physicians dealing with asthma useful for identifying the subjects suspected of having WRA to address them... Allergy journals http://www.medworm.com/rss/comments.php?id=5607644 Thu, 19 Jan 2012 05:00:00 +0100 5607644 http://www.medworm.com/index.php?rid=5596662&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02765.x Conclusion:The predominance of the CLA+ response to peanut in peanut allergic patients is consistent with the hypothesis that allergic sensitization occurs through the skin. The predominant α4β7+ response in peanut‐tolerant groups suggests that allergen exposure through the GI tract induces tolerance. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5596662 Tue, 17 Jan 2012 11:15:38 +0100 5596662 http://www.medworm.com/index.php?rid=5580505&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02778.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5580505 Fri, 13 Jan 2012 11:15:31 +0100 5580505 http://www.medworm.com/index.php?rid=5580504&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02770.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5580504 Fri, 13 Jan 2012 11:15:29 +0100 5580504 http://www.medworm.com/index.php?rid=5580495&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02777.x Conclusion:These results suggest that intranasal immunization with Ag‐encased OML may be an effective immunotherapy for food allergies, as it induces a subset of regulatory CD8+T cells as well as CD4+ CD25+ Foxp3+T cell and modulates humoral immune responses in allergen‐sensitized mice. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5580495 Fri, 13 Jan 2012 11:14:55 +0100 5580495 http://www.medworm.com/index.php?rid=5580503&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02781.x Conclusions:The major allergens of P. dominulus’ and Vespula vulgaris’ venom, namely phoshpholipases and antigen 5s, are required to discriminate the probable sensitizing species in vespid‐allergic patients. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5580503 Mon, 09 Jan 2012 05:00:00 +0100 5580503 http://www.medworm.com/index.php?rid=5580502&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02780.x Conclusions: This first publication about prevalence of fractures and osteoporosis in patients with ISM shows that the risk of osteoporotic fractures is high, especially in men. Higher urinary MH levels are associated with a higher risk of osteoporotic manifestations. Routine measurements of BMD and vertebral morphometry are warranted in these patients for early detection of osteoporosis. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5580502 Mon, 09 Jan 2012 05:00:00 +0100 5580502 http://www.medworm.com/index.php?rid=5580501&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02779.x Conclusion:Exposure at work appears to be a risk factor for the occurrence of CRS and for its recurrence or persistence, as evidenced by the need for revision surgery. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5580501 Mon, 09 Jan 2012 05:00:00 +0100 5580501 http://www.medworm.com/index.php?rid=5580500&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02776.x Conclusion:Our findings provide evidence that miR‐23b is capable of inducing tolerogenic DC activity and Treg responses in vitro through the inhibition of the Notch1 and NF‐κB signalling pathways; thus, miR‐23b might represent a therapeutic target for the management of allergic diseases. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5580500 Mon, 09 Jan 2012 05:00:00 +0100 5580500 http://www.medworm.com/index.php?rid=5580499&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02775.x Conclusions:In our model, maternal allergen exposures during pregnancy prevented later allergen‐mediated sensitization and airway inflammation by allergen‐specific tolerance induction in the offspring. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5580499 Mon, 09 Jan 2012 05:00:00 +0100 5580499 http://www.medworm.com/index.php?rid=5580498&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02773.x Conclusion:In asthma, ECM in ASM is related to the dynamics of airway function in the absence of differences in ECM expression between asthma and controls. This indicates that the ASM layer in its full composition is a major structural component in determining variable airways obstruction in asthma. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5580498 Mon, 09 Jan 2012 05:00:00 +0100 5580498 http://www.medworm.com/index.php?rid=5580497&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02771.x Conclusions:Dietary supplementation with GF/Bb enhances serum galectin‐9 levels, which associates with the prevention of allergic symptoms. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5580497 Mon, 09 Jan 2012 05:00:00 +0100 5580497 http://www.medworm.com/index.php?rid=5580496&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02768.x Conclusion:Our results indicate that both angiopoietins levels are higher in SRA compared with moderate asthma and healthy subjects. In SRA, Ang‐2 is associated with mediators involved in both the inflammatory and the vascular remodeling processes. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5580496 Mon, 09 Jan 2012 05:00:00 +0100 5580496 http://www.medworm.com/index.php?rid=5537232&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02767.x Conclusions:These results indicate that both genetic and environmental factors presumably influence the development of foetal Tregs. Low cord blood Treg numbers may predict early atopic dermatitis. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5537232 Sat, 24 Dec 2011 23:48:37 +0100 5537232 http://www.medworm.com/index.php?rid=5537233&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02769.x Conclusions:We show the existence of UPR in nasal epithelial cells that is linked to oxidative stress leading to IL‐8 and LTB4 secretions. These mechanisms may participate in chronic inflammation in nasal polyposis. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5537233 Thu, 22 Dec 2011 05:00:00 +0100 5537233 http://www.medworm.com/index.php?rid=5523702&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02764.x Conclusion:Human basophils neither internalize, process nor present Bet v 1. Because Bet v 1 is a highly relevant allergen, we conclude that basophils play no role as APC in IgE‐mediated allergy in humans. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5523702 Wed, 21 Dec 2011 23:48:26 +0100 5523702 http://www.medworm.com/index.php?rid=5523703&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02766.x ConclusionsThis study showed a good NPV of diagnostic tests for hazelnut allergy in children which further improved by rCor a 1 spiking. However, the PPVs are moderate and decreased by spiking. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5523703 Mon, 19 Dec 2011 05:00:00 +0100 5523703 http://www.medworm.com/index.php?rid=5514869&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02763.x Conclusions:FasL activity may play an active role in resolving eosinophilic inflammation through regulating T cells and pro‐eosinophilic cytokine release during the allergic airway response. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5514869 Sun, 18 Dec 2011 23:47:50 +0100 5514869 http://www.medworm.com/index.php?rid=5514870&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02762.x Conclusion:A high proportion of English professional soccer players medicated for asthma/EIB (a third with reliever therapy only) do not present reversible airway obstruction or airway hyperresponsiveness to indirect stimuli. This underlines the importance of objective PFT to support a symptoms‐based diagnosis of asthma/EIB in athletes. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5514870 Sat, 17 Dec 2011 05:00:00 +0100 5514870 http://www.medworm.com/index.php?rid=5514872&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02755.x To cite this article: Benson AA, Toh JA, Vernon N, Jariwala SP. The role of vitamin D in the immunopathogenesis of allergic skin diseases. Allergy 2011; DOI: 10.1111/j.1398‐9995.2011.02755.x.AbstractVitamin D plays key roles in innate and adaptive immunity through the stimulation of Toll‐like receptors, increasing pro‐inflammatory cytokine production, and possibly enhancing T helper type 2 responses. These mechanisms may explain the growing body of evidence connecting vitamin D to allergic diseases, including asthma, food allergies, and allergic rhinitis. The data relating vitamin D to allergic skin diseases are equivocal with studies linking both high and low vitamin D levels to an increased risk of developing atopic dermatitis. In this paper, we describe the role of vitamin D in th... Allergy journals http://www.medworm.com/rss/comments.php?id=5514872 Fri, 16 Dec 2011 05:00:00 +0100 5514872 http://www.medworm.com/index.php?rid=5514871&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02753.x We present a series of 49 patients with confirmed allergy to NMBAs, six of whom required a subsequent surgery with neuromuscular blockade. Negative skin tests allowed the selection of an alternative NMBA, which was well tolerated in all 6 cases. We found an excellent negative predictive value of skin tests in our series but larger studies are required to properly address this question. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5514871 Fri, 16 Dec 2011 05:00:00 +0100 5514871 http://www.medworm.com/index.php?rid=5494322&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02757.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5494322 Mon, 12 Dec 2011 23:48:41 +0100 5494322 http://www.medworm.com/index.php?rid=5494321&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02756.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5494321 Mon, 12 Dec 2011 23:48:10 +0100 5494321 http://www.medworm.com/index.php?rid=5494320&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02740.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5494320 Mon, 12 Dec 2011 23:48:09 +0100 5494320 http://www.medworm.com/index.php?rid=5494318&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02761.x To cite this article: Calderón MA, Simons FER, Malling H‐J, Lockey RF, Moingeon P, Demoly P. Sublingual allergen immunotherapy: mode of action and its relationship with the safety profile. Allergy 2011; DOI: 10.1111/j.1398‐9995.2011.02761.xAbstractAllergen immunotherapy reorients inappropriate immune responses in allergic patients. Sublingual allergen immunotherapy (SLIT) has been approved, notably in the European Union, as an effective alternative to subcutaneous allergen immunotherapy (SCIT) for allergic rhinitis patients. Compared with SCIT, SLIT has a better safety profile. This is possibly because oral antigen‐presenting cells (mostly Langerhans and myeloid dendritic cells) exhibit a tolerogenic phenotype, despite constant exposure to danger signals from food and microbes. This... Allergy journals http://www.medworm.com/rss/comments.php?id=5494318 Mon, 12 Dec 2011 23:47:30 +0100 5494318 http://www.medworm.com/index.php?rid=5494319&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02760.x Conclusion:  Demethylation of specific regulatory elements within the FCER1G locus contributes to FcεRI overexpression on monocytes from patients with AD. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5494319 Sat, 10 Dec 2011 05:00:00 +0100 5494319 http://www.medworm.com/index.php?rid=5475885&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02758.x Conclusion:  Both protocols were effective compared with placebo and showed similar decreases for combined symptoms/medication score and all secondary endpoints, with the exception of nasal symptoms that were lower in the pre‐coseasonal group. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5475885 Tue, 06 Dec 2011 05:00:00 +0100 5475885 http://www.medworm.com/index.php?rid=5475884&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02759.x Conclusions:  The use of a tertile approach to analyse efficacy in AIT in SAR clinical studies can give a more accurate assessment of potential clinical benefit. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5475884 Tue, 06 Dec 2011 05:00:00 +0100 5475884 http://www.medworm.com/index.php?rid=5475883&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02747.x Conclusion:  The gene expression profiles are consistent with our previous findings that corticosteroids may exert a more potent anti‐inflammatory effect but may impair the restoration of the skin barrier. Corticosteroids are still the main treatment for severe and acutely exacerbated AD; pimecrolimus may be preferable for long‐term treatment and stabilization. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5475883 Thu, 01 Dec 2011 05:00:00 +0100 5475883 http://www.medworm.com/index.php?rid=5456543&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02754.x Conclusion:  In this study, a negative CD‐sens to peanut excluded peanut allergy. Both tests, CD‐sens to peanut and immunoassay for IgE‐antibody to the peanut components, appear to be safe, time saving and cost‐effective complements to DBPCFC. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5456543 Wed, 30 Nov 2011 23:48:28 +0100 5456543 http://www.medworm.com/index.php?rid=5456544&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02751.x To cite this article: Cicardi M, Bork K, Caballero T, Craig T, Li HH, Longhurst H, Reshef A, Zuraw B on behalf of HAWK (Hereditary Angioedema International Working Group). Evidence‐based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: consensus report of an International Working Group. Allergy 2011; DOI: 10.1111/j.1398‐9995.2011.02751.x.AbstractAngioedema owing to hereditary deficiency of C1 inhibitor (HAE) is a rare, life‐threatening, disabling disease. In the last 2 years, the results of well‐designed and controlled trials with existing and new therapies for this condition have been published, and new treatments reached the market. Current guidelines for the treatment for HAE were released before the new trials and befor... Allergy journals http://www.medworm.com/rss/comments.php?id=5456544 Wed, 30 Nov 2011 05:00:00 +0100 5456544 http://www.medworm.com/index.php?rid=5440046&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02749.x Conclusion:  Our results support the notion that local GC synthesis represents a novel immunoregulatory mechanism to limit uncontrolled immune responses in the lung and indicate that defective local steroidogenesis may contribute to the pathogenesis of allergic airway inflammation. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5440046 Thu, 24 Nov 2011 23:48:36 +0100 5440046 http://www.medworm.com/index.php?rid=5440047&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02736.x Conclusions:  Depigmented polymerized grass pollen extract is immunogenic and clinically effective in rush preseasonal SCIT. This form of immunotherapy may be an attractive option for some patients. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5440047 Wed, 23 Nov 2011 05:00:00 +0100 5440047 http://www.medworm.com/index.php?rid=5440048&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02752.x Conclusions:  Trials have tended to be small and of poor methodological quality, making it difficult to offer any definitive recommendations. Interventions that achieve substantial reductions in HDM load may offer some benefit in reducing rhinitis symptoms. Isolated use of HDM impermeable bedding is unlikely to prove effective. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5440048 Tue, 22 Nov 2011 05:00:00 +0100 5440048 http://www.medworm.com/index.php?rid=5421201&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02750.x Conclusion:  This study shows that a single standard of eight purified allergens can be used to compare allergen measurements by immunoassay. This approach will improve the continuity of environmental exposure assessments and provide improved standardization of allergy diagnostics and vaccines used for immunotherapy. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5421201 Fri, 18 Nov 2011 23:48:29 +0100 5421201 http://www.medworm.com/index.php?rid=5421202&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02748.x Conclusions:  Weight gain during infancy is positively associated with physician‐diagnosed asthma in school‐aged children. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5421202 Fri, 18 Nov 2011 05:00:00 +0100 5421202 http://www.medworm.com/index.php?rid=5406397&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02745.x Conclusions:  Functional assays of inhibitory IgG4 and IgE‐blocking factor may be more useful surrogates of clinical response than IgG4. Whether these antibody effects may serve as predictive biomarkers of clinical efficacy in individual patients requires further investigation. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5406397 Wed, 16 Nov 2011 01:56:15 +0100 5406397 http://www.medworm.com/index.php?rid=5399779&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02737.x Conclusion:  Although transient, suboptimal neonatal T‐cell activation pathways that signal through the NF‐κB complex may affect the developmental transition of T‐cell phenotypes in the periphery shortly after birth and may increase the risk of food allergy. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5399779 Sat, 12 Nov 2011 23:48:47 +0100 5399779 http://www.medworm.com/index.php?rid=5399780&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02744.x Conclusion:  In patients with OAS to apple, tolerance can be safely induced with slowly, gradually increasing consumption of apple. However, the observation of a relapse after discounting of apple consumption and absence of immunologic changes suggest that induced tolerance is only transient. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5399780 Thu, 10 Nov 2011 05:00:00 +0100 5399780 http://www.medworm.com/index.php?rid=5399781&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02743.x Conclusions:  The observed hierarchy of cross‐reactivity may play an important role for the future management of allergic diseases. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5399781 Sat, 05 Nov 2011 04:00:00 +0100 5399781 http://www.medworm.com/index.php?rid=5399784&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02709.x Conclusion:  Geographical variation in the prevalence of self‐reported asthma was observed across Europe, but overall, self‐reported asthma was more common in young adults, women and smokers. In all age groups, men and women, and irrespective of smoking behaviour, asthma was also associated with CRS. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5399784 Fri, 04 Nov 2011 04:00:00 +0100 5399784 http://www.medworm.com/index.php?rid=5399783&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02728.x To cite this article: Bousquet J, Heinzerling L, Bachert C, Papadopoulos NG, Bousquet PJ, Burney PG, Canonica GW, Carlsen KH, Cox L, Haahtela T, Lodrup Carlsen KC, Price D, Samolinski B, Simons FER, Wickman M, Annesi‐Maesano I, Baena‐Cagnani CE, Bergmann KC, Bindslev‐Jensen C, Casale TB, Chiriac A, Cruz AA, Dubakiene R, Durham SR, Fokkens WJ, Gerth‐van‐Wijk R, Kalayci O, Kowalski ML, Mari A, Mullol J, Nazamova‐Baranova L, O’Hehir RE, Ohta K, Panzner P, Passalacqua G, Ring J, Rogala B, Romano A, Ryan D, Schmid‐Grendelmeier P, Todo‐Bom A, Valenta R, Woehrl S, Yusuf OM, Zuberbier T, Demoly P. Practical guide to skin prick tests in allergy to aeroallergens. Allergy 2011; DOI: 10.1111/j.1398‐9995.2011.02728.xAbstractThis pocket guide is the result of a consensus reached betw... Allergy journals http://www.medworm.com/rss/comments.php?id=5399783 Fri, 04 Nov 2011 04:00:00 +0100 5399783 http://www.medworm.com/index.php?rid=5399782&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02735.x Conclusions:  Anti‐IL‐33 antibody has a therapeutic potential for experimental AR. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5399782 Fri, 04 Nov 2011 04:00:00 +0100 5399782 http://www.medworm.com/index.php?rid=5399785&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02742.x Conclusion:  We concluded that oral tolerance for food antigens is induced in two ways: (i) by initial exposure to antigen, or inherent tolerance, and (ii) by transfer of Tregs, or acquired tolerance. Because food allergies occur when inherent tolerance is absent, understanding of acquired tolerance is important for the development of therapies for food allergy. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5399785 Thu, 03 Nov 2011 04:00:00 +0100 5399785 http://www.medworm.com/index.php?rid=5358535&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02741.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5358535 Sun, 30 Oct 2011 22:49:16 +0100 5358535 http://www.medworm.com/index.php?rid=5358534&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02746.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5358534 Sun, 30 Oct 2011 22:49:04 +0100 5358534 http://www.medworm.com/index.php?rid=5358533&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02738.x Conclusion:  In 15 patients with confirmed food allergy and after exclusion of other diseases, 12 (85.7%) showed various unspecific nonerosive or erosive mucosal lesions within the small bowel, resulting, however, partially in grave consequences such as anemia. Lymphoid hyperplasia was the most prominent finding in 7 patients (50%), albeit infectious disease had been excluded. Anemia improved within 1 year after adequate antiallergic treatment. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5358533 Sun, 30 Oct 2011 22:48:14 +0100 5358533 http://www.medworm.com/index.php?rid=5346525&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02739.x Conclusion:  Early intervention with mite‐impermeable mattress covers is successful in reducing exposure to Der f1; it only temporarily reduces the risk of asthma symptoms and does not reduce the risk of hay fever, eczema, and allergic sensitization. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5346525 Tue, 25 Oct 2011 23:26:07 +0100 5346525 http://www.medworm.com/index.php?rid=5323422&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02734.x Conclusion:  Fractional exhaled nitric oxide monitoring revealed changes in FeNO prior to moderate exacerbations. Whether this can be used to prevent loss of asthma control should be further explored. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5323422 Mon, 17 Oct 2011 22:48:40 +0100 5323422 http://www.medworm.com/index.php?rid=5313603&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02733.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5313603 Fri, 14 Oct 2011 22:48:43 +0100 5313603 http://www.medworm.com/index.php?rid=5296275&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02732.