MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Angiology' source. Wed, 08 Feb 2012 09:32:27 +0100 http://www.medworm.com/index.php?rid=5597104&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F63%2F2%2F155%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5597104 Mon, 16 Jan 2012 05:00:00 +0100 5597104 http://www.medworm.com/index.php?rid=5597103&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F150%3Frss%3D1 We tested the hypothesis that the Ankle-Brachial Index (ABI) in patients without peripheral arterial disease ([PAD] ABI > 1.0) is an indicator of arterial stiffness. Fifty-five patients had measurement of carotid pulse wave contour, pulse wave velocity (PWV), and ABI. Vascular stiffness as assessed by augmentation index (AIx) showed a significant (P = .002) inverse correlation with ABI. Dichotomizing ABI into groups above and below the median showed that persons with a lower ABI, >1.0 to 1.5 (n = 27) had a significantly (P < .01) higher AIx than those with a higher ABI > 1.5 (n = 28). In contrast, vascular stiffness assessed by brachial-ankle or carotid femoral PWV did not correlate with ABI. In summary, ABI is an indicator of arterial stiffness assessed by AIx. Vascular change... Angiology journals http://www.medworm.com/rss/comments.php?id=5597103 Mon, 16 Jan 2012 05:00:00 +0100 5597103 http://www.medworm.com/index.php?rid=5597102&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F146%3Frss%3D1 Small studies suggest an association between abdominal aortic aneurysms (AAAs) and hernias, possibly related to connective tissue weakness. We evaluated the association between AAA and abdominal wall hernia (AWH), using peripheral arterial disease (PAD) patients as controls, in Olmsted County, Minnesota. In a retrospective cohort study we queried the electronic medical records for the diagnosis of AAA. The resulting data were then queried for prevalence of AWH. The same set of queries was repeated for PAD. Occurrence of AWH in the 2 groups was compared using the chi-square test. Of the 187 151 patient records queried, 939 had AAA and 3465 had PAD. Abdominal wall hernia occurred in 157 (16.7%) patients with AAA and in 343 (9.9%) patients with PAD. Abdominal wall hernia was 1.7 times more pr... Angiology journals http://www.medworm.com/rss/comments.php?id=5597102 Mon, 16 Jan 2012 05:00:00 +0100 5597102 http://www.medworm.com/index.php?rid=5597101&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F138%3Frss%3D1 Pharmacomechanical thrombolysis (PMT) is an emerging treatment option for symptomatic deep vein thrombosis (DVT). This may obviate the need for systemic or catheter-directed thrombolysis. PubMed, EMBASE, and Cochrane database search of PMT in acute and chronic symptomatic DVT was undertaken. Baseline demographic and clinical characteristics, procedural details, DVT characteristics, and procedural and clinical outcomes are presented. A total of 8 case series (n = 2528; 1998-2009) qualified for inclusion. Lower extremity symptomatic DVTs constituted the majority of the cases (>80%). Both acute (<14 days) and chronic (>14 days) DVTs were included. Procedural success was 59% to 100% and catheter-directed thrombolysis was used as an adjunct in 16% to 53%. No deaths or major bleeding co... Angiology journals http://www.medworm.com/rss/comments.php?id=5597101 Mon, 16 Jan 2012 05:00:00 +0100 5597101 http://www.medworm.com/index.php?rid=5597100&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F131%3Frss%3D1 There are conflicting reports about the association of endothelial nitric oxide synthase (eNOS) gene polymorphism and the risk of coronary artery disease (CAD). To determine the frequency of eNOS G894T variant and to find the possible association between this polymorphism with CAD we studied 207 unrelated patients with total CAD (with and without diabetes) and 92 controls. The eNOS variants were detected by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The presence of GT + TT genotype was associated with 2.1-fold (P = .006), 2.29-fold (P = .006), and 1.93-fold (P = .032) increased risk of CAD in total CAD, CAD with diabetes, and in CAD without diabetes patients, respectively. The presence of T allele of eNOS increased the risk of CAD 2.15-fold (P = .0... Angiology journals http://www.medworm.com/rss/comments.php?id=5597100 Mon, 16 Jan 2012 05:00:00 +0100 5597100 http://www.medworm.com/index.php?rid=5597099&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F127%3Frss%3D1 We assessed whether macrophage colony-stimulating factor (M-CSF) levels are associated with left ventricular systolic dysfunction (LVSD) in patients with acute myocardial infarction (AMI). We studied 56 patients with AMI (mean age: 67 ± 12 years) and identified those with clinical (Killip class >II) or echocardiographic signs (ejection fraction ≤45%) of LVSD. We evaluated the established cardiovascular risk factors and measured several cardiovascular biomarkers, including M-CSF. Serum M-CSF concentrations (pg/mL) were significantly increased in patients with both clinical and echocardiographic signs of LVSD (460 ± 265 vs 290 ± 210, P = .0103 and 493 ± 299 vs 287 ± 174, P = .0028, respectively). We found a significant inverse association between M-CS... Angiology journals http://www.medworm.com/rss/comments.php?id=5597099 Mon, 16 Jan 2012 05:00:00 +0100 5597099 http://www.medworm.com/index.php?rid=5597098&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F119%3Frss%3D1 The prognostic value of admission estimated glomerular filtration rate (eGFR) calculated by the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula for cardiovascular adverse outcomes in acute coronary syndrome (ACS) was explored. Baseline eGFR was classified as no renal dysfunction (>90 mL/min per 1.73 m2), borderline (90-60.1 mL/min per 1.73 m2), moderate (60-30.1 mL/min per 1.73 m2), or severe (≤30 mL/min per 1.73 m2) renal dysfunction. Of the 5034 patients, 3415 (67.8%) had eGFR <90. Compared to patients with an eGFR ≥60 mL/min per 1.73 m2, patients with <60 mL/min per 1.73 m2 were less likely to be treated with β-blockers, angiotensin-converting enzyme inhibitors, or statins, or to undergo percutaneous coronary interventions. Lower eGFR showed a... Angiology journals http://www.medworm.com/rss/comments.php?id=5597098 Mon, 16 Jan 2012 05:00:00 +0100 5597098 http://www.medworm.com/index.php?rid=5597097&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F109%3Frss%3D1 We assessed the prevalence, predictors, and in-hospital and long-term outcomes of conservative medical management for patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) compared with percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG). This prospective study conducted from October 2008 to June 2009 in 65 hospitals from 6 Arabian Gulf countries included 30-day and 1-year mortality follow-up for 3661 patients. Compared with conservative management group (2859 patients; 78.1%), the PCI group (638; 17.4%) had significantly better unadjusted and adjusted in-hospital (odds ratio [OR]: 0.40, 95% confidence interval [CI]: 0.17-0.97), 30-day (OR: 0.44, 95% CI: 0.24-0.76) and 1-year (OR: 0.58, 95% CI: 0.40-0.87) mortality rates. Comparison w... Angiology journals http://www.medworm.com/rss/comments.php?id=5597097 Mon, 16 Jan 2012 05:00:00 +0100 5597097 http://www.medworm.com/index.php?rid=5597096&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F103%3Frss%3D1 The transradial approach (TRA) is commonly applied for coronary catheterization. However, there are few reports on the safety and feasibility of transradial catheterization in patients with prior coronary artery bypass graft (CABG) surgery. We retrospectively evaluated 124 consecutive patients who underwent graft angiography and intervention via the transradial (TRA group, n = 68) or transfemoral approach (TFA group, n = 56). The baseline clinical characteristics between the 2 groups were similar except for prior myocardial infarction. No significant difference (P > .05)was observed in procedure time, the success rate of puncture, angiography, and intervention procedure between the 2 groups. There was no significant difference in major adverse cardiac and cerebrovascular events during h... Angiology journals http://www.medworm.com/rss/comments.php?id=5597096 Mon, 16 Jan 2012 05:00:00 +0100 5597096 http://www.medworm.com/index.php?rid=5597095&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F96%3Frss%3D1 Adipose tissue can release proinflammatory mediators, namely C-reactive protein (CRP), interleukin 1β (IL-1β), and monocyte chemotactic protein 1 (MCP-1), contributing to vascular injury and insulin resistance (IR). Other mediators namely, adiponectin and nitric oxide (NO) are protective. We enrolled type 2 diabetes mellitus (T2DM) obese male patients without coronary heart disease ([CHD] group II, n = 25) and T2DM obese patients with CHD (group III, n = 25). They were compared with 20 age- and body mass index (BMI)-matched nondiabetic control males (group I). Fasting blood glucose (FBG), glycated hemoglobin (HbA1c%), lipids, insulin, malondialdehyde ([MDA]; lipid peroxidation product), NO, high-sensitivity CRP (hsCRP), IL-1β, MCP-1, adiponectin as well as sE-selectin concen... Angiology journals http://www.medworm.com/rss/comments.php?id=5597095 Mon, 16 Jan 2012 05:00:00 +0100 5597095 http://www.medworm.com/index.php?rid=5597094&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F92%3Frss%3D1 Mechanical plaque rupture of coronary atherosclerotic plaque during stent implantation can increase serum levels of high-sensitivity C-reactive protein (hsCRP). Patients with stable angina pectoris were divided into 2 groups: one group included 186 patients with de novo lesion who underwent stent implantation (de novo group); the other group included 40 patients with intrastent restenosis (ISR) undergoing stent implantation (ISR group). The de novo group had a significant increase in hsCRP levels post stenting, while the ISR group showed no increase in hsCRP post stenting. Intravascular ultrasound with radiofrequency data analysis showed that the de novo group had larger percentage of both necrotic core area and fibrofatty area at the target lesion than the ISR group, while the ISR group h... Angiology journals http://www.medworm.com/rss/comments.php?id=5597094 Mon, 16 Jan 2012 05:00:00 +0100 5597094 http://www.medworm.com/index.php?rid=5597093&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F86%3Frss%3D1 We assessed the influence of metabolic syndrome (MetS) characteristics on vascular complications. The study included 108 patients (72 women and 36 men, age 57.0 ± 8.5 years) with MetS that was diagnosed according to International Diabetes Federation criteria. The prevalence of micro- and macrovascular complications was assessed: vascular changes in the fundus of the eye—72%, ischemic heart disease—54.9%, estimated glomerular filtration rate (eGFR) <90 mL/min—38.9%, diabetic foot—5.55%, and cerebrovascular accident—3.7% of patients. A negative correlation between high-density lipoprotein cholesterol (HDL-C) concentration, creatinine levels, and level of vascular changes in the fundus of the eye was found. Moreover, the level of obesity and fasting glu... Angiology journals http://www.medworm.com/rss/comments.php?id=5597093 Mon, 16 Jan 2012 05:00:00 +0100 5597093 http://www.medworm.com/index.php?rid=5597092&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F63%2F2%2F84%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5597092 Mon, 16 Jan 2012 05:00:00 +0100 5597092 http://www.medworm.com/index.php?rid=5597091&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F2%2F81%3Frss%3D1 Both oral and intravenous administration of alpha-lipoic acid (ALA) has been investigated as add-on treatment for diabetic peripheral neuropathy. The recent Neurological Assessment of Thioctic Acid in Diabetic Neuropathy (NATHAN) 1 trial has shown that 4-year oral ALA administration is of some value in achieving a clinically meaningful improvement and a slight delay in the progression of neuropathic deficits among patients with mild/moderate diabetic peripheral neuropathy. Despite these promising results, important questions remain to be answered, mainly appropriate patient selection and optimal treatment duration. Moreover, a cost-benefit analysis would be useful. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5597091 Mon, 16 Jan 2012 05:00:00 +0100 5597091 http://www.medworm.com/index.php?rid=5476298&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F1%2F67%3Frss%3D1 In conclusion, RBP4 may significantly influence the metabolic pathways responsible for changes in ApoB lipoprotein subspecies, thus RBP4 may be associated with cardiovascular disease risk. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5476298 Sun, 04 Dec 2011 05:00:00 +0100 5476298 http://www.medworm.com/index.php?rid=5476297&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F1%2F62%3Frss%3D1 We evaluated the relationship between plasma inflammation markers and clopidogrel resistance in patients after stent implantation. The plasma levels of C-reactive protein (CRP), P-selectin, platelet soluble CD40 ligand (sCD40L), interleukin 6 (IL-6) and platelet aggregation were measured in 352 patients undergoing percutaneous coronary intervention (PCI) at baseline and after 6 months. The plasma levels of CRP, P-selectin, sCD40L, IL-6 was higher in 65 (18.5%) patients with clopidogrel resistance than in those with normal responsiveness at 6 months after PCI. There was a significant positive correlation between soluble CD40L levels and platelet aggregation (r = .28, P < .05). Diabetes (DM) and sCD40L level were independent predictors for unresponsiveness after stent implantation accordi... Angiology journals http://www.medworm.com/rss/comments.php?id=5476297 Sun, 04 Dec 2011 05:00:00 +0100 5476297 http://www.medworm.com/index.php?rid=5476296&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F1%2F55%3Frss%3D1 We enrolled 1461 Taiwanese type 2 diabetic outpatients with ankle-brachial index (ABI) and toe-brachial index (TBI) examinations, excluding participants with history of stroke, end-stage renal disease, malignancy, acute myocardial infarction, amputation, and overt calcification of the lower limbs (ABI >1.3). Ankle-brachial index values <0.9 were found in 2.8% of the patients and 5.7% had TBI <0.6. Estimated glomerular filtration rate (eGFR; 90 ± 33 mL/min per 1.73 m2) obtained from 473 patients correlated significantly with both ABI and TBI. Progressive eGFR decline was observed in 419 participants with normal ABI and TBI, 35 with normal ABI but low TBI, and 19 with low ABI and normal or low TBI (P for trend <.001). After adjusting for confounding factors, age and eGFR w... Angiology journals http://www.medworm.com/rss/comments.php?id=5476296 Sun, 04 Dec 2011 05:00:00 +0100 5476296 http://www.medworm.com/index.php?rid=5476295&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F1%2F48%3Frss%3D1 We describe the baseline characteristics, management, and outcomes of acute coronary syndrome (ACS) in patients of age ≤40 in the Gulf region of the Middle East. We studied 8176 hospitalized patients (≤40 years) with ACS. Ten percent (805) of the recruited patients were ≤40 years. The mean age was 37 years and 89% were males. The prevalence of smoking and diabetes in the young patients was high (58% and 21%, respectively). The most common ACS was ST elevation myocardial infarction. Younger patients were more aggressively treated with more frequent use of glycoprotein inhibitors, thrombolytics, and primary percutaneous coronary intervention. They had less in-hospital heart failure, left ventricular dysfunction, shock, stroke, and low rate of in-hospital mortality (1%). Measures to ... Angiology journals http://www.medworm.com/rss/comments.php?id=5476295 Sun, 04 Dec 2011 05:00:00 +0100 5476295 http://www.medworm.com/index.php?rid=5476294&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F1%2F39%3Frss%3D1 Conclusions: The prevalence of MetS varies considerably depending on the definition used in a hypertensive population in a Mediterranean country. These differences will influence risk assessment. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5476294 Sun, 04 Dec 2011 05:00:00 +0100 5476294 http://www.medworm.com/index.php?rid=5476293&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F1%2F35%3Frss%3D1 The pathophysiology of pregnancy-induced hypertension and preeclampsia may involve abnormalities in placentation and the Fas/Fas ligand system. Hypothesizing abnormal plasma Fas and Fas ligand in pregnancy-induced hypertension, we recruited 20 hypertensive pregnant women at mean week 15 and 29 at week 30: 18 were studied at both time points. Control groups were 20 normotensive pregnant women at week 20, 29 women at week 27, and 50 nonpregnant women. sFas and sFas ligand (sFasL) were measured by enzyme-linked immunosorbent assay (ELISA). The hypertensive women had lower sFasL at both stages of their pregnancy (P < .05). There were no differences in sFas. In 18 hypertensive pregnant women, sFasL fell from week 15 to week 29 (P < .03). We conclude that sFas and sFasL is unchanged in nor... Angiology journals http://www.medworm.com/rss/comments.php?id=5476293 Sun, 04 Dec 2011 05:00:00 +0100 5476293 http://www.medworm.com/index.php?rid=5476292&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F1%2F30%3Frss%3D1 High-sensitivity CRP (hsCRP) is being increasingly used as a marker for cardiac risk assessment and as a prognostic tool in acute coronary syndrome. We analyzed the relation between hsCRP values at admission and in-hospital outcomes in 98 consecutive patients with acute myocardial infarction (AMI) undergoing catheterization. Patients with cardiac events had more advanced Killip class, more proportion of depressed left ventricular ejection fraction (LVEF), higher Global Registry of Acute Coronary Events (GRACE) risk score, and higher hsCRP levels. High-sensitivity CRP and GRACE risk score showed a significant positive correlation (r = .320, P = .002). In multivariate analysis, hsCRP resulted as a predictor of worse in-hospital outcomes independently of GRACE risk score (OR 1.122, CI95%:1.00... Angiology journals http://www.medworm.com/rss/comments.php?id=5476292 Sun, 04 Dec 2011 05:00:00 +0100 5476292 http://www.medworm.com/index.php?rid=5476291&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F1%2F24%3Frss%3D1 We evaluated the relationship between admission white blood cell (WBC) count and in-hospital outcomes in acute coronary syndrome (ACS) patients from the Middle East. Data were analyzed from 7806 consecutive patients with ACS who were divided into 4 groups (G) according to their WBC count (x109/L; G1: <6.00; G2: 6.00-9.99; G3: 10.00-11.99; G4: ≥12.00). After significant covariate adjustment, those in G4 were 68% more likely to have cardiogenic shock than those in G1 (95% confidence interval [CI]: 1.05-2.68; P = .030) and G2 (odds ratio [OR], 2.02; 95% CI: 1.51-2.71; P < .001). Those in G4 were 2.02 times (95% CI: 1.11-3.67; P = .021) and 65% (95% CI: 1.17-2.32; P = .004) more likely to die in hospital than those in G1 and G2, respectively. Admission WBC count is an independent risk... Angiology journals http://www.medworm.com/rss/comments.php?id=5476291 Sun, 04 Dec 2011 05:00:00 +0100 5476291 http://www.medworm.com/index.php?rid=5476290&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F1%2F17%3Frss%3D1 Coronary heart disease (CHD) is the leading cause of mortality in the industrialized world and that might also soon be the case in other parts of the world. There are several easily measured and potentially modifiable risk factors that account for a substantial proportion of the risk of CHD. The effect of risk factors interventions appears to be consistent in both genders, across different geographic regions, and by all ethnic groups, suggesting that approaches to prevention can be based on similar principles worldwide. Optimal target levels for serum cholesterol and blood pressure are not yet clear. Future risk CHD reduction will mainly be achieved by improved primary prevention. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5476290 Sun, 04 Dec 2011 05:00:00 +0100 5476290 http://www.medworm.com/index.php?rid=5476289&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F63%2F1%2F12%3Frss%3D1 In conclusion, serum Hsp-27 concentrations are elevated in the early hours following ACS, but fall to levels near to those in healthy individuals after about 12 hours from the onset of chest pain. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5476289 Sun, 04 Dec 2011 05:00:00 +0100 5476289 http://www.medworm.com/index.php?rid=5476288&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F63%2F1%2F9%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5476288 Sun, 04 Dec 2011 05:00:00 +0100 5476288 http://www.medworm.com/index.php?rid=5476287&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F63%2F1%2F5%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5476287 Sun, 04 Dec 2011 05:00:00 +0100 5476287 http://www.medworm.com/index.php?rid=5304202&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F8%2F662%3Frss%3D1 Cardiovascular remodeling in chronic kidney disease (CKD) is responsible for the high mortality found in this condition. A total of 89 consecutive outpatients with stage III CKD and 52 patients with stage II CKD with similar degree of traditional atherosclerotic risk factors underwent routine echocardiographic and carotid Doppler examination, evaluating vascular and cardiac remodeling (intima—media thickness [IMT] and left ventricular mass index [LVMi]), and its relation with arterial stiffness, determined in the same examination, using an echo-tracking technique. Also the absolute values of LVMi and IMT were statistically similar between the 2 groups, their determinants were completely different, only in stage III the markers of renal impairment and arterial stiffness being independ... Angiology journals http://www.medworm.com/rss/comments.php?id=5304202 Tue, 11 Oct 2011 04:00:00 +0100 5304202 http://www.medworm.com/index.php?rid=5304201&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F8%2F657%3Frss%3D1 We compared the prevalence and management of metabolic syndrome (MetS) and its components in men and women with peripheral artery disease (PAD). A total of 70 men and 70 women with PAD were evaluated for presence of MetS. There was no significant gender difference in presence of MetS (P = .399) and the number of MetS components (P = .411). Among PAD patients with each MetS component, there was no significant gender difference in the use (P = .617) and number (P = .716) of blood pressure medications, the use (P = .593) and number (P = .591) of lipid-lowering medications, and the number (P = .155) of diabetic medications. Significantly more women were treated with diabetic medications compared with men (85 vs 57%, P = .026). The prevalence and management of MetS and its components was simila... Angiology journals http://www.medworm.com/rss/comments.php?id=5304201 Tue, 11 Oct 2011 04:00:00 +0100 5304201 http://www.medworm.com/index.php?rid=5304200&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F8%2F645%3Frss%3D1 The present study was carried out to provide information about outcome of the Jetstream atherectomy device for treatment of infrainguinal arteries. From February 2006 to February 2007, 172 patients with Rutherford class 1 to 5 lower limb ischemia were enrolled at 9 study sites. The endpoints were evaluation of quality of life according to the walking impairment questionnaire (WIQ) besides technical parameters. In the total study cohort, the WIQ scale maintained improved up to 12-month follow-up. Furthermore, target lesion revascularization rate was 26% (42/162), ankle-brachial index (ABI) increased from 0.59 ± 0.21 at baseline to 0.82 ± 0.27 (P < 0.05), and mean Rutherford class dropped from 3.0 ± 0.9 at baseline to 1.5 ± 1.3 at 1 year (P < .05). The resul... Angiology journals http://www.medworm.com/rss/comments.php?id=5304200 Tue, 11 Oct 2011 04:00:00 +0100 5304200 http://www.medworm.com/index.php?rid=5304199&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F8%2F641%3Frss%3D1 This review is specifically designed to aid the vascular surgeon in the management of heparin-induced thrombocytopenia (HIT). Heparin-induced thrombocytopenia is a rare complication of heparin administration, which poses significant morbidity and mortality. Its onset is usually 5 to 10 days after the heparin administration and should be suspected if platelet counts drop by at least 50%. Confirmation is given by the presence of HIT antibodies on an enzyme-linked immunosorbent assay (ELISA) or in functional platelet activation assays. The major complication is thrombosis and surprisingly bleeding is rare. Heparin must be stopped immediately if there is a clinical suspicion of HIT and alternative anticoagulation must be started. Anticoagulation is required for at least 2 to 3 months to preven... Angiology journals http://www.medworm.com/rss/comments.php?id=5304199 Tue, 11 Oct 2011 04:00:00 +0100 5304199 http://www.medworm.com/index.php?rid=5304198&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F8%2F636%3Frss%3D1 In conclusion, switching to MUFA-rich diets or substituting half of the SAFAs with MUFAs can reverse diet-induced-hypercholesterolemia. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5304198 Tue, 11 Oct 2011 04:00:00 +0100 5304198 http://www.medworm.com/index.php?rid=5304197&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F8%2F625%3Frss%3D1 Conclusion: Despite significant improvement in the neuropathy symptom scores in the overall motor and sensory categories of the 3 arms of the study from baseline to week 12, no significant differences were found among the groups, indicating nonsuperiority of cilostazol in regard to improvement of neuropathy symptoms over the short study span. However, cilostazol, at low dose, was effective in improving walking speed from baseline to week 12, implying an improved blood flow. No significant worsening nor improvement in motor and sensory nerve conduction parameters were observed, comparing the 3 study arms from baseline to weeks 4, 12, and 16, supporting cilostazol’s safety. Overall, the adverse events of the 3 study arms did not significantly differ, and neither were there serious adve... Angiology journals http://www.medworm.com/rss/comments.php?id=5304197 Tue, 11 Oct 2011 04:00:00 +0100 5304197 http://www.medworm.com/index.php?rid=5304196&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F8%2F620%3Frss%3D1 The number of percutaneous coronary interventions (PCI) performed for octogenarians with acute coronary syndrome (ACS) continue to increase. The short- and long-term outcomes of intravascular ultrasound (IVUS)-guided PCI with drug-eluting stents (DES) or bare metal stents (BMS) for ACS in octogenarians, however, remain largely unknown. We analyzed clinical outcomes of octogenarians undergoing IVUS-guided PCI for ACS with either DES or BMS. During the study period, a total of 776 patients with ACS underwent IVUS-guided PCI and 75 of them were octogenarians. In-hospital mortality tended to be lower in the DES group than in the BMS group. Between 6 months and 1 year of follow up, treatment with DES compared with BMS tended to result in fewer target lesion revascularizations. Major adverse car... Angiology journals http://www.medworm.com/rss/comments.php?id=5304196 Tue, 11 Oct 2011 04:00:00 +0100 5304196 http://www.medworm.com/index.php?rid=5304195&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F8%2F614%3Frss%3D1 There is growing clinical interest in liver transaminases as novel biomarkers of cardiovascular risk. We investigated the possible association of serum liver transaminase activity with the presence and angiographic severity of premature coronary artery disease (CAD). A cross-sectional study was conducted on 187 younger patients (females <55 years and males <45 years) who underwent coronary angiography and had serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and high-sensitivity