MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Allergy' source. Sat, 20 Mar 2010 13:39:14 +0100 http://www.medworm.com/index.php?rid=3351351&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02359.x Conclusion: These data suggest that EVs (especially, the protein components) secreted by LPS inhalation are a key intercellular communicator in the development of airway immune dysfunction to inhaled LPS-containing allergens. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3351351 Thu, 11 Mar 2010 00:00:00 +0100 3351351 http://www.medworm.com/index.php?rid=3351354&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02341.x Conclusion: We demonstrate that miltefosine is locally active in patients with AD and led to a sustained clinical improvement in local skin inflammation. Moreover, the increased frequency of FoxP3+ cells in the skin of patients with AD suggests its immunomodulatory properties. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3351354 Wed, 10 Mar 2010 00:00:00 +0100 3351354 http://www.medworm.com/index.php?rid=3351353&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02355.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3351353 Wed, 10 Mar 2010 00:00:00 +0100 3351353 http://www.medworm.com/index.php?rid=3351352&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02358.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3351352 Wed, 10 Mar 2010 00:00:00 +0100 3351352 http://www.medworm.com/index.php?rid=3336287&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02357.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3336287 Sat, 06 Mar 2010 00:00:00 +0100 3336287 http://www.medworm.com/index.php?rid=3336288&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02344.x Conclusion: Combining [Sigma]-IgE to inhalant allergens and Severity score at 2 years was superior to predict asthma at 10 years than either alone. Severity score predicted CA in both genders, whereas [Sigma]-IgE significantly predicted CA in boys only. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3336288 Fri, 05 Mar 2010 00:00:00 +0100 3336288 http://www.medworm.com/index.php?rid=3312552&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02347.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3312552 Sat, 27 Feb 2010 00:00:00 +0100 3312552 http://www.medworm.com/index.php?rid=3312555&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02331.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3312555 Fri, 26 Feb 2010 00:00:00 +0100 3312555 http://www.medworm.com/index.php?rid=3312554&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02340.x Conclusion: The findings from the present study suggest that PER is characterized by a significantly greater eosinophilic and predominantly Th2 cell-mediated nasal inflammatory profile compared to IAR. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3312554 Fri, 26 Feb 2010 00:00:00 +0100 3312554 http://www.medworm.com/index.php?rid=3312553&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02345.x To cite this article: Rindsjö E, Joerink M, Papadogiannakis N, Scheynius A. IgE in the human placenta: why there? Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02328.x Immunoglobulin E (IgE) antibodies are key effector molecules in the allergic inflammatory response and are also involved in the protection against extracellular parasites. Allergic symptoms often develop early in life, and the intrauterine environment has been proposed to play an important role in affecting the risk of later allergy development. The placenta constitutes a selective barrier between the maternal and foetal circulation. Recently, we reported that maternal IgE antibodies are present on foetal macrophages in the villous tissue of the human placenta irrespective of maternal allergy status. This review discusses the... Allergy journals http://www.medworm.com/rss/comments.php?id=3312553 Fri, 26 Feb 2010 00:00:00 +0100 3312553 http://www.medworm.com/index.php?rid=3295309&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02348.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3295309 Tue, 23 Feb 2010 00:00:00 +0100 3295309 http://www.medworm.com/index.php?rid=3295312&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02264.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3295312 Mon, 22 Feb 2010 00:00:00 +0100 3295312 http://www.medworm.com/index.php?rid=3295311&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02342.x To cite this article: Cummings AJ, Knibb RC, King RM, Lucas JS. The psychosocial impact of food allergy and food hypersensitivity in children, adolescents and their families: a review. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02342.x. Food allergy affects 6% of children but there is no cure, and strict avoidance of index allergens along with immediate access to rescue medication is the current best management. With specialist care, morbidity from food allergy in children is generally low, and mortality is very rare. However, there is strong evidence that food allergy and food hypersensitivity has an impact on psychological distress and on the quality of life (QoL) of children and adolescents, as well as their families. Until recently, the measurement of QoL in allergic children has prov... Allergy journals http://www.medworm.com/rss/comments.php?id=3295311 Mon, 22 Feb 2010 00:00:00 +0100 3295311 http://www.medworm.com/index.php?rid=3295310&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02346.x Conclusions: Sensitization to foods is common but highly variable. The relative prevalence of sensitization to different foods is more consistent than would be expected by chance, suggesting that quantity of consumption of specific foods does not determine prevalence. The aetiology of food sensitization is only partly similar to that for aeroallergens but is related to local levels of total IgE. This may provide an important clue to the origins of food sensitization. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3295310 Mon, 22 Feb 2010 00:00:00 +0100 3295310 http://www.medworm.com/index.php?rid=3260075&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02336.x Conclusions: The results suggest that adding omalizumab to usual care improves QALYs at an increase in direct medical costs. The cost-effectiveness of omalizumab is similar to other chronic disease biologics. The value increases when omalizumab response is used to guide long-term treatment. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3260075 Thu, 11 Feb 2010 00:00:00 +0100 3260075 http://www.medworm.com/index.php?rid=3260077&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02327.x Conclusion: Lymphocyte CCR4 expression is closely associated with induction of human allergen-induced late nasal responses. Blocking CCR4-ligand interaction may provide a novel therapeutic approach in allergic disease. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3260077 Wed, 10 Feb 2010 00:00:00 +0100 3260077 http://www.medworm.com/index.php?rid=3260076&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02332.x To cite this article: Worm M, Timmermans F, Moneret-Vautrin A, Muraro A, Malmheden Yman II, Lövik M, Hattersley S, Crevel R. Towards a European registry of severe allergic reactions: current status of national registries and future needs. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02332.x. The incidence of severe allergic reactions is largely unknown and information about triggering allergens, aggravating factors, demography of patients and medical care is lacking. A European wide registry could provide a powerful tool to improve the management of severe allergic reactions from both a medical and a public health perspective. Analysis of existing registries regarding the type and quality of data being collected was used to develop a plan for a pan-European registry, including the type of ... Allergy journals http://www.medworm.com/rss/comments.php?id=3260076 Wed, 10 Feb 2010 00:00:00 +0100 3260076 http://www.medworm.com/index.php?rid=3255672&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02329.