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5296275 Sat, 08 Oct 2011 22:48:14 +0100 5296275 http://www.medworm.com/index.php?rid=5296277&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02730.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5296277 Sat, 08 Oct 2011 04:00:00 +0100 5296277 http://www.medworm.com/index.php?rid=5296276&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02731.x Conclusions:  PEST‐domain‐enriched tyrosine phosphatase is an important positive regulator of anaphylaxis. Pharmacological inhibition of its activity together with glucocorticoid administration provide an effective rescue for PSA in mice. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5296276 Sat, 08 Oct 2011 04:00:00 +0100 5296276 http://www.medworm.com/index.php?rid=5272865&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02729.x Conclusions:  Asthma is associated with an increased risk of long‐term all‐cause work disability. The risk increases further with chronic comorbidities and is especially high in patients with asthma and depression. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5272865 Sat, 01 Oct 2011 04:00:00 +0100 5272865 http://www.medworm.com/index.php?rid=5272872&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02687.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5272872 Thu, 29 Sep 2011 04:00:00 +0100 5272872 http://www.medworm.com/index.php?rid=5272871&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02701.x Conclusion:  The association between the FCER2 T2206C variant and asthma‐related hospitalizations in steroid‐treated asthma appears robust and may also be associated with other indicators of lack of ICS efficacy such as asthma symptoms and a requirement for higher daily doses of ICS. Our results suggest that the FCER2 T2206C variant might be a useful pharmacogenetic predictor of steroid refractory patients. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5272871 Thu, 29 Sep 2011 04:00:00 +0100 5272871 http://www.medworm.com/index.php?rid=5272870&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02723.x Conclusions:  The present data show that alveolar mast cells in patients with mild atopic asthma, but not atopic patients with AR, have turned into a highly FcεRI‐ and IgE‐expressing phenotype. These data support the hypothesis that increased FcεRI expression on alveolar mast cells is a novel disease‐specific feature of allergic asthma that is important for understanding asthma phenotypes and designing new therapeutic strategies. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5272870 Thu, 29 Sep 2011 04:00:00 +0100 5272870 http://www.medworm.com/index.php?rid=5272869&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02727.x Conclusion:  DNA vaccination showed protective and therapeutic efficacy against a clinically relevant allergen Bla g 1. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5272869 Thu, 29 Sep 2011 04:00:00 +0100 5272869 http://www.medworm.com/index.php?rid=5272868&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02725.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5272868 Thu, 29 Sep 2011 04:00:00 +0100 5272868 http://www.medworm.com/index.php?rid=5272867&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02726.x Conclusions:  Adolescent–parent disagreement on the adolescent’s HRQL was mainly associated with adolescents’ rather than parents’ perceptions and characteristics. Illness comprehension of the adolescent may be an important target for intervention aimed at reducing adolescent–parent disagreement. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5272867 Thu, 29 Sep 2011 04:00:00 +0100 5272867 http://www.medworm.com/index.php?rid=5272866&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02722.x Conclusions:  A single bronchial allergen challenge with HDM is accompanied by increased levels of allergen‐specific IgE for HDM in serum and an enhanced Th2 response to HDM still detectable 5 weeks after challenge. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5272866 Thu, 29 Sep 2011 04:00:00 +0100 5272866 http://www.medworm.com/index.php?rid=5259770&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02724.x Conclusion:  In summary, we demonstrated that OIT with SP and MP comprising the immunodominant regions of Ovm was safe and significantly reduced subsequent frequency of allergy to Ovm, and validated potential use of Ovm T‐cell epitope as an immunoregulator. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5259770 Wed, 28 Sep 2011 22:49:07 +0100 5259770 http://www.medworm.com/index.php?rid=5259773&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02718.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5259773 Tue, 27 Sep 2011 04:00:00 +0100 5259773 http://www.medworm.com/index.php?rid=5259772&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02719.x Conclusion:  The objective SCORAD and SCORAD showed a fair responsiveness. The MCIDs are an important prerequisite for the interpretation of published eczema trials and for the planning/sample size estimation of future trials. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5259772 Tue, 27 Sep 2011 04:00:00 +0100 5259772 http://www.medworm.com/index.php?rid=5259771&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02721.x Conclusion:  Our results suggest that school boards in legislated environments have made greater efforts to support students at risk for anaphylaxis compared to nonlegislated environments. However, significant gaps exist in both environments, especially with respect to EpiPen5 administration, content, and distribution of anaphylaxis emergency forms, and awareness of school procedures by school personnel and parents. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5259771 Tue, 27 Sep 2011 04:00:00 +0100 5259771 http://www.medworm.com/index.php?rid=5249940&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02720.x Conclusion:  In patients with MDH, the drug‐reactive T cells are contained in an in vivo pre‐activated T cell fraction. Therefore, they may show a lower threshold for activation by drugs. The reason for this in vivo T cell pre‐activation needs further investigations. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5249940 Sun, 25 Sep 2011 06:51:32 +0100 5249940 http://www.medworm.com/index.php?rid=5249943&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02708.x Conclusions:  The association between exclusive BF and asthma is modified by the genetic variants of FADS genotypes in children. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5249943 Wed, 21 Sep 2011 04:00:00 +0100 5249943 http://www.medworm.com/index.php?rid=5249942&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02711.x This article reviews and discusses published data on the relationship between vitamin D and asthma and allergy, emphasizing the need for controlled, prospective studies on vitamin D supplementation to clarify whether it has a role in the prevention of and treatment for asthma and allergic conditions. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5249942 Wed, 21 Sep 2011 04:00:00 +0100 5249942 http://www.medworm.com/index.php?rid=5249941&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02717.x Conclusion:  These results suggested that sunitinib relieves systemic and oral antigen‐induced anaphylaxes by the prevention of mast cell activation and hyperplasia in intestinal tissue directly and indirectly through an immunosuppressive effect. Sunitinib and its related kinase inhibitors might be potential drugs for the treatment of food allergy and systemic anaphylaxis. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5249941 Wed, 21 Sep 2011 04:00:00 +0100 5249941 http://www.medworm.com/index.php?rid=5249948&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02712.x Conclusion:  These findings suggest that a mouldy home environment in early life is associated with an increased risk of asthma particularly in young children and allergic rhinitis symptoms in school‐age children. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5249948 Mon, 19 Sep 2011 04:00:00 +0100 5249948 http://www.medworm.com/index.php?rid=5249947&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02716.x Conclusion:  A review of the efficacy and pharmacokinetic data from recently published controlled studies in the treatment of HAE attacks suggests that efficacy of C1INH therapy is optimal when C1INH activity levels are restored to the normal range. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5249947 Mon, 19 Sep 2011 04:00:00 +0100 5249947 http://www.medworm.com/index.php?rid=5249946&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02713.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5249946 Mon, 19 Sep 2011 04:00:00 +0100 5249946 http://www.medworm.com/index.php?rid=5249945&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02714.x Conclusion:  Fetal levels between 50 and 75 nmol/l appeared optimal for minimizing sensitization. While folate taken as a supplement in higher doses during the third trimester was associated with eczema, there was no effect on other allergic outcomes including sensitization. Further studies are needed to determine the significance of this. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5249945 Mon, 19 Sep 2011 04:00:00 +0100 5249945 http://www.medworm.com/index.php?rid=5249944&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02715.x Conclusions:  A standardized challenge vehicle proven to sufficiently blind processed, powdered hazelnut and celeriac ingredients and that can be reproducibly manufactured has been developed. This pilot study shows that the vehicle is promising for the confirmation of food allergy and determination of MEDs in adults and children with body weight >28.8 kg (approximately 7–11 years old). (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5249944 Mon, 19 Sep 2011 04:00:00 +0100 5249944 http://www.medworm.com/index.php?rid=5224031&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02707.x Conclusions:  Increased expression of IRF4 in allergen‐challenged CD4+ cells from patients with intermittent allergic rhinitis leads to activation of a complex transcriptional program, including Th2 cytokines. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5224031 Sat, 17 Sep 2011 06:46:47 +0100 5224031 http://www.medworm.com/index.php?rid=5207259&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02710.x Conclusions:  Staphylococcal α‐toxin contributes to Th1 polarization by induction of CXCL10 in macrophages. Macrophages from patients with AD and psoriasis responded to α‐toxin in the induction of Th1‐related chemokine CXCL10 diversely, which could favour the recruitment of distinct leucocyte subsets into the skin. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5207259 Mon, 12 Sep 2011 16:32:57 +0100 5207259 http://www.medworm.com/index.php?rid=5207260&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02704.x Conclusions:  Our study shows that CU sera are able to degranulate MCs through an IgE‐ and IgG‐independent mechanism. The nature of histamine‐releasing factors involved is still unclear, but our finding opens new ways to the understanding of the pathogenesis of CU, particularly in patients not showing circulating autoantibodies to FcεRI or IgE. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5207260 Mon, 12 Sep 2011 04:00:00 +0100 5207260 http://www.medworm.com/index.php?rid=5207262&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02695.x Conclusions:  The CU‐Q2oL Brazilian portuguese version was easily filled out, well accepted by the patients, demonstrated an acceptable validity and reliability and might be used to evaluate treatment outcomes and in clinical research. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5207262 Thu, 08 Sep 2011 04:00:00 +0100 5207262 http://www.medworm.com/index.php?rid=5207261&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02700.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5207261 Thu, 08 Sep 2011 04:00:00 +0100 5207261 http://www.medworm.com/index.php?rid=5207263&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02706.x Conclusion:  Overproduction of IL‐32 may be involved in the pathogenesis of CRS, although the role of IL‐32 in the inflammation in CRSsNP and CRSwNP may be different. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5207263 Wed, 07 Sep 2011 04:00:00 +0100 5207263 http://www.medworm.com/index.php?rid=5182976&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02693.x Conclusion:  At the investigated dose of AZM over 3 months, no significant benefit was found over placebo. Possible reasons could be disease severity in the investigated group, under‐dosage of AZM and under‐powering of the study. Therefore, more research is urgently required. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5182976 Thu, 01 Sep 2011 23:00:00 +0100 5182976 http://www.medworm.com/index.php?rid=5182975&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02694.x Conclusion:  In skin diseases, eosinophil expresses a broad spectrum of cytokines. The different cytokine expression patterns suggest distinct functional roles of eosinophils in these diseases that might be related to host defense, immunomodulation, fibrosis, and/or tumor development. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5182975 Thu, 01 Sep 2011 23:00:00 +0100 5182975 http://www.medworm.com/index.php?rid=5182974&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02698.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5182974 Thu, 01 Sep 2011 23:00:00 +0100 5182974 http://www.medworm.com/index.php?rid=5182973&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02699.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5182973 Thu, 01 Sep 2011 23:00:00 +0100 5182973 http://www.medworm.com/index.php?rid=5182972&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02702.x Conclusions:  A single dose of 20 U/kg C1‐INH concentrate is safe and provides reliable efficacy in the long‐term treatment of successive HAE attacks at any body location. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5182972 Thu, 01 Sep 2011 23:00:00 +0100 5182972 http://www.medworm.com/index.php?rid=5182971&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02703.x To cite this article: Allakhverdi Z, Delespesse G. Hematopoietic progenitor cells are innate Th2 cytokine‐producing cells. Allergy 2011; DOI: 10.1111/j.1398‐9995.2011.02703.xAbstractTypically, hematopoietic stem/progenitor cells (HSPCs) reside within the bone marrow (BM) where they give rise to all hematopoietic populations. However, HSPCs also constantly egress from the BM into the blood and circulate through the peripheral tissues where upon encounter with inflammatory stimuli and epithelial cell‐derived cytokines they rapidly release very high levels of Th2 cytokines/chemokines and differentiate into Th2 effector cells. The novel concept of the dual function of HSPCs as hematopoietic precursors and potent Th2 cytokine producers has important clinical implications in various inflam... Allergy journals http://www.medworm.com/rss/comments.php?id=5182971 Thu, 01 Sep 2011 23:00:00 +0100 5182971 http://www.medworm.com/index.php?rid=5182970&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02705.