MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Annals of Hematology' source. Wed, 08 Feb 2012 17:41:56 +0100 http://www.medworm.com/index.php?rid=5668115&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft0524q54235q000m%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-012-1417-2Authors Yasuhisa Yokoyama, Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, JapanKazumi Suzukawa, Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, JapanYasushi Okoshi, Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, JapanToru Nanmoku, Department of Clinical Laboratory, Tsukuba University Hospital, Tsukuba, Ibaraki, JapanNaoshi Obara, Department of Hematology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, JapanTerukazu Enami, Department of Hematology, Faculty of Medicine, University of Tsukuba, ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5668115 Fri, 03 Feb 2012 17:12:41 +0100 5668115 http://www.medworm.com/index.php?rid=5668116&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F03646h275m108721%2F Abstract  Mobilization and collection of stem cells is difficult in a proportion of patients intended for autologous stem cell transplantation (ASCT). We have evaluated mobilization kinetics of blood CD34+ cells (B-CD34+) to form basis for algorithm to facilitate rational pre-emptive plerixafor use. Altogether 390 chemomobilized patients were included. Forty-three patients (11%) did not reach B-CD34+ count ≥10 × 106/l. Mobilization kinetics differed according to the mobilization capacity observed. Among those who were very poor or inadequate mobilizers (peak B-CD34+ count ≤5 × 106/l and 6–10 × 106/l, respectively), B-CD34+ counts rarely rose after white blood cells (WBC) >5–10 × 109/l, whereas in many standard mobilizers a later rise in CD34+ cou... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5668116 Thu, 02 Feb 2012 18:15:06 +0100 5668116 http://www.medworm.com/index.php?rid=5668117&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh2j7577372w7r833%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-012-1419-0Authors Ken Morita, Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanFumihiko Nakamura, Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanYasuhito Nannya, Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanAkira Nomiya, Department of Urology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanShunya Arai, Department of Hematology and Oncology, Graduate School of Medicine, The University... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5668117 Thu, 02 Feb 2012 06:56:37 +0100 5668117 http://www.medworm.com/index.php?rid=5649296&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff0318lh12421142r%2F Abstract  Extramedullary (e) relapse in multiple myeloma (MM) has an adverse prognosis, but knowledge concerning biological features and preferred treatment is scarce. We screened the myeloma registry of our institution for eMM relapses and identified 24 cases among 357 patients (pts). Only 8% of eMM relapses occurred after initial therapy, but 54% occurred after third-line or subsequent therapy. Baseline molecular cytogenetics revealed high-risk features in 10 of 19 evaluable patients. Most frequently, eMM presented as soft tissue (67%) and organ involvement (25%) or malignant effusion (12.5%). Incidence of leptomeningeal/CNS involvement was 21%. At eMM relapse, bone marrow infiltration was absent in 46% and low in 21%. Ten eMM biopsies were available showing increased pro... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5649296 Mon, 30 Jan 2012 06:32:07 +0100 5649296 http://www.medworm.com/index.php?rid=5649298&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff152218uj3421578%2F Abstract  The association between iron overload indices and pathology of the heart and liver in transfusion-dependent patients with β thalassemia major (TM) has been extensively studied. Nonetheless, data on endocrine disease remains limited. This was a cross-sectional study of 382 TM patients treated with regular transfusions and desferrioxamine at the Thalassemia Center in Dubai, UAE. Retrieved data included demographics, splenectomy status, steady-state serum ferritin levels, and the presence of endocrinopathies (diabetes mellitus, hypothyroidism, hypoparathyroidism, and hypogonadism). Multivariate logistic regression analyses were used to determine which variables were independently associated with the occurrence of each endocrinopathy. The mean age of patients was 15.... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5649298 Fri, 27 Jan 2012 06:53:43 +0100 5649298 http://www.medworm.com/index.php?rid=5649297&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp775008183w714qm%2F Abstract  Although all patients with paroxysmal nocturnal hemoglobinuria (PNH) have acquired mutations in the phosphatidylinositol glycan class-A(PIG-A)gene, their clinical courses are highly variable. We reviewed 280 PNH cases referred to our hospital from January 1990 through June 2010 to assess clinical presentations, prognostic factors influencing survival, difference among subcategories, and clinical significance of PNH clone size. The overall survival at 10 years after diagnosis estimated by Kaplan–Meier was 77.6%. Both univariate and multivariate analyses identified risk factors affecting survival, including age >40 years, absolute neutrophil count<0.5 × 109 cells/L, development of thrombotic events, evolution to myelodysplastic syndrome or acut... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5649297 Fri, 27 Jan 2012 06:53:43 +0100 5649297 http://www.medworm.com/index.php?rid=5649299&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn04p64083wpqx7wm%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-012-1410-9Authors Yuki Hiroshima, Third Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2, Iidanishi, Yamagata-shi, Yamagata, 990-9585 JapanKatsushi Tajima, Third Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2, Iidanishi, Yamagata-shi, Yamagata, 990-9585 JapanYousuke Shiono, Third Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2, Iidanishi, Yamagata-shi, Yamagata, 990-9585 JapanIkuko Suzuki, Third Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2, Iidanishi, Yamagata-shi, Yamagata, 990-9585 JapanKei Kouno, Third Department of Internal Medicine, Yamagata University School of Medicine, ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5649299 Fri, 27 Jan 2012 06:53:41 +0100 5649299 http://www.medworm.com/index.php?rid=5639125&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9033818jlp262132%2F In conclusion, we found that anti-HBs titers decreased significantly (P < 0.001) after rituximab treatment. B cell lymphoma patients with low pre-treatment anti-HBs titers (<100 mIU/mL) were more likely to lose anti-HBs antibodies and were at risk of HBV reactivation after rituximab immunochemotherapy. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00277-012-1405-6Authors Sung-Nan Pei, Division of Hema-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanMing-Chun Ma, Division of Hema-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanMing-Chung Wang, Div... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5639125 Tue, 24 Jan 2012 12:25:51 +0100 5639125 http://www.medworm.com/index.php?rid=5639127&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff077gt11833p7481%2F Abstract  Hemoglobin Rush is an unstable variant generated by a mutation of the β-globin gene which causes amino acid replacement Glu>Gln in the central cavity of hemoglobin (G3). Many members of a Brazilian family of Italian descent have hemoglobin Rush. This is the second report in world literature. Clinical and laboratory features were retrieved and gene mutation was characterized. Hemoglobin electrophoresis, gene sequencing, and restriction fragment length polymorphism with Hpy188I were used to characterize it. In 13 affected members, hemoglobin ranged from 9.3 to 13.0 g/dL and reticulocyte count up to 12.8%. The intensity of hemolysis appeared to be linked to increased stress. The mutation was proved to be HBB:c.304G>C, beta 101(G3) Glu>Gln. Heterozygous ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5639127 Tue, 24 Jan 2012 12:25:50 +0100 5639127 http://www.medworm.com/index.php?rid=5639126&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp71v078l56414126%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-012-1408-3Authors Jalil Ur Rehman, Department of Oncology, King Faisal Specialist Hospital and Research Centre, Po Box 40047, Jeddah, 21499 Kingdom of Saudi ArabiaNezar Bhabri, Department of Medicine, King Faisal Specialist Hospital and Research Centre, Jeddah, Kingdom of Saudi ArabiaAhmed Waleed, Department of Medicine, King Faisal Specialist Hospital and Research Centre, Jeddah, Kingdom of Saudi ArabiaA. Maulawi, Department of Pathology, King Faisal Specialist Hospital and Research Centre, Jeddah, Kingdom of Saudi ArabiaM. Aslam, Department of Oncology, King Faisal Specialist Hospital and Research Centre, Po Box 40047, Jeddah, 21499 Kingdom of Saudi Arabia Journal Annals of HematologyOnline IS... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5639126 Tue, 24 Jan 2012 12:25:50 +0100 5639126 http://www.medworm.com/index.php?rid=5620904&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl7133220l34l0155%2F Abstract  Ex vivo expansion of hematopoietic stem cells (HSCs) depends on HSC self-renewing proliferation and functional maintenance, which can be negatively affected by HSC differentiation, apoptosis, and senescence. Therefore, inhibition of HSC senescence may promote HSC expansion. To test this hypothesis, we examined the effect of inhibition of p38 mitogen-activated protein kinase (p38) on the expansion of human umbilical cord blood (hUCB) CD133+ cells because activation of p38 has been implicated in the induction of HSC senescence under various physiological and pathological conditions. Our results showed that ex vivo expansion of hUCB CD133+ cells activated p38, which was abrogated by the p38 specific inhibitor SB203580 (SB). Inhibition of p38 activity with SB promoted ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5620904 Thu, 19 Jan 2012 08:04:29 +0100 5620904 http://www.medworm.com/index.php?rid=5620905&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk8k4200310jp73l3%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1396-8Authors Ana B. Fernández, Anaesthesiology and Intensive Care Department, Nuestra Sra de Candelaria University Hospital, Tenerife, Canary Islands, SpainAzahara Sancho de Ávila, Anaesthesiology and Intensive Care Department, Nuestra Sra de Candelaria University Hospital, Tenerife, Canary Islands, Spain Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5620905 Thu, 19 Jan 2012 08:04:28 +0100 5620905 http://www.medworm.com/index.php?rid=5620906&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1t35586381345764%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-012-1409-2Authors Yini Wang, Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaZhao Wang, Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaHua Chen, Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaXiaolin Wang, Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5620906 Tue, 17 Jan 2012 07:12:46 +0100 5620906 http://www.medworm.com/index.php?rid=5620907&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg618414n7v2310n2%2F In conclusion, we suggest a rigorous real-time PCR monitoring for high-risk patients or patients with signs of infections suspicious for toxoplasmosis, even though low-copy results are presently difficult to interpret. Our reported cases might also encourage the use of trimethoprim–sufmethoxazole instead of pentamidine for PcP prophylaxis in those patients. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00277-012-1406-5Authors Christoph Busemann, Department of Internal Medicine C (Haematology and Oncology, Marrow Transplantation), Ernst-Moritz-Arndt-University Greifswald, Ferdinand-Sauerbruch-Str, 17475 Greifswald, GermanySilvia Ribback, Institute for Pathology, Ernst-Moritz-Arndt-University Greifswald, Ferdinand-Sauerbruch-Str, 17475 Greifswald, Germ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5620907 Tue, 17 Jan 2012 07:12:45 +0100 5620907 http://www.medworm.com/index.php?rid=5620908&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp31871j13p2u8585%2F Abstract  Diffuse large B-cell lymphomas (DLBCL) express CD20. CD20 expression is described as negative, weak, or normal as determined by flow cytometry (FCM) and is an important target for the treatment of DLBCL. However, the impact of CD20 levels at onset of the disease on patient prognosis has not been fully elucidated. We analyzed 174 DLBCL cases newly diagnosed between January 1998 and April 2010. The relationship of the association between CD20 levels and patients’ backgrounds and prognoses was analyzed using the Kaplan–Meier method and Cox proportional hazard regression. Of the 174 patients, three cases (1.7%) were defined as CD20 negative based on immunohistochemistry (IHC). Although the other 171 cases were positive by IHC, eight cases (4.7%) were defined as ne... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5620908 Tue, 17 Jan 2012 07:12:44 +0100 5620908 http://www.medworm.com/index.php?rid=5620909&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7702273840jr1k42%2F Abstract  The Q248H mutation in the gene SLC40A1 which encodes for the cellular iron exporter ferroportin is relatively common in Africa. This mutation has been associated with resistance to hepcidin and therefore we hypothesized that iron-related parameters and the prevalence of opportunistic infections in HIV might be influenced by the Q248H mutation. We conducted a cross-sectional study among 200 HIV-positive women in the Butare University Teaching Hospital in Rwanda. Polymerase chain reaction (PCR) and restriction enzyme digestion were used to identify the Q248H mutation. Physical examination was carried out and WHO HIV disease stage classification, complete blood count, CD4 count, indirect measures of iron status, serum hepcidin, and C-reactive protein concentrations w... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5620909 Tue, 17 Jan 2012 07:12:40 +0100 5620909 http://www.medworm.com/index.php?rid=5598823&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fum4u206144437v3t%2F Abstract  Patients who relapse after an autologous hematopoietic stem cell transplantation (SCT) have a very poor prognosis. We have retrospectively analyzed diffuse large B cell lymphoma patients who underwent an allo-SCT after an auto-SCT relapse reported in the Gruppo Italiano Trapianto di Midollo Osseo (GITMO) database. From 1995 to 2008, 3449 autologous transplants were reported in the GITMO database. Eight hundred eighty-four patients relapsed or progressed after transplant; 165 patients, 19% of the relapsed patients, were treated with allo-transplant. The stem cell donor was related to the patient in 108 cases. A reduced intensity conditioning regimen was used in 116. After allo-SCT, 72 patients (43%) obtained a complete response and 9 obtained a partial response wit... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5598823 Fri, 13 Jan 2012 16:58:16 +0100 5598823 http://www.medworm.com/index.php?rid=5598825&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp720724037768664%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1398-6Authors Giorgia Battipaglia, Department of Biochemistry and Medical Biotechnology, Federico II University, via Pansini 5, 80131 Naples, ItalySimona Avilia, Department of Biochemistry and Medical Biotechnology, Federico II University, via Pansini 5, 80131 Naples, ItalyEmanuela Morelli, Department of Biochemistry and Medical Biotechnology, Federico II University, via Pansini 5, 80131 Naples, ItalyFerdinando Caranci, Diagnostic Imaging and Radiotherapy, Federico II University, Naples, ItalyFabiana Perna, Department of Biochemistry and Medical Biotechnology, Federico II University, via Pansini 5, 80131 Naples, ItalyAndrea Camera, Department of Biochemistry and Medical Biotechnology, Federico II U... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5598825 Thu, 12 Jan 2012 06:42:55 +0100 5598825 http://www.medworm.com/index.php?rid=5598824&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy88135488425630m%2F Abstract  Renal impairment (RI) is a frequent complication with higher incidence of infections and an important prognostic factor for survival. Melphalan clearance is renal function dependent whereas cyclophosphamide is renal function independent. We investigated which combination regimen should be selected between melphalan-combining regimen (MPT) or cyclophosphamide-combining regimen (TCD) in elderly multiple myeloma (MM) patients with RI. Between 2005 and 2009, 157 newly diagnosed MM patients with RI were included comparing MPT with TCD therapy as initial treatment. Seventy-four patients were given MPT regimen, and 83 patients were given TCD regimen. Baseline characteristics were similar between the MPT and TCD groups. Analysis of different cutoff levels between 25% and ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5598824 Thu, 12 Jan 2012 06:42:55 +0100 5598824 http://www.medworm.com/index.php?rid=5583444&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq3254q41365rp33n%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1399-5Authors Alaa Muslimani, Department of Hematology and Oncology, Oakland University William Beaumont School of Medicine, William Beaumont Hospital, 3577 W 13 Mile Rd, Suite 202, Royal Oak, MI 48073, USAMohammad Muhsin Chisti, Department of Hematology and Oncology, Oakland University William Beaumont School of Medicine, William Beaumont Hospital, 3577 W 13 Mile Rd, Suite 202, Royal Oak, MI 48073, USAAnn Marie Blenc, Department of Pathology, Oakland University William Beaumont School of Medicine, William Beaumont Hospital, 3601 W 13 Mile Rd, Royal Oak, MI 48073, USAIqbal Boxwala, Department of Hematology and Oncology, Oakland University William Beaumont School of Medicine, William Beaumont Hospit... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5583444 Wed, 11 Jan 2012 06:57:54 +0100 5583444 http://www.medworm.com/index.php?rid=5583445&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgj1t713501h1h75t%2F Abstract  Allogeneic hematopoietic stem cell transplantation (HSCT) in childhood is associated with severe pulmonary complications, but the pathophysiologic mechanisms remain unclear. Our aim was to evaluate the association of total and specific IgE, eosinophil cationic protein (ECP) and eosinophilia in HSCT recipients with pulmonary complications. We prospectively measured total and specific serum IgE, eosinophils, and ECP before and 28, 100, and 180 days after HSCT. We included 30 children (age 2–17 years) undergoing HSCT. Nine patients had a history of previous atopy without being associated with pulmonary complications after HSCT until day +360. Specific IgE levels showed a decline after HSCT, associated with the absence of allergy symptoms, suggesting a red... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5583445 Wed, 11 Jan 2012 06:57:53 +0100 5583445 http://www.medworm.com/index.php?rid=5583446&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu626703g562881n1%2F Abstract  Association of trough imatinib plasma levels (IPL) with cytogenetic or molecular response to treatment in patients with chronic myeloid leukemia (CML) was repeatedly reported. We analyzed their value in the routine clinical setting in 131 patients with chronic phase CML in whom imatinib was applied as first- or second-line treatment. A total of 1,118 measurements were obtained by ultra-performance liquid chromatography–tandem mass spectrometry assay in patients treated with daily dose of imatinib ranging from 100 to 800 mg. Samples were obtained from 1 to 96 h after drug ingestion. High inter (36%) and intraindividual variability (9–33%) of IPL was observed. For analysis of correlation of IPL with treatment response, two sets of samples were selected... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5583446 Tue, 10 Jan 2012 06:46:46 +0100 5583446 http://www.medworm.com/index.php?rid=5583447&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb22wr5x144311268%2F Abstract  Single-agent bortezomib, a potent, selective, and reversible inhibitor of the 26S proteasome, has demonstrated clinical efficacy in relapsed and refractory mantle cell lymphoma (MCL). Objective response is achieved in up to 45% of the MCL patients; however, complete remission rates are low and duration of response proved to be relatively short. These limitations may be overcome by combining proteasome inhibition with conventional chemotherapy. Rational combination treatment and schedules require profound knowledge of underlying molecular mechanisms. Here we show that single-agent bortezomib treatment of MCL cell lines leads to G2/M arrest and induction of apoptosis accompanied by downregulation of EIF4E and CCND1 mRNA but upregulation of p15(INK4B) and p21 mRNA. W... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5583447 Tue, 10 Jan 2012 06:46:45 +0100 5583447 http://www.medworm.com/index.php?rid=5561304&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff261204x04p37411%2F Abstract  To assess the effectiveness of the search for an unrelated donor on the outcome of patients with high-risk acute lymphoblastic leukemia, we analyzed prospectively 136 patients who underwent a search for cord blood (CB) and an unrelated volunteer donor (UD) at the same time. The probability of finding a donor was 58.2%, 70.3%, and 75.7% at 3, 6, and 12 months, respectively. The median time to find a donor was 1.8 months for CB and 3.5 months for UD. Of the 99 patients with a donor, 38.4% failed to undergo the transplant because of a relapse observed at a median of 4 months from the start of the search. In univariate analysis, absence of relapse during the search (p < 0.0001) and transplant (p = 0.004) showed a positive impact on long-t... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5561304 Mon, 02 Jan 2012 06:58:18 +0100 5561304 http://www.medworm.com/index.php?rid=5561305&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5427101457431826%2F In conclusion, CLL/PLL with MYC translocations is a rare entity, which seems to be associated with adverse prognostic features and unfavorable outcome. Content Type Journal ArticleCategory Original ArticlePages 1-11DOI 10.1007/s00277-011-1393-yAuthors Natalie Put, Center for Human Genetics, Catholic University of Leuven, Herestraat 49, 3000 Leuven, BelgiumKatrien Van Roosbroeck, Center for Human Genetics, Catholic University of Leuven, Herestraat 49, 3000 Leuven, BelgiumPeter Konings, Department of Electrical Engineering/IBBT-K.U. Leuven Future Health Department, Catholic University of Leuven, Leuven, BelgiumPeter Meeus, Center for Human Genetics, Catholic University of Leuven, Herestraat 49, 3000 Leuven, BelgiumCaroline Brusselmans, Department of Clinical Biology, University Hospit... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5561305 Thu, 29 Dec 2011 06:42:41 +0100 5561305 http://www.medworm.com/index.php?rid=5553050&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd7n3q538p577081u%2F Abstract  Fifty-four adult German patients suffering from idiopathic thrombotic thrombocytopenic purpura (TTP) have been examined for HLA class II. All patients presented autoantibodies against ADAMTS13 and ADAMTS13 activity levels <5%. Blood samples have been analyzed for HLA-DRB1 and DQB1 alleles using sequence-specific primer PCR and sequence-specific oligonucleotide PCR. Reference data of German bone marrow and blood donors were obtained from www.allelefrequencies.net. The results were evaluated employing two-sided binomial tests, and p values were corrected using the Benjamini–Hochberg procedure. A significant accumulation for DQB1*02:02 (p < 0.001) and DRB1*11 (p = 0.003) was found within the patient group. Twenty percent (DQB1*02:02) or 48.1% (DRB1*11) o... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5553050 Tue, 27 Dec 2011 16:51:21 +0100 5553050 http://www.medworm.com/index.php?rid=5553051&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fllm818u7473pkx6l%2F Abstract  Combination of standard chemotherapy with rituximab led to improved disease control in patients with B cell lymphoma in clinical trials. We wanted to know if a similar benefit could be demonstrated in the routine data of a regional population-based cancer registry. We searched the registry of the Regensburg Tumor Center for B cell non-Hodgkin lymphomas diagnosed between 1998 and 2006 and compared overall survival of patients receiving any first-line chemotherapy with or without rituximab. Comparing registry data to death certificates, an 86% coverage within the registry was estimated. In the aggressive lymphoma group, 133 patients received rituximab-containing chemotherapy resulting in a 5-year survival of 69.6%, whereas 205 patients received chemotherapy alone wi... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5553051 Tue, 27 Dec 2011 06:33:55 +0100 5553051 http://www.medworm.com/index.php?rid=5545195&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F46144072v0u43942%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1389-7Authors Wei Wang, Hematology Department, Huashan Hospital of Fudan University, Wulumuqi Central Road No 12, Shanghai, 200040 ChinaHong Wang, Hematology Department, Huashan Hospital of Fudan University, Wulumuqi Central Road No 12, Shanghai, 200040 ChinaXiao-Qin Wang, Hematology Department, Huashan Hospital of Fudan University, Wulumuqi Central Road No 12, Shanghai, 200040 ChinaGuo-Wei Lin, Hematology Department, Huashan Hospital of Fudan University, Wulumuqi Central Road No 12, Shanghai, 200040 China Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5545195 Thu, 22 Dec 2011 12:51:03 +0100 5545195 http://www.medworm.com/index.php?rid=5545196&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftq78781675282384%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1391-0Authors Arwa Z. Al-Riyami, Division of Hematological Pathology, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, CanadaPeter W. K. Tsang, Division of Hematology, University of British Columbia, Vancouver, BC, CanadaMonika Hudoba, Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5545196 Thu, 22 Dec 2011 12:51:02 +0100 5545196 http://www.medworm.com/index.php?rid=5545197&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft58462482144t263%2F Abstract  Mucosa-associated lymphoid tissue (MALT) lymphomas are B cell neoplasms which commonly affect the gastrointestinal (GI) tract. Gastrointestinal MALT lymphomas rarely show plasmacytic differentiation (PCD), and limited data on the potential influence of the anti-CD20 antibody rituximab (R) on PCD exist in the current literature. We have retrospectively analyzed patients with GI MALT lymphomas treated with R-containing regimens because restaging is routinely performed by repeated biopsies with pathohistological response assessment. Twenty-one patients with GI MALT lymphoma were identified to have undergone R-containing therapy. In 19 patients, the lymphoma originated in the stomach, while the colon was the primarily affected organ in two cases. Four patients receive... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5545197 Wed, 21 Dec 2011 19:46:42 +0100 5545197 http://www.medworm.com/index.php?rid=5545198&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F23wp023633467108%2F In conclusion, our findings suggest an association between HBV infection and development of CD. CD patients with HBV infection have their own distinguished features. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s00277-011-1388-8Authors Xiang-Gui Yuan, The Second Affiliated Hospital (Binjiang Branch), School of Medicine, Zhejiang University; Department of Internal Medicine, Hangzhou Binjiang Hospital, Hangzhou, China 310009Fei-Fei Chen, Department of Hematology, the First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, China 310003Yi-Miao Zhu, The Second Affiliated Hospital (Binjiang Branch), School of Medicine, Zhejiang University; Department of Internal Medicine, Hangzhou Binjiang Hospital, Hangzhou, China 310... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5545198 Wed, 21 Dec 2011 19:46:41 +0100 5545198 http://www.medworm.com/index.php?rid=5538777&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flt3240k353345797%2F Abstract  A sensitive and specific sandwich ELISA was developed for the diagnosis of Glanzmann’s thrombasthenia (GT) and the heterozygote carriers of the disease using whole blood platelets. The assay used anti-CD36 antibody to capture platelets from platelet-rich plasma which was subsequently treated with a bioengineered disintegrin/alkaline phosphatase hybrid protein specific for GP IIb/IIIa. The test allows large number of samples to be typed and can also be used on stored samples. The assay correctly diagnosed 40 normal healthy individuals, 10 GT cases, 10 heterozygotes, 3 Bernard–Soulier syndrome cases and 2 type 3 GT cases. ELISA plates were stable at room temperature up to 3 weeks without any loss of activity. This novel and simple test can be widely used fo... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5538777 Tue, 20 Dec 2011 06:43:20 +0100 5538777 http://www.medworm.com/index.php?rid=5538778&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F480t365827tpu1r6%2F Abstract  Serum concentration of soluble interleukin-2 receptor (sIL-2R) predicts the clinical outcome of patients with aggressive non-Hodgkin's lymphoma treated with the cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) regimen without rituximab. In the present study, we aim to re-assess the prognostic significance of serum sIL-2R for diffuse large B cell lymphoma (DLBCL) patients treated with CHOP plus rituximab and to assess sIL-2R with subtype of DLBCL, such as GCB type and non-GCB type. Two hundred and thirty-three patients with DLBCL were enrolled between December 2002 and March 2008. To evaluate serum levels of sIL-2R, venous blood samples were drawn from patients immediately before initiation of treatment. Serum sIL-2R was determined by sandwich en... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5538778 Tue, 20 Dec 2011 06:43:19 +0100 5538778 http://www.medworm.com/index.php?rid=5516056&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flu70003761741366%2F Abstract  Acute kidney injury (AKI) is frequent in multiple myeloma (MM) patients and strongly affects prognosis, with particularly poor outcomes in patients requiring hemodialysis. Introduction of the novel therapeutic agents to MM therapy has improved myeloma response and renal outcome. This case series reviews the efficacy of combined systemic and extracorporeal therapy to further optimize time to light chain (serum-free light chain (sFLC)) reduction and renal recovery in MM patients with dialysis-dependent AKI (n = 19). High cut-off (HCO) hemodialysis for extracorporeal sFLC removal was initiated in parallel to chemotherapy. Combined therapy resulted in early sFLC response after a median of 13 (range 4–48) days and 6 (3–22) HCO hemodialysis sessions. Time to sFL... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5516056 Wed, 14 Dec 2011 16:31:04 +0100 5516056 http://www.medworm.com/index.php?rid=5516057&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl007t21154232214%2F Abstract  In thalassemia intermedia (TI), the increase in bone marrow hemopoietic activity frequently leads to extramedullary erythropoeisis (EMH), but its relationship with the soluble form of transferrin receptor (sTfR) which fully reflects the marrow erythropoietic activity, has not yet been explored. From January 2007 to December 2010, all TI patients attending at our center were prospectively enrolled to undergo sTfR assay and MRI or CT (if claustrophobic) scan evaluation for the presence of paraspinal EMH. A total of 59 patients with TI were studied; EMH involved 23 (39%) patients; overall, the concentration of sTfR varied from 2.6 to 20.6 (mean = 8.7) mg/L, but in splenectomized group and in unsplenectomized group, it varied from 4.2 to 17.8 (mean ± SD = ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5516057 Wed, 14 Dec 2011 06:57:33 +0100 5516057 http://www.medworm.com/index.php?rid=5506144&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F77701032274m2317%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1382-1Authors Jignesh G. Parikh, Department of Pathology, University of Tennessee Health Science Center, Memphis, TN, USAEugene Pearlman, Department of Pathology, University of Tennessee Health Science Center, Memphis, TN, USA Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5506144 Mon, 12 Dec 2011 06:33:04 +0100 5506144 http://www.medworm.com/index.php?rid=5495498&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv447rpl124k04r14%2F Abstract  The purpose of the study is to evaluate the 10 years follow-up of the efficacy in Chinese patients receiving cyclophosphamide, doxorubicin/epirubicin, vincristine, and prednisone (CHOP) or rituximab plus CHOP (R-CHOP) regimen as the initial treatment for diffuse large B cell lymphoma (DLBCL). We have retrospectively analyzed 437 patients with DLBCL who were newly diagnosed and received CHOP or R-CHOP regimen in six university hospitals and closely followed up after the completion of treatment. For all patients, there were significant differences between R-CHOP and CHOP for overall survival (OS) (median follow-up 86 months, 84.1% vs 70.2%, p = 0.018) and progression-free survival (PFS) (81.5% vs 66.7%, p = 0.015), while elder patients (>60 ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5495498 Thu, 08 Dec 2011 07:21:23 +0100 5495498 http://www.medworm.com/index.php?rid=5495499&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcxu65432713747vj%2F Abstract  This review focuses on the prevention and treatment of anemia in women who have just given childbirth (postpartum anemia). The problem of anemia both prepartum and postpartum is far more prevalent in developing countries than in the Western societies. The conditions for mother and child in the postpartum, nursing, and lactation period should be as favorable as possible. Many young mothers have a troublesome life due to iron deficiency and iron deficiency anemia (IDA) causing a plethora of symptoms including fatigue, physical disability, cognitive problems, and psychiatric disorders. Routine screening for postpartum anemia should be considered as part of the national maternal health programs. Major causes of postpartum anemia are prepartum iron deficiency and IDA i... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5495499 Thu, 08 Dec 2011 07:21:21 +0100 5495499 http://www.medworm.com/index.php?rid=5487920&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm8817g44jr855585%2F Abstract  Although hemophagocytic syndrome (HS) featuring secondary hemophagocytic lymphohistiocytosis (HLH) has a grave prognosis, little is known about the natural course of the disease. Patients who showed the clinical features of HLH as well as tissue-proven hemophagocytosis when seen at Asan Medical Center between 1999 and 2010 were included in this analysis. Patients with proven lymphoma were excluded. The median age of our 23 study patients was 49 years. Epstein–Barr virus was suspected to have caused HS in 16 (70%) patients and hepatitis A virus in one patient. Twenty-two patients were treated, 13 according to the HLH protocol and nine using immunosuppressive agents such as corticosteroid and/or cyclosporine. Five patients undertook allogeneic hematopoietic c... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5487920 Wed, 07 Dec 2011 10:51:12 +0100 5487920 http://www.medworm.com/index.php?rid=5487922&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr30x5l42q14u6667%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1372-3Authors Ken Morita, Department of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanFumihiko Nakamura, Department of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanYasuhito Nannya, Department of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanYasuhiko Kamikubo, Department of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanMotoshi Ichikawa, Department of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanMineo Kurokawa, Department of Hematology & Oncology, Graduate School of Medicine, The Univers... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5487922 Tue, 06 Dec 2011 17:03:02 +0100 5487922 http://www.medworm.com/index.php?rid=5487921&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F29t1g52683518115%2F In conclusion, pre-donation hemoglobin is a useful marker identifying donors at risk of developing low hemoglobin levels. Diagnostic and therapeutic interventions should be aimed at donors presenting with hemoglobin levels near the threshold of donor deferral. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00277-011-1371-4Authors Martin Stern, Division of Hematology, Department of Internal Medicine, University Hospital Basel, Basel, SwitzerlandAlix O’Meara, Division of Hematology, Department of Internal Medicine, University Hospital Basel, Basel, SwitzerlandLaura Infanti, Blood Transfusion Center, Swiss Red Cross, Basel, Hebelstrasse 10, 4031 Basel, SwitzerlandJoerg-Peter Sigle, Blood Transfusion Center, Swiss Red Cross, Basel, Hebelstrasse 10, 4031 B... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5487921 Tue, 06 Dec 2011 17:03:02 +0100 5487921 http://www.medworm.com/index.php?rid=5477405&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F264t21332u634412%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1376-zAuthors Andrea Piccin, Department of Haematology and Bone Marrow Transplant Unit, San Maurizio Regional Hospital, Bolzano, South Tyrol, ItalyRoberto Currò Dossi, Stroke Unit, Department of Internal Medicine, San Maurizio Regional Hospital, Bolzano, South Tyrol, ItalyVincenzo Cassibba, Department of Haematology and Bone Marrow Transplant Unit, San Maurizio Regional Hospital, Bolzano, South Tyrol, ItalySigmund Stupnner, Department of Radiology, San Maurizio Regional Hospital, Bolzano, South Tyrol, ItalyGiampietro Bonatti, Department of Radiology, San Maurizio Regional Hospital, Bolzano, South Tyrol, ItalySergio Cortelazzo, Department of Haematology and Bone Marrow Transplant Unit, San Maurizio... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5477405 Fri, 02 Dec 2011 06:48:14 +0100 5477405 http://www.medworm.com/index.php?rid=5477406&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhjt122g727w12u87%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1378-xAuthors Georgia D. Kaiafa, Department of Haematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA General Hospital, 1 S. Kiriakidi St, 546 36 Thessaloniki, GreeceVasilios Perifanis, Department of Haematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA General Hospital, 1 S. Kiriakidi St, 546 36 Thessaloniki, GreeceMichael D. Diamantidis, Department of Haematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA General Hospital, 1 S. Kiriakidi St, 546 36 Thessaloniki, GreeceOlga Giouleme, Department of Gastroenterology, First Propedeutic Departm... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5477406 Fri, 02 Dec 2011 06:48:13 +0100 5477406 http://www.medworm.com/index.php?rid=5477407&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr11506259q813713%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1379-9Authors Carol Cheung, Department of Medicine, Queen Mary Hospital, Professorial Block, Pokfulam Road, Hong Kong, ChinaDavid Lopes, Department of Haematology, Hospital Conde S. Januario, Macau, ChinaKwan-Ngai Hung, Department of Surgery, Queen Mary Hospital, Hong Kong, ChinaTao Chan, Department of Diagnostic Radiology, Queen Mary Hospital, Hong Kong, ChinaKwok-Wah Chan, Department of Pathology, Queen Mary Hospital, Hong Kong, ChinaYok-Lam Kwong, Department of Medicine, Queen Mary Hospital, Professorial Block, Pokfulam Road, Hong Kong, China Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5477407 Thu, 01 Dec 2011 06:59:21 +0100 5477407 http://www.medworm.com/index.php?rid=5458897&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc3371026125w78t2%2F Abstract  The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed b... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5458897 Mon, 28 Nov 2011 16:58:16 +0100 5458897 http://www.medworm.com/index.php?rid=5450094&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw8j311l024184q66%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1374-1Authors Jecko Thachil, Department of Haematology, Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Liverpool, L7 8XP UKArvind Pillai, Department of Haematology, Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Liverpool, L7 8XP UKVanessa Martlew, Department of Haematology, Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, Liverpool, L7 8XP UK Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5450094 Wed, 23 Nov 2011 16:33:31 +0100 5450094 http://www.medworm.com/index.php?rid=5432453&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd0k2688qk5511771%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1362-5Authors Jecko Thachil, Department of Haematology, Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, L7 8XP, Liverpool, UKTim Webster, Department of Stroke Medicine, Royal Liverpool University Hospital, L7 8XP, Liverpool, UKRichard Kelly, Department of Haematology, Leeds Teaching Hospitals, Leeds, UKPeter Hillmen, Department of Haematology, Leeds Teaching Hospitals, Leeds, UKVanessa Martlew, Department of Haematology, Roald Dahl Haemostasis and Thrombosis Centre, Royal Liverpool University Hospital, L7 8XP, Liverpool, UKAnita Hill, Department of Haematology, Leeds Teaching Hospitals, Leeds, UK Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5432453 Fri, 18 Nov 2011 07:01:22 +0100 5432453 http://www.medworm.com/index.php?rid=5432454&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv68872778pm103q6%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-4DOI 10.1007/s00277-011-1366-1Authors Eun Young Lee, Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaTae Sung Park, Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of KoreaMin Jin Kim, Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of KoreaMyung Hee Chang, Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Republic of KoreaEun Hae Cho, Greencross Reference Laboratory, Yongin, Republic of KoreaSeo-Jin Park, Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaJong Rak Choi, Department of Laborator... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5432454 Fri, 18 Nov 2011 07:01:21 +0100 5432454 http://www.medworm.com/index.php?rid=5423192&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbh82t5l2g6562523%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1364-3Authors Sun Young Cho, Department of Laboratory Medicine, Kyung Hee University School of Medicine, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-702 South KoreaTae Sung Park, Department of Laboratory Medicine, Kyung Hee University School of Medicine, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-702 South KoreaSeung Hwan Oh, Department of Laboratory Medicine, College of Medicine, Inje University, GaeGeum-dong, Busanjin-gu, Busan, 614-735 South KoreaEun Hae Cho, Greencross Reference Laboratory, 314 Bojeong-dong, Kiheung-gu, Yongin-city, Gyeonggi-do, South KoreaDoyeun Oh, Division of Hematology-Oncology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Sou... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5423192 Wed, 16 Nov 2011 06:50:33 +0100 5423192 http://www.medworm.com/index.php?rid=5423193&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl07m433tp4073784%2F Abstract  The potential predictive value of tumor bulk, genetic, and immunological variants in patients with low-grade non-Hodgkin's lymphoma to respond to treatment with rituximab (RTX) monotherapy was evaluated. Thus, the value of assessing the effect of 18-fluoro-desoxy-d-glucose (FDG) uptake on PET scan, polymorphisms in Fc gamma receptor (FcγR) IIIa-158, FcγRIIa-131, and C1qA-276 genes in predicting the response to treatment were evaluated in 50 low-grade non-Hodgkin's lymphoma patients. The influence of RTX pharmacokinetics, plasma levels of the B cell-activating factor (BAFF), and human antichimeric antibodies was also investigated. The therapeutic response was evaluated 10 weeks after treatment using revised Cheson's criteria. Lower maximal standardized uptak... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5423193 Tue, 15 Nov 2011 06:49:07 +0100 5423193 http://www.medworm.com/index.php?rid=5409613&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpg0243530j725631%2F Abstract  Hypovitaminosis D (<30 ng/ml) is highly prevalent in allogeneic hematopoietic cell transplantation (alloHCT), but the relevance of influencing factors for serum 25-hydroxyvitamin D3 [25(OH)D3] status in adult patients remains unknown. We are the first to have prospectively assessed 25(OH)D3 status and its influencing factors in 102 patients before and at days +30 and +100 after alloHCT. Among others, we evaluated age, gender, weight, fat mass, season, sun exposure habits, and dietary and supplemental vitamin D intake as factors potentially influencing baseline vitamin D status in uni- and multivariate linear regression analysis. Furthermore, we investigated the impact of changes in fat mass, duration of parenteral nutrition, and acute graft-versus-host disea... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5409613 Mon, 14 Nov 2011 06:35:24 +0100 5409613 http://www.medworm.com/index.php?rid=5409614&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe28hn30gwk566187%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1367-0Authors M. Koubâa, Department of Infectious Diseases, Hedi Chaker Hospital, Sfax, 3029 TunisiaI. Mâaloul, Department of Infectious Diseases, Hedi Chaker Hospital, Sfax, 3029 TunisiaCh Marrakchi, Department of Infectious Diseases, Hedi Chaker Hospital, Sfax, 3029 TunisiaM. Mdhaffar, Department of Clinic Hematology, Habib Bourguiba Hospital, Sfax, TunisiaD. Lahiani, Department of Infectious Diseases, Hedi Chaker Hospital, Sfax, 3029 TunisiaB. Hammami, Department of Infectious Diseases, Hedi Chaker Hospital, Sfax, 3029 TunisiaF. Makni, Department of Hematology, Hedi Chaker Hospital, Sfax, 3029 TunisiaA. Ayedi, Department of Parasitology, Habib Bourguiba Hospital, Sfax, TunisiaM. Ben Jemâa, De... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5409614 Mon, 14 Nov 2011 06:35:23 +0100 5409614 http://www.medworm.com/index.php?rid=5409615&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw52kn846tj250847%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1370-5Authors Jihong Hao, Department of Clinical Laboratory, Second Hospital, Hebei Medical University, 215# Heping West Road, Shijiazhuang, 050000 ChinaShinji Kunishima, Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, 4-1-1 Sannomaru, Naka-ku, Nagoya, 460-0001 JapanXin Guo, Department of Clinical Laboratory, Second Hospital, Hebei Medical University, 215# Heping West Road, Shijiazhuang, 050000 ChinaRui Hu, Department of Clinical Laboratory, Second Hospital, Hebei Medical University, 215# Heping West Road, Shijiazhuang, 050000 ChinaWeiguo Gao, Department of Clinical Laboratory, Hospital of Hebei Engineering University, Handan, China ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5409615 Mon, 14 Nov 2011 06:35:22 +0100 5409615 http://www.medworm.com/index.php?rid=5409616&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5w21437868477w77%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1368-zAuthors Akihiro Tomita, Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya, 466-8550 JapanYukari Shirasugi, Department of Hematology and Oncology, Tokai University Hospital, Isehara, JapanTakahiko Ito, Department of Hematology, Gifu Social Insurance Hospital, Kani, JapanHisashi Tsurumi, First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, JapanTomoki Naoe, Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya, 466-8550 Japan Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hema... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5409616 Mon, 14 Nov 2011 06:35:20 +0100 5409616 http://www.medworm.com/index.php?rid=5409617&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn21g3373712t8728%2F Abstract  Harvesting sufficient progenitor cells from bone marrow (BM) for pediatric patients is a challenging process, especially from smaller donors. Growth factor administration to donors prior to harvest results in an enrichment of the graft and leads to early engraftment. A total of 41 patients received a human leukocyte antigen-identical sibling transplantation using granulocyte colony-stimulating factor (G-CSF)-primed BM. All donors received G-CSF 10 μg/kg/day for 2 days prior to harvest. The median weight difference between donor and recipient was 3.9 kg (range, −29.8 to 32 kg), and the median number of CD34+ cells harvested was 4.16 × 106/kg (range, 1.17–31.9 × 106/kg). The median time to neutrophil engraftment was 12 days (ran... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5409617 Fri, 11 Nov 2011 06:54:34 +0100 5409617 http://www.medworm.com/index.php?rid=5409618&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F65khg731k73875w3%2F The objective of this study was to investigate whether metabolic tumor volume (MTV) by positron emission tomography (PET) can be a potential prognostic tool when compared with Ann Arbor stage, in stages II and III nodal diffuse large B cell lymphoma (DLBCL). We evaluated 169 patients with nodal stages II and III DLBCL who underwent measurements with PET prior to rituximab combined with cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP). Cutoff point of MTV was measured using the receiver operating characteristic (ROC) curve. During a median period of 36 months, stage II was 59.2% and III was 40.8%. Using the ROC curve, the MTV of 220 cm3 was the cutoff value. The low MTV group (<220 cm3) had longer progression-free survival (PFS) and overall survival ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5409618 Thu, 10 Nov 2011 06:46:30 +0100 5409618 http://www.medworm.com/index.php?rid=5388863&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fht5t5764t254t0t5%2F In conclusion, our data suggest that oral deferasirox treatment may be used as a safe and effective alternative method for reducing iron overload in alloHSCT recipients, whether combined with or without phlebotomy. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00277-011-1358-1Authors Serdar Sivgin, Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, 38039 TurkeyBulent Eser, Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, 38039 TurkeySami Bahcebasi, Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, 38039 TurkeyLeylagul Kaynar, Stem Cell Transplantation Hospital, Departme... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5388863 Thu, 03 Nov 2011 16:55:07 +0100 5388863 http://www.medworm.com/index.php?rid=5388865&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmx4433170215n75h%2F Abstract  Gastrointestinal complications are frequent after allogeneic stem cell transplantation (allo-SCT). Main differential diagnoses are graft-versus-host disease (GvHD) and viral infections. In this retrospective analysis, we included 50 patients with severe vomiting or diarrhea in the first year after allo-SCT. One hundred two biopsies obtained by colonoscopy or endoscopy of the upper gastrointestinal tract were analysed by conventional histology for signs of GvHD and by qualitative polymerase chain reaction (PCR) for viral DNA of human herpesvirus 6 (HHV-6) and other virus of the herpes family. DNA of HHV-6 was detected in 38 of 75 initial samples (51%) and in 19 of 27 follow-up biopsies (70%). In the initial samples (n = 75), HHV-6 DNA was detected in 20/37 (54%)... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5388865 Wed, 02 Nov 2011 16:58:15 +0100 5388865 http://www.medworm.com/index.php?rid=5388864&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwmt6h1154776ln20%2F Abstract  Previous studies have suggested that adherence to imatinib therapy can be an obstacle among patients with chronic myeloid leukemia (CML). We studied adherence to imatinib therapy among CML patients treated at the Sahlgrenska University Hospital. We identified all CML patients that were alive at the 1st of January 2010 (n = 70). Nineteen patients were excluded due to a history of allogenic hematopoietic stem cell transplantation, and nine were excluded due to treatment with other tyrosine kinase inhibitors. Thirty-eight out of 42 patients (90%) treated with imatinib accepted inclusion in the study. The patients were interviewed in a structured way, and adherence was evaluated in a standardized way using the nine-item Morisky Medication Adherence Scale that range... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5388864 Wed, 02 Nov 2011 16:58:15 +0100 5388864 http://www.medworm.com/index.php?rid=5349002&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe0275307096t352q%2F Abstract  A recent study from Germany showed that WT1 single nucleotide polymorphism (SNP) rs16754 was an independent prognostic factor in cytogenetically normal acute myeloid leukemia (CN-AML). We analyzed clinical impact of the WT1 rs16754 genotype on disease characteristics and outcomes in Korean patients with CN-AML. A total of 73 patients with CN-AML were included in the study. All patients received standard induction chemotherapy and their bone marrow or peripheral blood samples were cryopreserved at the time of diagnosis. WT1 exons 7 and 9 were amplified using polymerase chain reaction and directly sequenced. The genotype frequency for WT1 rs16754 was 6.8% for AA, 39.7% for GA, and 53.4% for GG. G was a minor allele in German population, whereas it was a major allele i... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5349002 Thu, 20 Oct 2011 15:53:57 +0100 5349002 http://www.medworm.com/index.php?rid=5337256&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxpp6424m03x35366%2F Abstract  To evaluate the role of FDG-PET/CT in detecting bone marrow (BM) involvement, pre-treatment bilateral bone marrow biopsies (BMBs) and FDG-PET/CT scans of 89 patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab–CHOP were reviewed and analyzed. Fourteen patients (15.7%) had lymphomatous involvement based on BMB (BMB+), and 17 patients (19.1%) had the possibility of BM involvement on FDG-PET/CT (FDG-PET/CT+). Seventy-two patients (80.8%) had concordant results between BMB and FDG-PET/CT (seven patients were positive for both, and 65 patients were negative for both), but 17 patients (19.2%) had a discordant interpretation (seven patients were BMB+ and FDG-PET/CT−, and ten were BMB− and FDG-PET/CT+). Although BMB+ patients had an inferior 2-... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5337256 Tue, 18 Oct 2011 15:58:56 +0100 5337256 http://www.medworm.com/index.php?rid=5337257&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl4747632w4628572%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1356-3Authors Stefano Licci, Department of Pathology, “Santo Spirito” Hospital, Lungotevere in Sassia, 1, 00193 Rome, Italy Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5337257 Mon, 17 Oct 2011 16:04:53 +0100 5337257 http://www.medworm.com/index.php?rid=5324644&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr2366346u2w51393%2F Abstract  Cytomegalovirus (CMV) infection and disease are important concerns after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The similarity of hepatitis B virus (HBV) and CMV with regards to their chronic viral persistence and potential reactivation at the time of impaired cellular immunity has raised clinicians’ interest in the occurrence and association between them among patients receiving allo-HSCT; however, only limited data have been obtained from a high seroprevalence region of both CMV and HBV. We monitored 117 adult allo-HSCT patients with both CMV polymerase chain reaction and pp65 antigenemia assay weekly until day 100. In 91.8% of our cases, donors and recipients were both CMV seropositive, and 13.7% of the patients were positive for HBV ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5324644 Fri, 14 Oct 2011 06:09:45 +0100 5324644 http://www.medworm.com/index.php?rid=5324645&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy519hj3135205q55%2F In conclusion, IDH1/2 mutations are recurrent but rare molecular aberrations in Chinese AML and MDS. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00277-011-1352-7Authors Jiang Lin, Laboratory Center, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, People’s Republic of ChinaDong-ming Yao, Laboratory Center, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, People’s Republic of ChinaJun Qian, Department of Hematology, Affiliated People’s Hospital of Jiangsu University, 8 Dianli Rd., 212002 Zhenjiang, Jiangsu, People’s Republic of ChinaQin Chen, Department of Hematology, Affiliated People’s Hospital of Jiangsu University, 8 Dianli Rd., 212002 Zhenjiang, Jiangsu, People’s Republic ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5324645 Thu, 13 Oct 2011 15:47:04 +0100 5324645 http://www.medworm.com/index.php?rid=5316371&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0p244l18310761u3%2F Abstract  It is mandatory to perform microscopic examinations of bone marrow aspirates during the diagnosis of many neoplastic haematopoiesis disorders. In 2008, The International Committee for Standardization in Hematology recommended the use of two types of slides for the microscopic evaluation of bone marrow: wedge-spread film and crush film slides. Because these techniques have not yet been compared, we performed such a comparison. Routine bone marrow samples from 250 patients diagnosed due to different neoplastic haematological disorders were evaluated. The major differences between the two compared techniques were identified in 13 patients with non-Hodgkin’s lymphoma, seven patients with systemic mastocytosis and 11 patients with acute leukaemias or myelodysplastic ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5316371 Tue, 11 Oct 2011 15:53:26 +0100 5316371 http://www.medworm.com/index.php?rid=5316372&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy02u6847786636w4%2F In conclusion, these data suggest that serum miRNAs are potentially useful tools as novel noninvasive biomarker for the diagnosis of DLBCL. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00277-011-1350-9Authors Cheng Fang, Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing, 210029 ChinaDan-Xia Zhu, Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing, 210029 ChinaHua-Jie Dong, Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing, 210029 ChinaZhi-Jian Zhou, Department of Hematology, The Firs... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5316372 Mon, 10 Oct 2011 15:05:05 +0100 5316372 http://www.medworm.com/index.php?rid=5316373&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxh6623437m5j8246%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-1DOI 10.1007/s00277-011-1345-6Authors Federica Gigli, European Institute of Oncology—Division of Hematoncology, Milan, ItalyAngelo Gardellini, European Institute of Oncology—Division of Hematoncology, Milan, ItalyPaola Bertazzoni, European Institute of Oncology—Division of Hematoncology, Milan, ItalyGiovanni Martinelli, European Institute of Oncology—Division of Hematoncology, Milan, Italy Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5316373 Mon, 10 Oct 2011 15:05:04 +0100 5316373 http://www.medworm.com/index.php?rid=5305188&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F500317722344v740%2F Abstract  The soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) is a useful marker of infection in patients with sepsis, but has not been adequately evaluated in patients with chemotherapy-associated febrile neutropenia (FN). The value of sTREM-1 in this setting has been tested in a retrospective, pilot study using stored serum from 48 cancer patients with documented FN. On presentation, patients were categorized according to the Talcott risk-index clinical score. Circulating soluble sTREM-1 was measured using an ELISA procedure, while procalcitonin (PCT) or interleukins 6 (IL-6) and 8 (IL-8), included for comparison, were measured using an immunoluminescence-based assay and Bio-Plex® suspension bead array system, respectively. Circulating concentrations o... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5305188 Thu, 06 Oct 2011 05:49:29 +0100 5305188 http://www.medworm.com/index.php?rid=5305187&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw4177k07750475g8%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1344-7Authors Karen M. K. De Vooght, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Postbus 85500, 3508 GA Utrecht, The NetherlandsAyşe Y. Demir, Department of Clinical Chemistry and Haematology, Meander Medical Center, Amersfoort, The NetherlandsClaudia C. Folman, Sanquin Diagnostic Services, Amsterdam, The NetherlandsRoger E. G. Schutgens, Department of Haematology/Van Creveldkliniek, University Medical Center Utrecht, Utrecht, The NetherlandsWouter W. van Solinge, Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Postbus 85500, 3508 GA Utrecht, The NetherlandsHans Kemperman, Department of Clinical Chemistry and Haematology... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5305187 Thu, 06 Oct 2011 05:49:29 +0100 5305187 http://www.medworm.com/index.php?rid=5305189&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu41561048x2m2263%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1348-3Authors Larry C. Bacon, Leukemia/Bone Marrow Transplant Program of British Columbia, British Columbia Cancer Agency, Vancouver, BC, CanadaMichael J. Barnett, Leukemia/Bone Marrow Transplant Program of British Columbia, British Columbia Cancer Agency, Vancouver, BC, CanadaYasser R. Abou Mourad, Leukemia/Bone Marrow Transplant Program of British Columbia, British Columbia Cancer Agency, Vancouver, BC, Canada Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5305189 Thu, 06 Oct 2011 05:49:27 +0100 5305189 http://www.medworm.com/index.php?rid=5297772&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv6u2364tx1r074l5%2F Abstract  This retrospective case-matched study evaluated the efficacy of reduced intensity conditioning (RIC) regimen on early and late allogeneic transplant outcome in chronic myeloid leukemia (CML) patients. Twenty-eight patients conditioned with RIC regimen were matched to 56 patients who received a myeloablative conditioning (MAC) regimen. The main criteria for case matching among our CML allotransplant cohort were the Gratwohl scoring system. The median score was 2 (1–4) in each group. The pretransplant disease status was first chronic phase (CP1, n = 20), CP2 (n = 2), and advanced phase (n = 6) in RIC, and CP1 (n = 46), CP2 (n = 3), and advanced phase (n = 7) in MAC. The duration of neutropenia and thrombocytopenia was shorter in RIC than MAC.... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5297772 Wed, 05 Oct 2011 05:49:35 +0100 5297772 http://www.medworm.com/index.php?rid=5297771&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F53716jx65t765tvm%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-1DOI 10.1007/s00277-011-1346-5Authors Agustin Castiella, Gastroenterology, Mendaro Hospital, Mendaro, Gipuzkoa, SpainJose M. Alustiza, Osatek, Radiology Service, Donostia Hospital, San Sebastián, Gipuzkoa, SpainEva Zapata, Gastroenterology, Mendaro Hospital, Mendaro, Gipuzkoa, SpainJose I. Emparanza, Clinical Epidemiology Unit. Casp-e, CIBER-ESP, San Sebastián, Gipuzkoa, SpainPedro Otazua, Gastroenterology, Mondragon Hospital, Paiz Vasco, SpainLeire Zubiaurre, Gastroenterology, Mendaro Hospital, Mendaro, Gipuzkoa, SpainAlazne Aguirre, Gastroenterology, Mendaro Hospital, Mendaro, Gipuzkoa, Spain Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5297771 Wed, 05 Oct 2011 05:49:35 +0100 5297771 http://www.medworm.com/index.php?rid=5286670&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbk08221u64472350%2F In conclusion, physicians should take into consideration PROs, as “attitude” is associated with physical and mental QoL. Treatment should be tailored to patients’ needs according to comorbidities, lifestyle, and psychological conditions. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00277-011-1341-xAuthors Esther Natalie Oliva, Hematology Unit, Azienda Ospedaliera “Bianchi-Melacrino-Morelli”, Reggio Calabria, ItalyAndrea Piccin, Department of Haematology, San Maurizio Regional Hospital, Bolzano, ItalyMaria Gabriella Mazzucconi, Hematology, “Dipartimento di Biotecnologie Cellulari ed Ematologia, “Sapienza” University of Rome, Rome, ItalyEnrica Morra, Hematology Division and UTMO, Ospedale Niguarda Ca’ Granda, Milan, ItalyUmberto Recine,... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5286670 Sat, 01 Oct 2011 05:45:10 +0100 5286670 http://www.medworm.com/index.php?rid=5286671&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy414n81756545v63%2F We describe the 10-year follow-up of a patient with MLL-AF9-positive AML (Müller et al. Eur J Haematol 73:62–66, 2004), including ex vivo antileukemic immune responses which may contribute to the long-lasting spontaneous CR (tantamount to cure). We could demonstrate strong in vitro cytotoxic activity mediated by the patient’s serum (cryopreserved at diagnosis 2001) against myeloid cell lines. We also addressed cellular cytotoxic activity against myeloid leukemia cells. When the patient’s natural killer (NK) cells (obtained in 2007) were tested against the K562 cell line, upregulation of CD107 occurred, implying that long-term CR in this patient could be due to NK cell-mediated disease control. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00277... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5286671 Fri, 30 Sep 2011 05:54:03 +0100 5286671 http://www.medworm.com/index.php?rid=5286672&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj1121q8p6866r201%2F Abstract  Cancer patients with long-term venous catheter are at risk for thromboembolic complications at the catheter tip and in the adjacent venous vessels. We assessed whether local thrombogenicity could be prevented with an experimental coated (with athrombogenic layer) catheter device (CD) compared to an uncoated CD. Patients requiring a long-term venous catheter were randomly allocated to receive either a standard uncoated or experimental coated (with athrombogenic Camouflage® layer) CD. The athrombogenic layer creates a barrier against non-specific adsorption of plasma proteins. The primary endpoint was urokinase injection in cases of an unsuccessful blood aspiration from the CD. Secondary endpoints included early (haematoma, pneumothorax) and late (venous thrombosis... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5286672 Thu, 29 Sep 2011 06:18:25 +0100 5286672 http://www.medworm.com/index.php?rid=5274848&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F730q5n047462v701%2F Abstract  To evaluate, in a longitudinal study, the profile of lipid peroxidation and antioxidant capacity markers in sickle cell anaemia patients receiving different treatments and medication over different time periods. The three groups were: patients undergoing transfusion therapy and receiving iron chelator deferasirox (DFX group, n = 20); patients receiving deferasirox and hydroxyurea (DFX + HU group, n = 10), and patients receiving only folic acid (FA group, n = 15). Thiobarbituric acid-reactive substance (TBARS) assays and trolox-equivalent antioxidant capacity (TEAC) assays were evaluated during two different periods of analysis, T0 and T1 (after ~388 days). Higher FA group TBARS values were observed compared with the DFX + HU group (p = 0.016) at... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5274848 Tue, 27 Sep 2011 06:18:17 +0100 5274848 http://www.medworm.com/index.php?rid=5274847&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffn8494654150115k%2F Abstract   HFE-hemochromatosis is a common autosomal recessive disease caused by HFE gene mutations and characterized as iron overload and failure of different organs. The aim of this study was to determine the prevalence of C282Y (c.845 G > A), H63D (c.187 C > G), and S65C (c.193A > T) alleles of HFE gene in the Lithuanian population. One thousand and eleven healthy blood donors of Lithuanian nationality were examined in four different ethnic Lithuanian regions to determine HFE gene alleles and genotype frequencies. The samples of DNA were analyzed for the presence of restriction fragment length polymorphism and validated by DNA sequencing. Among 1,011 blood donors tested, the frequency of C282Y, H63D, and S65C alleles were 2.6%, 15.9%, and 1.... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5274847 Tue, 27 Sep 2011 06:18:17 +0100 5274847 http://www.medworm.com/index.php?rid=5274849&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe8151677301336jk%2F This study analyzed the outcomes of the combination of azacitidine and low-dose cytarabine in patients newly diagnosed with refractory anemia with excess blast (RAEB). Patients were treated with azacitidine 75 mg/m2 for 7 days subcutaneously and cytarabine 20 mg/m2 intravenously for 7 days every 28 days. The assigned regimen was repeated for two cycles, then the patients treated with azacytidine alone until progression or allogeneic stem cell transplantation (allo-SCT). Eighteen patients with 5 RAEB-1 and 13 RAEB-2 were enrolled in the current study. After two cycles of the combination therapy, responses were achieved in nine patients (50.0%): four complete response (CR) (22.2%), one partial response (5.6%), two marrow-CR (11.1%), and two hematologic improveme... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5274849 Tue, 27 Sep 2011 06:18:16 +0100 5274849 http://www.medworm.com/index.php?rid=5251559&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl44582n5l7h68725%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-4DOI 10.1007/s00277-011-1317-xAuthors Anna Talamo, Cancer Cytogenetics Unit, Medical Genetics Service, University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, SwitzerlandAlfio Marazzi, Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, SwitzerlandAlicia Rovo, Hematology Department, University Hospital of Basel, Basel, SwitzerlandUrs Schanz, Department of Hematology, University Hospital of Zurich, Zurich, SwitzerlandAndré Tichelli, Hematology Department, University Hospital of Basel, Basel, SwitzerlandYves Chalandon, Hematology Division, University Hospital of Geneva (HUG), Geneva, SwitzerlandMartine Jotterand, Medical Genetics Service, University Hospital and University of Lausan... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5251559 Fri, 23 Sep 2011 05:41:42 +0100 5251559 http://www.medworm.com/index.php?rid=5251560&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb706773775465510%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1335-8Authors Andrew J. Ghio, Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, NC, USA Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5251560 Thu, 22 Sep 2011 05:51:18 +0100 5251560 http://www.medworm.com/index.php?rid=5251561&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftv530x0134q20681%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1342-9Authors Rie Tabata, Department of Internal Medicine, Hyogo Prefectural Tsukaguchi Hospital, 6-8-17 Minamitsukaguchi, Amagasaki, Hyogo 661-0012, JapanChiharu Tabata, Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, JapanTomoko Nagai, Department of Internal Medicine, Hyogo Prefectural Tsukaguchi Hospital, 6-8-17 Minamitsukaguchi, Amagasaki, Hyogo 661-0012, JapanRyoji Yasumizu, Division of Pathology, Hyogo Prefectural Tsukaguchi Hospital, Hyogo, Japan Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5251561 Thu, 22 Sep 2011 05:51:17 +0100 5251561 http://www.medworm.com/index.php?rid=5251562&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg869p224u71gg406%2F Abstract  Obesity adversely affects outcome in pediatric acute lymphocytic leukemia and acute myeloid leukemia (AML). We asked if obesity, measured by body mass index (BMI), affected outcome in 329 adult AML patients treated with high-dose cytarabine and idarubicin-containing regimens administered according to actual body weight. Age ≥ 60, unfavorable karyotype, secondary AML, and positive smoking status had adverse impact on overall survival in a multivariate analysis, while BMI did not. We conclude that high BMI should not be a barrier to administer high-dose cytarabine-containing regimens for AML induction. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00277-011-1319-8Authors Hun Ju Lee, Leukemia Section, Department of Medicine, Ro... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5251562 Wed, 21 Sep 2011 05:53:12 +0100 5251562 http://www.medworm.com/index.php?rid=5251563&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F032w302422x07556%2F In conclusion, karyotype is a useful tool for risk assessment in adult ALL. We have confirmed the bad prognosis of t(4;11)(q21;q23)/MLL/AF4 and hypodiploidy. Besides, low hyperdiploidy could also define a high-risk group of patients who might be candidates for more intensive treatment. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00277-011-1331-zAuthors Inés Gómez-Seguí, Department of Hematology, Hospital Universitario La Fe, Valencia, SpainJose Cervera, Department of Hematology, Hospital Universitario La Fe, Valencia, SpainEsperanza Such, Department of Hematology, Hospital Universitario La Fe, Valencia, SpainDavid Martínez-Cuadrón, Department of Hematology, Hospital Universitario La Fe, Valencia, SpainIrene Luna, Department of Hematology, Hospit... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5251563 Wed, 21 Sep 2011 05:53:11 +0100 5251563 http://www.medworm.com/index.php?rid=5227228&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw3x01p28762j4330%2F Abstract  We conducted a multicenter, phase II trial to investigate the efficacy and safety of rituximab plus CVP (R-CVP) combination therapy for patients with previously untreated stage III or IV marginal zone lymphoma (MZL). The treatment consisted of rituximab 375 mg/m2, cyclophosphamide 750 mg/m2 and vincristine 1.4 mg/m2 (maximum 2.0 mg) being given intravenously on day 1 and oral prednisolone 100 mg on days 1–5. The treatment was repeated every 3 weeks and this was continued for six or eight cycles. Forty-two patients were enrolled from 13 institutes in Korea. Among them, two patients were dropped after the first and second cycles of chemotherapy, respectively, without evaluation. The 40 patients received a total of 287 cycles of R-CVP c... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5227228 Thu, 15 Sep 2011 15:50:34 +0100 5227228 http://www.medworm.com/index.php?rid=5227229&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff3844816p1q50620%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1323-zAuthors Brian Quigley, Department of Pathology and Cell Biology, University of South Florida College of Medicine, 4105 W Coachman Ave, Tampa, FL 33611, USADeniz Peker, Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USALing Zhang, Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5227229 Tue, 13 Sep 2011 15:44:37 +0100 5227229 http://www.medworm.com/index.php?rid=5227230&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx47xh8w3nq8m6x47%2F Abstract  The absence of researches about autophagy in multiple myeloma promoted us to explore the biological characteristics and role of autophagy induced by nutrient depletion in multiple myeloma (MM) cell line RPMI8226 cells. Both autophagic and apoptotic morphology were observed by TUNEL, transmission electron microscopy (TEM), and monodansylcadervarine (MDC) staining. MDC staining fluorescent intensity and the conversion of LC3-I to LC3-II demonstrated autophagy increased time-dependently at 6, 12, and 18 h then declined at 24 and 48 h. FCM analysis of Annexin V-FITC/PI (AV/PI) dual staining and TUNEL assay demonstrated apoptosis increased time-dependently at 6, 12, 18, 24, and 48 h, and it burst at 24 h when autophagy declined. Bax translocation fro... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5227230 Tue, 13 Sep 2011 15:44:36 +0100 5227230 http://www.medworm.com/index.php?rid=5227231&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2828726444545613%2F This study aimed to investigate if cytomegalovirus infection contributes to the development of VTE in immunocompetent individuals. CMV-IgG and CMV-IgM antibody titres, CMV-IgG avidity and CMV-DNA were identified in samples from 166 VTE patients and from 166 healthy blood donors matched for gender and age. CMV-IgG antibodies were found more frequently in VTE patients compared to controls [57.8% vs. 44.0%; adjusted OR 1.75 (95% CI 1.13–2.70); p = 0.016]. Accordingly, median CMV-IgG titres were significantly higher in the case group (89.4 vs. 1.8 AU/ml; p = 0.002). Although the overall rate was low, CMV-IgM antibodies were detected more often among cases than controls. The difference was significant in patients with an unprovoked VTE event [7.4% vs. 0.6%; adjusted OR 5.26 ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5227231 Mon, 12 Sep 2011 15:53:00 +0100 5227231 http://www.medworm.com/index.php?rid=5210165&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm131758k86q23m51%2F This study investigated the association of DAAM2 genetic polymorphism with the clinical outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). We selected candidate single nucleotide polymorphisms (SNPs) by DNA chip analysis using Illumina Infinium Human-1 microarrays™ on 15 patients who underwent allogeneic HSCT with (N = 7) or without (N = 8) acute graft versus host disease (GvHD). Six SNPs (rs2504787, rs2504086, rs2504082, rs3004067, rs882559, and rs3004070) of DAAM2 were associated with acute GvHD prevalence, and the genotyping was extended to larger population (N = 228). Medical records were reviewed to see the correlation of these SNPs with the clinical outcomes of the patients. In rs2504082 and rs882559, treatment-related mortality was significantl... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210165 Fri, 09 Sep 2011 16:46:49 +0100 5210165 http://www.medworm.com/index.php?rid=5210164&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6354h28453080n03%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1333-xAuthors Tomonori Nakazato, Department of Hematology, Yokohama Municipal Citizen’s Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555 JapanYukinari Sanada, Department of Hematology, Yokohama Municipal Citizen’s Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555 JapanAi Mihara, Department of Hematology, Yokohama Municipal Citizen’s Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555 JapanChisako Ito, Department of Hematology, Yokohama Municipal Citizen’s Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555 JapanYoshinobu Aisa, Department of Hematology, Yokohama Municipal Citizen’s Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555 JapanNaoya Nakamura, D... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210164 Fri, 09 Sep 2011 16:46:49 +0100 5210164 http://www.medworm.com/index.php?rid=5210166&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1542qj12j986441u%2F In conclusion, TET2 and ASXL1 pathogenic mutations are found in 8% of MPN lacking JAK2 and MPL mutations, whereas IDH1, IDH2, and c-CBL mutations are not detected in this subset of patients. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00277-011-1330-0Authors Luz Martínez-Avilés, Department of Pathology, Hospital del Mar, Barcelona, SpainCarlos Besses, Department of Clinical Hematology, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, SpainAlberto Álvarez-Larrán, Department of Clinical Hematology, Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, SpainErica Torres, Department of Pathology, Hospital del Mar, Barcelona, SpainSergi Serrano, Department of Pathology, Hospital del Mar, Barcelona, SpainBeatriz Bellosillo, Department of P... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210166 Fri, 09 Sep 2011 05:49:56 +0100 5210166 http://www.medworm.com/index.php?rid=5210167&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn553312565763335%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1322-0Authors Joyeeta Bhattacharyya, Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553 JapanKeichiro Mihara, Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553 JapanYoshihiro Takihara, Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553 JapanAkiro Kimura, Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasum... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210167 Thu, 08 Sep 2011 06:09:28 +0100 5210167 http://www.medworm.com/index.php?rid=5210171&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl10vu46118307673%2F Abstract  Thal–dex (TD) is an effective therapy for advanced MM. We evaluated TD as salvage treatment of MM patients at first relapse. Thal was given at a daily dose of 100 or 200 mg until progression. Dex was administered 160 mg/month. One hundred patients were enrolled. First line therapy included ASCT (72%) and conventional CHT (28%). Fifty-nine percent received a fixed thal dose of 100 mg/day. The most frequent adverse events were constipation (42%), peripheral neuropathy (58%, 5% grade 3), bradycardia (20%), skin rash (11%), and VTE (7%). Discontinuation of thal due to adverse events was recorded in eight patients. On ITT, 46% of patients achieved at least a PR. Median DOR was 28 months, median time to next therapy was 15.5 months. Median OS, ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210171 Thu, 08 Sep 2011 06:09:27 +0100 5210171 http://www.medworm.com/index.php?rid=5210170&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvh8718wu4r23r2k6%2F In this study, we investigated Ras pathway mutations and prognostic implication in Korean patients with JMML. A total of 22 Korean patients with JMML were recruited from two institutions (19 boys and three girls; median age, 17 months; range, 1–74 months). Hematologic and cytogenetic findings were reviewed. Mutation analyses involved PTPN11, KRAS, NRAS, and CBL genes by direct sequencing analyses (selected exons except in CBL). Survival analysis was performed by the Kaplan–Meier method. Cytogenetic and/or gene mutations were detected in 18 patients out of 22 (82%). Four patients (18%) had chromosomal abnormalities, with monosomy 7 being the most common. Seventeen (77%) had gene mutations. PTPN11 mutations were detected in 13 patients (59%). The patient heterozygous for c... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210170 Thu, 08 Sep 2011 06:09:27 +0100 5210170 http://www.medworm.com/index.php?rid=5210169&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd43716877hrm449t%2F This article highlights the aspects of sickle cell nephropathy pathophysiology and clinical manifestations and describes the most recent advances in the diagnosis and treatment of this disorder. Content Type Journal ArticleCategory Review ArticlePages 1-9DOI 10.1007/s00277-011-1327-8Authors Geraldo Bezerra da Silva Junior, Post-Graduation Program in Medical Sciences, Department of Internal Medicine, Federal University of Ceará, Rua Vicente Linhares, 1198, CEP 60135-270 Fortaleza, Ceará, BrazilAlexandre Braga Libório, Medicine School, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, BrazilElizabeth De Francesco Daher, Post-Graduation Program in Medical Sciences, Department of Internal Medicine, Federal University of Ceará, Rua Vicente Linhares, 1198, CEP 60135... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210169 Thu, 08 Sep 2011 06:09:27 +0100 5210169 http://www.medworm.com/index.php?rid=5210168&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmn60235813714m36%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1336-7Authors Nils Milman, Department of Clinical Biochemistry, Næstved Hospital, Ringstedgade 61, 4700 Næstved, Denmark Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210168 Thu, 08 Sep 2011 06:09:27 +0100 5210168 http://www.medworm.com/index.php?rid=5210175&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F201781k777540312%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1328-7Authors Jui-Ting Yu, Division of Hematology/Oncology, Department of Medicine, Taichung Veterans General Hospital, 160, Section 3, Chungkang Road, Taichung, 407 TaiwanWen-Li Hwang, Division of Hematology/Oncology, Department of Medicine, Taichung Veterans General Hospital, 160, Section 3, Chungkang Road, Taichung, 407 TaiwanRen-Ching Wang, Department of Pathology, Taichung Veterans General Hospital, Taichung, TaiwanChieh-Lin Teng, Division of Hematology/Oncology, Department of Medicine, Taichung Veterans General Hospital, 160, Section 3, Chungkang Road, Taichung, 407 Taiwan Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210175 Mon, 05 Sep 2011 16:13:41 +0100 5210175 http://www.medworm.com/index.php?rid=5210174&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftm74242224456303%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1324-yAuthors Nahla M. Heikal, Department of Pathology, University of Utah and ARUP Reference Laboratory, Salt Lake City, UT, USAShashirekha Shetty, Department of Pathology, Cleveland Clinic Foundation, 9500 Euclid Ave. L23, Cleveland, OH 44195, USA Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210174 Mon, 05 Sep 2011 16:13:41 +0100 5210174 http://www.medworm.com/index.php?rid=5210173&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F367788n45807j7v2%2F This study is the first one demonstrating the early change in sIL-17 during the peri-transplant period and the association with early relapse in humans. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s00277-011-1318-9Authors Byung-Sik Cho, Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, #505 Banpo-dong, Seocho-gu, Seoul 137-701, South KoreaJi-Young Lim, Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, #505 Banpo-dong, Seocho-gu, Seoul 137-701, South KoreaSeung-Ah Yahng, Department of Hematology, Catholic Blood and Marrow Transplantatio... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210173 Mon, 05 Sep 2011 16:13:41 +0100 5210173 http://www.medworm.com/index.php?rid=5210172&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb6868j1520kk7765%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1329-6Authors Anselm Chi-wai Lee, Children’s Haematology and Cancer Centre, Mount Elizabeth Hospital, Level 4, 3 Mount Elizabeth, Singapore, 228510 SingaporeChee Meng Fong, Parkway Laboratory Services, Mount Elizabeth Hospital, Singapore, Singapore Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210172 Mon, 05 Sep 2011 16:13:41 +0100 5210172 http://www.medworm.com/index.php?rid=5210176&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F14867j818240834p%2F Abstract  This prospective multicenter study was performed to clarify the efficacy and safety of micafungin (MCFG) as an empirical antifungal therapy for suspected fungal infection in patients with hematological disorders and neutropenia. Three hundred and eighty-eight patients were enrolled; 151 patients with possible fungal infection diagnosed by radiological imaging or serological testing and 237 patients with refractory fever were included in this study. The mean dose and duration of treatment with MCFG were 154.6 mg/day and 14.0 days, respectively. The clinical response rate for patients with possible fungal infection and refractory fever was 60.1% and 65.3%, respectively. Even in persistent neutropenic patients with a neutrophil count of <500/μL throughou... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5210176 Mon, 05 Sep 2011 16:13:39 +0100 5210176 http://www.medworm.com/index.php?rid=5184964&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb124752404t76l15%2F Abstract  CD4+ T cells play a crucial role in the pathogenesis of acquired aplastic anemia (AA). Tcf-1 gene regulates T cell development and function, and it is significantly upregulated in the bone marrow CD4+ T cells from patients with acquired AA. To explore the role of Tcf-1 in the pathogenesis of AA, we knocked down Tcf-1 gene in CD4+ T cells of AA patients and studied the effects of Tcf-1 silencing on its downstream gene expression. Upon transfection of psiRNA into marrow CD4+ T cells from bone marrow of aplastic anemia patients, the expression of Tcf-1 was significantly knocked down; consequently, expressions of c-Myc and CD44 were also significantly reduced. Our results suggest that Tcf-1 may contribute to pathogenesis of AA by regulating downstream gene expression s... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5184964 Wed, 31 Aug 2011 15:53:14 +0100 5184964 http://www.medworm.com/index.php?rid=5184963&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkt2511k038kh0q7j%2F In conclusion, this novel group of compounds shows differential inhibition patterns with regard to FLT3 kinase and displays a promising profile for further clinical development. Currently, experiments evaluating toxicity in murine models and unraveling the exact binding mechanism are under way to facilitate a potential clinical application. Content Type Journal ArticleCategory Original ArticlePages 1-14DOI 10.1007/s00277-011-1311-3Authors Florian H. Heidel, Department of Hematology and Oncology, Medical Center, Otto-von-Guericke University, Leipzigerstr. 44, 39120 Magdeburg, GermanyThomas S. Mack, Department of Hematology and Oncology, Medical Center, Otto-von-Guericke University, Leipzigerstr. 44, 39120 Magdeburg, GermanyElena Razumovskaya, Experimental Clinical Chemistry, Wallen... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5184963 Wed, 31 Aug 2011 15:53:14 +0100 5184963 http://www.medworm.com/index.php?rid=5184965&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft2063736ww57x518%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1312-2Authors Xenofon Papanikolaou, “Henry Dunant” General Hospital, Athens, GreeceMaria Kotsopoulou, “Metaxa” Specialized Anticancer Hospital of Piraeus, Piraeus, GreeceI. Diana Triantafillopoulou, “Metaxa” Specialized Anticancer Hospital of Piraeus, Piraeus, GreeceAthanasia Zoi, Biomedical Research Institute of Academy of Athens, Athens, GreeceVasilis Chatziantoniou, “Metaxa” Specialized Anticancer Hospital of Piraeus, Piraeus, GreeceDimitrios Maltezas, “Metaxa” Specialized Anticancer Hospital of Piraeus, Piraeus, GreeceChrysanthi Mitsouli-Mentzikof, “Metaxa” Specialized Anticancer Hospital of Piraeus, Piraeus, Greece Journal Annals of HematologyOnline ISSN 1432-058... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5184965 Wed, 31 Aug 2011 15:53:12 +0100 5184965 http://www.medworm.com/index.php?rid=5184966&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F257v2v5606854625%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s00277-011-1313-1Authors Man Fai Law, Department of Medicine, Tuen Mun Hospital, Hong Kong, ChinaWai Lun Poon, Department of Radiology, Tuen Mun Hospital, Hong Kong, ChinaKwan Shun Ng, Department of Pathology, Tuen Mun Hospital, Hong Kong, ChinaHay Nun Chan, Department of Medicine, Tuen Mun Hospital, Hong Kong, ChinaHo Kei Lai, Department of Medicine, Tuen Mun Hospital, Hong Kong, ChinaChun Yin Ha, Department of Medicine, Tuen Mun Hospital, Hong Kong, ChinaCelia Ng, Department of Medicine, Tuen Mun Hospital, Hong Kong, ChinaYiu Ming Yeung, Department of Medicine, Tuen Mun Hospital, Hong Kong, ChinaSze Fai Yip, Department of Medicine, Tuen Mun Hospital, Hong Kong, China Journal Annals of HematologyOnlin... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5184966 Wed, 31 Aug 2011 15:53:11 +0100 5184966 http://www.medworm.com/index.php?rid=5163474&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F43rh22k13tp87155%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00277-011-1301-5Authors Su-Xia Li, Department of Geriatric Hematology, Chinese People’s Liberation Army General Hospital, Beijing, 100853 ChinaHong-Li Zhu, Department of Geriatric Hematology, Chinese People’s Liberation Army General Hospital, Beijing, 100853 ChinaBo Guo, Department of Geriatric Hematology, Chinese People’s Liberation Army General Hospital, Beijing, 100853 ChinaXue-Chun Lu, Department of Geriatric Hematology, Chinese People’s Liberation Army General Hospital, Beijing, 100853 ChinaBo Yang, Department of Geriatric Hematology, Chinese People’s Liberation Army General Hospital, Beijing, 100853 ChinaYang Liu, Department of Geriatric Hematology, Chinese People’s Liberation Army General ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5163474 Fri, 19 Aug 2011 05:50:57 +0100 5163474 http://www.medworm.com/index.php?rid=5163475&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc4mk66g12ptq48p8%2F Abstract  Anthracyclines are a major component in the therapy of non-Hodgkin's lymphoma. However, due to their cardiac toxicity potential, curative and palliative treatment is often limited in patients with preexisting cardiac dysfunction. Liposomal doxorubicin formulations have been described to be less cardiotoxic than conventional doxorubicin. In the current study, we analyzed the efficacy and toxicity of pegylated liposomal doxorubicin (PLD) as constituent of the cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen replacing conventional doxorubicin in 21 patients with impaired cardiac left ventricular ejection fraction or preexisting cardiac risk factors and established diagnosis of diffuse large B cell lymphoma (n = 15), mantle cell lymphoma (n... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5163475 Thu, 18 Aug 2011 06:02:36 +0100 5163475 http://www.medworm.com/index.php?rid=5163476&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F84qtu87q8vng16jr%2F Another Hb with inclusion bodies β-thalassemia, owing to Hb Durham-N.C. [β114(G16) Leu > Pro]. First case described in Hispanic populations Content Type Journal ArticleCategory Letter to the EditorPages 1-4DOI 10.1007/s00277-011-1310-4Authors Paloma Ropero, Servicio de Hematología, Hospital Clínico San Carlos, C/Profesor Martín Lagos s/n, 28040 Madrid, SpainRaúl Córdoba, Servicio de Hematología, Hospital Infanta Sofía, Madrid, SpainMarta Morado, Servicio de Hematología, Hospital Universitario La Paz, Madrid, SpainFernando Ataulfo González, Servicio de Hematología, Hospital Clínico San Carlos, C/Profesor Martín Lagos s/n, 28040 Madrid, SpainAna Villegas, Servicio de Hematología, Hospital Clínico San Carlos, C/Profesor Martín Lagos s/n, 28040 Madrid, SpainErythropathology... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5163476 Tue, 16 Aug 2011 06:18:50 +0100 5163476 http://www.medworm.com/index.php?rid=5120506&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnl5v6706k50g8127%2F Abstract  Nutritional status is an independent prognostic factor in immunoglobulin light-chain amyloidosis (AL), but its influence on quality of life (QoL) is unknown. The aim of this cross-sectional study was to investigate the association between nutritional status and QoL in AL patients at diagnosis. One hundred and fifty consecutive patients with biopsy-proven AL were assessed for nutritional status by anthropometry [body mass index, unintentional weight loss (WL) in the previous 6 months and mid-arm muscle circumference (MAMC)], biochemistry (serum prealbumin), and semiquantitative food intake at referral. QoL was assessed by the Medical Outcomes Study 36-item Short Form General Health Survey. The composite physical component summary (PCS) and the mental component... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5120506 Mon, 08 Aug 2011 19:53:16 +0100 5120506 http://www.medworm.com/index.php?rid=5110575&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F420j331154265n80%2F Abstract  Primary gastric diffuse large B cell lymphoma (PG-DLBCL) is common subtype of extranodal non-Hodgkin lymphoma. The optimal treatment strategy for PG-DLBCL in the rituximab era still remains unknown. To evaluate clinical outcomes of PG-DLBCL in the rituximab era, we conducted a retrospective, multicenter analysis of 95 patients with PG-DLBCL. In 58 patients with localized disease, 3-year progression-free survival (PFS) and overall survival (OS) were 91% and 91% for patients with six cycles of rituximab plus CHOP (R-CHOP) and 92% and 95% for patients with three to four cycles of R-CHOP plus radiotherapy (Log-rank test, P = 0.595 and P = 0.278, respectively). In 37 patients with advanced disease, 3-year PFS and 3-year OS were 43% and 64% for patients with R-C... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5110575 Sat, 06 Aug 2011 05:45:12 +0100 5110575 http://www.medworm.com/index.php?rid=5110576&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb238h05818q76123%2F In this study, we established a quantitative methodology to assess EPC function by using an in vitro 5-(6)-carboxyfluorescein diacetate succinimidyl ester-labeling vessel formation assay. The EPCs were cultured in three different glucose concentrations (100, 189.5, and 295.5 mg/dl of d-glucose) representing normal control and diabetes with either good or poor glycemic control, respectively. We found that the in vitro vessel-forming capacity was impaired in EPCs cultured in high glucose concentrations compared to normal control (43.4 ± 0.8% and 34.7 ± 0.7% vs. 50.8 ± 2.1%). We further studied expression of various genes involved in vessel formation. There was a lower level of angiopoietin 1 gene expression in EPCs cultured in high glucose concentrations. The additio... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5110576 Sat, 06 Aug 2011 05:45:11 +0100 5110576 http://www.medworm.com/index.php?rid=5098730&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8333w5tv92k5w286%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00277-011-1307-zAuthors Seah H. Lim, Texas Oncology-Amarillo Cancer Center, Amarillo, TX, USASrinivas Pathapati, Texas Oncology-Amarillo Cancer Center, Amarillo, TX, USAJames Langevin, Texas Oncology-Amarillo Cancer Center, Amarillo, TX, USAAndrew Hoot, Texas Oncology-Amarillo Cancer Center, Amarillo, TX, USA Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5098730 Tue, 02 Aug 2011 15:52:11 +0100 5098730 http://www.medworm.com/index.php?rid=5098731&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpr01837861mr6568%2F Abstract  Early relapse is a parameter that affects clinical outcomes in relapsed diffuse large B cell lymphoma (DLBCL). The prognostic value of lymphopenia following the completion of first-line therapy and the relationship between lymphopenia and early relapse are unknown. Therefore, we studied the role of absolute lymphocyte count (ALC) on early relapse. We retrospectively analyzed de novo DLBCL patients who were treated with rituximab-containing treatment between 2003 and 2010. The median age at the time of diagnosis of 59 DLBCL patients was 71 years. We identified no association between ALC at diagnosis and ALC following the completion of first-line therapy. Among all patients analyzed, 13 (22%) patients were confirmed to exhibit early relapse. Low ALC following t... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5098731 Tue, 02 Aug 2011 15:52:08 +0100 5098731 http://www.medworm.com/index.php?rid=5098732&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F808872172p64246x%2F In conclusion, arterial dysfunction found in patients with beta-thalassaemia major before and after HSCT may be related to impaired proliferation of CD133+VEGFR2+ and CD34+VEGFR2+ cells. Content Type Journal ArticlePages 1-8DOI 10.1007/s00277-011-1302-4Authors Yiu-fai Cheung, Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, 102, Pokfulam Road, Hong Kong, ChinaShing Chan, Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, 102, Pokfulam Road, Hong Kong, ChinaMo Yang, Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, 102, Pokfulam ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5098732 Tue, 02 Aug 2011 06:17:12 +0100 5098732 http://www.medworm.com/index.php?rid=5098733&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp73vl34243l522j3%2F In this study, we explored the origin of UCB-derived EPCs by culturing CD14+ or CD14− subpopulation separately and co-culturing these two subpopulations either with or without transwells. We found no colony formation with CD14+ or CD14− subpopulation alone, but there were EPC colonies observed in direct co-cultures of both subpopulations. Transwell culture system was used to further study the effect of cytokines on EPC colony formation. We observed the presence of EPC colonies derived from CD14− subpopulation in the presence of CD14+ subpopulation in the upper compartment whereas there was no colony generated from CD14+ subpopulation with CD14− subpopulation in the upper compartment. Therefore, CD14− subpopulation is likely to be the origin of EPCs and EPC colony derivation... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5098733 Tue, 02 Aug 2011 06:17:11 +0100 5098733 http://www.medworm.com/index.php?rid=5089150&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqp2717m347314133%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00277-011-1304-2Authors Leonie A. Boven, Department of Clinical Chemistry, Meander Medical Centre, Utrechtseweg 160, 3818 ES Amersfoort, The NetherlandsAmy de Haar-Holleman, Department of Hematology, Meander Medical Centre, Amersfoort, The NetherlandsClaudia C. Folman, Sanquin Diagnostics, Amsterdam, The NetherlandsRob J. Kraaijenhagen, Department of Clinical Chemistry, Meander Medical Centre, Utrechtseweg 160, 3818 ES Amersfoort, The NetherlandsRob Fijnheer, Department of Hematology, Meander Medical Centre, Amersfoort, The Netherlands Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5089150 Fri, 29 Jul 2011 16:05:56 +0100 5089150 http://www.medworm.com/index.php?rid=5080862&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6g61w02555v55252%2F Abstract  Controversy remains regarding the transplant outcomes of human leukocyte antigen-identical related bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) for the treatment of patients with hematological malignancies. To provide an estimate of the effect of BMT and PBSCT on clinical outcomes in patients with hematological malignancies, we conducted a meta-analysis based on time-to-event data from 17 randomized controlled trials. PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL), from 1972 through July 2010, and conference proceedings through July 2009 and reference lists, without any language restriction, of randomized trials that compared the transplant outcomes after BMT and PBSCT in patients with hemat... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5080862 Tue, 26 Jul 2011 05:51:26 +0100 5080862 http://www.medworm.com/index.php?rid=5080863&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd616822m4n16625m%2F Abstract  We determined the prevalence and progression rate of monoclonal gammopathy of undetermined significance (MGUS) and light-chain MGUS (LCMGUS) in Germany utilizing the biobank of the population-based Heinz Nixdorf Recall Study. The Heinz Nixdorf Recall Study comprises 4,814 men and women aged 45–75 years. To detect monoclonal proteins, standard serum electrophoresis was combined with parallel screening immunofixation using pentavalent antisera. Additionally, free light chains (FLC) were measured in all samples. Definition of MGUS included M-protein concentration, laboratory results, and disease history. LCMGUS was defined as abnormal FLC ratio, increase in FLC causing the abnormal ratio, and lack of intact immunoglobulin. One hundred sixty-five MGUS cases wer... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5080863 Tue, 26 Jul 2011 05:51:24 +0100 5080863 http://www.medworm.com/index.php?rid=5080864&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F54206p754574t658%2F In conclusion, sequential VAD and VTD induction therapy in patients with newly diagnosed multiple myeloma was active with manageable toxicity and excellent stem cell yields. The incorporation of bortezomib as a consolidation therapy improved the clinical outcome with the expense of rather frequent development of peripheral neuropathy. Content Type Journal ArticlePages 1-8DOI 10.1007/s00277-011-1298-9Authors Hye Jin Kim, The Armed Forces Capital Hospital, Seoul, South KoreaSung-Soo Yoon, Clinical Research Institute, Seoul National University College of Medicine, Seoul, South KoreaDong Soon Lee, Clinical Research Institute, Seoul National University College of Medicine, Seoul, South KoreaSang Kyun Sohn, Kyungbook National University Hospital, Daegu, South KoreaHyeon Seok Eom, Natio... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5080864 Tue, 26 Jul 2011 05:51:23 +0100 5080864 http://www.medworm.com/index.php?rid=5070560&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmr51l71055406n81%2F Abstract  Ethnic and regional differences in the epidemiology and pathological aspects of Hodgkin’s lymphoma (HL) between Western and Asian patients may be associated with differences in clinical features and prognosis. We retrospectively analyzed the clinical and histopathological characteristics, therapeutic outcomes, and prognostic factors of 539 HL patients treated at 16 centers in Korea. We found that the incidence of histological subtypes of HL in Korea was similar to that in Western and other Asian countries. However, the incidence peaked between 16 and 30 years of age, unlike the bimodal age distribution seen in Western countries. In patients with stage I–IIA non-bulky disease, the complete response (CR) rate was similar between combined modality therapy an... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5070560 Mon, 25 Jul 2011 15:47:54 +0100 5070560 http://www.medworm.com/index.php?rid=5064322&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F832852gpk438v615%2F In conclusion, B-cells are increased in the red pulp of the spleen and together with cytotoxic T-cells, helper T-cells and macrophages line the sinusoids enabling the immunological attack on platelets in ITP. Content Type Journal ArticlePages 1-7DOI 10.1007/s00277-011-1292-2Authors Bob Olsson, Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, SwedenBörje Ridell, Department of Pathology the Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenMargareta Jernås, Department of Internal Medicine the Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenHans Wadenvik, Department of Internal Medicine the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Journal Annals of HematologyOnline ISSN 1432-0584Print IS... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5064322 Fri, 22 Jul 2011 17:06:27 +0100 5064322 http://www.medworm.com/index.php?rid=5064323&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcu840g6v1kl8471r%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00277-011-1296-yAuthors Eswar Tipirneni, St.Vincent Hospital, Internal Medicine, Worcester, MA, USAAmanpreet Buttar, Department of Hematology/Oncology, UMASS Memorial Medical Center, Worcester, MA, USADoreen Brettler, Department of Hematology, UMASS Memorial Medical Center, Worcester, MA, USAPatricia Miron, Department of Cytogenetics, UMASS Memorial Medical Center, Worcester, MA, USAVenu Bathini, Department of Hematology/Oncology, UMASS Memorial Medical Center, Worcester, MA, USA Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5064323 Thu, 21 Jul 2011 18:15:35 +0100 5064323 http://www.medworm.com/index.php?rid=5064324&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk050gjv2t0h8870w%2F Content Type Journal ArticlePages 1-4DOI 10.1007/s00277-011-1295-zAuthors Miguel Martín Abelleyro, Departamento de Genética, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina de Buenos Aires, Pacheco de Melo 3081, Buenos Aires, 1425 ArgentinaLiliana Carmen Rossetti, Departamento de Genética, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina de Buenos Aires, Pacheco de Melo 3081, Buenos Aires, 1425 ArgentinaClaudia Pamela Radic, Departamento de Genética, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina de Buenos Aires, Pacheco de Melo 3081, Buenos Aires, 1425 ArgentinaMiguel Candela, Departamento de Hemoterapia y Hemofilia, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina de Buenos ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5064324 Tue, 19 Jul 2011 23:38:13 +0100 5064324 http://www.medworm.com/index.php?rid=5064325&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb2520555671327x4%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00277-011-1294-0Authors Irene Dy, Department of Hematology and Oncology, St. Luke’s Roosevelt Hospital, 1000 Tenth Avenue 11G, New York, NY, USAVenkata Pokuri, Department of Internal Medicine, St. Luke’s Roosevelt Hospital, 1000 Tenth Avenue 11G, New York, NY, USAJohn Olichney, Department of Hematology and Oncology, St. Luke’s Roosevelt Hospital, 1000 Tenth Avenue 11G, New York, NY, USAPeter Wiernik, Department of Hematology and Oncology, St. Luke’s Roosevelt Hospital, 1000 Tenth Avenue 11G, New York, NY, USA Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5064325 Tue, 19 Jul 2011 23:38:12 +0100 5064325 http://www.medworm.com/index.php?rid=5031317&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl3568145q4q4h231%2F Abstract  Covert brain infarction is an emerging concern in patients with β-thalassemia intermedia (TI). We have recently observed a high prevalence (60%) of silent brain infarction on brain magnetic resonance imaging (MRI) in 30 splenectomized adults with TI. In this work, we further evaluate cerebral involvement in the same 30 patients using fluorodeoxyglucose positron emission tomography–computed tomography (PET-CT) scanning. The median age was 32 years (range, 18–54 years) with a male to female ratio of 13:17. Nineteen patients (63.3%) had evidence of decreased neuronal function on PET-CT. Involvement was mostly left sided, multiple, and most commonly in the temporal and parietal lobes. Elevated liver iron concentration, beyond 15 mg Fe/g dry weight, ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5031317 Wed, 13 Jul 2011 06:17:34 +0100 5031317 http://www.medworm.com/index.php?rid=5021755&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft3224373p4x38746%2F This study performed on the largest cohort of MDS patients with ider(20q) is the first that identifies specific morphological features (hypogranulated and vacuolized neutrophils and neutrophil erythrophagocytosis) allowing the identification of this cytogenetic abnormality with high sensitivity (70%) and specificity (85.7%). Suspected ider(20q) by morphology should therefore support targeted FISH tests in case of non informative karyotype. This combined approach will allow a better estimation of the prevalence of this underdiagnozed entity. The overall survival and progression-free survival did not statistically differ in both groups. However, hypogranulated and vacuolized neutrophils were significantly associated with survival. Content Type Journal ArticlePages 1-11DOI 10.1007/... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5021755 Sat, 09 Jul 2011 06:16:55 +0100 5021755 http://www.medworm.com/index.php?rid=5021756&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa6753166t397lq64%2F Abstract  Prognosis of AML in elderly patients is poor due to adverse patient characteristics and comorbidities. In addition, disease-associated parameters reveal differences between older and younger patients with AML. Survival in normal karyotype AML (NK-AML) is influenced by different clinical and molecular markers. The aim of this work was to investigate the frequencies of molecular markers in patients with NK-AML with a focus on NPM1 mutations and FLT3-ITD in different age groups. In the present study, we analyzed the frequencies of mutations of NPM1 and FLT3-ITD in a cohort of 1,321 adult patients and 148 children with AML treated within the AMLCG99, the AML98, and AML04 trials and their distribution in different age groups. Additionally, the frequencies of mutations in... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5021756 Sat, 09 Jul 2011 06:16:54 +0100 5021756 http://www.medworm.com/index.php?rid=5010599&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl864959t8j3jl178%2F Content Type Journal ArticlePages 1-3DOI 10.1007/s00277-011-1284-2Authors David Coffey, Department of Medicine, University of Colorado Denver, 12631 East 17th Avenue, #B177, P.O. Box 6511, Aurora, CO 80045, USABrandon Fain, School of Medicine, University of Colorado Denver, Aurora, CO, USAChristopher Thompson, Division of Hematology-Oncology, University of Colorado Denver, Aurora, CO, USAEdward D. Chan, Department of Medicine, University of Colorado Denver, 12631 East 17th Avenue, #B177, P.O. Box 6511, Aurora, CO 80045, USASamia Nawaz, Department of Pathology, University of Colorado Denver and Veteran Affairs Medical Center, Aurora, CO, USA Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5010599 Wed, 06 Jul 2011 05:55:40 +0100 5010599 http://www.medworm.com/index.php?rid=5010600&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F35p6l445qg175054%2F Abstract  The aim of the study was to analyze and compare the functional properties and the gene expression profile of regulatory T cells (Tregs) isolated from cord blood (CB) units (n = 23) and from the peripheral blood (PB) of adult normal donors (n = 13). Tregs were purified from mononuclear cells and expanded for 6 days with anti-CD3, anti-CD28, and IL-2. CB and PB Tregs presented similar immunophenotypic features. However, Tregs isolated from CB presented a much higher expansion capacity; this was confirmed by the genomic characterization that showed in CB-derived Tregs significant enrichments of genes involved in cell proliferation, chromatin modification, and regulation of gene expression. All samples were positive for the FoxP3 gene and protein after exp... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5010600 Wed, 06 Jul 2011 05:55:39 +0100 5010600 http://www.medworm.com/index.php?rid=5000053&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2nr3940832786552%2F Abstract  Despite the advantage observed with novel drugs such as bortezomib, thalidomide, or lenalidomide, multiple myeloma (MM) remains incurable and there is a clear need for new drugs or combinations based on the pathogenetic mechanism of MM. One of the proposed mechanisms in MM pathogenesis is the involvement of kinase molecules in the growth and survival of myelomatous cells. In this study, we have explored the optimal combination for dasatinib, a tyrosine kinase inhibitor, in MM cells. A clear synergistic effect was observed with the triple combination of dasatinib with bortezomib and dexamethasone which was evident even in the presence of bone marrow microenvironment. Experiments performed on freshly isolated patients’ cells also demonstrated potentiation of respo... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5000053 Thu, 30 Jun 2011 09:38:42 +0100 5000053 http://www.medworm.com/index.php?rid=5000054&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh3406uu84w5265r4%2F Content Type Journal ArticlePages 1-3DOI 10.1007/s00277-011-1290-4Authors Yasuhiro Maeda, Department of Hematology, National Hospital Organization Osaka Minami Medical Center, 2-1, Kidohigashi, Kawachinagano, Osaka, 586-8521 JapanMasaya Kawauchi, Department of Hematology, National Hospital Organization Osaka Minami Medical Center, 2-1, Kidohigashi, Kawachinagano, Osaka, 586-8521 JapanJun-ichi Miyatake, Department of Hematology, National Hospital Organization Osaka Minami Medical Center, 2-1, Kidohigashi, Kawachinagano, Osaka, 586-8521 JapanChikara Hirase, Department of Hematology, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka, 589-8511 JapanTerufumi Yamaguchi, Department of Hematology, Kinki University School of Medicine, 377-2, Ohno-Higashi, Osaka, 589-8511 JapanItar... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5000054 Thu, 30 Jun 2011 09:38:41 +0100 5000054 http://www.medworm.com/index.php?rid=5000055&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq2w277u36036t518%2F Abstract   SET-NUP214 rearrangement is a recently recognized recurrent chromosomal translocation mostly observed in T-ALL. In order to characterize this rare entity, we performed phenotypic and genetic characterization of SET-NUP214 rearrangement through an investigation of a series of 40 consecutive samples of adult T-ALL that was selected among 229 adult ALL cases during 4 years in a single institution. Four cases (10%) of SET-NUP214 translocation were identified in our study. In all cases, diagnosis of T-ALL was established according to the World Health Organization (WHO) classification, and clonal TCR rearrangements were found. The immunophenotypic markers were indicative of the precursor nature of T lymphoblasts, and they expressed one or both of the myeloid-associ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=5000055 Thu, 30 Jun 2011 09:38:39 +0100 5000055 http://www.medworm.com/index.php?rid=4994126&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F42u2g820u22g10jl%2F Abstract  Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy. Treatment of patients suffering from high-risk AML as defined by clinical parameters, cytogenetics, and/or molecular analyses is often unsuccessful. OSI-461 is a pro-apoptotic compound that has been proposed as a novel therapeutic option for patients suffering from solid tumors like prostate or colorectal carcinoma. But little is known about its anti-proliferative potential in AML. Hence, we treated bone marrow derived CD34+ selected blast cells from 20 AML patients and the five AML cell lines KG-1a, THP-1, HL-60, U-937, and MV4-11 with the physiologically achievable concentration of 1 μM OSI-461 or equal amounts of DMSO as a control. Following incubation with OSI-461, we found a consis... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4994126 Wed, 29 Jun 2011 10:51:05 +0100 4994126 http://www.medworm.com/index.php?rid=4994127&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F13874u2619406496%2F Abstract  Intensification of chemotherapy in adults with acute lymphoblastic leukemia (ALL) has improved outcome. The aim of this analysis was to evaluate outcome of patients treated with an intensive regimen based on that used in the German national trials, but adapted in order to enable treatment to be given mainly on an out-patient basis, once complete remission (CR) had been achieved. Between 2000 and 2007, 53 patients with Philadelphia chromosome-negative ALL (40 with B-ALL and 13, T-ALL) received treatment. CR was achieved in 47/53 (89%), with no significant difference in CR rate between B- and T-ALL. At a median follow-up of 6.3 years, 25 patients are alive, 23 (43%) in 1st CR, and 20 have relapsed. No patient died in CR due to treatment-related toxicity. At 5&n... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4994127 Tue, 28 Jun 2011 15:46:35 +0100 4994127 http://www.medworm.com/index.php?rid=4986978&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd321p73j1633gqk2%2F Abstract  This review provides a status on the definition, prevalence, causes, and consequences of anemia in women who have given childbirth, i.e., postpartum anemia. The diagnosis of iron deficiency anemia relies on a full blood count including hemoglobin, serum ferritin, and serum soluble transferrin receptor, which appear to be reliable indicators of anemia and iron status 1 week postpartum while serum transferrin saturation is an unreliable indicator several weeks after delivery. It is recommended that postpartum anemia should be defined by hemoglobin <110 g/L at 1 week postpartum and <120 g/L at 8 weeks postpartum. The major causes of postpartum anemia are prepartum anemia combined with acute bleeding anemia due blood losses at delivery. N... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4986978 Mon, 27 Jun 2011 17:50:54 +0100 4986978 http://www.medworm.com/index.php?rid=4986980&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb273r316072m0487%2F Abstract  We conducted a retrospective survey to assess prescription practice, response rates to rituximab, and the predictive indicators for a response to rituximab therapy in patients with primary or secondary immune thrombocytopenic purpura (ITP). Data were collected retrospectively from 40 consecutive patients with ITP attending our hospital: 29 (72.5%) had primary ITP and 11 (27.5%) had secondary ITP. Rituximab was given either as four weekly injections (375 mg/m2) or two injections of 1,000 mg given 2 weeks apart in 30 and 10 patients, respectively. The primary objective was to evaluate overall (OR) and complete response (CR) to rituximab therapy for ITP. OR was excellent and rapid and similar when secondary ITP was excluded from the analysis: OR was ach... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4986980 Mon, 27 Jun 2011 17:50:52 +0100 4986980 http://www.medworm.com/index.php?rid=4986979&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk663t53881g16678%2F This study evaluated the prognostic value of minimal residual disease (MRD) monitoring by four-color flow cytometry (FCM) in patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). MRD was examined with four-color FCM at different time points in 139 patients (including pediatric and adult patients) with ALL after allo-HSCT. Real-time quantitative polymerase chain reaction (RQ-PCR) was applied to evaluate the MRD of Philadelphia chromosome-positive ALL (Ph+ ALL) patients. Patients who were FCM-positive (FCM+) after transplantation had a lower event-free survival (EFS) of 0.54 and a higher cumulative incidence of relapse (CIR) of 0.54 compared to an EFS of 0.80 and a CIR of 0.08 in FCM-negative (FCM−) patients (EFS, ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4986979 Mon, 27 Jun 2011 17:50:52 +0100 4986979 http://www.medworm.com/index.php?rid=4971169&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx608217562467257%2F Abstract  The treatment of patients with multiple myeloma usually includes many drugs including thalidomide, lenalidomide and bortezomib. Lovastatin and other inhibitors of HMG-CoA reductase demonstrated to exhibit antineoplasmatic and proapoptotic properties in numerous in vitro studies involving myeloma cell lines. We treated 91 patients with relapsed or refractory multiple myeloma with thalidomide, dexamethasone and lovastatin (TDL group, 49 patients) or thalidomide and dexamethasone (TD group, 42 patients). A clinical response defined of at least 50% reduction of monoclonal band has been observed in 32% of TD patients and 44% of TDL patients. Prolongation of overall survival and progression-free survival in the TDL group as compared with the TD group has been documented... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4971169 Wed, 22 Jun 2011 16:03:50 +0100 4971169 http://www.medworm.com/index.php?rid=4971170&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F568m02n85806g352%2F This study was conducted as a prospective, multicenter trial to evaluate the efficacy and safety of micafungin as an empirical therapy for suspected invasive fungal infections (IFIs), including febrile neutropenia (FN), and to evaluate the usefulness of β-d-glucan (BG) and Aspergillus galactomannan (GM) antigen in patients with hematologic diseases. A total of 121 patients were enrolled and assessed for safety, and 119 were examined for clinical efficacy. The main underlying diseases were acute myeloid leukemia (38.0%), acute lymphoblastic leukemia (18.2%), and malignant lymphoma (18.2%). The median initial daily dose and duration of micafungin treatment were 150 mg/day and 13 days, respectively. The overall response rate for suspected IFIs (n = 119), based on four comp... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4971170 Tue, 21 Jun 2011 20:54:54 +0100 4971170 http://www.medworm.com/index.php?rid=4947054&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw4j0401n523720kx%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00277-011-1278-0Authors Irene Donnini, Haematology Unit and Bone Marrow Trasplantation Section, University of Florence and Careggi Hospital, Largo Brambilla 3, 50134 Florence, ItalyBarbara Scappini, Haematology Unit and Bone Marrow Trasplantation Section, University of Florence and Careggi Hospital, Largo Brambilla 3, 50134 Florence, ItalyStefano Guidi, Haematology Unit and Bone Marrow Trasplantation Section, University of Florence and Careggi Hospital, Largo Brambilla 3, 50134 Florence, ItalyGiovanni Longo, Haematology Unit and Bone Marrow Trasplantation Section, University of Florence and Careggi Hospital, Largo Brambilla 3, 50134 Florence, ItalyAlberto Bosi, Haematology Unit and Bone Marrow Trasplantation Section, University of Flore... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4947054 Fri, 17 Jun 2011 10:55:39 +0100 4947054 http://www.medworm.com/index.php?rid=4947055&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr51g001506jk0041%2F In conclusion, our study did not show a benefit for the use of peri-transplant IVIG (0.4 g/kg) to reduce infectious complications in a large cohort of patients with myeloma undergoing ASCT. In the absence of data supporting efficacy in this context, there appears to be no benefit in the routine use of IVIG for this purpose. Content Type Journal ArticlePages 1-6DOI 10.1007/s00277-011-1275-3Authors Piers Blombery, Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Melbourne, Victoria, AustraliaH. Miles Prince, Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Melbourne, Victoria, AustraliaLeon J. Worth, Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Melbourne, Victoria, AustraliaJo Main, Division o... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4947055 Wed, 15 Jun 2011 06:18:54 +0100 4947055 http://www.medworm.com/index.php?rid=4947056&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1184436g3w5k482q%2F In this study, we investigated the early alterations of hemostatic parameters in allogeneic HSCT recipients and determined their potential diagnostic values in transplantation-related thrombotic complications and other post-HSCT events. Results from 107 patients with allogeneic HSCT showed higher levels of plasma plasminogen activator inhibitor-1 (PAI-1), fibrinogen, and tissue-plasminogen activator (t-PA) and a lower level of plasma protein C after transplantation. No change was found for prothrombin time, antithrombin III, d-dimer, and activated partial thromboplastin time following HSCT. Transplantation-related complications (TRCs) in HSCT patients were defined as thrombotic (n = 8), acute graft-versus-host disease (aGVHD, n = 45), and infectious (n = 38). All patients ... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4947056 Wed, 15 Jun 2011 06:18:52 +0100 4947056 http://www.medworm.com/index.php?rid=4947057&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj45178523840818j%2F This study aimed to determine whether progress in developing bleeding risk estimation tools for patients on oral anticoagulant therapy has been made since 2006 when we last systematically reviewed this topic, and to refresh previously published quantitative evaluations of the clinical prediction rules (CPRs) available for estimating bleeding risk in patients on oral anticoagulant therapy. A systematic review of English language literature published since December 2006 was conducted when our previous systematic review ended. Studies were analyzed for predictive performance using likelihood ratios. Six studies detailed CPRs used to assess risk of bleeding prior to commencing warfarin therapy, four of which were included in the analysis. Three studies evaluated new CPRs (“RIETE” and... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4947057 Tue, 14 Jun 2011 05:54:58 +0100 4947057 http://www.medworm.com/index.php?rid=4947058&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa593781521150687%2F Abstract  Cancer survivors are at risk of experiencing adverse physical and psychosocial effects of their cancer and its treatment. Both Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) survivors face problems that can affect their health-related quality of life (HRQoL). The authors systematically reviewed the literature on HRQoL among HL and NHL survivors. A PubMed and PsychINFO literature search for original articles published until May 2011 was performed. Twenty-four articles, which met the predefined inclusion criteria, were subjected to a quality checklist. HL survivors showed the most problems in (role) physical, social and cognitive functioning, general health, fatigue and financial problems. In addition, HL survivors treated with a combination of therapi... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4947058 Tue, 14 Jun 2011 05:54:57 +0100 4947058 http://www.medworm.com/index.php?rid=4914697&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F05178547322727r4%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00277-011-1270-8Authors Tobias Goerge, Department of Dermatology, University Hospital Muenster, Muenster, GermanyGuenther Schellong, Department of Pediatric Hematology and Oncology, Childrens University Hospital Muenster, Muenster, GermanyRolf M. Mesters, Department of Medicine—Hematology and Oncology, University Hospital Muenster, Albert—Schweitzerstreet 33, 48149 Muenster, GermanyWolfgang E. Berdel, Department of Medicine—Hematology and Oncology, University Hospital Muenster, Albert—Schweitzerstreet 33, 48149 Muenster, Germany Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4914697 Mon, 06 Jun 2011 15:47:21 +0100 4914697 http://www.medworm.com/index.php?rid=4914698&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyr18030005153260%2F In conclusion, the incidence of IP is increased in patients with DLBCL receiving rituximab-containing chemotherapy. Specific subgroups with lymphopenia at diagnosis may justify close scrutiny to detect pulmonary complications. Content Type Journal ArticlePages 1-7DOI 10.1007/s00277-011-1268-2Authors Yu-Chung Huang, Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Taipei, 112 Taiwan, Republic of ChinaChia-Jen Liu, Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Taipei, 112 Taiwan, Republic of ChinaChun-Yu Liu, Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4914698 Mon, 06 Jun 2011 14:57:52 +0100 4914698 http://www.medworm.com/index.php?rid=4914700&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnr57gn07g145380m%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00277-011-1264-6Authors Bing Shi, Department of Hematology, The 309th hospital of Chinese People’s Liberation Army, 17 Heishanhu Rd, Beijing, 100091 ChinaLihui Liu, Department of Hematology, The 309th hospital of Chinese People’s Liberation Army, 17 Heishanhu Rd, Beijing, 100091 ChinaLiping Ye, Department of Hematology, The 309th hospital of Chinese People’s Liberation Army, 17 Heishanhu Rd, Beijing, 100091 China Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hematology) Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4914700 Mon, 06 Jun 2011 14:57:49 +0100 4914700 http://www.medworm.com/index.php?rid=4914699&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn222m3011qr14446%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00277-011-1272-6Authors Tomonori Nakazato, Department of Hematology, Yokohama Municipal Citizen’s Hospital, Yokohama, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555 JapanAi Mihara, Department of Hematology, Yokohama Municipal Citizen’s Hospital, Yokohama, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555 JapanChisako Ito, Department of Hematology, Yokohama Municipal Citizen’s Hospital, Yokohama, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555 JapanYukinari Sanada, Department of Hematology, Yokohama Municipal Citizen’s Hospital, Yokohama, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555 JapanYoshinobu Aisa, Department of Hematology, Yokohama Municipal Citizen’s Hospital, Yokohama, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555 J... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4914699 Mon, 06 Jun 2011 14:57:49 +0100 4914699 http://www.medworm.com/index.php?rid=4914701&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F72r31323t404h4mk%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00277-011-1271-7Authors Yumiko Yoshiki, Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113–8655, JapanGo Yamamoto, Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113–8655, JapanYutaka Takazawa, Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, JapanYasuhito Nannya, Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113–8655, JapanJunichi Ishida, Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, JapanRyozo Nagai, Department of Cardiovascular Medic... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4914701 Sat, 04 Jun 2011 06:06:24 +0100 4914701 http://www.medworm.com/index.php?rid=4914703&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn3353718k07n41uh%2F Abstract  von Willebrand disease (VWD) is the commonest inherited bleeding disorder, yet it has not been well recognized in Southeast Asia. The aim of this prospective study was to report our experience of VWD diagnosis and to establish the clinical presentations of VWD in Taiwan. From October 2003 to April 2010, 863 patients with suspicion of having an inherited bleeding disorder underwent VWD screening tests. Those with positive tests were selected for further clinical and laboratory evaluation. A nested gender- and age-matched control cohort underwent similar investigation for comparison. VWD was diagnosed by comprehensive laboratory tests including factor VIII clotting activity, von Willebrand factor antigen assay, VWF:ristocetin cofactor activity (VWF:RCo) and platelet... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4914703 Sat, 04 Jun 2011 06:06:23 +0100 4914703 http://www.medworm.com/index.php?rid=4914702&cid=s_33273_19_f&fid=33273&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxv0w1823w7p55571%2F Content Type Journal ArticlePages 1-3DOI 10.1007/s00277-011-1269-1Authors Bo Cai, Department of Hematology, General Hospital of People’s Liberation Army, 28 Fuxing Road, Beijing, 100853 ChinaWeidong Yang, Department of Hematology, Hospital of Anyang District, Anyang, Henan, ChinaYu Zhao, Department of Hematology, General Hospital of People’s Liberation Army, 28 Fuxing Road, Beijing, 100853 ChinaLei Yuan, Department of Hematology, General Hospital of People’s Liberation Army, 28 Fuxing Road, Beijing, 100853 ChinaLili Wang, Department of Hematology, General Hospital of People’s Liberation Army, 28 Fuxing Road, Beijing, 100853 ChinaLi Gao, Department of Hematology, General Hospital of People’s Liberation Army, 28 Fuxing Road, Beijing, 100853 ChinaNan Wang, Department of Hematolo... Annals of Hematology journals http://www.medworm.com/rss/comments.php?id=4914702 Sat, 04 Jun 2011 06:06:23 +0100 4914702