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3255672 Wed, 10 Feb 2010 00:00:00 +0100 3255672 http://www.medworm.com/index.php?rid=3255671&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02330.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3255671 Wed, 10 Feb 2010 00:00:00 +0100 3255671 http://www.medworm.com/index.php?rid=3255670&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02333.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3255670 Wed, 10 Feb 2010 00:00:00 +0100 3255670 http://www.medworm.com/index.php?rid=3255669&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02335.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3255669 Wed, 10 Feb 2010 00:00:00 +0100 3255669 http://www.medworm.com/index.php?rid=3249114&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02325.x Conclusions: This review raises the issue of better consumer protection by recommending that older first-generation H1-antihistamines should no longer be available over-the-counter as prescription- free drugs for self-medication of allergic and other diseases now that newer second- generation nonsedating H1-antihistamines with superior risk/benefit ratios are widely available at competitive prices. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3249114 Mon, 08 Feb 2010 00:00:00 +0100 3249114 http://www.medworm.com/index.php?rid=3249113&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02127.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3249113 Mon, 08 Feb 2010 00:00:00 +0100 3249113 http://www.medworm.com/index.php?rid=3249112&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02328.x Conclusion: Living on a farm and parental allergen sensitization are reflected in the intrauterine environment at the gene expression level. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3249112 Mon, 08 Feb 2010 00:00:00 +0100 3249112 http://www.medworm.com/index.php?rid=3249111&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02334.x Conclusions: IgE analysis to peanut allergen components may be used to distinguish between peanut-sensitized individuals at risk of severe symptoms and those likely to have milder or no symptoms to peanut if sensitized to pollen allergens and their peanut homologue allergens. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3249111 Mon, 08 Feb 2010 00:00:00 +0100 3249111 http://www.medworm.com/index.php?rid=3240705&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02321.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3240705 Fri, 05 Feb 2010 00:00:00 +0100 3240705 http://www.medworm.com/index.php?rid=3240713&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02286.x Conclusion: In general, pollen count and allergen in ambient air follow the same temporal trends. However, because a 10-fold difference can exist in allergen potency of birch pollen, symptoms might be difficult to correlate with pollen counts, but perhaps better with allergen exposure. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3240713 Thu, 04 Feb 2010 00:00:00 +0100 3240713 http://www.medworm.com/index.php?rid=3240712&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02301.x Conclusion: Adults reporting that they had never had asthma were at a substantial risk of new-onset asthma as a result of multiple independent risk factors including lung function. Atopy explains a small proportion of new-onset adult asthma. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3240712 Thu, 04 Feb 2010 00:00:00 +0100 3240712 http://www.medworm.com/index.php?rid=3240711&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02313.x Conclusion: Staphylococcus aureus enterotoxin B exerts a direct pro-inflammatory effect on HNEC, with induction of chemokine and growth factor release, resulting in the migration and prolonged survival of granulocytes in vitro. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3240711 Thu, 04 Feb 2010 00:00:00 +0100 3240711 http://www.medworm.com/index.php?rid=3240710&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2010.02326.x Conclusion: Our results confirm previous observations of altered ceramide levels in AD, which however appear to show no clear relationship with FLG mutations. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3240710 Thu, 04 Feb 2010 00:00:00 +0100 3240710 http://www.medworm.com/index.php?rid=3240709&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02312.x Conclusions: Despite the strong associations between birth order and atopy, reductions in family size in the last 40 years account for little of the increase in atopy. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3240709 Thu, 04 Feb 2010 00:00:00 +0100 3240709 http://www.medworm.com/index.php?rid=3240708&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02316.x Conclusion: A diagnosis of AR was an independent risk factor for asthma in our primary care study population. Having physician-diagnosed AR increased the risk almost fivefold for a future asthma diagnosis. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3240708 Thu, 04 Feb 2010 00:00:00 +0100 3240708 http://www.medworm.com/index.php?rid=3240707&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02319.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3240707 Thu, 04 Feb 2010 00:00:00 +0100 3240707 http://www.medworm.com/index.php?rid=3240706&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02320.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3240706 Thu, 04 Feb 2010 00:00:00 +0100 3240706 http://www.medworm.com/index.php?rid=3225333&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02304.x Conclusion: Disease-specific HRQL questionnaires may be more suitable to measure clinically important impairments in HRQL or HRQL differences over time in food allergic patients. However, generic HRQL questionnaires are indispensable for the comparison between different diseases and are thus complementary. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3225333 Mon, 01 Feb 2010 00:00:00 +0100 3225333 http://www.medworm.com/index.php?rid=3225332&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02305.x To cite this article: Harari S, Caminati A. IPF: new insight on pathogenesis and treatment. Allergy 2010; DOI: 10.1111/j.1398-9995.2009.02305.x. Recent years have seen a robust influx of exciting new observations regarding the mechanisms that regulate the initiation and progression of pulmonary fibrosis but the pathogenesis remains poorly understood. The search for an alternative hypothesis to unremitting, chronic inflammation as the primary explanation for the pathophysiology of idiopathic pulmonary fibrosis (IPF) derives, in part, from the lack of therapeutic efficacy of high-dose immunosuppressive therapy in patients with IPF. The inflammatory hypothesis of IPF has since been challenged by the epithelial injury hypothesis, in which fibrosis is believed to result from epithelial injury, ... Allergy journals http://www.medworm.com/rss/comments.php?id=3225332 Mon, 01 Feb 2010 00:00:00 +0100 3225332 http://www.medworm.com/index.php?rid=3225331&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02307.x Conclusion: CD8+ T cells mediate penicillin skin allergy. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3225331 Mon, 01 Feb 2010 00:00:00 +0100 3225331 http://www.medworm.com/index.php?rid=3225330&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02308.x Conclusions: Mast cell[ndash]BSM cell adhesion involved collagen, CD44, and CD51, particularly under inflammatory conditions. CD44v6 expression is increased in asthmatic BSM cells. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3225330 Mon, 01 Feb 2010 00:00:00 +0100 3225330 http://www.medworm.com/index.php?rid=3225329&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02310.x Conclusion: CARAT10 has high internal consistency and good concurrent validity, making it useful to compare groups in clinical studies. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3225329 Mon, 01 Feb 2010 00:00:00 +0100 3225329 http://www.medworm.com/index.php?rid=3225328&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02302.x Conclusions: Our data confirm serum tryptase as a risk factor for severe anaphylactic reaction to hymenoptera stings. Furthermore, we give first evidence that basal serum tryptase levels increase continuously with age and being an indicator for either increased mast cell load or reactivity this can at least partly be responsible for the observed aggravated allergic reactions in elderly people. As those patients are at increased risk for life-threatening anaphylactic reactions, it should be considered to adjust VIT especially in elderly patients with elevated tryptase levels as recommended for patients with mastocytosis by increasing venom doses during VIT and by considering its life-long continuation. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3225328 Mon, 01 Feb 2010 00:00:00 +0100 3225328 http://www.medworm.com/index.php?rid=3225327&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02317.x Conclusion: A cost-minimization analysis as well as a cost-effectiveness analysis for Germany based on different product price calculations show that BDP/FF fixed combination is superior to BDP + FF delivered via separate inhalers. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3225327 Mon, 01 Feb 2010 00:00:00 +0100 3225327 http://www.medworm.com/index.php?rid=3213480&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02290.x Conclusion: We encourage that these observations be used in the evaluation and treatment of patients with asthma and rhinitis and that they contribute to the understanding of asthma and rhinitis as a uniform airways disease. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3213480 Thu, 28 Jan 2010 00:00:00 +0100 3213480 http://www.medworm.com/index.php?rid=3213479&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02296.x Conclusions: Sputum cells from moderate and refractory asthmatics release less IL-6. While the systemic overproduction of IL-4 was observed through the all spectrum of asthma severity, moderate asthmatics exhibited greater systemic IL-10 production compared to refractory asthmatics. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3213479 Thu, 28 Jan 2010 00:00:00 +0100 3213479 http://www.medworm.com/index.php?rid=3213478&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02303.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3213478 Thu, 28 Jan 2010 00:00:00 +0100 3213478 http://www.medworm.com/index.php?rid=3213477&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02306.x Conclusion: The findings of this pilot study suggest that an extra-fine inhaled combination for the treatment of asthma has beneficial effects on both large and small airways function as expressed by Mch and sbN2 tests. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3213477 Thu, 28 Jan 2010 00:00:00 +0100 3213477 http://www.medworm.com/index.php?rid=3213476&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02311.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3213476 Thu, 28 Jan 2010 00:00:00 +0100 3213476 http://www.medworm.com/index.php?rid=3213475&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02318.x Conclusions: The contribution of skin testing with PPL and MDM in diagnosing nonimmediate hypersensitivity reactions to penicillins, especially cell-mediated ones, is very limited. This finding could be useful at a time when PPL and MDM are not available in all countries. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3213475 Thu, 28 Jan 2010 00:00:00 +0100 3213475 http://www.medworm.com/index.php?rid=3213474&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02322.x Conclusion: The longer duration of the ruptured fetal membranes possibly reflected the higher risk of intrapartum infection at birth, and further increased the risk of doctor-diagnosed wheezing among offspring. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3213474 Thu, 28 Jan 2010 00:00:00 +0100 3213474 http://www.medworm.com/index.php?rid=3213473&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02323.x Conclusion: This study is the first to show the development of an allergen-specific IL-4 response in adult human subjects during allergen-specific sensitization. This IL-4 response was quantitatively associated with the development of the specific IgE antibodies. Allergen-specific or nonspecific IL-10 and IFN[gamma] responses showed no protective effect on the development of allergic sensitization. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3213473 Thu, 28 Jan 2010 00:00:00 +0100 3213473 http://www.medworm.com/index.php?rid=3198770&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02299.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3198770 Sat, 23 Jan 2010 00:00:00 +0100 3198770 http://www.medworm.com/index.php?rid=3198772&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02265.x We present here examples from Finland, Poland and Brazil, to show that asthma burden can be reduced using varied strategies in quite different societal, economical and health care environments. The experience from those interventions confirms that regardless of the health care system and its coverage, a major change for the better can be achieved by local efforts, systematic planning and networking to implement the best asthma practice. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3198772 Fri, 22 Jan 2010 00:00:00 +0100 3198772 http://www.medworm.com/index.php?rid=3198771&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02267.x Conclusions: Higher maternal consumption of green and yellow vegetables, citrus fruit, and [beta]-carotene during pregnancy may be protective against the development of eczema in the offspring. Higher maternal vitamin E intake during pregnancy may reduce the risk of infantile wheeze. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3198771 Fri, 22 Jan 2010 00:00:00 +0100 3198771 http://www.medworm.com/index.php?rid=3107246&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02283.x Conclusions: The international pattern of discordance between SPT and sIgE results did not support the downregulation hypothesis. Among children with no evidence of sensitization to common aeroallergens, increased total IgE contributes little to the risk of wheeze and rhinitis in the general population but may play a role in eczema. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3107246 Mon, 21 Dec 2009 00:00:00 +0100 3107246 http://www.medworm.com/index.php?rid=3107245&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02291.x Conclusion: This is the first study showing across three cohorts that X-chromosomal FOXP3 genotypes may contribute to development of sensitisation against egg and indoor allergens in girls in early childhood. In addition, an association with remission of sensitisation to food allergens existed in boys only. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3107245 Mon, 21 Dec 2009 00:00:00 +0100 3107245 http://www.medworm.com/index.php?rid=3107244&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02292.x To cite this article: Calderon M, Mösges R, Hellmich M, Demoly P. Towards evidence-based medicine in specific grass pollen immunotherapy. Allergy 2009; DOI: 10.1111/j.1398-9995.2009.02292.x. When initiating grass pollen immunotherapy for seasonal allergic rhinoconjunctivitis, specialist physicians in many European countries must choose between modalities of differing pharmaceutical and regulatory status. We applied an evidence-based medicine (EBM) approach to commercially available subcutaneous and sublingual Gramineae grass pollen immunotherapies (SCIT and SLIT) by evaluating study design, populations, pollen seasons, treatment doses and durations, efficacy, quality of life, safety and compliance. After searching MEDLINE, Embase and the Cochrane Library up until January 2009, we identifi... Allergy journals http://www.medworm.com/rss/comments.php?id=3107244 Mon, 21 Dec 2009 00:00:00 +0100 3107244 http://www.medworm.com/index.php?rid=3107243&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02294.x To cite this article: Kastner M, Harada L, Waserman S. Gaps in anaphylaxis management at the level of physicians, patients, and the community: a systematic review of the literature. Allergy 2009; DOI: 10.1111/j.1398-9995.2009.02294.x. Diagnosis and management of anaphylaxis can be a challenge because reactions are often unexpected and progress quickly. The focus of anaphylaxis management has mostly been on the acute episode, with little attention given to the long-term management of patients at risk. This is compounded by conflicting information in current guidelines and a general lack of agreement among clinicians about which management strategies are the most appropriate. We systematically reviewed the literature to identify and summarize studies that investigated gaps in anaphylaxis man... Allergy journals http://www.medworm.com/rss/comments.php?id=3107243 Mon, 21 Dec 2009 00:00:00 +0100 3107243 http://www.medworm.com/index.php?rid=3107242&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02295.x Conclusions: We conclude that SIT suppresses the skewed Th2 responses via disrupting the interaction of TIM1/TIM4 in antigen-specific Th2 cells. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3107242 Mon, 21 Dec 2009 00:00:00 +0100 3107242 http://www.medworm.com/index.php?rid=3107241&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02297.x Conclusions: These results suggest that FCER1A variants by themselves and in combination influence IgE levels and act synergistically to influence eczema risk. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3107241 Mon, 21 Dec 2009 00:00:00 +0100 3107241 http://www.medworm.com/index.php?rid=3097455&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02298.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3097455 Fri, 18 Dec 2009 00:00:00 +0100 3097455 http://www.medworm.com/index.php?rid=3097456&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02289.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3097456 Thu, 17 Dec 2009 00:00:00 +0100 3097456 http://www.medworm.com/index.php?rid=3093342&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02288.x Discussion: Our results indicate that OA because of ammonium persulphate coexists with occupational rhinitis in half of the patients. Unexpectedly, rhinitis did not seem to have an impact on the natural history of asthma. The finding of nasal inflammation in subjects with OA-only without clinical manifestations of rhinitis supports the united airway disease concept in occupational respiratory allergy as a result of persulphates. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3093342 Thu, 17 Dec 2009 00:00:00 +0100 3093342 http://www.medworm.com/index.php?rid=3093343&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02287.x Conclusions: There are marked inter-racial differences in the relationship between serum cholesterol and atopy in the US population. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3093343 Wed, 16 Dec 2009 00:00:00 +0100 3093343 http://www.medworm.com/index.php?rid=3080180&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02293.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3080180 Sat, 12 Dec 2009 00:00:00 +0100 3080180 http://www.medworm.com/index.php?rid=3080183&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02270.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3080183 Fri, 11 Dec 2009 00:00:00 +0100 3080183 http://www.medworm.com/index.php?rid=3080182&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02282.x Conclusions: This study suggests that markers of eosinophilic, but not neutrophilic inflammation, are increased in asthmatic children and also in atopic children without asthma. Of interest, in asthmatic children, the activation of the eosinophilic response is not solely because of the presence of atopy. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3080182 Fri, 11 Dec 2009 00:00:00 +0100 3080182 http://www.medworm.com/index.php?rid=3080181&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02284.x Conclusions: Acupuncture at the correct points showed a significant reduction in type I hypersensitivity itch in patients with atopic eczema. With time the preventive point-specific effect diminished with regard to subjective itch sensation, whereas it increased in suppressing skin-prick reactions. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3080181 Fri, 11 Dec 2009 00:00:00 +0100 3080181 http://www.medworm.com/index.php?rid=3053576&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02277.x Conclusions: Mor n 3 is the first allergen isolated in black mulberry and immunologically characterized. It displayed allergenic activity among symptomatic and nonconsumer patients and a pattern of cross-reactivity to other plant-derived LTPs. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3053576 Fri, 04 Dec 2009 00:00:00 +0100 3053576 http://www.medworm.com/index.php?rid=3053580&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02273.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3053580 Thu, 03 Dec 2009 00:00:00 +0100 3053580 http://www.medworm.com/index.php?rid=3053579&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02274.x To cite this article: Quirce S, Lemière C, de Blay F, del Pozo V, Gerth Van Wijk R, Maestrelli P, Pauli G, Pignatti P, Raulf-Heimsoth M, Sastre J, Storaas T, Moscato G. Noninvasive methods for assessment of airway inflammation in occupational settings. Allergy 2009; DOI: 10.1111/j.1398-9995.2009.02274.x The present document is a consensus statement reached by a panel of experts on noninvasive methods for assessment of airway inflammation in the investigation of occupational respiratory diseases, such as occupational rhinitis, occupational asthma, and nonasthmatic eosinophilic bronchitis. Both the upper and the lower airway inflammation have been reviewed and appraised reinforcing the concept of 'united airway disease' in the occupational settings. The most widely used noninvasive methods ... Allergy journals http://www.medworm.com/rss/comments.php?id=3053579 Thu, 03 Dec 2009 00:00:00 +0100 3053579 http://www.medworm.com/index.php?rid=3053578&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02275.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3053578 Thu, 03 Dec 2009 00:00:00 +0100 3053578 http://www.medworm.com/index.php?rid=3053577&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02276.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3053577 Thu, 03 Dec 2009 00:00:00 +0100 3053577 http://www.medworm.com/index.php?rid=3034769&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02281.x Conclusions: The present data demonstrate that parasympathetic activity has the capacity to activate dendritic cells to release OX40 ligand, the latter induces CD4(+) T cells to produce IL-4 and TNF-alpha that may further contribute to the pathogenesis of NP. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3034769 Sat, 28 Nov 2009 00:00:00 +0100 3034769 http://www.medworm.com/index.php?rid=3034770&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02280.x Conclusions: This report indicates that in some patients with infliximab-related severe reactions, IgE or IgM antibodies against infliximab were detectable. The majority of reactions could be predicted by the appearance of anti-infliximab antibodies. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3034770 Fri, 27 Nov 2009 00:00:00 +0100 3034770 http://www.medworm.com/index.php?rid=3027380&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02269.x Conclusion: In Sweden, the cost of rhinitis is [euro] 2.7 billion a year in terms of lost productivity. A reduction in lost productivity of 1 day per individual and year would potentially save [euro] 528 million. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3027380 Thu, 26 Nov 2009 00:00:00 +0100 3027380 http://www.medworm.com/index.php?rid=3027379&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02278.