MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Archives of Pathology and Laboratory Medicine' source. Tue, 07 Feb 2012 06:39:40 +0100 http://www.medworm.com/index.php?rid=5640322&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22272560%26dopt%3DAbstract Conclusions.-More bona fide standards are needed to address the variety of available test methods, which have different performance characteristics including speed, sensitivity to detect rare mutations, and technical requirements. Refined standards addressing timing of KRAS testing, laboratory performance and accuracy, quality assurance and control, proper tissue collection, and appropriate result reporting would also be greatly beneficial. Pathologists should be aware that the amount of information they need to manage will increase, because future trends and technological advances will enhance the predictive power of diagnostic tests or the scope of the biomarker panels tested routinely across tumor types. PMID: 22272560 [PubMed - as supplied by publisher] (Source: Archives of Patholo... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5640322 Tue, 24 Jan 2012 05:00:00 +0100 5640322 http://www.medworm.com/index.php?rid=5578597&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22229848%26dopt%3DAbstract Conclusion.-Emerging evidence shows promise that biomarkers will be useful for predicting an individual patient's response to targeted therapy, leading to a more personalized approach to treating renal cell carcinoma. PMID: 22229848 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5578597 Mon, 09 Jan 2012 05:00:00 +0100 5578597 http://www.medworm.com/index.php?rid=5578596&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22229849%26dopt%3DAbstract Conclusion.-Gene testing of critical elements of the pathways targeted by these agents (such as KRAS mutational analysis in colorectal tumors and HER2/neu testing in gastric cancers) allows the ability to predict which patients will respond to these treatments. As the molecular profiling of tumors and our understanding of cancer genomics and epigenetic alterations continues to grow, it is expected that these personalized targeted therapies will form one of the mainstays of gastrointestinal cancer treatment. PMID: 22229849 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5578596 Mon, 09 Jan 2012 05:00:00 +0100 5578596 http://www.medworm.com/index.php?rid=5578595&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22229850%26dopt%3DAbstract Conclusions.-In gastrointestinal stromal tumors, the strongest predictor of response to targeted therapies is the mutational status of KIT or PDGFRA. Patients whose tumors harbor a KIT exon 11 mutation benefit the most from imatinib mesylate therapy, in terms of response rate, progression-free survival, and overall survival. Conversely, tumors without detectable mutations in either gene ("wild-type" gastrointestinal stromal tumors) are generally not responsive to imatinib mesylate. PMID: 22229850 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5578595 Mon, 09 Jan 2012 05:00:00 +0100 5578595 http://www.medworm.com/index.php?rid=5560708&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208481%26dopt%3DAbstract Authors: Halling KC, Schrijver I, Persons DL Abstract With our ever-increasing understanding of the molecular basis of disease, clinical laboratories are implementing a variety of molecular diagnostic tests to aid in the diagnosis of hereditary disorders, detection and monitoring of cancer, determination of prognosis and guidance for cancer therapy, and detection and monitoring of infectious diseases. Before introducing any new test into the clinical laboratory, the performance characteristics of the assay must be "verified," if it is a US Food and Drug Administration (FDA)-approved or FDA-cleared test, or "validated," if it is a laboratory-developed test. Although guidelines exist for how validation and verification studies may be addressed for molecular assays, the specific detai... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560708 Sun, 01 Jan 2012 05:00:00 +0100 5560708 http://www.medworm.com/index.php?rid=5560707&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208482%26dopt%3DAbstract Conclusions.-Protocols for verification of in vitro diagnostic assays may vary between laboratories. However, all laboratories must verify several specific performance specifications prior to implementation of such assays for clinical use. We provide an example of an approach used for verifying performance of an assay for cystic fibrosis carrier screening. PMID: 22208482 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560707 Sun, 01 Jan 2012 05:00:00 +0100 5560707 http://www.medworm.com/index.php?rid=5560706&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208483%26dopt%3DAbstract Conclusion.-Verification studies are required for FDA-approved diagnostic assays prior to use in patient care. Laboratories should develop a standardized approach to verification studies that can be adapted and applied to different types of assays. We describe the verification of an FDA-approved real-time polymerase chain reaction assay for the detection of a toxin gene in a bacterial pathogen. PMID: 22208483 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560706 Sun, 01 Jan 2012 05:00:00 +0100 5560706 http://www.medworm.com/index.php?rid=5560705&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208484%26dopt%3DAbstract Conclusions.-All clinical laboratories must establish several performance specifications mandated by the Clinical Laboratory Improvement Amendments of 1988 before implementation of any laboratory-developed test. Approaches to the validation of such assays may vary among laboratories. We describe an approach used for validation of a KRAS mutation-analysis assay by one laboratory. PMID: 22208484 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560705 Sun, 01 Jan 2012 05:00:00 +0100 5560705 http://www.medworm.com/index.php?rid=5560704&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208485%26dopt%3DAbstract Conclusions.-Validation of laboratory-developed quantitative molecular tests requires careful planning and execution to adequately address all required analytic performance parameters. How these are addressed depends on the potential for technical errors and confidence required for a given test result. We demonstrate how one laboratory validated and clinically implemented a quantitative BCR-ABL1 assay that can be used for the management of patients with chronic myelogenous leukemia. PMID: 22208485 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560704 Sun, 01 Jan 2012 05:00:00 +0100 5560704 http://www.medworm.com/index.php?rid=5560703&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208486%26dopt%3DAbstract Conclusion.