Annals of Hematology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Annals of Hematology' source. Wed, 17 Mar 2010 14:33:20 +0100 Consensus guidelines for the optimal management of adverse events in newly diagnosed, transplant-ineligible patients receiving melphalan and prednisone in combination with thalidomide (MPT) for the treatment of multiple myeloma http://www.medworm.com/index.php?rid=3371742&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F87100n1gr305243m%2F Abstract  Thalidomide has received approval from the European Agency for the Evaluation of Medicinal Products for the treatment of newly diagnosed multiple myeloma (MM) patients older than 65 years or ineligible for transplant. The results of five phase III trials assessing thalidomide in combination with melphalan and prednisone (MPT) have demonstrated significantly improved response rates compared with melphalan and prednisone (MP) alone. Additionally, two of these studies showed that survival was extended by approximately 18 months in patients treated with MPT compared with MP alone. Thalidomide, in combination with MP, is associated with adverse events (AEs) including peripheral neuropathy and venous thromboembolism. In order to optimize the efficacy of MPT, a... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3371742 Mon, 15 Mar 2010 17:54:34 +0100 3371742 Response to lenalidomide in patients with myelodysplastic syndrome with deletion 5q: clinical and cytogenetic analysis of a single centre series http://www.medworm.com/index.php?rid=3371743&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy566587n776n1772%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0932-2Authors Rita Coutinho, University of Barcelona Institute of Hematology and Oncology, Department of Hematology, Hospital Clinic IDIBAPS Villarroel 170 08036 Barcelona SpainDolors Costa, University of Barcelona Hematopathology Unit, Hospital Clinic IDIBAPS Barcelona SpainAna Carrió, University of Barcelona Hematopathology Unit, Hospital Clinic IDIBAPS Barcelona SpainConcha Muñoz, University of Barcelona Hematopathology Unit, Hospital Clinic IDIBAPS Barcelona SpainAna Vidal, University of Barcelona Hematopathology Unit, Hospital Clinic IDIBAPS Barcelona SpainMohammed Belkaid, University of Barcelona Institute of Hematology and Oncology, Department of Hematology, Hospital Clinic IDIBAPS Villarroel 170 0... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3371743 Mon, 15 Mar 2010 17:54:33 +0100 3371743 Combining two orally active iron chelators for thalassemia http://www.medworm.com/index.php?rid=3360859&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc177745t6j34l3j4%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0933-1Authors Vasilios Berdoukas, The Children’s Hospital of Los Angeles The Division of Hematology/Oncology 4650 Sunset Blvd Los Angeles CA 90027-6016 USASusan Carson, The Children’s Hospital of Los Angeles The Division of Hematology/Oncology 4650 Sunset Blvd Los Angeles CA 90027-6016 USAAnne Nord, The Children’s Hospital of Los Angeles The Division of Hematology/Oncology 4650 Sunset Blvd Los Angeles CA 90027-6016 USAAni Dongelyan, The Children’s Hospital of Los Angeles The Division of Hematology/Oncology 4650 Sunset Blvd Los Angeles CA 90027-6016 USAStephen Gavin, The Children’s Hospital of Los Angeles The Division of Hematology/Oncology 4650 Sunset Blvd Los Angeles CA 90027-6016 USAThomas C. Ho... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3360859 Thu, 11 Mar 2010 02:38:47 +0100 3360859 Wnt and Notch signaling pathways selectively regulating hematopoiesis http://www.medworm.com/index.php?rid=3360861&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F30w5061655l02554%2F Abstract  Hematopoietic stem and progenitor cells (HSPCs) are the source of all blood cells in the adult body. The pool of HSPCs is formed during embryogenesis process through a well-characterized succession of intra-embryonic regions and organs. The spatial and temporal restrictions in definitive hematopoietic development and the signaling molecules involved are of great interest as these may prove useful for generating and expanding these clinically important cell populations ex vivo. To elucidate the mechanism by which definitive HSPCs expand during this limited developmental time frame, we analyzed the spatial and temporal programmed gene expression patterns of Wnt and Notch signaling members during hematopoietic development. Genes related to the Wnt signaling pathway w... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3360861 Thu, 11 Mar 2010 02:38:46 +0100 3360861 MYH9-related disease: Report on five German families and description of a novel mutation http://www.medworm.com/index.php?rid=3360860&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbl057l8x4244353x%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0928-yAuthors Anna Savoia, University of Trieste Medical Genetics, Department of Reproductive and Developmental Sciences, Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste ItalyManuela Germeshausen, Hannover Medical School Department of Pediatric Hematology and Oncology Hannover GermanyDaniela De Rocco, University of Trieste Medical Genetics, Department of Reproductive and Developmental Sciences, Institute for Maternal and Child Health, IRCCS “Burlo Garofolo” Trieste ItalyBettina Henschel, Marienhospital Gelsenkirchen Gelsenkirchen GermanyChristian P. Kratz, University of Freiburg Department of Pediatrics and Adolescent Medicine Freiburg GermanyMichaela Kuhlen, Center for Child... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3360860 Thu, 11 Mar 2010 02:38:46 +0100 3360860 Concomitant statin use does not impair the clinical outcome of patients with diffuse large B cell lymphoma treated with rituximab-CHOP http://www.medworm.com/index.php?rid=3356148&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc8302372421wk0w7%2F Abstract  Preclinical data indicated a detrimental effect of statins on the anti-lymphoma activity of rituximab. We evaluated the impact of concomitant statin medication on the response and survival of patients with diffuse large B cell lymphoma (DLBCL) receiving rituximab–cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) as first-line therapy. Medical histories of patients with DLBCL who were treated with R-CHOP as first-line therapy were assessed for concomitant statin use, response after completion of chemotherapy, event-free survival (EFS), and overall survival (OS). Furthermore, 2-[18F]fluor-2-deoxyglucose (FDG)-PET/CT results after completion of first-line therapy were compared between the groups. Overall, 145 patients with DLBCL treated with R-CHOP fro... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3356148 Wed, 10 Mar 2010 15:33:39 +0100 3356148 Does cytogenetic evolution have any prognostic relevance in myelodysplastic syndromes? A study on 153 patients from a single institution http://www.medworm.com/index.php?rid=3356147&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl68x715r97764r44%2F Abstract  The present study was designed to establish the incidence of cytogenetic evolution (CE), defined as the acquisition of chromosomal defects during the course of MDS, in order to correlate it with the WHO classification and IPSS score, and to assess its impact on overall survival (OS) and risk of MDS/AML evolution (progression-free interval, PFI) by means of Cox models for time-dependent covariates. Adjustments for known risk factors were achieved by performing a bivariable analysis. The study was carried out in 153 MDS patients who were followed for a median period of 45.2 months. Disease progression occurred in 42.4% of patients after a 65.2-month median PFI, while CE occurred in 30.7% of patients. Our study shows that (1) CE was more common in advanced than ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3356147 Wed, 10 Mar 2010 15:33:39 +0100 3356147 Gastric mucosa-associated lymphoid tissue lymphoma complicated with hemophagocytic syndrome in an elderly woman http://www.medworm.com/index.php?rid=3328713&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft1752l8600x72710%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0929-xAuthors Hitoshi Ohno, Takeda General Hospital Department of Hematology 28-1, Mori-minami-cho, Ishida, Fushimi-ku Kyoto 601-1495 JapanKengo Takimoto, Takeda General Hospital Department of Gastroenterology Kyoto Japan Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3328713 Tue, 02 Mar 2010 10:00:21 +0100 3328713 Mutations of the TET2 and CBL genes: novel molecular markers in myeloid malignancies http://www.medworm.com/index.php?rid=3328712&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F365956137r144653%2F Abstract  Despite recent progress in molecular research in myeloid malignancies, in subsets of patients with myelodysplastic syndrome (MDS) so far no underlying mutation was identified. In the myeloproliferative neoplasms (MPNs), the JAK2V617F alone cannot explain the phenotypic heterogeneity. In acute myeloid leukemia (AML), clinical variability exists within distinct subgroups. Thus, the search for novel molecular markers continues. Recently, mutations of the tet oncogene family member 2 (TET2) and Casitas B-cell lymphoma (CBL) genes became the focus of interest. With diverse genetic methods, TET2 on chromosome 4q24 was identified as candidate tumor suppressor gene. Sequencing studies revealed heterogeneous mutations in 10–25% of patients with acute myeloid leukemia (AML)... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3328712 Tue, 02 Mar 2010 10:00:21 +0100 3328712 Essential thrombocythemia as underlying cause of malabsorption syndrome http://www.medworm.com/index.php?rid=3313072&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr6049hj127871113%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0924-2Authors Luciana Teofili, Catholic University Department of Hematology Rome ItalyLorenza Torti, Catholic University Department of Hematology Rome ItalyAlessandro Cina, Catholic University Department of Radiology Rome ItalyAntonio Gasbarrini, Catholic University Department of Internal Medicine Rome ItalyMarialuisa Novi, Catholic University Department of Internal Medicine Rome ItalyGiuseppe Leone, Catholic University Department of Hematology Rome ItalyLuigi Maria Larocca, Catholic University Department of Pathology Rome Italy Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3313072 Thu, 25 Feb 2010 06:49:31 +0100 3313072 Mechanisms of platelet recovery in ITP associated with therapy http://www.medworm.com/index.php?rid=3308686&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F155m16q3445n7077%2F Abstract  Immune thrombocytopenia (ITP) is an autoimmune disease primarily characterized by increased clearance of auto-antibody-sensitized platelets by Fc-receptor-bearing macrophages in the spleen and liver. It has been classically accepted that antibody-mediated platelet destruction is Fc dependent. Recent studies, however, may also indicate the involvement of Fc-independent pathways of platelet destruction. Current treatment options work by immunosuppression (e.g., corticosteroids), immunomodulation (e.g., IVIg and anti-D), or removal of the platelet destruction site (splenectomy) in ITP. This review will discuss the mechanisms of action of these and other treatments for ITP. Content Type Journal ArticleCategory Basic ScienceDOI 10.1007/s00277-010-0916-2Authors So... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3308686 Wed, 24 Feb 2010 06:47:48 +0100 3308686 Mean corpuscular volume predicts prognosis in MDS patients with abnormal karyotypes http://www.medworm.com/index.php?rid=3308687&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F87138km2x72g0643%2F In this study, we evaluated the prognostic value of International Prognostic Scoring System (IPSS) and World Health Organization classification-based prognostic scoring system (WPSS) in 164 adult MDS patients with abnormal karyotypes. We also analyzed the prognostic relevance of mean corpuscular volume (MCV) in these patients. We found that both IPSS and WPSS had strong prognostic value in patients with abnormal karyotypes (P < 0.001, P < 0.001). Furthermore, we observed the significant differences in the survival of patients with abnormal karyotypes based on MCV stratification: The median survival of patients with macrocytosis was 31.0 months, significantly longer than the 16.5-month median survival time of patients with MCVs of less than 100 fl (P = 0.00... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3308687 Wed, 24 Feb 2010 06:47:47 +0100 3308687 Hematologic malignancy as a risk factor for bacteremic skin and soft tissue infection caused by gram-negative bacilli http://www.medworm.com/index.php?rid=3308689&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F72287h3136j012v1%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0914-4Authors Cheol-In Kang, Sungkyunkwan University School of Medicine Division of Infectious Diseases, Samsung Medical Center 50 Irwon-dong, Gangnam-gu Seoul 135-710 Republic of KoreaDoo Ryeon Chung, Sungkyunkwan University School of Medicine Division of Infectious Diseases, Samsung Medical Center 50 Irwon-dong, Gangnam-gu Seoul 135-710 Republic of KoreaKyong Ran Peck, Sungkyunkwan University School of Medicine Division of Infectious Diseases, Samsung Medical Center 50 Irwon-dong, Gangnam-gu Seoul 135-710 Republic of KoreaJae-Hoon Song, Sungkyunkwan University School of Medicine Division of Infectious Diseases, Samsung Medical Center 50 Irwon-dong, Gangnam-gu Seoul 135-710 Republic of KoreaKorean Network ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3308689 Wed, 24 Feb 2010 06:47:46 +0100 3308689 Phase IV study evaluating efficacy of escalated dose of imatinib in chronic myeloid leukemia patients showing suboptimal response to standard dose imatinib http://www.medworm.com/index.php?rid=3308688&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp1624724025u6473%2F In conclusion, escalated dose imatinib shows considerable efficacy with tolerable toxicity in CML patients showing suboptimal response to standard dose imatinib. EMR is an early predictive marker for positive imatinib response. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-010-0910-8Authors Youngil Koh, Seoul National University Hospital Department of Internal Medicine 28 Yongon-dong, Jongno-gu Seoul 110-744 Republic of KoreaInho Kim, Seoul National University Hospital Department of Internal Medicine 28 Yongon-dong, Jongno-gu Seoul 110-744 Republic of KoreaSung-Soo Yoon, Seoul National University Hospital Department of Internal Medicine 28 Yongon-dong, Jongno-gu Seoul 110-744 Republic of KoreaByoung Kook Kim, Seoul National University Hospital Department ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3308688 Wed, 24 Feb 2010 06:47:46 +0100 3308688 The role of Fcγ receptors in murine autoimmune thrombocytopenia http://www.medworm.com/index.php?rid=3308690&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6g54380450767358%2F Abstract  Immune thrombocytopenia (ITP) can become a life-threatening condition that requires immediate medical attention. The loss in platelet numbers during ITP can be induced by a variety of triggers. Anti-platelet antibodies of several isotypes and subclasses are a major cause for ITP and are a hallmark of many complex autoimmune diseases such as systemic lupus erythematosus. Mouse models have been important to understand the effector pathways involved in antibody-mediated platelet depletion. Therapeutic interventions based on these results have been proven successful in treating human ITP, thus validating the use of these model systems. One major problem that remains to be answered is which cell populations are crucial for platelet removal. Targeting these cells direct... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3308690 Wed, 24 Feb 2010 06:47:45 +0100 3308690 Acute lymphoblastic leukemia masquerading as juvenile rheumatoid arthritis: no association with survival http://www.medworm.com/index.php?rid=3304251&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb72nq10609p28gwk%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0922-4Authors Matthew J. Murray, Department of Paediatric Haematology and Oncology, Addenbrooke’s Hospital Cambridge CB2 0QQ UKMichael Gattens, Department of Paediatric Haematology and Oncology, Addenbrooke’s Hospital Cambridge CB2 0QQ UKJames C. Nicholson, Department of Paediatric Haematology and Oncology, Addenbrooke’s Hospital Cambridge CB2 0QQ UK Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3304251 Tue, 23 Feb 2010 07:19:00 +0100 3304251 Comparative analysis of outcomes of allogeneic peripheral blood stem cell transplantation from related and unrelated donors http://www.medworm.com/index.php?rid=3304253&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Far218280721g3h4v%2F In conclusion, the survival and relapse incidence were not significantly different between the related and unrelated PBSCT. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-010-0913-5Authors Byung Woog Kang, Kyungpook National University Hospital, Kyungpook National University School of Medicine Department of Hematology/Oncology 200 Dongduk-Ro, Jung-Gu Daegu 700-712 South KoreaJoon Ho Moon, Kyungpook National University Hospital, Kyungpook National University School of Medicine Department of Hematology/Oncology 200 Dongduk-Ro, Jung-Gu Daegu 700-712 South KoreaYee Soo Chae, Kyungpook National University Hospital, Kyungpook National University School of Medicine Department of Hematology/Oncology 200 Dongduk-Ro, Jung-Gu Daegu 700-712 South KoreaJong Gwang Kim, K... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3304253 Tue, 23 Feb 2010 07:18:59 +0100 3304253 Bone marrow angiogenesis in multiple myeloma and its correlation with clinicopathological factors http://www.medworm.com/index.php?rid=3304252&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3747m85808237416%2F In this report we studied the various angiogenesis parameters like microvessel density (MVD) and total vascular area (TVA), on bone marrow biopsies in 50 newly diagnosed cases of MM. The aim was to study bone marrow angiogenesis in MM using light microscopy (MVD-A) and computerized image analyzer (MVD-B and TVA) and correlate it with clinical features, laboratory findings, histological features, and response to treatment on follow-up. Bone marrow biopsies of test cases (n = 50) were immunohistochemically stained with CD34 for visualization of microvessels. MVD-A (range 8–80; mean 50.4; SD 17.5), MVD-B (5.2–33.2; mean 16.3; SD 5.1), and TVA in percentage (range 0.42–7.20; mean 2.8; SD 1.5) were measured. Ten age- and sex-matched controls were studied and their parameters wer... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3304252 Tue, 23 Feb 2010 07:18:59 +0100 3304252 Severe coagulation disorder with hypofibrinogenemia associated with the use of tigecycline http://www.medworm.com/index.php?rid=3296085&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F854051l2422x7302%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0911-7Authors Herwig Pieringer, General Hospital Linz 2nd Department of Medicine, Section of Nephrology Krankenhausstr. 9 Linz 4020 AustriaBernhard Schmekal, General Hospital Linz 2nd Department of Medicine, Section of Nephrology Krankenhausstr. 