MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Am J Physiol Gastroi...' source. Wed, 08 Feb 2012 16:28:09 +0100 http://www.medworm.com/index.php?rid=5627379&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222012%252F01%252F19%252020.54%2522%255BMHDA%255D%253A%25222012%252F01%252F25%252018.42%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222012%252F01%252F19%252020.54%2522%255BEDAT%255D%29%29 22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2012/01/25PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5627379 Wed, 25 Jan 2012 23:42:01 +0100 5627379 http://www.medworm.com/index.php?rid=5607380&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22241856%26dopt%3DAbstract CONCLUSIONS: MS impairs the adaptation response of gastrointestinal motility following CHS. The mechanism of the impaired adaptation involves down-regulation of OXT and up-regulation of CRF in the hypothalamus in MS rats. PMID: 22241856 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5607380 Thu, 12 Jan 2012 05:00:00 +0100 5607380 http://www.medworm.com/index.php?rid=5607379&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22241857%26dopt%3DAbstract Authors: Rattan S, Singh J Abstract The knowledge of molecular control mechanisms underlying the basal tone in the intact human IAS is critical for the pathophysiology and rational therapy for a number of debilitating rectoanal motility disorders. We determined the role of RhoA/ROCK and PKC pathways by comparing the effects of ROCK and PKC-selective inhibitors Y 27632 and Gö 6850 (10(-8) to 10(-4) M), respectively on the basal tone in the IAS vs. the RSM. Western blot studies were performed to determine the levels of RhoA/ROCKII, PKCα, MYPT1, CPI-17, and MLC(20) in the unphosphorylated and phosphorylated forms, in the IAS vs. RSM. Confocal microscopic studies validated the membrane distribution of ROCK II. Finally, in order to confirm a direct relationship, we examined the enzyma... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5607379 Thu, 12 Jan 2012 05:00:00 +0100 5607379 http://www.medworm.com/index.php?rid=5607378&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22241858%26dopt%3DAbstract Authors: Storey SM, McIntosh AL, Huang H, Landrock KK, Martin GG, Landrock D, Payne HR, Atshaves BP, Kier AB, Schroeder F Abstract A major gap in our knowledge of rapid hepatic high density lipoprotein (HDL) cholesterol clearance is the role of key intracellular factors that influence this process. Although the reverse cholesterol transport (RCT) pathway targets HDL to the liver for net elimination of free cholesterol from the body, molecular details governing cholesterol uptake into hepatocytes are not completely understood. Therefore, the effects of sterol carrier protein-2 (SCP2) and liver fatty acid binding protein (L-FABP), high-affinity cholesterol-binding proteins present in hepatocyte cytosol, HDL-mediated free cholesterol uptake were examined using gene targeted mouse mode... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5607378 Thu, 12 Jan 2012 05:00:00 +0100 5607378 http://www.medworm.com/index.php?rid=5607377&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22241859%26dopt%3DAbstract Authors: Abdrakhmanova GR, Kang M, Damaj MI, Akbarali HI Abstract Recently we reported that nicotine in vitro at low 1 µM concentration suppresses hyperexcitability of colonic dorsal root ganglia (DRG) (L1-L2) neurons in the dextran sodium sulfate (DSS)-induced mouse model of acute colonic inflammation (1). Here we show that multiple action potential firing in colonic DRG neurons persisted at least for 3 weeks post DSS administration while the inflammatory signs were diminished. Similar to that in DSS-induced acute colitis, bath-applied nicotine (1 µM) gradually reduced regenerative multiple-spike action potentials in colonic DRG neurons to a single action potential in 3 weeks post-DSS neurons. Nicotine (1 µM) shifted the activation curve for tetrodotoxin (TTX)-resistant sodium ... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5607377 Thu, 12 Jan 2012 05:00:00 +0100 5607377 http://www.medworm.com/index.php?rid=5607376&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22241860%26dopt%3DAbstract Conclusion: We show that the colonic mucosa associated bacterial microbiome is altered in a subset of alcoholics. The altered microbiota composition is persistent and correlates with endotoxemia in a sub-group of alcoholics. PMID: 22241860 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5607376 Thu, 12 Jan 2012 05:00:00 +0100 5607376 http://www.medworm.com/index.php?rid=5607375&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22241861%26dopt%3DAbstract Authors: Bowie RV, Donatello S, Lyes C, Owens MB, Babina IS, Hudson L, Walsh SV, O'Donoghue DP, Amu S, Barry SP, Fallon PG, Hopkins AM Abstract Intestinal epithelial barrier disruption is a feature of inflammatory bowel disease (IBD), but whether barrier disruption precedes or merely accompanies inflammation remains controversial. Tight junction (TJ) adhesion complexes control epithelial barrier integrity. Since some TJ proteins reside in cholesterol-enriched regions of the cell membrane termed lipid rafts, we sought to elucidate the relationship between rafts and intestinal epithelial barrier function. Lipid rafts were isolated from Caco-2 intestinal epithelial cells primed with the pro-inflammatory cytokine Interferon-γ (IFN-γ), or treated with methyl-β-cyclodextrin as a posit... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5607375 Thu, 12 Jan 2012 05:00:00 +0100 5607375 http://www.medworm.com/index.php?rid=5607374&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22241862%26dopt%3DAbstract Authors: Sarkar S, Kantara C, Singh P Abstract Cell-surface associated AnnexinA2 (CS-ANXA2) is a non-conventional 'receptor' for progastrin; expression levels of both are elevated in colon cancers, and down-regulation of either reduces tumorigenic potential of cells. We recently reported internalization of progastrin in target cells. In here, mechanisms mediating internalization of progastrin were examined. Initially we confirmed that Cell-surface ANXA2 mediates binding and internalization of progastrin in intestinal cells. Progastrin, covalently linked to Sepharose-Beads, failed to activate p38MAPK/ERKs, suggesting internalization of progastrin was required for eliciting biological effects; importantly AnnexinA2 expression, and availability of CS-ANXA2, was required for internaliz... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5607374 Thu, 12 Jan 2012 05:00:00 +0100 5607374 http://www.medworm.com/index.php?rid=5607373&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22241863%26dopt%3DAbstract In conclusion, Ca(2+)-dependent mitochondrial ROS formation is the molecular signal culminating in onset of the MPT after reoxygenation of anoxic hepatocytes, leading to cell death. PMID: 22241863 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5607373 Thu, 12 Jan 2012 05:00:00 +0100 5607373 http://www.medworm.com/index.php?rid=5553011&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22207575%26dopt%3DAbstract Authors: Kohan AB, Wang F, Li X, Bradshaw S, Yang Q, Caldwell-Lawson J, Bullock TM, Tso P Abstract Dietary fat is an important mediator of atherosclerosis and obesity. Despite its importance in mediating metabolic disease, there is still much unknown about dietary fat absorption in the intestine, and especially the detailed biological roles of intestinal apolipoproteins involved in that process. We were specifically interested in determining the physiological role of the intestinal apolipoprotein A-IV (A-IV) using A-IV knockout (KO) mice. A-IV is stimulated by fat absorption in the intestine, and is secreted on nascent chylomicrons into intestinal lymph. We found that A-IV KO mice had reduced plasma triglyceride (TG) and cholesterol levels, and that this hypolipidemia persisted on ... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5553011 Thu, 29 Dec 2011 05:00:00 +0100 5553011 http://www.medworm.com/index.php?rid=5553010&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22207576%26dopt%3DAbstract Authors: Kaji I, Yasuoka Y, Karaki SI, Kuwahara A Abstract In gastrointestinal (GI) physiology, anion and fluid secretion is an important function for host defense, and is induced by changes in the luminal environment. The transient receptor potential A1 (TRPA1) channel is considered to be a chemosensor in several sensory tissues. Although the function of TRPA1 has been studied in GI motility, its contribution to the transepithelial ion transport system has rarely been discussed. In the present study, we investigated the secretory effect of the potential TRPA1 agonist allyl isothiocyanate (AITC) in rat and human colon using an Ussing chamber. The mucosal application of AITC (10(-6)-10(-3) M) induced Cl(-) and HCO(3)(-) secretion in a concentration-dependent manner, while the serosa... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5553010 Thu, 29 Dec 2011 05:00:00 +0100 5553010 http://www.medworm.com/index.php?rid=5553009&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22207577%26dopt%3DAbstract METABOLISM OF 13C5-HYDROXYPROLINE IN VITRO AND IN VIVO: IMPLICATIONS FOR PRIMARY HYPEROXALURIA. Am J Physiol Gastrointest Liver Physiol. 2011 Dec 29; Authors: Jiang J, Johnson LC, Knight J, Callahan MF, Riedel TJ, Holmes RP, Lowther WT Abstract Hydroxyproline (Hyp) metabolism is a key source of glyoxylate production in the body and may be a major contributor to excessive oxalate production in the Primary Hyperoxalurias where glyoxylate metabolism is impaired. Important gaps that exist in our knowledge include identification of the tissues with the capacity to degrade Hyp and the development of model systems to study this metabolism and how to suppress it. The expression of mRNA for enzymes in the pathway was examined in 15 different human tissues. Expression of the complete... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5553009 Thu, 29 Dec 2011 05:00:00 +0100 5553009 http://www.medworm.com/index.php?rid=5553008&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22207578%26dopt%3DAbstract Authors: Liu Y, Fatheree NY, Mangalat N, Rhoads JM Abstract Necrotizing enterocolitis (NEC) is the leading gastrointestinal cause of mortality and morbidity in the premature infant. Premature infants have a delay in intestinal colonization by commensal bacteria and colonization with potentially pathogenic organisms. Lactobacillus reuteri (LR) is a probiotic that inhibits enteric infections, modulates the immune system, and may be beneficial to prevent NEC. In previous studies, LR strains DSM 17938 and ATCC PTA 4659 differentially modulated inflammation in vitro; however, the strains had equivalent anti-inflammatory responses in LPS feeding--induced ileitis in neonatal rats in vivo. The impact of these two strains in the prevention of NEC has not been previously investigated. NEC wa... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5553008 Thu, 29 Dec 2011 05:00:00 +0100 5553008 http://www.medworm.com/index.php?rid=5553007&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22207579%26dopt%3DAbstract We examined the hypothesis that myosin Va, by transporting purinergic vesicles to the varicosity membrane for exocytosis, plays a key role in purinergic vesicular neurotransmission. Studies were performed in WT and myosin Va-deficient DBA mice. Intracellular microelectrode recordings were made in mouse antral muscle strips. Purinergic inhibitory junction potential (pIJP) was recorded under NANC conditions after masking the nitrergic junction potentials. DBA mice showed reduced pIJP but normal hyperpolarizing response to P2Y1 receptor agonist MRS2365. In order to investigate the mechanism of reduced purinergic transmission in DBA mice, studies were performed in isolated varicosities obtained from homogenates of whole gut tissues by ultracentrifugation and sucrose cushion purification. Purin... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5553007 Thu, 29 Dec 2011 05:00:00 +0100 5553007 http://www.medworm.com/index.php?rid=5553006&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22207580%26dopt%3DAbstract Conclusions: This is the first demonstration of a reentrant arrhythmia in the small intestine of control and diabetic rats. Calculations of the size of the circuit indicate that they are small enough to fit inside the intestinal wall. Extrapolation based on measured velocities and rates indicate that reentrant arrhythmias are also possible in the distal small intestine of larger animals including humans. PMID: 22207580 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5553006 Thu, 29 Dec 2011 05:00:00 +0100 5553006 http://www.medworm.com/index.php?rid=5553005&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22207581%26dopt%3DAbstract Authors: Rajavelu P, Rayapudi M, Moffitt M, Mishra A, Mishra A Abstract Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disorder driven by food hypersensitivity; however, the specific foods and mechanisms involved are unclear. In EoE patients, we have found that hypersensitivities to corn and peanuts are the most common. Accordingly, we sensitized and exposed mice either intranasally or intragastrically with corn or peanut extract or saline. Esophageal eosinophilia, the genes of eosinophil-directed cytokines, and allergen-induced antibodies were examined in mice challenged with corn or peanut extract or saline. A high number of esophageal lamina propria eosinophils as well as eosinophilic microabscesses, intraepithelial eosinophils, extracellular eosinophilc gr... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5553005 Thu, 29 Dec 2011 05:00:00 +0100 5553005 http://www.medworm.com/index.php?rid=5539400&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F11%252F20%252008.24%2522%255BMHDA%255D%253A%25222011%252F12%252F25%252009.00%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F11%252F20%252008.24%2522%255BEDAT%255D%29%29 65 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/12/25PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5539400 Sun, 25 Dec 2011 14:00:06 +0100 5539400 http://www.medworm.com/index.php?rid=5428395&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22094600%26dopt%3DAbstract Authors: Novak EM, Keller BO, Innis SM Abstract The n-3 fatty acids contribute to regulation of hepatic fatty acid oxidation and synthesis in adults, and accumulate in fetal and infant liver in variable amounts depending on the maternal diet fat composition. Using 2D gel proteomics and MALDI-TOF mass spectrometry, we recently identified altered abundance of proteins associated with glucose and amino acid metabolism in neonatal rat liver with increased n-3 fatty acids. Here, we extend studies on n-3 fatty acids in hepatic metabolic development to targeted gene and metabolite analyses, and map the results into metabolic pathways to consider the role of n-3 fatty acids in glucose, fatty acid and amino metabolism. Feeding rats 1.5% compared to <0.1% energy 18:3n-3 during gestation l... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5428395 Thu, 17 Nov 2011 05:00:00 +0100 5428395 http://www.medworm.com/index.php?rid=5428394&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22094601%26dopt%3DAbstract MITOCHONDRIAL UNCOUPLING PROTEIN-2 DEFICIENCY PROTECTS STEATOTIC MOUSE HEPATOCYTES FROM HYPOXIA/REOXYGENATION. Am J Physiol Gastrointest Liver Physiol. 2011 Nov 17; Authors: Evans ZP, Palanisamy AP, Sutter AG, Ellett JD, Ramshesh VK, Attaway H, Schmidt MG, Schnellmann RG, Chavin KD Abstract Steatotic livers are sensitive to ischemic events and associated ATP depletion. Hepatocellular necrosis following these events may result from mitochondrial uncoupling protein-2 (UCP2) expression. To test this hypothesis, we developed a model of in vitro steatosis using primary hepatocytes from wild-type and UCP2 knockout mice, and subjected them to hypoxia/reoxygenation (H/R). Using cultured hepatocytes treated with emulsified fatty acids for 24 hr, generating a steatotic phenotype (i.e... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5428394 Thu, 17 Nov 2011 05:00:00 +0100 5428394 http://www.medworm.com/index.php?rid=5428393&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22094602%26dopt%3DAbstract Authors: Olsen AK, Boyd M, Danielsen ET, Troelsen JT Abstract Upon developmental or environmental cues, the composition of transcription factors in a transcriptional regulatory network is deeply implicated in controlling the signature of the gene expression and thereby specifies the cell- or tissue-type. Novel methods including ChIP-chip and ChIP-Seq have been applied to analyse known transcription factors and their interacting regulatory DNA elements in the intestine. The intestine is an example of a dynamic tissue where stem cells in the crypt proliferate and undergo a differentiation process towards the villus. During this differentiation process, specific regulatory networks of transcription factors are activated to target specific genes, which determine the intestinal cell fat... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5428393 Thu, 17 Nov 2011 05:00:00 +0100 5428393 http://www.medworm.com/index.php?rid=5428392&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22094603%26dopt%3DAbstract Authors: Jain AK, Stoll B, Burrin DG, Holst JJ, Moore DD Abstract Total parenteral nutrition (TPN) is essential for patients with impaired gut function, but leads to parenteral nutrition associated liver disease (PNALD). TPN disrupts the normal enterohepatic circulation of bile acids and we hypothesized that it would decrease intestinal expression of the newly described metabolic hormone fibroblast growth factor-19 (FGF19) and also glucagon-like peptides 1 and 2 (GLP-1 and GLP-2). We tested the effects of restoring bile acids by treating a neonatal piglet PNALD model with chenodeoxycholic acid (CDCA). Neonatal pigs received enteral feeding (EN), TPN or TPN + CDCA for 14 days, and responses were assessed by serum markers, histology and levels of of key regulatory peptides. Cholestas... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5428392 Thu, 17 Nov 2011 05:00:00 +0100 5428392 http://www.medworm.com/index.php?rid=5383629&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F10%252F15%252016.54%2522%255BMHDA%255D%253A%25222011%252F11%252F08%252006.40%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F10%252F15%252016.54%2522%255BEDAT%255D%29%29 35 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/11/08PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5383629 Tue, 08 Nov 2011 11:40:04 +0100 5383629 http://www.medworm.com/index.php?rid=5317619&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F10%252F05%252012.59%2522%255BMHDA%255D%253A%25222011%252F10%252F15%252016.54%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F10%252F05%252012.59%2522%255BEDAT%255D%29%29 26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/10/15PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5317619 Sat, 15 Oct 2011 20:54:56 +0100 5317619 http://www.medworm.com/index.php?rid=5268742&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F09%252F20%252015.07%2522%255BMHDA%255D%253A%25222011%252F09%252F30%252010.00%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F09%252F20%252015.07%2522%255BEDAT%255D%29%29 20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/09/30PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5268742 Fri, 30 Sep 2011 14:00:12 +0100 5268742 http://www.medworm.com/index.php?rid=5221763&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F09%252F06%252013.24%2522%255BMHDA%255D%253A%25222011%252F09%252F15%252022.43%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F09%252F06%252013.24%2522%255BEDAT%255D%29%29 29 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/09/15PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5221763 Fri, 16 Sep 2011 02:43:54 +0100 5221763 http://www.medworm.com/index.php?rid=5196044&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885684%26dopt%3DAbstract Conclusion: Our study shows tight coupling between axial stretch on the LES and relaxation of the LES, which suggests a cause and effect relationship between the two. We propose that the vagus nerve fibers that cause LMC induce LES relaxation through the stretch sensitive activation of inhibitory motor neurons. PMID: 21885684 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5196044 Wed, 31 Aug 2011 23:00:00 +0100 5196044 http://www.medworm.com/index.php?rid=5196043&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885685%26dopt%3DAbstract Conclusions: These findings indicate that LES CSM is abnormal in W/W(v) mutant mice. Thus, some physiological functions attributed to ICC-IM based on experiments in smooth muscle of ICC deficient mice may need to be reconsidered. PMID: 21885685 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5196043 Wed, 31 Aug 2011 23:00:00 +0100 5196043 http://www.medworm.com/index.php?rid=5196042&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21885686%26dopt%3DAbstract This study examined the effects of estrogen on NASH in ovariectomized (OVX) mice fed a high fat and high cholesterol (HFHC) diet. To investigate the effects of estrogen deficiency, OVX mice and sham-operated (SO) mice were fed normal chow or HFHC diet for 6 weeks. Next, to investigate the effects of exogenous estrogen replenishment, OVX mice fed with HFHC diet were treated with implanted hormone release pellets [containing 17β-estradiol or placebo vehicle] for 6 weeks. OVX mice on the HFHC diet showed enhanced liver injury with increased liver macrophage infiltration and elevated serum cholesterol levels compared with SO-HFHC mice. Hepatocyte monocyte chemoattractant protein-1 (MCP1) protein expression in OVX- HFHC mice was also enhanced compared with SO-HFHC mice. In addition, the expres... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5196042 Wed, 31 Aug 2011 23:00:00 +0100 5196042 http://www.medworm.com/index.php?rid=5160486&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868631%26dopt%3DAbstract Authors: D'Mello C, Swain MG Abstract It is becoming increasingly evident that peripheral organ centered inflammatory diseases, including chronic inflammatory liver diseases, are associated with changes in central neural transmission that result in alterations in behavior. These behavioral changes include sickness behaviors such as fatigue, cognitive dysfunction, mood disorders, and sleep disturbances. While such behaviors have a significant impact on patient quality of life, the changes within the brain and the communication pathways between the liver and the brain that give rise to changes in central neural activity are not fully understood. Traditionally, neural and humoral communication pathways have been described, with the three cytokines TNFα, IL-1β and IL-6 receiving the ... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5160486 Wed, 24 Aug 2011 23:00:00 +0100 5160486 http://www.medworm.com/index.php?rid=5160485&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868632%26dopt%3DAbstract Authors: Subramanya SB, Subramanian VS, Sekar VT, Said HM Abstract Thiamin is important for normal function of pancreatic acinar cells, but little is known about its mechanism of uptake and about the effect of chronic alcohol use on the process. We addressed these issues using freshly isolated rat primary and rat-derived cultured AR42J pancreatic acinar cells as models. Results showed that thiamin uptake by both primary and cultured AR42J pancreatic acinar cells to be via a specific carrier-mediated mechanism, and that both of the thiamin transporter -1 and 2 (THTR-1 and THTR-2) are expressed in these cells. Chronic alcohol feeding of rats was found to lead to a significant inhibition of carrier-mediated thiamin uptake by pancreatic acinar cells, and was associated with a significa... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5160485 Wed, 24 Aug 2011 23:00:00 +0100 5160485 http://www.medworm.com/index.php?rid=5160484&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868633%26dopt%3DAbstract Authors: Basalingappa KM, Rajendran VM, Wonderlin WF Abstract Kcnn4 channels in the apical and basolateral membranes of epithelial cells play important roles in agonist-induced fluid secretion in intestine and colon. Basolateral Kcnn4 channels have been well characterized in situ using patch-clamp methods, but the investigation of Kcnn4 channels in apical membranes in situ has been hampered by a layer of mucus that prevents seal formation. In the present study we used patch-clamp methods to characterize Kcnn4 channels in the apical membrane of IEC-18 cells, a cell line derived from rat small intestine. A monolayer of IEC-18 cells grown on a permeable support is devoid of mucus, and tight junctions enable selective access to the apical membrane. In inside-out patches, Ca(2+)-depende... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5160484 Wed, 24 Aug 2011 23:00:00 +0100 5160484 http://www.medworm.com/index.php?rid=5160483&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868634%26dopt%3DAbstract Authors: Meng F, Alpini G Abstract Confocal laser endomicroscopy (CLE) is a novel imaging modality providing in vivo histology and allowing capture of very high-resolution images of human and animal liver. The manuscript from Goetz and colleagues in this issue of American Journal of Physiology GI and Liver, used CLE to continuously follow distinct morphological, functional and molecular features of apoptosis in intact liver in vivo and at high resolution. This new technology allowed the authors to make several important observations whilst highlighting the enormous promise of this technology for future in vivo studies of hepatic apoptosis and its pharmacological manipulation in animals and humans. PMID: 21868634 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi.... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5160483 Wed, 24 Aug 2011 23:00:00 +0100 5160483 http://www.medworm.com/index.php?rid=5160482&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868635%26dopt%3DAbstract Conclusions: The results suggest that bisacodyl may decrease the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect. This study also showed that direct activation of colon macrophages by bisacodyl increases the secretion of PGE(2), which acts as a paracrine factor and decreases AQP3 expression in colon mucosal epithelial cells. PMID: 21868635 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5160482 Wed, 24 Aug 2011 23:00:00 +0100 5160482 http://www.medworm.com/index.php?rid=5160481&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21868636%26dopt%3DAbstract Authors: Purwanti N, Karabasil MR, Matsuo S, Chen G, Javkhlan P, Azlina A, Hasegawa T, Yao C, Akamatsu T, Hosoi K Abstract To examine the very initial step which takes place immediately after tissue injury and is linked to tissue regeneration, we employed the submandibular gland (SMG) which was injured by ligation of its main excretory duct. Ligation of the main excretory duct (MED) of the SMG in mice induced the expression of Sca-1, a protein marker of hematopoietic stem cells. In the normal gland, a low level of Sca-1 was expressed, which was localized predominantly in the excretory duct cells. At 1 day after ligation, Sca-1 expression increased prominently in almost all of cells in the duct system, but not in the acinar cells. The level of Sca-1 mRNA had begun to increase at 6 h... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5160481 Wed, 24 Aug 2011 23:00:00 +0100 5160481 http://www.medworm.com/index.php?rid=5143418&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F08%252F11%252010.15%2522%255BMHDA%255D%253A%25222011%252F08%252F20%252009.18%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F08%252F11%252010.15%2522%255BEDAT%255D%29%29 35 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/08/20PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5143418 Sat, 20 Aug 2011 13:18:03 +0100 5143418 http://www.medworm.com/index.php?rid=5020318&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F06%252F28%252004.15%2522%255BMHDA%255D%253A%25222011%252F07%252F13%252011.15%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F06%252F28%252004.15%2522%255BEDAT%255D%29%29 62 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/07/13PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=5020318 Wed, 13 Jul 2011 15:15:02 +0100 5020318 http://www.medworm.com/index.php?rid=4924702&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21659618%26dopt%3DAbstract We examined the effects of aspirin-triggered lipoxin (ATL), a stable analog of lipoxin A(4), on the antimicrobial responses of human peripheral blood mononuclear cell-derived macrophages and the monocytic THP-1 cell line. Additionally, we assessed the expression and localization of the lipoxin receptor, formyl peptide receptor 2 (FPR2), in colonic mucosal biopsies from patients with Crohn`s disease to determine if the capacity for lipoxin signalling is altered in inflammatory bowel disease (IBD). We found that THP-1 cells treated with ATL (100nM) displayed increased phagocytosis of inert fluorescent beads and Escherichia coli in a scavenger receptor- and PI-3K-dependent, opsonisation-independent manner. This ATL-induced increase in phagocytosis was also observed in primary human macrophage... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4924702 Wed, 08 Jun 2011 23:00:00 +0100 4924702 http://www.medworm.com/index.php?rid=4924701&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21659619%26dopt%3DAbstract Authors: Hodges CA, Grady BR, Mishra K, Cotton CU, Drumm ML Maldigestion, due to exocrine pancreatic insufficiency, leads to intestinal malabsorption and consequent malnutrition, a mechanism proposed to cause growth retardation associated with cystic fibrosis. However, while enzyme replacement therapy combined with increased caloric intake improves weight gain, the effect on stature is not significant, suggesting that growth retardation has a more complex etiology. Mouse models of CF support this, as these animals do not experience exocrine pancreatic insufficiency, yet are growth impaired. Cftr absence from the intestinal epithelium has been suggested as a primary source of growth retardation in CF mice, a concept we directly tested by generating mouse models with Cftr selectively ina... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4924701 Wed, 08 Jun 2011 23:00:00 +0100 4924701 http://www.medworm.com/index.php?rid=4924700&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21659620%26dopt%3DAbstract Authors: Patsenker E, Stickel F Integrins and other cell adhesion molecules regulate numerous physiological and pathological mechanisms by mediating the interaction between cells and their extracellular environment. While the significance of integrins in the evolution and progression of certain cancers is well-recognized, their involvement in non-malignant processes, such as organ fibrosis or inflammation is only beginning to emerge. However, accumulating evidence points to an instrumental role of integrin-mediated signaling in a variety of chronic and acute non-cancerous diseases, particularly of the liver. Liver fibrosis constitutes the uniform response of liver tissue to chronic injury and develops as a consequence of accelerated matrix generation and impaired degradation, partly tr... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4924700 Wed, 08 Jun 2011 23:00:00 +0100 4924700 http://www.medworm.com/index.php?rid=4924699&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21659621%26dopt%3DAbstract Authors: Kastanis GJ, Hernandez-Nazara Z, Nieto N, Rincon-Sanchez AR, Popratiloff A, Dominguez-Rosales JA, Lechuga CG, Rojkind M Hepatic stellate cells are embedded in the loose connective tissue matrix within the Space of Disse. This extracellular matrix contains several basement membrane components including laminin but its composition changes during liver injury due to the production of extracellular matrix components found in scar tissue. These changes in extracellular matrix composition and in cell-extracellular matrix interactions may play a key role in hepatic stellate cell transdifferentiation. In this communication we used early passages of mouse hepatic stellate cells (activated HSC/myofibroblasts) to study the PDGF-BB-dependent expression and regulation of β-dystroglycan an... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4924699 Wed, 08 Jun 2011 23:00:00 +0100 4924699 http://www.medworm.com/index.php?rid=4824803&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21566012%26dopt%3DAbstract TNF TRANSACTIVATION OF EGFR STIMULATES CYTOPROTECTIVE COX-2 EXPRESSION IN GASTROINTESTINAL EPITHELIAL CELLS. Am J Physiol Gastrointest Liver Physiol. 2011 May 12; Authors: Hobbs SS, Goettel JA, Liang D, Yan F, Edelblum KL, Frey MR, Mullane MT, Polk DB Tumor necrosis factor (TNF) and epidermal growth factor (EGF) are well known stimuli of cyclooxygenase-2 (COX-2) expression, and TNF stimulates transactivation of EGF receptor (EGFR) signaling to promote survival in colon epithelial cells. We hypothesized that COX-2 induction and cell survival signaling downstream of TNF are mediated by EGFR transactivation. TNF treatment was more cytotoxic to COX-2(-/-) mouse colon epithelial (MCE) cells than to wild-type young adult mouse colon (YAMC) epithelial cells or COX-1(-/-) cells. TNF al... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4824803 Wed, 11 May 2011 23:00:00 +0100 4824803 http://www.medworm.com/index.php?rid=4824802&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21566013%26dopt%3DAbstract PHARYNGEAL AIRWAY PROTECTIVE REFLEXES ARE TRIGGERED BEFORE THE MAXIMUM VOLUME OF FULID THAT THE HYPOPHARYNX CAN SAFELY HOLD IS EXCEEDED. Am J Physiol Gastrointest Liver Physiol. 2011 May 12; Authors: Dua KS, Surapaneni SN, Kuribayashi S, Hafeezullah M, Shaker R Aerodigestive reflexes triggered by pharyngeal stimulation can protect the airways by clearing fluid from the pharynx. Objective of this study was to determine the relationship between the maximum capacity of fluid that can safely dwell in the hypopharynx (Hypopharyngeal Safe Volume; HPSV) before spilling into the larynx and the threshold volumes required to trigger Pharyngoglottal Closure reflex; PGCR, Pharyngo-UES Contractile reflex, PUCR, and Reflexive Pharyngeal Swallow; RPS. Twenty-five healthy volunteers (mean age ... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4824802 Wed, 11 May 2011 23:00:00 +0100 4824802 http://www.medworm.com/index.php?rid=4824801&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21566014%26dopt%3DAbstract Authors: Bondzio A, Gabler C, Badewien-Rentzsch B, Schulze P, Martens H, Einspanier R Ruminal epithelium adapts to dietary change with well coordinated alterations in metabolism, proliferation, and permeability. In order to further understand the molecular events controlling diet effects, the aim of this study was to evaluate protein expression patterns of ruminal epithelium in response to various feeding regimes. Sheep were fed with a concentrate-supplemented diet for up to six weeks. The control group received hay only. Proteome analysis with differential in gel electrophoresis (DIGE) technology revealed that, after 2 days, 60 proteins were significantly modulated in ruminal epithelium in a comparison between hay-fed and concentrate-fed sheep (P<0.05). 40 proteins were up-regulate... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4824801 Wed, 11 May 2011 23:00:00 +0100 4824801 http://www.medworm.com/index.php?rid=4824800&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21566015%26dopt%3DAbstract Conclusion: In human IAS SMCs RhoA/ROCK in comparison with PKC are constitutively active, and contractility by PDBu is associated with RhoA/ROCK activation. The relative contribution of RhoA/ROCK vs. PKC in the pathophysiology and potential therapy for the IAS dysfunction remains to be determined. PMID: 21566015 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4824800 Wed, 11 May 2011 23:00:00 +0100 4824800 http://www.medworm.com/index.php?rid=4824799&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21566016%26dopt%3DAbstract In conclusion, these findings suggest that basally-activated NSCC contribute to the RMP in human and monkey colonic SMC and therefore may play an important role in determining basal excitability of colonic smooth muscle. PMID: 21566016 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4824799 Wed, 11 May 2011 23:00:00 +0100 4824799 http://www.medworm.com/index.php?rid=4771227&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F04%252F17%252007.30%2522%255BMHDA%255D%253A%25222011%252F05%252F02%252002.00%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F04%252F17%252007.30%2522%255BEDAT%255D%29%29 24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/05/02PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4771227 Mon, 02 May 2011 06:00:03 +0100 4771227 http://www.medworm.com/index.php?rid=4722178&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21493730%26dopt%3DAbstract Authors: Ueda T, Shikano M, Kamiya T, Joh T, Ugawa S The esophageal epithelium has sensory properties that enable it to sustain normal barrier function. Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+)-permeable channel that is activated by extracellular hypotonicity, polyunsaturated fatty acids, phorbol esters and elevated temperature. We found that TRPV4 is expressed in both human esophageal tissue and in HET-1A cells, a human esophageal epithelial cell line. Specific activation of TRPV4 by the phorbol ester 4-α-phorbol 12,13-didecanoate (4α-PDD) increased intracellular Ca(2+) in a subset of HET-1A cells. Elevated temperature strongly potentiated this effect at low concentrations of 4α-PDD, and all of the responses were inhibited by the TRPV antagonist ruthenium red. T... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4722178 Wed, 13 Apr 2011 23:00:00 +0100 4722178 http://www.medworm.com/index.php?rid=4722177&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21493731%26dopt%3DAbstract GLUTATHIONE PEROXIDASE-3 PRODUCED BY THE KIDNEY BINDS TO A POPULATION OF BASEMENT MEMBRANES IN THE GASTROINTESTINAL TRACT AND IN OTHER TISSUES. Am J Physiol Gastrointest Liver Physiol. 2011 Apr 14; Authors: Burk RF, Olson GE, Winfrey VP, Hill KE, Yin D Glutathione peroxidase-3 (Gpx3), the extracellular glutathione peroxidase synthesized largely in the kidney, binds to basement membranes of renal cortical epithelial cells. The present study assessed extra-renal expression of Gpx3 using RT-PCR and presence of Gpx3 protein using immunocytochemistry. Gpx3 expression was higher in kidney and epididymis than in other tissues. Gpx3 bound to basement membranes of epithelial cells in the gastrointestinal tract, the efferent ducts connecting the seminiferous tubules with the epididymis, ... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4722177 Wed, 13 Apr 2011 23:00:00 +0100 4722177 http://www.medworm.com/index.php?rid=4722176&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21493732%26dopt%3DAbstract EFFECT OF NIFEDIPINE ON ANORECTAL SENSORIMOTOR FUNCTIONS IN HEALTH AND FECAL INCONTINENCE. Am J Physiol Gastrointest Liver Physiol. 2011 Apr 14; Authors: Bharucha AE, Edge J, Zinsmeister AR The mechanisms of increased rectal stiffness in women with fecal incontinence (FI) and rectal urgency are not understood. Our hypothesis was that distention-induced activation of mechanosensitive L-type calcium channels in smooth muscle contributes to increased rectal stiffness in FI. Anal pressures, rectal distensibility (compliance, capacity, and contractile response to sinusoidal oscillation), and rectal sensation were assessed before and after oral nifedipine (30 + 10mg) or placebo in 16 women with FI and 16 asymptomatic women. At baseline, FI patients had a lower anal pressure increment... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4722176 Wed, 13 Apr 2011 23:00:00 +0100 4722176 http://www.medworm.com/index.php?rid=4722182&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21474649%26dopt%3DAbstract Authors: Flannigan KL, McCoy KD, Wallace JL Hydrogen sulfide (H(2)S) is an important modulator of many aspects of digestive function, both in health and disease. Colonic tissue H(2)S synthesis increases markedly during injury and inflammation, and appears to contribute to resolution. Some of the bacteria residing the colon can also produce H(2)S. The extent to which bacterial H(2)S synthesis contributes to what is measured as colonic H(2)S synthesis is not clear. Using conventional and germ-free mice, we have delineated the eukaryotic versus prokaryotic contributions to colonic H(2)S synthesis, both in healthy and colitic mice. Colonic tissue H(2)S production is entirely dependent upon the presence of the cofactor pyrixodal-5'-phosphate (vitamin B6), while bacterial H(2)S synthesis app... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4722182 Wed, 06 Apr 2011 23:00:00 +0100 4722182 http://www.medworm.com/index.php?rid=4722181&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21474650%26dopt%3DAbstract Authors: Samak G, Aggarwal S, Rao RK The role of MAP kinases in the mechanism of EGF-mediated prevention of acetaldehyde-induced tight junction disruption was evaluated in Caco-2 cell monolayers. Pretreatment of cell monolayers with EGF attenuated acetaldehyde-induced decrease in resistance, increase in inulin permeability and redistribution of occludin, ZO-1, E-cadherin and β-catenin from the intercellular junctions. EGF rapidly increased the levels of phospho-ERK1/2, phospho-p38MAPK and phospho-JNK1. Pretreatment of cell monolayers with U0126 (inhibitor of ERK activation), but not SB202190 and SP600125 (p38MAPK and JNK inhibitors), significantly attenuated EGF-mediated prevention of acetaldehyde-induced changes in resistance, inulin permeability and redistribution of occludin and ZO... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4722181 Wed, 06 Apr 2011 23:00:00 +0100 4722181 http://www.medworm.com/index.php?rid=4722180&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21474651%26dopt%3DAbstract Conclusions: Our results demonstrate that human esophageal epithelial cells can sense endogenous danger signals, in part through TLR3 signaling. This supports the concept that epithelial injury plays an inciting role in the pathogenesis of reflux-induced esophagitis, providing important insights into the mechanisms by which epithelial injury leads to inflammation. PMID: 21474651 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4722180 Wed, 06 Apr 2011 23:00:00 +0100 4722180 http://www.medworm.com/index.php?rid=4722179&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21474652%26dopt%3DAbstract Authors: Murray JW, Thosani AJ, Wang P, Wolkoff AW Sodium taurocholate co-transporting polypeptide (ntcp) is considered to be a major determinant of bile acid uptake into hepatocytes. However the regulation of ntcp and the degree that it participates in the accumulation of specific substrates is not well understood. We utilized fluorescent bile acid derivatives and direct quantitation of fluorescent microscopy images to examine the regulation of ntcp and its role in the cell-to-cell variability of fluorescent bile acid accumulation. Primary-cultured rat hepatocytes rapidly accumulated the fluorescent bile acids, chenodeoxycholylglycylamidofluorescein (CDCGamF), 7-beta-NBD 3-alpha hydroxy 5-beta cholan-24-oic acid (NBD-CA), and cholyl-glycylamido-fluorescein (CGamF). However in stably-t... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4722179 Wed, 06 Apr 2011 23:00:00 +0100 4722179 http://www.medworm.com/index.php?rid=4669262&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F03%252F19%252000.45%2522%255BMHDA%255D%253A%25222011%252F04%252F02%252011.45%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F03%252F19%252000.45%2522%255BEDAT%255D%29%29 16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/04/02PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4669262 Sat, 02 Apr 2011 15:45:12 +0100 4669262 http://www.medworm.com/index.php?rid=4610605&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F03%252F04%252019.30%2522%255BMHDA%255D%253A%25222011%252F03%252F19%252000.45%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F03%252F04%252019.30%2522%255BEDAT%255D%29%29 28 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/03/19PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4610605 Sat, 19 Mar 2011 04:45:02 +0100 4610605 http://www.medworm.com/index.php?rid=4548085&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F02%252F18%252017.15%2522%255BMHDA%255D%253A%25222011%252F03%252F04%252019.30%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F02%252F18%252017.15%2522%255BEDAT%255D%29%29 16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/03/04PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4548085 Sat, 05 Mar 2011 00:30:30 +0100 4548085 http://www.medworm.com/index.php?rid=4493632&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F02%252F01%252020.30%2522%255BMHDA%255D%253A%25222011%252F02%252F18%252017.15%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F02%252F01%252020.30%2522%255BEDAT%255D%29%29 32 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/02/18PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4493632 Fri, 18 Feb 2011 22:15:02 +0100 4493632 http://www.medworm.com/index.php?rid=4424011&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222011%252F01%252F18%252018.30%2522%255BMHDA%255D%253A%25222011%252F02%252F01%252020.30%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F01%252F18%252018.30%2522%255BEDAT%255D%29%29 26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/02/01PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4424011 Wed, 02 Feb 2011 01:30:02 +0100 4424011 http://www.medworm.com/index.php?rid=4360777&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F12%252F15%252015.20%2522%255BMHDA%255D%253A%25222011%252F01%252F18%252018.30%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F12%252F15%252015.20%2522%255BEDAT%255D%29%29 23 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2011/01/18PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4360777 Tue, 18 Jan 2011 23:30:03 +0100 4360777 http://www.medworm.com/index.php?rid=4229400&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21127258%26dopt%3DAbstract Authors: Yao Y, Lu S, Huang Y, Beeman-Black CC, Lu R, Pan X, Hussain MM, Black DD Apolipoprotein (apo) A-IV overexpression enhances chylomicron (CM) assembly and secretion in newborn swine intestinal epithelial cells by producing larger particles (J Biol Chem 281:3473-3483, 2006). To determine the impact of apo A-IV on microsomal triglyceride transfer protein (MTTP), IPEC-1 cell lines containing a tetracycline-regulatable expression system were used to overexpress native swine apo A-IV and "pig-like" human apo A-IV, a mutant human apo A-IV with deletion of the EQQQ-rich C-terminus, previously shown to up-regulate basolateral triglyceride (TG) secretion 5-fold and 25-fold, respectively. Cells were incubated 24 hrs with and without doxycycline and oleic acid (OA, 0.8 mM). Overexpression ... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4229400 Thu, 02 Dec 2010 00:00:00 +0100 4229400 http://www.medworm.com/index.php?rid=4229390&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21127259%26dopt%3DAbstract Authors: Goldman A, Chen HD, Roesly HB, Hill KA, Tome ME, Dvorak B, Bernstein H, Dvorak K Barrett's esophagus (BE) is a premalignant condition, where normal squamous epithelium is replaced by intestinal epithelium. BE is associated with an increased risk of developing esophageal adenocarcinoma (EAC). However, the BE cell of origin is not clear. We hypothesize that BE tissue originates from esophageal squamous cells, that can differentiate to columnar cells as a result of repeated exposure exposure to gastric acid and bile acids, two components of refluxate implicated in BE pathology. To test this hypothesis we repeatedly exposed squamous esophageal HET1A cells to 0.2mM bile acid (BA) cocktail at pH 5.5 and developed an HET1AR resistant cell line. These cells are able to survive and pro... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4229390 Thu, 02 Dec 2010 00:00:00 +0100 4229390 http://www.medworm.com/index.php?rid=4205976&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21109589%26dopt%3DAbstract In conclusion, we show that proliferation in colonic epithelia and colon cancer cells, stimulated by EGFR, is mediated via loss of FOXO3 activity, and speculate that FOXO3 may serve as a target in the development of new pharmacological treatments of proliferative diseases. PMID: 21109589 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4205976 Thu, 25 Nov 2010 00:00:00 +0100 4205976 http://www.medworm.com/index.php?rid=4205972&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21109590%26dopt%3DAbstract Authors: Schonhoff CM, Ramasamy U, Anwer MS The sodium-taurocholate (TC) cotransporting polypeptide (NTCP) facilitates bile formation by mediating sinusoidal Na(+)-TC cotransport. During sepsis-induced cholestasis, there is a decrease in NTCP dependent uptake of bile acids and an increase in nitric oxide (NO) levels in hepatocytes. In rat hepatocytes NO inhibits Na(+)-dependent uptake of taurocholate. The aim of this study was to extend these findings to human NTCP and to further investigate the mechanism by which NO inhibits TC uptake. Using a human hepatoma cell line stably expressing NTCP (HuH-NTCP) we performed experiments with the NO donors sodium nitroprusside (SNP) and S-nitrosocysteine (SNOC) and demonstrated that NO inhibits TC uptake in these cells. Kinetic analyses revealed ... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4205972 Thu, 25 Nov 2010 00:00:00 +0100 4205972 http://www.medworm.com/index.php?rid=4205969&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21109591%26dopt%3DAbstract Authors: Li Y, Wu X, Zhou S, Owyang C The paradigm for the control of feeding behavior has changed significantly. Research has shown that leptin, in the presence of CCK, may mediate the control of short-term food intake. This interaction between CCK and leptin occurs at the vagus nerve. In the present study, we aimed to characterize the interaction between CCK and leptin in the vagal primary afferent neurons. Single neuronal discharges of vagal primary afferent neurons innervating the gastrointestinal tract were recorded from rat nodose ganglia. Three groups of nodose ganglia neurons were identified: group 1 responded to CCK-8 but not leptin; group 2 responded to leptin but not CCK-8; group 3 responded to high-dose CCK-8 and leptin. In fact, the neurons in group 3 showed CCK-8 and lept... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4205969 Thu, 25 Nov 2010 00:00:00 +0100 4205969 http://www.medworm.com/index.php?rid=4205968&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21109592%26dopt%3DAbstract Authors: O'Malley D, Liston M, Hyland NP, Dinan TG, Cryan JF Irritable bowel syndrome (IBS) is characterized by episodic bouts of abdominal pain, bloating and altered bowel habit. Accumulating evidence has linked immune activation with IBS including reports of increases in circulating levels of the pro-inflammatory cytokine, interleukin (IL)-6. However, it is unknown whether IL-6 contributes directly to disease manifestation. As enteric nervous activity mediates motility and secretory function, the aims of this study were to determine the effects of IL-6 on submucosal neurons and related gastrointestinal (GI) function. In these studies, we have examined the colons of maternally separated (MS) rats, which exhibit elevated circulating levels of IL-6, in addition to GI dysfunction. To our... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4205968 Thu, 25 Nov 2010 00:00:00 +0100 4205968 http://www.medworm.com/index.php?rid=4205965&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21109593%26dopt%3DAbstract This study demonstrates a correlation between decreasing mucus barrier and increasing clinical symptoms during onset of colitis. Mice lacking colonic mucus (Muc2-/-) were hypersensitive to DSS-induced colitis, while Muc1-/- were protected, probably through the ability to increase the mucus barrier but also by decreased T-cell recruitment to the afflicted site. Further, the ability of bacteria to regulate the thickness of the colonic mucus was demonstrated. PMID: 21109593 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4205965 Thu, 25 Nov 2010 00:00:00 +0100 4205965 http://www.medworm.com/index.php?rid=4205961&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21109594%26dopt%3DAbstract CONCLUSION: Sensori-motor response is primarily induced by the activation and contraction of the puborectalis muscle in response to a sensation of desire to defecate. PMID: 21109594 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4205961 Thu, 25 Nov 2010 00:00:00 +0100 4205961 http://www.medworm.com/index.php?rid=4173679&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F11%252F08%252000.40%2522%255BMHDA%255D%253A%25222010%252F11%252F17%252008.55%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F11%252F08%252000.40%2522%255BEDAT%255D%29%29 26 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/11/17PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4173679 Wed, 17 Nov 2010 13:55:03 +0100 4173679 http://www.medworm.com/index.php?rid=4112549&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F10%252F25%252000.20%2522%255BMHDA%255D%253A%25222010%252F10%252F29%252016.35%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F10%252F25%252000.20%2522%255BEDAT%255D%29%29 45 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/10/29PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4112549 Fri, 29 Oct 2010 20:35:02 +0100 4112549 http://www.medworm.com/index.php?rid=4018537&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20876526%26dopt%3DAbstract Authors: PMID: 20876526 [PubMed - in process] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4018537 Thu, 30 Sep 2010 23:00:00 +0100 4018537 http://www.medworm.com/index.php?rid=4001885&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F09%252F20%252010.12%2522%255BMHDA%255D%253A%25222010%252F09%252F26%252002.24%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F09%252F20%252010.12%2522%255BEDAT%255D%29%29 35 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/09/26PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=4001885 Sun, 26 Sep 2010 06:24:02 +0100 4001885 http://www.medworm.com/index.php?rid=3958994&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F09%252F09%252000.03%2522%255BMHDA%255D%253A%25222010%252F09%252F11%252020.30%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F09%252F09%252000.03%2522%255BEDAT%255D%29%29 21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/09/11PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3958994 Sun, 12 Sep 2010 00:30:02 +0100 3958994 http://www.medworm.com/index.php?rid=3943847&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F08%252F29%252016.57%2522%255BMHDA%255D%253A%25222010%252F09%252F09%252000.03%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F08%252F29%252016.57%2522%255BEDAT%255D%29%29 32 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/09/09PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3943847 Thu, 09 Sep 2010 04:03:02 +0100 3943847 http://www.medworm.com/index.php?rid=3845629&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689055%26dopt%3DAbstract In conclusion, miRNAs and in particular miRNA-21, may play a significant role in modulating proliferation and cell cycle progression genes after PH. miRNA-21 is additionally induced by UDCA in both regenerating rat liver and in vitro, which may represent a new mechanism behind UDCA biological functions. PMID: 20689055 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3845629 Wed, 04 Aug 2010 23:00:00 +0100 3845629 http://www.medworm.com/index.php?rid=3845628&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689056%26dopt%3DAbstract Conclusion: It is suggested that the adaptation mechanism to chronic stress may involve the upregulation of oxytocin expression in the hypothalamus, which in turn attenuates CRF expression. PMID: 20689056 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3845628 Wed, 04 Aug 2010 23:00:00 +0100 3845628 http://www.medworm.com/index.php?rid=3845627&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689057%26dopt%3DAbstract Authors: Scharl M, Rudenko I, McCole DF The Crohn's disease (CD) candidate gene, protein tyrosine phosphatase non-receptor type 2 (PTPN2), has been shown to regulate epidermal growth factor (EGF)-induced phosphatidylinositol 3-kinase (PI3-K) activation in fibroblasts. In intestinal epithelial cells (IECs), EGF-induced EGF receptor (EGFR) activation and recruitment of PI3-K play a key role in regulating many cellular functions including Ca(2+)-dependent Cl(-) secretion. Moreover, EGFR also serves as a conduit for signalling by other non-growth factor receptor ligands such as the proinflammatory cytokine, IFNgamma. Here, we investigated a possible role for PTPN2 in the regulation of EGFR signalling and Ca(2+)-dependent Cl(-) secretion in IECs. PTPN2 knock-down enhanced EGF-induced EGFR t... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3845627 Wed, 04 Aug 2010 23:00:00 +0100 3845627 http://www.medworm.com/index.php?rid=3845626&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689058%26dopt%3DAbstract In conclusion, activated PSCs expressed IL-33 in the nucleus. IL-33 might regulate the PDGF-induced proliferation in PSCs. PMID: 20689058 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3845626 Wed, 04 Aug 2010 23:00:00 +0100 3845626 http://www.medworm.com/index.php?rid=3845625&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689059%26dopt%3DAbstract This study indicates that prolonged intestinal HIF-1 activation is a proximal regulator of I/R-induced gut mucosal injury and gut-induced lung injury. Consequently, these results provide unique information on the initiating events in trauma-hemorrhagic shock-induced ALI and MODS as well as potential therapeutic insights. PMID: 20689059 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3845625 Wed, 04 Aug 2010 23:00:00 +0100 3845625 http://www.medworm.com/index.php?rid=3845624&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689060%26dopt%3DAbstract Authors: Andriamihaja M, Davila AM, Eklou-Lawson M, Petit N, Delpal S, Allek F, Blais A, Delteil C, Tomé D, Blachier F Hyperproteic diets are used in human nutrition to obtain body weight reduction. Although increased protein ingestion results in an increased transfer of proteins from the small to the large intestine, there is little information on the consequences of the use of such diets on the composition of large intestine content and on epithelial cell morphology and metabolism. Rats were fed for 15 days with either a normoproteic (NP, 14% protein) or a hyperproteic isocaloric diet (HP, 53% protein) and absorptive colonocytes were observed by electron microscopy or isolated for enzyme activity studies. The colonic luminal content was recovered for biochemical analysis. Absorbin... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3845624 Wed, 04 Aug 2010 23:00:00 +0100 3845624 http://www.medworm.com/index.php?rid=3845623&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689061%26dopt%3DAbstract Authors: Azlina A, Javkhlan P, Hiroshima Y, Hasegawa T, Yao C, Akamatsu T, Hosoi K Chorda tympani denervation (CTD) of rats was earlier shown to result in loss of submandibular gland (SMG) weight (at only 1 week) and in continued reduction in aquaporin5 (AQP5) protein expression (until 4 weeks), without affecting its mRNA synthesis (Li et al., Am J Physiol Gastrointest Liver Physiol 295: G112-G123, 2008). The present study indicated that in spite of elevation of bax, a pro-apoptosis protein, by CTD, the operation also increased the level of bcl-2, an anti-apoptosis protein, in the SMG. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL assay) showed no increase in the number of apoptotic cells in the SMG. CTD, however, induced strongly and transiently (at 1-3 days) the... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3845623 Wed, 04 Aug 2010 23:00:00 +0100 3845623 http://www.medworm.com/index.php?rid=3807312&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20668288%26dopt%3DAbstract Authors: PMID: 20668288 [PubMed - in process] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3807312 Sat, 31 Jul 2010 23:00:00 +0100 3807312 http://www.medworm.com/index.php?rid=3807311&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20671193%26dopt%3DAbstract Conclusion: ER stress response mechanisms are activated in pancreatic inflammation. Chemical chaperones enhance enzyme secretion of pancreatic acini, reduce ER stress responses and attenuate ER stress associated apoptosis. This data hints new perspectives for an employment of chemical chaperones in the therapy of acute pancreatitis. PMID: 20671193 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3807311 Wed, 28 Jul 2010 23:00:00 +0100 3807311 http://www.medworm.com/index.php?rid=3807310&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20671194%26dopt%3DAbstract In conclusion, this study showed that glucocorticoids inhibit NHE8 gene expression by increasing Pax5 binding on NHE8 gene promoter, suggesting an important role for Pax5 during intestinal maturation. PMID: 20671194 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3807310 Wed, 28 Jul 2010 23:00:00 +0100 3807310 http://www.medworm.com/index.php?rid=3807309&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20671195%26dopt%3DAbstract The objective of this study was to elucidate the mechanism by which Cdx2 regulates E-cadherin function. Two colon cancer cell lines were identified in which Cdx2 expression was associated with increased cell-cell adhesion and diminished cell migration. In both cell lines Cdx2 did not directly alter E-cadherin levels but increased its trafficking to the cell membrane compartment. Cdx2 enhanced this trafficking by altering receptor tyrosine kinase activity (RTK). Cdx2 expression diminished both phospho-Abl and phospho-Rac levels, which are downstream effectors of RTKs. Specific chemical inhibition or shRNA knockdown of c-Abl kinase phenocopied Cdx2's cell-cell adhesion effects. In Colo 205 cells, Cdx2 reduced PDGFR and IGF-1R receptor activation. This was mediated by Caveolin-1, which was in... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3807309 Wed, 28 Jul 2010 23:00:00 +0100 3807309 http://www.medworm.com/index.php?rid=3807308&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20671196%26dopt%3DAbstract Authors: Borthakur A, Anbazhagan AN, Kumar A, Raheja G, Singh V, Ramaswamy K, Dudeja PK The major short chain fatty acid (SCFA) butyrate is produced in the colonic lumen by bacterial fermentation of dietary fiber. Butyrate serves as primary fuel for the colonocytes and also ameliorates mucosal inflammation. Disturbed energy homeostasis seen in inflamed mucosa of IBD patients has been attributed to impaired absorption of butyrate. Since sodium-coupled monocarboxylate transporter 1 (SMCT1, SLC5A8) has recently been shown to play a role in Na+-coupled transport of monocarboxylates including SCFA such as luminal butyrate, we examined the effects of pro-inflammatory TNF-alpha on SMCT1 expression and function and potential anti-inflammatory role of probiotic Lactobacillus species in countera... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3807308 Wed, 28 Jul 2010 23:00:00 +0100 3807308 http://www.medworm.com/index.php?rid=3807307&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20671197%26dopt%3DAbstract Conclusions: Acinar cells are a likely source of KC and MIP-2 up-regulation during pancreatitis. This upregulation is dependent on calcium and PKC. MIP-2 upregulation requires both NF-kappaB and AP-1 in these cells. Thus, dual inhibition of NF-kappaB and AP-1 may be a more successful strategy to reduce inflammation in pancreatitis than targeting NF-kappaB alone. KEYWORDS: CXC-ELR, AP-1, NF-kB. PMID: 20671197 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3807307 Wed, 28 Jul 2010 23:00:00 +0100 3807307 http://www.medworm.com/index.php?rid=3762722&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F07%252F12%252012.30%2522%255BMHDA%255D%253A%25222010%252F07%252F18%252003.45%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F07%252F12%252012.30%2522%255BEDAT%255D%29%29 34 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/07/18PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3762722 Sun, 18 Jul 2010 07:45:02 +0100 3762722 http://www.medworm.com/index.php?rid=3737886&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F07%252F06%252021.51%2522%255BMHDA%255D%253A%25222010%252F07%252F09%252017.27%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F07%252F06%252021.51%2522%255BEDAT%255D%29%29 20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/07/09PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3737886 Fri, 09 Jul 2010 21:27:09 +0100 3737886 http://www.medworm.com/index.php?rid=3727433&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20595617%26dopt%3DAbstract Conclusions: Oxidative stress biases intestinal epithelial responses to flagellin, leading to increased production of IL-8 and decreased production of CCL20. This suggests that epithelial cells are capable of sensing the extracellular environment and adjusting their antimicrobial responses accordingly. PMID: 20595617 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3727433 Wed, 30 Jun 2010 23:00:00 +0100 3727433 http://www.medworm.com/index.php?rid=3727432&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20595618%26dopt%3DAbstract Authors: Sheth RA, Mahmood U Colorectal cancer remains a major cause of morbidity and mortality in the United States. The advent of molecular therapies targeted against specific, stereotyped cellular mutations that occur in this disease has ushered in new hope for treatment options. However, key questions regarding the optimal dosing schedules, dosing duration, and patient selection remain unanswered. In this review, we describe how recent advances in molecular imaging, specifically optical molecular imaging with fluorescent probes, offer potential solutions to these questions and may play a key role in improving outcomes. We begin with an overview of optical molecular imaging, including a discussion on the various methods of design for fluorescent probes and the clinically relevant im... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3727432 Wed, 30 Jun 2010 23:00:00 +0100 3727432 http://www.medworm.com/index.php?rid=3727431&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20595619%26dopt%3DAbstract Authors: Ge F, Zhou S, Hu C, Lobdell H, Berk PD Hepatic steatosis results from several processes. To assess their relative roles, hepatocellular long chain fatty acid (LCFA) uptake was assayed in hepatocytes from C57BL/6J control mice (C), mice with steatosis from a high fat diet (HFD) or 10, 14, or 18% ethanol (EtOH) in drinking water (functioning leptin signaling groups, FLSGs), and ob/ob and db/db mice. Uptake V(max) was increased vs C (p<0.001) and correlated significantly with liver weight and triglycerides in all FLSGs, but was minimally or not increased in ob/ob and db/db, in which liver weights & triglycerides greatly exceeded projections from regressions in FLSGs. Coefficients of determination (R(2)) for these FLSG regressions suggest that increased LCFA uptake accounts... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3727431 Wed, 30 Jun 2010 23:00:00 +0100 3727431 http://www.medworm.com/index.php?rid=3727430&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20595620%26dopt%3DAbstract This study employed high-resolution (HR) mapping to re-evaluate human gastric slow wave activity. HR mapping was performed in 12 patients with normal stomachs undergoing upper abdominal surgery, using flexible printed circuit board (PCB) arrays (inter-electrode distance 7.6 mm). Up to 6 PCBs (192 electrodes; 93 cm(2)) were used simultaneously. Slow wave activity was characterized by spatiotemporal mapping, and regional frequencies, amplitudes and velocities were defined and compared. Slow wave activity in the pacemaker region (mid to upper corpus, greater curvature) was of greater amplitude (mean 0.57 mV) and higher velocity (8.0 mm s(-1)) than the corpus (0.25 mV, 3.0 mm s(-1)), (p<0.001), and displayed isotropic propagation. A marked transition to higher amplitude and velocity activit... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3727430 Wed, 30 Jun 2010 23:00:00 +0100 3727430 http://www.medworm.com/index.php?rid=3727429&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20595621%26dopt%3DAbstract Authors: Abdrakhmanova GR, Alsharari S, Kang M, Damaj MI, Akbarali HI Controlled clinical trials of nicotine transdermal patch for treatment of ulcerative colitis have been shown to improve histological and global clinical scores of colitis. Here we report that nicotine (1 muM) suppresses in vitro hyperexcitability of colonic dorsal root ganglia (DRG) (L1-L2) neurons in the dextran sodium sulfate (DSS)-induced mouse model of acute colonic inflammation. Nicotine gradually reduced regenerative multiple-spike action potentials in colitis mice to a single action potential. Nicotine's effect on hyperexcitability of inflamed neurons was blocked in the presence of an alpha7 nicotinic acetylcholine receptor (nAChR) antagonist, methyllicaconitine (MLA), while choline, the alpha7 nAChR agonist, ... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3727429 Wed, 30 Jun 2010 23:00:00 +0100 3727429 http://www.medworm.com/index.php?rid=3727428&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20595622%26dopt%3DAbstract Authors: Samak G, Suzuki T, Bhargava A, Rao RK Gastrointestinal epithelium faces osmotic stress both at physiologic and pathophysiologic conditions. JNK activation is an immediate cellular response to osmotic stress. We investigated the effect of osmotic stress on intestinal epithelial barrier function and delineated the role of JNK2 in osmotic stress-induced tight junction (TJ) regulation in Caco-2 cell monolayers and ileum of Jnk(-/-) and Jnk2(-/-) mice. The role of JNK activation in osmotic stress-induced TJ disruption was evaluated using JNK-specific inhibitor and antisense oligonucleotides. Furthermore, the effect of cold restraint stress in vivo on TJ integrity was determined in rats. Osmotic stress disrupted TJs and barrier function in Caco-2 cell monolayers without affecting ce... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3727428 Wed, 30 Jun 2010 23:00:00 +0100 3727428 http://www.medworm.com/index.php?rid=3727427&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20595623%26dopt%3DAbstract CONCLUSIONS: Ethanol metabolism induces oxidative stress (GSH depletion and increased lipid peroxidation) and sustained IL-6 expression in rat PCLS. These phenomena precede and coincide with myofibroblast activation which occurs within 48h of treatment. These results indicate the PCLS can be used as in vitro model for studying multicellular interactions during the early stages of ethanol-induced liver injury and fibrogenesis. PMID: 20595623 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3727427 Wed, 30 Jun 2010 23:00:00 +0100 3727427 http://www.medworm.com/index.php?rid=3727426&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20595624%26dopt%3DAbstract Conclusions: IIS protects against the metabolic syndrome through short-circuiting enterohepatic bile acid recycling. There is early reabsorption of primary bile acids despite selective jejunization of the interposed ileal segment. Changes in serum bile acids or bile acid enterohepatic recycling may mediate the metabolic benefits seen after bariatric surgery. PMID: 20595624 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3727426 Wed, 30 Jun 2010 23:00:00 +0100 3727426 http://www.medworm.com/index.php?rid=3684592&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F06%252F16%252010.06%2522%255BMHDA%255D%253A%25222010%252F06%252F22%252021.45%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F06%252F16%252010.06%2522%255BEDAT%255D%29%29 29 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/06/22PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3684592 Wed, 23 Jun 2010 01:45:02 +0100 3684592 http://www.medworm.com/index.php?rid=3604165&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F05%252F24%252021.00%2522%255BMHDA%255D%253A%25222010%252F05%252F27%252016.39%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F05%252F24%252021.00%2522%255BEDAT%255D%29%29 17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/05/27PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3604165 Thu, 27 May 2010 20:39:04 +0100 3604165 http://www.medworm.com/index.php?rid=3567143&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20466941%26dopt%3DAbstract Conclusions: Colonisation of the colon by a complex microbiota increases the crypt depth of colon epithelium. This event takes place in conjunction with a multi-step process: a hyperproliferative boost accompanied by compensatory events as induction of p21(cip1) and p27( Kip1) and decrease of Bcl2. PMID: 20466941 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3567143 Wed, 12 May 2010 23:00:00 +0100 3567143 http://www.medworm.com/index.php?rid=3567142&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20466942%26dopt%3DAbstract Authors: Mannery YO, Ziegler TR, Hao LH, Shyntum Y, Jones DP Control of extracellular thiol-disulfide redox potential is necessary to protect cell surface proteins from external oxidative and reductive stresses. Previous studies show that human colonic epithelial Caco2 cells, which grow in cell culture with the apical surface exposed to the medium, regulate extracellular cysteine/cystine redox potential (E(h)) to physiologic values (~ -80 mV) observed in vivo. The present study tested whether extracellular E(h) regulation occurs on the basal surface of Caco2 cells and investigated relevant mechanisms. Experiments were performed with confluent, differentiated cells grown on a permeable membrane surface. Cells were exposed to an oxidizing potential (0 mV) using a fixed cysteine/cystine r... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3567142 Wed, 12 May 2010 23:00:00 +0100 3567142 http://www.medworm.com/index.php?rid=3567141&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20466943%26dopt%3DAbstract Authors: Talbot C, Lytle C The colon is believed to absorb NaCl via the coupled operation of apical Na/H exchanger-3 (NHE3) and Cl/HCO(3) exchanger SLC26A3 (DRA). Efficient coupling requires that NHE3 and DRA operate in close proximity within common luminal and cytosolic microenvironments. Thus, we examined whether these proteins coexist along the apical margin of surface enterocytes by quantitative immunofluorescence microscopy in consecutive colon segments from nonfasted mice and rats. The cecocolonic profiles of NHE3 and DRA expression were roughly inverse; NHE3 was highest in proximal colon (PC) and negligible in distal colon (DC), whereas DRA was absent in early PC and highest in the late mid-colon, and DRA was prominent in the cecum whereas NHE3 was not. NHE3 and DRA coexisted on... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3567141 Wed, 12 May 2010 23:00:00 +0100 3567141 http://www.medworm.com/index.php?rid=3543161&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F05%252F02%252004.18%2522%255BMHDA%255D%253A%25222010%252F05%252F07%252018.48%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F05%252F02%252004.18%2522%255BEDAT%255D%29%29 24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/05/07PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3543161 Fri, 07 May 2010 22:48:02 +0100 3543161 http://www.medworm.com/index.php?rid=3501772&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20413716%26dopt%3DAbstract Authors: Demitrack ES, Soleimani M, Montrose MH Gastric surface pH (pH(o)) transiently increases in response to focal epithelial damage. The source(s) of that increase, either from paracellular leakage of interstitial fluid or transcellular acid/base fluxes, have not been determined. Using in vivo microscopy approaches we measured pH(o) with Cl-NERF, tissue permeability with i.v. fluorescent-dextrans to label interstitial fluid (paracellular leakage), and gastric epithelial intracellular pH (pH(i)) with SNARF-5F (cellular acid/base fluxes). In response to two-photon photodamage, we found that cell-impermeant dyes entered damaged cells from luminal or tissue compartments, suggesting a possible slow transcellular, but not paracellular, route for increased permeability after damage. Regar... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3501772 Wed, 21 Apr 2010 23:00:00 +0100 3501772 http://www.medworm.com/index.php?rid=3501771&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20413717%26dopt%3DAbstract Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia and regenerative changes in the absence of "floxed" alleles. Am J Physiol Gastrointest Liver Physiol. 2010 Apr 22; Authors: Huh WJ, Mysorekar IU, Mills JC The epithelium of the mammalian gastric body comprises multiple cell types replenished by a single stem cell. The adult conformation of cell lineages occurs well after birth; hence, study of genes regulating stem cell activity is facilitated by inducible systems for gene deletion. However, there is a potential pitfall involving the commonly used inducible Cre recombinase system to delete genes: we report here that induction of Cre using standard doses of tamoxifen led to marked spasmolytic polypeptide-expressing metaplasia (SPE... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3501771 Wed, 21 Apr 2010 23:00:00 +0100 3501771 http://www.medworm.com/index.php?rid=3501770&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20413718%26dopt%3DAbstract Authors: Halm ST, Zhang J, Halm DR Adrenergic stimulation of isolated guinea pig distal colonic mucosa produced transient Cl(-) and sustained K(+) secretion. Transient short-circuit current (I(sc)) depended on beta2-adrenergic receptors (beta2-AdrR) and sustained I(sc) relies on a beta1-AdrR/beta2-AdrR complex. Epinephrine increased cAMP content with a biphasic time course similar to changes in I(sc). Inhibition of transmembrane adenylyl cyclases (tmAC) reduced peak (epi)I(sc) and cAMP to near zero without decreasing sustained (epi)I(sc), consistent with cAMP from tmAC signaling for only Cl(-) secretion. Inhibition of soluble adenylyl cyclase (sAC) reduced sustained (epi)I(sc) and cAMP to near zero without decreasing peak (epi)I(sc) or cAMP, consistent with cAMP from sAC signaling for ... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3501770 Wed, 21 Apr 2010 23:00:00 +0100 3501770 http://www.medworm.com/index.php?rid=3501769&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20413719%26dopt%3DAbstract Authors: Dickson EJ, Heredia DJ, Smith TK The colonic migrating motor complex (CMMC) is necessary for fecal pellet propulsion in the murine colon. We have previously shown that 5-hydroxytryptamine (5-HT) released from EC cells activates 5-HT(3) receptors on the mucosal processes of myenteric Dogiel type II neurons to initiate the events underlying the CMMC. Our aims were to further investigate the roles of 5-HT(1A), 5-HT(3) and 5-HT(7) receptor subtypes in generating and propagating the CMMC using intracellular microelectrodes or tension recordings from the circular muscle (CM) in preparations with and without the mucosa. Spontaneous CMMCs were recorded from the CM in isolated murine colons but not in preparations without the mucosa. In mucosa less preparations, ondansetron (3microM; 5... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3501769 Wed, 21 Apr 2010 23:00:00 +0100 3501769 http://www.medworm.com/index.php?rid=3501768&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20413720%26dopt%3DAbstract Authors: Coy DJ, Wooton-Kee CR, Yan B, Sabeva NS, Su K, Graf GA, Vore M Lactation is associated with increased expression of bile acid transporters and an increased size and hydrophobicity of the bile acid pool in rats. ATP-binding cassette transporters Abcb4, Abcb11 (Bsep), and Abcg5/Abcg8 heterodimers are essential for the biliary secretion of phospholipids, bile acids, and cholesterol, respectively. We investigated the expression of these transporters and secretion of their substrates in female control and lactating Sprague Dawley rats and C57BL/6 mice. Expression of Abcg5/Abcg8 mRNA was decreased by 97% and 60% by mid lactation in rats and mice respectively; protein levels of Abcg8 were below detection limits in lactating rats. Abcb4 mRNA expression was decreased in lactating rats ... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3501768 Wed, 21 Apr 2010 23:00:00 +0100 3501768 http://www.medworm.com/index.php?rid=3501767&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20413721%26dopt%3DAbstract Authors: Ulmasov B, Xu Z, Talkad V, Oshima K, Neuschwander-Tetri BA The intraorgan renin-angiotensin system (RAS) plays an important role in the pathophysiology of a variety of diseases and has been implicated in fibrogenesis. The role of RAS in the development of chronic pancreatitis is not well established. The blockade of RAS in rat models with angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor 1 (AT1) blockers (ARBs) mostly have reduced pancreatic inflammation and fibrosis with a few exceptions. At the same time, the use of ACEi and ARBs in humans is associated with a modest risk of acute pancreatitis. The aim of this study was to elucidate the effect of the AT1 signaling pathway in the development of pancreatitis using AT1a and AT1b deficient mice as well as t... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3501767 Wed, 21 Apr 2010 23:00:00 +0100 3501767 http://www.medworm.com/index.php?rid=3501766&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20413722%26dopt%3DAbstract In conclusion, PAR(1) and PAR(2) both induced Cl(-) secretion in the mouse cecum. The secretion mediated by PAR(1) probably occurred by activation of the receptor on the submucosal secretomotor neurons, resulting mainly in the release of tachykinins and activation of the neurokinin-1 receptor, and partly in the release of Ach and activation of the muscarinic and nicotinic receptors. On the other hand, PAR(2)-mediated Cl(-) secretion probably occurred by activating the receptor on the epithelial cells. PMID: 20413722 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3501766 Wed, 21 Apr 2010 23:00:00 +0100 3501766 http://www.medworm.com/index.php?rid=3481124&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F04%252F11%252012.16%2522%255BMHDA%255D%253A%25222010%252F04%252F19%252000.26%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F04%252F11%252012.16%2522%255BEDAT%255D%29%29 16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/04/19PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3481124 Mon, 19 Apr 2010 04:26:02 +0100 3481124 http://www.medworm.com/index.php?rid=3435679&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20360131%26dopt%3DAbstract Authors: Said HM, Mee L, Sekar VT, Ashokkumar B, Pandol SJ Folate plays an essential role in one-carbon metabolism, and a relationship exists between methyl group metabolism and pancreatic exocrine function. Little however is known about the mechanism(s) and regulation of folate uptake by pancreatic acinar cells and the effect of chronic alcohol use on the process. We addressed these issues using the rat-derived pancreatic acinar cell line AR42J and freshly isolated primary rat pancreatic acinar cells as models. We found (3)H-folic acid uptake to be: 1) temperature- and pH- dependent with a higher uptake at acidic than at neutral/alkaline pH; 2) saturable as a function of substrate concentration at both buffer pH 7.4 and 6.0; 3) inhibited by folate structural analogues and by anion tra... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3435679 Wed, 31 Mar 2010 23:00:00 +0100 3435679 http://www.medworm.com/index.php?rid=3435678&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20360132%26dopt%3DAbstract Conclusion: MPW observed during clinical motility studies are not indicative of repetitive esophageal contraction, rather they represent respiration-related movement of the contracted esophageal segment in relation to the stationary pressure sensor. PMID: 20360132 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3435678 Wed, 31 Mar 2010 23:00:00 +0100 3435678 http://www.medworm.com/index.php?rid=3435677&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20360133%26dopt%3DAbstract Authors: Zhang Y, Cong X, Shi L, Xiang B, Li YM, Ding QW, Ding C, Wu LL, Yu GY Hyposecretion occurrs in most patients early after submandibular gland autotransplantation for severe keratoconjunctivitis sicca. Endogenous transient receptor potential vanilloid subtype 1 (TRPV1) has been recently demonstrated in rabbit submandibular glands, and activation of TRPV1 by capsaicin increases secretion in isolated glands, but the TRPV1-mediated secretory mechanism remains to be elucidated. The purpose of this study was to verify whether activation of TRPV1 by capsaicin could improve the secretion of transplanted gland and its underlying mechanism. The salivary flow of the transplanted glands was significantly decreased, and the mRNA and protein levels of TRPV1 and aquaporin 5 (AQP5) were downre... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3435677 Wed, 31 Mar 2010 23:00:00 +0100 3435677 http://www.medworm.com/index.php?rid=3435676&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20360134%26dopt%3DAbstract In this study, we used video imaging and spatio-temporal mapping techniques to investigate the neuro-neuronal mechanisms underlying peristalsis in isolated guinea-pig distal colon. In direct contrast to previous studies, we found that hexamethonium (100microM-1mM) or mecamylamine (20microM) never abolished peristalsis or fecal pellet propulsion, although a temporary blockade of peristalsis was common, giving the impression perhaps that peristalsis was blocked permanently. During the initiation of peristalsis, the intraluminal propulsive force applied to an inserted fecal pellet was significantly reduced by hexamethonium 100microM, even though once initiated, the propagation velocity of fecal pellets was never reduced by nicotinic antagonists. In the presence of hexamethonium or mecamylamin... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3435676 Wed, 31 Mar 2010 23:00:00 +0100 3435676 http://www.medworm.com/index.php?rid=3435675&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20360135%26dopt%3DAbstract In this study, we examined the role of IL-4Ralpha-responsiveness by non-haematopoetic smooth muscle cells (SMC) during experimental acute murine schistosomiasis. Comparative S. mansoni infection studies with smooth muscle cell-specific IL-4Ralpha deficient (SM-MHC(cre)IL-4Ralpha(-/flox)) mice, heterozygous control (IL-4Ralpha(-/flox)) mice and global IL-4Ralpha deficient (IL-4Ralpha(-/-)) mice were conducted. S. mansoni-infected SM-MHC(cre)IL-4Ralpha(-/flox) mice showed increased weight loss and earlier mortalities compared to IL-4Ralpha(-/flox) mice; this despite comparable T(H)2/type2 immune responses. In contrast to highly susceptible IL-4Ralpha deficient mice, increased susceptibility in SM-MHC(cre)IL-4Ralpha(-/flox) mice was not accompanied by intestinal tissue damage and subsequent s... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3435675 Wed, 31 Mar 2010 23:00:00 +0100 3435675 http://www.medworm.com/index.php?rid=3411309&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338920%26dopt%3DAbstract Authors: Das A, Shergill U, Thakur L, Sinha S, Urrutia R, Mukhopadhyay D, Shah VH Chemotaxis signals between hepatic stellate cells (HSC) and sinusoidal endothelial cells (SEC) maintain hepatic vascular homeostasis and integrity and also regulate changes in sinusoidal structure in response to liver injury. Our prior studies have demonstrated that the bi-directional chemotactic signaling molecules EphrinB2 and EphB4 are expressed in HSC. The Aim of our present study was to explore if and how the EphrinB2/EphB4 system in HSC could promote SEC recruitment which is essential for sinusoidal structure and remodeling. Stimulation of human HSC (hHSC) with chimeric agonists (2 microg/mL) of either EphrinB2 or EphB4 significantly increased VEGF mRNA levels in hHSC as assessed by qPCR, with respe... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3411309 Thu, 25 Mar 2010 00:00:00 +0100 3411309 http://www.medworm.com/index.php?rid=3411308&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338921%26dopt%3DAbstract Authors: McGuckin MA, Eri RD, Das I, Lourie R, Florin TH Endoplasmic reticulum (ER) stress is a phenomenon that occurs when excessive protein misfolding occurs during biosynthesis. ER stress triggers a series of signalling and transcriptional events known as the unfolded protein response (UPR). The UPR attempts to restore homeostasis in the ER but if unsuccessful can trigger apoptosis in the stressed cells and local inflammation. Intestinal secretory cells are susceptible to ER stress because they produce large amounts of complex proteins for secretion, most of which are involved in mucosal defense. This review focuses on ER stress in intestinal secretory cells and describes how increased protein misfolding could occur in these cells, the process of degradation of misfolded proteins, t... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3411308 Thu, 25 Mar 2010 00:00:00 +0100 3411308 http://www.medworm.com/index.php?rid=3411307&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338922%26dopt%3DAbstract Authors: Pelletier AM, Venkataramana S, Miller KG, Bennett BM, Nair DG, Lourenssen SR, Blennerhassett MG Hyperplasia of smooth muscle contributes to the thickening of the intestinal wall that is characteristic of inflammation, but the mechanisms of growth control are unknown. Nitric oxide (NO) from enteric neurons expressing neuronal nitric oxide synthase might normally inhibit intestinal smooth muscle cell (ISMC) growth and this was tested in vitro. In ISMC from the circular smooth muscle of the adult rat colon, chemical NO donors inhibited (3)H-thymidine uptake in response to fetal calf serum (FCS), reducing this to baseline without toxicity. This effect was inhibited by the guanylyl cyclase inhibitor ODQ and potentiated by the phosphodiesterase-5 inhibitor zaprinast. Inhibition was ... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3411307 Thu, 25 Mar 2010 00:00:00 +0100 3411307 http://www.medworm.com/index.php?rid=3411306&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338923%26dopt%3DAbstract Conclusion: These studies establish a novel link between the cell cycle machinery and sex steroid metabolism, and provide a distinct mechanism by which cyclin D1 may regulate hormone signaling. Furthermore, these results suggest that increased cyclin D1 expression, which occurs in liver regeneration and liver diseases, may contribute to the feminization seen in these settings. PMID: 20338923 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3411306 Thu, 25 Mar 2010 00:00:00 +0100 3411306 http://www.medworm.com/index.php?rid=3411305&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338924%26dopt%3DAbstract In conclusion R-flurbiprofen at a dose of 30mg/kg BW per day was well tolerated by the animals and along with Sulindac at 30mg/day BW showed protection against the development of colon cancer in the rat-AOM model. PMID: 20338924 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3411305 Thu, 25 Mar 2010 00:00:00 +0100 3411305 http://www.medworm.com/index.php?rid=3411304&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338925%26dopt%3DAbstract Authors: Lu F, Fernandes SM, Davis AE The complement and contact systems may be involved in the pathophysiological process of inflammatory bowel disease (IBD). C1 inhibitor (C1INH) is the most important inhibitor of both the complement and contact systems. We evaluated the role of these systems and the effect of both active and inactive forms of C1 inhibitor (iC1INH) in dextran sulfate sodium (DSS)-induced colitis mouse model. 3% DSS was used in drinking water to induce colitis in complement C3 deficient (C3(-/-)) mice, bradykinin type 2 receptor deficient (Bk(2)R(-/-)) mice and C57 BL/6 mice. After ten days DSS exposure, C3(-/-) mice exhibited markedly less weight loss than WT mice (12+/-3.3% vs. 30+/-1.2%, p<0.05), developed a milder disease activity index (DAI), histological scor... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3411304 Thu, 25 Mar 2010 00:00:00 +0100 3411304 http://www.medworm.com/index.php?rid=3375024&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F03%252F14%252011.02%2522%255BMHDA%255D%253A%25222010%252F03%252F18%252004.54%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F03%252F14%252011.02%2522%255BEDAT%255D%29%29 18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/03/18PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3375024 Thu, 18 Mar 2010 08:54:02 +0100 3375024 http://www.medworm.com/index.php?rid=3313828&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185687%26dopt%3DAbstract Authors: Gracz AD, Ramalingam S, Magness ST The inability to identify, isolate, and culture intestinal epithelial stem cells (IESCs) has been prohibitive to the study and therapeutic utilization of these cells. Using a Sox9(EGFP) mouse model, we demonstrate that Sox9(EGFP) fluorescence signatures can be used to differentiate between and enrich for progenitors (Sox9(EGFPsubLo)) and multipotent IESCs (Sox9(EGFPlo)). Sox9(EGFPlo) cells generate 'organoids' in a recently defined culture system that mimics the native IESC niche. These organoids possess all four differentiated cell types of the small intestine epithelium demonstrating the multipotent capacity of Sox9(EGFPlo) cells. Our results are consistent with the previously reported observation that single IESCs generate crypt-like units... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3313828 Thu, 25 Feb 2010 00:00:00 +0100 3313828 http://www.medworm.com/index.php?rid=3313826&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185688%26dopt%3DAbstract Authors: Goetz M, Kiesslich R Confocal endomicroscopy is a novel technique that permits in vivo microscopy of the human gastrointestinal mucosa during ongoing endoscopy, thereby providing optical virtual biopsies. Endomicroscopy has been demonstrated to reveal histologic information in a multitude of diseases in the upper and lower gastrointestinal tract in vivo. Most studies have focused on inflammation and neoplasia, such as Barrett's esophagus, gastric cancer, celiac disease, Crohn's disease and ulcerative colitis, or colorectal neoplasias. Endomicroscopy allows obtaining "smart", targeted biopsies from regions with microscopic alterations rather than having to rely on random untargeted tissue sampling. This reduces the number of biopsies while increasing the diagnostic yield. In ad... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3313826 Thu, 25 Feb 2010 00:00:00 +0100 3313826 http://www.medworm.com/index.php?rid=3313825&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185689%26dopt%3DAbstract This study examined whether release of sympathetic purines can modulate dilator nerves. In vitro submucosal preparations from guinea-pig ileum were modified to leave the parent mesenteric artery intact so that perivascular sympathetic and extrinsic afferent nerves could be activated by a bipolar stimulating electrode placed on the parent artery, and submucosal vasodilator neurons were activated using focal electrodes placed on submucosal ganglia. The outside diameter of submucosal arterioles was monitored using videomicroscopy and dilator responses were examined after preconstricting vessels 80-95 % with prostaglandin F2alpha (400 nM). Mesenteric nerve stimulation evoked a frequency-dependent dilation, with suramin (100 muM) present throughout to inhibit P2X receptor-mediated vasoconstrict... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3313825 Thu, 25 Feb 2010 00:00:00 +0100 3313825 http://www.medworm.com/index.php?rid=3313824&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185690%26dopt%3DAbstract In this study, we have explored the role of tetrahydrobiopterin (BH4), a major co-factor for nNOSalpha activity and NO synthesis in diabetic gastroparesis. Diabetes was induced with single injection of streptozotocin (55 mg/Kg b.w, i.p.) in female rats, with experiments performed on week 3 or 9 following induction, with or without three week BH4 supplementation. Gastric pyloric BH4 levels were significantly decreased in diabetic female rats compared to control (18.6+/-1.45 vs. 31.0+/-2.31pmol/mg protein). In vitro studies on pyloric strips showed that 2, 4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor of BH4 synthesis, significantly decreased NO release and nitrergic relaxation. Three week dietary supplementation of BH4 either from day 1 or 6 wk significantly attenuated diabetes-induced... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3313824 Thu, 25 Feb 2010 00:00:00 +0100 3313824 http://www.medworm.com/index.php?rid=3313823&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185691%26dopt%3DAbstract Authors: Fujita Y, Asadi A, Yang GK, Kwok YN, Kieffer TJ Glucose-dependent insulinotropic polypeptide (GIP) is a hormone released from enteroendocrine K-cells in response to meals. Post-translational processing of the precursor protein proGIP at residue 65 by proprotein convertase subtilisin/kexin type 1 (PC1/3) in gut K-cells gives rise to the established 42 amino acid form of GIP (GIP(1-42)). However, the proGIP peptide sequence contains a consensus cleavage site for PC2 at residues 52-55 and we identified PC2 immunoreactivity in a subset of K-cells, suggesting the potential existence of a C-terminal truncated GIP isoform, GIP(1-30). Indeed a subset of mouse and human K-cells display GIP immunoreactivity with GIP antibodies directed to the mid portion of the peptide, but not with a C... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3313823 Thu, 25 Feb 2010 00:00:00 +0100 3313823 http://www.medworm.com/index.php?rid=3313820&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185692%26dopt%3DAbstract Authors: Cesaro A, Brest P, Hofman V, Hébuterne X, Wildman S, Ferrua B, Marchetti S, Doglio A, Vouret-Craviari V, Galland F, Naquet P, Mograbi B, Unwin RJ, Hofman PM Inflammatory bowel diseases (IBD) are characterized during their active phase by polymorphonuclear leukocyte (PMNL) transepithelial migration. The efflux of PMNL into the mucosa is associated with the production of pro-inflammatory cytokines and the release of ATP from damaged and necrotic cells. The expression and function of purinergic P2X(7) receptors (P2X(7)R) in intestinal epithelial cells (IEC), and its potential role in the 'cross-talk' between IEC and PMNL, have not been explored. The aims of the present study were: i) to examine P2X(7)R expression in IEC (T84 cells) and in human intestinal biopsies; ii) to de... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3313820 Thu, 25 Feb 2010 00:00:00 +0100 3313820 http://www.medworm.com/index.php?rid=3292243&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222010%252F02%252F16%252004.56%2522%255BMHDA%255D%253A%25222010%252F02%252F21%252019.58%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F02%252F16%252004.56%2522%255BEDAT%255D%29%29 25 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2010/02/21PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3292243 Mon, 22 Feb 2010 00:58:03 +0100 3292243 http://www.medworm.com/index.php?rid=3247466&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20133949%26dopt%3DAbstract Conclusion: Our findings suggest the presence of altered myocardial function in PBC. Autonomic "dysfunction" may, rather than being an abnormal process, represent a compensatory mechanism to increase cardiac return to mitigate these effects. PMID: 20133949 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3247466 Thu, 04 Feb 2010 00:00:00 +0100 3247466 http://www.medworm.com/index.php?rid=3247465&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20133950%26dopt%3DAbstract Authors: Vegesna AK, Braverman AS, Miller LS, Tallarida RJ, Tiwana MI, Khayyam U, Ruggieri MR To compare the gastroesophageal junction of the human with the pig, M(2) and M(3) receptor densities and the potencies of M(2) and M(3) muscarinic receptor subtype selective antagonists were determined in gastric clasp and sling smooth muscle fibers. Total muscarinic and M(2) receptors are higher in pig than human clasp and sling fibers. M(3) receptors are higher in human compared to pig sling fibers but lower in human compared to pig clasp fibers. Clasp fibers have fewer M(3) receptors than sling fibers in both humans and pigs. Similar to human clasp fibers, pig clasp fibers contract significantly less than pig sling fibers. Analysis of the methoctramine Schild plot suggests that M(2) recepto... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3247465 Thu, 04 Feb 2010 00:00:00 +0100 3247465 http://www.medworm.com/index.php?rid=3247464&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20133951%26dopt%3DAbstract Authors: Singh P, Sarkar S, Umar S, Rengifo-Cam W, Singh AP, Wood TG Progastrin and insulin-like-growth-factors (IGFs) stimulate hyperproliferation of intestinal epithelial cells (IECs) via endocrine/paracrine routes; hyperproliferation is a known risk factor for colon carcinogenesis. In the current study, inhibitory potency of curcumin in the presence or absence of progastrin/IGF-II was examined. Progastrin and IGF-II significantly increased proliferation of an immortalized IEC cell line, IEC-18, while Curcumin decreased the proliferation in a dose-dependent manner. IGF-II was significantly more effective than progastrin in reversing anti-proliferative effects of curcumin, and reversed pro-apoptotic effects of curcumin by >80%; progastrin was relatively ineffective towards reversin... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3247464 Thu, 04 Feb 2010 00:00:00 +0100 3247464 http://www.medworm.com/index.php?rid=3247463&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20133952%26dopt%3DAbstract Authors: Benoit YD, Paré F, Francoeur C, Jean D, Tremblay E, Boudreau F, Escaffit F, Beaulieu JF In the intestinal epithelium, the Cdx, GATA and HNF transcription factor families are responsible for the expression of differentiation markers such as sucrase-isomaltase. Although previous studies have shown that Cdx2 can induce differentiation in rat intestinal IEC-6 cells, no data are available concerning the direct implication of transcription factors on differentiation in human normal intestinal epithelial cell types. We investigated the role of Cdx2, GATA-4 and HNF-1alpha using the undifferentiated human intestinal epithelial crypt cell line HIEC. These transcription factors were tested on proliferation and expression of polarization and differentiation markers. Ectopic expressio... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3247463 Thu, 04 Feb 2010 00:00:00 +0100 3247463 http://www.medworm.com/index.php?rid=3221711&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20110459%26dopt%3DAbstract Authors: Hu S, Claud EC, Musch MW, Chang EB Mucosal inflammation, through cytokines like interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha), has many effects on the intestinal epithelium, including selective translational inhibition of the cytoprotective protein heat shock protein 70 (Hsp70). To further elucidate the mechanisms underlying this effect, we examined the role of stress granules in mediating the actions of these pro-inflammatory cytokines. Using conditionally-immortalized young adult mouse colonic epithelial cells, we demonstrate that IFN-gamma and TNF-alpha, which up-regulate eukaryotic initiation factor-alpha (eIF-2alpha) phosphorylation and reduce Hsp70 translation, significantly enhance stress granule formation in heat-shocked intestinal epithelial... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3221711 Thu, 28 Jan 2010 00:00:00 +0100 3221711 http://www.medworm.com/index.php?rid=3221710&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20110460%26dopt%3DAbstract In conclusion, multiple pregnancies do not reduce body iron stores in Hfe-/- mice. PMID: 20110460 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3221710 Thu, 28 Jan 2010 00:00:00 +0100 3221710 http://www.medworm.com/index.php?rid=3221703&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20110461%26dopt%3DAbstract Authors: Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE Anion secretion by colonic epithelium is dependent on apical CFTR-mediated anion conductance and basolateral ion transport. In many tissues, the NKCC1 Na(+)-K(+)-2Cl(-) cotransporter mediates basolateral Cl(-) uptake. However, additional evidence suggests that the AE2 Cl(-)/HCO(3)(-) exchanger, when coupled with the NHE1 Na(+)/H(+) exchanger or a Na(+)-HCO(3)(-) cotransporter (NBC), contributes to HCO(3)(-) and/or Cl(-) uptake. To analyze the secretory functions of AE2 in proximal colon, short-circuit current (I(sc)) responses to cAMP and inhibitors of basolateral anion transporters were measured in muscle-stripped wild-type (WT) and AE2-null (AE2(-/-)) proximal colon. In physiologic Ringers, the magnitude of cAMP-stimulate... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3221703 Thu, 28 Jan 2010 00:00:00 +0100 3221703 http://www.medworm.com/index.php?rid=3221702&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20110462%26dopt%3DAbstract Authors: Romac JM, Ohmuraya M, Bittner C, Majeed MF, Vigna SR, Que J, Fee BE, Wartmann T, Yamamura KI, Liddle RA Endogenous trypsin inhibitors are synthesized, stored and secreted by pancreatic acinar cells. It is believed that they play a protective role in the pancreas by inhibiting trypsin within the cell should trypsinogen become prematurely activated. Rodent trypsin inhibitors are highly homologous to human serine protease inhibitor Kazal-type 1 (SPINK1). The mouse has one pancreatic trypsin inhibitor known as SPINK3 while the rat has two trypsin inhibitors commonly known as pancreatic secretory trypsin inhibitors I and II (PSTI-I and -II). Rat PSTI-I is a 61 amino acid protein that shares 65% sequence identity with mouse SPINK3. It was recently demonstrated that mice with genetic... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3221702 Thu, 28 Jan 2010 00:00:00 +0100 3221702 http://www.medworm.com/index.php?rid=3221701&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20110463%26dopt%3DAbstract In this study, we tested the involvement of miRNA-mediated posttranscriptional regulation in IFN-gamma-induced ICAM-1 expression in cholangiocytes. Using both immortalized and non-immortalized human cholangiocyte cell lines, we found that IFN-gamma activated ICAM-1 transcription and increased ICAM-1 protein expression. Inhibition of ICAM-1 transcription could only partially block IFN-gamma-induced ICAM-1 expression at the protein level. In silico target prediction analysis revealed complementarity of miR-221 to the 3'-untranslated region of ICAM-1 mRNA. Targeting of ICAM-1 3'-untranslated region by miR-221 resulted in translational repression in cholangiocytes, but not ICAM-1 mRNA degradation. Functional inhibition of miR-221 with anti-miR-221 induced ICAM-1 protein expression. Moreover, I... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3221701 Thu, 28 Jan 2010 00:00:00 +0100 3221701 http://www.medworm.com/index.php?rid=3156886&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20056894%26dopt%3DAbstract In conclusion, our data demonstrate a novel role of lipid rafts in the modulation of ASBT function by the dietary component EGCG, which may underlie the hypocholesterolemic of green tea. PMID: 20056894 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3156886 Thu, 07 Jan 2010 00:00:00 +0100 3156886 http://www.medworm.com/index.php?rid=3156885&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20056895%26dopt%3DAbstract Authors: Blomme BA, Van Steenkiste C, Vanhuysse J, Colle I, Callewaert N, Van Vlierberghe H The GlycoFibroTest and GlycoCirrhoTest are non-invasive alternatives for liver biopsy that can be used as a follow-up tool for fibrosis patients and to diagnose cirrhotic patients, respectively. These tests are based on the altered N-glycosylation of total serum protein. Our aim was to investigate the impact of etiology on the alteration of N-glycosylation and if other characteristics of liver patients could have an influence on N-glycosylation. In human liver patients, no specific alteration could be found to make a distinction according to etiological factor, although alcoholic patients had a significant higher mean value for the GlycoCirrhioTest. Undergalactosylation did not show a significan... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3156885 Thu, 07 Jan 2010 00:00:00 +0100 3156885 http://www.medworm.com/index.php?rid=3156884&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20056896%26dopt%3DAbstract Conclusions: Reconstruction of bile flow after BDL leads to an orchestrated fibrolytic program that results in near complete reversal of advanced fibrosis. The peak of connective tissue remodeling and fibrolytic activity is associated with massive apoptosis of cholangiocytes and their phagocytic clearance by macrophages in vivo. Macrophages upregulate MMPs and become fibrolytic effector cells upon apoptotic cholangiocyte engulfment in vitro, suggesting that phagocytosis-associated MMP induction in macrophages significantly contributes to biliary fibrosis reversal. PMID: 20056896 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3156884 Thu, 07 Jan 2010 00:00:00 +0100 3156884 http://www.medworm.com/index.php?rid=3156883&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20056897%26dopt%3DAbstract Conclusion: These results clearly demonstrate that 15D-PGJ(2) inhibits the inflammatory response and endothelial cell damage seen in acute obstructive cholangitis, and could contribute to improve the outcome of this pathology. PMID: 20056897 [PubMed - as supplied by publisher] (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3156883 Thu, 07 Jan 2010 00:00:00 +0100 3156883 http://www.medworm.com/index.php?rid=3156882&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20056898%26dopt%3DAbstract Authors: Parsons SP, Huizinga JD Interstitial cells of Cajal are the pacemakers of the gut, initiating slow wave activity. Several ion channels have been identified that contribute to the depolarization phase of the slow wave. Our aim was to contribute to knowledge about the identity and role of ICC potassium channels in pacemaking. Here we describe a transient outward potassium current in cell-attached patches of ICC. This current was activated almost instantaneously at potentials positive of the resting membrane potential and inactivated as a single- or bi-exponential with time constants that varied widely from patch to patch. Averaged traces gave a bi-exponential inactivation with time constants of ~40 ms and ~500 ms, with no clear voltage dependence. Analysis of single-channel open... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3156882 Thu, 07 Jan 2010 00:00:00 +0100 3156882 http://www.medworm.com/index.php?rid=3108896&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20023227%26dopt%3DAbstract Authors: Hobson AR, Chizh B, Hicks K, Aziz Q, Worthen S, Lawrence P, Dewit O, Boyle Y, Dukes G Noxious stimuli in the esophagus cause pain that is referred to the anterior chest wall because of convergence of visceral and somatic afferents within the spinal cord. We sought to characterize the neurophysiological responses of these convergent spinal pain pathways in humans by studying 12 healthy subjects over three visits (V1, V2, and V3). Esophageal pain thresholds (Eso-PT) were assessed by electrical stimulation and anterior chest wall pain thresholds (ACW-PT) by use of a contact heat thermode. Esophageal evoked potentials (EEP) were recorded from the vertex following 200 electrical stimuli, and anterior chest wall evoked potentials (ACWEP) were recorded following 40 heat pulses. The f... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3108896 Tue, 22 Dec 2009 13:26:05 +0100 3108896 http://www.medworm.com/index.php?rid=3101507&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%29%2520AND%2520%25222009%252F12%252F05%252015.56%2522%255BMHDA%255D%253A%25222009%252F12%252F18%252015.22%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Gastrointest%2520Liver%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222009%252F12%252F05%252015.56%2522%255BEDAT%255D%29%29 29 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Gastrointest Liver Physiol These pubmed results were generated on 2009/12/18PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Gastroi...) Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3101507 Fri, 18 Dec 2009 20:22:02 +0100 3101507 http://www.medworm.com/index.php?rid=3060067&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19959817%26dopt%3DAbstract Authors: Ma J, Harnett KM, Behar J, Biancani P, Cao W TRPV1 receptors were identified in HET-1A cells by RT-PCR, and by Western blot. In Fura-2AM loaded cells, the TRPV1 agonist capsaicin caused a 4-fold cytosolic calcium increase, supporting a role of TRPV1 as a capsaicin-activated cation channel. Capsaicin increased production of PAF, an important inflammatory mediator that acts as a chemoattractant and activator of immune cells. The increase was reduced by the p38 MAP kinase (p38) inhibitor SB203580, by the cytosolic phospholipase A2 (cPLA2) inhibitor AACOCF3 and by the lyso-PAF acetyltransferase inhibitor sanguinarin, indicating that capsaicin-induced PAF production may be mediated by activation of cPLA2, p38 and lyso-PAF acetyltransferase. To establish a sequential signaling pathw... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3060067 Thu, 03 Dec 2009 00:00:00 +0100 3060067 http://www.medworm.com/index.php?rid=3060066&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19959818%26dopt%3DAbstract Authors: Dickson EJ, Heredia DJ, McCann CJ, Hennig GW, Smith TK Colonic migrating motor complexes (CMMCs) propel fecal contents and are altered in diseased states, including slow transit constipation. However, the mechanisms underlying the CMMC are controversial, since it has been proposed that 'disinhibition' (turning off of inhibitory neurotransmission) or excitatory nerve activity generate the CMMC. Therefore our aims were to reexamine the mechanisms underlying the CMMC in the colon of wild-type and nNOS (-/-) mice. CMMCs were recorded from the isolated murine large bowel using intracellular recordings of electrical activity from circular muscle (CM) combined with tension recording. Spontaneous CMMCs occurred in both wild type (frequency: 0.3 c/min) and nNOS(-/-) mice (frequency: 0.... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3060066 Thu, 03 Dec 2009 00:00:00 +0100 3060066 http://www.medworm.com/index.php?rid=3060065&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19959819%26dopt%3DAbstract In this study we explored the distribution of these channels in vagal afferents by quantitative PCR after a capsaicin treatment to eliminate capsaicin-sensitive neurons, and by single-cell PCR measurements in vagal afferent neurons cultured after retrograde labeling from the stomach or duodenum. We found that TRPC1/3/5/6, TRPV1-4, TRPM8, TRPA1, TWIK2, TRAAK, TREK1, and TASK1/2 were all present in rat nodose ganglia. Both lesion results and single-cell PCR results suggested that TRPA1 and TRPC1 were preferentially expressed in neurons that were either capsaicin-sensitive or TRPV1-positive. Expression of TRPM8 varied dynamically after various manipulations, which perhaps explains the disparate results obtained by different investigators. Last, we also examined ion channel distribution with t... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3060065 Thu, 03 Dec 2009 00:00:00 +0100 3060065 http://www.medworm.com/index.php?rid=3004814&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19910524%26dopt%3DAbstract Authors: Singla A, Dwivedi A, Saksena S, Gill RK, Alrefai WA, Ramaswamy K, Dudeja PK Lysophosphatidic acid (LPA), a potent bioactive phospholipid, is a natural component of food products like soy and egg yolk. LPA modulates a number of epithelial functions and has been shown to inhibit cholera toxin induced diarrhea. Anti-diarrheal effects of LPA are known to be mediated by inhibiting chloride secretion. However, the effects of LPA on chloride absorption in the mammalian intestine are not known. The present studies examined the effects of LPA on apical Cl(-)/OH(-) exchangers known to be involved in chloride absorption in intestinal epithelial cells. Caco-2 cells were treated with LPA and Cl(-)/OH(-) exchange activity was measured as DIDS-sensitive (36)Cl(-) uptake. Cell surface biotiny... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3004814 Thu, 12 Nov 2009 00:00:00 +0100 3004814 http://www.medworm.com/index.php?rid=3004813&cid=s_30378_17_f&fid=30378&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19910525%26dopt%3DAbstract Authors: Lautenschläger I, Dombrowsky H, Frerichs I, Kuchenbecker SC, Bade S, Schultz H, Zabel P, Scholz J, Weiler N, Uhlig S Intestinal edema remains a serious clinical problem and novel approaches to study its pathophysiology are needed. It was our aim to develop a long term stable isolated perfused rat small bowel preparation permitting analysis of vascular, luminal, interstitial and lymphatic compartments and to demonstrate the utility of this model by studying the effects of the pro-inflammatory mediator platelet-activating factor (PAF). A temperature-controlled chamber with an integrated balance was designed to perfuse isolated intestines through the mesenteric artery and the gut lumen. Steroids or oxygen carriers were not needed. Functional and morphological integrity of th... Am J Physiol Gastroi... journals http://www.medworm.com/rss/comments.php?id=3004813 Thu, 12 Nov 2009 00:00:00 +0100 3004813