C-reactive protein (hsCRP) measured. Evaluation of coronary stenosis was by Gensini score. Both ALT and AST were significantly correlated with the presence of CAD in univariate and multivariate analyses. Both ALT and AST were also significantly correlated with Gensini score even after ad... Angiology journals http://www.medworm.com/rss/comments.php?id=5304195 Tue, 11 Oct 2011 04:00:00 +0100 5304195 http://www.medworm.com/index.php?rid=5304194&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F8%2F609%3Frss%3D1 Perioperative complications from carotid endarterectomy (CEA) are the main drawbacks of the procedure. The aim of this study was to assess the complication rates in patients undergoing CEA under general anesthesia (GA) or regional anesthesia (local anesthesia [LA]) at our institution. Patients undergoing CEA at our regional vascular unit between 2000 and 2004 were included. Data were collated retrospectively from a prospective database. Follow-up was up to 62 months. In all, 383 endarterectomies were performed, 260 of which were under LA. Outcome measures included 30-day death (2.1%), stroke (1.8%), and combined stroke and death (2.8%). A 30-day incidence of stroke, death, and combined stroke and death was lower in the LA group. Incidence of myocardial infarction and transient ischemic att... Angiology journals http://www.medworm.com/rss/comments.php?id=5304194 Tue, 11 Oct 2011 04:00:00 +0100 5304194 http://www.medworm.com/index.php?rid=5304193&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F8%2F605%3Frss%3D1 Peripheral neuropathy remains a major chronic complication of diabetes mellitus. Its pathogenesis mainly involves chronic glucose toxicity and nerve ischemia. Preclinical studies have shown that cilostazol, a reversible selective inhibitor of phosphodiesterase-3A with antiplatelet, antithrombotic, and vasodilatory properties, exerts beneficial effects on nerve function in experimental diabetes. Clinical data, however, is sparse. Two recent randomized placebo-controlled clinical trials showed that cilostazol did not improve diabetic neuropathy in humans. Hence, more data is needed to confirm or refute the poor clinical efficacy of cilostazol. Importantly, future studies should include larger patient series, provide longer follow-up data, and employ more accurate diagnostic tools. (Source: A... Angiology journals http://www.medworm.com/rss/comments.php?id=5304193 Tue, 11 Oct 2011 04:00:00 +0100 5304193 http://www.medworm.com/index.php?rid=5304192&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F8%2F601%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5304192 Tue, 11 Oct 2011 04:00:00 +0100 5304192 http://www.medworm.com/index.php?rid=5304191&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F8%2F597%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5304191 Tue, 11 Oct 2011 04:00:00 +0100 5304191 http://www.medworm.com/index.php?rid=5296736&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F7%2F590%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5296736 Fri, 07 Oct 2011 04:00:00 +0100 5296736 http://www.medworm.com/index.php?rid=5296735&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F7%2F588%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5296735 Fri, 07 Oct 2011 04:00:00 +0100 5296735 http://www.medworm.com/index.php?rid=5296734&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F7%2F585%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5296734 Fri, 07 Oct 2011 04:00:00 +0100 5296734 http://www.medworm.com/index.php?rid=5296733&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F7%2F579%3Frss%3D1 In conclusion, the improvement of vascular outcomes due to secondary prevention measures and technological advances in the management of acute vascular events may result in a relative increase in cancer incidence and deaths. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5296733 Fri, 07 Oct 2011 04:00:00 +0100 5296733 http://www.medworm.com/index.php?rid=5296732&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F7%2F571%3Frss%3D1 Lipid lowering with statins improves morbidity and mortality, particularly in diabetics, and may have additional nonlipid effects. South Asians (SAs) are at higher risk of cardiovascular disease and diabetes compared with white Europeans (WEs). We hypothesized that abnormal endothelial (marked by von Willebrand factor), angiogenesis (VEGF, angiopoietins 1 and 2) and platelet function (soluble P selectin, soluble CD40L) improve with statin treatment in diabetics in different ethnic groups. Plasma was obtained before and 8 weeks after treatment with atorvastatin (80 mg/day) by SAs and WEs with or without diabetes. Research indices were measured by enzyme-linked-immunosorbent assay (ELISA). Treatment increased angiopoietin-2 (P < .04) in all groups regardless of diabetes or ethnicity. In t... Angiology journals http://www.medworm.com/rss/comments.php?id=5296732 Fri, 07 Oct 2011 04:00:00 +0100 5296732 http://www.medworm.com/index.php?rid=5296731&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F7%2F565%3Frss%3D1 We determined whether arterial compliance measured by pulse wave analysis is impaired in obese pubertal children compared to normal weight controls, and assessed whether arterial compliance is associated with ambulatory activity. Body fat percentage was significantly different between the normal (n = 33) and obese (n = 34) participants (P < .001). Large (P = .012) and small (P < .001) arterial compliance were lower in the normal-weight group. After adjusting for height, systolic and diastolic blood pressure, race, sex, and Tanner stage, large arterial compliance was no longer different between groups (P = .066), whereas small arterial compliance remained higher in the obese group (P < .001). Obese pubertal children have paradoxically increased small arterial compliance compared to... Angiology journals http://www.medworm.com/rss/comments.php?id=5296731 Fri, 07 Oct 2011 04:00:00 +0100 5296731 http://www.medworm.com/index.php?rid=5296730&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F7%2F554%3Frss%3D1 The pathogenesis of coronary artery calcification and its role in atherogenesis has not been completely understood but is a new focus of interest in experimental and clinical research. Various bioactive substances, including hormones, have been implicated in the process of arterial calcification. This review considers the relationship between coronary artery calcification and hormones. These hormones may become therapeutic targets for the prevention of arterial calcification. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5296730 Fri, 07 Oct 2011 04:00:00 +0100 5296730 http://www.medworm.com/index.php?rid=5296729&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F7%2F549%3Frss%3D1 In this study, we investigated the role of the -174G>C polymorphism of interleukin-6 (IL-6) as a predisposing factor to angina pectoris. Patients were separated into 2 groups: angina (N = 72) and nonangina (N = 71). There were no statistical differences between groups for all cardiovascular risk factors evaluated. The GG genotype frequency was 18% lower in the angina than in the non-angina group, whereas GC + CC was 18% higher in the angina group (P = .036). The frequency of G allele was 11% lower in the angina than in the nonangina group and C allele was 11% higher in the angina group (P = .043). Patients carrying the C allele showed a 2-fold increased risk for angina pectoris (P = .036). Our study demonstrates a high incidence of the -174G>C polymorphism of the IL-6 gene in patient... Angiology journals http://www.medworm.com/rss/comments.php?id=5296729 Fri, 07 Oct 2011 04:00:00 +0100 5296729 http://www.medworm.com/index.php?rid=5296728&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F7%2F543%3Frss%3D1 In conclusion, patients with PCOS had increased nondipping ratios and cIMT when compared with controls. Insulin resistance and LDL cholesterol are factors that are related to diurnal variation in normotensive and young patients with PCOS. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5296728 Fri, 07 Oct 2011 04:00:00 +0100 5296728 http://www.medworm.com/index.php?rid=5296727&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F7%2F535%3Frss%3D1 The role of inflammation is well established in the pathogenesis of atherosclerosis and an increased level of circulating inflammatory markers may predict the future risk of atherosclerosis progression and plaque rupture. C-reactive protein (CRP) identification by hypersensitive methods (high-sensitivity CRP [hsCRP]) has become a clinical and laboratory inflammation marker. Carotid endarterectomy (CEA) is a well-established procedure for carotid stenosis treatment which can reduce stroke rate. Internal carotid artery (ICA) restenosis reduction may be prevented by the anti-inflammatory effect of statins. This review considers the recent findings on the presence of hsCRP and C3 complement concentration and inflammatory plaque composition as well as their effects on ICA restenosis rate, follo... Angiology journals http://www.medworm.com/rss/comments.php?id=5296727 Fri, 07 Oct 2011 04:00:00 +0100 5296727 http://www.medworm.com/index.php?rid=5296726&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F7%2F523%3Frss%3D1 The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPARα, -, and -/β, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in t... Angiology journals http://www.medworm.com/rss/comments.php?id=5296726 Fri, 07 Oct 2011 04:00:00 +0100 5296726 http://www.medworm.com/index.php?rid=5296725&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F7%2F520%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5296725 Fri, 07 Oct 2011 04:00:00 +0100 5296725 http://www.medworm.com/index.php?rid=5296724&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F7%2F517%3Frss%3D1 The term quality of life can be identified in Aristotle's classical writings of 330 BC. In his Nichomachian ethics he recognises the multiple relationships between happiness, well-being, "eudemonia" and quality of life. Historically the concept of quality of life has undergone various interpretations. It involves personal experience, perceptions and beliefs, attitudes concerning philosophical, cultural, spiritual, psychological, political, and financial aspects of everyday living. Quality of life has been extensively used both as an outcome and an explanatory factor in relation to human health, in various clinical trials, epidemiologic studies and health interview surveys. Because of the variations in the definition of quality of life, both in theory and in practice, there are also a wide ... Angiology journals http://www.medworm.com/rss/comments.php?id=5296724 Fri, 07 Oct 2011 04:00:00 +0100 5296724 http://www.medworm.com/index.php?rid=5063482&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F6%2F509%3Frss%3D1 In conclusion, this study suggests that PA has an important role in controlling MetS. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5063482 Sat, 23 Jul 2011 23:00:00 +0100 5063482 http://www.medworm.com/index.php?rid=5063481&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F6%2F504%3Frss%3D1 Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease and death. We evaluated the association between CKD and severity of coronary artery stenosis by calculating SYNTAX Score in patients with left main coronary artery and/or 3-vessel coronary artery disease. Coronary angiograms of 217 patients were assessed. Chronic kidney disease was staged using the estimated glomerular filtration rate (eGFR, mL/min per 1.73 m2) prior to coronary angiography. Patients were divided into 5 groups according to the National Kidney Foundation Kidney Disease Outcome Quality Initiative (NKF KDOQI) Clinical Practice Guidelines (14). Patients with eGFR >90 mL/min per 1.73 m2 (group 1), patients with eGFR 60 to 89 mL/min per 1.73 m2 (group 2), patients with eGFR 30 to 59 mL/mi... Angiology journals http://www.medworm.com/rss/comments.php?id=5063481 Sat, 23 Jul 2011 23:00:00 +0100 5063481 http://www.medworm.com/index.php?rid=5063480&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F6%2F500%3Frss%3D1 This study may lead to identifying those small AAAs that could justify early endovascular intervention. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5063480 Sat, 23 Jul 2011 23:00:00 +0100 5063480 http://www.medworm.com/index.php?rid=5063479&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F6%2F490%3Frss%3D1 Peripheral arterial disease (PAD) is a common manifestation of atherosclerotic vascular disease and the incidence of infrapopliteal PAD continues to rise in the population. The historical experience with surgical and endovascular interventions for infrapopliteal stenosis was disappointing as operators experienced high rates of early technical failures and procedural complications, coupled with high rates of restenosis in this vascular territory when compared with more proximal vascular beds. While patients with infrapopliteal PAD may be asymptomatic, the majority would ultimately develop intermittent claudication or may also present with critical limb ischemia. In this article, we review the current literature, and discuss some of the technical aspects of endovascular therapy in this vascu... Angiology journals http://www.medworm.com/rss/comments.php?id=5063479 Sat, 23 Jul 2011 23:00:00 +0100 5063479 http://www.medworm.com/index.php?rid=5063478&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F6%2F473%3Frss%3D1 We used the National Heart, Lung, and Blood Institute Limited Access Dataset of Prevention of Events with Angiotensin-Converting Enzyme Inhibition (PEACE) Trial (n = 8290) which included patients with stable coronary artery disease (CAD) and preserved ejection fraction (>40%). We identified risk factors for the development of critical peripheral arterial disease (PAD; those needing angioplasty, bypass grafting, or aneurysm repair) and formulated a risk score by multivariate analyses. A total of 220 patients (2.8%) developed critical PAD over a mean follow-up of 4.7 years. Significant predictors of critical PAD were history of intermittent claudication, smoking, hypertension (HTN), coronary-artery bypass grafting (CABG), diabetes, age, serum cholesterol, and body mass index (BMI). Incide... Angiology journals http://www.medworm.com/rss/comments.php?id=5063478 Sat, 23 Jul 2011 23:00:00 +0100 5063478 http://www.medworm.com/index.php?rid=5063477&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F6%2F467%3Frss%3D1 Conclusions: Collateral circulation was associated with telomere shortening and elevation of CRP levels. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5063477 Sat, 23 Jul 2011 23:00:00 +0100 5063477 http://www.medworm.com/index.php?rid=5063476&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F6%2F461%3Frss%3D1 We compared exercise performance, daily physical activity, and health-related quality of life in 115 participants with stable angina and 441 controls without coronary artery disease or stable angina. Participants with stable angina had shorter 6-min walk distance (P = .003), and lower total leisure-time physical activity (P = .003) than the controls. Group differences in these measures remained (P < .05) after adjusting for age, race, current smoking, diabetes, hypertension, and obesity. Participants with stable angina also had lower health-related quality of life for physical function (P < .001), general health (P = .002), and vitality (P < .001), but group differences did not remain (P > .05) after adjustment for comorbid conditions. Participants with stable angina have impai... Angiology journals http://www.medworm.com/rss/comments.php?id=5063476 Sat, 23 Jul 2011 23:00:00 +0100 5063476 http://www.medworm.com/index.php?rid=5063475&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F6%2F457%3Frss%3D1 The Carotid Disease and Cardiac Surgery Consensus Meeting was convened as a multidisciplinary gathering to consider the management of patients undergoing cardiac surgery who are found to have asymptomatic carotid artery disease. There are no randomized trials concerning whether carotid interventions are of value in this situation and the natural history is unclear. Bilateral carotid artery disease (≥70% stenosis) should be regarded clinically relevant when considering hemodynamic and short-term surgical stroke risk. However, this may be because the presence of significant carotid disease is also a marker for aortic arch and intracerebral disease. A natural history study is urgently needed to determine the incidence, predictive factors, and natural history of asymptomatic carotid disease... Angiology journals http://www.medworm.com/rss/comments.php?id=5063475 Sat, 23 Jul 2011 23:00:00 +0100 5063475 http://www.medworm.com/index.php?rid=5063474&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F6%2F455%3Frss%3D1 The management of asymptomatic carotid artery stenosis (CAS) has been the subject of extensive debate. Current evidence suggests that the annual risk of stroke in patients with CAS and without previous cerebrovascular symptoms is 1% which makes carotid endarterectomy unjustifiable. Conservative treatment with statins and antiplatelets, the identification of the high risk individuals as well as aggressive life style modifications are considered sufficient measures for the protection of these patients. However, there are reasons to believe that this approach may be less effective than we think. Best medical treatment is only effective when compliance is adequate and lipid or blood pressure target levels are achieved. However this is not always the case and the same applies regarding life sty... Angiology journals http://www.medworm.com/rss/comments.php?id=5063474 Sat, 23 Jul 2011 23:00:00 +0100 5063474 http://www.medworm.com/index.php?rid=5063473&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F6%2F447%3Frss%3D1 We evaluated the use of quadruple evidence-based medication (EBM) combination consisting of antiplatelet therapy, angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker, β-blocker, and lipid-lowering agent concurrently at discharge among patients (n = 8154) with acute coronary syndrome (ACS) in 6 Middle Eastern countries. In all, 49% of the patients received the quadruple EBM combination concurrently at discharge. An adjusted model demonstrated that old age, diabetes mellitus, hyperlipidemia, hypertension, ST-segment elevation myocardial infarction, cardiac catheterization, as well as cardiologists as care providers and hospitals with cardiac catheterization facilities were all positively correlated with the use of the quadruple EBM combination. However, patients w... Angiology journals http://www.medworm.com/rss/comments.php?id=5063473 Sat, 23 Jul 2011 23:00:00 +0100 5063473 http://www.medworm.com/index.php?rid=5063472&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F6%2F440%3Frss%3D1 Metabolic syndrome (MetS) is regarded as a risk factor for coronary artery disease (CAD). However, the influence of MetS on morbidity and mortality after drug-eluting stent (DES) implantation in Chinese patients with CAD remains unknown. We evaluated the impact of MetS on the clinical outcome of 1224 patients following DES implantation. After a mean follow-up of 35.4 months, patients with MetS had a significantly higher incidence of all-cause death and major adverse cardiovascular events (MACE) compared with patients without MetS (P < .001). Analyses of individual MetS components showed that dysglycemia at the time of DES implantation predicted increased all-cause mortality, while the presence of hypertension and dysglycemia predicted increased incidence of MACE. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5063472 Sat, 23 Jul 2011 23:00:00 +0100 5063472 http://www.medworm.com/index.php?rid=5063471&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F6%2F437%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=5063471 Sat, 23 Jul 2011 23:00:00 +0100 5063471 http://www.medworm.com/index.php?rid=4842729&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F5%2F422%3Frss%3D1 We assessed the role of lead and cadmium as partial mediators between smoking and composite cardiovascular and cerebrovascular disease (CCVD). We also studied the association between urinary heavy metals and CCVD. Pooled data from NHANES 1999-2006 were examined. Cardiovascular and cerebrovascular disease was determined using a standardized questionnaire asking about history of stroke, angina, heart attack, coronary artery disease, and congestive heart failure. Increasing serum cadmium levels were associated with increasing prevalence of CCVD (P-trend: .03). Adjusted odds-ratio (OR) for active smokers versus never smokers was 2.09 (1.67-2.63). Adjustment for lead did not affect the OR but adjustment for cadmium significantly attenuated the OR (1.54 [1.17-2.03]). Significant association was ... Angiology journals http://www.medworm.com/rss/comments.php?id=4842729 Tue, 17 May 2011 23:00:00 +0100 4842729 http://www.medworm.com/index.php?rid=4842728&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F5%2F415%3Frss%3D1 High cardiovascular risk patients need reduction of low-density-lipoprotein cholesterol (LDL-C) to <70 mg/dL (1.8 mmol/L). Statins are optimal treatment but myopathy can be a limitation to their use. The incidence of statin-related myopathy is difficult to determine but up to 10.5% appears an appropriate estimate. Short-term trials report lower incidence than long-term trials. Statin-related myopathy may be influenced by genetics and tends to be dose-dependent. Ezetimibe can contribute to LDL-C reduction allowing a lower dose of statin to be used. Another approach is to administer rosuvastatin twice weekly. Statins have been shown to interfere with the cellular role of coenzyme Q10. Coenzyme Q10 supplementation may decrease or prevent statin myopathy, but this has not been proven. The o... Angiology journals http://www.medworm.com/rss/comments.php?id=4842728 Tue, 17 May 2011 23:00:00 +0100 4842728 http://www.medworm.com/index.php?rid=4842727&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F5%2F409%3Frss%3D1 In conclusion: UA and LA occlusion decrease PWV maximally at 1 minute after release of arterial occlusion. PWV 1 min decline are more marked after UA than LA occlusion and progressively lessens with increasing Framingham risk. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4842727 Tue, 17 May 2011 23:00:00 +0100 4842727 http://www.medworm.com/index.php?rid=4842726&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F5%2F401%3Frss%3D1 Cardio-ankle vascular index (CAVI) using the volume plethysmographic method is a noninvasive atherosclerotic indicator which is not influenced by blood pressure. Coronary intravascular ultrasound (IVUS) is a reliable technique to measure progression of atherosclerosis. The association between CAVI and IVUS has not been reported. The aim of this study was to evaluate the association between CAVI and the plaque burden measured by IVUS in the left main coronary artery (LMCA) in patients with coronary heart disease and normal LMCA. Cardio-ankle vascular index was significantly correlated with percentage plaque area (r = .649, P < .0001) measured by IVUS in the most diseased segment of LMCA. Cardio-ankle vascular index remained significant among cardiovascular disease risk factors included i... Angiology journals http://www.medworm.com/rss/comments.php?id=4842726 Tue, 17 May 2011 23:00:00 +0100 4842726 http://www.medworm.com/index.php?rid=4842725&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F5%2F397%3Frss%3D1 There is little information about coronary artery endothelial dysfunction in patients with sleep apnea. We evaluated relation between severity of sleep apnea and coronary artery endothelial dysfunction. In all, 26 patients without significant coronary stenoses were enrolled. Endothelial function was estimated by measuring coronary vasoreactivity in response to acetylcholine infusion (10-7 mol/L) into coronary arteries. Vasoconstriction rate was defined as ([lumen diameter after isosorbide dinitrate injection - lumen diameter after acetylcholine injection]/lumen diameter after isosorbide dinitrate injection x 100). Vasoconstriction rate was calculated at each major coronary artery and the highest value was used for that patient. Overnight sleep study was performed and the apnea-hypopnea ind... Angiology journals http://www.medworm.com/rss/comments.php?id=4842725 Tue, 17 May 2011 23:00:00 +0100 4842725 http://www.medworm.com/index.php?rid=4842724&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F5%2F390%3Frss%3D1 Our objective was to validate the Global Registry of Acute Coronary Events (GRACE) risk score for in-hospital mortality in a Middle Eastern acute coronary syndrome (ACS) population enrolled in the Gulf Registry of Acute Coronary Events (Gulf RACE). Out of 8176, unselected, consecutive patients with ACS, during 6 months in 2006 and 2007 from 63 hospitals in 6 Arab countries in the Middle East Gulf region, 7709 (94.3%) with available data were included. The main outcome measures were discriminatory performance (using C-index) and calibration of the GRACE risk score (in-hospital mortality predicted by GRACE risk score versus the actual mortality). In-hospital mortality in the Gulf RACE was 3.09% (n = 238). The discriminatory performance of the GRACE risk scores in the Gulf RACE was good overa... Angiology journals http://www.medworm.com/rss/comments.php?id=4842724 Tue, 17 May 2011 23:00:00 +0100 4842724 http://www.medworm.com/index.php?rid=4842723&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F5%2F381%3Frss%3D1 We evaluated in-hospital outcomes of acute coronary syndrome (ACS) patients with metabolic syndrome (MetS) in Oman. We analyzed the records of 1392 patients admitted with a diagnosis of ACS as part of the Gulf Registry of Acute Coronary Events. The prevalence of MetS among patients with ACS was 66%, with female preponderance (80% vs 57%; P < .001). MetS was associated with several characteristics including diabetes (45% vs 19%; P < .001), hyperlipidemia (40% vs 23%; P < .001), hypertension (62% vs 34%; P < .001), renal impairment (9.3% vs 3.4%; P < .001), Killip score > II (13% vs 8%; P = .004), and non-ST segment elevation myocardial infarction (78% vs 68%; P < .001). After multivariate adjustment, MetS was associated with higher risk of in-hospital heart failure (odd... Angiology journals http://www.medworm.com/rss/comments.php?id=4842723 Tue, 17 May 2011 23:00:00 +0100 4842723 http://www.medworm.com/index.php?rid=4842722&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F5%2F376%3Frss%3D1 Serum levels of S-100B and neurone-specific enolase (NSE) reflect cerebral injury in a variety of neurological conditions such as stroke, traumatic brain injury, and cardiac arrest. There are limited data on the release of S-100B and NSE following carotid artery stenting (CAS). In 22 patients undergoing CAS, serial blood samples for S-100B and NSE were collected before and 2, 4, and 6 to 8 hours after the procedure. A group of 20 patients with significant CAS undergoing purely diagnostic angiography served as controls. A significant increase in S-100B levels was observed 2 hours after the procedure in patients with CAS (P = .001) with a gradual decline over the next hours. In contrast, patients who underwent purely diagnostic angiography did not show significant changes in S-100B levels up... Angiology journals http://www.medworm.com/rss/comments.php?id=4842722 Tue, 17 May 2011 23:00:00 +0100 4842722 http://www.medworm.com/index.php?rid=4842721&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F5%2F372%3Frss%3D1 We report findings from 14 surgical patients undergoing carotid artery reconstruction for symptomatic cerebrovascular disease. All of them had fluorescein angiography (FA) of the eye ipsilateral to the carotid operation before surgery and 3 months after to provide information regarding retinal circulation time. Before the surgical procedure, the mean circulation time was 29.4 ± 9.4 seconds (CI 95%: 24.5-34.3). After 3 months, a significant (P < .001) decrease in the circulation time was observed: 18.9 ± 8.4 seconds (CI 95%: 14.5-23.4). The present series demonstrates that carotid revascularization surgery improved retinal flow in approximately 80% of the patients. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4842721 Tue, 17 May 2011 23:00:00 +0100 4842721 http://www.medworm.com/index.php?rid=4842720&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F5%2F365%3Frss%3D1 This study shows that foot amputees have high mortality and reintervention rates. Adequate utilization of vascular services, extra vigilance in the prevention of complications, and risk factor modifications are required to improve postoperative outcomes. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4842720 Tue, 17 May 2011 23:00:00 +0100 4842720 http://www.medworm.com/index.php?rid=4842719&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F5%2F359%3Frss%3D1 Conclusion: Endovascular treatment of BTK lesions represents a safe and effective treatment option to patients with CLI. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4842719 Tue, 17 May 2011 23:00:00 +0100 4842719 http://www.medworm.com/index.php?rid=4686033&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F4%2F352%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4686033 Tue, 05 Apr 2011 23:00:00 +0100 4686033 http://www.medworm.com/index.php?rid=4686032&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F4%2F350%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4686032 Tue, 05 Apr 2011 23:00:00 +0100 4686032 http://www.medworm.com/index.php?rid=4686031&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F4%2F349%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4686031 Tue, 05 Apr 2011 23:00:00 +0100 4686031 http://www.medworm.com/index.php?rid=4686030&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F4%2F346%3Frss%3D1 We herein report a case of a thalassemic-patient who was on deferasirox chelation therapy and admitted to the emergency department because of fever, diffuse abdominal pain and altered mental status. Despite the appropriate treatment he died two days later due to cardiac arrest. As we failed to recognize any etiology and the patients’ relatives denied a post mortem examination due to religious reasons, we cannot provide any additional data. However, we are wondering whether this incident might be related to deferasirox. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4686030 Tue, 05 Apr 2011 23:00:00 +0100 4686030 http://www.medworm.com/index.php?rid=4686029&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F4%2F344%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4686029 Tue, 05 Apr 2011 23:00:00 +0100 4686029 http://www.medworm.com/index.php?rid=4686028&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F4%2F338%3Frss%3D1 Vascular involvement in systemic sclerosis (SSc) plays a key role in the pathogenesis of fibrosis. We assessed arterial stiffness using a new echo-tracking technique in patients with SSc asymptomatic for cardiovascular diseases. We enrolled 22 patients (21 female, 63 ± 14 years) and 20 controls (12 female, 62 ± 3 years). Carotid intima-media thickness (IMT) was comparable between the 2 groups (1.1 ± 0.3 vs 1.0 ± 0.4 mm, P = ns), whereas the stiffness parameters were significantly increased in patients (β: 9.5 ± 4.2 vs 5.8 ± 1.1, P = .001; pulse wave velocity [PWV]: 6.5 ± 1.5 vs 5.2 ± 0.6 m/sec, P = .003). A correlation between stiffness parameters, anti-Scl-70 antibodies (β: r = .46, P = .03; PWV: r = .50, P = .02), and anti... Angiology journals http://www.medworm.com/rss/comments.php?id=4686028 Tue, 05 Apr 2011 23:00:00 +0100 4686028 http://www.medworm.com/index.php?rid=4686027&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F4%2F329%3Frss%3D1 The aim of the study was to test Turkish validity and reliability of Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms (VEINES-QoL/Sym) in patients with chronic venous insufficiency (CVI). A total of 118 patients with CVI hospitalized in 3 different hospitals were enrolled in this study. VEINES-QoL/Sym, translated to Turkish with a standard methodology, was applied to the patients and was evaluated for acceptability, reliability, validity, and responsiveness. Cronbach α (including if item deleted) values were used for the reliability analysis. Construct and criterion validity approaches were used for validity analysis. Cronbach α values are .86 for the VEINES-QOL and .81 for the VEINES-Sym. No problematic items were observed for the scale. The VEI... Angiology journals http://www.medworm.com/rss/comments.php?id=4686027 Tue, 05 Apr 2011 23:00:00 +0100 4686027 http://www.medworm.com/index.php?rid=4686026&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F4%2F317%3Frss%3D1 We estimated the value of objective, computerized texture analysis of ultrasonic images in distinguishing carotid plaques associated with neurological ipsilateral symptoms (amaurosis fugax [AmF; n = 30], transient ischemic attack [TIA; n = 52], and stroke [n = 55]) from asymptomatic plaques (n = 51). We performed 3 case-control studies (1/symptom with asymptomatic plaques as control). On logistic regression, AmF was independently associated with severity of stenosis, percentage of pixels with gray levels 0 to 10 (PPCS1; measure of echolucency), and spatial gray level dependence matrices (SGLDM) information measure of correlation (IMC-1; texture); TIAs with PPCS1 (echolucency), SGLDM correlation, and skewness (both texture); and stroke with PPCS1, SGLDM correlation, and percentage of pixels... Angiology journals http://www.medworm.com/rss/comments.php?id=4686026 Tue, 05 Apr 2011 23:00:00 +0100 4686026 http://www.medworm.com/index.php?rid=4686025&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F4%2F310%3Frss%3D1 Conclusions: Atrial volume was related to AF recurrence, whereas hsCRP, IL-6, and NTpro-BNP were not reliable for AF relapse. Relation of NTpro-BNP to left atrial volume could indicate a role in the atrial remodeling process. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4686025 Tue, 05 Apr 2011 23:00:00 +0100 4686025 http://www.medworm.com/index.php?rid=4686024&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F4%2F306%3Frss%3D1 In conclusion, PAD patients having DM and using cilostazol had less LEA or PRP, whereas those having HTN and CAD had more LEA or PRP. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4686024 Tue, 05 Apr 2011 23:00:00 +0100 4686024 http://www.medworm.com/index.php?rid=4686023&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F4%2F301%3Frss%3D1 In conclusion, 8 weeks of ET in patients with PAD reduces plasma levels of the specific endothelium-derived inflammatory markers E-selectin and ICAM-1. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4686023 Tue, 05 Apr 2011 23:00:00 +0100 4686023 http://www.medworm.com/index.php?rid=4686022&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F4%2F296%3Frss%3D1 Behçet’s disease (BD) is a multisystemic disorder characterized by endothelial dysfunction. However, the relationship between oxidative stress and endothelial function has not been clearly shown. We investigated the relationship between oxidative stress markers and endothelial function in patients with BD. Patients with BD (n = 40) having active disease and sex- and age-matched 40 controls were included. Endothelial function was assessed by flow-mediated dilatation (FMD) technique. Serum gamma-glutamyltransferase (GGT) and high-sensitive C-reactive protein levels (hsCRP) were measured in all participants. Brachial artery FMD was significantly lower in patients with BD than in controls. Gamma-glutamyltransferase and hsCRP levels were higher in patients with BD than in controls.... Angiology journals http://www.medworm.com/rss/comments.php?id=4686022 Tue, 05 Apr 2011 23:00:00 +0100 4686022 http://www.medworm.com/index.php?rid=4686021&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F4%2F291%3Frss%3D1 We assessed serum uric acid (SUA) levels in patients with type 2 diabetes mellitus (T2DM) with or without peripheral neuropathy (diagnosed by the Neuropathy Disability score [NDS]). We enrolled 64 patients with T2DM with peripheral neuropathy (group A: 31 men, mean age 63.0 ± 2.8 years) and 66 age-, gender-, renal function- and T2DM duration-matched patients without neuropathy (group B: 32 men, mean age 62.4 ± 3.1 years). Serum uric acid was significantly higher in group A (P < .001). There was a significant correlation between SUA and NDS in both groups (group A: rs = .93, P < .001; group B: r s = .95, P < .001). C-reactive protein (CRP) was also significantly higher in group A (P < .001) and correlated significantly with SUA in both groups (group A: rs = .93, P ... Angiology journals http://www.medworm.com/rss/comments.php?id=4686021 Tue, 05 Apr 2011 23:00:00 +0100 4686021 http://www.medworm.com/index.php?rid=4686020&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F4%2F285%3Frss%3D1 Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age, affecting around 10% of them. Polycystic ovary syndrome is considered to be related to increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). There are 2 definitions for PCOS: one adopted in 1990 (classical PCOS with phenotypes A and B) and the otherin 2003 (Rotterdam criteria with 4 phenotypes A to D). The latter is a wider definition including the 1990 phenotypes. There is mounting data suggesting that phenotypes C and D are not actually related to increased CVD risk, and thus screening for CVD risk factors of intervening for primary CVD prevention in young women is not cost-effective. There is an increasing number of suggestions to return to the 1990 criteria plus some metab... Angiology journals http://www.medworm.com/rss/comments.php?id=4686020 Tue, 05 Apr 2011 23:00:00 +0100 4686020 http://www.medworm.com/index.php?rid=4594089&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F3%2F278%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4594089 Mon, 14 Mar 2011 00:00:00 +0100 4594089 http://www.medworm.com/index.php?rid=4594088&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F3%2F276%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4594088 Mon, 14 Mar 2011 00:00:00 +0100 4594088 http://www.medworm.com/index.php?rid=4594087&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F3%2F270%3Frss%3D1 We compared the dietary intake of participants with peripheral artery disease (PAD) and claudication with diet recommendations of the National Cholesterol Education Program (NCEP) and dietary reference intake values recommended by the Institute of Medicine (IOM) of the National Academy of Sciences. Forty-six participants consumed a mean macronutrient composition of 17% protein, 51% carbohydrate, and 30% fat. Compared to the NCEP and IOM recommendations, few participants met the recommended daily intake for sodium (0%), vitamin E (0%), folate (13%), saturated fat (20%), fiber (26%), and cholesterol (39%). Participants with PAD and claudication have poor nutrition, with diets particularly high in saturated fat, sodium, and cholesterol, and low in fiber, vitamin E, and folate intakes. Partici... Angiology journals http://www.medworm.com/rss/comments.php?id=4594087 Mon, 14 Mar 2011 00:00:00 +0100 4594087 http://www.medworm.com/index.php?rid=4594086&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F3%2F265%3Frss%3D1 Conclusion: Triptolide-coated stent showed the effect of preventing restenosis via inhibition of neointimal hyperplasia and anti-inflammation acts after coronary angioplasty. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4594086 Mon, 14 Mar 2011 00:00:00 +0100 4594086 http://www.medworm.com/index.php?rid=4594085&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F3%2F257%3Frss%3D1 The aim of this study was to determine whether the adoption of new performance processes reduced the door-to-balloon time for primary percutaneous coronary intervention (PCI). To reduce the door-to-balloon time, we adopted 3 new performance processes: concurrent activation at the emergency department rather than stepwise activation; direct phone call rather than using a pager or message; patient transferred to catheterization laboratory before the PCI team arrive. A total of 139 consecutive patients were compared before and after the new performance processes. After the adoption of the new processes, median door-to-balloon time reduced significantly from 133 to 76 minutes (P < .0001) and patients undergoing primary PCI within 90 minutes increased significantly from 16% to 72% (P < .0... Angiology journals http://www.medworm.com/rss/comments.php?id=4594085 Mon, 14 Mar 2011 00:00:00 +0100 4594085 http://www.medworm.com/index.php?rid=4594084&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F3%2F253%3Frss%3D1 Conclusions: Despite varying symptom duration prior to diagnosis, fibrin D-dimer remains a sensitive measure of venous thrombosis and correlates with thrombus volume. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4594084 Mon, 14 Mar 2011 00:00:00 +0100 4594084 http://www.medworm.com/index.php?rid=4594083&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F3%2F248%3Frss%3D1 Superior vena cava (SVC) obstruction occurs in patients with intrathoracic malignancies. Clinical symptoms can be distressing but presentation is insidious. We investigated the outcome of endovascular management for patients with SVC syndrome. We retrospectively reviewed the case histories of 17 patients (9 men) from January 2003 to June 2009. All patients had malignant disease. There were 24 interventions (2 patients with 2 interventions and 2 patients with 3 interventions). All had SVC stenosis over 90%. All patients were treated with intrathoracic angioplasty and stenting. All procedures were technically successful, and all patients had insertion of 10 to 18 mm diameter stents with symptom resolution in 16 patients. There were 2 occlusions at 1 and 6 weeks and 2 patients with restenosis... Angiology journals http://www.medworm.com/rss/comments.php?id=4594083 Mon, 14 Mar 2011 00:00:00 +0100 4594083 http://www.medworm.com/index.php?rid=4594082&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F3%2F245%3Frss%3D1 Impairment of endothelial functions has been shown to occur after acute and chronic exposure to passive smoking (PS), as assessed by flow-mediated dilatation (FMD) of the brachial artery. A total of 61 participants, 30 male and 31 female, mean ages 26 (18-36) were enrolled in the study. All were clinically well and nonsmokers. All participants stayed for 30 minutes in the smoking room. Carbon monoxide (CO) level was 7.42 ± 0.98 ppm (4.71-10.50). Mean carboxyhemoglobin (COHb) levels of participants were significantly elevated after PS. Mean FMD was 18.6% ± 9% and decreased to 12.4% ± 7% after PS (P < .001). In the current study, with more number of participants at lower CO concentrations (7.42 ppm) and with smaller increase in COHb (51%) significant reduction (33%, P... Angiology journals http://www.medworm.com/rss/comments.php?id=4594082 Mon, 14 Mar 2011 00:00:00 +0100 4594082 http://www.medworm.com/index.php?rid=4594081&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F3%2F237%3Frss%3D1 We evaluated the association of blood monocyte and platelet activation markers with the risk of peripheral artery disease (PAD) in a multicenter study of atherosclerosis among African American and Caucasian patients. Flow cytometric analysis of blood cells was performed in 1791 participants (209 cases with PAD and 1582 noncases) from the cross-sectional Atherosclerosis Risk in Communities Carotid Magnetic Resonance Imaging ([MRI] ARIC Carotid MRI) Study to assess platelet glycoproteins IIb and IIIa, P-selectin, CD40 ligand, platelet—leukocyte aggregates, monocyte lipopolysaccharide receptor, toll-like receptors (TLRs) 2 and 4, P-selectin glycoprotein ligand 1, cyclooxygenase 2, and myeloperoxidase. Multivariate regression analyses evaluated the association of cellular markers with th... Angiology journals http://www.medworm.com/rss/comments.php?id=4594081 Mon, 14 Mar 2011 00:00:00 +0100 4594081 http://www.medworm.com/index.php?rid=4594080&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F3%2F231%3Frss%3D1 Population-based studies have demonstrated differences in intima—media thickness (IMT) measured from the left and right common carotid arteries (CCAs). However, its prognostic implications among patients with established coronary artery disease (CAD) remain unknown. Correlations between the left and right CCAs and the composite end point of cardiac death or nonfatal acute coronary syndrome among 149 patients with angiographically confirmed stable CAD were studied. A total of 22 patients had cardiovascular events during the 32.1 ± 10.9 months follow-up. Multivariate analysis revealed that prior ischemic stroke (hazard ratio [HR]: 15.36, 95% confidence interval [CI]: 4.49-52.59, P < .001), extent of CAD (HR: 1.56, 95%CI: 1.01-2.42, P = .046), and right CCA IMT (HR: 17.07, 95%... Angiology journals http://www.medworm.com/rss/comments.php?id=4594080 Mon, 14 Mar 2011 00:00:00 +0100 4594080 http://www.medworm.com/index.php?rid=4594079&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F3%2F225%3Frss%3D1 The nephroprotective role of N-acetylcysteine (NAC) against contrast-induced nephropathy (CIN) in patients undergoing peripheral arterial angiography remains unclear. A total of 40 patients undergoing peripheral arterial angiography were randomized to receive intravenous (iv) hydration only (group 1) or oral NAC in addition to iv hydration (group 2; ISRCTN: 35882618). Primary outcome was reduction in the elevation of urinary retinol binding protein (RBP), albumin—creatinine ratio (ACR), and serum creatinine (serC). Groups 1 and 2 had equivocal percentage reduction in RBP and ACR levels from baseline (P = .80 and .30). A significant reduction in serC was, however, observed with NAC by third postprocedure day (P = .04). One patient in the treatment arm developed CIN compared with 3 pat... Angiology journals http://www.medworm.com/rss/comments.php?id=4594079 Mon, 14 Mar 2011 00:00:00 +0100 4594079 http://www.medworm.com/index.php?rid=4594078&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F3%2F219%3Frss%3D1 End-stage renal disease (ESRD) was universally fatal until dialysis (peritoneal and hemodialysis) and renal transplantation were introduced. However, there are multiple complications associated with transplantation including transplant renal artery stenosis (TRAS). Transplant renal artery stenosis is an important cause of premature renal failure, uncontrolled hypertension, and allograft loss. There are 3 treatment modalities available for TRAS: optimal medical therapy alone, percutaneous intervention, and surgical revascularization both with optimal medical therapy. Percutaneous transluminal angioplasty (PTA) has now become the initial treatment of choice for TRAS. However, there are conflicting data regarding the efficacy of PTA, with growing evidence showing lack of significant benefit i... Angiology journals http://www.medworm.com/rss/comments.php?id=4594078 Mon, 14 Mar 2011 00:00:00 +0100 4594078 http://www.medworm.com/index.php?rid=4594077&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F3%2F209%3Frss%3D1 Platelet activating factor (PAF) is implicated in cardiovascular disease (CVD). Statins are widely used in these situations. Therefore, we assessed their effect on the biological activities and metabolism of PAF. Several statins, including simvastatin, exhibited an inhibitory effect against PAF, comparable with that of PAF-inhibitors. Simvastatin also suppressed in vivo PAF-biosynthesis via the de novo pathway, in leukocytes of 6 simvastatin-treated volunteers. Total cholesterol and low-density lipoprotein cholesterol were also significantly decreased, whereas high-density lipoprotein cholesterol, triacylglycerol, EC50, and lag time were unaffected in these participants. Simvastatin with an intact lactone ring also inhibited PAF-activities, while incubation of human mesangial cells with it... Angiology journals http://www.medworm.com/rss/comments.php?id=4594077 Mon, 14 Mar 2011 00:00:00 +0100 4594077 http://www.medworm.com/index.php?rid=4327269&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F198%3Frss%3D1 Conclusion: Residual-GSV is an important cause for recurrent VV. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4327269 Mon, 10 Jan 2011 00:00:00 +0100 4327269 http://www.medworm.com/index.php?rid=4327268&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F191%3Frss%3D1 Genetic factors contribute to the pathogenesis of coronary artery disease (CAD). We studied 100 patients with CAD and 50 healthy individuals to assess the association of endothelial nitric oxide (eNOS) polymorphism (Glu298Asp) and angiotensinogen polymorphisms (M235T) and CAD in an Egyptian population. Serum nitric oxide (NO) and angiotensin I levels were also measured. The frequency of Glu298Asp and M235T polymorphisms were higher in the CAD group compared with controls. The mean level of NO was significantly lower (P < .05) while angiotensin I was significantly higher (P < .05) in patients CAD than in controls. The frequency of eNOS TT allele of M235T variant was significantly higher in patients with CAD (20% vs 6%). The frequency of angiotensinogen (AGT) TT and T allele in patient... Angiology journals http://www.medworm.com/rss/comments.php?id=4327268 Mon, 10 Jan 2011 00:00:00 +0100 4327268 http://www.medworm.com/index.php?rid=4327267&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F184%3Frss%3D1 We assessed the changes in serum antiheat shock protein (HSP)-27 antibody and high-sensitivity C-reactive protein (hsCRP) levels, following the placement of a drug-eluting stent (DES) or bare-metal stent (BMS) in patients with stable coronary artery disease. Either a BMS or DES was implanted in 137 patients (82 BMS; 55 DES). Anti-HSP27 and hsCRP levels were measured 24 hours before and 24 hours after stenting. Median hsCRP serum levels increased significantly to 60.78 (10.13-84.87) and 77.80 (50.00-84.84) mg/L for BMS and DES groups (P = .006 and P = .000, respectively); this increase did not differ significantly between the 2 groups. Median anti-HSP27 antibody levels decreased to 0.26 (0.17-0.49) and 0.21 (0.16-0.29) absorbency units in BMS and DES groups (P = .045 and P = < 0.001, res... Angiology journals http://www.medworm.com/rss/comments.php?id=4327267 Mon, 10 Jan 2011 00:00:00 +0100 4327267 http://www.medworm.com/index.php?rid=4327266&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F176%3Frss%3D1 Conclusion: Plasma sFlt-1 levels are positively associated with the presence of CAD and are associated with angiographical severity of CAD. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4327266 Mon, 10 Jan 2011 00:00:00 +0100 4327266 http://www.medworm.com/index.php?rid=4327265&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F167%3Frss%3D1 Rheumatoid arthritis (RA) associates with excess cardiovascular risk and there is a need to assess that risk. However, individual lipid levels may be influenced by disease activity and drug use, whereas lipid ratios may be more robust. A cross-sectional cohort of 400 consecutive patients was used to establish factors that influenced individual lipid levels and lipid ratios in RA, using multiple regression models. A further longitudinal cohort of 550 patients with RA was used to confirm these findings, using generalized estimating equations. Cross-sectionally, higher C-reactive protein (CRP) levels correlated with lower levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol ([HDL-C] P ≤ .015), whereas lipid ratios did not c... Angiology journals http://www.medworm.com/rss/comments.php?id=4327265 Mon, 10 Jan 2011 00:00:00 +0100 4327265 http://www.medworm.com/index.php?rid=4327264&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F163%3Frss%3D1 We assessed the effect of glucose and insulin on human monocytes. Monocytes were isolated from 16 healthy obese and 10 lean healthy participants. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. Obese participants were subdivided into 2 subgroups: insulin sensitive (IS) and insulin resistant (IR). Monocyte oxidized low-density lipoprotein (oxLDL) phagocytosis was assessed pre and poststimulation in vitro with glucose or insulin. Experiments were repeated after incubation with a Na+/H+ exchanger-1 inhibitor ([NHE-1]; cariporide) or rosiglitazone. Glucose increased oxLDL phagocytosis in all groups studied (at 1 or 3 hours incubation; P = .037-.002). Insulin increased oxLDL phagocytosis in all groups studied after 1-hour incubation (P = .027-.015) but not at 3 hours. Inc... Angiology journals http://www.medworm.com/rss/comments.php?id=4327264 Mon, 10 Jan 2011 00:00:00 +0100 4327264 http://www.medworm.com/index.php?rid=4327263&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F155%3Frss%3D1 In humans, the pathophysiological inflammation response subsequent to hypoxia and reoxygenation often leads to systemic inflammation and multiorgan failure. We applied a newly developed static interaction model using human polymorphonuclear neutrophils and microvasular endothelial cells to clarify the role of hypoxia and hypoxia/reoxygenation in vitro. Human dermal microvasular endothelial cell cultures (n = 7) were exposed to hypoxia and different reoxygenation periods and the adherence rate of neutrophils to the endothelial cells as well as to the protein matrix on the culture slide surface were determined by quantitative microscopy. Hypoxia clearly triggered neutrophil adhesion to human dermal microvasular endothelial cells whereas additional reoxygenation significantly decreased neutro... Angiology journals http://www.medworm.com/rss/comments.php?id=4327263 Mon, 10 Jan 2011 00:00:00 +0100 4327263 http://www.medworm.com/index.php?rid=4327262&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F144%3Frss%3D1 Conclusions: High-dose atorvastatin treatment resulted in optimization of the lipid profile in the presence of a high-fat atherogenic diet in a mouse model. Our results suggest that high-dose atorvastatin treatment may be the optimal treatment option for the dyslipidemia associated with MetS. Nevertheless, verification of these results in humans is required before any definite conclusions can be drawn. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4327262 Mon, 10 Jan 2011 00:00:00 +0100 4327262 http://www.medworm.com/index.php?rid=4327261&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F140%3Frss%3D1 Conclusion: The present study, showed us a relationship between CCR2-V64I polymorphism and AAA. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4327261 Mon, 10 Jan 2011 00:00:00 +0100 4327261 http://www.medworm.com/index.php?rid=4327260&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F134%3Frss%3D1 The carotid artery intima—media thickness (IMT) is an established surrogate marker of vascular risk. We assessed the common femoral artery IMT and its correlation with coronary artery disease (CAD). We also assessed the influence of vascular risk factors on the femoral IMT. Patients (n = 180; mean age 60.4 ± 10.5 years) who had undergone coronary angiography due to symptoms of CAD were enrolled in this study. We found significantly higher values of femoral IMT in patients with CAD than in those without CAD (P = .0000). A strong positive correlation between femoral IMT and the severity of CAD expressed by the Gensini Score (P = .0000) was observed. There was a positive correlation between femoral IMT and levels of triglycerides (P = .017), body mass index (BMI; P = .036), male ... Angiology journals http://www.medworm.com/rss/comments.php?id=4327260 Mon, 10 Jan 2011 00:00:00 +0100 4327260 http://www.medworm.com/index.php?rid=4327259&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F126%3Frss%3D1 The association between novel atherosclerotic risk biomarkers and severity of peripheral arterial disease (PAD) was assessed. Patients (n = 133) with PAD were recruited. Established risk biomarkers including low- and high-density cholesterol, triglycerides, and blood pressure were measured. Novel risk biomarkers including plasma C-reactive protein, von Willebrand factor (vWF), interleukin 6, red cell folate (RCF), vitamin B12, total homocysteine (tHcy), and Hcy genotypes were also determined. The severity of PAD was evaluated, using ankle—brachial pressure index (ABPI), brachial—knee, and brachial—ankle pulse wave velocity (bk- and ba-PWV). Plasma tHcy and systolic blood pressure had a positive independent correlation with bk-PWV (β = +0.56, P = .02 and β = +0.3... Angiology journals http://www.medworm.com/rss/comments.php?id=4327259 Mon, 10 Jan 2011 00:00:00 +0100 4327259 http://www.medworm.com/index.php?rid=4327258&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F119%3Frss%3D1 In conclusion, CFE can be performed in CLI with high technical success and there is no significant effect of runoff score on recurrence of symptoms. Limb salvage can be achieved even if options to restore inline flow are limited. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4327258 Mon, 10 Jan 2011 00:00:00 +0100 4327258 http://www.medworm.com/index.php?rid=4327257&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F111%3Frss%3D1 We report a prospective 2-year, multicenter study of patients presenting with intermittent claudication (IC; ankle brachial blood pressure index, ABPI ≤ 0.9). Mean age of the 473 patients enrolled was 68 years, 20% were diabetics, 30% had prior symptomatic coronary heart disease (CHD), 7% had prior stroke, and 39% were current smokers. At baseline, 26.2% of patients had BP ≤ 140/85 mm Hg or lower and at 2 years this figure was 32.5% (P = .01). Current smokers had fallen to 27% (from 39%) at 2 years (P < .001). Use of antiplatelet agents, statins, and angiotensin converting enzyme inhibitors increased significantly during the course of the study as did claudication distance. Death and the composite of death, stroke or myocardial infarction (MI), occurred in 8.4% and 11.6% of patien... Angiology journals http://www.medworm.com/rss/comments.php?id=4327257 Mon, 10 Jan 2011 00:00:00 +0100 4327257 http://www.medworm.com/index.php?rid=4327256&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F2%2F107%3Frss%3D1 Serum gamma-glutamyltransferase (GGT) activity is a marker of oxidative stress and activity is associated with cardiovascular disease. Carotid intima-media thickness (IMT) is a noninvasive predictor of atherosclerosis. We investigated the association between serum GGT activity and carotid IMT. Fifty-five persons who had normal liver function tests were consecutively enrolled. Carotid IMT was evaluated in the right and left common carotid arteries. The averaged values of carotid IMT and serum GGT activity were compared. Serum GGT activity correlated with carotid IMT (r = .396, P = .003). Serum GGT activities were increased in patients with carotid intimal hyperplasia compared with those without intimal hyperplasia (20.3 ± 11.2 vs 34.3 ± 16.1 U/L; P = .001). Serum GGT activity ... Angiology journals http://www.medworm.com/rss/comments.php?id=4327256 Mon, 10 Jan 2011 00:00:00 +0100 4327256 http://www.medworm.com/index.php?rid=4327255&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F2%2F105%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4327255 Mon, 10 Jan 2011 00:00:00 +0100 4327255 http://www.medworm.com/index.php?rid=4394979&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F62%3Frss%3D1 The publisher and editor have retracted the article from the issue (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4394979 Mon, 06 Dec 2010 00:00:00 +0100 4394979 http://www.medworm.com/index.php?rid=4230820&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F1%2F100%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4230820 Mon, 06 Dec 2010 00:00:00 +0100 4230820 http://www.medworm.com/index.php?rid=4230819&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F92%3Frss%3D1 This study suggests that medical therapy may exert beneficial effects in patients with RAS. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4230819 Mon, 06 Dec 2010 00:00:00 +0100 4230819 http://www.medworm.com/index.php?rid=4230818&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F87%3Frss%3D1 We examined telomere length (TL) and change in ankle-brachial index (ABI) over 5 years in a Chinese population aged 65 years and older living in the community. Telomere length was determined using the quantitative polymerase chain reaction (PCR) method in 976 men and 1030 women. Ankle-brachial index was measured using Doppler ultrasound. Analysis of covariance was used to examine the relationship between quartiles of TL and baseline ABI values as well as percentage change in ABI, adjusting for confounders. Women had longer TL and lower ABI values compared with men, and there was a significant trend for an inverse association between TL and percentage decline in ABI after adjustment for confounders. No significant association was observed in men. The findings support the association between... Angiology journals http://www.medworm.com/rss/comments.php?id=4230818 Mon, 06 Dec 2010 00:00:00 +0100 4230818 http://www.medworm.com/index.php?rid=4230817&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F81%3Frss%3D1 We examined the effects of walk training with BFR on carotid arterial compliance and muscle size in the elderly adults. Both BFR-walk training (BFR-W, n = 13, 66 ± 1 year) and control-walk training (CON-W, n = 10, 68 ± 1 year) groups performed 20 minutes treadmill walking at an exercise intensity of 45% of heart rate reserve, 4 days/week for 10 weeks. The BFR-W group wore pressure cuffs on both legs during training. Maximum knee joint strength (~15%) and MRI-measured thigh muscle cross-sectional area (3%) increased in the BFR-W, but not in the CON-W. Carotid arterial compliance improved in both BFR-W (50%) and CON-W (59%) groups. Walk training with blood flow reduction can improve thigh muscle size/strength as well as carotid arterial compliance, unlike high-intensity trainin... Angiology journals http://www.medworm.com/rss/comments.php?id=4230817 Mon, 06 Dec 2010 00:00:00 +0100 4230817 http://www.medworm.com/index.php?rid=4230816&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F74%3Frss%3D1 We evaluated the relationship between coronary artery stenosis status and established cardiovascular risk factors in a large population of 1228 patients who consecutively underwent coronary angiography. Smoking proved to be the most important predictive factor for angiographically significant coronary artery disease (CAD), followed by dyslipidemia, diabetes, family history, and hypertension in a descending order of significance. Obesity rates did not differ significantly between the CAD positive and negative groups, nor changed significantly as the number of affected vessels increased. Smoking, dyslipidemia, and diabetes were positively associated with atherosclerotic involvement of all 3 major coronary arteries, whereas hypertension related only to significant stenosis of left anterior de... Angiology journals http://www.medworm.com/rss/comments.php?id=4230816 Mon, 06 Dec 2010 00:00:00 +0100 4230816 http://www.medworm.com/index.php?rid=4230815&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F68%3Frss%3D1 The use of coronary artery bypass grafting (CABG) in primary treatment of acute myocardial infarction is still debated. We evaluated the predictors of mortality in patients undergoing primary CABG for ST-elevated myocardial infarction (STEMI). Between January 2003 and January 2008, all patients referred to our institution with STEMI who did not qualify for primary angioplasty and required CABG were included in this study. Survivors and nonsurvivors were compared retrospectively in terms of demo-graphics, preoperative, intraoperative, and postoperative characteristics. Preoperatively confirmed cases of STEMI (n = 150) were included in the analysis. There were 114 survivors and 36 nonsurvivors. In-hospital mortality rate was 22%. In Cox regression analysis age, cardiogenic shock (Killip ≥... Angiology journals http://www.medworm.com/rss/comments.php?id=4230815 Mon, 06 Dec 2010 00:00:00 +0100 4230815 http://www.medworm.com/index.php?rid=4230814&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F62%3Frss%3D1 This study suggests that periodontitis is a potential modifiable risk factor for CVD. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4230814 Mon, 06 Dec 2010 00:00:00 +0100 4230814 http://www.medworm.com/index.php?rid=4230813&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F55%3Frss%3D1 We examined prospectively 60 consecutive patients with DCM. Of them, 30 were dyslipidemic (group I) and 30 normolipidemic (group II). Group I patients were randomized to either simvastatin therapy (20 mg/day, group Ia, n = 15) or hypolipidemic diet therapy (group Ib, n = 15). Patients were re-evaluated 6 months later. High-sensitivity C-reactive protein and sIL-2R levels were significantly higher in group I compared with group II patients (19.5 ± 3.4 vs 3.03 ± 3.5 mg/L, P = .01, 1137 ± 441 vs 599 ± 235 pg/mL, P = .001, respectively). There was a significant correlation between sIL-2R and hsCRP levels in dyslipidemic patients but not in normolipidemic patients. Significant reduction of hsCRP and sIL-2R levels was observed only in group Ia patients. Patients with ... Angiology journals http://www.medworm.com/rss/comments.php?id=4230813 Mon, 06 Dec 2010 00:00:00 +0100 4230813 http://www.medworm.com/index.php?rid=4230812&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F49%3Frss%3D1 Conclusion: Great saphenous vein occlusion was achieved efficiently in 94% of our group using RFA with minimal complications and obvious advantages as compared to standard surgery. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4230812 Mon, 06 Dec 2010 00:00:00 +0100 4230812 http://www.medworm.com/index.php?rid=4230811&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F46%3Frss%3D1 Conclusion: Percutaneous transluminal angioplasty and Gianturco stent placement is a safe and effective treatment for IVC outflow compromise in the early postoperative period following orthotopic liver transplantation. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4230811 Mon, 06 Dec 2010 00:00:00 +0100 4230811 http://www.medworm.com/index.php?rid=4230810&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F38%3Frss%3D1 We assessed the effect of epinephrine on human monocytes. Monocytes were isolated from 16 healthy obese and 10 lean healthy subjects. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. Obese subjects were subdivided into 2 sub-groups, insulin sensitive (IS) and insulin resistant (IR). Monocyte properties [attachment to laminin 1, migration through laminin 1, oxidized-low density lipoprotein (oxLDL) phagocytosis] were assessed pre- and post-stimulation in vitro with epinephrine. Experiments were repeated after incubation with a Na+/H + exchanger-1 inhibitor (NHE-1) (cariporide). Epinephrine increased monocyte attachment to laminin in lean and obese IR subjects through involvement of NHE-1, PKC, NO synthase, NADPH oxidase and actin polymerization. In contrast, epinephrine... Angiology journals http://www.medworm.com/rss/comments.php?id=4230810 Mon, 06 Dec 2010 00:00:00 +0100 4230810 http://www.medworm.com/index.php?rid=4230809&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F33%3Frss%3D1 The effects of acute exercise on arterial compliance in older adults are unknown. Large and small arterial compliance were assessed during and 24 hours following a 30-minute bicycle ergometer test and on a nonexercise, control condition. The change in large artery compliance was similar between the exercise and nonexercise conditions (P = 0.876). Small artery compliance during the exercise day was higher than the nonexercise day at 45, 60, and 75 minutes following exercise (P < .001), was 17% higher 30 minutes postexercise than at rest (P < .001), and decreased by 20% between 30 minutes (4.5 ± 0.4 mL/mm Hg x 100) and 120 minutes (3.6 ± 0.3 mL/mm Hg x 100) after exercise (P = .027). The current study shows 30 minutes of moderate-intensity exercise transiently increases s... Angiology journals http://www.medworm.com/rss/comments.php?id=4230809 Mon, 06 Dec 2010 00:00:00 +0100 4230809 http://www.medworm.com/index.php?rid=4230808&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F18%3Frss%3D1 Conclusion: The genetic basis of AAA remains unknown, and most results from ‘‘candidate-gene’’ association studies are contradictory. Further analyses in appropriately powered studies in large, phenotypically well-characterized populations, including genome-wide association studies, are necessary to elucidate the exact genetic contribution to the pathophysiology of AAA. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4230808 Mon, 06 Dec 2010 00:00:00 +0100 4230808 http://www.medworm.com/index.php?rid=4230807&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F15%3Frss%3D1 Skin perfusion pressure (SPP) is a measure of peripheral circulation; low SPP (<40 mm Hg) indicates poor wound healing. Cilostazol is used to alleviate symptoms and improve walking distance in patients with peripheral artery disease (PAD), but its effect on SPP is unknown. We enrolled patients whose symptoms were Rutherford class 3 or 4 and whose SPP was <40 mm Hg. We analyzed patient symptoms, ankle-brachial index (ABI), and SPP before and 1 month after treatment with cilostazol. We analyzed 20 legs of 14 patients. Cilostazol improved symptoms in 12 legs. The average heart rate increased from 76 ± 16 to 84 ± 20 beats/min (P < .05). Cilostazol did not increase the ABI but caused a significant increase in the SPP from 24.5 ± 8.88 to 42.8 ± 21.0 mm Hg (P ... Angiology journals http://www.medworm.com/rss/comments.php?id=4230807 Mon, 06 Dec 2010 00:00:00 +0100 4230807 http://www.medworm.com/index.php?rid=4230806&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F62%2F1%2F10%3Frss%3D1 Peripheral arterial disease (PAD) is a marker of atherosclerosis, which is not well studied in the population with human immunodeficiency virus (HIV). We prospectively enrolled HIV-infected patients who had normal resting ankle-brachial index (rABI) readings. All participants performed either a treadmill walking test (TT) or pedal plantar flexion test (PFT). Patients were divided into 2 groups according to postexercise changes; PAD and No-PAD group. The 2 groups were compared with regard to established cardiovascular disease risk factors and other HIV infection parameters. Peripheral arterial disease was present in 30 (26.5%) of 113 consecutive HIV-infected patients included in the study. Mean age was 47 ± 10 years. The risk factors studied did not differ significantly among the 2 g... Angiology journals http://www.medworm.com/rss/comments.php?id=4230806 Mon, 06 Dec 2010 00:00:00 +0100 4230806 http://www.medworm.com/index.php?rid=4230805&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F1%2F7%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4230805 Mon, 06 Dec 2010 00:00:00 +0100 4230805 http://www.medworm.com/index.php?rid=4230804&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Freprint%2F62%2F1%2F5%3Frss%3D1 (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4230804 Mon, 06 Dec 2010 00:00:00 +0100 4230804 http://www.medworm.com/index.php?rid=4068174&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F807%3Frss%3D1 A 51-year old Middle-Eastern man presented with recurrent chest pain associated with ST-segment elevation. The patient was treated with placement of a stent in the right coronary artery. He was subsequently diagnosed with severe hyperthyroidism secondary to Graves disease, which is thought to be the cause of the coronary spasm. The patient was treated with neomercazole and potassium iodide solution, and diltiazem, and nitrates with resolution of his symptoms. This unusual case highlights the importance of considering hyperthyroidism in the differential diagnosis of recurrent chest pain and coronary artery spasm. We suggest routine thyroid function testing in patients with coronary spasm. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4068174 Wed, 13 Oct 2010 23:00:00 +0100 4068174 http://www.medworm.com/index.php?rid=4068173&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F802%3Frss%3D1 Portopulmonary hypertension (PPHTN) is a rare complication in patients with portal hypertension. A role of endothelin 1 (ET-1) and other cytokines was demonstrated in primary pulmonary hypertension but not in PPHTN. We evaluated the possible role of ET-1, interleukin 6 (IL-6), interleukin 1β (IL-1β), and tumor necrosis factor alpha (TNF-) in the pathogenesis of PPHTN. Plasmatic concentrations of ET-1, IL-6, IL-1β, and TNF- were measured in patients with pulmonary systolic arterial pressure (PAPs) >30 mm Hg and in patients with cirrhosis. In all, Six out of 11 patients with PAPs >30 mm Hg had PPHTN on right heart catheterization. The remaining 10 patients had an hyperdynamic circulation (HC). In PPHTN patients, ET-1 and IL-6 were significantly higher compared with HC an... Angiology journals http://www.medworm.com/rss/comments.php?id=4068173 Wed, 13 Oct 2010 23:00:00 +0100 4068173 http://www.medworm.com/index.php?rid=4068172&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F793%3Frss%3D1 We examined whether high-sensitivity C-reactive protein (hsCRP) ≥2.0 mg/L was associated with increased intima-media thickness (IMT), plaque burden, and plaque echolucency in carotid arteries. Women (n = 635) from a population sample of 64-year-old females with varying degrees of glucose tolerance underwent risk factor assessment, measurement of hsCRP, and ultrasound examinations of the carotid arteries. Participants with hsCRP levels ≥2.0 mg/L had elevated carotid bulb IMT independently of other cardiovascular risk factors compared with those with hsCRP <2.0 mg/L. The participants with plaques in the highhsCRP group had larger total plaque area compared to those with plaque in the lower hsCRP group. Plaque echolucency did not differ between groups. High-sensitivity CRP levels &ge... Angiology journals http://www.medworm.com/rss/comments.php?id=4068172 Wed, 13 Oct 2010 23:00:00 +0100 4068172 http://www.medworm.com/index.php?rid=4068171&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F789%3Frss%3D1 We looked for risk factors for significant carotid stenosis (CS) in patients with ischemic stroke. We included all patients treated for an ischemic stroke/transient ischemic attack (TIA) and had a carotid duplex done from August 2006 to November 2008. A total of 458 patients were included. Significant CS of the extracranial internal carotid artery and the common carotid artery were found in 10.9% (50 of 458 patients). Age (≥65 years old) was the independent risk factor for CS (OR 4.0, P < .0001). The patients with a CS had more history of coronary artery disease (12% vs 8%, P = .32), prior ischemic stroke (18% vs 11%, P = .17), atrial fibrillation (10% vs 5%, P = .19), and smoking (28% vs 24%, P = .18) compared with the patients without CS. The evaluation of the carotid arteries shou... Angiology journals http://www.medworm.com/rss/comments.php?id=4068171 Wed, 13 Oct 2010 23:00:00 +0100 4068171 http://www.medworm.com/index.php?rid=4068170&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F784%3Frss%3D1 The metabolic syndrome (MetS) is associated with increased cardiovascular morbidity and mortality. Intermittent claudication reflects the presence of peripheral arterial disease (PAD). The aim of this study is to determine the prevalence of the MetS in claudicants and its correlation with age, gender, localization of arterial obstruction, and symptomatic coronary disease. Patients (n = 170) with intermittent claudication were studied. The mean age was 65 years (33-89). Metabolic syndrome was diagnosed in 98 patients (57.6%). The mean age of patients with MetS was 63.5 years compared with 67.0 years for patients without MetS (P = .027). Considering patients aged ≥65 years, MetS was present in 46 (48.9%) individuals and in 52 (68.4%) patients younger than 65 years (P = .011). Metabolic sy... Angiology journals http://www.medworm.com/rss/comments.php?id=4068170 Wed, 13 Oct 2010 23:00:00 +0100 4068170 http://www.medworm.com/index.php?rid=4068169&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F780%3Frss%3D1 In conclusion, this study emphasizes the importance of measuring the ABI in both the posterior tibial and the anterior tibial arteries when diagnosing PAD. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4068169 Wed, 13 Oct 2010 23:00:00 +0100 4068169 http://www.medworm.com/index.php?rid=4068168&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F775%3Frss%3D1 Low-density lipoprotein is recognized as a primary vascular risk factor. However, recent data favor apolipoprotein (apo)B and apoA-I as risk factors with higher predictive values than conventional lipids. We investigated how leisure-time physical activity relates to the serum apoB/apoA-I ratio in middle-aged men. The results showed that compared with a sedentary lifestyle, moderate physical activity was associated with a decreased apoB/apoA-I ratio (1.01 ± 0.28 vs 0.87 ± 0.24, P < .05) and increased apoA-I levels (1.30 ± 0.20 g/L vs 1.43 ± 0.22 g/L, P < .05), whereas vigorous activity was required to observe a reduction in apoB levels (1.27 ± 0.28 g/L vs 1.14 ± 0.24 g/L, P < .05). A covariate analysis showed that leisure time physical acti... Angiology journals http://www.medworm.com/rss/comments.php?id=4068168 Wed, 13 Oct 2010 23:00:00 +0100 4068168 http://www.medworm.com/index.php?rid=4068167&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F768%3Frss%3D1 We assessed the effect of leptin on human monocytes. Monocytes were isolated from 16 healthy obese and 10 lean healthy participants. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. Obese participants were subdivided into 2 subgroups, insulin sensitive (IS) and insulin resistant (IR). Monocyte properties (attachment to laminin 1, migration through laminin 1, surface expression of CD36, oxidized low-density lipoprotein [oxLDL] phagocytosis) were assessed pre- and poststimulation in vitro with leptin. Experiments were repeated after incubation with rosiglitazone and a Na+/H+ exchanger-1 inhibitor (cariporide). We found a significant correlation between insulin resistance and monocyte attachment to laminin and oxLDL phagocytosis. Leptin increased the atherosclerosis-rela... Angiology journals http://www.medworm.com/rss/comments.php?id=4068167 Wed, 13 Oct 2010 23:00:00 +0100 4068167 http://www.medworm.com/index.php?rid=4068166&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F763%3Frss%3D1 Conclusion: This survey demonstrates that HR is poorly controlled in a broadly representative cohort of outpatients with CAD, even in those on β-blocker therapy, mainly because of undertitration of therapy—almost half of the patients with CAD and elevated resting HR are not on β-blockers. This might be related to absolute or relative controindications and to haemodynamic and chronotropic intolerance to beta-blockers. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4068166 Wed, 13 Oct 2010 23:00:00 +0100 4068166 http://www.medworm.com/index.php?rid=4068165&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F756%3Frss%3D1 Conclusion: There is an association between raised serum OPG and reduced s-TRAIL in patients with CAD. Elevation of circulating OPG levels may represent a crucial compensatory mechanism to limit further vascular damage. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4068165 Wed, 13 Oct 2010 23:00:00 +0100 4068165 http://www.medworm.com/index.php?rid=4068164&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F751%3Frss%3D1 Consecutive patients (n = 235) with coronary ischemia were studied; 69 patients (29%) had diabetes. An oral glucose tolerance test (OGTT) was administered to the 166 patients without diabetes; 76 (46%) had normal glucose tolerance (group I = NGT), 68 (41%) had impaired glucose tolerance ([IGT] group II = IGT), and 22 (13%) had diabetic glucose tolerance (DGT). The DGT patients were added to the known diabetics forming (Group III; n = 91). Multivessel disease was significantly more prevalent in group III; 30 patients (43%) in group I, 32 patients (51%) in group II, and 57 patients (69%) in group III (P = .002). Gensini scores were 43.20 ± 24.92 in group I, 54.22 ± 42.61 in group II, and 60.59 ± 38.21 in group III. (P = .037) The severity of coronary artery disease is re... Angiology journals http://www.medworm.com/rss/comments.php?id=4068164 Wed, 13 Oct 2010 23:00:00 +0100 4068164 http://www.medworm.com/index.php?rid=4068163&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F744%3Frss%3D1 We assessed the use and determinants of cardiac catheterization during index admissions, among patients with acute coronary syndrome (ACS) in the Middle East. Data were analyzed from 8150 consecutive ACS patients enrolled prospectively. The overall rate of cardiac catheterization was 20%. Major predictors of cardiac catheterization were university hospitals, hospitals with catheterization facilities, physician type, and Gulf citizenship. High-risk patients were catheterized less compared to low-risk patients; odds ratio (OR) 0.44, 95% confidence interval (CI): 0.33-0.60, P < .001 and OR 0.68, 95% CI: 0.48-0.98, P = .037 for patients with non-ST-elevation ACS and ST-elevation myocardial infarction, respectively. The use of cardiac catheterization in patients with ACS from Middle East is ... Angiology journals http://www.medworm.com/rss/comments.php?id=4068163 Wed, 13 Oct 2010 23:00:00 +0100 4068163 http://www.medworm.com/index.php?rid=4068162&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F737%3Frss%3D1 We assessed the association between (CA)n repeat polymorphism of angiotensinogen (AGT), 250 base pair (bp) insertion/deletion (I/D) of angiotensin-converting enzyme (ACE), tetranucleotide repeat polymorphism (TCTG)n of renin (REN), (CT)n repeat polymorphism of the natriuretic peptide receptor A (NPRA) genes, and the presence and extent of coronary artery disease (CAD) in Greek patients with a history of myocardial infarction (MI). A total of 158 post-MI patients referred for coronary angiography were compared with 144 controls. The SS genotype of the AGT gene was related with an increased risk for 3-vessel CAD (odds ratio [OR], 1.94; 95% confidence interval [CI], 1.05-3.61; P = .041), whereas the SL genotype was related with a decreased risk (OR, 0.44; 95% CI, 0.22-0.87; P = .019). Moreove... Angiology journals http://www.medworm.com/rss/comments.php?id=4068162 Wed, 13 Oct 2010 23:00:00 +0100 4068162 http://www.medworm.com/index.php?rid=4068161&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F731%3Frss%3D1 Conclusion: Serum NGAL and cystatin C could be valuable in the detection of early renal impairment after coronary angiography. (Source: Angiology) Angiology journals http://www.medworm.com/rss/comments.php?id=4068161 Wed, 13 Oct 2010 23:00:00 +0100 4068161 http://www.medworm.com/index.php?rid=4068160&cid=s_29152_7_f&fid=29152&url=http%3A%2F%2Fang.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F61%2F8%2F724%3Frss%3D1 We assessed the usefulness of serum cystatin C for predicting contrast-induced nephropathy (CIN) in patients (n = 100) undergoing coronary catheterization. After a 12-month follow-up, the incidence of CIN was 8.3% (n = 5) in patients with mild renal insufficiency (estimated glomerular filtration rate [eGFR] 60-89 mL/min per 1.73 m2), 34.4% (n = 10) in those with moderate renal insufficiency (eGFR 30-59 mL/min per 1.73 m2), and 100% (n = 3) in those with severe renal insufficiency (eGFR 15-29 mL/min per 1.73 m2). The sensitivity was 81.8% and specificity was 90.9% at the cutoff level of serum cystatin C >1.18 mg/L. Serum cystatin C levels were significantly (P < .001) higher in the patients with moderate renal insufficiency in the CIN group than those in the non-CIN group. Multivariat... Angiology journals http://www.medworm.com/rss/comments.php?id=4068160 Wed, 13 Oct 2010 23:00:00 +0100 4068160