MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Archives of General Psychiatry' source. Sun, 21 Mar 2010 17:36:22 +0100 http://www.medworm.com/index.php?rid=3322171&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F311-a%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322171 Mon, 01 Mar 2010 20:50:46 +0100 3322171 http://www.medworm.com/index.php?rid=3322170&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F311%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322170 Mon, 01 Mar 2010 20:50:46 +0100 3322170 http://www.medworm.com/index.php?rid=3322169&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F304%3Frss%3D1 Conclusion  Greater purpose in life is associated with a reduced risk of AD and MCI in community-dwelling older persons. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322169 Mon, 01 Mar 2010 20:50:46 +0100 3322169 http://www.medworm.com/index.php?rid=3322168&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F296%3Frss%3D1 Conclusions  The findings indicate for the first time in humans that PTSD is associated with selective volume loss of the CA3/dentate gyrus subfields, consistent with animal studies, implying that chronic stress suppresses neurogenesis and dendritic branching in these structures. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322168 Mon, 01 Mar 2010 20:50:46 +0100 3322168 http://www.medworm.com/index.php?rid=3322167&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F286%3Frss%3D1 Conclusion  Combined phenelzine and CBGT treatment is superior to either treatment alone and to placebo on dimensional measures and on rates of response and remission. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322167 Mon, 01 Mar 2010 20:50:46 +0100 3322167 http://www.medworm.com/index.php?rid=3322166&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F277%3Frss%3D1 Conclusions  Comprehensive neuropsychological function and white matter hyperintensity severity predicted MADRS scores prospectively over a 12-week treatment course with selective serotonin reuptake inhibitors in late-life depression. Baseline neuropsychological function differentiated remitters from nonremitters and predicted time to remission in a proportional hazards model. Predictor variables correlated highly with vascular risk factor severity. These data support the vascular depression hypothesis and highlight the importance of linking subtypes based on neuropsychological function and white matter integrity. Trial Registration  clinicaltrials.gov Identifier: NCT00045773 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322166 Mon, 01 Mar 2010 20:50:45 +0100 3322166 http://www.medworm.com/index.php?rid=3322165&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F270%3Frss%3D1 Conclusions  Compared with individuals at low familial risk of the development of depression, high-risk individuals have reduced hippocampal volume, indicating that neuroanatomic anomalies associated with depression may precede the onset of a depressive episode and influence the development and course of this disorder. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322165 Mon, 01 Mar 2010 20:50:45 +0100 3322165 http://www.medworm.com/index.php?rid=3322164&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F258%3Frss%3D1 Conclusions  BDNF promoter/exon IV is frequently hypermethylated in the Wernicke area of the postmortem brain of suicide subjects irrespective of genome-wide methylation levels, indicating that a gene-specific increase in DNA methylation could cause or contribute to the downregulation of BDNF expression in suicide subjects. The reported data reveal a novel link between epigenetic alteration in the brain and suicidal behavior. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322164 Mon, 01 Mar 2010 20:50:45 +0100 3322164 http://www.medworm.com/index.php?rid=3322163&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F252%3Frss%3D1 Conclusions  Derived risks may be informative for counseling. Patterns of transmission may support evolving assumptions about genetic overlap for traditional categories. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322163 Mon, 01 Mar 2010 20:50:45 +0100 3322163 http://www.medworm.com/index.php?rid=3322162&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F241%3Frss%3D1 Conclusions  The prediction model identified an increased risk of psychosis with appropriate prognostic accuracy in our sample. A 2-step risk assessment is proposed, with UHR and cognitive disturbance criteria serving as first-step criteria for general risk and the prognostic index as a second-step tool for further risk classification of each patient. This strategy will allow clinicians to target preventive measures and will support efforts to unveil the biological and environmental mechanisms underlying progression to psychosis. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322162 Mon, 01 Mar 2010 20:50:45 +0100 3322162 http://www.medworm.com/index.php?rid=3322161&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F231%3Frss%3D1 Conclusions  These findings suggest that schizophrenia is associated with elevated dopamine function in associative regions of the striatum. Because the precommissural dorsal caudate processes information from the dorsolateral prefrontal cortex, this observation also suggests that elevated subcortical dopamine function might adversely affect performance of the dorsolateral prefrontal cortex in schizophrenia. On the other hand, the absence of a group difference in the limbic striatum brings into question the therapeutic relevance of the mesolimbic selectivity of second-generation antipsychotic drugs. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322161 Mon, 01 Mar 2010 20:50:45 +0100 3322161 http://www.medworm.com/index.php?rid=3322160&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F220%3Frss%3D1 Conclusions  This meta-analysis confirms a reciprocal link between depression and obesity. Obesity was found to increase the risk of depression, most pronounced among Americans and for clinically diagnosed depression. In addition, depression was found to be predictive of developing obesity. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322160 Mon, 01 Mar 2010 20:50:45 +0100 3322160 http://www.medworm.com/index.php?rid=3322159&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F218%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322159 Mon, 01 Mar 2010 20:50:45 +0100 3322159 http://www.medworm.com/index.php?rid=3322158&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F217%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322158 Mon, 01 Mar 2010 20:50:45 +0100 3322158 http://www.medworm.com/index.php?rid=3322157&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F3%2F216%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322157 Mon, 01 Mar 2010 20:50:45 +0100 3322157 http://www.medworm.com/index.php?rid=3322156&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F2010.6v1%3Frss%3D1 Conclusions  Early cannabis use is associated with psychosis-related outcomes in young adults. The use of sibling pairs reduces the likelihood that unmeasured confounding explains these findings. This study provides further support for the hypothesis that early cannabis use is a risk-modifying factor for psychosis-related outcomes in young adults.Published online March 1, 2010 (doi:10.1001/archgenpsychiatry.2010.6). (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3322156 Mon, 01 Mar 2010 20:43:05 +0100 3322156 http://www.medworm.com/index.php?rid=3231332&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F197%3Frss%3D1 Conclusions  These results suggest abnormalities in visual processing and frontostriatal systems in BDD. Hypoactivation in the occipital cortex for low spatial frequency faces may indicate either primary visual system abnormalities for configural face elements or top-down modulation of visual processing. Frontostriatal hyperactivity may be associated both with aversion and with symptoms of obsessive thoughts and compulsive behaviors. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231332 Mon, 01 Feb 2010 20:51:36 +0100 3231332 http://www.medworm.com/index.php?rid=3231331&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F187%3Frss%3D1 Conclusions  When compared with patients who received placebo or underwent Problem Solving Therapy, stroke patients who received escitalopram showed improvement in global cognitive functioning, specifically in verbal and visual memory functions. This beneficial effect of escitalopram was independent of its effect on depression. The utility of antidepressants in the process of poststroke recovery should be further investigated. Trial Registration  clinicaltrials.gov Identifier: NCT00071643 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231331 Mon, 01 Feb 2010 20:51:36 +0100 3231331 http://www.medworm.com/index.php?rid=3231330&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F178%3Frss%3D1 Conclusion  The results suggest that face-processing difficulties in toddlers with ASD involve disruption of an attentional mechanism that typically supports deeper processing of these highly socially relevant stimuli. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231330 Mon, 01 Feb 2010 20:51:36 +0100 3231330 http://www.medworm.com/index.php?rid=3231329&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F168%3Frss%3D1 Conclusion  This large-scale extended pedigree study of cognitive functioning in bipolar disorder identifies measures of processing speed, working memory, and declarative (facial) memory as candidate endophenotypes for bipolar disorder. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231329 Mon, 01 Feb 2010 20:51:36 +0100 3231329 http://www.medworm.com/index.php?rid=3231328&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F155%3Frss%3D1 Conclusions  Marked changes in functionally relevant molecules in schizophrenia point to a pivotal role for extracellular matrix–glial interactions in the pathogenesis of this disease. Disruption of these interactions, unsuspected thus far, may represent a unifying factor contributing to disturbances of neuronal migration, synaptic connectivity, and GABAergic, glutamatergic, and dopaminergic neurotransmission in schizophrenia. The lack of CSPG abnormalities in bipolar disorder points to a distinctive aspect of the pathophysiology of schizophrenia in key medial temporal lobe regions. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231328 Mon, 01 Feb 2010 20:51:36 +0100 3231328 http://www.medworm.com/index.php?rid=3231327&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F146%3Frss%3D1 Conclusions  Long-chain -3 PUFAs reduce the risk of progression to psychotic disorder and may offer a safe and efficacious strategy for indicated prevention in young people with subthreshold psychotic states. Trial Registration  clinicaltrials.gov Identifier: NCT00396643 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231327 Mon, 01 Feb 2010 20:51:36 +0100 3231327 http://www.medworm.com/index.php?rid=3231326&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F133%3Frss%3D1 Conclusion  These results indicate that in both healthy subjects and patients with schizophrenia hippocampal volume is plastic in response to aerobic exercise. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231326 Mon, 01 Feb 2010 20:51:36 +0100 3231326 http://www.medworm.com/index.php?rid=3231325&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F124%3Frss%3D1 Conclusions  The overall statistically significant associations of CAs with adult DSM-IV/Composite International Diagnostic Interview disorders are due largely to component associations with onsets rather than with persistence, indirectly suggesting that the greatest focus of public health attention on CAs should be aimed at primary rather than secondary prevention. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231325 Mon, 01 Feb 2010 20:51:36 +0100 3231325 http://www.medworm.com/index.php?rid=3231324&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F113%3Frss%3D1 Conclusions  The fact that associations increased with length of recall raises the possibility of recall bias inflating estimates. Even considering this, the results suggest that CAs have powerful and often subadditive associations with the onset of many types of largely primary mental disorders throughout the life course. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231324 Mon, 01 Feb 2010 20:51:36 +0100 3231324 http://www.medworm.com/index.php?rid=3231323&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F111%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231323 Mon, 01 Feb 2010 20:51:35 +0100 3231323 http://www.medworm.com/index.php?rid=3231322&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F110%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231322 Mon, 01 Feb 2010 20:51:35 +0100 3231322 http://www.medworm.com/index.php?rid=3231321&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F109%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231321 Mon, 01 Feb 2010 20:51:35 +0100 3231321 http://www.medworm.com/index.php?rid=3231320&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F2%2F108%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231320 Mon, 01 Feb 2010 20:51:35 +0100 3231320 http://www.medworm.com/index.php?rid=3231319&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F2009.201v1%3Frss%3D1 Conclusions  Our results suggest that a combination of several independent risk alleles within the NTRK2 locus is associated with SA in depressed patients, further supporting a role of neurotrophins in the pathophysiology of suicide.Published online February 1, 2010 (doi:10.1001/archgenpsychiatry.2009.201). (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3231319 Mon, 01 Feb 2010 20:43:11 +0100 3231319 http://www.medworm.com/index.php?rid=3142384&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F94%3Frss%3D1 Conclusions  Interpersonal psychotherapy and CBTgsh are significantly more effective than BWL in eliminating binge eating after 2 years. Guided self-help based on cognitive behavior therapy is a first-line treatment option for most patients with BED, with IPT (or full cognitive behavior therapy) used for patients with low self-esteem and high eating disorder psychopathology. Trial Registration  clinicaltrials.gov Identifier: NCT00060762 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142384 Mon, 04 Jan 2010 20:51:26 +0100 3142384 http://www.medworm.com/index.php?rid=3142383&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F85%3Frss%3D1 Conclusion  This study extends the evidence that brief, personality-targeted interventions can prevent the onset and escalation of substance misuse in high-risk adolescents. Trial Registration  clinicaltrials.gov Identifier: NCT00344474 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142383 Mon, 04 Jan 2010 20:51:26 +0100 3142383 http://www.medworm.com/index.php?rid=3142382&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F78%3Frss%3D1 Conclusions  To our knowledge, this is the first demonstration that temperamental differences measured at 4 months of age have implications for the architecture of human cerebral cortex lasting into adulthood. Understanding the developmental mechanisms that shape these differences may offer new ways to understand mood and anxiety disorders as well as the formation of adult personality. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142382 Mon, 04 Jan 2010 20:51:26 +0100 3142382 http://www.medworm.com/index.php?rid=3142381&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F77%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142381 Mon, 04 Jan 2010 20:51:26 +0100 3142381 http://www.medworm.com/index.php?rid=3142380&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F69%3Frss%3D1 Conclusions  Tailored approaches are needed to ensure that standard safety advice is effectively communicated to these vulnerable families. In particular, mentally ill pregnant women should be encouraged and better supported to stop smoking. Families with 2 affected parents require particularly strong support. A clearer understanding is needed as to why high risk factor prevalence persists among these parents. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142380 Mon, 04 Jan 2010 20:51:26 +0100 3142380 http://www.medworm.com/index.php?rid=3142379&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F59%3Frss%3D1 Conclusions  The brains of autistic individuals have abnormalities in both serotonin transporter and dopamine transporter binding. The present findings indicate that the gross abnormalities in these neurotransmitter systems may underpin the neurophysiologic mechanism of autism. Our sample was not characteristic or representative of a typical sample of adults with autism in the community. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142379 Mon, 04 Jan 2010 20:51:26 +0100 3142379 http://www.medworm.com/index.php?rid=3142378&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F47%3Frss%3D1 Conclusions  Anxiety and depressive disorders appear to differ with regard to risk constellations and temporal longitudinal patterns, and GAD is a heterogeneous disorder that is, overall, more closely related to other anxiety disorders than to depressive disorders. More work is needed to elucidate the potentially unique aspects of pathways and mechanisms involved in the etiopathogenesis of GAD. Grouping GAD with depressive disorders, as suggested by cross-sectional features and diagnostic comorbidity patterns, minimizes the importance of longitudinal data on risk factors and symptom trajectories. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142378 Mon, 04 Jan 2010 20:51:26 +0100 3142378 http://www.medworm.com/index.php?rid=3142377&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F37%3Frss%3D1 Conclusions  Few Americans with recent major depression have used depression therapies and guideline-concordant therapies; however, the lowest rates of use were found among Mexican American and African American individuals. Ethnic/racial differences were found despite comparable depression care need. More Americans with recent major depression used psychotherapy over pharmacotherapy, and these differences were most pronounced among Mexican American and African American individuals. This report underscores the importance of disaggregating ethnic/racial groups and depression therapies in understanding and directing efforts to improve depression care in the United States. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142377 Mon, 04 Jan 2010 20:51:26 +0100 3142377 http://www.medworm.com/index.php?rid=3142376&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F26%3Frss%3D1 Conclusions  There has been a recent significant increase in polypharmacy involving antidepressant and antipsychotic medications. While some of these combinations are supported by clinical trials, many are of unproven efficacy. These trends put patients at increased risk of drug-drug interactions with uncertain gains for quality of care and clinical outcomes. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142376 Mon, 04 Jan 2010 20:51:26 +0100 3142376 http://www.medworm.com/index.php?rid=3142375&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F17%3Frss%3D1 Conclusions  In a Medicaid-receiving population, baseline glucose and lipid testing for SGA-treated patients was infrequent and showed little change following the diabetes warning and monitoring recommendations. A change in SGA drug selection consistent with intentions to reduce metabolic risk was observed. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142375 Mon, 04 Jan 2010 20:51:26 +0100 3142375 http://www.medworm.com/index.php?rid=3142374&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F9%3Frss%3D1 Conclusion  The results suggest that frontal cortical serotonin2A receptors are involved in the pathophysiology of schizophrenia. Trial Registration  clinicaltrials.gov Identifier: NCT00207064 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142374 Mon, 04 Jan 2010 20:51:26 +0100 3142374 http://www.medworm.com/index.php?rid=3142373&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F7%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142373 Mon, 04 Jan 2010 20:51:26 +0100 3142373 http://www.medworm.com/index.php?rid=3142372&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F5%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142372 Mon, 04 Jan 2010 20:51:26 +0100 3142372 http://www.medworm.com/index.php?rid=3142371&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F67%2F1%2F4%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3142371 Mon, 04 Jan 2010 20:51:26 +0100 3142371 http://www.medworm.com/index.php?rid=3066877&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1382%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066877 Mon, 07 Dec 2009 20:51:35 +0100 3066877 http://www.medworm.com/index.php?rid=3066876&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1373%3Frss%3D1 Conclusions  Cerebral cortical volume, thickness, and area may be smaller in adult chronic severe PTSD; however, the extracted structural variables did not mediate relations between intelligence and PTSD. The 4 regions exhibiting especially smaller cortical volumes in this sample share involvement in mechanisms subserving "top-down" facilitation of the identification of objects and words. Compromise of these regions may result in difficulty in relearning pretrauma schemata for interpreting the civilian physical and social environments. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066876 Mon, 07 Dec 2009 20:51:35 +0100 3066876 http://www.medworm.com/index.php?rid=3066875&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1361%3Frss%3D1 Conclusions  Our findings provide new insights into the functional neuroanatomy of the human amygdala and converge with connectivity studies in experimental animals. In GAD, we find evidence of an intra-amygdalar abnormality and engagement of a compensatory frontoparietal executive control network, consistent with cognitive theories of GAD. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066875 Mon, 07 Dec 2009 20:51:35 +0100 3066875 http://www.medworm.com/index.php?rid=3066874&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1354%3Frss%3D1 Conclusions  Despite Food and Drug Administration reports regarding increased risk of suicidality associated with AED treatment, the current study reveals that, as a class, AEDs do not increase risk of suicide attempts in patients with bipolar disorder relative to patients not treated with an AED or lithium. Use of AEDs reduces suicide attempt rates both relative to patients not receiving any psychotropic medication and relative to their pretreatment levels. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066874 Mon, 07 Dec 2009 20:51:35 +0100 3066874 http://www.medworm.com/index.php?rid=3066873&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1341%3Frss%3D1 Conclusions  Data suggest that MDD is a heterogeneous concept including a large group with subthreshold BPD, which is clinically significant and shares similarities with BPD. Findings might support the need for a broader concept and a more comprehensive screening of bipolarity, which could be substantial for future research and adequate treatment of patients with bipolarity. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066873 Mon, 07 Dec 2009 20:51:35 +0100 3066873 http://www.medworm.com/index.php?rid=3066872&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1332%3Frss%3D1 Conclusion  Cognitive behavioral therapy is an effective treatment for older people with depressive disorder and appears to be associated with its specific effects. Trial Registration  isrctn.org Identifier: ISRCTN18271323 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066872 Mon, 07 Dec 2009 20:51:35 +0100 3066872 http://www.medworm.com/index.php?rid=3066871&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1322%3Frss%3D1 Conclusions  Paroxetine appears to have a specific pharmacological effect on personality that is distinct from its effect on depression. If replicated, this pattern would disconfirm the state effect hypothesis and instead support the notion that SSRIs' effects on personality go beyond and perhaps contribute to their antidepressant effects. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066871 Mon, 07 Dec 2009 20:51:35 +0100 3066871 http://www.medworm.com/index.php?rid=3066870&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1313%3Frss%3D1 Conclusions  In these young adults with low levels of lead exposure, higher blood lead levels were associated with increased odds of major depression and panic disorders. Exposure to lead at levels generally considered safe could result in adverse mental health outcomes. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066870 Mon, 07 Dec 2009 20:51:35 +0100 3066870 http://www.medworm.com/index.php?rid=3066869&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1304%3Frss%3D1 Conclusions  Elevated MAO-A binding after SSRI treatment indicates persistence of a monoamine-lowering process not present in health. This provides a strong conceptual rationale for continuing SSRI treatment during early remission. Greater MAO-A binding in the prefrontal and anterior cingulate cortex in subjects with MDD in recovery and its association with subsequent recurrence argue that deficient monoamine neuromodulation may persist into recovery and contribute to recurrence. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066869 Mon, 07 Dec 2009 20:51:35 +0100 3066869 http://www.medworm.com/index.php?rid=3066868&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1295%3Frss%3D1 Conclusions  The study results support a key role in LO for visual masking, consistent with previous studies in healthy controls. The current results indicate that patients fail to activate LO to the same extent as controls during visual processing regardless of stimulus visibility, suggesting a neural basis for the visual masking deficit, and possibly other visual integration deficits, in schizophrenia. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066868 Mon, 07 Dec 2009 20:51:35 +0100 3066868 http://www.medworm.com/index.php?rid=3066867&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1287%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066867 Mon, 07 Dec 2009 20:51:35 +0100 3066867 http://www.medworm.com/index.php?rid=3066866&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1286%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066866 Mon, 07 Dec 2009 20:51:35 +0100 3066866 http://www.medworm.com/index.php?rid=3066865&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1285%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066865 Mon, 07 Dec 2009 20:51:35 +0100 3066865 http://www.medworm.com/index.php?rid=3066864&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1282%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066864 Mon, 07 Dec 2009 20:51:35 +0100 3066864 http://www.medworm.com/index.php?rid=3066863&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F12%2F1281%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=3066863 Mon, 07 Dec 2009 20:51:35 +0100 3066863 http://www.medworm.com/index.php?rid=2958731&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1263%3Frss%3D1 Conclusions  Hypertension and the expression of an innate pro-inflammatory cytokine profile in middle age are early risk factors of AD in old age. For the offspring of affected families, it provides clues for screening and preventive strategies, of which blood pressure control can be implemented directly. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958731 Mon, 02 Nov 2009 21:05:22 +0100 2958731 http://www.medworm.com/index.php?rid=2958730&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1253%3Frss%3D1 Conclusion  While the nicotine lozenge, bupropion, and bupropion plus lozenge produced effects that were comparable with those reported in previous research, the nicotine patch plus lozenge produced the greatest benefit relative to placebo for smoking cessation. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958730 Mon, 02 Nov 2009 21:05:22 +0100 2958730 http://www.medworm.com/index.php?rid=2958729&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1244%3Frss%3D1 Conclusions  We speculate that PEMCS interferes with the development of the OFC and, in turn, increases the likelihood of drug use among adolescents. In contrast, we suggest that, among nonexposed adolescents, drug experimentation influences the OFC thickness via processes akin to experience-induced plasticity. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958729 Mon, 02 Nov 2009 21:05:22 +0100 2958729 http://www.medworm.com/index.php?rid=2958728&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1233%3Frss%3D1 Conclusions  These results suggest that sequence variations in SLC1A1 are associated with susceptibility to AAP-induced OC symptoms. This is the first published pharmacogenetic study on this phenomenon and provides preliminary evidence of the involvement of glutamatergic neurotransmission in the pathogenesis of AAP-induced OC symptoms. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958728 Mon, 02 Nov 2009 21:05:22 +0100 2958728 http://www.medworm.com/index.php?rid=2958727&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1221%3Frss%3D1 Conclusions  Structural deficits in prefrontotemporal brain regions are linked to THI exposures. These brain lesions are associated with the symptom severity of depression in Vietnamese ex–political detainees. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958727 Mon, 02 Nov 2009 21:05:22 +0100 2958727 http://www.medworm.com/index.php?rid=2958726&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1214%3Frss%3D1 Conclusions  Among patients with heart disease, PTSD is more strongly associated with patient-reported cardiovascular health status than objective measures of cardiac function. Future studies should explore whether assessing and treating PTSD symptoms can improve function and quality of life in patients with heart disease. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958726 Mon, 02 Nov 2009 21:05:22 +0100 2958726 http://www.medworm.com/index.php?rid=2958725&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1201%3Frss%3D1 Conclusions  Participants who had both childhood adversity and adult traumatic events were more likely to develop lifetime PTSD compared with those who experienced either type of adverse event. The risk was increased in individuals with 1 or 2 copies of the S’ (S) allele compared with the L’ (L) homozygotes. Our study provides additional direct evidence that PTSD is influenced by the interactive effect of environmental and genetic factors. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958725 Mon, 02 Nov 2009 21:05:22 +0100 2958725 http://www.medworm.com/index.php?rid=2958724&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1189%3Frss%3D1 Conclusions  This study directly supports the hypothesis that OCD is associated with functional alterations of brain corticostriatal networks. Specifically, our findings emphasize abnormal and heightened functional connectivity of ventrolimbic corticostriatal regions in patients with OCD. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958724 Mon, 02 Nov 2009 21:05:22 +0100 2958724 http://www.medworm.com/index.php?rid=2958723&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1178%3Frss%3D1 Conclusions  Although 37.5% of the participants experienced partial response or remitted in phase 2, neither form of adjunctive psychotherapy significantly improved outcomes over that of a flexible, individualized pharmacotherapy regimen alone. A longitudinal assessment of later-emerging benefits is ongoing. Trial Registration  clinicaltrials.gov Identifier: NCT00057551 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958723 Mon, 02 Nov 2009 21:05:22 +0100 2958723 http://www.medworm.com/index.php?rid=2958722&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1173%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958722 Mon, 02 Nov 2009 21:05:22 +0100 2958722 http://www.medworm.com/index.php?rid=2958721&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1162%3Frss%3D1 Conclusions  Insular, cingulate, and striatal function during an executive task is normally modulated by variation in the dopamine transporter gene. Its effect on activation in the dorsolateral prefrontal cortex and ventral striatum is altered in patients with schizophrenia. This may reflect altered dopamine function in these regions in schizophrenia. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958721 Mon, 02 Nov 2009 21:05:22 +0100 2958721 http://www.medworm.com/index.php?rid=2958720&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1159%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958720 Mon, 02 Nov 2009 21:05:22 +0100 2958720 http://www.medworm.com/index.php?rid=2958719&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1158%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958719 Mon, 02 Nov 2009 21:05:22 +0100 2958719 http://www.medworm.com/index.php?rid=2958718&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1154%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2958718 Mon, 02 Nov 2009 21:05:22 +0100 2958718 http://www.medworm.com/index.php?rid=2954354&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1263%3Frss%3D1 Conclusions  Hypertension and the expression of an innate pro-inflammatory cytokine profile in middle age are early risk factors of AD in old age. For the offspring of affected families, it provides clues for screening and preventive strategies, of which blood pressure control can be implemented directly. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954354 Mon, 02 Nov 2009 21:05:22 +0100 2954354 http://www.medworm.com/index.php?rid=2954353&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1253%3Frss%3D1 Conclusion  While the nicotine lozenge, bupropion, and bupropion plus lozenge produced effects that were comparable with those reported in previous research, the nicotine patch plus lozenge produced the greatest benefit relative to placebo for smoking cessation. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954353 Mon, 02 Nov 2009 21:05:22 +0100 2954353 http://www.medworm.com/index.php?rid=2954352&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1244%3Frss%3D1 Conclusions  We speculate that PEMCS interferes with the development of the OFC and, in turn, increases the likelihood of drug use among adolescents. In contrast, we suggest that, among nonexposed adolescents, drug experimentation influences the OFC thickness via processes akin to experience-induced plasticity. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954352 Mon, 02 Nov 2009 21:05:22 +0100 2954352 http://www.medworm.com/index.php?rid=2954351&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1233%3Frss%3D1 Conclusions  These results suggest that sequence variations in SLC1A1 are associated with susceptibility to AAP-induced OC symptoms. This is the first published pharmacogenetic study on this phenomenon and provides preliminary evidence of the involvement of glutamatergic neurotransmission in the pathogenesis of AAP-induced OC symptoms. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954351 Mon, 02 Nov 2009 21:05:22 +0100 2954351 http://www.medworm.com/index.php?rid=2954350&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1221%3Frss%3D1 Conclusions  Structural deficits in prefrontotemporal brain regions are linked to THI exposures. These brain lesions are associated with the symptom severity of depression in Vietnamese ex–political detainees. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954350 Mon, 02 Nov 2009 21:05:22 +0100 2954350 http://www.medworm.com/index.php?rid=2954349&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1214%3Frss%3D1 Conclusions  Among patients with heart disease, PTSD is more strongly associated with patient-reported cardiovascular health status than objective measures of cardiac function. Future studies should explore whether assessing and treating PTSD symptoms can improve function and quality of life in patients with heart disease. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954349 Mon, 02 Nov 2009 21:05:22 +0100 2954349 http://www.medworm.com/index.php?rid=2954348&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1201%3Frss%3D1 Conclusions  Participants who had both childhood adversity and adult traumatic events were more likely to develop lifetime PTSD compared with those who experienced either type of adverse event. The risk was increased in individuals with 1 or 2 copies of the S’ (S) allele compared with the L’ (L) homozygotes. Our study provides additional direct evidence that PTSD is influenced by the interactive effect of environmental and genetic factors. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954348 Mon, 02 Nov 2009 21:05:22 +0100 2954348 http://www.medworm.com/index.php?rid=2954347&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1189%3Frss%3D1 Conclusions  This study directly supports the hypothesis that OCD is associated with functional alterations of brain corticostriatal networks. Specifically, our findings emphasize abnormal and heightened functional connectivity of ventrolimbic corticostriatal regions in patients with OCD. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954347 Mon, 02 Nov 2009 21:05:22 +0100 2954347 http://www.medworm.com/index.php?rid=2954346&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1178%3Frss%3D1 Conclusions  Although 37.5% of the participants experienced partial response or remitted in phase 2, neither form of adjunctive psychotherapy significantly improved outcomes over that of a flexible, individualized pharmacotherapy regimen alone. A longitudinal assessment of later-emerging benefits is ongoing. Trial Registration  clinicaltrials.gov Identifier: NCT00057551 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954346 Mon, 02 Nov 2009 21:05:22 +0100 2954346 http://www.medworm.com/index.php?rid=2954345&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1173%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954345 Mon, 02 Nov 2009 21:05:22 +0100 2954345 http://www.medworm.com/index.php?rid=2954344&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1162%3Frss%3D1 Conclusions  Insular, cingulate, and striatal function during an executive task is normally modulated by variation in the dopamine transporter gene. Its effect on activation in the dorsolateral prefrontal cortex and ventral striatum is altered in patients with schizophrenia. This may reflect altered dopamine function in these regions in schizophrenia. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954344 Mon, 02 Nov 2009 21:05:22 +0100 2954344 http://www.medworm.com/index.php?rid=2954343&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1159%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954343 Mon, 02 Nov 2009 21:05:22 +0100 2954343 http://www.medworm.com/index.php?rid=2954342&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1158%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954342 Mon, 02 Nov 2009 21:05:22 +0100 2954342 http://www.medworm.com/index.php?rid=2954341&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F11%2F1154%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2954341 Mon, 02 Nov 2009 21:05:22 +0100 2954341 http://www.medworm.com/index.php?rid=2865509&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1135%3Frss%3D1 Conclusion  Heterogeneity in selective attention in ADHD can be explained by a replicated genetic risk factor for ADHD, the 10/3 DAT1 haplotype. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865509 Mon, 05 Oct 2009 19:51:11 +0100 2865509 http://www.medworm.com/index.php?rid=2865508&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1124%3Frss%3D1 Conclusions  Individual differences in the function of the endogenous µ-receptor system predict personality traits that confer vulnerability to or resiliency against risky behaviors such as the predisposition to develop substance use disorders. These personality traits are also implicated in psychopathological states (eg, personality disorders) in which variations in the function of this neurotransmitter system also may play a role. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865508 Mon, 05 Oct 2009 19:51:11 +0100 2865508 http://www.medworm.com/index.php?rid=2865507&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1116%3Frss%3D1 Conclusions  Attaining high (≥43 µg/mL) IgG anticocaine antibody levels was associated with significantly reduced cocaine use, but only 38% of the vaccinated subjects attained these IgG levels and they had only 2 months of adequate cocaine blockade. Thus, we need improved vaccines and boosters. Trial Registration  clinicaltrials.gov Identifier: NCT00142857 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865507 Mon, 05 Oct 2009 19:51:11 +0100 2865507 http://www.medworm.com/index.php?rid=2865506&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1108%3Frss%3D1 Conclusions  The naltrexone implant effectively reduced relapse to regular heroin use compared with oral naltrexone and was not associated with major adverse events. Clinical Trial Registration  anzctr.org.au Identifier: ACTRN12606000308594 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865506 Mon, 05 Oct 2009 19:51:11 +0100 2865506 http://www.medworm.com/index.php?rid=2865505&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1099%3Frss%3D1 Conclusions  Enhanced resting metabolic activity in the dACC/MCC appears to represent a familial risk factor for developing PTSD after exposure to psychological trauma. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865505 Mon, 05 Oct 2009 19:51:11 +0100 2865505 http://www.medworm.com/index.php?rid=2865504&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1090%3Frss%3D1 Conclusions  Our results suggest a potential protective role of the MDP with regard to the prevention of depressive disorders; additional longitudinal studies and trials are needed to confirm these findings. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865504 Mon, 05 Oct 2009 19:51:11 +0100 2865504 http://www.medworm.com/index.php?rid=2865503&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1081%3Frss%3D1 Conclusion  Compared with current primary care practice, a structured telephone program including care management and cognitive behavioral psychotherapy has significant clinical benefit with only a modest increase in health services cost. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865503 Mon, 05 Oct 2009 19:51:11 +0100 2865503 http://www.medworm.com/index.php?rid=2865502&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1072%3Frss%3D1 Conclusions  These findings validate the human open field paradigm and identify defining characteristics of bipolar mania that are distinct from those of schizophrenia. This cross-species study of exploration calls into question an accepted animal model of mania and should help to develop more accurate human and animal models, which are essential to the identification of the neurobiological underpinnings of neuropsychiatric disorders. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865502 Mon, 05 Oct 2009 19:51:11 +0100 2865502 http://www.medworm.com/index.php?rid=2865501&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1058%3Frss%3D1 Conclusion  Genetic analyses of heritable, homogeneous phenotypes may improve the power of linkage and association studies of schizophrenia and thus have relevance to the design and analysis of genome-wide association studies. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865501 Mon, 05 Oct 2009 19:51:11 +0100 2865501 http://www.medworm.com/index.php?rid=2865500&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1045%3Frss%3D1 Conclusions  NOS1 is associated with clinically significant variation in cognition. Whether this is a mechanism by which schizophrenia risk is increased (eg, via an influence on cognitive reserve) is yet to be confirmed. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865500 Mon, 05 Oct 2009 19:51:11 +0100 2865500 http://www.medworm.com/index.php?rid=2865499&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1044%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865499 Mon, 05 Oct 2009 19:51:11 +0100 2865499 http://www.medworm.com/index.php?rid=2865498&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1043%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865498 Mon, 05 Oct 2009 19:51:10 +0100 2865498 http://www.medworm.com/index.php?rid=2865497&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F10%2F1042%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2865497 Mon, 05 Oct 2009 19:51:10 +0100 2865497 http://www.medworm.com/index.php?rid=2774529&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F1022%3Frss%3D1 Conclusions  Severity of MDD measured within a few weeks of hospitalization for ACS or failure of MDD to improve during the 6 months following ACS predicted more than a doubling of mortality over 6.7 years of follow-up. Because persistent depression increases mortality and decreases medication adherence, physicians need to aggressively treat depression and be diligent in promoting adherence to guideline cardiovascular drug therapy. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774529 Sun, 06 Sep 2009 23:00:00 +0100 2774529 http://www.medworm.com/index.php?rid=2774528&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F1013%3Frss%3D1 Conclusion  Brief, adjunctive psychoeducational group psychotherapy is associated with improved outcome for children aged 8 to 12 years with major mood disorders. Trial Registration  clinicaltrials.gov Identifier: NCT00050557 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774528 Sun, 06 Sep 2009 23:00:00 +0100 2774528 http://www.medworm.com/index.php?rid=2774527&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F1005%3Frss%3D1 Conclusions  Boys and girls who display frequent bullying behavior should be evaluated for possible psychiatric problems, as bullying behaviors in concert with psychiatric symptoms are early markers of risk of psychiatric outcome. Among females, frequent childhood victimization predicts later psychiatric problems irrespective of psychiatric problems at baseline. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774527 Sun, 06 Sep 2009 23:00:00 +0100 2774527 http://www.medworm.com/index.php?rid=2774526&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F996%3Frss%3D1 Conclusions  In this study of army soldiers deployed to the Iraq war, only PTSD symptoms (among soldiers back from deployment for 1 year) were associated with a neuropsychological deficit (reduced attention). Greater combat intensity was associated with enhanced reaction time, irrespective of time since return. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774526 Sun, 06 Sep 2009 23:00:00 +0100 2774526 http://www.medworm.com/index.php?rid=2774525&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F986%3Frss%3D1 Conclusions  Results provide the first evidence, to our knowledge, of focal amygdala abnormalities in psychopathic individuals and corroborate findings from previous lesion studies. Findings support prior hypotheses of amygdala deficits in individuals with psychopathy and indicate that amygdala abnormalities contribute to emotional and behavioral symptoms of psychopathy. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774525 Sun, 06 Sep 2009 23:00:00 +0100 2774525 http://www.medworm.com/index.php?rid=2774524&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F978%3Frss%3D1 Conclusions  A haplotype in CRHR1 has been suggested to exert a protective effect against adult depression among research participants who reported maltreatment on the CTQ, a measure that elicits emotional memories. This suggests the hypothesis that CRHR1's protective effect may relate to its function in the consolidation of memories of emotionally arousing experiences. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774524 Sun, 06 Sep 2009 23:00:00 +0100 2774524 http://www.medworm.com/index.php?rid=2774523&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F966%3Frss%3D1 Conclusion  These results demonstrate the importance of multiple genetic factors combined with clinical features in the prediction of antidepressant drug treatment outcome, which underscores the multifactorial nature of this trait. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774523 Sun, 06 Sep 2009 23:00:00 +0100 2774523 http://www.medworm.com/index.php?rid=2774522&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F957%3Frss%3D1 Conclusion  The association of the monocyte pro-inflammatory state with BD is primarily the result of a common shared environmental factor. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774522 Sun, 06 Sep 2009 23:00:00 +0100 2774522 http://www.medworm.com/index.php?rid=2774521&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F947%3Frss%3D1 Conclusions  Weakly to moderately recurrent CNVs (transmitted or occurring de novo) seem to be causative or contributory factors for these diseases. Most of these CNVs (which contain genes involved in neurotransmission or in synapse formation and maintenance) are present in the 3 pathologic conditions (schizophrenia, autism, and mental retardation), supporting the existence of shared biologic pathways in these neurodevelopmental disorders. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774521 Sun, 06 Sep 2009 23:00:00 +0100 2774521 http://www.medworm.com/index.php?rid=2774520&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F938%3Frss%3D1 Conclusions  Taken as a whole, the results suggest that the CA1 subfield of the hippocampal subregion is differentially targeted by schizophrenia and related psychotic disorders. Interpreted in the context of previous studies, these findings inform underlying mechanisms of illness progression. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774520 Sun, 06 Sep 2009 23:00:00 +0100 2774520 http://www.medworm.com/index.php?rid=2774519&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F931%3Frss%3D1 Conclusions  The adoption of the described guidelines would help to protect the safety and rights of research subjects who participate in clinical trials of deep brain stimulation for disorders of mood, behavior, and thought and have further potential to benefit other stakeholders in the research process, including clinical researchers and device manufactures. That said, the adoption of the guidelines will require broad and substantial commitment from many of these same stakeholders. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774519 Sun, 06 Sep 2009 23:00:00 +0100 2774519 http://www.medworm.com/index.php?rid=2774518&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F930%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774518 Sun, 06 Sep 2009 23:00:00 +0100 2774518 http://www.medworm.com/index.php?rid=2774517&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F929%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774517 Sun, 06 Sep 2009 23:00:00 +0100 2774517 http://www.medworm.com/index.php?rid=2774516&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F9%2F928%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2774516 Sun, 06 Sep 2009 23:00:00 +0100 2774516 http://www.medworm.com/index.php?rid=2667285&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F917%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667285 Sun, 02 Aug 2009 23:00:00 +0100 2667285 http://www.medworm.com/index.php?rid=2667284&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F916-a%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667284 Sun, 02 Aug 2009 23:00:00 +0100 2667284 http://www.medworm.com/index.php?rid=2667283&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F916%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667283 Sun, 02 Aug 2009 23:00:00 +0100 2667283 http://www.medworm.com/index.php?rid=2667282&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F915-a%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667282 Sun, 02 Aug 2009 23:00:00 +0100 2667282 http://www.medworm.com/index.php?rid=2667281&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F915%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667281 Sun, 02 Aug 2009 23:00:00 +0100 2667281 http://www.medworm.com/index.php?rid=2667280&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F906%3Frss%3D1 Conclusions  Evidence-based mental health response is feasible, but requires targeted resources, increased provider capacity, and advanced planning. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667280 Sun, 02 Aug 2009 23:00:00 +0100 2667280 http://www.medworm.com/index.php?rid=2667279&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F897%3Frss%3D1 Conclusions  Preschool depression, similar to childhood depression, is not a developmentally transient syndrome but rather shows chronicity and/or recurrence. Homotypic continuity of preschool MDD during a 24-month period was found. These results underscore the clinical and public health importance of identification of depression as early as preschool. Further follow-up of preschoolers with depression is warranted to inform the longitudinal course throughout childhood. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667279 Sun, 02 Aug 2009 23:00:00 +0100 2667279 http://www.medworm.com/index.php?rid=2667278&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F888%3Frss%3D1 Conclusions  These findings explain the way that, in typical development, the increased dimensions of the right frontal and left occipital cortical regions emerge in adulthood from the reversed pattern of childhood cortical asymmetries. Loss of the prefrontal component of this evolving asymmetry in ADHD is compatible with disruption of prefrontal function in the disorder and demonstrates the way that disruption of typical processes of asymmetry can inform our understanding of neurodevelopmental disorders. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667278 Sun, 02 Aug 2009 23:00:00 +0100 2667278 http://www.medworm.com/index.php?rid=2667277&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F878%3Frss%3D1 Conclusions  The high prefrontal glutamate levels documented in this study may play an important role in the genesis of the low cognitive performance and mild depression frequently observed in patients with type 1 diabetes. Therapeutic options that alter glutamatergic neurotransmission may be of benefit in treating central nervous system–related changes in patients with adult type 1 diabetes. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667277 Sun, 02 Aug 2009 23:00:00 +0100 2667277 http://www.medworm.com/index.php?rid=2667276&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F866%3Frss%3D1 Conclusions  There is a broad reduction of 4β2*-nAChR availability in patients with PD without clinically manifest dementia or depression compared with healthy volunteers. Reduced 4β2*-nAChR binding in patients with PD within the subcortical and cortical regions is associated with the severity of mild cognitive or depressive symptoms. These results provide novel in vivo evidence for a role of the cholinergic neurotransmission in psychiatric comorbidity of PD. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667276 Sun, 02 Aug 2009 23:00:00 +0100 2667276 http://www.medworm.com/index.php?rid=2667275&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F857%3Frss%3D1 Conclusions  Although the MD-CAD relationship across the lifespan is modest, time-dependent models reveal stronger associations. The sustained effect of CAD onset on MD risk is much stronger than vice versa. The effect of MD on CAD is largely acute, and the longer-term effects are apparently mediated via depressive recurrence. When examined separately, in men, environmental effects, which are often acute, play a large role in MD-CAD comorbidity, whereas in women, chronic effects, which are in part genetic, are more important. In men, genetic sources of MD-CAD comorbidity are more important in younger members of the sample. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667275 Sun, 02 Aug 2009 23:00:00 +0100 2667275 http://www.medworm.com/index.php?rid=2667274&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F848%3Frss%3D1 Conclusions  From 1996 to 2005, there was a marked and broad expansion in antidepressant treatment in the United States, with persisting low rates of treatment among racial/ethnic minorities. During this period, individuals treated with antidepressants became more likely to also receive treatment with antipsychotic medications and less likely to undergo psychotherapy. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667274 Sun, 02 Aug 2009 23:00:00 +0100 2667274 http://www.medworm.com/index.php?rid=2667273&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F838%3Frss%3D1 Conclusions  Combination pharmacotherapy is efficacious for the treatment of MD with psychotic features. Future research must determine the benefits vs risks of continuing atypical antipsychotic medications beyond 12 weeks. Trial Registration  clinicaltrials.gov Identifier: NCT00056472 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667273 Sun, 02 Aug 2009 23:00:00 +0100 2667273 http://www.medworm.com/index.php?rid=2667272&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F828%3Frss%3D1 Conclusion  The NRG1 gene contributes to the susceptibility for schizophrenia in the northern Swedish population. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667272 Sun, 02 Aug 2009 23:00:00 +0100 2667272 http://www.medworm.com/index.php?rid=2667271&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F811%3Frss%3D1 Conclusions  Healthy adults and schizophrenic patients activate a qualitatively similar neural network during executive task performance, consistent with the engagement of a general-purpose cognitive control network, with critical nodes in the dorsolateral PFC and ACC. Nevertheless, patients with schizophrenia show altered activity with deficits in the dorsolateral PFC, ACC, and mediodorsal nucleus of the thalamus. Increases in activity are evident in other PFC areas, which could be compensatory in nature. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667271 Sun, 02 Aug 2009 23:00:00 +0100 2667271 http://www.medworm.com/index.php?rid=2667270&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F809%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667270 Sun, 02 Aug 2009 23:00:00 +0100 2667270 http://www.medworm.com/index.php?rid=2667269&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F808%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667269 Sun, 02 Aug 2009 23:00:00 +0100 2667269 http://www.medworm.com/index.php?rid=2667268&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F8%2F804%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2667268 Sun, 02 Aug 2009 23:00:00 +0100 2667268 http://www.medworm.com/index.php?rid=2576409&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F796-a%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576409 Sun, 05 Jul 2009 23:00:00 +0100 2576409 http://www.medworm.com/index.php?rid=2576408&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F796%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576408 Sun, 05 Jul 2009 23:00:00 +0100 2576408 http://www.medworm.com/index.php?rid=2576407&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F785%3Frss%3D1 Conclusions  While gender differences in most lifetime mental disorders were fairly stable over the time-space units studied, substantial intercohort narrowing of differences in major depression was found to be related to changes in the traditionality of female gender roles. Additional research is needed to understand why this temporal narrowing was confined to major depression. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576407 Sun, 05 Jul 2009 23:00:00 +0100 2576407 http://www.medworm.com/index.php?rid=2576406&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F773%3Frss%3D1 Conclusions  This is the first GWAS and follow-up study to identify a genome-wide significant association in alcohol dependence. Further independent studies are required to confirm these findings. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576406 Sun, 05 Jul 2009 23:00:00 +0100 2576406 http://www.medworm.com/index.php?rid=2576405&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F764%3Frss%3D1 Conclusions  Stringent tests of homotypic and heterotypic prediction patterns suggest a more developmentally and diagnostically nuanced picture in comparison with the previous literature. The putative link between adolescent and young adult depression was not supported. Oppositional defiant disorder was singular in being part of the developmental history of a wide range of young adult disorders. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576405 Sun, 05 Jul 2009 23:00:00 +0100 2576405 http://www.medworm.com/index.php?rid=2576404&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F756%3Frss%3D1 Conclusions  This study, the first to our knowledge that examines the efficacy of a glutamatergic agent in the treatment of trichotillomania, found that N-acetylcysteine demonstrated statistically significant reductions in trichotillomania symptoms. No adverse events occurred in the N-acetylcysteine group, and N-acetylcysteine was well tolerated. Pharmacologic modulation of the glutamate system may prove to be useful in the control of a range of compulsive behaviors. Trial Registration  clinicaltrials.gov Identifier: NCT00354770. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576404 Sun, 05 Jul 2009 23:00:00 +0100 2576404 http://www.medworm.com/index.php?rid=2576403&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F748%3Frss%3D1 Conclusions  This meta-analysis provides direct evidence for familial coaggregation of schizophrenia and BD, a finding that argues against the view that these disorders are entirely discrete diagnostic entities. Rather, a continuum model is supported. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576403 Sun, 05 Jul 2009 23:00:00 +0100 2576403 http://www.medworm.com/index.php?rid=2576402&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F738%3Frss%3D1 Conclusions  Associations between family history of a disorder and clinical features of that disorder in probands showed consistent direction of effects across depression, anxiety disorder, alcohol dependence, and drug dependence. For these disorder types, family history is useful for determining patients' clinical prognosis and for selecting cases for genetic studies. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576402 Sun, 05 Jul 2009 23:00:00 +0100 2576402 http://www.medworm.com/index.php?rid=2576401&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F729%3Frss%3D1 Conclusions  The efficacy of ECT is substantially increased by the addition of an antidepressant medication, but such medications may differ in whether they reduce or increase cognitive adverse effects. High-dose, right-sided, unilateral ECT is at least equivalent to moderate-dosage bilateral ECT in efficacy, but retains advantages with respect to cognitive adverse effects. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576401 Sun, 05 Jul 2009 23:00:00 +0100 2576401 http://www.medworm.com/index.php?rid=2576400&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F721%3Frss%3D1 Conclusions  The GSK3β gene may have a role in determining regional GM volume differences of the right hippocampus and bilateral superior temporal gyri. The association between genotype and brain structure was specific to the patients with MDD, suggesting that GSK3β genotypes might interact with MDD status. We speculate that this is a consequence of regional neocortical, glial, or neuronal growth or survival. In considering core cognitive features of MDD, the association of GSK3β polymorphisms with structural variation in the temporal lobe and hippocampus is of particular interest in the context of other evidence for structural and functional abnormalities in the hippocampi of patients with MDD. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576400 Sun, 05 Jul 2009 23:00:00 +0100 2576400 http://www.medworm.com/index.php?rid=2576399&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F713%3Frss%3D1 Conclusions  Individuals with severe mental disorder had only negligible excess rates of contact for heart disease. Given their excess mortality from heart disease and lower rates of invasive procedures after first contact, it would seem that the treatment for heart disease offered to these individuals in Denmark is neither sufficiently efficient nor sufficiently intensive. This undertreatment may explain part of their excess mortality. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576399 Sun, 05 Jul 2009 23:00:00 +0100 2576399 http://www.medworm.com/index.php?rid=2576398&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F712%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576398 Sun, 05 Jul 2009 23:00:00 +0100 2576398 http://www.medworm.com/index.php?rid=2576397&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F700%3Frss%3D1 Conclusions  Different ARMSs and their clinical outcomes may be reliably identified on an individual basis by assessing patterns of whole-brain neuroanatomical abnormalities. These patterns may serve as valuable biomarkers for the clinician to guide early detection in the prodromal phase of psychosis. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576397 Sun, 05 Jul 2009 23:00:00 +0100 2576397 http://www.medworm.com/index.php?rid=2576396&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F692%3Frss%3D1 Conclusions  Participants who received the Internet intervention for insomnia significantly improved their sleep, whereas the control group did not have a significant change. The Internet appears to have considerable potential in delivering a structured behavioral program for insomnia. Trial Registration  clinicaltrials.gov Identifier: NCT00328250 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576396 Sun, 05 Jul 2009 23:00:00 +0100 2576396 http://www.medworm.com/index.php?rid=2576395&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F691%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576395 Sun, 05 Jul 2009 23:00:00 +0100 2576395 http://www.medworm.com/index.php?rid=2576394&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F690%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576394 Sun, 05 Jul 2009 23:00:00 +0100 2576394 http://www.medworm.com/index.php?rid=2576393&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F7%2F686%3Frss%3D1 (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2576393 Sun, 05 Jul 2009 23:00:00 +0100 2576393 http://www.medworm.com/index.php?rid=2457657&cid=s_27087_172_f&fid=27087&url=http%3A%2F%2Farchpsyc.ama-assn.org%2Fcgi%2Fcontent%2Fshort%2F66%2F6%2F666%3Frss%3D1 Conclusions  These data suggest that higher β2*-nAChR availability persists up to 1 month of abstinence and normalizes to nonsmoker levels by 6 to 12 weeks of abstinence from tobacco smoking. These marked and persistent changes in β2*-nAChR availability may contribute to difficulties with tobacco cessation. (Source: Archives of General Psychiatry) Archives of General Psychiatry journals http://www.medworm.com/rss/comments.php?id=2457657 Mon, 01 Jun 2009 04:00:00 +0100 2457657