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3027379 Thu, 26 Nov 2009 00:00:00 +0100 3027379 http://www.medworm.com/index.php?rid=3027378&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02279.x Conclusion: Our findings show that LC express a functional H4R and point towards a possible pathogenic relevance of the H4R in inflammatory and allergic diseases. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3027378 Thu, 26 Nov 2009 00:00:00 +0100 3027378 http://www.medworm.com/index.php?rid=3027377&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02285.x Conclusion: This preliminary study provided evidence that IL-10 and IFN-[gamma] production could be defective in allergic children prone to develop polysensitization. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3027377 Thu, 26 Nov 2009 00:00:00 +0100 3027377 http://www.medworm.com/index.php?rid=3027376&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02271.x Conclusion: CD34+ cells in blood and BM are capable of producing IL-5 both in vitro and in vivo in humans, arguing that these cells may have the capacity to contribute to eosinophilic inflammation. Consequently, targeting CD34+ progenitor cells that produce and release IL-5 may be effective in reducing the mobilization of eosinophil lineage-committed cells in eosinophilic-driven diseases. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3027376 Thu, 26 Nov 2009 00:00:00 +0100 3027376 http://www.medworm.com/index.php?rid=3027384&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02111.x Conclusion: Our unbiased approach provided suggestive evidence for interaction between several TLR-related pathway genes important in atopy and/or asthma development and pointed to novel genes. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3027384 Wed, 25 Nov 2009 00:00:00 +0100 3027384 http://www.medworm.com/index.php?rid=3027383&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02245.x Conclusions: The combination of minor determinants of amoxicillin, amoxicilloic acid, and diketopiperazine seems to be of no greater value than the use of amoxicillin alone. Further efforts are needed to find new structures to improve sensitivity in the diagnosis of immediate hypersensitivity to betalactams. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3027383 Wed, 25 Nov 2009 00:00:00 +0100 3027383 http://www.medworm.com/index.php?rid=3027382&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02252.x Conclusions: Our study provides the first evidence that both IL-17F and IL-25 can be induced by dsRNA in HNECs. Despite of the opposing effects of IL-17A and IL-25 on TSLP regulation in HNECs, IL-25 was dominant to IL-17A, providing a plausible explanation for the simultaneous upregulation of IL-17 cytokines and TSLP in patients with AR. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3027382 Wed, 25 Nov 2009 00:00:00 +0100 3027382 http://www.medworm.com/index.php?rid=3027381&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02260.x Conclusions: Gene[ndash]gene (e.g. immune and redox genes) and gene[ndash]environment (e.g. maternal atopy and FGF1or redox genes) interactions on IgE production begin in prenatal stage, suggesting that prevention of IgE-mediated diseases may be made possible by control of maternal atopy and redox responses in prenatal stage. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3027381 Wed, 25 Nov 2009 00:00:00 +0100 3027381 http://www.medworm.com/index.php?rid=3019689&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02268.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3019689 Tue, 24 Nov 2009 00:00:00 +0100 3019689 http://www.medworm.com/index.php?rid=3019690&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02266.x Conclusion: Our results suggest that maternal allergic disease has no effect on the neonatal response to allergens or the phenotype of neonatal lymphocytes. The factors studied here could, however, still affect later development of allergy. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3019690 Mon, 23 Nov 2009 00:00:00 +0100 3019690 http://www.medworm.com/index.php?rid=3013515&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02263.x The aim of this Global Allergy and Asthma European Network (GA2LEN) consensus report is to provide recommendations for patient-reported outcomes (PROs) evaluation in clinical trials for allergic diseases, which constitute a global health problem in terms of physical, psychological economic and social impact. During the last 40 years, PROs have gained large consideration and use in the scientific community, to gain a better understanding of patients' subjective assessment with respect to elements concerning their health condition. They include all health-related reports coming from the patient, without involvement or interpretation by physician or others. PROs assessment should be performed by validated tools (disease-specific tools when available or generic ones) selected taking into accou... Allergy journals http://www.medworm.com/rss/comments.php?id=3013515 Sat, 21 Nov 2009 00:00:00 +0100 3013515 http://www.medworm.com/index.php?rid=3013517&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02256.x Conclusion: Although no accelerated loss in FEV1 was documented in these workers exposed to chlorine, subjects with a greater fall in FEV1 were more likely to report cough and have higher levels of total glutathione at Vb. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=3013517 Fri, 20 Nov 2009 00:00:00 +0100 3013517 http://www.medworm.com/index.php?rid=3013516&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02248.x Patent blue V is widely used in the identification of sentinel lymph nodes in patients with breast cancer and other malignancies. Individual case reports of allergy to patent blue V have been described in the medical literature since the 1960s. However, there is little data on clinical features and little experience of which allergy tests are appropriate or useful. We gathered all cases of patent blue V allergy that had been seen and diagnosed in the Department of Allergy, Addenbrooke's Hospital over a 3-year period. We collected clinical details of each case including skin test results. For comparison we recruited 12 healthy control subjects who then underwent skin testing to patent blue V. Six cases of patent blue V allergy were identified, all occurring during sentinel lymph node identi... Allergy journals http://www.medworm.com/rss/comments.php?id=3013516 Fri, 20 Nov 2009 00:00:00 +0100 3013516 http://www.medworm.com/index.php?rid=2985979&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02251.x Egg allergy is one of the most frequent food allergies in children below the age of three. Common symptoms of egg allergy involve frequently the skin as well as the gut and in more severe cases result in anaphylaxis. Non-IgE-mediated symptoms such as in eosinophilic diseases of the gut or egg-induced enterocolitis might also be observed. Sensitization to egg white proteins can be found in young children in absence of clinical symptoms. The diagnosis of egg allergy is based on the history, IgE tests as well as standardized food challenges. Ovomucoid is the major allergen of egg, and recent advances in technology have improved the diagnosis and follow-up of patients with egg allergy by using single allergens or allergens with modified allergenic properties. Today, the management of egg aller... Allergy journals http://www.medworm.com/rss/comments.php?id=2985979 Fri, 13 Nov 2009 00:00:00 +0100 2985979 http://www.medworm.com/index.php?rid=2985980&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02244.x Asthma prevalence has increased very considerably in recent decades such that it is now one of the commonest chronic disorders in the world. Recent evidence from epidemiological studies, however, suggests that the prevalence of asthma may now be declining in many parts of the world, which, if true is important for health service planning and also because this offers the possibility of generating and testing new aetiological hypotheses. Our objective was to determine whether the prevalence of asthma is declining worldwide. We undertook a systematic search of EMBASE, Medline, Web of Science and Google Scholar, for high quality reports of cohort studies, repeat cross-sectional studies and analyses of routine healthcare datasets to examine international trends in asthma prevalence in children ... Allergy journals http://www.medworm.com/rss/comments.php?id=2985980 Thu, 12 Nov 2009 00:00:00 +0100 2985980 http://www.medworm.com/index.php?rid=2982250&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02253.x Conclusion: We found evidence that the allergy-protecting effects of A. lwoffii F78 are because of the activation of a TH1-polarizing program in human dendritic cells, and that the LPS of A. lwoffii F78 is responsible for these beneficial effects. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2982250 Thu, 12 Nov 2009 00:00:00 +0100 2982250 http://www.medworm.com/index.php?rid=2982254&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02254.x Conclusions: We suggest that PEA is an endogenous protective agent against DNFB-induced keratinocyte inflammation and could be considered for therapeutic use against CAD. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2982254 Wed, 11 Nov 2009 00:00:00 +0100 2982254 http://www.medworm.com/index.php?rid=2982253&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02242.x The involvement of small airways in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) has been debated for a long time. However, a proper definition of small airway disease is still lacking, and neither a widely accepted biomarker nor a functional parameter to assess small airway abnormalities and to explore the effect of tested compounds on small airways is available. Aiming towards increased knowledge and consensus on this topic, this perspective paper intends to (i) strengthen awareness among the scientific community on the role of small airways in asthma and COPD; (ii) examine the pros and cons of some biological, functional and imaging parameters in the assessment of small airway abnormalities; and (iii) discuss the evidence for distal airway pharmacological ... Allergy journals http://www.medworm.com/rss/comments.php?id=2982253 Wed, 11 Nov 2009 00:00:00 +0100 2982253 http://www.medworm.com/index.php?rid=2982252&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02243.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2982252 Wed, 11 Nov 2009 00:00:00 +0100 2982252 http://www.medworm.com/index.php?rid=2982251&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02250.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2982251 Wed, 11 Nov 2009 00:00:00 +0100 2982251 http://www.medworm.com/index.php?rid=2960197&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02262.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2960197 Thu, 05 Nov 2009 00:00:00 +0100 2960197 http://www.medworm.com/index.php?rid=2960203&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02214.x Conclusions: This will be the first comparative study of the epidemiology of food allergies in China, India, and Russia using the same standardized methodology. The findings of these surveys will complement the data obtained from Europe and provide insights into the development of food allergy. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2960203 Wed, 04 Nov 2009 00:00:00 +0100 2960203 http://www.medworm.com/index.php?rid=2960202&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02255.x Conclusion: IL-31 induces pro-inflammatory effects in activated human monocytes and macrophages. This may have implications for cutaneous inflammation in eczema where an over-expression of IL-31 has been described previously. Moreover, our findings provide a new link between staphylococcal colonization and the worsening of inflammation via IL-31. Further therapeutic considerations may include IL-31 as a target in AD. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2960202 Wed, 04 Nov 2009 00:00:00 +0100 2960202 http://www.medworm.com/index.php?rid=2960201&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02257.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2960201 Wed, 04 Nov 2009 00:00:00 +0100 2960201 http://www.medworm.com/index.php?rid=2960200&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02258.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2960200 Wed, 04 Nov 2009 00:00:00 +0100 2960200 http://www.medworm.com/index.php?rid=2960199&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02259.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2960199 Wed, 04 Nov 2009 00:00:00 +0100 2960199 http://www.medworm.com/index.php?rid=2960198&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02261.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2960198 Wed, 04 Nov 2009 00:00:00 +0100 2960198 http://www.medworm.com/index.php?rid=2955828&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02236.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2955828 Wed, 04 Nov 2009 00:00:00 +0100 2955828 http://www.medworm.com/index.php?rid=2955834&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02225.x Conclusion: Compensatory regulatory T-cell function becomes critical in pIgR-deficient mice to avoid the potentially catastrophic effects of systemic immune hyperreactivity, presumably resulting from defective secretory antibody-mediated immune exclusion of microbial components. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2955834 Tue, 03 Nov 2009 00:00:00 +0100 2955834 http://www.medworm.com/index.php?rid=2955833&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02226.x Conclusion: Our results show that asthma is associated with a higher rate of sweating response to exercise in boys, and anti-inflammatory treatment decreases the amount of sweating. The relationship of eccrine sweating with muscarinic receptor response and methacholine hyperresponsiveness remains to be determined. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2955833 Tue, 03 Nov 2009 00:00:00 +0100 2955833 http://www.medworm.com/index.php?rid=2955832&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02229.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2955832 Tue, 03 Nov 2009 00:00:00 +0100 2955832 http://www.medworm.com/index.php?rid=2955831&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02231.x Conclusions: No direct correlation was evidenced between IgE profile and the degree of sensitization even though 2 spectrotypes could be distinguished. Our data contribute to a better delineation of ash pollen allergens and patterns of sensitization. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2955831 Tue, 03 Nov 2009 00:00:00 +0100 2955831 http://www.medworm.com/index.php?rid=2955830&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02234.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2955830 Tue, 03 Nov 2009 00:00:00 +0100 2955830 http://www.medworm.com/index.php?rid=2955829&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02235.x Conclusion: The establishment of a quality management system with joint standards of care and harmonized procedures can be achieved in an international health network and ensures quality of care. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2955829 Tue, 03 Nov 2009 00:00:00 +0100 2955829 http://www.medworm.com/index.php?rid=2951552&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02249.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2951552 Tue, 03 Nov 2009 00:00:00 +0100 2951552 http://www.medworm.com/index.php?rid=2951558&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02237.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2951558 Mon, 02 Nov 2009 00:00:00 +0100 2951558 http://www.medworm.com/index.php?rid=2951557&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02238.x Conclusion: In subjects inadequately controlled by symptomatic medications, grass AIT provided sustained and clinically relevant improvements in rhinoconjunctivitis quality of life compared to placebo. The effect increased with increasing grass pollen exposure. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2951557 Mon, 02 Nov 2009 00:00:00 +0100 2951557 http://www.medworm.com/index.php?rid=2951556&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02239.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2951556 Mon, 02 Nov 2009 00:00:00 +0100 2951556 http://www.medworm.com/index.php?rid=2951555&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02240.x Conclusion: Because chronic allergic contact dermatitis is developed by H4 receptor stimulation, H4 receptor antagonists might represent new candidate drugs for treating chronic allergic contact dermatitis. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2951555 Mon, 02 Nov 2009 00:00:00 +0100 2951555 http://www.medworm.com/index.php?rid=2951554&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02241.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2951554 Mon, 02 Nov 2009 00:00:00 +0100 2951554 http://www.medworm.com/index.php?rid=2951553&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02247.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2951553 Mon, 02 Nov 2009 00:00:00 +0100 2951553 http://www.medworm.com/index.php?rid=2928144&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02233.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2928144 Tue, 27 Oct 2009 00:00:00 +0100 2928144 http://www.medworm.com/index.php?rid=2928149&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02209.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2928149 Mon, 26 Oct 2009 00:00:00 +0100 2928149 http://www.medworm.com/index.php?rid=2928148&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02227.x Conclusion: We provide unprecedented genetic evidence suggesting a role for the IL33 pathway in the pathogenesis of NP. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2928148 Mon, 26 Oct 2009 00:00:00 +0100 2928148 http://www.medworm.com/index.php?rid=2928147&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02228.x Conclusion: Although the negative predictive value of drug provocation tests may not be 100%, none of the false negative patients experienced a life-threatening reaction. This should reassure doctors who might hesitate to prescribe beta-lactams, even in patients with negative allergic work-ups. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2928147 Mon, 26 Oct 2009 00:00:00 +0100 2928147 http://www.medworm.com/index.php?rid=2928146&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02230.x Conclusions: Major mite allergen Der f 1 preferentially accumulates in buildings not specifically designed for low energy use, reaching levels at risk for sensitization. We hypothesize that controlled mechanical ventilation present in all audited LEB may favour lower air humidity and hence lower mite growth and allergen concentration, while preserving optimal perceived comfort. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2928146 Mon, 26 Oct 2009 00:00:00 +0100 2928146 http://www.medworm.com/index.php?rid=2928145&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02232.x The methodology of randomized clinical trials is essential for the critical assessment and registration of therapeutic interventions. The CONSORT (Consolidated Standards of Reporting Trials) statement was developed to alleviate the problems arising from the inadequate reporting of randomized controlled trials. The present article reflects on the items that we believe should be included in the CONSORT checklist in the context of conducting and reporting trials in allergen-specific immunotherapy. Only randomized, blinded (in particular blinding of patients, health care providers, and outcome assessors), placebo-controlled Phase III studies in this article. Our analysis focuses on the definition of patients' inclusion and exclusion criteria, allergen standardization, primary, secondary and ex... Allergy journals http://www.medworm.com/rss/comments.php?id=2928145 Mon, 26 Oct 2009 00:00:00 +0100 2928145 http://www.medworm.com/index.php?rid=2921208&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02217.x Conclusions: Bilastine 20 mg is a novel effective and safe treatment option for the management of CU. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2921208 Fri, 23 Oct 2009 23:00:00 +0100 2921208 http://www.medworm.com/index.php?rid=2917206&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02210.x Conclusion: In our population-based sample of children, we found a link between Alternaria sensitization and allergic rhinitis, independently of asthma, which is compatible with the mechanisms of deposition of Alternaria in the upper airways. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2917206 Thu, 22 Oct 2009 23:00:00 +0100 2917206 http://www.medworm.com/index.php?rid=2913458&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02223.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2913458 Wed, 21 Oct 2009 23:00:00 +0100 2913458 http://www.medworm.com/index.php?rid=2913459&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02216.x Conclusions: Food allergy independent measures were developed for children, adolescents and adults and were shown to be valid, relevant and reliable. This supports the suitability of the FAIMs for evaluating construct validity. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2913459 Tue, 20 Oct 2009 23:00:00 +0100 2913459 http://www.medworm.com/index.php?rid=2905741&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02213.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2905741 Mon, 19 Oct 2009 23:00:00 +0100 2905741 http://www.medworm.com/index.php?rid=2905740&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02215.x Conclusions: Overall there were no clear relations between dietary patterns and adult asthma; associations in nonsupplement users and whites require confirmation. The finding for chronic bronchitis was unexpected and also requires replication. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2905740 Mon, 19 Oct 2009 23:00:00 +0100 2905740 http://www.medworm.com/index.php?rid=2905739&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02218.x Conclusion: Despite an increase in CD4+CD25bright cells expressing high levels of FOXP3 in response to bronchial allergen provocation, asthmatic patients exhibit enhanced levels of Th2 cytokines in the lung, which may indicate an inability among infiltrating cells to suppress Th2 responses. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2905739 Mon, 19 Oct 2009 23:00:00 +0100 2905739 http://www.medworm.com/index.php?rid=2905738&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02220.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2905738 Mon, 19 Oct 2009 23:00:00 +0100 2905738 http://www.medworm.com/index.php?rid=2905737&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02221.x Conclusion: Alveolar and exhaled NO fractions are not indexes of control or severity in asthmatic children and adults under treatment. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2905737 Mon, 19 Oct 2009 23:00:00 +0100 2905737 http://www.medworm.com/index.php?rid=2905736&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02222.x Conclusions: The measurement of plasma FDP, d-dimer and serum CRP may be useful for the assessment of disease activity of CU. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2905736 Mon, 19 Oct 2009 23:00:00 +0100 2905736 http://www.medworm.com/index.php?rid=2891924&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02080.x Conclusions: FLG mutations are associated both with atopic and nonatopic eczema starting in the first year of life. FLG mutations combined with eczema in the first year of life are associated with a later development of asthma and hay fever, a clear example of the atopic march. We confirm that cat exposure enhances the effect of a FLG mutation on the development of eczema and sensitization. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2891924 Wed, 14 Oct 2009 23:00:00 +0100 2891924 http://www.medworm.com/index.php?rid=2891923&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02199.