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5182970 Wed, 31 Aug 2011 23:00:00 +0100 5182970 http://www.medworm.com/index.php?rid=5175234&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02697.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5175234 Tue, 30 Aug 2011 12:10:22 +0100 5175234 http://www.medworm.com/index.php?rid=5175235&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02696.x Conclusions:  Allergen reactivity of peripheral blood basophils is not a biomarker for adverse events or early onset of clinical responses to SLIT. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5175235 Sun, 28 Aug 2011 23:00:00 +0100 5175235 http://www.medworm.com/index.php?rid=5160563&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02688.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5160563 Sat, 27 Aug 2011 12:12:03 +0100 5160563 http://www.medworm.com/index.php?rid=5160564&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02682.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5160564 Wed, 24 Aug 2011 23:00:00 +0100 5160564 http://www.medworm.com/index.php?rid=5160565&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02685.x Conclusions:  Genetic combinations described have functional implications in the PTGDR promoter activity by changing the transcription factors affinity that will help characterize different risk groups. The differences observed in the transcription factors affinity and in the methylation pattern bring insight into different transcription regulation in these patients. To the best of our knowledge, this is the first work in which the implication of genetic and epigenetic factors of PTGDR has been characterized pointing to putative therapeutic targets. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5160565 Tue, 23 Aug 2011 23:00:00 +0100 5160565 http://www.medworm.com/index.php?rid=5160566&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02692.x Conclusions:  Sequences with low PD value (<8.5) to known IgE epitopes could contribute to cross‐reactivity between allergens. This further validates the PD scoring method for predicting cross‐reactive epitopes in allergens. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5160566 Mon, 22 Aug 2011 23:00:00 +0100 5160566 http://www.medworm.com/index.php?rid=5160567&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02686.x To cite this article: Maurer M, Bader M, Bas M, Bossi F, Cicardi M, Cugno M, Howarth P, Kaplan A, Kojda G, Leeb‐Lundberg F, Lötvall J, Magerl M. New topics in bradykinin research. Allergy 2011; DOI: 10.1111/j.1398‐9995.2011.02686.xAbstractBradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B1 and B2 receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The developme... Allergy journals http://www.medworm.com/rss/comments.php?id=5160567 Sun, 21 Aug 2011 23:00:00 +0100 5160567 http://www.medworm.com/index.php?rid=5142828&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02690.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5142828 Sat, 20 Aug 2011 12:10:29 +0100 5142828 http://www.medworm.com/index.php?rid=5142831&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02689.x Conclusions:  This study shows that T cells and antibodies may show cross‐reactivity between different species without being naturally exposed to sPLA2s. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5142831 Wed, 17 Aug 2011 23:00:00 +0100 5142831 http://www.medworm.com/index.php?rid=5142830&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02683.x Conclusion:  The current work identified a novel major allergen of horsefly, Tab y 1, with antiplatelet aggregation and antithrombotic activities, which implicates Tab y 1 in helping horseflies suck host blood, meanwhile causing allergy in their human hosts. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5142830 Wed, 17 Aug 2011 23:00:00 +0100 5142830 http://www.medworm.com/index.php?rid=5142829&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02691.x Conclusions: Anisakis hypersensitivity and allergy are mainly a matter of dietary habits. Areas where marinated anchovies are popular can be considered as ‘endemic’ for this type of food allergy, whereas immigration and, possibly, new or imported trendy food styles, such as eating raw fish carpaccios or sushi, are a major causative factor in big cities of inland zones. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5142829 Wed, 17 Aug 2011 23:00:00 +0100 5142829 http://www.medworm.com/index.php?rid=5119408&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02684.x Conclusion:  Selective COX‐2 inhibitors may be unsafe in subjects with urticaria and/or angioedema caused by hypersensitivity reactions to NSAIDs with cross‐intolerance if they are intolerant to paracetamol. A quarter of patients who were intolerant to this drug were also intolerant to etoricoxib. In subjects with hypersensitivity to NSAIDs and intolerance to paracetamol, selective COX‐2 inhibitors should be administered as a controlled, incremental dose provocation test to assess tolerance. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5119408 Fri, 12 Aug 2011 13:56:52 +0100 5119408 http://www.medworm.com/index.php?rid=5119409&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02678.x Conclusion:  This study provides novel evidence of a link between S. aureus biofilms and skewing of the T‐cell response toward the T‐helper2 pathway that is independent of superantigen activities. Further research is required to confirm the cause–effect relationship of this association. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5119409 Wed, 10 Aug 2011 23:00:00 +0100 5119409 http://www.medworm.com/index.php?rid=5096046&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02681.x Conclusions:  Our data demonstrate that VDD may increase the risk of FS among individuals with certain genotypes, providing evidence of gene–vitamin D interaction on FS. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5096046 Fri, 05 Aug 2011 15:22:58 +0100 5096046 http://www.medworm.com/index.php?rid=5096047&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02677.x Conclusion:  The impressive clinical differences of cADRs may not be uniquely explained by the expression of granulysin. Additional factors such as drug‐specific activation and recruitment of NKp46+ cells to the epidermis may play a role in determining the severity of cADRs. Therefore, unraveling the effects of drugs on NK‐cell activation and trafficking may help to better understand the cytotoxic mechanisms behind cADRs. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5096047 Thu, 04 Aug 2011 23:00:00 +0100 5096047 http://www.medworm.com/index.php?rid=5086745&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02654.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5086745 Tue, 02 Aug 2011 14:06:42 +0100 5086745 http://www.medworm.com/index.php?rid=5086742&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02655.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5086742 Tue, 02 Aug 2011 14:06:39 +0100 5086742 http://www.medworm.com/index.php?rid=5078298&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02680.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5078298 Sat, 30 Jul 2011 14:00:58 +0100 5078298 http://www.medworm.com/index.php?rid=5078299&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02679.x Conclusion:  Metal needles and/or lancets are the tools of choice for skin prick testing. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5078299 Thu, 28 Jul 2011 23:00:00 +0100 5078299 http://www.medworm.com/index.php?rid=5063018&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02675.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5063018 Tue, 26 Jul 2011 13:56:23 +0100 5063018 http://www.medworm.com/index.php?rid=5052056&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02676.x Conclusion:  Rhinitis is common in asthma and impairs asthma control. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5052056 Sat, 23 Jul 2011 13:56:07 +0100 5052056 http://www.medworm.com/index.php?rid=5029679&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02674.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5029679 Sat, 16 Jul 2011 13:56:29 +0100 5029679 http://www.medworm.com/index.php?rid=5029680&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02673.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5029680 Wed, 13 Jul 2011 23:00:00 +0100 5029680 http://www.medworm.com/index.php?rid=5009234&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02672.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=5009234 Sat, 09 Jul 2011 13:56:36 +0100 5009234 http://www.medworm.com/index.php?rid=4998214&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02665.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4998214 Tue, 05 Jul 2011 13:59:38 +0100 4998214 http://www.medworm.com/index.php?rid=4998211&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02670.x Conclusion:  The results, based on serum samples prospectively collected in a cohort study, provide some support for the hypothesis that individuals with allergic sensitization are at reduced risk of glioma and confirm results from previous case–control studies. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4998211 Tue, 05 Jul 2011 13:58:29 +0100 4998211 http://www.medworm.com/index.php?rid=4998213&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02664.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4998213 Sun, 03 Jul 2011 23:00:00 +0100 4998213 http://www.medworm.com/index.php?rid=4998212&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02671.x Conclusion:  The NPV of NSAIDs drug provocation test is high. This should reassure physicians who might hesitate to prescribe NSAIDs, especially in patients with negative allergic work‐ups. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4998212 Sun, 03 Jul 2011 23:00:00 +0100 4998212 http://www.medworm.com/index.php?rid=4985254&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02669.x Conclusion:  Despite recently introduced guidelines on the standardization of allergen preparations and study design, the Task Force identified a need for universally accepted standards for the measurement of allergen content in SIT preparations, dosing protocols, and selection of clinical endpoints to enable dose‐response effects to be compared across studies. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4985254 Thu, 30 Jun 2011 23:00:00 +0100 4985254 http://www.medworm.com/index.php?rid=4935735&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02666.x Conclusion:  Two patient profiles with probably different areas of immune recognition are identified as follows: the profile 1 patients were allergic to the frequently positively reacting cluster 1 only, for whom electrostatic fields (molecular charge) seem important; the profile 2 patients reacted to clusters 1 and 2 and/or 3, for whom steric fields (structure) are determinant and who probably presented a global recognition of the corticosteroid skeleton. A modified classification is thus proposed. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4935735 Sat, 18 Jun 2011 13:56:53 +0100 4935735 http://www.medworm.com/index.php?rid=4935737&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02667.x Conclusion:  Api m 10 is a genuine allergen of A. mellifera venom with IgE sensitizing potential in a significant fraction of allergic patients independent of CCD reactivity. Thus, Api m 10 could become a key element for component‐resolved diagnostic tests and improved immunotherapeutic approaches in hymenoptera venom allergy. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4935737 Thu, 09 Jun 2011 23:00:00 +0100 4935737 http://www.medworm.com/index.php?rid=4935736&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02668.x Conclusion:  Nonallergic asthma is characterized by autoreactivity as well as increased coagulation and angiogenesis markers, which are known to enhance vascular permeability. The presence of circulating vasoactive factors may be relevant to understand the disease pathophysiology and to detect novel therapeutic strategies in nonallergic asthma. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4935736 Thu, 09 Jun 2011 23:00:00 +0100 4935736 http://www.medworm.com/index.php?rid=4935739&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02662.x Conclusions:  The anthroposophic lifestyle comprises several factors of interest for allergy development and is here shown to be associated with reduced risk of IgE sensitization already in infancy. Identifying the factors responsible for this association would be of significant clinical importance. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4935739 Wed, 08 Jun 2011 23:00:00 +0100 4935739 http://www.medworm.com/index.php?rid=4935738&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02663.x Conclusion:  IgE levels to rPen a 1 provided additional value to the diagnosis of shrimp allergy. Some allergens in mite extract are recognized by patients who are allergic to shrimp, though their clinical relevance remains unknown. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4935738 Wed, 08 Jun 2011 23:00:00 +0100 4935738 http://www.medworm.com/index.php?rid=4903346&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02617.x To cite this article: Rabe KF, Calhoun WJ, Smith N, Jimenez P. Can anti‐IgE therapy prevent airway remodeling in allergic asthma? Allergy 2011; DOI: 10.1111/j.1398‐9995.2011.02617.xAbstractAirway remodeling is a central feature of asthma. It is exemplified by thickening of the lamina reticularis and structural changes to the epithelium, submucosa, smooth muscle, and vasculature of the airway wall. Airway remodeling may result from persistent airway inflammation. Immunoglobulin E (IgE) is an important mediator of allergic reactions and has a central role in airway inflammation and asthma‐related symptoms. Anti‐IgE therapies (such as omalizumab) have the potential to block an early step in the allergic cascade and therefore have the potential to reduce airway remodeling. The reductio... Allergy journals http://www.medworm.com/rss/comments.php?id=4903346 Tue, 07 Jun 2011 13:56:39 +0100 4903346 http://www.medworm.com/index.php?rid=4903349&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02655.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4903349 Mon, 06 Jun 2011 23:00:00 +0100 4903349 http://www.medworm.com/index.php?rid=4903348&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02660.