MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Am J Physiol Heart C...' source. Wed, 08 Feb 2012 09:32:26 +0100 http://www.medworm.com/index.php?rid=5661193&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22287581%26dopt%3DAbstract Conclusions: CaMKIIδ KO cannot suppress severe pressure-overload-induced HF. Although cellular contractility is improved, it reduces in vivo cardiac reserve to β-adrenergic regulation and deteriorates diastolic function. Our findings challenge the strategy of CaMKII inhibition in HF. PMID: 22287581 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5661193 Fri, 27 Jan 2012 05:00:00 +0100 5661193 http://www.medworm.com/index.php?rid=5661192&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22287582%26dopt%3DAbstract Authors: Zachara NE Abstract More than 1000 proteins of the nucleus, cytoplasm, and mitochondria are dynamically modified by O-linked β-N-acetylglucosamine (O-GlcNAc), an essential post-translational modification of metazoans. O-GlcNAc, which modifies Ser/Thr residues, is thought to regulate protein function in a manner analogous to protein phosphorylation and on a subset of proteins appears to have a reciprocal relationship with phosphorylation. Like phosphorylation, O-GlcNAc levels change dynamically in response to numerous signals including hyperglycemia and cellular injury. Recent data suggests that O-GlcNAc appears to be a key regulator of the cellular stress response, augmentation of which is protective in models of acute vascular injury, trauma hemorrhage and ischemia reper... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5661192 Fri, 27 Jan 2012 05:00:00 +0100 5661192 http://www.medworm.com/index.php?rid=5661190&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22287583%26dopt%3DAbstract Conclusions:</BOLD> The gain-of-function LQT3 murine Scn5a+/ΔKPQ cardiac system, in overlap with corresponding features reported in loss-of-function Na(+) channel mutations, shows compromised SAN pacemaker and conduction function explicable in modeling studies through a combination of augmented tail and reduced peak Na(+) currents. PMID: 22287583 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5661190 Fri, 27 Jan 2012 05:00:00 +0100 5661190 http://www.medworm.com/index.php?rid=5661189&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22287584%26dopt%3DAbstract Conclusions: These findings challenge the canonical belief that PO suppresses overall matrix proteolytic activity, but rather supports the concept that certain proteases, such as MT1-MMP, play a pivotal role in pressure-overload induced matrix remodeling and fibrosis. PMID: 22287584 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5661189 Fri, 27 Jan 2012 05:00:00 +0100 5661189 http://www.medworm.com/index.php?rid=5661188&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22287585%26dopt%3DAbstract Conclusion. Under MVD conditions, FFR, CDP, and LFC were not significantly influenced by changes in HR while they can significantly distinguish %AS and DP groups. PMID: 22287585 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5661188 Fri, 27 Jan 2012 05:00:00 +0100 5661188 http://www.medworm.com/index.php?rid=5661187&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22287586%26dopt%3DAbstract Authors: Dupont S, Maizel J, Mentaverri R, Chillon JM, Six I, Giummelly P, Brazier M, Choukroun G, Tribouilloy C, Massy ZA, Slama M Abstract Left ventricular (LV) diastolic dysfunction, particularly relaxation abnormalities, are known to be associated with the development of left ventricular hypertrophy (LVH). Preliminary human and animal studies suggested that early LV diastolic dysfunction may be revealed independently of LVH. However, whether LV diastolic dysfunction is compromised before the onset of hypertension and LVH remains unknown. We therefore evaluated LV diastolic function in spontaneously hypertensive rats (SHR) at different ages and tested whether LV diastolic dysfunction is associated with abnormal intracellular calcium homeostasis. LV systolic and diastolic functio... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5661187 Fri, 27 Jan 2012 05:00:00 +0100 5661187 http://www.medworm.com/index.php?rid=5661186&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22287587%26dopt%3DAbstract Conclusions: Our results suggest that sympathetic activity plays a role in hypertension. NO tonically restrains blood pressure by ~30 mmHg, but we found no evidence of impaired modulation by NO of vascular tone contributing to the early development of hypertension. If NO deficiency contributes to hypertension, it is likely to be due through interactions with the autonomic nervous system, which were excluded in this study. PMID: 22287587 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5661186 Fri, 27 Jan 2012 05:00:00 +0100 5661186 http://www.medworm.com/index.php?rid=5625577&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222012%252F01%252F12%252011.42%2522%255BMHDA%255D%253A%25222012%252F01%252F25%252002.29%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222012%252F01%252F12%252011.42%2522%255BEDAT%255D%29%29 54 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2012/01/25PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5625577 Wed, 25 Jan 2012 07:29:59 +0100 5625577 http://www.medworm.com/index.php?rid=5579638&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227124%26dopt%3DAbstract Authors: Lu PJ, Yang CF, Wu MY, Hung CH, Chan MY, Hsu TC Abstract A novel wave intensity analysis (WIA) was used to delineate and maximize the efficacy of a newly developed para-aortic blood pump (PABP). The gold-standard intra-aortic balloon pump (IABP) was employed as the comparison benchmark. Acute porcine experiments using 8 pigs, randomly divided into IABP (n=4) and PABP (n=4) groups, were conducted to compare the characteristics of intra- and para-aortic counterpulsation. We measured pressure and velocity with probes installed in the left anterior descending (LAD) coronary artery and aorta, during and without PABP assistance. Wave intensity for aortic and left coronary waves were derived from pressure and flow measurements with synchronization correction applied. To achieve m... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5579638 Fri, 06 Jan 2012 05:00:00 +0100 5579638 http://www.medworm.com/index.php?rid=5579637&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227125%26dopt%3DAbstract In conclusion, pharmacological activation or genetic deletion of CB(2) receptors modulate neointima formation via protective effects in macrophages and smooth muscle cells. PMID: 22227125 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5579637 Fri, 06 Jan 2012 05:00:00 +0100 5579637 http://www.medworm.com/index.php?rid=5579636&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227126%26dopt%3DAbstract Authors: Putnam K, Shoemaker R, Yiannikouris F, Cassis LA Abstract The renin-angiotensin system (RAS) is an important therapeutic target in the treatment of hypertension. Obesity has emerged as a primary contributor to essential hypertension in the US, and clusters with other metabolic disorders (hyperglycemia, hypertension, high triglycerides, low HDL cholesterol) defined within the metabolic syndrome. In addition to hypertension, RAS blockade may also serve as an effective treatment strategy to control impaired glucose and insulin tolerance and dyslipidemias in patients with the metabolic syndrome. Hyperglycemia, insulin resistance, and/or specific cholesterol metabolites have been demonstrated to activate components required for the synthesis (angiotensinogen, renin, ACE), degra... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5579636 Fri, 06 Jan 2012 05:00:00 +0100 5579636 http://www.medworm.com/index.php?rid=5579635&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227127%26dopt%3DAbstract Authors: Pires AL, Pinho M, Sena CM, Seiça RM, Leite-Moreira AF Abstract Intermedin (IMD) is a novel vasoactive peptide from the calcitonin gene-related peptide (CGRP) implicated in cardiac regulation, yet the contractile effects of IMD remain controversial, since previous studies in vivo and isolated cardiomyocytes documented contradictory results. We hypothesized cardiac endothelial cells involvement in IMD modulation of cardiac function as an explanation for these opposing observations. With this in mind, we investigated the direct action of increasing concentrations of IMD (10(-8) to 10(-6)M) on myocardial performance parameters in rat left ventricular (LV) papillary muscles with and without endocardial endothelium (EE) and in presence of receptor antagonists and intracellular... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5579635 Fri, 06 Jan 2012 05:00:00 +0100 5579635 http://www.medworm.com/index.php?rid=5579634&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22227128%26dopt%3DAbstract Authors: Storch U, Mederos Y Schnitzler M, Gudermann T Abstract Mechanosensation and -transduction are important for physiological processes like the senses of touch, hearing and balance. The mechanisms underlying the translation of mechanical stimuli into biochemical information by activating various signaling pathways play a fundamental role in physiology and pathophysiology, but are only poorly understood. Recently, G protein-coupled receptors (GPCRs), which are essential for the conversion of light, olfactory and gustatory stimuli as well as of primary messengers like hormones and neurotransmitters into cellular signals and play distinct roles in inflammation, cell growth and differentiation, have emerged as potential mechanosensors. The first candidate for a mechanosensitive G... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5579634 Fri, 06 Jan 2012 05:00:00 +0100 5579634 http://www.medworm.com/index.php?rid=5564785&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22210747%26dopt%3DAbstract Authors: Chang HH, Lee YC, Chen MF, Kuo JS, Lee TJ Abstract The close apposition between sympathetic and parasympathetic nerve terminals in the adventitia of cerebral arteries provides morphological evidence that sympathetic nerve activation causes parasympathetic nitrergic vasodilation via sympathetic-parasympathetic-interaction mechanism. The decreased parasympathetic nerve terminals in basilar arteries (BA) of spontaneously hypertensive rat (SHR) and renovascular hypertensive rats (RHR) comparing to Wistar-Kyoto rats (WKY), therefore, would diminish this axo-axonal-interaction-mediated neurogenic vasodilation in hypertension. Increased basilar arterial blood flow (BABF) via axo-axonal interaction during sympathetic activation was, therefore, examined in anesthetized rats by lase... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5564785 Fri, 30 Dec 2011 05:00:00 +0100 5564785 http://www.medworm.com/index.php?rid=5564784&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22210748%26dopt%3DAbstract Authors: Ghosh E, Kovács SJ Abstract Global left ventricular (LV) isovolumic relaxation rate has been characterized: 1) via the time-constant of isovolumic relaxation τ or 2) via the logistic time-constant τ(L). An alternate kinematic method, characterizes isovolumic relaxation (IVR) in accordance with Newton's Second Law. The model's parameters - stiffness E(k), and damping/relaxation μ result from best fit of model-predicted pressure to in-vivo data. All three models (exponential, logistic and kinematic) characterize global relaxation in terms of pressure decay rates. However, IVR is inhomogeneous and anisotropic. Apical and basal wall segments untwist at different times and rates, transmural strain and strain-rates differ due to the helically variable pitch of myocytes and s... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5564784 Fri, 30 Dec 2011 05:00:00 +0100 5564784 http://www.medworm.com/index.php?rid=5564783&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22210749%26dopt%3DAbstract Authors: Xu A, Vanhoutte PM Abstract The heart and blood vessels are surrounded by epicardial and perivascular adipose tissues respectively, which play important roles in maintaining cardiovascular homeostasis by secreting a number of biologically active molecules, termed "adipokines". Many of these adipokines function as an important component of the 'adipo-cardiovascular axis' mediating the cross-talk between adipose tissues, the heart, and the vasculature. On the one hand, most adipokines [including tumor necrosis factor α, resistin, adipocyte fatty acid binding protein (A-FABP) and lipocalin-2] are pro-inflammatory and causally associated with endothelial and cardiac dysfunction by their endocrine/paracrine actions. On the other hand, adiponectin is one of the few adipokines t... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5564783 Fri, 30 Dec 2011 05:00:00 +0100 5564783 http://www.medworm.com/index.php?rid=5564782&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22210750%26dopt%3DAbstract The objective of this study is to quantify the regional curvatures and area strain (AS) based on three-dimensional (3D) reconstructions of the RV using cardiac magnetic resonance imaging (MRI). Fourteen (14) rTOF patients and nine (9) normal subjects underwent cardiac MRI scan. 3D RV endocardial surface models were reconstructed from manually delineated contours and correspondence between end-diastole (ED) and end-systole (ES) was determined. Regional curvedness (C) and surface area at end-diastole and end-systole were calculated as well as the area strain. The RV shape and deformation in rTOF patients differed from normal subjects in several respects. Firstly, the curvedness at ED (mean for 13 segments, 0.030±0.0076 mm(-1) vs. 0.029±0.0065 mm(-1) , p < 0.05) and ES (mean for 13 segme... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5564782 Fri, 30 Dec 2011 05:00:00 +0100 5564782 http://www.medworm.com/index.php?rid=5564781&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22210751%26dopt%3DAbstract Authors: Inoue N, Kinugawa S, Suga T, Yokota T, Hirabayashi K, Kuroda S, Okita K, Tsutsui H Abstract Angiotensin II (Ang II)-induced oxidative stress has been known to be involved in the pathogenesis of cardiovascular diseases. We have reported that the oxidative stress in skeletal muscle can limit exercise capacity in mice. We thus hypothesized that Ang II could impair the skeletal muscle energy metabolism and limit exercise capacity via enhancing oxidative stress. Ang II (50 ng/kg/min) or vehicle was infused into male C57BL/6J mice for 7 days via subcutaneously implanted osmotic minipumps. Ang II did not alter body weight, skeletal muscle weight, blood pressure, cardiac structure and function. Mice were treadmill-tested and expired gases were analyzed. The work to exhaustion (ver... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5564781 Fri, 30 Dec 2011 05:00:00 +0100 5564781 http://www.medworm.com/index.php?rid=5537109&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F12%252F18%252019.36%2522%255BMHDA%255D%253A%25222011%252F12%252F24%252017.24%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F12%252F18%252019.36%2522%255BEDAT%255D%29%29 53 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/12/24PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5537109 Sat, 24 Dec 2011 22:24:01 +0100 5537109 http://www.medworm.com/index.php?rid=5514955&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F11%252F19%252017.06%2522%255BMHDA%255D%253A%25222011%252F12%252F18%252019.36%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F11%252F19%252017.06%2522%255BEDAT%255D%29%29 90 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/12/18PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5514955 Mon, 19 Dec 2011 00:36:01 +0100 5514955 http://www.medworm.com/index.php?rid=5426007&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F11%252F07%252013.55%2522%255BMHDA%255D%253A%25222011%252F11%252F19%252017.06%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F11%252F07%252013.55%2522%255BEDAT%255D%29%29 28 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/11/19PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5426007 Sat, 19 Nov 2011 22:06:03 +0100 5426007 http://www.medworm.com/index.php?rid=5382513&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F10%252F25%252021.44%2522%255BMHDA%255D%253A%25222011%252F11%252F07%252013.55%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F10%252F25%252021.44%2522%255BEDAT%255D%29%29 73 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/11/07PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5382513 Mon, 07 Nov 2011 18:55:01 +0100 5382513 http://www.medworm.com/index.php?rid=5346690&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F10%252F04%252022.34%2522%255BMHDA%255D%253A%25222011%252F10%252F25%252021.44%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F10%252F04%252022.34%2522%255BEDAT%255D%29%29 29 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/10/25PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5346690 Wed, 26 Oct 2011 01:44:54 +0100 5346690 http://www.medworm.com/index.php?rid=5282869&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F09%252F24%252009.48%2522%255BMHDA%255D%253A%25222011%252F10%252F04%252022.34%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F09%252F24%252009.48%2522%255BEDAT%255D%29%29 112 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/10/04PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5282869 Wed, 05 Oct 2011 02:34:54 +0100 5282869 http://www.medworm.com/index.php?rid=5179883&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F08%252F26%252014.12%2522%255BMHDA%255D%253A%25222011%252F09%252F01%252012.16%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F08%252F26%252014.12%2522%255BEDAT%255D%29%29 37 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/09/01PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5179883 Thu, 01 Sep 2011 16:16:02 +0100 5179883 http://www.medworm.com/index.php?rid=5160061&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F08%252F20%252003.30%2522%255BMHDA%255D%253A%25222011%252F08%252F26%252014.12%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F08%252F20%252003.30%2522%255BEDAT%255D%29%29 65 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/08/26PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5160061 Fri, 26 Aug 2011 18:12:02 +0100 5160061 http://www.medworm.com/index.php?rid=5108178&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F07%252F26%252011.45%2522%255BMHDA%255D%253A%25222011%252F08%252F09%252018.30%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F07%252F26%252011.45%2522%255BEDAT%255D%29%29 16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/08/09PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5108178 Tue, 09 Aug 2011 22:30:02 +0100 5108178 http://www.medworm.com/index.php?rid=5063580&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F07%252F11%252020.15%2522%255BMHDA%255D%253A%25222011%252F07%252F26%252011.45%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F07%252F11%252020.15%2522%255BEDAT%255D%29%29 18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/07/26PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5063580 Tue, 26 Jul 2011 15:45:02 +0100 5063580 http://www.medworm.com/index.php?rid=5011812&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F06%252F26%252015.00%2522%255BMHDA%255D%253A%25222011%252F07%252F11%252020.15%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F06%252F26%252015.00%2522%255BEDAT%255D%29%29 63 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/07/11PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=5011812 Tue, 12 Jul 2011 00:15:02 +0100 5011812 http://www.medworm.com/index.php?rid=4968094&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F06%252F12%252006.30%2522%255BMHDA%255D%253A%25222011%252F06%252F26%252015.00%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F06%252F12%252006.30%2522%255BEDAT%255D%29%29 75 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/06/26PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4968094 Sun, 26 Jun 2011 19:00:03 +0100 4968094 http://www.medworm.com/index.php?rid=4922175&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F05%252F29%252002.30%2522%255BMHDA%255D%253A%25222011%252F06%252F12%252006.30%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F05%252F29%252002.30%2522%255BEDAT%255D%29%29 25 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/06/12PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4922175 Sun, 12 Jun 2011 10:30:02 +0100 4922175 http://www.medworm.com/index.php?rid=4876204&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F05%252F14%252013.45%2522%255BMHDA%255D%253A%25222011%252F05%252F29%252002.30%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F05%252F14%252013.45%2522%255BEDAT%255D%29%29 74 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/05/29PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4876204 Sun, 29 May 2011 06:30:03 +0100 4876204 http://www.medworm.com/index.php?rid=4822046&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F04%252F30%252013.00%2522%255BMHDA%255D%253A%25222011%252F05%252F14%252013.45%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F04%252F30%252013.00%2522%255BEDAT%255D%29%29 20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/05/14PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4822046 Sat, 14 May 2011 17:45:02 +0100 4822046 http://www.medworm.com/index.php?rid=4768407&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21515668%26dopt%3DAbstract EXERCISE-MEDIATED CHANGES IN CONDUIT ARTERY WALL THICKNESS IN HUMANS: ROLE OF SHEAR STRESS. Am J Physiol Heart Circ Physiol. 2011 Apr 22; Authors: Thijssen DH, Dawson EA, van de Munckhof I, Tinken TM, Den Drijver E, Hopkins N, Cable NT, Green DJ Episodic increases in shear stress have been proposed as a mechanism which induces training-induced adaptation in arterial wall remodeling in humans. To address this hypothesis in humans, we examined bilateral brachial artery wall thickness using high-resolution ultrasound in healthy men across an 8-week period of bilateral handgrip training. Unilaterally, shear rate was attenuated by cuff inflation to 60 mmHg. Grip strength, forearm volume and girth improved similarly between the limbs. Acute bouts of handgrip exercise increased shear ... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4768407 Thu, 21 Apr 2011 23:00:00 +0100 4768407 http://www.medworm.com/index.php?rid=4768406&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21515669%26dopt%3DAbstract Authors: Bussey CT, Kolka CM, Rattigan S, Richards SM Recent studies have shown that adiponectin is able to increase nitric oxide (NO) production by the endothelium and relax pre-constricted isolated aortic rings, suggesting that adiponectin may act as a vasodilator. Endothelin-1 (ET-1) is a potent vasoconstrictor, elevated levels of which are associated with obesity, type 2 diabetes, hypertension and cardiovascular disease. We hypothesised that adiponectin has NO-dependent vascular actions opposing the vasoconstrictor actions of ET-1. We studied the vascular and metabolic effects of a physiological concentration of adiponectin (6.5μg.mL(-1)) on Hooded Wistar rats in the constant-flow pump-perfused rat hindlimb. Adiponectin alone had no observable vascular activity; however, adiponect... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4768406 Thu, 21 Apr 2011 23:00:00 +0100 4768406 http://www.medworm.com/index.php?rid=4716487&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F03%252F31%252022.45%2522%255BMHDA%255D%253A%25222011%252F04%252F15%252017.30%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F03%252F31%252022.45%2522%255BEDAT%255D%29%29 20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/04/15PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4716487 Fri, 15 Apr 2011 21:30:02 +0100 4716487 http://www.medworm.com/index.php?rid=4662236&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F03%252F17%252011.00%2522%255BMHDA%255D%253A%25222011%252F03%252F31%252022.45%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F03%252F17%252011.00%2522%255BEDAT%255D%29%29 19 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/03/31PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4662236 Fri, 01 Apr 2011 02:45:02 +0100 4662236 http://www.medworm.com/index.php?rid=4601182&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F03%252F03%252003.45%2522%255BMHDA%255D%253A%25222011%252F03%252F17%252011.00%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F03%252F03%252003.45%2522%255BEDAT%255D%29%29 51 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/03/17PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4601182 Thu, 17 Mar 2011 15:00:03 +0100 4601182 http://www.medworm.com/index.php?rid=4540792&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F02%252F17%252002.15%2522%255BMHDA%255D%253A%25222011%252F03%252F03%252003.45%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F02%252F17%252002.15%2522%255BEDAT%255D%29%29 30 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/03/03PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4540792 Thu, 03 Mar 2011 08:45:03 +0100 4540792 http://www.medworm.com/index.php?rid=4483635&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F01%252F31%252006.00%2522%255BMHDA%255D%253A%25222011%252F02%252F17%252002.15%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F01%252F31%252006.00%2522%255BEDAT%255D%29%29 73 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/02/17PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4483635 Thu, 17 Feb 2011 07:15:03 +0100 4483635 http://www.medworm.com/index.php?rid=4415091&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222011%252F01%252F16%252012.45%2522%255BMHDA%255D%253A%25222011%252F01%252F31%252006.00%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F01%252F16%252012.45%2522%255BEDAT%255D%29%29 24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/01/31PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4415091 Mon, 31 Jan 2011 11:00:03 +0100 4415091 http://www.medworm.com/index.php?rid=4353453&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F12%252F24%252001.10%2522%255BMHDA%255D%253A%25222011%252F01%252F16%252012.45%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F12%252F24%252001.10%2522%255BEDAT%255D%29%29 75 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2011/01/16PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4353453 Sun, 16 Jan 2011 17:45:02 +0100 4353453 http://www.medworm.com/index.php?rid=4285378&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F12%252F14%252011.40%2522%255BMHDA%255D%253A%25222010%252F12%252F24%252001.10%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F12%252F14%252011.40%2522%255BEDAT%255D%29%29 21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/12/24PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4285378 Fri, 24 Dec 2010 06:10:02 +0100 4285378 http://www.medworm.com/index.php?rid=4256880&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F12%252F03%252004.25%2522%255BMHDA%255D%253A%25222010%252F12%252F14%252011.40%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F12%252F03%252004.25%2522%255BEDAT%255D%29%29 100 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/12/14PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4256880 Tue, 14 Dec 2010 16:40:11 +0100 4256880 http://www.medworm.com/index.php?rid=4204670&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21097662%26dopt%3DAbstract Authors: Martin CA, Grace AA, Huang CL Ventricular tachycardia (VT) in Brugada Syndrome (BrS) patients often originates in the right ventricular outflow tract (RVOT). We explore the physiological basis for this observation using murine whole-heart preparations. Ventricular bipolar electrograms and monophasic action potentials were recorded from 7 epicardial positions in Langendorff-perfused WT and Scn5a(+/-) hearts. VT first appeared in the RVOT, implicating it as an arrhythmogenic focus in Scn5a(+/-) hearts. RVOTs showed the greatest heterogeneity in refractory periods, activation latencies and action potential (AP) durations, and the most fractionated electrograms. However, incidences of concordant alternans in dynamic pacing protocol recordings were unaffected by the Scn5a(+/-) muta... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4204670 Fri, 19 Nov 2010 00:00:00 +0100 4204670 http://www.medworm.com/index.php?rid=4204669&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21097663%26dopt%3DAbstract Authors: Tripovic D, Pianova S, McLachlan EM, Brock JA We have investigated the recovery of sympathetic control following reinnervation of denervated rat tail arteries by relating the reappearance of noradrenergic terminals to the amplitude of nerve-evoked contractions of isometrically mounted artery segments in vitro. We have also assessed reactivity to vasoconstrictor agonists. Freezing the collector nerves near the base of the tail in adult rats denervated the artery from ~40 mm along the tail. Restoration of the perivascular plexus declined along the length of the tail, remaining incomplete for >6 months. After 4 months, nerve-evoked contractions were of comparable amplitude to control at ~60 mm along the tail, but smaller at ~110 mm, and were prolonged. At ~60 mm, facilitation ... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4204669 Fri, 19 Nov 2010 00:00:00 +0100 4204669 http://www.medworm.com/index.php?rid=4172345&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F11%252F07%252011.45%2522%255BMHDA%255D%253A%25222010%252F11%252F16%252019.55%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F11%252F07%252011.45%2522%255BEDAT%255D%29%29 21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/11/16PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4172345 Wed, 17 Nov 2010 00:55:04 +0100 4172345 http://www.medworm.com/index.php?rid=4014420&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F09%252F11%252013.03%2522%255BMHDA%255D%253A%25222010%252F09%252F30%252008.55%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F09%252F11%252013.03%2522%255BEDAT%255D%29%29 85 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/09/30PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=4014420 Thu, 30 Sep 2010 12:55:02 +0100 4014420 http://www.medworm.com/index.php?rid=3958480&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F08%252F26%252012.42%2522%255BMHDA%255D%253A%25222010%252F09%252F11%252013.03%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F08%252F26%252012.42%2522%255BEDAT%255D%29%29 58 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/09/11PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3958480 Sat, 11 Sep 2010 17:03:02 +0100 3958480 http://www.medworm.com/index.php?rid=3873530&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20709859%26dopt%3DAbstract Authors: Methner C, Schmidt K, Cohen MV, Downey JM, Krieg T Pre- and postconditioning depend on activation of adenosine receptors at the end of the index ischemia. The aim of this study was to determine which receptor subtypes must be activated. In situ mouse hearts underwent 30 min of regional ischemia followed by 2 h of reperfusion. As expected, either ischemic postconditioning (six cycles of 10 sec of reperfusion and 10 sec of coronary occlusion) or infusion of the selective A(2b) adenosine receptor (A(2b)AR) agonist BAY60-6583 (BAY60) for 60 min starting 5 min prior to reperfusion reduced infarct size in wild-type C57Bl/6N mice. Protection from either was abolished by the selective A(2b)AR antagonist MRS1754 confirming a role for A(2b)AR. Additionally, co-administration of ischemic... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3873530 Thu, 12 Aug 2010 23:00:00 +0100 3873530 http://www.medworm.com/index.php?rid=3873529&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20709860%26dopt%3DAbstract In conclusion, the present simulation study uses the new formulated model of lidocaine, which considers pH and frequency-modulation, and sheds light into the mechanisms by which lidocaine facilitates the onset of reentries, and brings understanding also of the potential antifibrillatory effects of the drug. PMID: 20709860 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3873529 Thu, 12 Aug 2010 23:00:00 +0100 3873529 http://www.medworm.com/index.php?rid=3873528&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20709861%26dopt%3DAbstract Authors: Goldman E Inspiratory fall in arterial blood pressure (Pa) during airway obstruction was ascribed to ventricular interdependence, afterload, and transmission of intrathoracic pressure swings. We have shown this effect significantly reduced in the elderly, but the underlying reasons remain unclear. Here we compare the results of inspiratory loading in young and older subjects with a mathematical model that simulated beat-by-beat fluctuations in cardiopulmonary variables. By increasing arterial and left ventricular elastance parameters in the older group, simulations strongly correlated with the experimental Pa and identified a linear increase of left ventricular transmural pressures with negative intrathoracic pressure that was nearly 38% larger than in the younger group. The a... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3873528 Thu, 12 Aug 2010 23:00:00 +0100 3873528 http://www.medworm.com/index.php?rid=3873527&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20709862%26dopt%3DAbstract Authors: Khandelwal AR, Hebert VY, Dugas TR Resveratrol, a red wine polyphenol, is known to exhibit vascular-protective effects and reduce vascular smooth muscle cell mitogenesis. Vascular smooth muscle cell proliferation is a critical factor in the pathogenesis of restenosis, the re-narrowing of vessels that often occurs after angioplasty and/or stent implantation. Though resveratrol has been shown to be an estrogen receptor (ER) modulator, the role of the ER in resveratrol-mediated protection against restenosis has not yet been elucidated in vivo. Therefore, using a mouse carotid artery injury model, our objective was to determine the role of ER-alpha in modulating resveratrol-mediated effects on neointimal hyperplasia. Female wild-type and estrogen receptor-alpha (-/-) mice were adm... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3873527 Thu, 12 Aug 2010 23:00:00 +0100 3873527 http://www.medworm.com/index.php?rid=3873526&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20709863%26dopt%3DAbstract In conclusion, unlike other established models of cardiomyopathy, disrupting AC(V) expression in the G(alphaq) mouse model is insufficient to overcome several parallel pathophysiological processes leading to progressive heart failure. PMID: 20709863 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3873526 Thu, 12 Aug 2010 23:00:00 +0100 3873526 http://www.medworm.com/index.php?rid=3873525&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20709864%26dopt%3DAbstract Authors: Yalcin HC, Shekhar A, Nishimura N, Rane AA, Schaffer CB, Butcher JT Embryonic heart formation is driven by complex feedback between genetic and hemodynamic stimuli. Clinical congenital heart defects (CHD), however, often manifest as localized micro-tissue malformations with no underlying genetic mutation - suggesting altered hemodynamics during embryonic development may play a role. Investigation of this relationship has been impaired by a lack of experimental tools that can create locally targeted cardiac perturbations. Here, we have developed noninvasive optical techniques which can modulate avian cardiogenesis to dissect relationships between alterations in mechanical signaling and CHD. We used two-photon excited fluorescence (2PEF) microscopy to monitor cushion and ventric... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3873525 Thu, 12 Aug 2010 23:00:00 +0100 3873525 http://www.medworm.com/index.php?rid=3873524&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20709865%26dopt%3DAbstract Authors: Neo BH, Kandhi S, Wolin MS We have previously provided evidence that hydrogen peroxide (H(2)O(2)) stimulates soluble guanylate cyclase under conditions where it relaxes isolated endothelium-removed bovine pulmonary arteries (BPA). Since it was recently reported that H(2)O(2) induces coronary vasorelaxation associated with a NO/cGMP-independent thiol oxidation/subunit dimerization-elicited activation of protein kinase G (PKG), we investigated if this mechanism participates in the relaxation of BPA to H(2)O(2). BPA precontracted with serotonin (incubated under hypoxia to lower endogenous H(2)O(2)) were exposed to increasing concentrations of H(2)O(2). It was observed that 0.1-1 mM H(2)O(2) caused increased PKG dimerization and relaxation. These responses were associated with inc... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3873524 Thu, 12 Aug 2010 23:00:00 +0100 3873524 http://www.medworm.com/index.php?rid=3873523&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20709866%26dopt%3DAbstract Conclusion: Acipimox caused minor changes in whole body metabolism and decreased FFA supply, but a long-term reduction in circulating FFA with acipimox did not change systolic or diastolic cardiac function or exercise capacity in patients with HF. PMID: 20709866 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3873523 Thu, 12 Aug 2010 23:00:00 +0100 3873523 http://www.medworm.com/index.php?rid=3873522&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20709867%26dopt%3DAbstract Authors: Decker KF, Rudy Y Increased incidence of arrhythmia in the healing phase post-infarction has been linked to remodeling in the epicardial border zone (EBZ). Ionic models of normal zone (NZ) and EBZ myocytes were incorporated into one-dimensional models of propagation to gain mechanistic insight into how ion channel remodeling affects AP duration (APD) and refractoriness, vulnerability to conduction block and conduction safety post-infarction. We find that EBZ tissue exhibits abnormal APD restitution. Remodeled I(Na) and I(CaL) promote increased ERP and prolonged APD at short diastolic interval (DI). While post-repolarization refractoriness (PRR) due to remodeled EBZ I(Na) is the primary determinant of the vulnerable window (VW) for conduction block at the NZ to EBZ transition i... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3873522 Thu, 12 Aug 2010 23:00:00 +0100 3873522 http://www.medworm.com/index.php?rid=3873521&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20709868%26dopt%3DAbstract CONCLUSION: We demonstrate for the first time that inhibition of the TNF/Akt/HIF-1 axis prevents vascular remodeling. TNF inhibitors may therefore represent new and interesting therapeutic tools against VRD. PMID: 20709868 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3873521 Thu, 12 Aug 2010 23:00:00 +0100 3873521 http://www.medworm.com/index.php?rid=3806509&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20671291%26dopt%3DAbstract In conclusion, these results demonstrate that cardiac OTRs are involved in the regulation of cardiac function of OVX SHRs. The decreases of OTRs may contribute to cardiac pathology following menopause. PMID: 20671291 [PubMed - in process] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3806509 Sat, 31 Jul 2010 23:00:00 +0100 3806509 http://www.medworm.com/index.php?rid=3767900&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20639216%26dopt%3DAbstract Authors: Charles SM, Zhang L, Cipolla MJ, Buchholz JN, Pearce WJ In light of evidence that immature arteries contain a higher proportion of non-contractile smooth muscle cells than found in fully differentiated mature arteries, the present study explores the hypothesis that age-related differences in smooth muscle phenotype contribute to age-related differences in contractility. Because Ca(2+) handling differs markedly between contractile and non-contractile smooth muscle, the present studies specifically test the hypothesis that the relative contributions of calcium influx and myofilament sensitization to myogenic tone are upregulated, whereas Ca(2+) release is downregulated, in immature (P14) compared to mature (6-month-old) rat middle cerebral arteries (MCA). Myofilament Ca(2+) sens... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3767900 Thu, 15 Jul 2010 23:00:00 +0100 3767900 http://www.medworm.com/index.php?rid=3767899&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20639217%26dopt%3DAbstract This study clearly indicates that cyclic stretch is a strong, direct trigger to induce hypertrophy in fully differentiated rabbit cardiomyocytes. The present findings do not support the notion that stretch-mediated hypertrophy of adult rabbit cardiomyocytes involves autocrine/paracrine actions of AngII, TGFbeta1 or IGF-I. PMID: 20639217 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3767899 Thu, 15 Jul 2010 23:00:00 +0100 3767899 http://www.medworm.com/index.php?rid=3767898&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20639218%26dopt%3DAbstract Conclusion: The anti-inflammatory cytokine IL-10 prevents impairment in endothelium- dependent vasorelaxation caused by TNF-alpha by preserving eNOS expression. PMID: 20639218 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3767898 Thu, 15 Jul 2010 23:00:00 +0100 3767898 http://www.medworm.com/index.php?rid=3767897&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20639219%26dopt%3DAbstract In conclusion, although time to-FMD(max) does not appear to be a useful adjunctive measure of endothelial health, the use of continuous diameter measurements provides important data in the study of endothelial function in healthy subjects and patients with cardiovascular disease. PMID: 20639219 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3767897 Thu, 15 Jul 2010 23:00:00 +0100 3767897 http://www.medworm.com/index.php?rid=3767896&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20639220%26dopt%3DAbstract Authors: Badejo AM, Nossaman VE, Pankey EA, Bhartiya M, Kannadka CB, Murthy SN, Nossaman BD, Kadowitz PJ Bay 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). Responses to iv injections of BAY 41-8543 were investigated under baseline and elevated tone conditions, and when NO synthase (NOS) was inhibited with L-NAME. Under baseline conditions, iv injections of BAY 41-8543 caused small decreases in pulmonary arterial pressure, larger decreases in systemic arterial pressure, and increases in cardiac output. When pulmonary arterial pressure was increased to approximately 30 mm Hg with an iv infusion of U46619, iv injections of BAY 41-8543 produced larger dose-dependent decreases in pulmonary arterial pressure, and the relative decreases in pulmonary a... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3767896 Thu, 15 Jul 2010 23:00:00 +0100 3767896 http://www.medworm.com/index.php?rid=3767895&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20639221%26dopt%3DAbstract Authors: Gergs U, Baumann M, Böckler A, Buchwalow IB, Ebelt H, Fabritz L, Hauptmann S, Keller N, Kirchhof P, Klockner U, Pönicke K, Rueckschloss U, Schmitz W, Werner F, Neumann J Serotonin (5-HT) exerts pleiotropic effects in the human cardiovascular system. Some of the effects are thought to be mediated via 5-HT(4)-receptors, which are expressed in the human atrium and in ventricular tissue. However, a true animal model to study these receptors in more detail is hitherto lacking. Therefore, we generated for the first time a transgenic mouse (TG) with cardiac myocyte specific expression of the human 5-HT(4)-receptor. RT-PCR and immunohistochemistry revealed expression of the receptor on mRNA and protein level. Stimulation of isolated cardiac preparations by isoproterenol increase... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3767895 Thu, 15 Jul 2010 23:00:00 +0100 3767895 http://www.medworm.com/index.php?rid=3767892&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20639222%26dopt%3DAbstract UPREGULATION OF NOX1 IN VASCULAR SMOOTH MUSCLE LEADS TO IMPAIRED ENDOTHELIUM-DEPENDENT RELAXATION VIA ENOS UNCOUPLING. Am J Physiol Heart Circ Physiol. 2010 Jul 16; Authors: Dikalova AE, Gongora MC, Harrison DG, Lambeth JD, Dikalov S, Griendling KK Recent work has made it clear that oxidant systems interact. To investigate potential cross-talk between Nox1 upregulation in vascular smooth muscle and endothelial function, transgenic mice overexpressing Nox1 in smooth muscle cells (Tg(SMCnox1)) were subjected to angiotensin II (Ang II)-induced hypertension. As expected, NADPH-dependent superoxide generation was increased in aortas from Nox1 overexpressing mice. Infusion of Ang II (0.7 mg/kg per day) for 2 weeks potentiated NADPH-dependent superoxide generation and hydrogen peroxid... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3767892 Thu, 15 Jul 2010 23:00:00 +0100 3767892 http://www.medworm.com/index.php?rid=3737532&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F07%252F01%252000.36%2522%255BMHDA%255D%253A%25222010%252F07%252F09%252010.03%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F07%252F01%252000.36%2522%255BEDAT%255D%29%29 40 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/07/09PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3737532 Fri, 09 Jul 2010 14:03:02 +0100 3737532 http://www.medworm.com/index.php?rid=3696026&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F06%252F22%252014.21%2522%255BMHDA%255D%253A%25222010%252F06%252F25%252009.30%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F06%252F22%252014.21%2522%255BEDAT%255D%29%29 64 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/06/25PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3696026 Fri, 25 Jun 2010 13:30:03 +0100 3696026 http://www.medworm.com/index.php?rid=3677448&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F06%252F10%252011.48%2522%255BMHDA%255D%253A%25222010%252F06%252F19%252019.12%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F06%252F10%252011.48%2522%255BEDAT%255D%29%29 16 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/06/19PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3677448 Sat, 19 Jun 2010 23:12:12 +0100 3677448 http://www.medworm.com/index.php?rid=3648356&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20525873%26dopt%3DAbstract Authors: Li J, Rosenblatt-Velin N, Loukili N, Pacher P, Feihl F, Waeber B, Liaudet L Acute myocardial dysfunction is a typical manifestation of septic shock. Experimentally, the administration of endotoxin (lipopolysacharride, LPS) to laboratory animals is frequently used to study such dysfunction. However, a majority of studies used load-dependent indices of cardiac function (including ejection fraction, EF, and maximal systolic pressure increment, dp/dt max), which do not directly explore cardiac inotropism. Therefore, we evaluated the direct effects of LPS on myocardial contractility, using left ventricular (LV) pressure-volume catheters in mice. Male BALB/c mice received an intraperitoneal injection of E. Coli LPS (1, 5, 10, or 20 mg/kg). After 2, 6 or 20 h, cardiac function was an... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3648356 Thu, 03 Jun 2010 23:00:00 +0100 3648356 http://www.medworm.com/index.php?rid=3648355&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20525874%26dopt%3DAbstract Authors: Bondarenko VE, Rasmusson RL Mouse hearts have a diversity of action potentials (APs) generated by the cardiac myocytes from different regions. Recent evidence shows that cells from the epicardial and endocardial regions of the mouse ventricle have diversity in calcium handling properties as well as potassium current expression. In order to examine mechanisms of AP generation, propagation, and stability in transmurally heterogeneous tissue we developed a comprehensive model of the mouse cardiac cells from the epicardial and endocardial regions of the heart. Our computer model simulates the following differences between epicardial and endocardial myocytes: 1) action potential duration is longer in endocardial and shorter in epicardial myocytes; 2) diastolic and systolic [Ca(2+)]... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3648355 Thu, 03 Jun 2010 23:00:00 +0100 3648355 http://www.medworm.com/index.php?rid=3648354&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20525875%26dopt%3DAbstract In conclusion, IPC protects WT mice against in vivo myocardial IR injury regardless of gender and ischemic duration, but, deletion of eNOS abolishes the cardioprotective effect of classical IPC. PMID: 20525875 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3648354 Thu, 03 Jun 2010 23:00:00 +0100 3648354 http://www.medworm.com/index.php?rid=3648353&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20525876%26dopt%3DAbstract Authors: Alloatti G, Arnoletti E, Bassino E, Penna C, Perrelli MG, Ghé C, Muccioli G Obestatin, a newly discovered peptide encoded by the ghrelin gene, induces expression of genes regulating pancreatic beta-cell differentiation, insulin biosynthesis and glucose metabolism. It also activates anti-apoptotic signalling pathways such as PI3K and ERK1/2 in pancreatic beta-cells and human islets. Since these kinases have been shown to protect against myocardial injury, we sought to investigate whether obestatin would exert cardioprotective effects. Both isolated perfused rat heart and cultured cardiomyocyte models of ischemia/reperfusion (I/R) were used, measuring infarct size and cell apoptosis as end points of injury. The presence of specific obestatin receptors on cardiac cells, as wel... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3648353 Thu, 03 Jun 2010 23:00:00 +0100 3648353 http://www.medworm.com/index.php?rid=3648352&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20525877%26dopt%3DAbstract FUNCTIONAL ANATOMY OF THE MURINE SINUS NODE: HIGH-RESOLUTION OPTICAL MAPPING OF ANKYRIN-B HETEROZYGOUS MICE. Am J Physiol Heart Circ Physiol. 2010 Jun 4; Authors: Glukhov AV, Fedorov VV, Anderson ME, Mohler PJ, Efimov IR The mouse is widely used as the genetic platform for investigating the molecular mechanisms of sinoatrial node (SAN) pacemaking. Recently, it was shown that isolated SAN cells from the ankyrin-B deficient mice displayed severe pacemaking dysfunction similar to individuals harboring the ANK2 allele variants. However, these results have been limited to isolated SAN cells only and thus did not evaluate the functional anatomy of the widely distributed atrial pacemaker complex. We studied pacemaker function in an intact mouse atrial preparation, which included the S... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3648352 Thu, 03 Jun 2010 23:00:00 +0100 3648352 http://www.medworm.com/index.php?rid=3618490&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20511406%26dopt%3DAbstract Authors: Berthiaume JM, Bray MS, McElfresh TA, Chen X, Azam SM, Young ME, Hoit BD, Chandler MP Impaired myocardial contractile function is a hallmark of heart failure (HF) which may present under resting conditions and/or during physiological stress. Previous studies reported that high fat feeding in mild-moderate heart failure/LV dysfunction is associated with improved contractile function at baseline. The goal of this study was to determine whether myocardial function is compromised in response to physiological stress and to evaluate the global gene expression profile of rats fed high dietary fat following infarction. Male Wistar rats underwent ligation or sham surgery and fed normal (10% kcal fat) (SHAM+NC, HF+NC) or high fat (60% kcal saturated fat) (SHAM+SAT, HF+SAT) for 8 weeks. ... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3618490 Thu, 27 May 2010 23:00:00 +0100 3618490 http://www.medworm.com/index.php?rid=3618489&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20511407%26dopt%3DAbstract Authors: Brewster LM, Taherzadeh Z, Volger S, Clark JF, Rolf T, Wolf H, van Bavel E, van Montfrans GA Black women are at greater risk to develop hypertension during pregnancy, with a 4.5 times higher rate of fatal preeclampsia as compared to white women. Therefore, it is important to identify factors that may affect this risk. Our group previously proposed that high activity of the central regulatory enzyme of energy metabolism, creatine kinase (CK), may increase ATP buffer capacity and lead to enhanced vascular contractility and reduced NO bioavailability. Therefore, we assessed microvascular contractility characteristics in isolated resistance arteries from self-defined black and white normotensive pregnant women, using a Mulvany-Halpern myograph. Additionally, morphology was assesse... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3618489 Thu, 27 May 2010 23:00:00 +0100 3618489 http://www.medworm.com/index.php?rid=3618488&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20511408%26dopt%3DAbstract Authors: Widlansky ME n/a. PMID: 20511408 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3618488 Thu, 27 May 2010 23:00:00 +0100 3618488 http://www.medworm.com/index.php?rid=3618487&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20511409%26dopt%3DAbstract Central neuronal activation and pressor responses induced by circulating angiotensin II. Role of brain aldosterone-"ouabain" pathway. Am J Physiol Heart Circ Physiol. 2010 May 28; Authors: Huang BS, Ahmadi S, Ahmad M, White RA, Leenen FH An increase in plasma Ang II causes neuronal activation in hypothalamic nuclei and a slow pressor response presumably by increasing sympathetic drive. We evaluated whether activation of a neuromodulatory pathway, involving aldosterone-"ouabain", is involved in these responses. In Wistar rats, subcutaneous infusion of Ang II at 150 and 500 ng/kg/min gradually increased blood pressure up to 60 mmHg at the highest dose. Ang II at 500 ng/kg/min increased plasma Ang II by 4 fold, plasma aldosterone 20 fold and hypothalamic aldosterone 3 fold. Intrac... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3618487 Thu, 27 May 2010 23:00:00 +0100 3618487 http://www.medworm.com/index.php?rid=3618486&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20511410%26dopt%3DAbstract Authors: Lohmeier TE, Iliescu R, Dwyer TM, Irwin E, Cates AW, Rossing MA Following sinoaortic denervation, which eliminates arterial baroreceptor input into the brain, there are slowly developing adaptations that abolish initial sympathetic activation and hypertension. In comparison, electrical stimulation of the carotid sinus for one week produces sustained reductions in sympathetic activity and arterial pressure. However, whether compensations occur subsequently to diminish these responses is unclear. Therefore, we determined whether there are important central and/or peripheral adaptations that diminish the sympathoinhibitory and blood pressure lowering effects of more sustained carotid sinus stimulation. To this end, we measured whole body plasma norepinephrine spillover and alpha-... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3618486 Thu, 27 May 2010 23:00:00 +0100 3618486 http://www.medworm.com/index.php?rid=3618485&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20511411%26dopt%3DAbstract Authors: Yoshikawa Y, Zhang GX, Obata K, Matsuyoshi H, Asada K, Taniguchi S, Takaki M We have previously shown that a newly developed calpain inhibitor, SNJ-1945 (SNJ) with good aqueous solubility prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin as a cardioplegia. The aim of the present study was to investigate certain actions of this calpain inhibitor, SNJ on left ventricular (LV) mechanical work and energetics in the cross-circulated excised rat hearts underwent blood perfusion with 40 muM SNJ. Mean end-systolic pressure at midrange LV volume (ESP(mLVV)) and systolic pressure-volume area (PVA) at mLVV (PVA(mLVV): a total mechanical energy per beat) were significantly increased b... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3618485 Thu, 27 May 2010 23:00:00 +0100 3618485 http://www.medworm.com/index.php?rid=3618484&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20511412%26dopt%3DAbstract Authors: Sprague RS, Goldman DG, Bowles EA, Achilleus D, Stephenson AH, Ellis CG, Ellsworth ML Erythrocytes release both O(2) and a vasodilator, ATP, when exposed to reduced O(2) tension. We investigated the hypothesis that ATP release is impaired in erythrocytes of humans with type 2 diabetes (DM2) and that this defect compromises the ability of these cells to stimulate dilation of resistance vessels. We also determined if a general vasodilator, the prostacyclin analog, iloprost (ILO), stimulates ATP release from healthy human (HH) and DM2 erythrocytes. Finally, we used a computational model to compare the effect on tissue O(2) levels of increases in blood flow directed to areas of increased O(2) demand (erythrocyte ATP release) with non-directed increases in flow (ILO). HH erythrocyt... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3618484 Thu, 27 May 2010 23:00:00 +0100 3618484 http://www.medworm.com/index.php?rid=3618483&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20511413%26dopt%3DAbstract Conclusion: Concomitant increases in iNOS and arginase expression result in unchanged NO species and protein S-nitrosylation; with substrate limitation, uncoupled iNOS produces superoxide anions and contributes to contractile dysfunction. PMID: 20511413 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3618483 Thu, 27 May 2010 23:00:00 +0100 3618483 http://www.medworm.com/index.php?rid=3618482&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20511414%26dopt%3DAbstract Authors: Padilla J, Newcomer SC, Simmons GH, Kreutzer KV, Laughlin MH While the beneficial effects of exercise training on conduit artery endothelial function are well established in animals and humans with compromised basal function, whether or not exercise exerts favorable effects on a healthy endothelium is inconclusive. We sought to determine whether long-term exercise training enhances endothelial function in peripheral conduit arteries of healthy pigs. Using a retrospective analysis of data collected in our laboratory (n=127), we compared in-vitro brachial and femoral artery endothelium-dependent and independent relaxation between a group of pigs that exercise-trained for 16-20 weeks and a group that remained sedentary. No differences in vasomotor function were found between the ... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3618482 Thu, 27 May 2010 23:00:00 +0100 3618482 http://www.medworm.com/index.php?rid=3618481&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20511415%26dopt%3DAbstract Authors: Telinius N, Drewsen N, Pilegaard H, Deleval M, Aalkjaer C, Hjortdal VE, Boedtkjer DM The current study characterizes the mechanical properties of the human thoracic duct and demonstrates a role for adrenoceptors, thromboxane and endothelin receptors in human lymph vessel function. With ethical permission and informed consent, portions of the thoracic duct (2-5cm) were resected and retrieved at T7-T9 during esophageal and cardia cancer surgery. Ring segments (2mm long) were mounted in a myograph for isometric tension (Newton/meter) measurement. The diameter-tension relationship was established using ducts from 10 individuals. Peak active tension of 6.24+/-0.75N/m was observed with a corresponding passive tension of 3.11+/-0.67N/m and average internal diameter of 2.21mm. The equ... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3618481 Thu, 27 May 2010 23:00:00 +0100 3618481 http://www.medworm.com/index.php?rid=3618480&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20511416%26dopt%3DAbstract Conclusion: Our results demonstrate that elevated circulating TGF-ss1 cause endothelial dysfunction through NADPH oxidase activation-induced oxidative stress accelerating atherosclerosis and hypertension in apoE(-/-) mice. These findings may provide a mechanism explaining accelerated atherosclerosis in patients with elevated plasma TGF-beta(1). PMID: 20511416 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3618480 Thu, 27 May 2010 23:00:00 +0100 3618480 http://www.medworm.com/index.php?rid=3586297&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F05%252F18%252012.09%2522%255BMHDA%255D%253A%25222010%252F05%252F21%252018.06%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F05%252F18%252012.09%2522%255BEDAT%255D%29%29 37 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/05/21PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3586297 Fri, 21 May 2010 22:06:02 +0100 3586297 http://www.medworm.com/index.php?rid=3574042&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20472757%26dopt%3DAbstract In conclusion, the endothelium should be the focus of special care in situations of acute limitation of physical activity. PMID: 20472757 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3574042 Thu, 13 May 2010 23:00:00 +0100 3574042 http://www.medworm.com/index.php?rid=3574041&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20472758%26dopt%3DAbstract In this study, we demonstrated that XIAP is recruited into the integrin alpha5 complex via caveolin-1 binding, and mediates cell adhesion. We also determined that XIAP is critical to shear stress-stimulated extracellular signal-regulated kinase (ERK) activation in an integrin alpha5-dependent manner, but is not important to VEGF-induced ERK activation. This differential activation of ERK is partly attributable to unique localizations of the receptors. Furthermore, we confirmed that XIAP is an essential molecule in the efficient recruitment of focal adhesion kinase (FAK) into the integrin alpha5-associated complex. This integrin alpha5-caveolin-1-XIAP-FAK multicomplex regulates endothelial cell migration via a mechanism that involves shear-dependent ERK activation. Together, our results ind... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3574041 Thu, 13 May 2010 23:00:00 +0100 3574041 http://www.medworm.com/index.php?rid=3574040&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20472759%26dopt%3DAbstract This study demonstrates that despite restoration of mechanical function, disturbances in electrical conduction - in and of itself - can cause acute increases in regional in vivo MMP activation, and therefore, contribute to myocardial remodeling. PMID: 20472759 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3574040 Thu, 13 May 2010 23:00:00 +0100 3574040 http://www.medworm.com/index.php?rid=3574039&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20472760%26dopt%3DAbstract Authors: Mkonyi LE, Bletsa A, Fristad I, Wiig H, Berggreen E Gingiva is frequently challenged by oral bacterial products leading to inflammatory responses such as increased fluid filtration and edema formation. The role of initial lymphatics for transcapillary fluid balance in gingiva is unknown and was therefore investigated in genetically engineered K14-VEGFR-3-Ig (K14) lymphedema mice. The mutant mice demonstrated a total lack of lymphatics in gingiva, whereas lymphatics were found in the submucosal parts of alveolar mucosa although almost completely absent in mucosa. In wild-type (WT) mice, lymphatic vessels were detected in mucosal and submucosal part of alveolar mucosa. Interstitial fluid pressure (P(if)) measured with micropipettes was increased in gingiva of K14 mice in the nor... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3574039 Thu, 13 May 2010 23:00:00 +0100 3574039 http://www.medworm.com/index.php?rid=3574038&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20472761%26dopt%3DAbstract Authors: Conover CA, Mason MA, Bale LK, Harrington SC, Nyegaard M, Oxvig C, Overgaard MT Pregnancy-associated plasma protein-A (PAPP-A) increases local insulin-like growth factor (IGF)-I bioavailability through cleavage of inhibitory IGF binding protein (IGFBP)-4 in a variety of systems, including the cardiovascular system. To test the hypothesis that expression of PAPP-A promotes the development of atherosclerotic lesions, we generated transgenic mice that express human PAPP-A in arterial smooth muscle. Four founder lines were characterized for transgenic human PAPP-A mRNA and protein expression, IGFBP-4 protease activity, and tissue specificity. In Study I, apolipoprotein E knock-out (ApoE KO) mice, a well characterized mouse model of atherosclerosis, and ApoE KO mice expressing the ... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3574038 Thu, 13 May 2010 23:00:00 +0100 3574038 http://www.medworm.com/index.php?rid=3574037&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20472762%26dopt%3DAbstract Authors: Hasko G, Pacher P N/A. PMID: 20472762 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3574037 Thu, 13 May 2010 23:00:00 +0100 3574037 http://www.medworm.com/index.php?rid=3574036&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20472763%26dopt%3DAbstract Conclusion RhoA has an important role in the regulation of vascular reactivity after hemorrhagic shock. The Rho kinase-myosin light chain phosphatase and Rac1-PAK-myosin light chain kinase signal pathways participate in the regulatory process of RhoA. Rho kinase-myosin light chain phosphatase may be the main signaling pathway by which RhoA regulates vascular reactivity. PMID: 20472763 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3574036 Thu, 13 May 2010 23:00:00 +0100 3574036 http://www.medworm.com/index.php?rid=3574035&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20472764%26dopt%3DAbstract Authors: López B, González A, Hermida N, Valencia F, de Teresa E, Diez J Due to its dynamic nature, the composition and structure of the myocardial collagen network can be reversibly modified to adapt to transient cardiac injuries. In response to persistent injury however, irreversible, maladaptive changes of the network occur leading to fibrosis mostly characterized by the excessive interstitial and perivascular deposition of collagen types I and III fibers. It is now becoming apparent that myocardial fibrosis directly contributes to adverse myocardial remodeling and the resulting alterations of left ventricular (LV) anatomy and function present in the major types of cardiac diseases. The enzyme lysyl oxidase (LOX) is a cupper-dependent extracellular enzyme that catalyzes lysine... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3574035 Thu, 13 May 2010 23:00:00 +0100 3574035 http://www.medworm.com/index.php?rid=3549865&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20453101%26dopt%3DAbstract Authors: Zhang YL, Tavakoli H, Chachisvilis M We have studied hypoxia induced dynamic changes in the balance between PKA (protein kinase A) and its counteracting phosphatases in micro fluidic environment in single cells using picosecond fluorescence spectroscopy and intramolecular fluorescence resonance energy transfer (FRET) based sensor of PKA activity. (i) We have found that the apparent PKA activity in bone cells (MC3T3-E1) and in endothelial cells (BAEC) is rapidly and sensitively modulated by level of oxygen in the media. When oxygen concentration in the glucose containing media is lowered due to oxygen consumption by the cells in the micro fluidic chamber, the apparent PKA activity increases; reoxygenation of cells under hypoxia leads to rapid (~2 min) decrease of apparent PKA a... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3549865 Thu, 06 May 2010 23:00:00 +0100 3549865 http://www.medworm.com/index.php?rid=3549864&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20453102%26dopt%3DAbstract Authors: Farrell SR, Ross JL, Howlett SE Components of cardiac excitation-contraction (EC)-coupling were compared in ventricular myocytes isolated from 3-month-old male and female rats. Calcium concentrations (fura-2) and cell shortening (edge-detector) were measured simultaneously at 37 degrees C. Membrane potential and ionic currents were measured with microelectrodes. Action potentials were similar in male and female myocytes, but contractions were smaller and slower in females. In voltage-clamped cells, peak contractions were smaller in females than males (5.1 +/- 0.7 vs. 7.7 +/- 0.8 % diastolic length; p<0.05). Similarly, calcium transients were smaller in females than in males and the rate of rise of the calcium transient was slower in females. Despite smaller contractions and... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3549864 Thu, 06 May 2010 23:00:00 +0100 3549864 http://www.medworm.com/index.php?rid=3487492&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20400684%26dopt%3DAbstract Authors: Kalogeris TJ, Korthuis RJ n/a. PMID: 20400684 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3487492 Thu, 15 Apr 2010 23:00:00 +0100 3487492 http://www.medworm.com/index.php?rid=3487491&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20400685%26dopt%3DAbstract In conclusion, allergic A(1)WT mice showed altered vascular reactivity, increased airway responsiveness and systemic inflammation. These data suggest that A(1) AR is pro-inflammatory systemically in this model of asthma. PMID: 20400685 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3487491 Thu, 15 Apr 2010 23:00:00 +0100 3487491 http://www.medworm.com/index.php?rid=3487490&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20400686%26dopt%3DAbstract Authors: Gross GJ, Baker JE, Hsu A, Wu HE, Falck JR, Nithipatikom K We previously demonstrated that 11,12 and 14,15-epoxyeicosatrienoic acids (EETs) produce reductions in myocardial infarct size. Since a recent study demonstrated the release of opioids, in mediating the antinociceptive effect of 14,15-EET, we hypothesized that endogenous opioids may also be involved in mediating the cardioprotective effect of the EETs. To test this hypothesis, we used an in vivo rat model of infarction and a rat Langendorff model. In the infarct model, hearts were subjected to 30-min occlusion of left coronary artery and 2-hr reperfusion. Animals were treated with 11,12-EET or 14,15-EET (2.5 mg/kg) alone 15 min prior to occlusion or with opioid antagonists (naloxone, naltrindole, nor-BNI, and CTOP, a n... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3487490 Thu, 15 Apr 2010 23:00:00 +0100 3487490 http://www.medworm.com/index.php?rid=3487489&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20400687%26dopt%3DAbstract TRANSIENT STIFFENING OF MITRAL VALVE LEAFLETS IN THE BEATING HEART. Am J Physiol Heart Circ Physiol. 2010 Apr 16; Authors: Krishnamurthy G, Itoh A, Swanson JC, Miller DC, Ingels NB Anterior mitral leaflet stiffness during isovolumic contraction (IVC) is much greater than that during isovolumic relaxation (IVR). We have hypothesized that this stiffening is due to transient early-systolic force development in the slip of cardiac myocytes in the annular third of the anterior leaflet. Because the atrium is excited before IVC and leaflet myocytes contract for </=250msec, this hypothesis predicts that IVC leaflet stiffness will drop to near-IVR values in the latter half of ventricular systole. We tested this prediction using radiopaque markers and inverse finite element analysis o... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3487489 Thu, 15 Apr 2010 23:00:00 +0100 3487489 http://www.medworm.com/index.php?rid=3487488&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20400688%26dopt%3DAbstract Authors: Hassona MD, Abouelnaga ZA, Elnakish MT, Awad MM, Alhaj M, Goldschmidt-Clermont PJ, Hassanain HH Increased mechanical stress/hypertension in the vessel wall triggers the hypertrophic signaling pathway, resulting in structural remodeling of vasculature. Vascular hypertrophy of resistance vessels leads to reduced compliance and elevation of blood pressure. We showed before that increased expression of profilin1 protein in the medial layer of the aorta induces stress fiber formation, triggering the hypertrophic signaling resulting in vascular hypertrophy and, ultimately, hypertension in older mice. Our hypothesis is that profilin1 induced vascular hypertrophy in resistance vessels, which led to elevation of blood pressure, and both of which contributed to the modulation of vascula... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3487488 Thu, 15 Apr 2010 23:00:00 +0100 3487488 http://www.medworm.com/index.php?rid=3487487&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20400689%26dopt%3DAbstract Authors: Cui J, Leuenberger UA, Blaha C, Yoder J, Gao Z, Sinoway LI The role adenosine plays in evoking the exercise pressor reflex in humans remains controversial. We hypothesized that localized forearm adenosine receptor blockade would attenuate muscle sympathetic nerve activity (MSNA) responses to fatiguing handgrip exercise in humans. Blood pressure (Finometer), heart rate, and MSNA from peroneal nerve were assessed in 11 healthy young volunteers during fatiguing isometric handgrip, post-exercise circulatory occlusion (PECO), and passive muscle stretch during PECO. The protocol was performed before and after adenosine receptor blockade by local infusion of 40 mg aminophylline in saline via forearm Bier block (regional intravenous anesthesia). In the second experiment, the same amou... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3487487 Thu, 15 Apr 2010 23:00:00 +0100 3487487 http://www.medworm.com/index.php?rid=3487486&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20400690%26dopt%3DAbstract Authors: Keldermann RH, Nash MP, Gelderblom H, Wang VY, Panfilov AV We introduce an integrative 3D electro-mechanical model of the left ventricle (LV) of the human heart. Electrical activity is represented by the ionic TP06 model for human cardiac cells, mechanical activity is represented by the NHS active contractile tension model and the exponential Guccione passive elasticity model. These models are embedded into an anatomical model of the LV that contains a detailed description of cardiac geometry and fiber orientation field. We demonstrate that fiber shortening and wall thickening during normal excitation were qualitatively similar to experimental recordings. We used this model to study the effect of mechano-electrical feedback via the stretch-activated channels on the stability o... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3487486 Thu, 15 Apr 2010 23:00:00 +0100 3487486 http://www.medworm.com/index.php?rid=3468605&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F04%252F07%252013.26%2522%255BMHDA%255D%253A%25222010%252F04%252F15%252001.34%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F04%252F07%252013.26%2522%255BEDAT%255D%29%29 35 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/04/15PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3468605 Thu, 15 Apr 2010 05:34:02 +0100 3468605 http://www.medworm.com/index.php?rid=3444050&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F04%252F03%252019.28%2522%255BMHDA%255D%253A%25222010%252F04%252F07%252013.26%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F04%252F03%252019.28%2522%255BEDAT%255D%29%29 17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/04/07PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3444050 Wed, 07 Apr 2010 17:26:02 +0100 3444050 http://www.medworm.com/index.php?rid=3435516&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F03%252F31%252002.02%2522%255BMHDA%255D%253A%25222010%252F04%252F03%252019.28%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F03%252F31%252002.02%2522%255BEDAT%255D%29%29 43 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/04/03PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3435516 Sat, 03 Apr 2010 23:28:07 +0100 3435516 http://www.medworm.com/index.php?rid=3395449&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304811%26dopt%3DAbstract Authors: Police SB, Putnam K, Thatcher SE, Batifoulier-Yiannikouris F, Daugherty A, Cassis LA Previous studies demonstrated that obesity increases inflammation in periaortic adipose tissue and promotes angiotensin II (AngII)-induced AAAs. We sought to determine if weight loss of obese C57BL/6 mice would influence the progression of established AAAs. Male C57BL/6 mice were fed a high fat diet (HF) for 4 months, and then infused with either saline or AngII (1,000 ng/kg/min) for 3 months. Mice with dilated suprarenal aortas at 28 days of AngII infusion were designated to groups fed the HF (HF/HF) or a low fat diet (LF, 10% kcal as fat; HF/LF) to induce weight loss for the last 2 months of infusions. Suprarenal aortic lumen diameters of obese mice were increased by AngII infusion at day 28... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3395449 Fri, 19 Mar 2010 00:00:00 +0100 3395449 http://www.medworm.com/index.php?rid=3395448&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304812%26dopt%3DAbstract Authors: Bunker AK, Arce-Esquivel AA, Rector RS, Booth FW, Ibdah JA, Laughlin MH We tested the hypothesis that physical activity can attenuate the temporal decline of acetylcholine-induced endothelium dependent relaxation during type 2 diabetes mellitus progression in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. OLETF sedentary rats exhibited decreased acetylcholine-induced abdominal aortic endothelium dependent relaxation from 13 weeks of age (wk) to 20wk (20-35%) and from 13wk to 40wk (35-50%). Acetylcholine-induced endothelium dependent relaxation was maintained in the OLETF physically active and the control sedentary Long-Evans Tokushima Otsuka (LETO) groups from 13wk to 40wk. Aortic pre-treatment with N(G)-nitro-L-arginine (LN), indomethacin (INDO), and LN+INDO did not alter... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3395448 Fri, 19 Mar 2010 00:00:00 +0100 3395448 http://www.medworm.com/index.php?rid=3395447&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304813%26dopt%3DAbstract This study examines the roles of BPA Nox oxidases and mitochondria in the HPV response. Inhibitors of Nox2 (0.1mM apocynin and 50muM gp91-dstat) and mitochondrial electron transport (10muM antimycin and rotenone) decreased superoxide generation in BPA without affecting contraction to 25mM KCl or the HPV response. Transfection of BPA with siRNA for Nox2 and Nox4 decreased Nox2 and Nox4 protein expression, respectively, associated with an attenuation of superoxide detection, without affecting 25mM KCl contraction. However, Nox4 siRNA, but, not Nox2 attenuated HPV in BPA. A Nox4 inhibitor plumbagin (10muM) increased basal force, decreased superoxide detection and peroxide release, and caused BPA to relax under hypoxia. While acute removal of peroxide with 0.1mM ebselen increased 25mM KCl cont... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3395447 Fri, 19 Mar 2010 00:00:00 +0100 3395447 http://www.medworm.com/index.php?rid=3395446&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304814%26dopt%3DAbstract Authors: Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S Endothelin-1 (ET-1) shows a positive inotropic effect on cardiac muscle. Although the L-type Ca(2+) current (ICa) is one of the important determinants of cardiac excitation-contraction coupling, the effect of ET-1 on the ICa is not always clear. The controversial results appear to be due to different patch clamp methods. The present study measured the effect of ET-1 on the ICa of rat ventricular myocytes using the perforated patch clamp technique. The holding potential was set -40 mV and depolarization was applied every 10 s. ET-1 (10 nM) increased the ICa in a monophasic manner. The current reached a steady state 15 min after the application of ET-1, when the measurement was done. Endothelin receptor s... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3395446 Fri, 19 Mar 2010 00:00:00 +0100 3395446 http://www.medworm.com/index.php?rid=3395445&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304815%26dopt%3DAbstract Authors: Miller JD, Peotta VA, Chu Y, Weiss RM, Zimmerman KA, Brooks RM, Heistad DD Endothelial function is impaired by oxidative stress in chronic heart failure (HF). Mechanisms that protect against increases in oxidative stress in HF are not clear. The goal of this study was to determine whether manganese superoxide dismutase (MnSOD) plays a key role in protecting against endothelial dysfunction in HF. Endothelial function and gene expression were examined in aorta from wild-type mice (MnSOD(+/+)) and mice deficient in manganese superoxide dismutase (MnSOD(+/-)) 12 weeks after ligation of the left coronary artery (LCA). LCA ligation produced similar size myocardial infarctions in MnSOD(+/+) and MnSOD(+/-) mice, and reduced ejection fraction to ~20% in both groups. Maximal relaxation ... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3395445 Fri, 19 Mar 2010 00:00:00 +0100 3395445 http://www.medworm.com/index.php?rid=3395444&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304816%26dopt%3DAbstract This study compared basal localization, import and export of NFATc1 and NFATc3 in adult atrial and ventricular myocytes to identify isoform- and tissue-specific regulatory mechanisms of NFAT activation under physiological conditions and in heart failure. NFAT-GFP fusion proteins and NFAT immunocytochemistry were used to analyze NFAT regulation in adult cat and rabbit myocytes. NFATc1 displayed basal nuclear localization in atrial and ventricular myocytes, an effect that was reversed by reducing [Ca(2+)]i and inhibiting CaN, and enhanced by inhibition of nuclear export. In contrast NFATc3 was localized to the cytoplasm, but could be driven to the nucleus by angiotensin II and endothelin-1 stimulation in atrial, but not ventricular cells. Inhibition of nuclear export (by Leptomycin B) facili... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3395444 Fri, 19 Mar 2010 00:00:00 +0100 3395444 http://www.medworm.com/index.php?rid=3395443&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304817%26dopt%3DAbstract Authors: Gioda CR, de Oliveira Barreto T, Gomes TN, de Lima D, Campos PP, Capettini LS, Lauton-Santos S, Vasconcelos A, Coimbra CC, Lemos VS, Pesquero JL, Cruz JS Thiamine is an important cofactor of metabolic enzymes, and its deficiency leads to cardiovascular dysfunction. Firstly we characterized the metabolic status measuring resting oxygen consumption rate and lactate blood concentration after 35 days of thiamine deficiency. The results pointed to a decrease in resting oxygen consumption and a two-fold increase in blood lactate. Confocal microscopy showed that intracellular superoxide (approximately 40%) and H2O2 (2.5 times) contents had been increased. In addition, biochemical activities and protein expression of superoxide-dismutase, glutathione-peroxidase and catalase were evalu... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3395443 Fri, 19 Mar 2010 00:00:00 +0100 3395443 http://www.medworm.com/index.php?rid=3395442&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304818%26dopt%3DAbstract Authors: Rengo G, Leosco D, Zincarelli C, Marchese M, Corbi G, Liccardo D, Filippelli A, Ferrara N, Lisanti MP, Koch WJ, Lymperopoulos A Exercise training has been reported to exert beneficial effects on cardiac function and to reduce morbidity and mortality of chronic heart failure (HF). Augmented sympathetic nervous system (SNS) activity, leading to elevated circulating catecholamine (CA) levels, is a hallmark of chronic HF that significantly aggravates this disease. Exercise training has been shown to also reduce SNS overactivity in HF but the underlying molecular mechanism(s) remain unidentified. We recently reported that adrenal G-protein coupled receptor kinase-2 (GRK2), an enzyme that regulates the sympatho-inhibitory alpha2-adrenoceptors (alpha2-ARs) present in the CA-producing... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3395442 Fri, 19 Mar 2010 00:00:00 +0100 3395442 http://www.medworm.com/index.php?rid=3395441&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304819%26dopt%3DAbstract Authors: Janowski E, Berrios M, Cleemann L, Morad M The dominant mode of intracellular Ca(2+)-release in adult mammalian heart is gated by ryanodine receptors (RyRs), but it is less clear if IP3-gated Ca(2+) release channels (IP3Rs), that are important during embryogenesis, play a significant role during early post-natal development. To address this question, we measured confocal 2-D Ca(2+)-dependent fluorescence images (Fluo-4) in acutely isolated neonatal (day 1-2 ) and juvenile (day 8-10) rat cardiomyocytes, either voltage-clamped or permeabilized, where rapid exchange of solution could be used to selectively activate the two types of Ca(2+) release channel. Targeting RyRs with caffeine produced large and rapid Ca(2+) signals throughout the cells. Application of ATP and endothelin-1... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3395441 Fri, 19 Mar 2010 00:00:00 +0100 3395441 http://www.medworm.com/index.php?rid=3395440&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304820%26dopt%3DAbstract Authors: Carter BD, Feng N, Paolocci N n/a Key words: p75NTR, semaphorins, nerve growth factor, sympathetic fibers. PMID: 20304820 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3395440 Fri, 19 Mar 2010 00:00:00 +0100 3395440 http://www.medworm.com/index.php?rid=3395439&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20304821%26dopt%3DAbstract In conclusion, LV relaxation during IVR is associated with changes in principal strains and untwisting, which are all correlated with an apparent increase in LV volume. Since closed mitral and aortic valves ensure true isovolumic conditions, the apparent volume change likely reflects expansion of the LV myocardium and the inward bowing of the closed mitral leaflets toward the LV interior. Key words: diastolic function, active relaxation, mitral valve leaflets. PMID: 20304821 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3395439 Fri, 19 Mar 2010 00:00:00 +0100 3395439 http://www.medworm.com/index.php?rid=3288433&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F02%252F17%252020.30%2522%255BMHDA%255D%253A%25222010%252F02%252F19%252017.22%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F02%252F17%252020.30%2522%255BEDAT%255D%29%29 36 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/02/19PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3288433 Fri, 19 Feb 2010 22:22:03 +0100 3288433 http://www.medworm.com/index.php?rid=3280556&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F02%252F10%252009.02%2522%255BMHDA%255D%253A%25222010%252F02%252F17%252020.30%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F02%252F10%252009.02%2522%255BEDAT%255D%29%29 62 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/02/17PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3280556 Thu, 18 Feb 2010 01:30:02 +0100 3280556 http://www.medworm.com/index.php?rid=3198154&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20090009%26dopt%3DAbstract Letter to the editor: "Postulated functional advantages of a looped as opposed to a linearly arranged heart". Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H726; author reply H727 Authors: Kilner PJ PMID: 20090009 [PubMed - in process] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3198154 Fri, 22 Jan 2010 22:16:07 +0100 3198154 http://www.medworm.com/index.php?rid=3198153&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20090011%26dopt%3DAbstract Letter to the editor: "Depolarization and repolarization alternans in an anesthetized canine ischemia model". Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H728; author reply H729 Authors: Madias JE PMID: 20090011 [PubMed - in process] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3198153 Fri, 22 Jan 2010 22:16:05 +0100 3198153 http://www.medworm.com/index.php?rid=3149667&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222010%252F01%252F02%252006.32%2522%255BMHDA%255D%253A%25222010%252F01%252F07%252020.12%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222010%252F01%252F02%252006.32%2522%255BEDAT%255D%29%29 35 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2010/01/07PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3149667 Fri, 08 Jan 2010 01:12:02 +0100 3149667 http://www.medworm.com/index.php?rid=3136123&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044439%26dopt%3DAbstract Authors: Hao F, Tan M, Wu DD, Xu X, Cui MZ Lysophosphatidic acid (LPA) is a potent bioactive lysophospholipid. Accumulated evidence supports a role of LPA in inflammation. To profile LPA-induced cytokine production in vascular smooth muscle cells (SMC), we used a cytokine antibody array system and found that LPA prominently induces the secretion of interleukin 6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) from human aortic smooth muscle cells (HASMCs). The mechanism by which LPA induces MCP-1 expression in SMCs has been reported previously. However, LPA induction of IL-6 secretion from vascular SMCs and its regulatory mechanism are unknown. The present study reveals that LPA induces the expression of IL-6 mRNA and protein in HASMC as well as the secretion of IL-6 protein in a... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3136123 Thu, 31 Dec 2009 00:00:00 +0100 3136123 http://www.medworm.com/index.php?rid=3136122&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044440%26dopt%3DAbstract Authors: Borbouse L, Dick GM, Payne GA, Payne BD, Svendsen MC, Neeb ZP, Alloosh M, Bratz IN, Sturek M, Tune JD This investigation was designed to examine the hypothesis that impaired function of coronary microvascular BKCa channels in metabolic syndrome (MetS) significantly attenuates the balance between myocardial oxygen delivery and metabolism at rest and during exercise-induced increases in myocardial oxygen consumption (MVO2). Studies were conducted in conscious, chronically instrumented Ossabaw swine fed a normal maintenance diet (11% kcal from fat) or an excess calorie atherogenic diet (43% kcal from fat, 2% cholesterol, 20% kcal from fructose) that induces many common features of MetS. Data were collected under baseline/resting conditions and during graded treadmill exercise bef... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3136122 Thu, 31 Dec 2009 00:00:00 +0100 3136122 http://www.medworm.com/index.php?rid=3136121&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044441%26dopt%3DAbstract We examined these gas reactions when Hb-containing solutions of four kinds were perfused through artificial narrow tubes at a practical Hb concentration (10 g/dL). Purified Hb solution, polymerized bovine Hb (PolyBHb), encapsulated Hb (Hb-vesicles, HbV, 279 nm), and RBCs were perfused through a gas-permeable narrow tube (25 microm inner diameter) at 1 mm/s centerline velocity. The level of reactions was determined microscopically based on he visible-light absorption spectrum of Hb. When the tube was immersed in NO and CO atmospheres, both NO-binding and CO-binding of deoxygenated Hb and PolyBHb in the tube were faster than those of HbV and RBCs, and HbV and RBCs showed almost identical binding rates. When the tube was immersed in a N2 atmosphere, oxygenated Hb and PolyBHb showed much faste... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3136121 Thu, 31 Dec 2009 00:00:00 +0100 3136121 http://www.medworm.com/index.php?rid=3136120&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044442%26dopt%3DAbstract IMMUNE REGULATION AND VASCULAR INFLAMMATION IN GENETIC HYPERTENSION. Am J Physiol Heart Circ Physiol. 2009 Dec 31; Authors: Viel EC, Lemarié CA, Benkirane K, Paradis P, Schiffrin EL Immune cells have been implicated in the pathogenesis of hypertension. We hypothesized that under the influence of chromosome 2 (chr2), T lymphocytes contribute to vascular inflammation in genetic salt-sensitive hypertension. Normotensive (Brown Norway), hypertensive (Dahl salt-sensitive) and consomic rats (SSBN2, in which chr2 has been transferred from Brown Norway to Dahl rats) were studied. Systolic blood pressure measured by tail-cuff and aortic preproendothelin mRNA measured by RT-qPCR were elevated in Dahl rats compared with Brown Norway rats, and were reduced in SSBN2 compared with Dahl ... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3136120 Thu, 31 Dec 2009 00:00:00 +0100 3136120 http://www.medworm.com/index.php?rid=3136119&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044443%26dopt%3DAbstract This study sought to test the hypothesis that orthostasis-induced cerebral hypoperfusion would be less severe in physically active (ACT) than in sedentary (SED) elderly humans. Peak O2 uptake of 10 SED (67.1+/-1.4 yr) and 9 ACT (68.0+/-1.1 yr) volunteers was determined by a graded cycling exercise test (22.1+/-1.2 vs 35.8+/-1.3 ml/min/kg, P<0.01). Baseline mean arterial pressure (MAP, Tonometry) and middle cerebral arterial blood flow velocity (VMCA, transcranial Doppler) were similar between the groups (SED vs ACT: 91+/-3 vs 87+/-3 mmHg and 54.9+/-2.3 vs 57.8+/-3.2 cm/s, respectively); whereas heart rate was higher and stroke volume (Bio-Impedance) was smaller in SED than in ACT. Central hypovolemia during graded lower body negative pressure (LBNP) was larger (P<0.01) in ACT than in... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3136119 Thu, 31 Dec 2009 00:00:00 +0100 3136119 http://www.medworm.com/index.php?rid=3136118&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20044444%26dopt%3DAbstract Authors: Gao L, Li Y, Schultz HD, Wang WZ, Wang W, Finch M, Smith LM, Zucker IH Elevated central Angiotensin II (Ang II) plays a critical role in the sympatho-excitation of chronic heart failure (CHF) by stimulating up-regulated Angiotensin type 1 receptors (AT1R) in the rostral ventrolateral medulla (RVLM). However, the link between Ang II signaling and electrophysiological characteristics of neurons in the RVLM remains unclear. In the present experiments, we screened for potentially altered genes in the medulla of rats with CHF that are directly related to neuronal membrane conductance using the Rat Genome 230 2.0 Array GeneChip. We found that CHF rats exhibited a 2.1-fold reduction in Kv4.3 gene expression, one of the main voltage-gated K(+) channels, in the medulla. Real-time RT-PC... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3136118 Thu, 31 Dec 2009 00:00:00 +0100 3136118 http://www.medworm.com/index.php?rid=3099518&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008266%26dopt%3DAbstract Authors: Csont T none Key words: nitroglycerin, preconditioning, endothelial dysfunction, nitrate tolerance. PMID: 20008266 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099518 Fri, 11 Dec 2009 00:00:00 +0100 3099518 http://www.medworm.com/index.php?rid=3099517&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008267%26dopt%3DAbstract Authors: Adderley SP, Sridharan M, Bowles EA, Stephenson AH, Ellsworth ML, Sprague RS Activation of the beta-adrenergic receptor (betaAR) or the prostacyclin receptor (IPR) results in increases in cAMP and ATP release from erythrocytes. cAMP levels depend on a balance between synthesis via adenylyl cyclase and hydrolysis by phosphodiesterases (PDEs). Previously we reported that cAMP increases associated with activation of the betaAR and IPR in rabbit and human erythrocytes are tightly regulated by distinct PDEs. Importantly, inhibitors of these PDEs potentiated both increases in cAMP and ATP release. It has been shown that increases in protein kinase (PK) activity can activate PDEs 3 and 4. Both PKA and PKC are present in the erythrocyte and can phosphorylate and activate these PDEs. H... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099517 Fri, 11 Dec 2009 00:00:00 +0100 3099517 http://www.medworm.com/index.php?rid=3099516&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008268%26dopt%3DAbstract Conclusion: Chronic U-II infusion causes diastolic dysfunction, caused by fibrosis of the LV. The in vitro data suggests that this may be in part occurring via a ROCK dependent pathway. Key words: Cardiac Remodeling, Rho Kinase, Fibrosis, Urotensin II. PMID: 20008268 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099516 Fri, 11 Dec 2009 00:00:00 +0100 3099516 http://www.medworm.com/index.php?rid=3099515&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008269%26dopt%3DAbstract We examined the hypothesis that enhanced monocyte/vascular smooth muscle cell (VSMC) interactions leading to subendothelial monocyte retention and differentiation to macrophages under diabetic conditions may be underlying mechanisms. Human aortic VSMCs (HVSMCs) treated with diabetic stimuli high glucose (HG) or S100B, a ligand of the receptor for advanced glycation end products, exhibited significantly increased binding of THP-1 monocytic cells. Diabetic stimuli increased the expression of the adhesive chemokine fractalkaline (FKN) in HVSMCs. Pretreatment of HVSMCs with FKN or monocyte chemoattractant protein-1 (MCP-1) neutralizing antibodies significantly inhibited monocyte-VSMC binding, while monocytes treated with FKN showed enhanced binding to VSMC. Mouse aortic VSMCs (MVSMCs) derived ... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099515 Fri, 11 Dec 2009 00:00:00 +0100 3099515 http://www.medworm.com/index.php?rid=3099514&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008270%26dopt%3DAbstract BAROREFLEX CONTROL OF MUSCLE SYMPATHETIC NERVE ACTIVITY: A NON-PHARMACOLOGICAL MEASURE OF BAROREFLEX SENSITIVITY. Am J Physiol Heart Circ Physiol. 2009 Dec 11; Authors: Hart EC, Joyner MJ, Wallin BG, Karlsson T, Curry TB, Charkoudian N The sensitivity of baroreflex control of sympathetic nerve activity (SNA) represents the responsiveness of SNA to changes in blood pressure. In a slightly different analysis, the baroreflex threshold measures the probability of whether a sympathetic burst will occur at a given diastolic blood pressure. We hypothesized that baroreflex threshold analysis could be used to estimate the sensitivity of the sympathetic baroreflex measured by the pharmacological modified Oxford test. We compared four measures of sympathetic baroreflex sensitivity in 25 y... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099514 Fri, 11 Dec 2009 00:00:00 +0100 3099514 http://www.medworm.com/index.php?rid=3099513&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008271%26dopt%3DAbstract Authors: Wang J, Gao E, Song J, Zhang XQ, Li J, Koch WJ, Tucker AL, Philipson KD, Chan TO, Feldman AM, Cheung JY Phosphorylation at serine(68) of phospholemman (PLM) in response to beta-adrenergic stimulation results in simultaneous inhibition of cardiac Na(+)/Ca(2+) exchanger (NCX1) and relief of inhibition of Na(+)-K(+)-ATPase. The role of PLM in mediating beta-adrenergic effects on in vivo cardiac function was investigated using congenic PLM knockout (KO) mice. Echocardiography showed similar ejection fraction between wild-type (WT) and PLM-KO hearts. Cardiac catheterization demonstrated higher baseline contractility (+dP/dt) but similar relaxation (-dP/dt) in PLM-KO mice. In response to isoproterenol (Iso), maximal +dP/dt was similar but maximal -dP/dt was reduced in PLM-KO mice. T... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099513 Fri, 11 Dec 2009 00:00:00 +0100 3099513 http://www.medworm.com/index.php?rid=3099512&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008272%26dopt%3DAbstract In conclusion, augmentation index is principally determined by aortic reservoir function and other elastic arteries and only to a minor extent by reflected waves. Reservoir function rather than wave reflection changes markedly with aging, which accounts for the age-related changes in the aortic pressure waveform. Key words: arteries, blood pressure, ageing. PMID: 20008272 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099512 Fri, 11 Dec 2009 00:00:00 +0100 3099512 http://www.medworm.com/index.php?rid=3099511&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008273%26dopt%3DAbstract Authors: Waldsee R, Ahnstedt H, Eftekhari S, Edvinsson L Experimental cerebral ischemia and organ culture of cerebral arteries result in the enhanced expression of endothelin ETB receptors in smooth muscle cells via increased transcription. The present study was designed to evaluate the involvement of calcium-calmodulin-dependent protein kinase (CAMK) in the transcriptional expression of endothelin receptors after organ culture. Rat basilar arteries were incubated for 24 hours with or without the CAMK inhibitor KN93 or ERK1/2 inhibitor U0126. The contractile responses to endothelin-1 (ET-1; ETA and ETB receptor agonist) and sarafotoxin 6c (S6c; ETB receptor agonist) were studied using a sensitive myograph. The mRNA levels of the ETA and ETB receptors and CAMKII were determined by real-... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099511 Fri, 11 Dec 2009 00:00:00 +0100 3099511 http://www.medworm.com/index.php?rid=3099510&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008274%26dopt%3DAbstract In conclusion, EP4 knockdown in cardiac myocytes in aged male KO mice is in part associated with increased fibrosis, reduced EF and dilated cardiomyopathy. Early overexpression of GDF-15 in hearts of male KO mice may contribute to or be a marker of the disease phenotype. The absence of serious cardiac dysfunction in aged female mice suggests a sexual dimorphism in the phenotype. Key words: heart, gene array, EP4, remodeling. PMID: 20008274 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099510 Fri, 11 Dec 2009 00:00:00 +0100 3099510 http://www.medworm.com/index.php?rid=3099509&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008275%26dopt%3DAbstract Authors: Huang C, Liu W, Perry CN, Yitzhaki S, Lee Y, Yuan H, Tsukada YT, Hamacher-Brady A, Mentzer RM, Gottlieb RA Previously we showed that sulfaphenazole (SUL), an antimicrobial agent that is a potent inhibitor of cytochrome P4502C9, is protective against ischemia/reperfusion (I/R) injury. The mechanism, however, underlying this cardioprotection, is largely unknown. With evidence that activation of autophagy is protective against simulated I/R in HL-1 cells, and evidence that autophagy is upregulated in preconditioned hearts, we hypothesized that SUL-mediated cardioprotection might resemble ischemic preconditioning with respect to activation of protein kinase C and autophagy. We used the Langendorff model of global ischemia to assess the role of autophagy and protein kinase C in myo... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099509 Fri, 11 Dec 2009 00:00:00 +0100 3099509 http://www.medworm.com/index.php?rid=3099508&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008276%26dopt%3DAbstract Authors: Merkel MJ, Liu L, Cao Z, Packwood WH, Young J, Alkayed NJ, Van Winkle DM Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), primarily 14,15-EET. EETs are derived from arachidonic acid via P450 epoxygenases and are cardioprotective. We tested the hypothesis that sEH deficiency and pharmacological inhibition elicit tolerance to ischemia via EET-mediated STAT3 signaling in vitro and in vivo. In addition, the relevance of single nucleotide polymorphisms (SNPs) of EPHX2 (the gene encoding sEH) on tolerance to oxygen/glucose deprivation and reoxygenation/glucose repletion (OGD/RGR) was assessed in male C57BL\6J (WT) or sEH knockout (sEHKO) cardiomyocytes using TAT mediated transduction with sEH mutant proteins. Cell death and hydrolase activity was lower i... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099508 Fri, 11 Dec 2009 00:00:00 +0100 3099508 http://www.medworm.com/index.php?rid=3099507&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008277%26dopt%3DAbstract Conclusions: The absence of SPARC reduced age-dependent alterations in ECM fibrillar collagen and diastolic function. These data support the hypothesis that SPARC plays a key role in post-synthetic procollagen processing and contributes to the increase in collagen content found in aged myocardium. Key words: Collagen, SPARC, Aging, Diastolic function. PMID: 20008277 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099507 Fri, 11 Dec 2009 00:00:00 +0100 3099507 http://www.medworm.com/index.php?rid=3099506&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20008278%26dopt%3DAbstract This study was designed to examine the effect of Resveratrol (RSV), a potent activator of SIRT1, on cardiac function and SERCA2a expression in chronic type-1 diabetes. Adult male mice were injected with streptozotocin (STZ) and fed with either a regular diet or a diet enriched with RSV. STZ administration produced progressive decline in cardiac function, associated with markedly reduced SERCA2a and SIRT1 protein levels and increased collagen deposition RSV treatment to these mice had a tremendous beneficial effect both in terms of improving SERCA2a expression as well as on cardiac function. In cultured cardiomyocytes RSV restored SERCA2 promoter activity which was otherwise highly repressed in high glucose media. Protective effects of RSV were found dependent on its ability to activate SIR... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3099506 Fri, 11 Dec 2009 00:00:00 +0100 3099506 http://www.medworm.com/index.php?rid=3067946&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222009%252F11%252F28%252001.36%2522%255BMHDA%255D%253A%25222009%252F12%252F09%252004.14%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222009%252F11%252F28%252001.36%2522%255BEDAT%255D%29%29 17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2009/12/09PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3067946 Wed, 09 Dec 2009 09:14:02 +0100 3067946 http://www.medworm.com/index.php?rid=3034598&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222009%252F11%252F18%252019.14%2522%255BMHDA%255D%253A%25222009%252F11%252F28%252001.36%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222009%252F11%252F18%252019.14%2522%255BEDAT%255D%29%29 20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2009/11/28PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=3034598 Sat, 28 Nov 2009 06:36:02 +0100 3034598 http://www.medworm.com/index.php?rid=2985779&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222009%252F11%252F05%252020.00%2522%255BMHDA%255D%253A%25222009%252F11%252F13%252006.02%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222009%252F11%252F05%252020.00%2522%255BEDAT%255D%29%29 63 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2009/11/13PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=2985779 Fri, 13 Nov 2009 11:02:02 +0100 2985779 http://www.medworm.com/index.php?rid=2931405&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222009%252F10%252F22%252002.06%2522%255BMHDA%255D%253A%25222009%252F10%252F27%252015.16%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222009%252F10%252F22%252002.06%2522%255BEDAT%255D%29%29 17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2009/10/27PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=2931405 Tue, 27 Oct 2009 19:16:02 +0100 2931405 http://www.medworm.com/index.php?rid=2880084&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%29%2520AND%2520%25222009%252F10%252F07%252003.22%2522%255BMHDA%255D%253A%25222009%252F10%252F11%252000.16%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%28%2522Am%2520J%2520Physiol%2520Heart%2520Circ%2520Physiol%2522%255BTIAB%255D%29%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222009%252F10%252F07%252003.22%2522%255BEDAT%255D%29%29 43 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Heart Circ Physiol These pubmed results were generated on 2009/10/11PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=2880084 Sun, 11 Oct 2009 04:16:03 +0100 2880084 http://www.medworm.com/index.php?rid=2842994&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783772%26dopt%3DAbstract DEVELOPMENTAL REGULATION OF CARDIOVASCULAR FUNCTION IS DEPENDENT ON BOTH GENOTYPE AND ENVIRONMENT. Am J Physiol Heart Circ Physiol. 2009 Sep 25; Authors: Knight BS, Sunn N, Pennell CE, Adamson SL, Lye SJ Adverse developmental environments can increase the risk of adult cardiovascular disease but not all individuals are affected, suggesting the importance of genotype. Genetically distinct mouse strains allow genetic dissection of complex-traits; however, they have not been utilized to evaluate the developmental origins of adult cardiovascular disease. Our objective was to determine the effect of prenatal nutrient restriction (R) on adult cardiovascular function in A/J (AJ) and C57BL/6J (B6) mice, and whether postnatal high-fat (HF) diet exacerbates these effects. Pregnant AJ and... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=2842994 Thu, 24 Sep 2009 23:00:00 +0100 2842994 http://www.medworm.com/index.php?rid=2842993&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783773%26dopt%3DAbstract In conclusions, PKA-activated-p85alpha integrates cAMP/PKA signaling differently in VSMCs and ECs. By reducing neointimal hyperplasia without inhibiting endothelial regeneration, it exerts a protective effect against restenosis after balloon injury. Key words: Restenosis, smooth muscle cells, endothelial cells, cAMP. PMID: 19783773 [PubMed - as supplied by publisher] (Source: Am J Physiol Heart C...) Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=2842993 Thu, 24 Sep 2009 23:00:00 +0100 2842993 http://www.medworm.com/index.php?rid=2842992&cid=s_29164_7_f&fid=29164&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783774%26dopt%3DAbstract Authors: Ullrich ND, Fanchaouy M, Gusev K, Shirokova N, Niggli E Duchenne muscular dystrophy represents a severe inherited disease of striated muscle. It is caused by a mutation of the dystrophin gene and characterized by a progressive loss of skeletal muscle function. Most patients also develop a dystrophic cardiomyopathy resulting in dilated hypertrophy and heart failure, but cellular mechanisms leading to deterioration of cardiac function remain elusive. Here we tested whether defective excitation-contraction (EC) coupling contributes to impaired cardiac performance. "EC-coupling gain" was determined in cardiomyocytes from control and dystrophin-deficient mdx mice. To this end, Ca2+ currents (ICaL) were measured with the whole-cell patch-clamp technique, while Ca(2+) transients were... Am J Physiol Heart C... journals http://www.medworm.com/rss/comments.php?id=2842992 Thu, 24 Sep 2009 23:00:00 +0100 2842992