9 Linz 4020 AustriaGeorg Biesenbach, General Hospital Linz 2nd Department of Medicine, Section of Nephrology Krankenhausstr. 9 Linz 4020 AustriaErich Pohanka, General Hospital Linz 2nd Department of Medicine, Section of Nephrology Krankenhausstr. 9 Linz 4020 Austria Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3296085 Sat, 20 Feb 2010 06:49:01 +0100 3296085 Hypothesis: upfront use of ABL kinase inhibitor combination, either simultaneously or sequentially, in high-risk Ph+ leukemias? http://www.medworm.com/index.php?rid=3285474&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu2hk601367330005%2F Abstract  A sequential treatment approach is the rule in CML and Ph+ ALL with imatinib failure being followed by second-line tyrosine kinase inhibitors. The sequential strategy may be vulnerable to compound mutations. An alternative and fascinating hypothesis discussed in this paper is the upfront use, at least in very high-risk Ph+ leukemias, of ABL kinase inhibitor combinations, either simultaneously or sequentially to target a wider range of mutations-based drug resistance. The main questions are: will TKI cocktails be able to eliminate the leukemic compartment? Which are the correct doses? Which are the long-term effects? Clinical trials have been recently initiated, and the future will give us the answer to all these questions. Content Type Journal ArticleCategory ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3285474 Wed, 17 Feb 2010 18:27:29 +0100 3285474 Assessment of immunogenicity of romiplostim in clinical studies with ITP subjects http://www.medworm.com/index.php?rid=3274020&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F086u34473u3427j1%2F Abstract  Romiplostim is an Fc-peptide fusion protein that activates intracellular transcriptional pathways via the thrombopoietin (TPO) receptor leading to increased platelet production. Romiplostim has been engineered to have no amino acid sequence homology to endogenous TPO. Recombinant protein therapeutics can be at a risk of development of an antibody response that can impact efficacy and safety. Hence, a strategy to detect potential antibody formation to the drug and to related endogenous molecules can be useful. The immunogenicity assessment strategy involved both the detection and characterization of binding and neutralizing antibodies. The method for detection was based on a surface plasmon resonance biosensor platform using the Biacore 3000. Samples that tested po... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3274020 Sat, 13 Feb 2010 06:45:56 +0100 3274020 Traumatic subcapsular splenic hematoma revealing littoral cell angioma and Gaucher’s disease http://www.medworm.com/index.php?rid=3274021&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F725542534q126g6g%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0909-1Authors Fabien Forest, Centre Hospitalier Universitaire de Saint-Etienne Department of Pathology Saint-Etienne FranceSébastien Duband, Centre Hospitalier Universitaire de Saint-Etienne Department of Pathology Saint-Etienne FranceAlix Clemenson, Centre Hospitalier Universitaire de Saint-Etienne Department of Pathology Saint-Etienne FranceMichel Peoc’h, Centre Hospitalier Universitaire Service d’Anatomie pathologique Hôpital Bellevue 420055 Saint-Etienne Cedex 02 France Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3274021 Sat, 13 Feb 2010 06:45:55 +0100 3274021 A retrospective study on 226 polycythemia vera patients: impact of median hematocrit value on clinical outcomes and survival improvement with anti-thrombotic prophylaxis and non-alkylating drugs http://www.medworm.com/index.php?rid=3264393&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2411ww1152148518%2F Abstract  The clinical impact of polycythemia vera (PV) diagnostic and therapeutic guidelines is still undetermined. In particular, the recommended target of hematocrit (Hct) <0.45 has been recently questioned and alkylating drugs are still used for elderly patients. We revised, according to WHO criteria, 300 PV diagnosis and evaluated the impact on clinical outcome of median Hct and of the strategy to administer anti-thrombotic prophylaxis and to avoid alkylating chemotherapy in almost all patients. Of 226 patients with WHO-confirmed diagnosis (median age 66), 91.3% survived at the median follow-up of 5.84 years and 77.5% are projected alive at 13 years. Eighteen percent had major thrombosis and 2.7% acute myeloid leukemia. Twenty-two percent of patients maint... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3264393 Tue, 09 Feb 2010 17:35:20 +0100 3264393 Coexistence of thyroid metastasis carcinoma in the background of HT and primary thyroid mucosa-associated lymphoid tissue B cell lymphoma in a thyroid gland http://www.medworm.com/index.php?rid=3264394&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq946078614686220%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0906-4Authors Bin Li, Xiangya Hospital, Central South University Division of Oncology Xiangya Road 87# Changsha Hunan 410008 People’s Republic of ChinaYouhong Tang, Xiangya Hospital, Central South University Division of Oncology Xiangya Road 87# Changsha Hunan 410008 People’s Republic of ChinaDesheng Xiao, Xiangya Hospital, Central South University Division of Pathology Xiangya Road 87# Changsha Hunan 410008 People’s Republic of ChinaMeizuo Zhong, Xiangya Hospital, Central South University Division of Oncology Xiangya Road 87# Changsha Hunan 410008 People’s Republic of China Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3264394 Mon, 08 Feb 2010 17:28:18 +0100 3264394 Human promoter mutations unveil Oct-1 and GATA-1 opposite action on Gfi1b regulation http://www.medworm.com/index.php?rid=3264395&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy7h17815j3j201q5%2F This study provides evidences of a new mechanism for Gfi1b repression. This is also the first report of Gfi1b mutations with a functional implication; further investigation and follow-up will clarify the involvement of these mutations in hematological disease. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0900-xAuthors Aurora Hernández, University Complutense Hematology Department, Hospital Clinico San Carlos 28040 Madrid SpainAna Villegas, University Complutense Hematology Department, Hospital Clinico San Carlos 28040 Madrid SpainEduardo Anguita, University Complutense Hematology Department, Hospital Clinico San Carlos 28040 Madrid Spain Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3264395 Mon, 08 Feb 2010 17:28:17 +0100 3264395 Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma http://www.medworm.com/index.php?rid=3241381&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F55761345x113p5pp%2F Abstract  The data about the fatty acid (FA) status of non-Hodgkin lymphoma (NHL) patients are poor. Therefore, the aim of this study was to investigate the FA profile of serum phospholipids in NHL patients related to the aggressiveness and clinical stage of NHL. We analyzed the FA profile of serum phospholipids in 47 newly diagnosed, untreated NHL patients and in 29 healthy subjects. Significantly higher (p < 0.001) levels of palmitic (16:0), oleic (18:1 n-9) and arachidonic acids (20:4 n-6), saturated and monounsaturated FA were found in NHL patients, while linoleic acid (18:2 n-6) and the levels of total polyunsaturated FA (PUFA), n-3 PUFA, eicosapentaenoic (20:5 n-3) and docosahexaenoic (DHA, 22:6 n-3) were significantly reduced (p < 0.01). The level of ole... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3241381 Tue, 02 Feb 2010 17:46:52 +0100 3241381 Hyperlipidemic myeloma http://www.medworm.com/index.php?rid=3233252&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk6qh7q926q560468%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0905-5Authors Alessandro Gozzetti, University of Siena Division of Hematology and Transplants, Policlinico “Santa Maria alle Scotte” Viale Bracci 16 53100 Siena ItalyMarzia Defina, University of Siena Division of Hematology and Transplants, Policlinico “Santa Maria alle Scotte” Viale Bracci 16 53100 Siena ItalyMonica Bocchia, University of Siena Division of Hematology and Transplants, Policlinico “Santa Maria alle Scotte” Viale Bracci 16 53100 Siena ItalyFrancesco Lauria, University of Siena Division of Hematology and Transplants, Policlinico “Santa Maria alle Scotte” Viale Bracci 16 53100 Siena Italy Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annal... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3233252 Mon, 01 Feb 2010 18:02:13 +0100 3233252 Ciprofloxacin-induced acute haemolytic anaemia in a patient with glucose-6-phosphate dehydrogenase Mediterranean deficiency: a case report http://www.medworm.com/index.php?rid=3233251&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu0l1881nj85k8264%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0903-7Authors Stefano Sansone, Central Hospital of Bolzano Division of Internal Medicine Lorenz-Böhler Street 5 39100 Bolzano ItalyJohanna Rottensteiner, Central Hospital of Bolzano Division of Internal Medicine Lorenz-Böhler Street 5 39100 Bolzano ItalyJudith Stocker, Central Hospital of Bolzano Division of Oncology Lorenz-Böhler Street 5 39100 Bolzano ItalyCarlo Rosanelli, Central Hospital of Bolzano Division of Hematology and Bone Marrow Transplantation Lorenz-Böhler Street 5 39100 Bolzano ItalyChristian Josef Wiedermann, Central Hospital of Bolzano Division of Internal Medicine Lorenz-Böhler Street 5 39100 Bolzano Italy Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (S... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3233251 Mon, 01 Feb 2010 18:02:13 +0100 3233251 Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells http://www.medworm.com/index.php?rid=3233253&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F23513g747211n816%2F Abstract  Treatment of acute myeloid leukemia (AML) remains challenging with many patients harboring unfavorable prognostic parameters such as FLT3 internal tandem duplication (FLT3-ITD) mutations leading to a constitutively activated FLT3-receptor tyrosine kinase (RTK). Activation of proteins by phosphorylation of tyrosine residues is a common mechanism in leukemia development. Therefore, specific tyrosine kinase inhibitors (TKI) have been developed for AML therapy and are currently under investigation. The staurosporine derivate PKC412 (Midostaurin) was found to be an effective inhibitor of the FLT3-RTK and is currently undergoing clinical trials for FLT3-mutated AML patients. Since resistance towards TKIs has been observed in vitro and in clinical trials, we have generated... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3233253 Mon, 01 Feb 2010 06:45:51 +0100 3233253 Chemotherapy-induced mesenchymal stem cell damage in patients with hematological malignancy http://www.medworm.com/index.php?rid=3229136&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp3586n8464126743%2F This study demonstrates a significant reduction in MSC expansion and MSC CD44 expression by MSCs derived from patients receiving HDC regimens, thus implicating potential disadvantages in the use of autologous MSCs in chemotherapeutically pretreated patients for future therapeutic strategies. The clinical importance of these HDC-induced defects we have observed could be determined through prospective randomized trials of the effects of MSC cotransplantation on hematopoietic recovery in the setting of HDC with and without hematopoietic stem cell rescue. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0896-2Authors Kevin Kemp, University of the West of England Center for Research in Biomedicine, Faculty of Applied Sciences Bristol UKRuth Morse, University ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3229136 Fri, 29 Jan 2010 17:57:51 +0100 3229136 Serological response to influenza vaccine after hematopoetic stem cell transplantation http://www.medworm.com/index.php?rid=3229135&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy50u0rk14m073803%2F In conclusion, the patients should be vaccinated as early as possible in the influenza season, before they are exposed to the virus. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0897-1Authors S. Songül Yalçın, Hacettepe University Unit of Social Pediatrics, Department of Pediatrics, Faculty of Medicine 06100 Ankara TurkeyMeda Kondolot, Hacettepe University Unit of Social Pediatrics, Department of Pediatrics, Faculty of Medicine 06100 Ankara TurkeyNurhan Albayrak, Virology Unit of Refik Saydam Hıfzıssıha Center Ankara TurkeyA. Başak Altaş, Virology Unit of Refik Saydam Hıfzıssıha Center Ankara TurkeyYasemin Karacan, Hacettepe University Unit of Hematopoetic Stem Cell Transplantation, Department of Internal Medicine, Faculty of Medicine Ankara ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3229135 Fri, 29 Jan 2010 17:57:51 +0100 3229135 Areas with high soil percolation by herbicides have higher incidence of low-grade non-Hodgkin lymphomas http://www.medworm.com/index.php?rid=3224062&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh81748470242p0t2%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0898-0Authors Rita Fazzi, University of Pisa Division of Hematology, Department of Oncology, Transplants and Advances in Medicine Pisa ItalyChiara Manetti, Division of Oncology, Azienda Ospedaliera Lucca Lucca ItalyDaniele Focosi, University of Pisa Division of Hematology, Department of Oncology, Transplants and Advances in Medicine Pisa ItalyLucia Miligi, Environmental and Occupational Epidemiology Institute for Study and Cancer Prevention, ISPO Florence ItalyAlessandra Benvenuti, Environmental and Occupational Epidemiology Institute for Study and Cancer Prevention, ISPO Florence ItalyEnrico Bonari, Scuola Superiore di Studi Universitari e Perfezionamento Sant’Anna Pisa ItalyRoberto Barale, University of... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3224062 Thu, 28 Jan 2010 17:59:35 +0100 3224062 Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain http://www.medworm.com/index.php?rid=3224063&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3g7858087884t624%2F Abstract  Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption. Dietary quality, alcoholism and other life-style factors can increase the risk of iron overload, especially among genetically at risk populations. Polymorphisms of the HFE gene (C282Y, H63D and S65C) were measured together with serum ferritin (SF), transferrin saturation (TS) and hemoglobin, to measure iron status, in randomly-selected healthy subjects living in the Spanish Mediterranean coast (n = 815; 425 females, 390 males), 18 to 75 years of age. The intake of dietary components that affect iron absorption was calculated from 3-day dietary records. The presence of C282Y/H... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3224063 Wed, 27 Jan 2010 20:24:47 +0100 3224063 Two case reports of non-secretary-Ig types of lymphoplasmacytic lymphoma (LPL) http://www.medworm.com/index.php?rid=3224064&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft3158514q5567238%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-010-0902-8Authors Kichinosuke Kobayashi, Osaka Medical College Department of Internal Medicine (I) 2-7 Daigakumachi Takatsuki Osaka 569-0801 JapanTaiji Yokote, Osaka Medical College Department of Internal Medicine (I) 2-7 Daigakumachi Takatsuki Osaka 569-0801 JapanYuji Hirata, Osaka Medical College Department of Internal Medicine (I) 2-7 Daigakumachi Takatsuki Osaka 569-0801 JapanShoko Nakayama, Osaka Medical College Department of Internal Medicine (I) 2-7 Daigakumachi Takatsuki Osaka 569-0801 JapanNobuya Hiraoka, Osaka Medical College Department of Internal Medicine (I) 2-7 Daigakumachi Takatsuki Osaka 569-0801 JapanAyami Takayama, Osaka Medical College Department of Internal Medicine (I) 2-7 Daigakumachi Taka... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3224064 Wed, 27 Jan 2010 20:24:46 +0100 3224064 Increased osteoclastic activity as shown by increased sRANK-L/OPG ratio in boys with hemophilia http://www.medworm.com/index.php?rid=3190978&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx774142g70711706%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0894-4Authors Athanasios Christoforidis, Aristotle University of Thessaloniki First Paediatric Department 59, Konstantinoupoleos Str 54642 Thessaloniki GreeceMarina Economou, Aristotle University of Thessaloniki First Paediatric Department 59, Konstantinoupoleos Str 54642 Thessaloniki GreeceEvangelia Farmaki, Aristotle University of Thessaloniki First Paediatric Department 59, Konstantinoupoleos Str 54642 Thessaloniki GreeceVasiliki Tzimouli, Aristotle University of Thessaloniki First Paediatric Department 59, Konstantinoupoleos Str 54642 Thessaloniki GreeceNikos Gombakis, Aristotle University of Thessaloniki First Paediatric Department 59, Konstantinoupoleos Str 54642 Thessaloniki GreeceMiranda Athanassiou... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3190978 Mon, 18 Jan 2010 18:44:18 +0100 3190978 T-cell large granular lymphocyte leukemia: an Asian perspective http://www.medworm.com/index.php?rid=3190979&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnn35537m03px2m2l%2F Abstract  To characterize T-cell large granular leukemia in Asia, 22 Chinese patients from a single institute were reported, together with an analysis of 88 Asian and 272 Western patients identified from the literature. In our cohort, anemia due to pure red cell aplasia (PRCA) occurred in 15/22 (68%) of cases, being the most common indication for treatment. Neutropenia was only found in 8/22 (36%) cases, and recurrent infections, the most important clinical problem in Western patients, were not observed. None of our cases presented with rheumatoid arthritis. These clinical features were consistently observed when compared with the 88 other Asian patients. Combined data from our cohort and other Asian cases showed that Asian patients, compared with Western patients, had more... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3190979 Mon, 18 Jan 2010 18:44:17 +0100 3190979 Poor potential of proliferation and differentiation in bone marrow mesenchymal stem cells derived from children with severe aplastic anemia http://www.medworm.com/index.php?rid=3190980&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe14061q5t562r015%2F Abstract  The pathogenesis of severe aplastic anemia (SAA) has not been completely understood, and insufficiency of the hematopoietic microenvironment can be an important factor. Here, we compared the basic properties of mesenchymal stem cells (MSCs), a major component of bone marrow microenvironment, from five SAA children with those of MSCs from five controls. Although MSCs from SAA children and controls were similar in morphology and immunophenotypic profile, SAA MSCs had slower expansion rate and smaller cumulative population doubling (1.83 ± 1.21 vs 3.36 ± 0.87; p = 0.046), indicating lower proliferative capacity. After osteogenic induction, SAA MSCs showed lower alkaline phosphatase activity (optical density, 1.46 ± 0.04 vs 2.27 ± 0.32; p = ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3190980 Mon, 18 Jan 2010 18:44:16 +0100 3190980 Pancytopenia and severe sepsis in an adult case of congenital X-linked agammaglobulinemia (XLA) http://www.medworm.com/index.php?rid=3190981&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl750t46242l0q324%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0891-7Authors Andrea Tendas, Sant’Eugenio Hospital Hematology Unit Rome ItalyPasquale Niscola, Sant’Eugenio Hospital Hematology Unit Rome ItalyTeresa Dentamaro, Sant’Eugenio Hospital Hematology Unit Rome ItalyLuca Cupelli, Sant’Eugenio Hospital Hematology Unit Rome ItalyGigliola Di Matteo, Tor Vergata University Department of Public Health Rome ItalyAndrea Finocchi, Tor Vergata University Department of Public Health Rome ItalyAgostina Siniscalchi, Sant’Eugenio Hospital Hematology Unit Rome ItalyStefano Fratoni, Sant’Eugenio Hospital Pathology Department Rome ItalyTeresa Scimò, Sant’Eugenio Hospital Hematology Unit Rome ItalyLaura Scaramucci, Sant’Eugenio Hospital Hematology Unit Rome ItalyM... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3190981 Fri, 15 Jan 2010 00:41:40 +0100 3190981 Protein C (PROC) gene mutations in two Indian families with purpura fulminans http://www.medworm.com/index.php?rid=3190982&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F48n7150560v2125v%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0893-5Authors Navin Pai, National Institute of Immunohaematology (ICMR) Department of Haemostasis and Thrombosis 13th Floor, KEM Hospital, Parel Mumbai 400 012 IndiaShrimati Shetty, National Institute of Immunohaematology (ICMR) Department of Haemostasis and Thrombosis 13th Floor, KEM Hospital, Parel Mumbai 400 012 IndiaKanjaksha Ghosh, National Institute of Immunohaematology (ICMR) Department of Haemostasis and Thrombosis 13th Floor, KEM Hospital, Parel Mumbai 400 012 India Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3190982 Fri, 15 Jan 2010 00:41:39 +0100 3190982 Pneumocystis jiroveci pneumonia detected by FDG-PET http://www.medworm.com/index.php?rid=3169145&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvx128630v7718613%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0888-2Authors Tomonori Nakazato, Yokohama Municipal Citizen’s Hospital Department of Hematology 56 Okazawa-cho, Hodogaya-ku Yokohama 240-8555 JapanAi Mihara, Yokohama Municipal Citizen’s Hospital Department of Hematology 56 Okazawa-cho, Hodogaya-ku Yokohama 240-8555 JapanYukinari Sanada, Yokohama Municipal Citizen’s Hospital Department of Hematology 56 Okazawa-cho, Hodogaya-ku Yokohama 240-8555 JapanKazuhito Suzuki, Yokohama Municipal Citizen’s Hospital Department of Hematology 56 Okazawa-cho, Hodogaya-ku Yokohama 240-8555 JapanYoshinobu Aisa, Yokohama Municipal Citizen’s Hospital Department of Hematology 56 Okazawa-cho, Hodogaya-ku Yokohama 240-8555 JapanMichio Iwabuchi, Yokohama Municipal Citize... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3169145 Mon, 11 Jan 2010 18:19:40 +0100 3169145 Expression of pSTAT5 predicts FLT3 internal tandem duplications in acute myeloid leukemia http://www.medworm.com/index.php?rid=3169146&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcm74534458478507%2F Abstract  Mutations of the Fms-like tyrosine kinase 3 (FLT3) can be detected in a significant number of acute myeloid leukemias (AML). Seventy-five cases of acute myeloid leukemia were evaluated for FLT3-internal tandem duplications (ITD) by polymerase chain reaction. Paraffin-embedded formalin-fixed trephine biopsies of these cases were evaluated for expression of phosphorylated signal transducer and activator of transcription 1 (pSTAT1), pSTAT3, and pSTAT5. Specific expression of pSTAT5 was proven in leukemic blasts in situ by double staining with a blast-specific marker. Expression of pSTAT5 in ≥1% of blasts was highly predictive of FLT3-ITD. Neither expression of pSTAT1 nor pSTAT3 were associated with FLT3 mutations. Altogether we conclude that pSTAT5 expression can pre... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3169146 Mon, 11 Jan 2010 18:19:39 +0100 3169146 Shedding of the endothelial receptor tyrosine kinase Tie2 correlates with leukemic blast burden and outcome after allogeneic hematopoietic stem cell transplantation for AML http://www.medworm.com/index.php?rid=3154645&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F35h257423w667807%2F Abstract  Angiogenesis plays an important role in the growth and viability of hematologic malignancies. Emerging data suggest a crucial involvement of the endothelial-specific Tie2 receptor and its antagonistic ligand Angiopoietin-2 (Ang-2) in this process. The purpose of this study was to elucidate whether the soluble domain of the Tie2 receptor (sTie2) predicts outcome in patients with acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Serum levels of sTie2 and Ang-2 were measured by ELISA in 181 AML patients before conditioning for HSCT. The median follow-up time was 22 months after HSCT. Pre-HSCT sTie2 levels were significantly higher in patients (median 2.2 (range 1.8–3.0) ng/mL) compared to healthy controls (... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3154645 Wed, 06 Jan 2010 18:04:27 +0100 3154645 Acquired haemophilia caused by non-haemophilic factor VIII gene variants http://www.medworm.com/index.php?rid=3154644&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb212g463k8062w73%2F In conclusion, encounter of variant allogeneic FVIII presented on a suitable MHC background could be a risk factor for inhibitor formation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0887-3Authors Andreas Tiede, Hannover Medical School Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation Feodor Lynen Str. 5 30625 Hannover GermanyRoswith Eisert, Hannover Medical School Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation Feodor Lynen Str. 5 30625 Hannover GermanyAndreas Czwalinna, Hannover Medical School Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation Feodor Lynen Str. 5 30625 Hannover GermanyWolfgang Miesbach, University Hospital Frankfurt Department of Internal Medicin... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3154644 Wed, 06 Jan 2010 18:04:27 +0100 3154644 Assessment of clopidogrel non-response by the PFA-100® system using the new test cartridge INNOVANCE® PFA P2Y http://www.medworm.com/index.php?rid=3154646&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn105876k3225x61t%2F Abstract  Until now, the PFA-100® system has been considered unsuitable for monitoring clopidogrel efficacy. The authors evaluated platelet function in peripheral arterial occlusive disease (PAOD) patients using a new PFA-100® test cartridge (product name: INNOVANCE® PFA P2Y*) specifically designed for this purpose. Twenty-two stable PAOD patients on antithrombotic therapy with clopidogrel alone (n = 22) and 18 patients undergoing a peripheral catheter intervention, preliminarily treated with 100 mg/day of aspirin followed by co-administration of clopidogrel (loading dose 300 mg, maintenance dose 75 mg/day), were enrolled in this study. Defining non-responsiveness to clopidogrel as an aggregation response within the reference range (90% central interval... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3154646 Mon, 04 Jan 2010 18:15:46 +0100 3154646 High versus standard dose methylprednisolone in the acute phase of idiopathic thrombotic thrombocytopenic purpura: a randomized study http://www.medworm.com/index.php?rid=3121473&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fuv503qw35u570275%2F Abstract  Therapeutic plasma exchange (PE) is the accepted therapy for thrombotic thrombocytopenic purpura (TTP). Because not all patients achieve remission, other treatment modalities have been used in addition to PE, but no randomized clinical trial evaluated their efficacy. The aim of this multicentric study was to compare the effectiveness of standard- versus high-dose methylprednisolone as an adjunctive treatment to PE in the acute phase of TTP. Sixty patients with idiopathic TTP were randomized to receive methylprednisolone 1 mg/kg/die intravenous or 10 mg/kg/die for 3 days, thereafter, 2.5 mg/kg/die in addition to PE. Both dosages of steroids were well tolerated. At the end of induction therapy (day 23), the percentage of patients failing to a... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3121473 Wed, 23 Dec 2009 22:13:32 +0100 3121473 Acquired Hb H disease associated with elevated Hb F level in patient affected by primary myelofibrosis http://www.medworm.com/index.php?rid=3106021&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx1x470v2176g4073%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0878-4Authors Ciro Roberto Rinaldi, University Federico II Hematology Division, Department of Biochemistry and Medical Biotechnology 80131 Naples ItalyPaola Rinaldi, University Federico II Hematology Division, Department of Biochemistry and Medical Biotechnology 80131 Naples ItalyFabrizio Pane, University Federico II Hematology Division, Department of Biochemistry and Medical Biotechnology 80131 Naples ItalyAndrea Camera, University Federico II Hematology Division, Department of Biochemistry and Medical Biotechnology 80131 Naples ItalyCarmine Rinaldi, Laboratorio di Biologica Molecolare P.O. Marcianise ASL Caserta Caserta Italy Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (So... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3106021 Fri, 18 Dec 2009 16:36:44 +0100 3106021 Imatinib, cytokines and interstitial lung disease in a patient with primary myelofibrosis http://www.medworm.com/index.php?rid=3106022&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn204kg426845q50x%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0884-6Authors Bruno Robibaro, Medical University Vienna Division of Pulmonary Medicine Waehringer Guertel 18-20 1090 Vienna AustriaAnna Kropfmueller, Medical University Vienna Division of Pulmonary Medicine Waehringer Guertel 18-20 1090 Vienna AustriaMathias Prokop, University Medical Center Utrecht Department of Radiology Heidelberglaan 100 3584 CX Utrecht The NetherlandsPaul Haber, Medical University Vienna Division of Pulmonary Medicine Waehringer Guertel 18-20 1090 Vienna AustriaHeinz Gisslinger, Medical University Vienna Division of Hematology and Blood Coagulation Waehringer Guertel 18-20 1090 Vienna Austria Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals o... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3106022 Fri, 18 Dec 2009 16:36:43 +0100 3106022 Pulmonary marginal zone B-cell lymphoma of MALT type—What is a prognostic factor and which is the optimal treatment, operation, or chemotherapy?: Consortium for Improving Survival of Lymphoma (CISL) Study http://www.medworm.com/index.php?rid=3106023&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F631j10hw007264v0%2F Abstracts  Pulmonary marginal zone B-cell lymphoma of the MALT type (P-MZL) is a relatively rare form of lymphoma. We conducted a retrospective analysis of the clinical features and treatment outcomes of P-MZL for the evaluation of prognostic factors, and to collect information about the optimal treatment modality for this condition. From 1991 to 2008, a total of 61 patients with biopsy-confirmed P-MZL were retrospectively analyzed. The median age of our subjects was 60 (range, 34–79) years. Twenty-five of the patients (41%) were initially diagnosed without any symptoms. Video-assisted thoracic surgery was utilized for diagnosis in 19 patients (31%). Thirty-eight patients' conditions (62%) involved a single lobe. Lung lesions were bilateral in 15 patients (25%). Eleven pa... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3106023 Fri, 18 Dec 2009 16:36:42 +0100 3106023 CTLA-4 +49A>G polymorphism of recipients of HLA-matched sibling allogeneic stem cell transplantation is associated with survival and relapse incidence http://www.medworm.com/index.php?rid=3106024&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft151tk97u5822x82%2F Abstract  Conflicting observations have been reported about the role of CTLA-4 gene polymorphisms in the clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT). We have investigated three polymorphisms of the CTLA-4 gene (−318C>T, +49A>G, CT60G>A) in 133 donor/recipient pairs who underwent HLA-matched sibling donor HSCT for hematological malignancies. We found no association of the clinical outcome of the HSCT with either recipient or donor −318C>T and CT60G>A polymorphisms. At variance, we found a significant association of donor +49A>G G/G genotype with longer overall survival (OS; log-rank test, P = 0.04), and the number of +49A>G G-alleles in the recipient with longer OS (P = 0.027), longer disease-free survival (P... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3106024 Fri, 18 Dec 2009 07:05:45 +0100 3106024 The role of chemokines in B cell chronic lymphocytic leukaemia: pathophysiological aspects and clinical impact http://www.medworm.com/index.php?rid=3106025&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa18271285u544280%2F Abstract  Chemokines are centrally involved in leukocyte migration, homing and haematopoiesis. Besides these physiological aspects, their role in pathological processes especially with respect to solid tumour and haematological neoplasias is well established. In this context, the focus was set here on disclosing their contribution in B cell chronic lymphocytic leukaemia (B-CLL), which is regarded as the most characteristic low-grade lymphoma. Up to now, it has been demonstrated that several chemokines are involved in migration of B-CLL cells to lymph nodes, secondary lymphoid organs and bone marrow. Moreover, some chemokines are known to have an anti-apoptotic effect and thus contribute to the survival of B-CLL cells. By interfering with both of these aspects, new therapeut... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3106025 Fri, 18 Dec 2009 07:05:44 +0100 3106025 Absence of cardiac siderosis despite hepatic iron overload in Italian patients with thalassemia intermedia: an MRI T2* study http://www.medworm.com/index.php?rid=3106026&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F24651017300750q2%2F Abstract  Cardiac involvement in patients with thalassemia intermedia (TI) is characterized by a high-output state and pulmonary hypertension, with systolic left ventricle function usually being preserved. Myocardial iron overload in patients with TI has not been extensively studied. We conducted a cross-sectional study of 49 Italian patients with TI. Patient charts were reviewed and data collected for transfusion and iron chelation history, status of the spleen, and comorbid illnesses or infections. Blood samples were obtained for assessment of hemoglobin, serum ferritin, and liver enzyme levels. Doppler echocardiography was done for all patients. Cardiac and hepatic iron levels were measured by magnetic resonance imaging T2*. The mean age was 40.5 ± 8.3 years, w... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3106026 Thu, 17 Dec 2009 07:02:47 +0100 3106026 Monoclonal gammopathy of undetermined significance related pyoderma gangrenosum successfully treated with autologous peripheral blood stem cell transplantation http://www.medworm.com/index.php?rid=3098193&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F925r771777324n41%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0880-xAuthors Ching-Ming Chang, Taichung Veterans General Hospital Division of Hematology/Oncology, Department of Medicine 160, Section 3, Chungkang Road Taichung 407 Taiwan Republic of ChinaWen-Lee Hwang, Taichung Veterans General Hospital Division of Hematology/Oncology, Department of Medicine 160, Section 3, Chungkang Road Taichung 407 Taiwan Republic of ChinaZu-Yi Hsieh, Taichung Veterans General Hospital Division of Immunology, Department of Medicine Taichung Taiwan Republic of ChinaRen-Ching Wang, Taichung Veterans General Hospital Department of Pathology Taichung Taiwan Republic of ChinaChieh-Lin Teng, Taichung Veterans General Hospital Division of Hematology/Oncology, Department of Medicine 160, S... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3098193 Tue, 15 Dec 2009 06:46:20 +0100 3098193 The clinicopathological analysis of 303 cases with malignant lymphoma classified according to the World Health Organization classification system in a single institute of Taiwan http://www.medworm.com/index.php?rid=3086681&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr971wk422p787142%2F Abstract  Several reports have shown a different distribution of malignant lymphoma (ML) in Asian and Western populations. The purpose of our survey was to elucidate whether there are substantial differences in the frequencies of subtypes of ML between different geographical areas. All entities diagnosed as ML between June 1995 and December 2007 were selected according to the 2008 World Health Organization (WHO) classification and searched for clinical outcomes. The cases were retrieved and reviewed by a panel of clinical haematologists and haematopathologists. A total of 303 patients with ML were identified for retrospective analysis. Of the 303 patients with ML, 278 patients (91.7%) had non-Hodgkin’s lymphoma (NHL), and 25 (9.2%) had Hodgkin’s lymphoma. Of the 278 pat... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3086681 Fri, 11 Dec 2009 06:52:02 +0100 3086681 Short and long-term outcome of treatment with high-dose melphalan and stem cell transplantation for multiple myeloma-associated AL amyloidosis http://www.medworm.com/index.php?rid=3086682&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft65r5280982086n3%2F In conclusion, HDM/SCT can prolong overall survival in patients with MM/AL who are eligible to receive it. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0874-8Authors Saulius Girnius, Boston University School of Medicine Amyloid Treatment and Research Program Boston MA USADavid C. Seldin, Stem Cell Transplantation Program of the Section of Hematology-Oncology FGH 1007, 820 Harrison Avenue Boston MA 02118 USAMartha Skinner, Boston University School of Medicine Amyloid Treatment and Research Program Boston MA USAKathleen T. Finn, Stem Cell Transplantation Program of the Section of Hematology-Oncology FGH 1007, 820 Harrison Avenue Boston MA 02118 USAKaren Quillen, Stem Cell Transplantation Program of the Section of Hematology-Oncology FGH 1007, 820 Harrison... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3086682 Thu, 10 Dec 2009 15:15:45 +0100 3086682 Hematoma of the iliopsoas muscle due to thrombocytopenia resulting from the administration of a third-generation cephalosporin http://www.medworm.com/index.php?rid=3086683&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj55k6430681818r6%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0872-xAuthors Makoto Onodera, Iwate Medical University Department of Critical Care Medicine 19-1 Uchimaru Morioka City Iwate 020-8505 JapanYasuhisa Fujino, Iwate Medical University Department of Critical Care Medicine 19-1 Uchimaru Morioka City Iwate 020-8505 JapanYoshihiro Inoue, Iwate Medical University Department of Critical Care Medicine 19-1 Uchimaru Morioka City Iwate 020-8505 JapanSatoshi Kikuchi, Iwate Medical University Department of Critical Care Medicine 19-1 Uchimaru Morioka City Iwate 020-8505 JapanShigeatsu Endo, Iwate Medical University Department of Critical Care Medicine 19-1 Uchimaru Morioka City Iwate 020-8505 Japan Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3086683 Thu, 10 Dec 2009 15:15:44 +0100 3086683 Bortezomib, thalidomide, dexamethasone induction therapy followed by melphalan, prednisolone, thalidomide consolidation therapy as a first line of treatment for patients with multiple myeloma who are non-transplant candidates: results of the Korean Multiple Myeloma Working Party (KMMWP) http://www.medworm.com/index.php?rid=3086684&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr4p0467830064n87%2F Abstract  Bortezomib (VELCADE®), thalidomide and dexamethasone (VTD), as well as melphalan, prednisolone, and thalidomide (MPT) therapy, are highly effective in patients with multiple myeloma. We evaluated the responses and survival times of 35 patients treated with VTD followed by MPT. All patients were newly diagnosed and non-transplantation candidates. Patients received six cycles of VTD, which were followed by eight cycles of MPT. Approximately 97% of patients exhibited early responses to therapy, as early as the second cycle of VTD. Thirty percent of the responses were high quality, which was defined as a complete response (CR), a near-CR or a very good partial response. High-risk patients were defined as patients with any of the following aberrations: del(13), t(4;14... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3086684 Thu, 10 Dec 2009 15:15:43 +0100 3086684 Bortezomib-based therapy as induction regimen of an autograft program in front-line treatment of multiple myeloma with end-stage renal disease http://www.medworm.com/index.php?rid=3064756&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe144m33678062t50%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0867-7Authors Agostina Siniscalchi, “Tor Vergata” University Department of Hematology, S. Eugenio Hospital Piazzale dell’Umanesimo, 10 00100 Rome ItalyTeresa Dentamaro, “Tor Vergata” University Department of Hematology, S. Eugenio Hospital Piazzale dell’Umanesimo, 10 00100 Rome ItalyAlessio Perrotti, “Tor Vergata” University Department of Hematology, S. Eugenio Hospital Piazzale dell’Umanesimo, 10 00100 Rome ItalyPaola Tatangelo, S. Eugenio Hospital Department of Nephrology Rome ItalyPaolo de Fabritiis, “Tor Vergata” University Department of Hematology, S. Eugenio Hospital Piazzale dell’Umanesimo, 10 00100 Rome ItalyTommaso Caravita, “Tor Vergata” University Department of Hematol... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3064756 Tue, 01 Dec 2009 20:57:07 +0100 3064756 Acquired factor XIII inhibitor in monoclonal gammopathy of undetermined significance: characterization and cross-linked fibrin ultrastructure http://www.medworm.com/index.php?rid=3064758&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5777781714860t14%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0868-6Authors Yunya Luo, Central South University Division of Hematology, Institute of Molecular Hematology, Second Xiang-ya Hospital Changsha Hunan 410011 People’s Republic of ChinaGuangsen Zhang, Central South University Division of Hematology, Institute of Molecular Hematology, Second Xiang-ya Hospital Changsha Hunan 410011 People’s Republic of ChinaWenli Zuo, Central South University Division of Hematology, Institute of Molecular Hematology, Second Xiang-ya Hospital Changsha Hunan 410011 People’s Republic of ChinaWenli Zheng, Central South University Division of Hematology, Institute of Molecular Hematology, Second Xiang-ya Hospital Changsha Hunan 410011 People’s Republic of ChinaChongwen Dai, C... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3064758 Tue, 01 Dec 2009 20:57:05 +0100 3064758 Imatinib and cardiac failure in idiopathic hypereosinophilic syndrome http://www.medworm.com/index.php?rid=3064757&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm1v14352v35j5876%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0866-8Authors Lisa Pieri, University of Florence UF di Ematologia, Dip. Area Critica Florence ItalyAlberto Bosi, University of Florence UF di Ematologia, Dip. Area Critica Florence ItalyAlessandro M. Vannucchi, University of Florence UF di Ematologia, Dip. Area Critica Florence Italy Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3064757 Tue, 01 Dec 2009 20:57:05 +0100 3064757 BAALC is an important predictor of refractoriness to chemotherapy and poor survival in intermediate-risk acute myeloid leukemia (AML) http://www.medworm.com/index.php?rid=3041473&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg041464u11784317%2F In conclusion, BAALC is a relevant prognostic marker in intermediate-risk AML. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0864-xAuthors Carlos Santamaría, Hospital Universitario Salamanca SpainMaría C. Chillón, Hospital Universitario Salamanca SpainRamón García-Sanz, Hospital Universitario Salamanca SpainCristina Pérez, Hospital Clínico San Carlos Madrid SpainMaría D. Caballero, Hospital Universitario Salamanca SpainMaría V. Mateos, Hospital Universitario Salamanca SpainFernando Ramos, Complejo Hospitalario de León and Ibiomed León SpainAlfonso García de Coca, Hospital Clínico de Valladolid Valladolid SpainJosé M. Alonso, Hospital Río Carrión de Palencia Palencia SpainPilar Giraldo, Hospital Miguel Servet Zaragoza SpainTeresa Bernal, Ho... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3041473 Fri, 27 Nov 2009 07:02:44 +0100 3041473 Congenital factor XIII deficiency caused by two mutations in eight Tunisian families: molecular confirmation of a founder effect http://www.medworm.com/index.php?rid=3032107&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F71m5l90vg172421g%2F We describe here molecular abnormalities found in nine Tunisian probands diagnosed with FXIIIA deficiency. The identification of the founder mutation and polymorphisms allowed a genetic counseling in relatives of these families, and the antenatal diagnosis is now available. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0863-yAuthors Nacim Louhichi, Faculty of Medicine of Sfax Human Molecular Genetic Laboratory Avenue Magida Boulila 3029 Sfax TunisiaMoez Medhaffar, Hédi Chaker de Sfax Service of Hematology. C.H.U Sfax TunisiaIkhlass HadjSalem, Faculty of Medicine of Sfax Human Molecular Genetic Laboratory Avenue Magida Boulila 3029 Sfax TunisiaEmna Mkaouar-Rebai, Faculty of Medicine of Sfax Human Molecular Genetic Laboratory Avenue Magida Boulila 3029 S... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3032107 Tue, 24 Nov 2009 07:09:07 +0100 3032107 Salvage treatment with upfront melphalan 100 mg/m2 and consolidation with novel drugs for fulminant progression of multiple myeloma http://www.medworm.com/index.php?rid=3098194&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa37nx3g76jr21p48%2F Abstract  Patients (pts) with fulminant progression (FPG) of multiple myeloma (MM) after autologous stem cell transplantation (ASCT) have poor prognosis. Pancytopenia, extramedullary disease, and/or renal impairment are often present, and treatment options are limited. We have retrospectively evaluated 31 pts with FPG of MM after ASCT who were treated upfront salvage therapy with melphalan 100 mg/m2 (MEL 100) followed by PBSC support and consolidation therapy using regimens containing thalidomide (n = 16) or bortezomib (n = 15). The overall response rate (ORR) was 58% (18/31). After MEL 100, one patient achieved complete remission (3%), 26% of pts very good partial remission, 29% of pts partial remission, and 42% of pts stable disease. Progression within 3 m... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3098194 Wed, 18 Nov 2009 19:15:05 +0100 3098194 Salvage treatment with upfront melphalan 100 mg/m2 and consolidation with novel drugs for fulminant progression of multiple myeloma http://www.medworm.com/index.php?rid=3016285&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa37nx3g76jr21p48%2F Abstract  Patients (pts) with fulminant progression (FPG) of multiple myeloma (MM) after autologous stem cell transplantation (ASCT) have poor prognosis. Pancytopenia, extramedullary disease, and/or renal impairment are often present, and treatment options are limited. We have retrospectively evaluated 31 pts with FPG of MM after ASCT who were treated upfront salvage therapy with melphalan 100 mg/m2 (MEL 100) followed by PBSC support and consolidation therapy using regimens containing thalidomide (n = 16) or bortezomib (n = 15). The overall response rate (ORR) was 58% (18/31). After MEL 100, one patient achieved complete remission (3%), 26% of pts very good partial remission, 29% of pts partial remission, and 42% of pts stable disease. Progression within 3 m... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3016285 Wed, 18 Nov 2009 19:15:05 +0100 3016285 Clinical efficacy of a bortezomib, cyclophosphamide, thalidomide, and dexamethasone (Vel-CTD) regimen in patients with relapsed or refractory multiple myeloma: a phase II study http://www.medworm.com/index.php?rid=3010190&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvh10216215244805%2F Abstract  The clinical efficacy and safety of a four-drug combination of bortezomib, cyclophosphamide, thalidomide, and dexamethasone was assessed for patients with relapsed or refractory multiple myeloma. Seventy patients received at least two cycles of treatment with bortezomib 1.3 mg/m2 intravenously on days 1, 4, 8, and 11; cyclophosphamide 150 mg/m2 orally on days 1–4; thalidomide 50 mg/day orally every day; and dexamethasone 20 mg/m2 intravenously on days 1, 4, 8, and 11. The overall best response rate was 88%, with 46% complete response, 9% very good partial response, and 33% partial response. After a median follow-up of 12.6 months, the median progression-free survival (PFS) was 14.6 months with a 3-year PFS of 14% and the median overal... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3010190 Wed, 18 Nov 2009 00:06:17 +0100 3010190 Erratum to: Results of FLT3 mutation screening and correlations with immunophenotyping in 169 Brazilian patients with acute myeloid leukemia http://www.medworm.com/index.php?rid=3010191&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc1232l6072r57428%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s00277-009-0860-1Authors Antonio R. Lucena-Araujo, University of São Paulo Hematology Division, Department of Internal Medicine, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirão Preto Ribeirão Preto BrazilDanielle L. Souza, University of São Paulo Hematology Division, Department of Internal Medicine, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirão Preto Ribeirão Preto BrazilFabio Morato de Oliveira, University of São Paulo Hematology Division, Department of Internal Medicine, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirão Preto Ribeirão Preto BrazilMariana Tereza Lira Benicio, Univer... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3010191 Wed, 18 Nov 2009 00:06:16 +0100 3010191 Cytogenetic features and prognosis analysis in Chinese patients with myelodysplastic syndrome: a multicenter study http://www.medworm.com/index.php?rid=3010193&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb3g1501v464w8167%2F In this study, we retrospectively analyzed clinical and cytogenetic data from 435 Chinese adult primary MDS patients. In addition, we evaluated the prognostic value of the World Health Organization classification as well as six prognostic scoring systems in these patients. The median follow-up time was 25.1 months (5.5–53.2). Of the 435 patients, 186 (42.8%) had died and 40 (9.2%) had progressed to acute myeloid leukemia. Multivariate analysis identified older age, higher percent of marrow blasts, and poor-risk IPSS cytogenetics as characteristics associated with worse survival and higher risk of leukemia transformation. Low platelets, hemoglobin, and mean corpuscular volume were independent factors associated only with worse survival. Among the 424 patients in whom the result... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3010193 Wed, 18 Nov 2009 00:06:14 +0100 3010193 Hyperlipidemic myeloma: review of 53 cases http://www.medworm.com/index.php?rid=3010192&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk64n070332355184%2F In conclusion, the clinical characteristics, the therapeutic options, and the pathophysiologic mechanisms of hyperlipidemic myeloma are comprehensively reported using the available data from all 53 published cases in the literature. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0849-9Authors Benjamin Misselwitz, University Hospital Zürich Department of Internal Medicine Rämistr. 100 8091 Zürich SwitzerlandJeroen S. Goede, University Hospital Zürich Clinic of Haematology Rämistr. 100 8091 Zürich SwitzerlandBernhard C. Pestalozzi, University Hospital Zürich Clinic of Oncology Rämistr. 100 8091 Zürich SwitzerlandUrs Schanz, University Hospital Zürich Clinic of Haematology Rämistr. 100 8091 Zürich SwitzerlandJörg D. Seebach, University Hospital... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=3010192 Wed, 18 Nov 2009 00:06:14 +0100 3010192 Jumping translocation involving 1q21 during long-term complete remission of acute myeloid leukemia http://www.medworm.com/index.php?rid=2986736&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv885420485646r38%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0855-yAuthors Sumimasa Nagai, University of Tokyo Department of Hematology and Oncology, Graduate School of Medicine 7-3-1, Hongo, Bunkyo-ku Tokyo 1138655 JapanYasuhito Nannya, University of Tokyo Department of Hematology and Oncology, Graduate School of Medicine 7-3-1, Hongo, Bunkyo-ku Tokyo 1138655 JapanTsuyoshi Takahashi, University of Tokyo Department of Hematology and Oncology, Graduate School of Medicine 7-3-1, Hongo, Bunkyo-ku Tokyo 1138655 JapanMineo Kurokawa, University of Tokyo Department of Hematology and Oncology, Graduate School of Medicine 7-3-1, Hongo, Bunkyo-ku Tokyo 1138655 Japan Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2986736 Tue, 10 Nov 2009 18:44:47 +0100 2986736 ABO discrepancy in an elderly patient with IgA kappa-type multiple myeloma http://www.medworm.com/index.php?rid=2986735&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv67296576l84313m%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0858-8Authors So Young Kim, Kyung Hee University School of Medicine Department of Laboratory Medicine 1 Hoegi-dong, Dongdaemun-gu Seoul 130-702 Republic of KoreaSeung Hwan Oh, Inje University College of Medicine Department of Laboratory Medicine Gaegeum-dong, Busanjin-gu Busan 614-735 Republic of KoreaKyung Sun Park, Kyung Hee University School of Medicine Department of Laboratory Medicine 1 Hoegi-dong, Dongdaemun-gu Seoul 130-702 Republic of KoreaMin Jin Kim, Kyung Hee University School of Medicine Department of Laboratory Medicine 1 Hoegi-dong, Dongdaemun-gu Seoul 130-702 Republic of KoreaGayoung Lim, Kyung Hee University School of Medicine Department of Laboratory Medicine 1 Hoegi-dong, Dongdaemun-gu Seo... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2986735 Tue, 10 Nov 2009 18:44:47 +0100 2986735 Acquired erythropoietic protoporphyria http://www.medworm.com/index.php?rid=2982817&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F34jv277qu7611408%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0859-7Authors Daniel Blagojevic, Landesklinikum St. Poelten Karl Landsteiner Institute for Dermatological Research St. Poelten AustriaThomas Schenk, Landesklinikum St. Poelten Department of Internal Medicine I St. Poelten AustriaOskar Haas, Ambulatorium Medgen Vienna AustriaBrigitte Zierhofer, Landesklinikum St. Poelten Karl Landsteiner Institute for Dermatological Research St. Poelten AustriaChristophoros Konnaris, Medical University of Vienna Department of Gynecology and Obstetrics Vienna AustriaFranz Trautinger, Landesklinikum St. Poelten Karl Landsteiner Institute for Dermatological Research St. Poelten Austria Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2982817 Mon, 09 Nov 2009 19:12:29 +0100 2982817 Resolution of invasive fungal sinusitis in immunocompromised patients: neutrophil count is crucial beside a combined medical and surgical approach http://www.medworm.com/index.php?rid=2971526&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk30hn7v118053j54%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0854-zAuthors Patrizia Zappasodi, Foundation IRCCS Policlinico San Matteo, University of Pavia Division of Haematology 27100 Pavia ItalyMarianna Rossi, Foundation IRCCS Policlinico San Matteo, University of Pavia Division of Haematology 27100 Pavia ItalyCarlo Castagnola, Foundation IRCCS Policlinico San Matteo, University of Pavia Division of Haematology 27100 Pavia ItalyFabio Pagella, Foundation IRCCS Policlinico San Matteo, University of Pavia Department of Otorhinolaryngology Pavia ItalyElina Matti, Foundation IRCCS Policlinico San Matteo, University of Pavia Department of Otorhinolaryngology Pavia ItalyCaterina Cavanna, Foundation IRCCS Policlinico San Matteo, University of Pavia Virology and Microbiolo... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2971526 Fri, 06 Nov 2009 18:55:30 +0100 2971526 Amyloid in bone marrow smears of patients affected by multiple myeloma http://www.medworm.com/index.php?rid=2971527&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9k8v1132284v32p4%2F Abstract  Systemic AL amyloidosis is associated with nearly 15% of cases of multiple myeloma, but data on the frequency and significance of amyloid deposits in the bone marrow of patients affected by multiple myeloma without clinical signs of systemic amyloidosis are scanty. Bone marrow smears of 166 unselected patients affected by multiple myeloma (126 at diagnosis and 40 after treatment) were stained with Congo red and studied by transmission and birefringence microscopy. Both focal and diffuse storages were considered positive. Overall, 67 patients were positive and 99 were negative to Congo red and apple-green birefringence. In particular, 51 of the 126 patients studied at diagnosis and 16 of the 40 patients with advanced disease were positive. Seventeen patients were r... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2971527 Thu, 05 Nov 2009 18:57:20 +0100 2971527 Splenic artery pseudoaneurysm with rupture by transformed splenic marginal zone B cell lymphoma http://www.medworm.com/index.php?rid=2965006&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgu44771521684472%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0851-2Authors Yu-Chung Huang, Taipei Veterans General Hospital Division of Hematology & Oncology, Department of Medicine No. 201, Sec. 2, Shipai Rd Taipei 112 TaiwanZhi-Yi Xie, Taipei Veterans General Hospital Division of Hematology & Oncology, Department of Medicine No. 201, Sec. 2, Shipai Rd Taipei 112 TaiwanHsiou-Shan Tseng, Taipei Veterans General Hospital Department of Radiology No. 201, Sec. 2, Shipai Rd Taipei 112 TaiwanChing-Feng Yang, Taipei Veterans General Hospital Department of Pathology No. 201, Sec. 2, Shipai Rd Taipei 112 TaiwanLiang-Tsai Hsiao, Taipei Veterans General Hospital Division of Hematology & Oncology, Department of Medicine No. 201, Sec. 2, Shipai Rd Taipei 112 Taiwan J... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2965006 Tue, 03 Nov 2009 21:11:50 +0100 2965006 Impact of critical care reconfiguration and track-and-trigger outreach team intervention on outcomes of haematology patients requiring intensive care admission http://www.medworm.com/index.php?rid=2947955&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5lp0870842817515%2F This study was done to assess outcomes and the impact of an early warning scoring system (EWS) and early involvement of ICU outreach teams. One hundred five haematology patients (haematopoietic stem cell transplant (HSCT) or non-HSCT) had 114 admissions to ICU between April 2006 and August 2008 which coincided with hospital-wide implementation of EWS. The survival to ICU discharge was 56 (53%). Thirty-three (33%) patients were alive at 6 months giving a 1-year survival of 31%. Of the 39 HSCT patients, nine were post-autologous and 30 post-allogeneic transplant. The survival to ICU discharge was 22 (56%) with 14 (36%) patients alive at 6 months. One year survival was 36%. Prior to the introduction of EWS and critical care outreach team (2004), survival to ICU discharge was 4... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2947955 Thu, 29 Oct 2009 19:38:16 +0100 2947955 Patients with del(5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression http://www.medworm.com/index.php?rid=2928857&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp28n8612n67x86q0%2F Abstract  Lenalidomide consistently induces transfusion independence and complete cytogenetic response in patients with myelodysplastic syndromes with 5q deletion. Only limited information on long-term outcome is currently available. We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of patients progressed into acute myeloid leukaemia. Most of them (87%) acquired chromosome aberrations in addition to the 5q deletion, i.e. underwent clonal evolution during leukaemogenesis. There were no clinical, cytological or cytogenetic marker... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2928857 Fri, 23 Oct 2009 18:52:52 +0100 2928857 Serum albumin level is a significant prognostic factor reflecting disease severity in symptomatic multiple myeloma http://www.medworm.com/index.php?rid=2917960&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8125p571g03451r3%2F Abstract  Serum albumin level, in association with serum interleukin-6 level, is a significant prognostic factor in multiple myeloma patients. The aim of this study was to determine any clinical factors associated with decreased serum albumin level. We retrospectively reviewed the records of 373 patients diagnosed with multiple myeloma at the Asan Medical Center, Seoul, Korea, between January 1996 and March 2008. Patients were divided into two groups according to serum albumin level (above or below 3.5 g/dL, the prognostic cutoff value), and clinical parameters were compared between groups. We aimed to identify any clinical parameters associated with low serum albumin levels. The group with serum albumin <3.5 g/dL showed older patient age, lower hemoglobin leve... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2917960 Wed, 21 Oct 2009 12:31:05 +0100 2917960 ABO discrepancy in a young Korean serviceman with common variable immunodeficiency http://www.medworm.com/index.php?rid=2917961&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy6m2t265tv267351%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0840-5Authors Seung Hwan Oh, Inje University Department of Laboratory Medicine, College of Medicine GaeGeum-dong, Busanjin-gu Busan 614-735 South KoreaCheol-In Kang, Sungkyunkwan University School of Medicine Division of Infectious Diseases, Samsung Medical Center 50 Ilwon-dong, Gangnam-gu Seoul 135-710 South KoreaJuwon Kim, Yonsei University College of Medicine Department of Laboratory Medicine 250 Seongsanno, Seodaemun-gu Seoul 120-752 South KoreaTae Sung Park, Kyung Hee University School of Medicine Department of Laboratory Medicine 1 Hoegi-dong, Dongdaemun-gu Seoul 130-702 South Korea Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2917961 Wed, 21 Oct 2009 12:31:04 +0100 2917961 Plasmablastic crisis of Philadelphia chromosome-positive chronic myeloid leukemia http://www.medworm.com/index.php?rid=2917962&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy86t115524811304%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0852-1Authors Kalliopi N. Manola, National Center for Scientific Research (NCSR) “Demokritos” Laboratory of Cytogenetics 15310 Aghia Paraskevi Athens GreeceDespina Pantelidou, Medical School AUTH First Department of Internal Medicine, Hematology department Thessaloniki GreeceMaria Papaioannou, Medical School AUTH First Department of Internal Medicine, Hematology department Thessaloniki Greece Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2917962 Wed, 21 Oct 2009 12:31:03 +0100 2917962 18F-FDG PET/CT in primary non-Hodgkin's lymphoma of the sinonasal tract http://www.medworm.com/index.php?rid=2917963&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F65767r6071463238%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0842-3Authors Adrian Tempescul, CHU Brest Department of Clinical Hematology, Institute of Cancerology and Hematology Avenue Foch 29609 Brest FranceSolene Querellou, CHU Brest Department of Nuclear Medicine Avenue Foch 29609 Brest FranceJean-Christophe Ianotto, CHU Brest Department of Clinical Hematology, Institute of Cancerology and Hematology Avenue Foch 29609 Brest FranceSylvie Boisramé, CHU Brest Department of Odontology Avenue Foch 29609 Brest FranceGerald Valette, CHU Brest Department of ORL Avenue Foch 29609 Brest FranceChristian Berthou, CHU Brest Department of Clinical Hematology, Institute of Cancerology and Hematology Avenue Foch 29609 Brest France Journal Annals of HematologyOnline ISSN 1... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2917963 Wed, 21 Oct 2009 09:05:07 +0100 2917963 Vitamin D deficiency and anemia: a cross-sectional study http://www.medworm.com/index.php?rid=2917964&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa4722230888951m1%2F This study demonstrates an association of vitamin D deficiency and a greater risk of anemia, lower mean hemoglobin, and higher usage of erythrocyte-stimulating agents. Future randomized studies are warranted to examine whether vitamin D directly affects erythropoiesis. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0850-3Authors John J. Sim, Kaiser Permanente Los Angeles Medical Center Division of Nephrology and Hypertension 4700 Sunset Blvd., 2nd Floor Nephrology Los Angeles CA 90027 USAPeter T. Lac, Kaiser Permanente Los Angeles Medical Center Division of Nephrology and Hypertension 4700 Sunset Blvd., 2nd Floor Nephrology Los Angeles CA 90027 USAIn Lu A. Liu, Kaiser Permanente Southern California Department of Research and Evaluation 100 S. Los Robles ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2917964 Tue, 20 Oct 2009 16:32:31 +0100 2917964 Glutathione S-transferase gene deletions and their effect on iron status in HbE/β thalassemia patients http://www.medworm.com/index.php?rid=2906436&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk623r33413q931w4%2F This study was aimed to compare the prevalence of GST deletions in 240 HbE/β thalassemia patients with 100 controls and to determine role of deletions on iron overload. We observed significantly higher frequency of GSTT1 (P = 0.001) and GSTT1/GSTM1 (P = 0.03) in comparison to controls. Patients who had null genotype for both the alleles, i.e., GSTT1/GSTM1 had significantly higher levels of serum iron (P = 0.007) and serum ferritin (P = 0.001) than patients with normal genotype for GST deletions. This is the first study to prove the role of GST gene deletions with iron overload in HbE/β thalassemia. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0847-yAuthors Vineeta Sharma, I.R.C.H. Building (first floor), All India Institute of M... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2906436 Fri, 16 Oct 2009 18:01:09 +0100 2906436 Relevance of target cell-induced apoptosis as mechanism of resistance against natural killer cells http://www.medworm.com/index.php?rid=2896486&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx06337x8344r0l83%2F Abstract  Natural killer (NK) cells contribute to the graft-versus-leukemia effect after allogeneic stem cell transplantation. However, the efficacy of NK cell-mediated tumor cell lysis is limited due to target cell resistance, and target cell-induced apoptosis (TiA) was proposed to contribute to differences in susceptibility to NK cells. Here we analyzed the effects of target cells on the apoptosis of cytokine-activated NK cells in vitro. We found no association of target cell susceptibility and TiA of NK cells in an array of human and murine target-effector cell combinations. Incubation of NK cells with caspase inhibitors blocked TiA incompletely, indicating that TiA is partly based on caspase-independent mechanisms. Modulating NK cell susceptibility against TiA by caspas... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2896486 Tue, 13 Oct 2009 08:15:30 +0100 2896486 Idiopathic neutropenia with fewer than 5% dysplasia may be a distinct entity of idiopathic cytopenia of undetermined significance http://www.medworm.com/index.php?rid=2896485&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx507718m231p7263%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0845-0Authors Keiko Ando, Tokyo Medical University The First Department of Internal Medicine (Hematology Division) 6-7-1 Nishishinjuku, Shinjuku-ku Tokyo 160-0023 JapanAtsushi Kodama, Tokyo Medical University Division of Cytogenetics, Central Laboratory Tokyo JapanTamiko Iwabuchi, Tokyo Medical University The First Department of Internal Medicine (Hematology Division) 6-7-1 Nishishinjuku, Shinjuku-ku Tokyo 160-0023 JapanJunko H. Ohyashiki, Tokyo Medical University Intractable Disease Research Center Tokyo JapanKazuma Ohyashiki, Tokyo Medical University The First Department of Internal Medicine (Hematology Division) 6-7-1 Nishishinjuku, Shinjuku-ku Tokyo 160-0023 Japan Journal Annals of HematologyOnli... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2896485 Tue, 13 Oct 2009 08:15:30 +0100 2896485 Subcutaneous anti-d globulin application is a safe treatment option of immune thrombocytopenia in children http://www.medworm.com/index.php?rid=2896484&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff147477rgn046276%2F Abstract  Subcutaneous (sc) administration of anti-d seems to offer the same efficacy as intravenous administration but with less side effects. Here we report our experience with sc anti-d for pediatric immune thrombocytopenia (ITP). A total of 12 children with a median age of 11.2 years had been treated by sc anti-d. They received a median of 2 sc anti-d applications (range 1–31) with a dosage of 250–375 IE/kg body weight. Only in one out of a total of 102 single applications, a minimal and self-limited side effect (chills) had been observed. The mean platelet count was almost doubled after sc anti-d (p < 0.0001). After a median follow-up of 11.4 months, all patients are alive without major bleeding and stay well. We conclude that sc anti-d is not o... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2896484 Tue, 13 Oct 2009 08:15:30 +0100 2896484 Postallogeneic hematopoietic stem cell transplantation relapse of acute myeloid leukemia presenting with salivary gland myelosarcoma http://www.medworm.com/index.php?rid=2880573&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc130087545r2466n%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0843-2Authors Yu-Hsuan Lai, Kaohsiung Medical University Hospital Division of Hematology-Oncology, Department of Internal Medicine Kaohsiung TaiwanChao-Sung Chang, Kaohsiung Medical University Hospital Division of Hematology-Oncology, Department of Internal Medicine Kaohsiung TaiwanYi-Chang Liu, Kaohsiung Medical University Hospital Division of Hematology-Oncology, Department of Internal Medicine Kaohsiung TaiwanTa-Chih Liu, Kaohsiung Medical University Hospital Division of Hematology-Oncology, Department of Internal Medicine Kaohsiung Taiwan Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2880573 Fri, 09 Oct 2009 06:06:23 +0100 2880573 Cell cycle and apoptosis regulatory gene expression in the bone marrow of patients with de novo myelodysplastic syndromes (MDS) http://www.medworm.com/index.php?rid=2877754&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm5q8153724684v32%2F In conclusion, our study showed altered expression of genes involved in apoptosis and cell cycle in MDS and increased expression of cyclin D1 in patients with CMML. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0835-2Authors Christina Economopoulou, Attikon University Hospital, 2nd Propedeutic Clinic of Internal Medicine 1 Rimini Str., Haidari Athens GreeceVassiliki Pappa, Attikon University Hospital, 2nd Propedeutic Clinic of Internal Medicine 1 Rimini Str., Haidari Athens GreeceSotiris Papageorgiou, Attikon University Hospital, 2nd Propedeutic Clinic of Internal Medicine 1 Rimini Str., Haidari Athens GreeceFrieda Kontsioti, Attikon University Hospital, 2nd Propedeutic Clinic of Internal Medicine 1 Rimini Str., Haidari Athens GreecePanagiota Economopoul... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2877754 Thu, 08 Oct 2009 07:14:21 +0100 2877754 An extensive analysis of the hereditary hemochromatosis gene HFE and neighboring histone genes: associations with childhood leukemia http://www.medworm.com/index.php?rid=2870258&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2038812l45m27462%2F Abstract  The most common mutation of the HFE gene C282Y has shown a risk association with childhood acute lymphoblastic leukemia (ALL) in Welsh and Scottish case–control studies. This finding has not been replicated outside Britain. Here, we present a thorough analysis of the HFE gene in a panel of HLA homozygous reference cell lines and in the original population sample from South Wales (117 childhood ALL cases and 414 newborn controls). The 21 of 24 variants analyzed were from the HFE gene region extending 52 kb from the histone gene HIST1H1C to HIST1H1T. We identified the single-nucleotide polymorphism (SNP) rs807212 as a tagging SNP for the most common HFE region haplotype, which contains wild-type alleles of all HFE variants examined. This intergenic SNP rs807212 y... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2870258 Tue, 06 Oct 2009 12:44:57 +0100 2870258 Deferasirox (Exjade®) significantly improves cardiac T2* in heavily iron-overloaded patients with β-thalassemia major http://www.medworm.com/index.php?rid=2864031&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc66654794662955j%2F This study monitored cardiac siderosis using T2* MRI in a cohort of 19 heavily iron-overloaded patients with β-thalassemia major receiving iron chelation therapy with deferasirox over an 18-month period. Overall, deferasirox therapy significantly improved mean ± standard deviation cardiac T2* from a baseline of 17.2 ± 10.8 to 21.5 ± 12.8 ms (+25.0%; P = 0.02). A concomitant reduction in median serum ferritin from a baseline of 5,497 to 4,235 ng/mL (−23.0%; P = 0.001), and mean liver iron concentration from 24.2 ± 9.0 to 17.6 ± 12.9 mg Fe/g dry weight (−27.1%; P = 0.01) was also seen. Improvements were seen in patients with various degrees of cardiac siderosis, including those patients with a baseline cardiac T2* of <10 m... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2864031 Thu, 01 Oct 2009 18:31:42 +0100 2864031 Hemophagocytosis associated with leukemia: a striking association with juvenile myelomonocytic leukemia http://www.medworm.com/index.php?rid=2864030&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl122861625nv75u6%2F Abstract  The aim of this study was to describe the characteristics and outcome in a group of pediatric patients with hematological malignancies who developed hemophagocytosis at diagnosis or during the disease course. Eight patients with hematological malignancy and associated hemophagocytosis were included. The initial diagnosis was juvenile myelomonocytic leukemia (JMML) in five, nonlymphoblastic leukemia (ANLL) in two, and T-cell lymphoma associated with myeloproliferative syndrome in one patient. Hemophagocytosis was concomitantly present at the time of diagnosis of the primary disease in four of the five patients with JMML and in the two patients with ANLL. Three had abnormalities related to chromosome 8 [(trisomy 8, monosomy 8, and t (8;13) (p11; p12)], and one had in... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2864030 Thu, 01 Oct 2009 18:31:42 +0100 2864030 Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate http://www.medworm.com/index.php?rid=2848585&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9x65h487115636l3%2F This study provides the first direct evidence that Beriplex® P/N can be rapidly infused for emergency coumarin therapy reversal without altering safety or effectiveness. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0830-7Authors Ingrid Pabinger, Medical University Vienna Department of Internal Medicine, Division of Haematology and Haemostaseology Vienna AustriaAndreas Tiede, Hannover Medical School Department of Haematology, Haemostasis, Oncology and Stem Cell Transplantation Hannover GermanyUwe Kalina, Hemophilia/Critical Care, CSL Behring GmbH Clinical Research & Development Marburg GermanySigurd Knaub, Hemophilia/Critical Care, CSL Behring GmbH Clinical Research & Development Marburg GermanyReinhard Germann, Academic Teaching Hospital Feldkirch Depa... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2848585 Tue, 29 Sep 2009 04:04:59 +0100 2848585 Reduction of serum free light chains predict renal recovery http://www.medworm.com/index.php?rid=2848586&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5352371527244xg3%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0836-1Authors Colin A. Hutchison, University Hospital Birmingham Renal Institute of Birmingham, Department of Nephrology Birmingham B152TH UK Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2848586 Mon, 28 Sep 2009 14:33:06 +0100 2848586 Levels of angiogenic factors in patients with multiple myeloma correlate with treatment response http://www.medworm.com/index.php?rid=2848587&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl6r57527l1j12771%2F Abstract  Angiogenesis plays a significant role in the pathogenesis of multiple myeloma (MM). We have measured concentrations of angiogenesis activators, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and hepatocyte growth factor (HGF), and inhibitors, including endostatin, thrombospondin-1 (TSP-1), and angiostatin in the peripheral and bone marrow blood of MM patients at diagnosis and after high-dose chemotherapy. We have analyzed 96 patients with secretory MM. Serial measurements of angiogenesis factors/inhibitors were analyzed in the plasma by subgroups based on the best treatment response. Concentrations of angiogenic factors were determined in the peripheral blood and bone marrow plasma. There were significant decreases of VEGF and... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2848587 Mon, 28 Sep 2009 14:32:46 +0100 2848587 Stomatocytosis heralding a case of acute Wilsonian crisis http://www.medworm.com/index.php?rid=2835142&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5447112t38632748%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0832-5Authors Amit R. Mehta, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School Department of Medicine New Brunswick NJ USAGratian Salaru, The Cancer Institute of New Jersey New Brunswick NJ USAJonathan S. Harrison, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School Department of Medicine New Brunswick NJ USA Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2835142 Thu, 24 Sep 2009 14:34:08 +0100 2835142 Fatal pneumocystis jiroveci pneumonia in ABVD-treated Hodgkin lymphoma patients http://www.medworm.com/index.php?rid=2810959&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn877x64848470008%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0833-4Authors Mats Kalin, Karolinska University Hospital Solna and Institutet Department of Medicine, Division of Infectious Diseases Stockholm SwedenSigurdur Yngvi Kristinsson, Karolinska University Hospital Solna Department of Medicine, Division of Hematology SE-171 76 Stockholm SwedenHonar Cherif, Karolinska University Hospital Solna Department of Medicine, Division of Hematology SE-171 76 Stockholm SwedenMarianne Lebbad, Swedish Institute for Infectious Disease Control Stockholm SwedenMagnus Björkholm, Karolinska University Hospital Solna Department of Medicine, Division of Hematology SE-171 76 Stockholm Sweden Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2810959 Fri, 18 Sep 2009 16:11:23 +0100 2810959 Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutical evaluation of patients with multiple myeloma http://www.medworm.com/index.php?rid=2810960&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx8274413441544w5%2F Abstract  Multiple myeloma is a malignant B-cell neoplasm that involves the skeleton in approximately 80% of the patients. With an average age of 60 years and a 5-years survival of nearly 45% Brenner et al. (Blood 111:2516–2520, 35) the onset is to be classified as occurring still early in life while the disease can be very aggressive and debilitating. In the last decades, several new imaging techniques were introduced. The aim of this review is to compare the different techniques such as radiographic survey, multidetector computed tomography (MDCT), whole-body magnetic resonance imaging (WB-MRI), fluorodeoxyglucose positron emission tomography- (FDG-PET) with or without computed tomography (CT), and 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy. We conclud... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2810960 Thu, 17 Sep 2009 23:35:18 +0100 2810960 Decreased hemolysis following administration of antioxidant—fermented papaya preparation (FPP) to a patient with PNH http://www.medworm.com/index.php?rid=2810961&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc671j729658xr5qw%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0821-8Authors Hussam Ghoti, Edit Wolfson Medical Center Department of Hematology Holon IsraelHanna Rosenbaum, Rambam Medical Center Department of Hematology and Bone Marrow Transplantation Haifa IsraelEitan Fibach, Hadassah–Hebrew University Medical Center Department of Hematology Jerusalem IsraelEliezer A. Rachmilewitz, Edit Wolfson Medical Center Department of Hematology Holon Israel Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2810961 Wed, 16 Sep 2009 12:27:33 +0100 2810961 Reversal of multidrug resistance by curcumin through FA/BRCA pathway in multiple myeloma cell line MOLP-2/R http://www.medworm.com/index.php?rid=2810962&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu7182p6460102194%2F In conclusion, curcumin reversed multidrug resistance of MOLP-2/R through inhibition of FA/BRCA pathway. The possible mechanisms include (1) reduction of DNA damage repair and stimulation of apoptosis of tumor cells through inhibition of FA/BRCA pathway, which is important for DNA repair, and (2) achievement of high concentration in target cells. Curcumin may be a safe reversal agent of multidrug resistance with low-dose DNA cross-linking agents. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0831-6Authors Hui Xiao, Zhongnan Hospital of Wuhan University Department of Hematology No.169 Donghu Road Wuhan 430071 ChinaQi Xiao, Yanqiao Hospital of Yunyang Medical College Department of Internal Medicine Shiyan 442000 ChinaKejian Zhang, Zhongnan Hospital of W... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2810962 Wed, 16 Sep 2009 12:27:32 +0100 2810962 Results of FLT3 mutation screening and correlations with immunophenotyping in 169 Brazilian patients with acute myeloid leukemia http://www.medworm.com/index.php?rid=2767414&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9144w37447211428%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0817-4Authors Antonio R. Lucena-Araujo, University of São Paulo Hematology Division, Department of Internal Medicine, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirão Preto Ribeirão Preto BrazilDanielle L. Souza, University of São Paulo Hematology Division, Department of Internal Medicine, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirão Preto Ribeirão Preto BrazilFabio Morato de Oliveira, University of São Paulo Hematology Division, Department of Internal Medicine, National Institute of Science and Technology on Cell Based Therapy, Medical School of Ribeirão Preto Ribeirão Preto BrazilMariana Tereza Lira Be... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2767414 Thu, 03 Sep 2009 06:23:52 +0100 2767414 Long-term response to deferiprone therapy in Asian Indians http://www.medworm.com/index.php?rid=2767413&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F93445l285170j3l4%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s00277-009-0825-4Authors Inusha Panigrahi, Post-Graduate Institute of Medical Education & Research (PGIMER) Hemato-Oncology & Genetics Units, Department of Pediatrics, Advanced Pediatrics Centre (APC) Chandigarh IndiaRam K. Marwaha, Post-Graduate Institute of Medical Education & Research (PGIMER) Hemato-Oncology & Genetics Units, Department of Pediatrics, Advanced Pediatrics Centre (APC) Chandigarh IndiaRashmi R. Das, Post-Graduate Institute of Medical Education & Research (PGIMER) Hemato-Oncology & Genetics Units, Department of Pediatrics, Advanced Pediatrics Centre (APC) Chandigarh India Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2767413 Thu, 03 Sep 2009 06:23:52 +0100 2767413 Compound heterozygosity of Hb Hamilton and de novo mutated HbM Saskatoon http://www.medworm.com/index.php?rid=2767416&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F81207528183l6860%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0828-1Authors Saskia Brunner-Agten, Kantonsspital Aarau Zentrum für Labormedizin 5001 Aarau SwitzerlandMartin Hergersberg, Kantonsspital Aarau Zentrum für Labormedizin 5001 Aarau SwitzerlandRoberto Herklotz, Kantonsspital Aarau Zentrum für Labormedizin 5001 Aarau SwitzerlandAndreas Hirt, Inselspital Bern Kinderpoliklinik 3010 Bern SwitzerlandAndreas R. Huber, Kantonsspital Aarau Zentrum für Labormedizin 5001 Aarau Switzerland Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2767416 Thu, 03 Sep 2009 06:23:49 +0100 2767416 Compound heterozygosity for HbD Punjab and polyadenylation signal mutation causes clinically asymptomatic mild hypochromia and microcytosis http://www.medworm.com/index.php?rid=2767415&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq7723837j228v2g5%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0827-2Authors Katta Mohan Girisha, Kasturba Medical College Genetics Clinic, Department of Pediatrics Manipal 576104 IndiaSaadi Abdul Vahab, Manipal University Manipal Life Sciences Center Manipal 576104 IndiaAshwin B. Dalal, Center for DNA Fingerprinting and Diagnostics Hyderabad IndiaP. M. Gopinath, Manipal University Manipal Life Sciences Center Manipal 576104 IndiaK. Satyamoorthy, Manipal University Manipal Life Sciences Center Manipal 576104 India Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2767415 Thu, 03 Sep 2009 06:23:49 +0100 2767415 Expression analysis of proteins involved in the non homologous end joining DNA repair mechanism, in the bone marrow of adult de novo myelodysplastic syndromes http://www.medworm.com/index.php?rid=2767418&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff3034140g2731756%2F Abstract  Myelodysplastic syndromes (MDS) are characterized by genetic instability which is associated with abnormal DNA repair mechanisms. The most lethal type of DNA damage are double strand DNA breaks (DSBs), which are mainly repaired by Non Homologous End Joining Mechanism (NHEJ), whose core enzyme components include the Ku70/Ku80 heterodimer, DNA–PKcs, XRCC4 and DNA Ligase IV. The aim of the present study was the analysis of expression of proteins required for NHEJ in bone marrow cells of adult de novo MDS and their association with clinical characteristics and prognosis. Our analysis included 48 cases of MDS; 19 RA, 5 RARS, 19 RAEB, 3 RAEB-T, 1 CMML, 1 transformation to AML according to FAB classification. The expression of the enzymes Ku70, Ku80, XRCC4, DNA-PKcs an... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2767418 Thu, 03 Sep 2009 06:23:47 +0100 2767418 DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance http://www.medworm.com/index.php?rid=2767417&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp11p8437p3267671%2F Abstract  Aberrant DNA methylation is considered an important epigenetic mechanism for gene inactivation. Monoclonal gammopathy of undetermined significance (MGUS) is believed to be a precursor of multiple myeloma (MM). We have analyzed methylation status of p15 INK4B , p16 INK4A , ARF, SOCS-1, p27 KIP1 , RASSF1A, and TP73 genes in bone marrow DNA samples from 21 MGUS and 44 MM patients, in order to determine the role of aberrant promoter methylation as one of the steps involved in the progression of MGUS to MM. Methylation specific polymerase chain reaction assay followed by DNA sequencing of the resulting product was performed. SOCS-1 gene methylation was significantly more frequent in MM (52%) than in MGUS (14%; p = 0,006). Methylation frequencies of TP73, A... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2767417 Thu, 03 Sep 2009 06:23:47 +0100 2767417 Acute lymphoblastic leukemia masquerading as juvenile rheumatoid arthritis: diagnostic pitfall and association with survival http://www.medworm.com/index.php?rid=2767420&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6433jq1506148148%2F This study was designed to identify ALL patients with initial diagnosis of JRA, compare their clinicolaboratory characteristics and outcome with other ALL patients treated at our center. Case records of 762 patients with ALL were analyzed. Information regarding the clinical-demographic profile, therapy and outcome were recorded. Of the children, 49 (6.4%) had initial presentation mimicking JRA. Asymmetric oligoarthritis was the most common pattern of joint involvement. Majority presented with fever, pallor, arthritis, night pain, and bone pain. None of the routine prognostic factors including age, gender, lymphadenopathy, hepatosplenomegaly, total leukocytes count (TLC), and platelet count were significantly associated with relapse/death. The mean symptom-presentation interval (SPI),... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2767420 Thu, 03 Sep 2009 06:23:46 +0100 2767420 Progressive multifocal leukoencephalopathy: a report of three cases in HIV-negative patients with non-Hodgkin's lymphomas treated with rituximab http://www.medworm.com/index.php?rid=2767419&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn87wu85217142n55%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0819-2Authors Marco Tuccori, University of Pisa Division of Pharmacology and Chemotherapy, Department of Internal Medicine Via Roma 55 56126 Pisa ItalyDaniele Focosi, University of Pisa Division of Haematology, Department of Oncology, Transplantations and New Technologies in Medicine Pisa ItalyFabrizio Maggi, University of Pisa Virology Section and Retrovirus Centre, Department of Experimental Pathology Pisa ItalyMirco Cosottini, University of Pisa Department of Neuroscience Pisa ItalyBarbara Meini, Tuscan Regional Centre for Pharmacovigilance Florence ItalyFabio Lena, Tuscan Regional Centre for Pharmacovigilance Florence ItalyCorrado Blandizzi, University of Pisa Division of Pharmacology and Chemotherapy, ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2767419 Thu, 03 Sep 2009 06:23:46 +0100 2767419 Rituximab retherapy in patients with relapsed aggressive B cell and mantle cell lymphoma http://www.medworm.com/index.php?rid=2767421&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr12m72w27215j825%2F We report here a single-centre retrospective outcome analysis of second-line immunochemotherapy with rituximab. In 28 patients with relapsed or refractory diffuse large B cell lymphomas, first-line immunochemotherapy had induced objective responses in 18 patients. Nine of 28 patients responded to rituximab containing salvage therapy, leading to a median overall survival of 243 days after start of second immunochemotherapy. Long-term disease free survivors (1,260 and 949 days) were restricted to the group of twelve patients that had received allogeneic stem cell transplantation as consolidation therapy. In 21 patients with relapsed mantle cell lymphomas (MCL), 19 patients had reached remissions with first-line therapy. Of those, 16 patients experienced responses to salvage t... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2767421 Tue, 01 Sep 2009 16:47:51 +0100 2767421 Reduction of 5-azacitidine induced skin reactions in MDS patients with evening primrose oil http://www.medworm.com/index.php?rid=2745012&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbh7x580uw3831463%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0824-5Authors Uwe Platzbecker, Universitätsklinikum “Carl Gustav Carus” Dresden Medizinische Klinik und Poliklinik I 01307 Dresden GermanyCarlo Aul, St. Johannes Hospital Duisburg Duisburg GermanyGerhard Ehninger, Universitätsklinikum “Carl Gustav Carus” Dresden Medizinische Klinik und Poliklinik I 01307 Dresden GermanyAristoteles Giagounidis, St. Johannes Hospital Duisburg Duisburg Germany Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2745012 Fri, 28 Aug 2009 16:57:52 +0100 2745012 Response to Imatinib mesylate in chronic myeloid leukemia patients with variant BCR-ABL fusion transcripts http://www.medworm.com/index.php?rid=2745013&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh707348u01773572%2F Abstract  Chronic myeloid leukemia patients with different BCR-ABL transcripts might respond differently to Imatinib mesylate. This prompted us to study BCR-ABL transcripts in chronic myeloid leukemia (CML) patients and their correlation with response to Imatinib. Eighty-seven chronic phase CML patients (median age, 35 years; range, 13–62 years; M/F, 59:28) were included in this study; 57 patients had received interferon-α and/or hydroxyurea, and 30 were previously untreated. All patients received Imatinib mesylate (Gleevec) 400 mg daily. Complete hematological remission rate and major cytogenetic response (CGR) rates were 99% and 72%, respectively. B3a2 transcript was present in 53% of patients, b2a2 in 39%, and both transcripts in 8% of patients. Twenty ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2745013 Fri, 28 Aug 2009 16:57:49 +0100 2745013 Frequencies of non-Hodgkin’s lymphoma subtypes in Kuwait: comparisons between different ethnic groups http://www.medworm.com/index.php?rid=2742732&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2pvx882010368r2v%2F Abstract  There is a wide variation in the prevalence of various subtypes of non-Hodgkin’s lymphoma worldwide. The aim of this study was to determine the relative frequency of different subtypes of non-Hodgkin’s lymphoma in Kuwait based on the Revised European–American Lymphoma (REAL) classification. From 1998 to 2006, 738 subjects were included that were registered with non-Hodgkin’s lymphoma in the population-based cancer registry at the Kuwait Cancer Control Center. Expert pathologists reviewed histological slides from all subjects. We performed detailed immunohistochemical studies and classified subjects based on the REAL classification. The prevalence of different types of non-Hodgkin's lymphoma was determined based on age, sex, site of disease, and ethnicity. ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2742732 Thu, 27 Aug 2009 16:33:11 +0100 2742732 Low incidence of clinically apparent thromboembolism in Korean patients with multiple myeloma treated with thalidomide http://www.medworm.com/index.php?rid=2731976&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk283765370nwl878%2F Abstract  The frequency of thromboembolic events (TE) in Caucasian patients with multiple myeloma (MM) receiving thalidomide as the initial treatment has been reported to be 10~58% without prophylactic anticoagulation. Korean MM patients treated with thalidomide were studied to determine the frequency of TE and associated risk factors. A retrospective medical record review of the Korean MM registry from 25 centers in Korea between 2003 and 2007 was performed. We assessed the incidence of arterial and venous TE and the associated clinical parameters. Three hundred and sixty MM patients (median age 61 years, range 32–88 years) received thalidomide treatment. Fourteen patients (3.9%) developed TE: 12 had venous and two had arterial locations. The sites for the veno... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2731976 Mon, 24 Aug 2009 16:51:32 +0100 2731976 Subcutaneous alemtuzumab plus cyclosporine for the treatment of aplastic anemia http://www.medworm.com/index.php?rid=2731975&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F401h260142k22361%2F Abstract  Aplastic anemia (AA) is most frequently due to autoimmune attack on its own stem cells. Alemtuzumab is a monoclonal antibody which recognizes the CD52 antigen on the surface of T and B cells. It has proved useful in autoimmune diseases, lymphoproliferative conditions, and graft versus host disease. Based on its immunosuppressive properties, we treated 14 AA patients with alemtuzumab. Median age was 23 years. Ten milligrams of alemtuzumab were injected subcutaneously each day for five consecutive days. Cyclosporine A was also administered orally at a dose of 2 mg/kg every 12 h for 3 months, and then gradually tapered. Response to alemtuzumab was followed for a median of 20 months. There were eight responses (57.1%), two complete and six part... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2731975 Mon, 24 Aug 2009 16:51:32 +0100 2731975 Treatment of 5q-syndrome with lenalidomide in an HIV-positive patient under cART http://www.medworm.com/index.php?rid=2731977&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft7636666k86j3613%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0815-6Authors Sabine Blum, Centre Hospitalier Universitaire Vaudois Service of Haematology Rue du Bugnon 46 1011 Lausanne SwitzerlandMatthias Cavassini, Centre Hospitalier Universitaire Vaudois Department of Infectious Diseases Rue du Bugnon 46 1011 Lausanne SwitzerlandJean-François Lambert, Centre Hospitalier Universitaire Vaudois Service of Haematology Rue du Bugnon 46 1011 Lausanne SwitzerlandAurélie Fayet, Centre Hospitalier Universitaire Vaudois Division of Clinical Pharmacology Rue du Bugnon 46 1011 Lausanne SwitzerlandMarc Schapira, Centre Hospitalier Universitaire Vaudois Service of Haematology Rue du Bugnon 46 1011 Lausanne SwitzerlandMartine Jotterand, Centre Hospitalier Universitaire Vaudois Un... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2731977 Mon, 24 Aug 2009 16:51:31 +0100 2731977 Reactivation of hepatitis B virus following rituximab-based regimens: a serious complication in both HBsAg-positive and HBsAg-negative patients http://www.medworm.com/index.php?rid=2723695&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F30g414932781934t%2F In conclusion, rituximab-based therapy may cause serious HBV-related complications and even death in both HBsAg-positive and HBsAg-negative patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0806-7Authors Sung-Nan Pei, Chang Gung University College of Medicine Division of Hema-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital–Kaohsiung Medical Center Kaohsiung TaiwanChien-Hung Chen, Chang Gung University College of Medicine Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital–Kaohsiung Medical Center Kaohsiung TaiwanChuan-Mo Lee, Chang Gung University College of Medicine Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital–Kaohsiung ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2723695 Fri, 21 Aug 2009 15:26:45 +0100 2723695 A novel t(1;12)(q21;q24) in a patient with myelodysplastic syndrome http://www.medworm.com/index.php?rid=2723694&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb168k37405034262%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0814-7Authors Tae Sung Park, Kyung Hee University School of Medicine Department of Laboratory Medicine 1 Hoegi-dong, Dongdaemun-gu Seoul 130-702 KoreaSang-Guk Lee, Yonsei University College of Medicine Department of Laboratory Medicine 250 Seongsanno, Seodaemun-gu Seoul 120-752 KoreaJaewoo Song, Yonsei University College of Medicine Department of Laboratory Medicine 250 Seongsanno, Seodaemun-gu Seoul 120-752 KoreaJin Seok Kim, Yonsei University College of Medicine Department of Internal Medicine 250 Seongsanno, Seodaemun-gu Seoul 120-752 KoreaJong Rak Choi, Yonsei University College of Medicine Department of Laboratory Medicine 250 Seongsanno, Seodaemun-gu Seoul 120-752 Korea Journal Annals of Hemato... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2723694 Fri, 21 Aug 2009 15:26:45 +0100 2723694 Sheehan’s syndrome with pancytopenia—complete recovery after hormone replacement (case series with review) http://www.medworm.com/index.php?rid=2723696&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa7167585x74q3532%2F Abstract  Reports of pancytopenia in patients with Sheehan’s syndrome are rare, because the disorder is not commonly seen in western countries. A case series of pancytopenia in three patients of Sheehan’s syndrome is presented. Three women aged 22, 30, and 34 years developed Sheehan’s syndrome preceded by post partum hemorrhage. During investigations, they were found to have pancytopenia with hypocellular marrow. Treatment with thyroxine and glucocorticoids resulted in complete recovery after attaining euthyroid and eucortisolemic state. Review of literature revealed the rarity of the disorder, with only four cases reported so far. Multiple anterior pituitary hormone deficiencies in Sheehan’s syndrome are responsible for pancytopenia; replacement of thyroid and... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2723696 Fri, 21 Aug 2009 15:26:43 +0100 2723696 Peripheral blood stem cell collection in elderly patients http://www.medworm.com/index.php?rid=2721754&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx2030h0g23344rt4%2F Abstract  Intensive treatments like autologous blood stem cell transplantations are standard consolidation treatments for lymphoma and myeloma in young people. The upper age limit for these procedures is constantly increasing. Instead of studying the impact of aging on harvesting peripheral blood stem cells (PBSC), we performed a retrospective study to explore the feasibility of collecting stem cells from patients older than 65 years and compared the efficacy to harvest in younger patients. During a period of 7 years, we identified 108 patients with myeloma or lymphoma who were older than 65 years who underwent PBSC collection. Only eight patients failed to produce a successful harvest. The majority of patients only needed one apheresis (71%). There was a med... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2721754 Thu, 20 Aug 2009 08:29:14 +0100 2721754 Toxic epidermal necrolysis following thalidomide and dexamethasone treatment for multiple myeloma: a case report http://www.medworm.com/index.php?rid=2721755&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F67rh5k1550277krx%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0810-yAuthors Wan Kyu Eo, Kyung Hee University, East-West Neo Medical Center Integrative Cancer Center Seoul South KoreaSe Hyun Kim, Kyung Hee University Graduate School of East-West Medical Science Yongin South KoreaSeong Ha Cheon, Kyung Hee University, East-West Neo Medical Center Integrative Cancer Center Seoul South KoreaSang Hun Lee, Kyung Hee University, East-West Neo Medical Center Integrative Cancer Center Seoul South KoreaJong Soo Jeong, Kyung Hee University, East-West Neo Medical Center Integrative Cancer Center Seoul South KoreaYang Soo Kim, Kosin University College of Medicine Department of Internal Medicine Busan South KoreaHee Kyung Chang, Kosin University College of Medicine Department of Pat... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2721755 Thu, 20 Aug 2009 08:29:13 +0100 2721755 Dose-dense therapy improves survival in aggressive non-Hodgkin’s lymphoma http://www.medworm.com/index.php?rid=2721756&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm52k857u64t15078%2F This study aimed to determine whether dose-dense therapy improves 3-year survival over the standard therapy for untreated aggressive lymphoma. One hundred and fifteen patients with untreated aggressive lymphoma were stratified by center, age, and international prognostic index and randomized to one of two treatment arms. One hundred and three were eligible. The experimental dose-dense arm consisted of weekly therapy with cyclophosphamide, epirubicine, vincristine, prednisolone, ifosfamide, etoposide, methotrexate, dexamethasone, and filgrastim (CEOP/IMVP-Dexa). The standard arm consisted of three-weekly cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). The primary endpoint was overall survival after 3 years. Overall survival at 3 years was 0.766 (95% CI 0... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2721756 Thu, 20 Aug 2009 08:29:11 +0100 2721756 Post-autologous stem cell transplantation administration of rituximab improves the outcome of patients with aggressive B cell non-Hodgkin’s lymphoma http://www.medworm.com/index.php?rid=2717803&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft63471185n506058%2F We describe our experience with the administration of rituximab post-ASCT, either as maintenance therapy or for the treatment of relapsed disease in patients with aggressive B cell NHL. Fifty-six patients achieved complete remission post-transplant, and 19 of them received maintenance with rituximab. Maintenance with rituximab resulted in statistically significant superior outcome in terms of progression free (PFS; p = 0.002) and overall survival (OS; p = 0.011). The median PFS and OS of patients in the maintenance arm has not been reached yet, while the median PFS and OS of patients in the control arm were 29 and 42 months, respectively. Fifty-four patients had disease progression or relapsed post-ASCT, and 15 of them received rituximab in combination with chemo- and/or ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2717803 Wed, 19 Aug 2009 18:01:53 +0100 2717803 Reversal of dialysis-dependent renal failure in patients with advanced multiple myeloma: single institutional experiences over 8 years http://www.medworm.com/index.php?rid=2717804&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa774532n272r3jq6%2F Abstract  Acute renal failure in patients with multiple myeloma (MM) requiring dialysis is a serious complication and is associated with extremely poor survival. In addition, its treatment included high-dose dexamethasone and/or thalidomide-containing regimens on the reversibility of renal function, which has not been adequately evaluated previously. We studied the impact on the reversibility of high-dose dexamethasone and/or thalidomide-containing regimen in 12 newly diagnosed MM patients (median 74 years, range; 63–85 years) who required dialysis at Kameda General Hospital from 2001 to 2008. There were seven light chain only myelomas, three IgD myelomas, and two IgG myelomas. Ten patients initially received high-dose dexamethasone-based treatment and two recei... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2717804 Wed, 19 Aug 2009 18:01:49 +0100 2717804 Iron overload and chelation therapy in patients with low-risk myelodysplastic syndromes with transfusion requirements http://www.medworm.com/index.php?rid=2717805&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff545m44565665657%2F In conclusion, most low-risk transfusion-dependent MDS patients develop IO, but only a minority receives a minimally effective and timely iron chelation therapy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0794-7Authors Angel F. Remacha, Centro Hospitalario de Toledo Hematology Department Avenida Barber, 30. 45004 Toledo SpainBeatriz Arrizabalaga, Hospital de Cruces Barakaldo SpainConsuelo Del Cañizo, Hospital Universitario de Salamanca Salamanca SpainGuillermo Sanz, Hospital La Fe Valencia SpainAna Villegas, Hospital Clínico San Carlos Madrid Spain Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2717805 Wed, 19 Aug 2009 08:26:21 +0100 2717805 Unusual presentation of multiple pathologic bone fractures in a patient with gastric mucosa-associated lymphoid tissue lymphoma http://www.medworm.com/index.php?rid=2714077&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F94k2530v401h2vk3%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0809-4Authors Sung-Hsin Kuo, National Taiwan University Hospital and National Taiwan University College of Medicine Department of Oncology Taipei TaiwanRuoh-Fang Yen, National Taiwan University Hospital and National Taiwan University College of Medicine Department of Nuclear Medicine Taipei TaiwanChung-Wu Lin, National Taiwan University Hospital and National Taiwan University College of Medicine Department of Pathology Taipei TaiwanLi-Tzong Chen, National Health Research Institutes Institute of Cancer Research Taipei TaiwanHwei-Fang Tien, National Taiwan University Hospital and National Taiwan University College of Medicine Department of Internal Medicine Taipei TaiwanAnn-Lii Cheng, National Taiwan Universi... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2714077 Mon, 17 Aug 2009 19:07:21 +0100 2714077 Treatment of multiple myeloma and arterial thrombosis http://www.medworm.com/index.php?rid=2714078&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq23q67n121061611%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0803-xAuthors Wouter Raven, Maasstad Hospital Department of Internal Medicine Rotterdam The NetherlandsArie Berghout, Maasstad Hospital Department of Internal Medicine Rotterdam The NetherlandsAnja van Houten, Maasstad Hospital Department of Internal Medicine Rotterdam The NetherlandsFrank W. G. Leebeek, Erasmus University Medical Center Department of Hematology Rotterdam The Netherlands Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2714078 Mon, 17 Aug 2009 19:07:19 +0100 2714078 A rare case of extranasal NK/T cell lymphoma presenting as autoimmune rheumatic manifestations associated with Sjögren's syndrome http://www.medworm.com/index.php?rid=2710531&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F852v42154n044248%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0805-8Authors Bing Yan, West China Hospital of Sichuan University Department of Rheumatology No. 37, Guoxue Alley Chengdu Sichuan Province 610041 ChinaYi Liu, West China Hospital of Sichuan University Department of Rheumatology No. 37, Guoxue Alley Chengdu Sichuan Province 610041 ChinaDan Hu, West China Hospital of Sichuan University Department of Rheumatology No. 37, Guoxue Alley Chengdu Sichuan Province 610041 ChinaGandi Li, West China Hospital of Sichuan University Department of Pathology Chengdu Sichuan Province 610041 China Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2710531 Sun, 16 Aug 2009 19:23:26 +0100 2710531 Successful treatment of MDS with lenalidomide, complicated by transient autoimmune hemolysis http://www.medworm.com/index.php?rid=2697533&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxk372808wl5j0738%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0802-yAuthors Wan-Ling Sun, Xuanwu Hospital Capital Medical University Department of Hematology Beijing ChinaLeonhard Köck, County Hospital of Lienz Department of Internal Medicine Lienz AustriaAlois Walder, County Hospital of Lienz Department of Internal Medicine Lienz AustriaMartin Erdel, Medical University of Innsbruck Department of Human Genetics/Cytogenetics Innsbruck AustriaSusanne Kilga-Nogler, Central Hospital of Innsbruck Institute of Transfusion Medicine Innsbruck AustriaHarald Schennach, Central Hospital of Innsbruck Institute of Transfusion Medicine Innsbruck AustriaMichael Fiegl, Medical University of Innsbruck Department of Internal Medicine V, Division of Hematology and Oncology Anichstrasse... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2697533 Tue, 11 Aug 2009 16:53:53 +0100 2697533 The prognostic value of immunohistochemical subtyping in Chinese patients with de novo diffuse large B-cell lymphoma undergoing CHOP or R-CHOP treatment http://www.medworm.com/index.php?rid=2697534&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F249l628651242528%2F The objective of this study was to evaluate the prognostic value of immunohistochemical subtyping and the International Prognostic Index (IPI) for predicting treatment outcome in Chinese DLBCL patients. We followed 108 cases of DLBCL and performed prognostic analyses based on molecular subtyping of the disease through immunostaining of tissue samples. The use of rituximab conferred a clinical benefit to DLBCL patients regardless of disease subtype. Importantly, this treatment regimen also improved outcomes in patients with the non-germinal centre B-cell-like (GCB) DLBCL subtype, frequently associated with poorer prognosis. Our results suggest that IPI was the best tool for the prediction of treatment outcome in our patient cohort, regardless of treatment regimen. Furthermore, the use... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2697534 Tue, 11 Aug 2009 00:00:30 +0100 2697534 A novel β-globin gene deletion (codons 89–93) in a Chinese family http://www.medworm.com/index.php?rid=2680030&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F32g585g10815q61r%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0798-3Authors Dong-Zhi Li, Guangzhou Maternal and Neonatal Hospital Prenatal Diagnostic Center Renminzhong Road 402 Guangzhou Guangdong 510180 ChinaCan Liao, Guangzhou Maternal and Neonatal Hospital Prenatal Diagnostic Center Renminzhong Road 402 Guangzhou Guangdong 510180 ChinaJian Li, Guangzhou Maternal and Neonatal Hospital Prenatal Diagnostic Center Renminzhong Road 402 Guangzhou Guangdong 510180 ChinaRu Li, Guangzhou Maternal and Neonatal Hospital Prenatal Diagnostic Center Renminzhong Road 402 Guangzhou Guangdong 510180 China Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2680030 Tue, 04 Aug 2009 21:15:47 +0100 2680030 Long-term response to deferiprone therapy in Asian Indians http://www.medworm.com/index.php?rid=2680031&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F352753623v04j153%2F Abstract  Deferiprone (L1) has been used in several countries for iron chelation therapy for over one decade. Long-term results on the drug are lacking. In the present study, data of 110 patients on deferiprone (L1) for up to 17 years were analyzed. On a mean L1 dose of 70.2 mg/kg/day (range 44–100), serum ferritin level showed a very steady decrease with time from an initial mean (±SD) of 3,033.61 ± 1,468.04 ng/ml to final of 1,665.08 ± 949.93 ng/ml after a mean (±SD) of 6.1 ± 3.8 years. In total, 13 patients discontinued L1 therapy. Major complications of L1 requiring permanent discontinuation of treatment included arthropathy (n = 8, 7.2%) and neutropenia/agranulocytosis (n = 5, 4.5%). Lesser complications permitting con... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2680031 Tue, 04 Aug 2009 21:15:46 +0100 2680031 Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura http://www.medworm.com/index.php?rid=2661629&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F52w63t307749k37q%2F Abstract  To investigate the role of Notch signaling pathway in immune thrombocytopenic purpura (ITP), we measured the expression of 11 Notch pathway molecules in ITP patients and evaluated their clinical relevance. Real-time reverse transcriptase polymerase chain reaction results showed there was aberrant expression of some Notch molecules in ITP. Notch1 and Notch3 expression elevated, while Notch2 decreased statistically in ITP patients. As for Notch ligands, only DLL1 was found downregulated in ITP. The expression of Notch target gene, Hes1, was also upregulated. In accordance with the mRNA level, Notch1 and Hes1 protein expression was also found elevated by Western blot. Immunocytochemistry showed that Notch1 expressed highly in the cytomembrane, cytoplasm, and part of ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2661629 Thu, 30 Jul 2009 19:53:18 +0100 2661629 Efficacy of bortezomib in refractory form of multicentric Castleman disease associated to poems syndrome (MCD-POEMS variant) http://www.medworm.com/index.php?rid=2651670&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwm418q416576041v%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0795-6Authors Marta Anna Sobas, Hospital Clinico Universitario de Santiago de Compostela Servicio de Hematologia y Hemoterapia c/Choupana s/n 15-706 Santiago de Compostela SpainNatalia Alonso Vence, Hospital Clinico Universitario de Santiago de Compostela Servicio de Hematologia y Hemoterapia c/Choupana s/n 15-706 Santiago de Compostela SpainJose Diaz Arias, Hospital Clinico Universitario de Santiago de Compostela Servicio de Hematologia y Hemoterapia c/Choupana s/n 15-706 Santiago de Compostela SpainAngeles Bendaña Lopez, Hospital Clinico Universitario de Santiago de Compostela Servicio de Hematologia y Hemoterapia c/Choupana s/n 15-706 Santiago de Compostela SpainMaximo Fraga Rodriguez, Hospital Clinico ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2651670 Mon, 27 Jul 2009 21:44:06 +0100 2651670 Nonpegylated liposomal doxorubicin is highly active in patients with B and T/NK cell lymphomas with cardiac comorbidity or higher age http://www.medworm.com/index.php?rid=2651671&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm851226x71q8314j%2F Abstract  We used nonpegylated liposomal doxorubicin (NPLD) in cytostatic drug combinations to treat 37 patients with non-Hodgkin's lymphoma and pre-existing cardiac disorder or elderly patients with reduced physical state who were ineligible for conventional anthracycline-containing therapy. High remission rates were observed in this poor-risk population: Complete remission rates were 75% for diffuse large B cell lymphoma (DLBCL) and 55% for T/NK cell neoplasm (overall response rate of 80% and 89%, respectively). Twenty-seven patients (73%) are still alive after a median observation time of 14 months. No major cardiac or gastrointestinal toxicity was observed. Extravasation of NPLD in two patients resulted in mild inflammation without tissue damage. Hematologic toxici... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2651671 Mon, 27 Jul 2009 21:44:01 +0100 2651671 Occult Hodgkin lymphoma presenting as polymyalgia rheumatica: value of [(18)F]-FDG positron emission tomography http://www.medworm.com/index.php?rid=2642920&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa2635g0g31767161%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0779-6Authors C. Durant, CHU Hotel Dieu Service de Médecine Interne 1, place Alexis Ricordeau 44093 Nantes Cedex FranceB. Hervier, CHU Hotel Dieu Service de Médecine Interne 1, place Alexis Ricordeau 44093 Nantes Cedex FranceC. Ansquer, CHU Hotel Dieu Nuclear Medicine Nantes FranceA. Masseau, CHU Hotel Dieu Service de Médecine Interne 1, place Alexis Ricordeau 44093 Nantes Cedex FranceM. Hamidou, CHU Hotel Dieu Service de Médecine Interne 1, place Alexis Ricordeau 44093 Nantes Cedex France Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2642920 Sat, 25 Jul 2009 14:46:10 +0100 2642920 A phase II multiple dose clinical trial of histone deacetylase inhibitor ITF2357 in patients with relapsed or progressive multiple myeloma http://www.medworm.com/index.php?rid=2642921&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqx75172vv107373j%2F In conclusion, when given at a dose of 100 mg twice daily alone or combined with dexamethasone, ITF2357 proved tolerable but showed a modest clinical benefit in advanced MM. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0793-8Authors Monica Galli, Ospedali Riuniti Div. of Hematology Largo Barozzi, 1 24128 Bergamo ItalySilvia Salmoiraghi, Ospedali Riuniti Div. of Hematology Largo Barozzi, 1 24128 Bergamo ItalyJoseé Golay, Ospedali Riuniti Div. of Hematology Largo Barozzi, 1 24128 Bergamo ItalyAntonella Gozzini, Azienda Ospedaliera Universitaria Careggi Firenze ItalyClaudia Crippa, Spedali Civili Div. of Hematology Brescia ItalyNorbert Pescosta, Ospedale S. Maurizio Div. of Hematology Bolzano ItalyAlessandro Rambaldi, Ospedali Riuniti Div. of Hematol... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2642921 Sat, 25 Jul 2009 14:46:06 +0100 2642921 The use of desmopressin in congenital factor XI deficiency: a systematic review http://www.medworm.com/index.php?rid=2623466&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F256l3705g7231610%2F Abstract  Factor XI (FXI) deficiency is a rare inherited coagulation disorder characterized by infrequent spontaneous bleeding, but increased risk of hemorrhagic complications especially after trauma or surgery. Treatment options for FXI-deficient patients include virus-inactivated fresh frozen plasma, plasma-derived FXI concentrates, and activated recombinant FVII. Inhibitors of fibrinolysis, such as tranexamic acid, and desmopressin (DDAVP) have also been used in these patients, especially in mild cases. The current knowledge on the use of the latter agent in this congenital bleeding condition is systematically reviewed here. Although limited, the available literature data suggest the potential role of DDAVP for either treatment of bleeding episodes or the prevention of p... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2623466 Sat, 18 Jul 2009 21:47:07 +0100 2623466 Wrong molar hemoglobin reference values—a longstanding error that should be corrected http://www.medworm.com/index.php?rid=2623467&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr5047542152u4336%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0791-xAuthors Peter Lodemann, Blood Transfusion Service Zuerich SRK Ruetistr. 19 8952 Schlieren SwitzerlandGeorg Schorer, Blood Transfusion Service Zuerich SRK Ruetistr. 19 8952 Schlieren SwitzerlandBeat M. Frey, Blood Transfusion Service Zuerich SRK Ruetistr. 19 8952 Schlieren Switzerland Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2623467 Sat, 18 Jul 2009 21:47:03 +0100 2623467 HbA2-Partinico or δ(A2)Pro→Thr, a new genetic variation in the δ-globin gene in cis to the β+ thal IVS-I-110 G>A, and the heterogeneity of δ-globin alleles in double heterozygotes for β- and δ-globin gene defects http://www.medworm.com/index.php?rid=2623468&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh5p611r223556226%2F Abstract  The study of the alleles of the δ-globin gene is relevant to the prevention of β-thalassemia homozygosis; in fact, the increase of the HbA2 is an invaluable hematological marker of the β-thalassemia heterozygosis and the double heterozygosis for alleles of δ- and β-globin genes can cause the decrease of the HbA2 up to normal or borderline values. We carried out the characterization of alleles of the δ- and β-globin genes, restriction fragment length polymorphism (RFLP) haplotype background, and hematologic phenotype in 23 double heterozygotes belonging to 18 unrelated families. A wide heterogeneity of the δ-globin alleles was detected; seven known alleles in trans to the β-globin gene defects were revealed in 17 out of 18 families, while a new allele in ci... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2623468 Sat, 18 Jul 2009 21:47:02 +0100 2623468 Cutaneous myeloma and bortezomib http://www.medworm.com/index.php?rid=2603919&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3526478818711305%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0786-7Authors Alessandro Gozzetti, Policlinico “Santa Maria alle Scotte” Division of Hematology and Transplants Viale Bracci 16 53100 Siena ItalyMarzia Defina, Policlinico “Santa Maria alle Scotte” Division of Hematology and Transplants Viale Bracci 16 53100 Siena ItalyMonica Bocchia, Policlinico “Santa Maria alle Scotte” Division of Hematology and Transplants Viale Bracci 16 53100 Siena Italy Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2603919 Tue, 14 Jul 2009 09:56:13 +0100 2603919 Therapy of hepatitis C in thalassemia: the influence of iron on achieving sustained viral response http://www.medworm.com/index.php?rid=2592411&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0235148661143654%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0785-8Authors Seyed-Moayed Alavian, Baqiyatallah University of Medical Sciences Research Center for Gastroenterology and Liver Disease Tehran IranSeyed-Vahid Tabatabaei, Baqiyatallah University of Medical Sciences Research Center for Gastroenterology and Liver Disease Tehran Iran Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2592411 Fri, 10 Jul 2009 08:09:10 +0100 2592411 Abdominal pain in a patient with acute lymphoblastic leukaemia http://www.medworm.com/index.php?rid=2592412&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg896223434856555%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0789-4Authors Alexander Breitenstein, University Hospital Zurich Department of Internal Medicine Rämistrasse 100 8091 Zurich SwitzerlandReto Kühne, University Hospital Zurich Hematology Department Zurich SwitzerlandElisabeth I. Minder, Stadtspital Triemli Zentrallabor Zurich SwitzerlandAleksandra Marek, University Hospital Zurich Hematology Department Zurich SwitzerlandJeroen Goede, University Hospital Zurich Hematology Department Zurich SwitzerlandUrs Schanz, University Hospital Zurich Hematology Department Zurich SwitzerlandChristoph Renner, University Hospital Zurich Hematology Department Zurich Switzerland Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2592412 Thu, 09 Jul 2009 12:37:13 +0100 2592412 A case of generalized MALT lymphoma with IgM paraproteinemia and peripheral blood involvement http://www.medworm.com/index.php?rid=2589884&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpj815j86661r49k5%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0787-6Authors Sonja Reitter, Medical University Graz Division of Hematology Auenbruggerplatz 38 8036 Graz AustriaPeter Neumeister, Medical University Graz Division of Hematology Auenbruggerplatz 38 8036 Graz AustriaChristine Beham-Schmid, Medical University Graz Institute of Pathology Auenbruggerplatz 25 8036 Graz AustriaWerner Emberger, Medical University Graz Institute of Human Genetics Harrachgasse 21/8 8010 Graz AustriaDirk Strunk, Medical University Graz Division of Hematology Auenbruggerplatz 38 8036 Graz AustriaRuth Brezinschek, Medical University Graz Division of Hematology Auenbruggerplatz 38 8036 Graz AustriaWerner Linkesch, Medical University Graz Division of Hematology Auenbruggerplatz 38 8036 G... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2589884 Tue, 07 Jul 2009 15:24:03 +0100 2589884 Reversible posterior leukoencephalopathy syndrome following R-CHOP therapy for diffuse large B-cell lymphoma http://www.medworm.com/index.php?rid=2589883&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp473226658g72786%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0783-xAuthors Masataka Hosoi, University of Tokyo Department of Hematology & Oncology, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanGo Yamamoto, University of Tokyo Department of Hematology & Oncology, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanYoichi Imai, University of Tokyo Department of Hematology & Oncology, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanMineo Kurokawa, University of Tokyo Department of Hematology & Oncology, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 Japan Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2589883 Tue, 07 Jul 2009 15:24:03 +0100 2589883 Increased risk of recurrent thrombosis in patients with essential thrombocythemia carrying the homozygous JAK2 V617F mutation http://www.medworm.com/index.php?rid=2589882&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F86t374361742888p%2F In conclusion, a homozygous JAK2 V617F mutation is an independent risk factor for recurrent thrombosis in patients with ET. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0788-5Authors Valerio De Stefano, Catholic University Institute of Hematology Largo Gemelli 8 00168 Rome ItalyTommaso Za, Catholic University Institute of Hematology Largo Gemelli 8 00168 Rome ItalyElena Rossi, Catholic University Institute of Hematology Largo Gemelli 8 00168 Rome ItalyAlessandro M. Vannucchi, University of Florence The Department of Hematology Florence ItalyMarco Ruggeri, San Bortolo Hospital The Hematology Department and Hemophilia and Thrombosis Center Vicenza ItalyElena Elli, University of Milano-Bicocca The Hematology Division and Bone Marrow Transplantation Unit, S... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2589882 Tue, 07 Jul 2009 15:24:03 +0100 2589882 Serum cytokines in follicular lymphoma. Correlation of TGF-β and VEGF with survival http://www.medworm.com/index.php?rid=2589885&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff8556603p2345553%2F Abstract  The prognosis of follicular lymphoma could vary with the tumor immune microenvironment. We evaluated the prognostic value of serum levels of ten cytokines. Our study cohort included 60 follicular lymphoma patients and 20 controls. Serum was available at diagnosis in 31 patients, at first relapse in 18, and complete remission in 11. Bioplex technology was used for determination of nine cytokines [interleukin (IL)-1Ra, IL-6, IL-7, IL-10, IL-13, tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and basic fibroblast growth factor (b-FGF)]. Transforming growth factor beta (TGF-β) was measured by sandwich enzyme-linked immunosorbent assay. IL-1Ra, IL-6, IL-7, IL-10, IL-13, TNF-α, VEGF, and PDGF leve... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2589885 Tue, 07 Jul 2009 15:24:02 +0100 2589885 Differential effects of interleukin-12 and interleukin-15 on expansion of NK cell receptor-expressing CD8+ T cells http://www.medworm.com/index.php?rid=2589887&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm022qn3658685618%2F Abstract  The cytolytic activity of cells expressing natural killer cell receptors (NKRs) depends on the balance between stimulatory and inhibitory signals. We investigated both inhibitory NK receptor (CD94/NKG2A) expression and stimulatory NKR (NKG2D) expression on T cells after stimulation with cytokines (IL-12 or IL-15). Cytolytic NKR-expressing CD8+ T cells were expanded from normal adult peripheral blood mononuclear cells using anti-CD3 monoclonal antibody and cytokines (IL-12 or IL-15). The proportion and absolute number of CD94/NKG2A-expressing T cells expanded by IL-12 were significantly larger than those of the cells expanded by IL-15. On the other hand, the proportion and absolute number of NKG2D-expressing T cells expanded by IL-15 were significantly larger than t... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2589887 Mon, 06 Jul 2009 20:14:44 +0100 2589887 Efficacy of rituximab in autoimmune hemolytic anemia associated with splenic marginal zone lymphoma http://www.medworm.com/index.php?rid=2589886&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwp57420n55n5t237%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0782-yAuthors Claudio Fozza, University of Sassari Institute of Haematology Viale San Pietro 12 07100 Sassari ItalyAntonio Galleu, University of Sassari Institute of Haematology Viale San Pietro 12 07100 Sassari ItalyMaria Grazia Careddu, University of Sassari Institute of Haematology Viale San Pietro 12 07100 Sassari ItalyDomenica Barbara Giannico, University of Sassari Institute of Haematology Viale San Pietro 12 07100 Sassari ItalySilvana Bonfigli, University of Sassari Institute of Haematology Viale San Pietro 12 07100 Sassari ItalySalvatore Contini, University of Sassari Institute of Haematology Viale San Pietro 12 07100 Sassari ItalyMaurizio Longinotti, University of Sassari Institute of Haematology V... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2589886 Mon, 06 Jul 2009 20:14:44 +0100 2589886 Toxic non-resorptive internal hydrocephalus as a result of haemorrhagic ventriculitis during induction chemotherapy of Bcr-Abl positive acute lymphoblastic leukaemia http://www.medworm.com/index.php?rid=2578297&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnu4m5m7x30263w80%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0781-zAuthors Kalina Ramadanova, University Hospital Carl Gustav Carus Dresden, Dresden University of Technology Department of Internal Medicine I Fetscherstr. 74 01307 Dresden GermanyHansjörg Hoff, University Hospital Carl Gustav Carus Dresden, Dresden University of Technology Department of Neuroradiology Fetscherstr. 74 01307 Dresden GermanyNicola Gökbuget, University Hospital Johann-Wolfgang Goethe Department of Internal Medicine II Theodor-Stern Kai 7 60590 Frankfurt/Main GermanyUlrike Reuner, University Hospital Carl Gustav Carus Dresden, Dresden University of Technology Department of Neurology Fetscherstr. 74 01307 Dresden GermanySusanne Hamann, University Hospital Carl Gustav Carus Dresden, Dresden... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2578297 Mon, 06 Jul 2009 16:50:11 +0100 2578297 A case report of non-traumatic renal artery pseudoaneurysm due to chemotherapy for diffuse large B-cell lymphoma http://www.medworm.com/index.php?rid=2578298&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw84150703l763814%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0776-9Authors Yosuke Masamoto, University of Tokyo Department of Hematology & Oncology, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanYoichi Imai, University of Tokyo Department of Hematology & Oncology, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanSachiko Seo, University of Tokyo Department of Hematology & Oncology, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 JapanMasaaki Akahane, University of Tokyo Department of Radiology, Graduate School of Medicine Tokyo JapanMineo Kurokawa, University of Tokyo Department of Hematology & Oncology, Graduate School of Medicine 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8655 Japan Journal Annals of Hema... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2578298 Mon, 06 Jul 2009 16:50:10 +0100 2578298 Thrombocytopenia as first manifestation of splenic angiosarcoma http://www.medworm.com/index.php?rid=2565099&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr3q00x268gn26412%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0778-7Authors Simon Raffel, Charité Campus Virchow Klinikum Department of Hematology and Oncology Augustenburger Platz 1 13353 Berlin GermanyBert Hildebrandt, Charité Campus Virchow Klinikum Department of Hematology and Oncology Augustenburger Platz 1 13353 Berlin GermanyChristian Grieser, Charité Campus Virchow Klinikum Department of Radiology Augustenburger Platz 1 13353 Berlin GermanyStefan Pahl, Charité Campus Mitte Institute of Pathology Charitéplatz 1 10117 Berlin GermanyIsrid Sturm, Charité Campus Virchow Klinikum Department of Hematology and Oncology Augustenburger Platz 1 13353 Berlin Germany Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hemat... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2565099 Wed, 01 Jul 2009 06:13:18 +0100 2565099 Predictors of hematological abnormalities in patients with chronic hepatitis C treated with interferon and ribavirin http://www.medworm.com/index.php?rid=2565100&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy727411813210568%2F This study identifies pretreatment parameters that may help identify high-risk patients who are more likely to develop hematological abnormalities during treatment for chronic hepatitis C. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00277-009-0774-yAuthors Jagdish S. Nachnani, University of Missouri Kansas City School of Medicine Division of Gastroenterology 2301 Holmes Street Kansas City MO 64108 USAGowtham A. Rao, VA Medical Center Kansas City Division of Gastroenterology Kansas City MO 64108 USADeepti Bulchandani, VA Medical Center Kansas City Division of Gastroenterology Kansas City MO 64108 USAPrashant K. Pandya, VA Medical Center Kansas City Division of Gastroenterology Kansas City MO 64108 USALaura M. Alba, University of Missouri Kansas City School of Me... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2565100 Tue, 30 Jun 2009 15:40:17 +0100 2565100 Lenalidomide in 5q minus myelodysplastic syndrome: how long is enough? http://www.medworm.com/index.php?rid=2557994&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft7700283t0w040g7%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0775-xAuthors Donat Dürr, Stadtspital Triemli Medical Oncology Birmensdorferstrasse 497 CH-8063 Zurich SwitzerlandRaffaele Daniele Siciliano, Stadtspital Triemli Medical Oncology Birmensdorferstrasse 497 CH-8063 Zurich SwitzerlandYvonne Hummel, Stadtspital Triemli Medical Oncology Birmensdorferstrasse 497 CH-8063 Zurich SwitzerlandAlix O’Meara, Stadtspital Triemli Medical Oncology Birmensdorferstrasse 497 CH-8063 Zurich SwitzerlandAnita Hirschi, Stadtspital Triemli Medical Oncology Birmensdorferstrasse 497 CH-8063 Zurich SwitzerlandRoger Burkhard, Stadtspital Triemli Medical Oncology Birmensdorferstrasse 497 CH-8063 Zurich SwitzerlandHanspeter Honegger, Stadtspital Triemli Medical Oncology Birmensdorfers... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=2557994 Mon, 29 Jun 2009 09:59:28 +0100 2557994