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4903348 Mon, 06 Jun 2011 23:00:00 +0100 4903348 http://www.medworm.com/index.php?rid=4903347&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02661.x To cite this article: Ebo DG, Leysen J, Mayorga C, Rozieres A, Knol EF, Terreehorst I. The in vitro diagnosis of drug allergy: status and perspectives. Allergy 2011; DOI: 10.1111/j.1398‐9995.2011.02661.x.AbstractAdverse drug reactions (ADR) can result from immune‐mediated (drug allergy) and nonimmune‐mediated mechanisms. In both types of reaction, conclusive diagnosis and appropriate management remain major problems in daily clinical practice. This review summarizes the potentials and shortcomings of the currently available in vitro tests in the diagnosis of immediate (mostly IgE mediated) and nonimmediate (mostly T‐cell mediated) drug allergy, particularly quantification of specific IgE, flow‐assisted analysis of in vitro activated lymphocytes and basophils and the enzyme‐link... Allergy journals http://www.medworm.com/rss/comments.php?id=4903347 Mon, 06 Jun 2011 23:00:00 +0100 4903347 http://www.medworm.com/index.php?rid=4894391&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02657.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4894391 Sun, 05 Jun 2011 13:58:38 +0100 4894391 http://www.medworm.com/index.php?rid=4894392&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02659.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4894392 Wed, 01 Jun 2011 23:00:00 +0100 4894392 http://www.medworm.com/index.php?rid=4884290&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02654.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4884290 Wed, 01 Jun 2011 13:56:40 +0100 4884290 http://www.medworm.com/index.php?rid=4877294&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02658.x Conclusion:  The present study provides definitive evidence to link a novel genetic mutation to the development of hereditary angioedema in patients from a Brazilian family. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4877294 Mon, 30 May 2011 13:56:17 +0100 4877294 http://www.medworm.com/index.php?rid=4877295&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02656.x To cite this article: Aalberse RC, Crameri R. IgE‐binding epitopes: a reappraisal. Allergy 2011; DOI: 10.1111/j.1398‐9995.2011.02656.xAbstractHere, we discuss various questions related to IgE epitopes: What are the technical possibilities and pitfalls, what is currently known, how can we put this information into hypothetical frameworks and the unavoidable question: how useful is this information for patient care or allergenicity prediction? We discuss the information obtained by (i) 3D structures of allergen–antibody complexes; (ii) analysis of allergen analogues; (iii) mimics without obvious structural similarity; (iv) mAbs competing with IgE; (v) repertoire analysis of cloned IgEs, and other developments. Based on limited data, four suggestions are presented in the literature: (i)... Allergy journals http://www.medworm.com/rss/comments.php?id=4877295 Sun, 29 May 2011 23:00:00 +0100 4877295 http://www.medworm.com/index.php?rid=4863353&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02653.x Conclusion:  For the first time, allergen‐induced Treg cells that inhibited both the sensitization and the elicitation of the allergic reaction were evidenced in gavaged wild‐type mice. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4863353 Thu, 26 May 2011 13:54:32 +0100 4863353 http://www.medworm.com/index.php?rid=4853752&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02647.x Conclusion:  Leukotriene B4 and LTD4 display both redundant and cooperative effects on intracellular signaling, gene expression, and chemotaxis in human monocytes. These findings suggest that therapies targeting either leukotriene alone may be less effective than approaches directed at both. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4853752 Tue, 24 May 2011 13:57:46 +0100 4853752 http://www.medworm.com/index.php?rid=4853754&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02638.x Conclusions:  TPI ASM8 attenuated a broad range of inflammatory and physiological changes after AIC, suggesting that CCR3, IL‐3, and GM‐CSF also are important targets for the management of asthma. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4853754 Mon, 23 May 2011 23:00:00 +0100 4853754 http://www.medworm.com/index.php?rid=4853753&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02646.x Conclusion:  This is the first European international multicentre prevalence study of CRS. In this multicentre survey of adults in Europe, about one in ten participants had CRS with marked geographical variation. Smoking was associated with having CRS in all parts of Europe. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4853753 Mon, 23 May 2011 23:00:00 +0100 4853753 http://www.medworm.com/index.php?rid=4848337&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02648.x Conclusions:  Our findings suggest that childhood asthma is associated with subsequent development of HI in early adolescence, which could be partly explained by genetic influences. Early strategies to identify children at risk may reduce burden of the disease in adolescence. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4848337 Sat, 21 May 2011 13:55:30 +0100 4848337 http://www.medworm.com/index.php?rid=4848339&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02651.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4848339 Fri, 20 May 2011 23:00:00 +0100 4848339 http://www.medworm.com/index.php?rid=4848338&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02652.x To cite this article:  Martin SF, Esser PR, Weber FC, Jakob T, Freudenberg MA, Schmidt M, Goebeler M. Invited review for the journal allergy mechanisms of chemical‐induced innate immunity in allergic contact dermatitis. Allergy 2011; DOI: 10.1111/j.1398‐9995.2011.02652.x.AbstractAllergic contact dermatitis (ACD) is one of the most prevalent occupational skin diseases and causes severe and long‐lasting health problems in the case of chronification. It is initiated by an innate inflammatory immune response to skin contact with low molecular weight chemicals that results in the priming of chemical‐specific, skin‐homing CD8+ Tc1/Tc17 and CD4+ Th1/Th17 cells. Following this sensitization step, T lymphocytes infiltrate the inflamed skin upon challenge with the same chemical. The T ce... Allergy journals http://www.medworm.com/rss/comments.php?id=4848338 Fri, 20 May 2011 23:00:00 +0100 4848338 http://www.medworm.com/index.php?rid=4842328&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02635.x Conclusion:  Cow’s milk protein intolerant patients cannot be distinguished from persons without cow’s milk protein intolerance on the basis of IgG subclass or IgA reactivity to cow’s milk allergens. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4842328 Fri, 20 May 2011 13:54:58 +0100 4842328 http://www.medworm.com/index.php?rid=4842329&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02637.x Conclusion:  Our findings suggest that the bacteria colonizing nasal polyps of CRSwNP patients may impact on or be determined by the presence/absence of IL‐5. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4842329 Mon, 16 May 2011 23:00:00 +0100 4842329 http://www.medworm.com/index.php?rid=4821383&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02645.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4821383 Sat, 14 May 2011 13:55:37 +0100 4821383 http://www.medworm.com/index.php?rid=4821384&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02618.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4821384 Thu, 12 May 2011 23:00:00 +0100 4821384 http://www.medworm.com/index.php?rid=4805138&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2011.02636.x Conclusions:  The single allergen sensitization profiles obtained with 17 recombinant wheat flour allergens and two CCDs revealed no major allergen for German bakers. The highest frequencies were found for α‐amylase inhibitors and CCDs. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=4805138 Wed, 11 May 2011 13:55:24 +0100 4805138