MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'American Journal of Reproductive Immunology' source. Fri, 19 Mar 2010 13:40:06 +0100 http://www.medworm.com/index.php?rid=3371212&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00823.x Conclusion We propose that subclinical intraamniotic infection may be a cause of postpartum cardiovascular collapse and DIC and resemble AFE. Thus, some patients with the clinical diagnosis of AFE may have infection/systemic inflammation as a mechanism of disease. These observations have implications for the understanding of the mechanisms of disease of patients who develop cardiovascular collapse and DIC, frequently attributed to AFE. It may be possible to identify a subset of patients who have biochemical and immunological evidence of systemic inflammation at the time of admission, and before a catastrophic event occurs. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3371212 Wed, 17 Mar 2010 00:00:00 +0100 3371212 http://www.medworm.com/index.php?rid=3371211&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00811.x Conclusion Women with MIFs or RPLs have increased T cell activation in peripheral blood lymphocytes, and T cell suppressor activation seems to be associated with decreased Th1 immunity. Further studies on T cell activation may elucidate molecular mechanisms controlling Th1 effectors. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3371211 Wed, 17 Mar 2010 00:00:00 +0100 3371211 http://www.medworm.com/index.php?rid=3371210&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00824.x Citation Fitzgerald JS, Germeyer A, Huppertz B, Jeschke U, Knöfler M, Moser G, Scholz C, Sonderegger S, Toth B, Markert UR. Governing the invasive trophoblast: current aspects on intra- and extracellular regulation. Am J Reprod Immunol 2010 This review summarizes several aspects especially of regulating factors governing trophoblast invasion. Those include the composition of the extracellular matrix containing a variety of matrix metalloproeinases and their inhibitors, but also intracellular signals. Furthermore, a newly described trophoblast subtype, the endoglandular trophoblast, is presented. Its presence may provide a possible mechanism for opening and connecting uterine glands into the intervillous space. Amongst others, two intracellular signalling pathways are crucial for regulatio... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3371210 Wed, 17 Mar 2010 00:00:00 +0100 3371210 http://www.medworm.com/index.php?rid=3371209&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00825.x Citation Chernyshov VP, Sudoma IO, Dons'koi BV, Kostyuchyk AA, Masliy YV. Elevated NK cell cytotoxicity, CD158a expression in NK cells and activated T lymphocytes in peripheral blood of women with IVF failures. Am J Reprod Immunol 2010Problem The aim of this study was to evaluate the role of elevated natural killer cytotoxicity (NKc) in women with multiple implantation failures (IF) in vitro fertilization[ndash]embryo transfer (IVF[ndash]ET) cycles.Methods of study Seventy-nine antiphospholipid antibodies-negative women with IF including 33 women with elevated NKc were selected for investigation. K-562 cell line was used to evaluate NKc. Lymphocyte subsets, intracellular cytokines [interferon (IFN)-[gamma], interleukin (IL)-4, tumour necrosis factor, IL-10], expression of activating marker... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3371209 Wed, 17 Mar 2010 00:00:00 +0100 3371209 http://www.medworm.com/index.php?rid=3371208&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00826.x Conclusions Combination therapy that includes a heparin may allow successful IVF outcome and this issue merits further study. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3371208 Wed, 17 Mar 2010 00:00:00 +0100 3371208 http://www.medworm.com/index.php?rid=3371207&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00827.x Conclusion It is likely that antithyroglobulin antibodies have no direct detrimental effect on such organs in patients with thyroid autoimmunity suffering from recurrent abortion. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3371207 Wed, 17 Mar 2010 00:00:00 +0100 3371207 http://www.medworm.com/index.php?rid=3355374&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00822.x Citation Mincheva-Nilsson L, Baranov V. The Role of Placental Exosomes in Reproduction. Am J Reprod Immunol 2010 Cell communication comprises cell[ndash]cell contact, soluble mediators and intercellular nanotubes. There is, however, another cell[ndash]cell communication by released membrane-bound microvesicles that convey cell[ndash]cell contact 'by proxy' transporting signals/packages of information from donor to recipient cells locally and/or at a distance. The nanosized exosomes comprise a specialized type of microvesicles generated within multivesicular bodies (MVB) and released upon MVB fusion with the plasma membrane. Exosomes are produced by a variety of immune, epithelial and tumor cells. Upon contact, exosomes transfer molecules that can render new properties and/or reprogram thei... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3355374 Fri, 12 Mar 2010 00:00:00 +0100 3355374 http://www.medworm.com/index.php?rid=3355375&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00821.x This article revises relevant literature on regulatory T cells in human and murine pregnancy. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3355375 Thu, 11 Mar 2010 00:00:00 +0100 3355375 http://www.medworm.com/index.php?rid=3332302&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00815.x Conclusion This study provides the first evidence that HEECs have an ability to phagocytose apoptotic trophoblasts. Furthermore, we demonstrated an inflammatory response of HEECs after phagocytosing the apoptotic trophoblast cells. This event may contribute to the inflammatory response in both normal pregnancy and pathologic pregnancy such as preeclampsia. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3332302 Fri, 05 Mar 2010 00:00:00 +0100 3332302 http://www.medworm.com/index.php?rid=3332303&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00812.x Conclusion IL-17+ cells might be involved in the induction of inflammation in the late stage of abortion, but not in the early stage of abortion. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3332303 Thu, 04 Mar 2010 00:00:00 +0100 3332303 http://www.medworm.com/index.php?rid=3316610&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00820.x Conclusion Our findings indicate that genetic alteration of fetal IDO gene does not appear to be a primary cause of pre-eclampsia. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3316610 Mon, 01 Mar 2010 00:00:00 +0100 3316610 http://www.medworm.com/index.php?rid=3316612&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00816.x Conclusion Our results correlate with previous reports from our laboratory indicating that IFN- [gamma] is deleterious for mouse embryo outgrowth, having an effect on metalloproteinases activity as well as leptin secretion. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3316612 Sun, 28 Feb 2010 00:00:00 +0100 3316612 http://www.medworm.com/index.php?rid=3316611&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00819.x We examined studies on the epidemiology of C. trachomatis infections, the effects infections have on the female reproductive tract and subsequent reproductive health and what measures are being taken to reduce these problems. Undetected or multiple infections in women can lead to the development of severe reproductive sequelae, including pelvic inflammatory disease and tubal infertility. There are two possible paradigms of chlamydial pathogenesis, the cellular and immunological paradigms. While many vaccine candidates are being extensively tested in animal models, they are still years from clinical trials. With no vaccine available and antibiotic treatment unable to halt the increased incidence, infection rates will continue to increase and cause a significant burden on health care systems... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3316611 Sun, 28 Feb 2010 00:00:00 +0100 3316611 http://www.medworm.com/index.php?rid=3284907&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00809.x Conclusion Hyperresistinemia is a feature of acute pyelonephritis during pregnancy. The results of this study support the role of resistin as an acute-phase protein in the presence of bacterial infection during pregnancy. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3284907 Fri, 19 Feb 2010 00:00:00 +0100 3284907 http://www.medworm.com/index.php?rid=3280844&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00818.x Citation Burke SD, Barrette VF, Gravel J, Carter ALI, Hatta K, Zhang J, Chen Z, Leno-Durán E, Bianco J, Leonard S, Murrant C, Adams MA, Anne Croy B. Uterine NK cells, spiral artery modification and the regulation of blood pressure during mouse pregnancy. Am J Reprod Immunol 2010 Reproductive success in mammals involves coordinated changes in the immune and cardiovascular as well as in the neuroendocrine and reproductive systems. This review addresses studies that identify potential links for NK cells and T cells with the local and systemic cardiovascular adaptations of pregnancy. The studies reviewed have utilized immunohistochemisty and in vivo analyses of vascular parameters by ultrasound, chronic monitoring of hemodynamics via radiotelemetric recording and intravital microscopy. At the... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3280844 Thu, 18 Feb 2010 00:00:00 +0100 3280844 http://www.medworm.com/index.php?rid=3280846&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00817.x Conclusion We demonstrate that viral ssRNA induces a pro-inflammatory and type I interferon response in the trophoblast and this inflammatory process may indirectly induce trophoblast apoptosis. These results provide a novel mechanism by which certain viral infections might compromise placental integrity and function, and therefore, pregnancy outcome. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3280846 Wed, 17 Feb 2010 00:00:00 +0100 3280846 http://www.medworm.com/index.php?rid=3280845&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00814.x Conclusion Apo E4 codon 112C point mutation is, by itself, not associated with an elevated risk of recurrent pregnancy loss, but rather codon 112C in association with codon 158C is a risk factor for RPL. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3280845 Wed, 17 Feb 2010 00:00:00 +0100 3280845 http://www.medworm.com/index.php?rid=3276974&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00813.x Citation Nagamatsu T, Schust DJ. The contribution of macrophages to normal and pathological pregnancies. Am J Reprod Immunol 2010 Macrophages represent one of the major leukocyte subsets in the uterine decidua. Owing to their remarkable phenotypic plasticity, decidual macrophages can participate in diverse activities during pregnancy. At baseline, decidual macrophages are characterized by an immunosuppressive phenotype and M2 polarization, supporting feto-maternal immune tolerance. In early pregnancy, macrophage-derived pro-angiogenic factors prompt vascular remodeling within the uterine wall to ensure appropriate utero-placental circulation. Upon invasion by pathogens, pattern recognition receptors on decidual macrophages help to alter the characteristics of these malleable cells toward a... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3276974 Wed, 17 Feb 2010 00:00:00 +0100 3276974 http://www.medworm.com/index.php?rid=3276976&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00800.x Citation Vaisbuch E, Romero R, Erez O, Mazaki-Tovi S, Kusanovic JP, Soto E, Dong Z, Chaiworapongsa T, Kim SK, Ogge G, Pacora P, Yeo L, Hassan SS. Activation of the alternative pathway of complement is a feature of pre-term parturition but not of spontaneous labor at term. Am J Reprod Immunol 2010Problem Plasma concentrations of fragment Bb (FBb) are a marker for activation of the alternative pathway of the complement system. High concentrations of FBb in maternal blood, as early as the first trimester, are associated with subsequent spontaneous pre-term delivery (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3276976 Tue, 16 Feb 2010 00:00:00 +0100 3276976 http://www.medworm.com/index.php?rid=3276975&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00810.x Citation Thaxton JE, Sharma S. Interleukin-10: a multi-faceted agent of pregnancy. Am J Reprod Immunol 2010 It is widely accepted that pregnancy constitutes a unique developmental event. Unprecedented intrauterine actions of angiogenesis, immunity, and neuroendocrine regulation are juxtaposed to mechanisms of senescence that enable fetal growth and protection. The suppressive and regulatory factors that facilitate healthy pregnancy are under investigation. In non-pregnant systems of infection and inflammation, the cytokine interleukin-10 (IL-10) has been widely investigated because of its potential as a key immunosuppressant in response to a multitude of inflammatory events. In the context of pregnancy, IL-10 levels increase markedly in women during early pregnancy and remain elevated well... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3276975 Tue, 16 Feb 2010 00:00:00 +0100 3276975 http://www.medworm.com/index.php?rid=3251724&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00807.x Citation Wang X, Huang C, Sun B, Gu Y, Cui Y, Zhao X, Li Y, Zhang S. The effect of high gravidity on the carcinogenesis of mammary gland in TA2 mice. Am J Reprod Immunol 2010 Spontaneous breast cancer in Tientsin Albinao 2 (TA2) mice, like human pregnancy-associated breast cancer (PABC), often occurs in pregnancy and puerperium, especially in mice with high gravidity. We hypothesized that the dysfunction of cellular immunity caused by the increase of 17[beta]-estradiol (E2) and progesterone (P) might be one of the reasons for carcinogenesis of mammary gland. We investigated the T lymphocyte subsets and the concentration of serum hormone and cytokines in cancer-bearing, pregnant or postpartum TA2 mice using flow cytometry, chemiluminescent immunoassay, and enzyme-linked immunosorbent assay ... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3251724 Tue, 09 Feb 2010 00:00:00 +0100 3251724 http://www.medworm.com/index.php?rid=3251725&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00806.x Conclusion sHLA-G blood serum concentration levels would seem to provide important information regarding the degree of immune system regulation disturbance in both ectopic endometrial cells and the cancer cell suppressive microenvironment. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3251725 Mon, 08 Feb 2010 00:00:00 +0100 3251725 http://www.medworm.com/index.php?rid=3236872&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2010.00808.x Conclusion Determination of the presence and spectra of AEA in patients with endometriosis and TFI undergoing IVF may be a useful marker to predict their pregnancy outcome. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3236872 Thu, 04 Feb 2010 00:00:00 +0100 3236872 http://www.medworm.com/index.php?rid=3236873&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00805.x This study demonstrates that aPL limit trophoblast cell migration by downregulating trophoblast IL-6 secretion and STAT3 activity. As heparin was unable to prevent these effects, our findings may explain why women with antiphospholipid syndrome, treated with heparin, remain at risk of developing obstetrical syndromes, associated with impaired deep placentation, such as pre-eclampsia. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3236873 Wed, 03 Feb 2010 00:00:00 +0100 3236873 http://www.medworm.com/index.php?rid=3186431&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00804.x Conclusion Acute pyelonephritis during pregnancy is associated with a high circulating maternal visfatin concentration. These findings suggest that visfatin/PBEF may play a role in the regulation of the complex and dynamic crosstalk between inflammation and metabolism during pregnancy. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3186431 Wed, 20 Jan 2010 00:00:00 +0100 3186431 http://www.medworm.com/index.php?rid=3186433&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00798.x Conclusion Th1/Th2 cytokine balance and HLA play important roles in the tolerance and maintenance of pregnancy. ICP may be resulting from breach of the maternal fetal immune tolerance during pregnancy. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3186433 Tue, 19 Jan 2010 00:00:00 +0100 3186433 http://www.medworm.com/index.php?rid=3186432&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00803.x Citation Dutsch-Wicherek M. RCAS1, MT, and vimentin as potential markers of tumor microenvironment remodeling. Am J Reprod Immunol 2010 A tumor stimulates the remodeling of its microenvironment for its own survival. To protect its own growth and induce angiogenesis, the tumor changes the structure of extracellular matrix and the function of existing cells; it thus chemo-attracts immune system cells altering their function. In our study, we discuss the potential markers of tumor microenvironment remodeling. For instance, RCAS1 is a protein responsible for tumor escape from host immunologic surveillance that additionally seems to be involved in the remodeling of the microenvironment. Another protein, metallothionein, which is both anti-apoptotic and pro-proliferative, is also responsible for... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3186432 Tue, 19 Jan 2010 00:00:00 +0100 3186432 http://www.medworm.com/index.php?rid=3164866&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00802.x Conclusion We conclude that the fetal monocyte activation and the increase in maternal anti-fetal antigen-specific ASC were related to the incidence and severity of HDCP. These results provide both indirect and direct evidence for the occurrence of exaggerated maternal humoral immunity against the fetal antigens in HDCP. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3164866 Wed, 13 Jan 2010 00:00:00 +0100 3164866 http://www.medworm.com/index.php?rid=3164869&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00797.x Conclusion The data suggest that in Brazilian women polymorphism PTPN22 (C1858T) may be an important genetic predisposing factor for endometriosis, especially, in advanced disease. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3164869 Tue, 12 Jan 2010 00:00:00 +0100 3164869 http://www.medworm.com/index.php?rid=3164868&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00799.x Conclusion Hypertensive disorders in pregnancy were not associated with the LEP, LEPR, and PPAR[gamma]2 polymorphisms studied. The role of other variations in the LEP and PPAR genes in the pathophysiology of PIH and in exacerbations are the objective of ongoing research. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3164868 Tue, 12 Jan 2010 00:00:00 +0100 3164868 http://www.medworm.com/index.php?rid=3164867&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00801.x Conclusion The IFNGR1 gene polymorphisms may contribute to the pathogenesis of pre-eclampsia in our population. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3164867 Tue, 12 Jan 2010 00:00:00 +0100 3164867 http://www.medworm.com/index.php?rid=3160495&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00796.x Conclusion The results show that estradiol leads to limited viral replication and diminished mucosal IgG response, resulting in non-sterile immune protection against genital herpes infection. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3160495 Tue, 12 Jan 2010 00:00:00 +0100 3160495 http://www.medworm.com/index.php?rid=3150047&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00790.x Conclusion In a subgroup of RIF-patients with high level of CD56+ CD16+ NK-cells the additional application of IVIG leads to a favourable pregnancy outcome. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3150047 Fri, 08 Jan 2010 00:00:00 +0100 3150047 http://www.medworm.com/index.php?rid=3143479&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00788.x Conclusion These data suggest that the postpartum period, like pregnancy, is characterized by decreased NK cytotoxicity activity. This suppressed NK cytotoxic effect may result as a response to interaction with tolerized fetal microchimeric cells accumulated during pregnancy in maternal blood and tissues. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3143479 Wed, 06 Jan 2010 00:00:00 +0100 3143479 http://www.medworm.com/index.php?rid=3143482&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00784.x Conclusion There are no differential effects on peripheral immune functions between cyclic and sustained estrogen administration under the same total dose. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3143482 Tue, 05 Jan 2010 00:00:00 +0100 3143482 http://www.medworm.com/index.php?rid=3143481&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00785.x Conclusion The results indicate that both pSG.SS.YL-F[beta].ECD and pSG.SS.C3d3.YL-F[beta].ECD DNA vaccines are effective in birth control of mice. The immunocontraceptive effect of F[beta].ECD DNA vaccine in male mice is improved with the addition of immuno-adjuvant C3d3. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3143481 Tue, 05 Jan 2010 00:00:00 +0100 3143481 http://www.medworm.com/index.php?rid=3143480&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00786.x Conclusions The type of cytokines present in the semen will depend on the single or simultaneous presence of leukocytes and/or pathogens. Chronic male genital tract infections could be associated with the development of anti-HSP-60 antibodies and anti-sperm antibodies. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3143480 Tue, 05 Jan 2010 00:00:00 +0100 3143480 http://www.medworm.com/index.php?rid=3137930&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00793.x Conclusion Our data suggest that paternal antigens are processed early during pregnancy, which leads to the generation of Treg. The continuous release of placental antigens into the maternal circulation allows the maintenance of a Treg population which is specific for paternal antigens and mediates tolerance toward the semi-allogeneic fetus until the time point of birth. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3137930 Mon, 04 Jan 2010 00:00:00 +0100 3137930 http://www.medworm.com/index.php?rid=3137929&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00794.x Citation Manaster I, Mandelboim O. The unique properties of uterine NK cells. Am J Reprod Immunol 2009 Natural killer (NK) cells are lymphocytes of the innate immunity system that are able to kill various hazardous pathogens and tumors. However, it is now widely accepted that NK cells also possess non-destructive functions, as has been demonstrated for uterine NK cells. Here, we review the unique properties of the NK cells in the uterine mucosa, prior to and during pregnancy. We discuss the phenotype and function of mouse and human endometrial and decidual NK cells and suggest that the major function of decidual NK cells is to assist in fetal development. We further discuss the origin of decidual NK cells and suggest several possibilities that might explain their accumulation in the decidu... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3137929 Mon, 04 Jan 2010 00:00:00 +0100 3137929 http://www.medworm.com/index.php?rid=3137928&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00795.x Conclusion Our findings indicate that the TGF-[beta]1 c.869T>C polymorphism may be a genetic risk factor for PE and IUGR-complicated PE. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3137928 Mon, 04 Jan 2010 00:00:00 +0100 3137928 http://www.medworm.com/index.php?rid=3127291&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00789.x Citation Yan L, Zuo C, Wei D, Zhao X. Some severe maternal diseases might be caused by fetal-versus-maternal disease (FVMD). Am J Reprod Immunol 2009 Pregnancy-related disease is a common challenging clinical problem. From our review and clinical experience, we hypothesize that many severe pregnancy-related complications might be caused by a fetal-versus-maternal disease (FVMD), based on the fact that maternal disease is related to immunity and that fetal cells are present in maternal blood. Fetus is a semi-antigen and can be considered as a tumor or graft. The pathophysiology of FVMD must be complex. We speculate it to be a three-step process: impaired maternal immunological function, fetal T-cell activation and injury of target organs. More experiments and research will be needed to prov... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3127291 Wed, 30 Dec 2009 00:00:00 +0100 3127291 http://www.medworm.com/index.php?rid=3127295&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00778.x Conclusion The expression of IL-6, VEGF, and HIF-1[alpha] in trophoblastic cells is involved in the control of trophoblast invasion and migration. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3127295 Tue, 29 Dec 2009 00:00:00 +0100 3127295 http://www.medworm.com/index.php?rid=3127294&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00779.x Conclusion Elevated concentration of leptin in peritoneal fluid may contribute to the pathological process of endometriosis through activation of peritoneal macrophages. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3127294 Tue, 29 Dec 2009 00:00:00 +0100 3127294 http://www.medworm.com/index.php?rid=3127293&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00780.x Conclusion These findings suggest that the GSTP1 exon 5 polymorphism is not a major determinant of the development of advanced stage endometriosis in the Korean population. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3127293 Tue, 29 Dec 2009 00:00:00 +0100 3127293 http://www.medworm.com/index.php?rid=3127292&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00781.x Conclusion An IL-6-mediated endothelium dependent NO-cyclic guanine monophosphate-mediated relaxation pathway may be inhibited in systemic vessels in pre-eclampsia. As observed in this study Glu298Asp eNOS gene polymorphism did not showed significant association with pre-eclampsia. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3127292 Tue, 29 Dec 2009 00:00:00 +0100 3127292 http://www.medworm.com/index.php?rid=3107237&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00775.x Conclusion Our results show that diabetes creates pro-inflammatory environment thus potentially influencing the outcome of pregnancy. We conclude that neutrophil-derived cytokine production could contribute to the complications seen in pregnant women with type 1 diabetes. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3107237 Mon, 21 Dec 2009 00:00:00 +0100 3107237 http://www.medworm.com/index.php?rid=3107239&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00773.x Conclusion SASP reduced rates of pre-term delivery and improved pregnancy outcomes for mice infected with 104 CFU E. coli. This suggests that SASP has the potential to play a role in strategies to prevent pre-term birth in women. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3107239 Sun, 20 Dec 2009 00:00:00 +0100 3107239 http://www.medworm.com/index.php?rid=3107238&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00774.x Conclusion Suppression of pregnancy loss by paternal/embryo Class I MHC depends on the presence of paternal peptides. This greatly complicates existing models of Class I[ndash]KIR interactions in feto-maternal tolerance or rejection. It is important to consider all the data when devising explanatory models. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3107238 Sun, 20 Dec 2009 00:00:00 +0100 3107238 http://www.medworm.com/index.php?rid=3089966&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00772.x Conclusion The results of this study suggest the importance of day 7.5 p.c. for RCAS1 protein expression in connection with placentation as a possible target for future in vivo studies. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3089966 Wed, 16 Dec 2009 00:00:00 +0100 3089966 http://www.medworm.com/index.php?rid=3089969&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00768.x Conclusion Endogenous antimicrobial activity may provide a biomarker of healthy mucosal immunity and may be reduced in the setting of HC. However, larger prospective studies are needed. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3089969 Tue, 15 Dec 2009 00:00:00 +0100 3089969 http://www.medworm.com/index.php?rid=3089968&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00769.x Conclusion There was no association between ectopic pregnancy and [minus]634C/G, [minus]460T/C, and +936C/T VEGF polymorphisms. There was no correlation between VEGF genotype and the expression of VEGF in blood samples. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3089968 Tue, 15 Dec 2009 00:00:00 +0100 3089968 http://www.medworm.com/index.php?rid=3089967&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00771.x Conclusion Th17 levels in peripheral blood lymphocytes do not change during normal pregnancy. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=3089967 Tue, 15 Dec 2009 00:00:00 +0100 3089967 http://www.medworm.com/index.php?rid=2985975&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00766.x Conclusion Maternal hosts generate a normal Listeria-specific adaptive immunity in particular CD8+ T-cell memory response suggesting that systemic listeriosis during pregnancy may be an immunopathology associated with placental infection. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2985975 Fri, 13 Nov 2009 00:00:00 +0100 2985975 http://www.medworm.com/index.php?rid=2985978&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00762.x Conclusion Higher maternal age, postpartum increase in stress perception and low number of leucocytes are associated with a higher incidence of inflammatory breast diseases. Further studies must examine the causality of this effect. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2985978 Thu, 12 Nov 2009 00:00:00 +0100 2985978 http://www.medworm.com/index.php?rid=2985977&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00763.x Conclusion Decreased expression of FOXP3 mRNA and increased expression of T-bet mRNA may contribute to Th1 type immunity predominant in pre-eclampsia. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2985977 Thu, 12 Nov 2009 00:00:00 +0100 2985977 http://www.medworm.com/index.php?rid=2985976&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00764.x Conclusion The study did not reveal menstrual cycle-depended changes in PB NK cells. Thus, a suggestion to measure these cells in a specific phase of the cycle in order to predict the outcome of a subsequent pregnancy in women with fertility problems is objected. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2985976 Thu, 12 Nov 2009 00:00:00 +0100 2985976 http://www.medworm.com/index.php?rid=2978447&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00770.x Conclusion In contrast to the other mutations and polymorphisms, FV Leiden, FXIII V34L, GPIIIa L33P, Apo E, prothrombin G20210A, PAI-1 and MTHFR C677T gene mutations may help to identify the couples at risk for recurrent pregnancy loss. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2978447 Wed, 11 Nov 2009 00:00:00 +0100 2978447 http://www.medworm.com/index.php?rid=2964213&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00761.x Conclusion CD68+CD14+ macrophages present in the stroma of the interplacentomal endometrium and caruncular septa of the placentome are regionally differentiated with regard to expression of CD11b and MHC class II. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2964213 Fri, 06 Nov 2009 00:00:00 +0100 2964213 http://www.medworm.com/index.php?rid=2964212&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00759.x Conclusion Supposed increase in various antiphospholipid antibodies (aPLs) levels due to the stress during the short time of admission and a need for a quick medical decision to terminate the pregnancy was not unambiguously proven, but our results are evidently influenced by the current urgent life-saving treatment. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2964212 Fri, 06 Nov 2009 00:00:00 +0100 2964212 http://www.medworm.com/index.php?rid=2964211&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00757.x Conclusion Our data implicate maternal immunopotentiation to protect the embryo against teratogenic insults, possibly through its effect on the expression of p65, bcl-2 or p53. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2964211 Fri, 06 Nov 2009 00:00:00 +0100 2964211 http://www.medworm.com/index.php?rid=2964210&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00751.x Conclusion Patients with APS have impairment in fibrinolysis evidenced by prolonged CLT at baseline. TAFI and CLT do not seem to be useful as markers of obstetric outcome or risk of thrombosis in patients with APS. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2964210 Fri, 06 Nov 2009 00:00:00 +0100 2964210 http://www.medworm.com/index.php?rid=2964209&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00758.x While considerable information exists regarding the early interactions of spermatozoon and egg that lead to successful fertilization, the molecular biology of events that result in the incorporation of the spermatozoon within the cortical ooplasm is largely undefined. There is circumstantial evidence suggesting that this process involves the interactions of specific oolemmal receptors and their ligands on sperm that bear similarities to mechanisms used in phagocytosis by macrophages. We have postulated that the egg may act as a 'non-professional phagocyte' during its association with the spermatozoon. This review surveys those events, provides an historical context, and creates a paradigm for further investigation. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2964209 Fri, 06 Nov 2009 00:00:00 +0100 2964209 http://www.medworm.com/index.php?rid=2964208&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00760.x Conclusions These findings might suggest that increased production of estradiol and proinflammatory cytokines in the peritoneal cavity possibly leads to the establishment of endometriosis through increased level of GSH. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2964208 Fri, 06 Nov 2009 00:00:00 +0100 2964208 http://www.medworm.com/index.php?rid=2891918&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00746.x (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2891918 Wed, 14 Oct 2009 23:00:00 +0100 2891918 http://www.medworm.com/index.php?rid=2881580&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00756.x Conclusions Our results demonstrate that placental exposure to LTA and LPS appear to trigger distinct cytokine responses that can be modulated by IL-10. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2881580 Sun, 11 Oct 2009 23:00:00 +0100 2881580 http://www.medworm.com/index.php?rid=2881583&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00744.x Conclusion Homozygosity for the D allele of the ACE gene and the combination of the D/D genotype with two 4G alleles of the PAI-1 promoter gene are not associated with a significant increase in the risk of recurrent miscarriage. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2881583 Sat, 10 Oct 2009 23:00:00 +0100 2881583 http://www.medworm.com/index.php?rid=2881582&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00750.x Conclusion Recurrent pregnancy losses and implantation failures have lack of, or negative correlation between NCRs and intracellular cytokines expression. This observation suggests that excessive pro-inflammatory cytokine expression in NK cells in RPL and implantation failures may be exerted through the NCRs or interruption of signal transduction processes. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2881582 Sat, 10 Oct 2009 23:00:00 +0100 2881582 http://www.medworm.com/index.php?rid=2881581&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00753.x Conclusion Association between autoimmune disease and gynecological cancer (or praecancerosis) is major risk than without immunology deviation. Twin A is periodically gynecologically observed. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2881581 Sat, 10 Oct 2009 23:00:00 +0100 2881581 http://www.medworm.com/index.php?rid=2866406&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00752.x (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2866406 Tue, 06 Oct 2009 23:00:00 +0100 2866406 http://www.medworm.com/index.php?rid=2866405&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00743.x Conclusion These results suggest that stimulation of several pro-inflammatory cytokines occurs very early in the cascade of events and remains increased, whereas anti-inflammatory cytokines are either unchanged or decreased until the onset of delivery in an inflammation-induced mouse model of pre-term labor. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2866405 Tue, 06 Oct 2009 23:00:00 +0100 2866405 http://www.medworm.com/index.php?rid=2866404&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00742.x Problem Human Leukocyte Antigen (HLA)-G is a class Ib gene located in the human major histocompatibility complex (MHC). Several lines of investigation indicate that the HLA-G molecule is involved in the maternal acceptance of the semi-allogenic fetus during pregnancy and in the development of tolerance. Expression of soluble HLA-G (sHLA-G) is positively correlated with successful in vitro fertilization (IVF) treatments, and aberrant expression of HLA-G in certain complications of pregnancy, such as pre-eclampsia and spontaneous abortion, has been reported. The main purpose of this study was to investigate the levels of different soluble HLA-G isoforms in maternal plasma in early and late pregnancy.Method of study Soluble HLA-G (sHLA-G) can be detected in maternal blood, and in this study, ... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2866404 Tue, 06 Oct 2009 23:00:00 +0100 2866404 http://www.medworm.com/index.php?rid=2866403&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00741.x Conclusion The information concerning the live birth rate can be given to each patient before subsequent pregnancy. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2866403 Tue, 06 Oct 2009 23:00:00 +0100 2866403 http://www.medworm.com/index.php?rid=2866402&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00740.x Conclusion Interleukin-23 and IL-12 share a common p40 subunit and no inhibition of IL-12 was apparent. It appeared that a component of mid-trimester amniotic fluid specifically interacts with the p19 subunit unique to IL-23. Mid-trimester amniotic fluid reactivity with IL-23 may be a mechanism to limit intra-amniotic neutrophil-derived inflammation. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2866402 Tue, 06 Oct 2009 23:00:00 +0100 2866402 http://www.medworm.com/index.php?rid=2866401&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00739.x Conclusion Mechanisms of possible efficacy of HIVIg therapy for RSA may include enhancement of CD94 expression and subsequent suppression of NK cell cytotoxicity. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2866401 Tue, 06 Oct 2009 23:00:00 +0100 2866401 http://www.medworm.com/index.php?rid=2866400&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00738.x Conclusion Maternal PE and PA were associated with an increased risk of severe atopy, especially in male adolescent offspring. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2866400 Tue, 06 Oct 2009 23:00:00 +0100 2866400 http://www.medworm.com/index.php?rid=2866399&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00737.x Conclusion Our data suggest PD-1 as an important mediator in Treg-induced fetal protection in the CBA/J × DBA/2J murine model. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2866399 Tue, 06 Oct 2009 23:00:00 +0100 2866399 http://www.medworm.com/index.php?rid=2866398&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00736.x Conclusion Our study confirms that cytokines rarely act in isolation, but rather in a network of other cytokines and may affect sperm function directly or indirectly. The presence of increased levels of cytokines in the obstructed azoospermic group suggests that the cytokines may not originate from the testis. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2866398 Tue, 06 Oct 2009 23:00:00 +0100 2866398 http://www.medworm.com/index.php?rid=2727863&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00735.x Conclusion The correlation patterns of TNF-[alpha] with IL-10 and TNF-[alpha] with IL-6 and IL-8 suggest disparity in functional regulations between these cytokines in maternal circulation in PE. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2727863 Mon, 24 Aug 2009 23:00:00 +0100 2727863 http://www.medworm.com/index.php?rid=2727864&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00734.x Conclusion Significant difference in serum IL-6 levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2727864 Sun, 23 Aug 2009 23:00:00 +0100 2727864 http://www.medworm.com/index.php?rid=2725720&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00729.x Conclusion Urocortin stimulates IL-4 and IL-10 secretion and reverses LPS-induced TNF-[alpha] release from trophoblast cells through action on CRH-R2 receptors, suggesting that this peptide may play a possible role as an anti-inflammatory agent. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2725720 Sun, 23 Aug 2009 23:00:00 +0100 2725720 http://www.medworm.com/index.php?rid=2725719&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00730.x Problem To determine whether adenosine in amniotic fluid down-regulates pro-inflammatory cytokine production.Method of study Mid-trimester amniotic fluid from 21 women was incubated ex vivo in the presence or absence of human adenosine deaminase, the enzyme that irreversibly degrades adenosine. After 24 hr, supernatants were assayed by ELISA for tumor necrosis factor-[alpha] (TNF-[alpha]), interleukin (IL)-6, and IL-10. Clinical parameters were obtained after completion of laboratory testing.Results Inclusion of adenosine deaminase resulted in a median increase in TNF-[alpha] production from 0.9 to 7.3 pg/mL (P = 0.0014). IL-6 production exhibited a non-significant median increase from (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2725719 Sun, 23 Aug 2009 23:00:00 +0100 2725719 http://www.medworm.com/index.php?rid=2725718&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00731.x Conclusion These findings did not support a major role of complement activation in the HELLP syndrome. In patients with HELLP, lower levels of FH are correlated with a reduced platelet count. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2725718 Sun, 23 Aug 2009 23:00:00 +0100 2725718 http://www.medworm.com/index.php?rid=2725717&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00732.x Conclusion Tlr5, Tlr10, and Tlr11 are ubiquitously expressed in the rat. Tlrs seem to be expressed during male reproductive tract development and under conditions of androgen ablation, suggesting the preparedness of the male reproductive tract to detect an infection under all conditions of androgen status. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2725717 Sun, 23 Aug 2009 23:00:00 +0100 2725717 http://www.medworm.com/index.php?rid=2725716&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00733.x Conclusion In patients with a history of miscarriage, infertility, and coagulant defects receiving immunotherapy, fondaparinux resulted in successful pregnancy outcomes comparable with enoxaparin therapy. Although no difference in outcome was observed in our analysis, a much larger study is required to achieve statistical power. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2725716 Sun, 23 Aug 2009 23:00:00 +0100 2725716 http://www.medworm.com/index.php?rid=2685728&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00721.x Conclusion These observations suggested that the aborted fetuses from RSA of unknown etiology, i.e. no chromosomal abnormality and no autoantibody, were preferentially female. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2685728 Tue, 11 Aug 2009 10:01:20 +0100 2685728 http://www.medworm.com/index.php?rid=2685735&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00728.x Conclusion We found no difference in C3a levels between women with and without endometriosis and did not confirm our hypothesis that plasma C3a levels can be used as diagnostic test for endometriosis. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2685735 Mon, 10 Aug 2009 23:00:00 +0100 2685735 http://www.medworm.com/index.php?rid=2685734&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00727.x Conclusion Our data implicate TNF-[alpha] to be involved in the protection of the embryo against CP teratogenicity, possibly via alteration in Bax, bcl-2 or p53 expression. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2685734 Mon, 10 Aug 2009 23:00:00 +0100 2685734 http://www.medworm.com/index.php?rid=2685733&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00726.x Conclusion Our findings suggest that the female sex hormones hCG and E2 inhibit the T-cell stimulatory capacity of DCs, which may help in preventing an allogenic T-cell response against the embryo. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2685733 Mon, 10 Aug 2009 23:00:00 +0100 2685733 http://www.medworm.com/index.php?rid=2685732&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00725.x Conclusion Circulating immuno-regulatory molecules fluctuate over the menstrual cycle in healthy women. The combination of differentially expressed molecules suggests roles in cyclical regulation of angiogenesis and immune cell trafficking. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2685732 Mon, 10 Aug 2009 23:00:00 +0100 2685732 http://www.medworm.com/index.php?rid=2685731&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00724.x Conclusions Our results suggest that the peripheral NK-cell pool is skewed in preeclampsia and possibly under the influence of monokines like interleukin (IL)-15 and IL-12. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2685731 Mon, 10 Aug 2009 23:00:00 +0100 2685731 http://www.medworm.com/index.php?rid=2685730&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00723.x Conclusion We revealed replication of low pathogenic influenza virus in the first trimester trophoblast cell lines. Placental damages are likely to be induced by direct cytopathic effects of influenza virus and subsequent apoptosis rather than down regulation of HLA-G expression and subsequent rejection by maternal immune system. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2685730 Mon, 10 Aug 2009 23:00:00 +0100 2685730 http://www.medworm.com/index.php?rid=2685729&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00722.x Conclusion These findings suggest that neutrophils and T cells release differential levels of IP-10 and IL-8 in response to stimulation with ePF, and that these cells are a major source of IP-10 in the PF of endometriosis patients. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2685729 Mon, 10 Aug 2009 23:00:00 +0100 2685729 http://www.medworm.com/index.php?rid=2581664&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00719.x Conclusion These results suggest that the RPR test might be used to identify a subset of women who warrant further testing for autoimmune and/or thromboembolic disease. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2581664 Thu, 09 Jul 2009 10:34:53 +0100 2581664 http://www.medworm.com/index.php?rid=2581669&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00720.x Conclusion It is suggested that seminal plasma participates in the recruitment of CD56bright NK cells into endometrium. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2581669 Wed, 08 Jul 2009 23:00:00 +0100 2581669 http://www.medworm.com/index.php?rid=2581668&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00718.x Problem To investigate whether polymorphisms in the interleukin-1[beta] (IL-1[beta]) gene are associated with uterine leiomyoma.Method of study Case[ndash]control study in a collective of 131 patients and 280 controls. Genotyping of the IL-1[beta]-511 and IL-1[beta]-3954 polymorphism was performed by PCR amplification and subsequent RFLP analysis.Results A significant difference in the allele frequencies of the IL-1[beta]-511 C (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2581668 Wed, 08 Jul 2009 23:00:00 +0100 2581668 http://www.medworm.com/index.php?rid=2581667&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00717.x Conclusion These findings demonstrate that aPL triggers a placental inflammatory response via the TLR-4/MyD88 pathway, which in turn compromises trophoblast survival. Thus, the TLR-4/MyD88 pathway may provide a new therapeutic target to improve pregnancy outcome in antiphospholipid syndrome patients. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2581667 Wed, 08 Jul 2009 23:00:00 +0100 2581667 http://www.medworm.com/index.php?rid=2581666&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00715.x Conclusion These findings suggest that trophoblasts might produce ATX and its bioactive resultant substance, LPA, paralleled with gestational weeks. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2581666 Wed, 08 Jul 2009 23:00:00 +0100 2581666 http://www.medworm.com/index.php?rid=2581665&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00716.x Epigenetics is focused on understanding the control of gene expression beyond what is encoded in the sequence of DNA. Central to growing interest in the field is the hope that more can be learned about the epigenetic regulatory mechanisms underlying processes of human development and disease. Researchers have begun to examine epigenetic alterations [ndash] such as changes in promoter DNA methylation, genomic imprinting, and expression of miRNA [ndash] to learn more about epigenetic regulation in the placenta, an organ whose proper development and function are crucial to the health, growth, and survival of the developing fetus. A number of studies are now making important links between alterations to appropriate epigenetic regulation in the placenta and diseases of gestation and early life.... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2581665 Wed, 08 Jul 2009 23:00:00 +0100 2581665 http://www.medworm.com/index.php?rid=2470055&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00712.x Abstract Toll-like receptors are an important family of pattern recognition receptors. They recognize microbial conserved components and trigger protective responses to the invading pathogens, which constitute a major part of the innate immune system. Toll-like receptors are mainly expressed in immune cells. The current evidences demonstrate that Toll-like receptors are present in some epithelial cells and epithelium derived tumor cells. The expression of Toll-like receptors in these cells is related to infection and inflammation, and tumor progression as well. Genital mucosal epithelium is the first line in defense of microorganism invasion in the female reproductive tract. Toll-like receptors expressed in the genital tract have been implicated in many aspects of reproductive physiology a... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2470055 Thu, 11 Jun 2009 01:13:18 +0100 2470055 http://www.medworm.com/index.php?rid=2470061&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00713.x Conclusion This study demonstrates that CCL20/MIP3[alpha] is an important endogenous anti-HIV-1 microbicide of the female reproductive tract. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2470061 Tue, 09 Jun 2009 04:00:00 +0100 2470061 http://www.medworm.com/index.php?rid=2470060&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00711.x Conclusion The results obtained indicate that changes in activities of intra-testicular cytokines may promote different distinct pathologies such as testicular cancer or infertility. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2470060 Tue, 09 Jun 2009 04:00:00 +0100 2470060 http://www.medworm.com/index.php?rid=2470059&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00710.x Conclusion Our findings suggested that the calcineurin/NFAT pathway might play a substantial role in initiation of labor. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2470059 Tue, 09 Jun 2009 04:00:00 +0100 2470059 http://www.medworm.com/index.php?rid=2470058&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00709.x Conclusion Our results indicate that RM could be associated with NK cell activation mediated by a profile rich in activating KIR genes. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2470058 Tue, 09 Jun 2009 04:00:00 +0100 2470058 http://www.medworm.com/index.php?rid=2470057&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00707.x Conclusion Progesterone up-regulates the expression by MSCs of HLA-G which is a major player in maintenance of the immune balance between the mother and the fetus. MSCs are newly detected targets of progesterone with well documented immunomodulatory activity. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2470057 Tue, 09 Jun 2009 04:00:00 +0100 2470057 http://www.medworm.com/index.php?rid=2470056&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00714.x Conclusion Identification of the immunological mechanisms involved in pregnancy loss and the action of different therapeutic reagents is important so that effective therapies can be designed and investigated. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2470056 Tue, 09 Jun 2009 04:00:00 +0100 2470056 http://www.medworm.com/index.php?rid=2390599&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00708a.x (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2390599 Thu, 07 May 2009 11:59:54 +0100 2390599 http://www.medworm.com/index.php?rid=2390600&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00708.x (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2390600 Wed, 06 May 2009 04:00:00 +0100 2390600 http://www.medworm.com/index.php?rid=2382898&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00705.x Conclusion A unique population of memory T lymphocytes expressing both [alpha]4[beta]7 and CLA gain access to reproductive tract tissues during a sexually transmitted infection with C. trachomatis and should be considered in development of vaccines against sexually transmitted infections. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2382898 Sun, 03 May 2009 04:00:00 +0100 2382898 http://www.medworm.com/index.php?rid=2304072&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00697.x Conclusion Our findings implicate that the functional changes of human circulating B-cells might contribute to the etiology of pre-eclampsia. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2304072 Tue, 07 Apr 2009 00:57:00 +0100 2304072 http://www.medworm.com/index.php?rid=2304092&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00703.x Conclusion The data showed increased sHLA-G and IL-10 concentrations at delivery, regardless of the allergic status. The sHLA-G1 isoform is mainly responsible for the increased sHLA-G levels at delivery. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2304092 Wed, 01 Apr 2009 04:00:00 +0100 2304092 http://www.medworm.com/index.php?rid=2304088&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00702.x Conclusion Here we report for the first time that CD55 mRNA expression was elevated in the peripheral WBCs of subjects with preterm labor compared with control gestationally-matched pregnant woman and that elevated leukocyte CD55 may be a useful predictor of subsequent PTB. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2304088 Wed, 01 Apr 2009 04:00:00 +0100 2304088 http://www.medworm.com/index.php?rid=2304084&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00701.x Conclusion Leukocytes are activated in preeclampsia. A pro-inflammatory gene expression profile is not prominent, although differences in mRNA expression can be detected. Increased levels of particular subsets of leukocyte-derived MP reflect activation of their parental cells in preeclampsia. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2304084 Wed, 01 Apr 2009 04:00:00 +0100 2304084 http://www.medworm.com/index.php?rid=2304080&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00700.x Conclusion The expression of TLRs is cycle dependent in human endometrial tissue. The expressions of TLRs were higher in the secretory phase than that in the proliferative phase: this indicated that TLRs may be regulated by sex hormones throughout the menstrual cycle. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2304080 Wed, 01 Apr 2009 04:00:00 +0100 2304080 http://www.medworm.com/index.php?rid=2304076&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00698.x Conclusion Infertile women with CE showed an abnormal percentage of endometrial lymphocyte subsets compared with unexplained infertile women suggesting that different mechanisms underlie the adverse pregnancy outcome of the two groups of patients. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2304076 Wed, 01 Apr 2009 04:00:00 +0100 2304076 http://www.medworm.com/index.php?rid=2230543&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00693.x Conclusion Interleukin-17 may regulate the function of JEG-3 cells through increased progesterone secretion. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2230543 Wed, 04 Mar 2009 13:03:55 +0100 2230543 http://www.medworm.com/index.php?rid=2230548&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00696.x Conclusion The alterations in both the Treg cell and suppressive B7H4+ macrophage subpopulations would seem to be related to the suppression of maternal immune cells in the endometrium at the beginning of decidualization. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2230548 Mon, 02 Mar 2009 05:00:00 +0100 2230548 http://www.medworm.com/index.php?rid=2230547&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00694.x Conclusion: This study demonstrates that LPS, through TLR4, increases trophoblast expression of Nod1 and Nod2 via the NF[kappa]B pathway; and that Nod1 is functional in the trophoblast. These findings suggest that extracellular recognition of bacterial LPS by TLR4 may prime the trophoblast in preparation for its cytoplasmic recognition of, and response to, bacterial peptides through the Nod proteins. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2230547 Mon, 02 Mar 2009 05:00:00 +0100 2230547 http://www.medworm.com/index.php?rid=2230546&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00692.x Conclusion Osteopontin may be involved in the pathogenesis of endometriosis and plasma OPN may be a useful non-invasive marker for the diagnosis of endometriosis. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2230546 Mon, 02 Mar 2009 05:00:00 +0100 2230546 http://www.medworm.com/index.php?rid=2230545&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00691.x Conclusion Tumor necrosis factor [alpha] may be involved in cell proliferation of endometriotic tissues. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2230545 Mon, 02 Mar 2009 05:00:00 +0100 2230545 http://www.medworm.com/index.php?rid=2230544&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00688.x Conclusion In infertile women, changes in circulating NK cell percentages are found exclusively during the secretory phase and not in endometrium; cycle-related changes in NK receptor expression are observed only in infertile endometrium. While having exciting implications for understanding NK cell function in fertility, our data emphasize the difficulty in attaching diagnostic or prognostic significance to NK cell analyses in individual patients. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2230544 Mon, 02 Mar 2009 05:00:00 +0100 2230544 http://www.medworm.com/index.php?rid=2180853&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00689.x Conclusion TSP-1 on DM[Phi] could influence IL-10 expression as Th2 cytokines. The abnormal expression of TSP-1 could make some women undergo pregnancy loss. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2180853 Thu, 12 Feb 2009 05:00:00 +0100 2180853 http://www.medworm.com/index.php?rid=2180852&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00687.x Conclusion Our results may indicate that lactobacilli in maternal vagina influence the development of neonatal immune system. Yet, more research is needed using specified bacterial antigens. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2180852 Thu, 12 Feb 2009 05:00:00 +0100 2180852 http://www.medworm.com/index.php?rid=2180851&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00686.x Conclusion Immunologic cause of male infertility is a very important risk factor in the pathogenesis of sperm cells. Sperm autoantibodies and the presence of intra-acrosomal factors must be studied together, cytokines according to accessory cellularity in the semen. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2180851 Thu, 12 Feb 2009 05:00:00 +0100 2180851 http://www.medworm.com/index.php?rid=2180850&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00685.x Conclusion pCXN2-mIzumo plasmid possesses appreciable anti-fertility potential. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2180850 Thu, 12 Feb 2009 05:00:00 +0100 2180850 http://www.medworm.com/index.php?rid=2180849&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00684.x Conclusion These results suggest that progesterone up-regulates HLA-E expression in JEG-3 cells through the pathway mediated by progesterone receptor. Our findings might give a new insight into immunomodulatory function of progesterone at fetomaternal interface. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2180849 Thu, 12 Feb 2009 05:00:00 +0100 2180849 http://www.medworm.com/index.php?rid=2180848&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2009.00683.x Conclusion Our study showed the presence of TH2 hypoactivity in women with reproduction failure, which may be associated with lower occurrence of atopic diseases. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2180848 Thu, 12 Feb 2009 05:00:00 +0100 2180848 http://www.medworm.com/index.php?rid=2180847&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00682.x Conclusion We report that Poly[I:C] induces preterm delivery via TLR3-dependent manner. Furthermore, we demonstrate that the trophoblast is able to recognize Poly[I:C] through TLR3 and respond to viral infection, modulating the immune system at the feto-maternal interface. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2180847 Thu, 12 Feb 2009 05:00:00 +0100 2180847 http://www.medworm.com/index.php?rid=2180846&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00681.x Conclusion Although high concentrations of SASP inhibit IL-8 production by cultures of endocervical cells stimulated with pathogens associated with preterm birth, this effect may be because of toxicity of the antibiotic on the cells. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2180846 Thu, 12 Feb 2009 05:00:00 +0100 2180846 http://www.medworm.com/index.php?rid=2162791&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00676.x Conclusion The incidence of ASA in males with systemic autoimmune diseases was significantly higher than in the healthy controls. Systemic autoimmune diseases may be one of the risk factors for developing ASA in men. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2162791 Fri, 06 Feb 2009 04:56:26 +0100 2162791 http://www.medworm.com/index.php?rid=2114775&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00673.x Conclusion Although understanding the regulation of IFNT expression is far from complete, considerable progress has been made in uncovering how uterine-derived factors and key placental-specific transcriptional regulators control IFNT expression. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2114775 Tue, 20 Jan 2009 04:27:18 +0100 2114775 http://www.medworm.com/index.php?rid=2114783&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00679.x Conclusion We detected several differences in the levels of AGEs, sRAGE, and proinflammatory cytokines between euglycemic and diabetic pregnancies. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2114783 Sun, 11 Jan 2009 05:00:00 +0100 2114783 http://www.medworm.com/index.php?rid=2114782&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00678.x Conclusion Elastin degradation is decreased during normal pregnancy. Increased anti-elastin IgG antibodies may contribute to the pathogenesis of pregnancy losses. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2114782 Sun, 11 Jan 2009 05:00:00 +0100 2114782 http://www.medworm.com/index.php?rid=2114781&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00677.x Conclusion The presented results demonstrate, for the first time, that LPS exposure during pregnancy may be determined by measuring VER in mothers without any adverse effect on ongoing pregnancy and may help in refining the assisted reproduction techniques. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2114781 Sun, 11 Jan 2009 05:00:00 +0100 2114781 http://www.medworm.com/index.php?rid=2114780&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00675.x Problem Comparison of two types of immunocompromised mouse strains (SCID and NOD/SCID) for production of human antisperm antibodies (AsA).Method of study Human peripheral blood lymphocytes (PBL) were grafted to mouse peritoneal cavity and sensitized with natively glycosylated and N-deglycosylated sperm extracts.Results and conclusion NOD/SCID mice inoculated with hu-PBLs exhibited higher AsA titres with a tendency for greater sperm agglutination than human AsA raised in SCID mouse model. A comparison between 'native' and deglycosylated sperm extracts revealed higher agglutination titres by sera induced with the latter ones. Inhibitory effect of human polyclonal AsA in sperm penetration assay, however, produced opposite results to that for agglutination. Western immunoblotting was used to e... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2114780 Sun, 11 Jan 2009 05:00:00 +0100 2114780 http://www.medworm.com/index.php?rid=2114779&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00674.x Conclusion These changes in the Treg cell subpopulation in the decidua would seem to be related to a brief activation of the maternal immune system as labor begins and lack of analogical changes in the subpopulation of decidual suppressive B7-H4+ macrophages that enable the restriction of this same activation as labor progresses. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2114779 Sun, 11 Jan 2009 05:00:00 +0100 2114779 http://www.medworm.com/index.php?rid=2114778&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00672.x Conclusion As PI3K are involved in signal transduction of various leukocyte receptors, this downregulation may comprise a means of holding immune functions at bay. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2114778 Sun, 11 Jan 2009 05:00:00 +0100 2114778 http://www.medworm.com/index.php?rid=2114777&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00670.x Conclusion Daily use of a diaphragm with placebo or acidifying microbicide gel did not cause cervicovaginal inflammation. However, diaphragm/BG use was associated with markedly reduced levels of SLPI, an important mediator of innate immune defense. Further studies are warranted to establish the safety of diaphragm/microbicide gel combinations. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2114777 Sun, 11 Jan 2009 05:00:00 +0100 2114777 http://www.medworm.com/index.php?rid=2114776&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00680.x (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2114776 Sun, 11 Jan 2009 05:00:00 +0100 2114776 http://www.medworm.com/index.php?rid=2012815&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00669.x Problem The purpose of this study was to investigate whether treatment with TNF-[alpha] inhibitors and/or intravenous immunoglobulin (IVIG) increases in vitro fertilization (IVF) success rates among young ( (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=2012815 Fri, 05 Dec 2008 04:48:16 +0100 2012815 http://www.medworm.com/index.php?rid=1954430&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00671.x Maternal asthma significantly increases the risk of asthma in offspring, but the mechanisms remain poorly defined. We review animal models used to study the maternal effect, focusing on a murine model developed in our laboratory. Mother mice rendered allergic to ovalbumin produce offspring that are more susceptible to allergic sensitization, seen as airway hyperresponsiveness and allergic airway inflammation after a sensitization protocol, which has minimal effects on newborns from normal mothers. Mechanistic analyses identify a role for interleukin-4 (based on pre-mating injection of neutralizing antibodies), dendritic cells and allergen-specific T cells (based on adoptive transfer experiments). Other maternal exposures (e.g. pollutant exposure and non-pulmonary allergy) can increase asth... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=1954430 Thu, 13 Nov 2008 05:00:00 +0100 1954430 http://www.medworm.com/index.php?rid=1875063&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00657.x Macrophages are apparently the only immune cells within placenta villi, yet functions of these cells remain obscure. It has been postulated that placental macrophages accomplish regulatory roles at the fetal[ndash]maternal interface by means of wide variety of secreted cytokines. We attempt to analyze the patterns of cytokine production in an isolated population of placental macrophages. Macrophages were obtained from term placentas in the absence of spontaneous labor. The basal and lipopolysaccharide (LPS)-stimulated levels of intracellular cytokines were detected by flow cytometry. The basal cytokine secretion was determined by BD[trade]Cytometry Bead Array (BD Biosciences, San Diego, CA, USA). Intracellular IL-1[alpha], IL-1[beta], IL-6, and TNF[alpha] were detected in 31, 27, 4, and 3%... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=1875063 Wed, 15 Oct 2008 04:00:00 +0100 1875063 http://www.medworm.com/index.php?rid=1805157&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00640.x This study was undertaken to compare the frequencies of nine inherited thrombophilias among women with a history of recurrent pregnancy loss with individuals experiencing deep venous thrombosis and fertile controls. Six hundred thirty-four participants including 550 women with a history of recurrent pregnancy loss, 43 individuals with deep vein thrombosis and 41 fertile women without a history of recurrent miscarriage. All participants had buccal swabs taken for DNA analyses of nine gene polymorphisms including factor V G1691A, factor V H1299R (R2), factor II Prothrombin G20210A, factor XIII V34L, [beta]-fibrinogen [minus]455G>A, PAI-1 4G/5G, human platelet antigen 1 a/b (L33P), MTHFR C677T, MTHFR A1298C. Frequencies of thrombophilic gene polymorphisms were compared among the three populat... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=1805157 Fri, 19 Sep 2008 04:00:00 +0100 1805157 http://www.medworm.com/index.php?rid=1805158&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00637.x Chlamydia trachomatis is the most common sexually transmitted infection worldwide. While infection in females requires a Th1 response for clearance, such a response in males may disrupt the immune privileged nature of the male reproductive tract, potentially contributing to infertility. We investigated the role of IgA in protection against an intrapenile Chlamydia muridarum infection of C57BL/6 and pIgR[minus]/[minus] mice. Here, we show that the poly immunoglobulin receptor is the main pathway for IgA transport into the male reproductive tract. The high levels of IgA seen in prostatic fluid of wild-type mice correlate with reduction in chlamydial infection both in vitro and in vivo. These findings indicate that a Chlamydia vaccine that induces neutralizing IgA in the prostate will aid in ... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=1805158 Thu, 18 Sep 2008 04:00:00 +0100 1805158 http://www.medworm.com/index.php?rid=1801826&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00639.x The endocervix is a major target of Chlamydia trachomatis infection, but little is known about the immune repertoire in this tissue, or its response to these common bacteria. Using a cytobrush, we isolated cells from the endocervix of 20 women during C. trachomatis infection, and post-antibiotic treatment. Endocervical swabs and blood were taken in parallel. Endocervical cells were enumerated, and endocervical and blood T cells immunophenotyped. Chlamydia trachomatis was genotyped by sequence analysis of the OmpA gene, and quantified by culture. Chlamydia trachomatis genotypes were D, E, F and Ia, and infectious burden varied considerably. Endocervical T cell and neutrophil numbers were highly elevated during infection, with both CD4 and CD8 T-cell subsets accumulating. Regardless of the p... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=1801826 Thu, 18 Sep 2008 04:00:00 +0100 1801826 http://www.medworm.com/index.php?rid=1737867&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00622.x Conclusion Results suggested that mechanisms for maternal tolerance of paternal alloantigens, including mismatched MHC antigens, were intact in these pregnancies, yet maternal immune-dependent paternal antigen-independent abortion of mutants occurred. These data indicate that, in some cases of immune-mediated abortions, the presence of paternal alloantigens can be coincidental and superfluous to the compromising rejection response. (Source: American Journal of Reproductive Immunology) American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=1737867 Fri, 29 Aug 2008 04:00:00 +0100 1737867 http://www.medworm.com/index.php?rid=1732676&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00629.x Pre-eclampsia is associated with excessive maternal systemic inflammatory response. The immune cells in ascites of pre-eclampsia have not been studied well. In order to investigate the inflammatory response in ascites of pre-eclampsia, we studied leukocytes subpopulation in ascites. Maternal peripheral blood samples and ascites were taken from 10 cases of pre-eclampsia. Antibody-labeled cells were analyzed by flow cytometry. The leukocytes subpopulation in ascites taken from pre-eclampsia was different from that in the peripheral blood. The largest population of leukocytes in ascites was CD14+ monocyte/macrophage. The percentages of macrophage, CD56+ cells, CD56 + 16[minus]3[minus] NK cell (immunoregulatory NK cell), and CD56 + 3+ T cell (CD56+ T cell including NK T cell) increased in asci... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=1732676 Wed, 27 Aug 2008 04:00:00 +0100 1732676 http://www.medworm.com/index.php?rid=1732675&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00625.x We evaluated associations between a length polymorphism in intron 2 of the gene coding for IL-1ra (gene symbol IL1RN) and pregnancy outcome in a population with a high rate of preterm birth. Subjects were pregnant women in Maceio, Brazil and their newborns. DNA was tested for IL1RN genotypes and alleles by gene amplification using primer pairs that spanned the polymorphic region. Every subject completed a detailed questionnaire. The frequency of allele 2 (IL1RN*2) carriage was elevated in mothers with a spontaneous preterm birth (SPTB) in the current pregnancy (P = 0.02) and also with a prior preterm delivery (P = .01). Both SPTB with intact membranes (P = 0.01) and SPTB preceded by pre-term pre-mature rupture of membranes (P = .03) were associated with IL1RN*2 carriage. A previous fetal d... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=1732675 Wed, 27 Aug 2008 04:00:00 +0100 1732675 http://www.medworm.com/index.php?rid=1732674&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00630.x Recurrent miscarriage (RM) affects 1[ndash]3% of couples. So far, diagnostic procedures are performed only in female patients. However, the main part of the placentary perfusion is encoded by both the maternal and the paternal genome. In this case[ndash]control study, German couples with two (n = 49) or three and more RM (n = 102) and 157 German control couples were analyzed for the factor V-Leiden 1691G>A mutation (FVL), the prothrombin (PT) 20210G>A substitution, and the 677C>T replacement in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. No significant differences in the prevalence of the FVL, PT or MTHFR mutation were observed in male partners of RM patients and in control men [RM/control: FVL heterozygous 13/151 (8.6%): 14/157 (8.9%) (P = 0.9); PT heterozygous 2/151 (1.3%)... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=1732674 Wed, 27 Aug 2008 04:00:00 +0100 1732674 http://www.medworm.com/index.php?rid=1728885&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00631.x The objective of this study was to determine maternal plasma MBL concentrations in normal pregnant women and patients with pre-eclampsia. This cross-sectional study included normal pregnant women (n = 187) and patients with pre-eclampsia (n = 99). Maternal plasma MBL concentrations were determined by ELISA. Women with pre-eclampsia had a higher median maternal plasma MBL concentration than normal pregnant women. MBL concentration distribution curves were three-modal, the subintervals in normal pregnancy were low (1898.9 ng/mL). The proportion of normal pregnant women was larger in the low subinterval, while the proportion of patients with pre-eclampsia was larger in the high subinterval (P = 0.02). Normal pregnant women in the high subinterval had a larger rate of placental underperfusion ... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=1728885 Sun, 24 Aug 2008 04:00:00 +0100 1728885 http://www.medworm.com/index.php?rid=1691078&cid=s_33161_3_f&fid=33161&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0897.2008.00624.x Galectin-1 can regulate immune responses upon infection and inflammation. We determined galectin-1 expression in the chorioamniotic membranes and its changes during histological chorioamnionitis. Chorioamniotic membranes were obtained from women with normal pregnancy (n = 5) and from patients with pre-term pre-labor rupture of the membranes (PPROM) with (n = 8) and without histological chorioamnionitis (n = 8). Galectin-1 mRNA and protein were localized by in situ hybridization and immunohistochemistry. Galectin-1 mRNA expression was also determined by quantitative reverse transcriptase polymerase chain reaction. Galectin-1 mRNA and protein were detected in the amniotic epithelium, chorioamniotic fibroblasts/myofibroblasts and macrophages, chorionic trophoblasts, and decidual stromal cells... American Journal of Reproductive Immunology journals http://www.medworm.com/rss/comments.php?id=1691078 Sat, 09 Aug 2008 04:00:00 +0100 1691078