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2891923 Wed, 14 Oct 2009 23:00:00 +0100 2891923 http://www.medworm.com/index.php?rid=2891922&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02200.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2891922 Wed, 14 Oct 2009 23:00:00 +0100 2891922 http://www.medworm.com/index.php?rid=2891921&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02201.x Asthma is a chronic inflammatory disease of the airways in which immunoglobulin E (IgE) plays a key role by activating a variety of inflammatory cells through interactions with FcɛRI and FcɛRII receptors. The role of IgE in allergic inflammation provided the rationale for developing omalizumab, a humanized monoclonal anti-IgE antibody, for patients with moderate-to-severe or severe allergic asthma. The reductions in circulating levels of IgE resulting from omalizumab treatment leads to reductions in FcɛRI expression on mast cells, basophils and dendritic cells. This combined effect results in attenuation of several markers of inflammation, including peripheral and bronchial tissue eosinophilia and levels of granulocyte macrophage colony stimulating factor, interleukin ... Allergy journals http://www.medworm.com/rss/comments.php?id=2891921 Wed, 14 Oct 2009 23:00:00 +0100 2891921 http://www.medworm.com/index.php?rid=2891920&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02203.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2891920 Wed, 14 Oct 2009 23:00:00 +0100 2891920 http://www.medworm.com/index.php?rid=2891919&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02211.x Conclusion: In this study, CVID patients testing negative for specific IgE antibodies and suspected of having allergic asthma presented a positive response to bronchial provocation tests with allergens. To our knowledge, this is the first such study. When CVID patients with a history suggestive of allergic asthma test negative on traditional tests, additional tests designed to identify allergic asthma might be conducted. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2891919 Wed, 14 Oct 2009 23:00:00 +0100 2891919 http://www.medworm.com/index.php?rid=2883675&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02208.x Smoking is one of the most important preventable public health problems. Prevalence of smoking is decreasing in the Western world but lot of work is left. We reviewed the most important papers related to smoking and asthma. Despite of decreasing smoking figures in Finland, about 15[ndash]20 per cent of pregnant women smokes. Children's exposure to harmful effects of environmental tobacco smoke (ETS) still continues. Exposure to tobacco smoke during pregnancy and in early childhood both deteriorates permanently children's lungs and increases their asthma risk. The exposure of adults to ETS also increases their asthma risk. Both passive exposure to ETS and active smoking worsen asthma. In addition, smoking asthmatics run a higher risk of developing COPD compared to non-smokers. Smoking preva... Allergy journals http://www.medworm.com/rss/comments.php?id=2883675 Mon, 12 Oct 2009 23:00:00 +0100 2883675 http://www.medworm.com/index.php?rid=2881591&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02082.x Allergic contact dermatitis (ACD), one of the commonest occupational diseases, is a T-cell-mediated skin inflammation caused by repeated skin exposure to contact allergens, i.e. nonprotein chemicals called haptens. Allergic contact dermatitis, also referred to as contact hypersensitivity, is mediated by CD8+ T cells, which are primed in lymphoid organs during the sensitization phase and are recruited in the skin upon re-exposure to the hapten. Subsets of CD4+ T cells endowed with suppressive activity are responsible for both the down-regulation of eczema in allergic patients and the prevention of priming to haptens in nonallergic individuals. Therefore, ACD should be considered as a breakdown of the skin immune tolerance to haptens. Recent advances in the pathophysiology of ACD have demons... Allergy journals http://www.medworm.com/rss/comments.php?id=2881591 Sun, 11 Oct 2009 23:00:00 +0100 2881591 http://www.medworm.com/index.php?rid=2881590&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02198.x Conclusions: Bee VIT is effective in most patients immediately after the conventional MD has been reached. In the minority of patients who are not protected with this dose, an increased MD will provide appropriate protection immediately after it is achieved. Thus, the dosage of the MD seems to be the major factor affecting protection from re-stings rather than the accumulated venom dose or the duration on the MD. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2881590 Sun, 11 Oct 2009 23:00:00 +0100 2881590 http://www.medworm.com/index.php?rid=2881589&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02202.x Conclusions: IgE reactivity to recombinant marker allergens is associated with clinical phenotypes of allergic sensitization and may be useful for the selection of treatment strategies. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2881589 Sun, 11 Oct 2009 23:00:00 +0100 2881589 http://www.medworm.com/index.php?rid=2881588&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02204.x Conclusion: These data suggest that in immunologically activated nasal polyp tissue, PGD2 produced by mast cells promotes the migration of Th2 cells through a CRTH2 dependent mechanism. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2881588 Sun, 11 Oct 2009 23:00:00 +0100 2881588 http://www.medworm.com/index.php?rid=2881587&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02205.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2881587 Sun, 11 Oct 2009 23:00:00 +0100 2881587 http://www.medworm.com/index.php?rid=2881586&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02206.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2881586 Sun, 11 Oct 2009 23:00:00 +0100 2881586 http://www.medworm.com/index.php?rid=2881585&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02212.x Background: Wheezing in early childhood is a heterogeneous condition, the long-term prognosis varying from total recovery to chronic asthma. Though short-term outcome has been actively studied, there is lack of data on long-term outcome until adulthood. The aim of the study was to evaluate the prevalence and risk factors of asthma at 26[ndash]29 years of age after early-life wheezing.Methods: At the median age of 27.3 years (range 26.3[ndash]28.6), a questionnaire was sent to 78 study subjects hospitalized for wheezing at (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2881585 Sun, 11 Oct 2009 23:00:00 +0100 2881585 http://www.medworm.com/index.php?rid=2881584&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02219.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2881584 Sun, 11 Oct 2009 23:00:00 +0100 2881584 http://www.medworm.com/index.php?rid=2873170&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02165.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2873170 Thu, 08 Oct 2009 23:00:00 +0100 2873170 http://www.medworm.com/index.php?rid=2863396&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02189.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2863396 Mon, 05 Oct 2009 23:00:00 +0100 2863396 http://www.medworm.com/index.php?rid=2863408&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02146.x Conclusions: Our data suggest that reduced TH-2 type inflammation in DIA after inhaled steroid medication is reflected as elevated MMP-9 and MMP-9/TIMP-1 levels in BAL. MIF may be the inducer of MMP-9. This might point to some protective role for MMP-9 in DIA. (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2863408 Sun, 04 Oct 2009 23:00:00 +0100 2863408 http://www.medworm.com/index.php?rid=2863407&cid=s_33170_3_f&fid=33170&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1398-9995.2009.02147.x (Source: Allergy) Allergy journals http://www.medworm.com/rss/comments.php?id=2863407 Sun, 04 Oct 2009 23:00:00 +0100 2863407