-Protocols for validation of laboratory-developed sequencing assays may vary between laboratories. An example summary of a validation is provided. PMID: 22208486 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560703 Sun, 01 Jan 2012 05:00:00 +0100 5560703 http://www.medworm.com/index.php?rid=5560702&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208487%26dopt%3DAbstract Conclusions.-Protocols for initial validation of FISH assays may vary between laboratories. However, all laboratories must establish several defined performance specifications prior to implementation of FISH assays for clinical use. We describe an approach used for assessing performance specifications and validation of an analyte-specific reagent FISH assay using probes for MLL rearrangement in interphase nuclei. PMID: 22208487 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560702 Sun, 01 Jan 2012 05:00:00 +0100 5560702 http://www.medworm.com/index.php?rid=5560701&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208488%26dopt%3DAbstract Conclusions.-Participation in a multidisciplinary breast conference is useful in radiologic-pathologic correlation. Active involvement by pathologists in correlating pathologic and radiologic findings is important. PMID: 22208488 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560701 Sun, 01 Jan 2012 05:00:00 +0100 5560701 http://www.medworm.com/index.php?rid=5560700&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208489%26dopt%3DAbstract Conclusions.-Mesenchymal chondrosarcoma presents multiple challenges. Diagnostic pitfalls include inadequate biopsy samples, which may result in sample error. Sox9 has been proposed as a unique marker for mesenchymal chondrosarcoma which may improve diagnostic specificity. Treatment and prognosis vary considerably. Patients who receive surgery and chemotherapy seem to fare better. Multicenter studies with higher sample numbers may improve our understanding of this malignancy. PMID: 22208489 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560700 Sun, 01 Jan 2012 05:00:00 +0100 5560700 http://www.medworm.com/index.php?rid=5560699&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208490%26dopt%3DAbstract Conclusions.-Liquid-based cytology shows an almost complete elimination of most causes for unsatisfactory CP, with scant cellularity remaining as the sole cause for unsatisfactory LBC. On the other hand, with LBC a significant increase of smears without a transformation zone component was noted. Women with an unsatisfactory test result are not at increased risk for cervical abnormalities either with LBC or with CP. Trial Registration.-Nederlands Trial Register, NTR1032, www.trialregister.nl . PMID: 22208490 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560699 Sun, 01 Jan 2012 05:00:00 +0100 5560699 http://www.medworm.com/index.php?rid=5560698&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208491%26dopt%3DAbstract Conclusion.-Detection of FLT3 mutation is fast, easy, and inexpensive. The mutant to wild-type ratio is helpful for performing detailed risk stratification. DNA sequence analysis is more precise for confirming and evaluating the mutation pattern. PMID: 22208491 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560698 Sun, 01 Jan 2012 05:00:00 +0100 5560698 http://www.medworm.com/index.php?rid=5560697&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208492%26dopt%3DAbstract Conclusions.-There is a trend toward a decreasing supply of Canadian pathologists relative to that of cancer demands. This finding confirms an earlier population-based study showing a decreased supply relative to population and number of clinical physicians. It is uncertain whether this decreased supply is a result of appropriate application of new, efficient methods or whether health care has been rationed or adversely impacted. Outcome measures to monitor Canadian pathology practice quality are clearly needed. PMID: 22208492 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560697 Sun, 01 Jan 2012 05:00:00 +0100 5560697 http://www.medworm.com/index.php?rid=5560696&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208493%26dopt%3DAbstract Conclusions.-The low frequency (20%) of MDM2 amplification in our series of MPNSTs demonstrates that MDM2 fluorescent in situ hybridization has limited diagnostic value for the separation of benign schwannomas and MPNSTs. Our study demonstrated a positive correlation (P  =  .004) between MDM2 amplification and p53 expression. PMID: 22208493 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560696 Sun, 01 Jan 2012 05:00:00 +0100 5560696 http://www.medworm.com/index.php?rid=5560695&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208494%26dopt%3DAbstract Conclusions.-Assessment of treatment effect in pancreatic cancer is difficult. Pathologists need to be aware that some histologic features of treatment effect overlap with histologic features seen in untreated pancreatic cancer, such as tumor cell anaplasia, necrosis, and fibrosis. Careful assessment of pancreatic resections, including detailed gross examination and thorough histologic sampling, is important in accurately assessing treatment effect and improving patient outcomes. PMID: 22208494 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560695 Sun, 01 Jan 2012 05:00:00 +0100 5560695 http://www.medworm.com/index.php?rid=5560694&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208495%26dopt%3DAbstract Authors: Elgoweini M, Chetty R Abstract Benign vascular tumors arising primarily in lymph nodes are rare. The importance of identifying these entities is to avoid misdiagnosing them as malignant vascular tumors, which occur more often in lymph nodes. Hemangioma is a benign nodal vascular tumor, but its occurrence in lymph nodes is extremely rare. Hemangiomas can occur at any age, mostly in females. It is usually asymptomatic, affects only one node, and does not recur. Four histologic types of hemangioma have been identified: capillary/cavernous, lobular capillary, cellular, and epithelioid. This review highlights the key features of previously reported cases and discusses the differential diagnosis. PMID: 22208495 [PubMed - in process] (Source: Archives of Pathology and Laborat... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560694 Sun, 01 Jan 2012 05:00:00 +0100 5560694 http://www.medworm.com/index.php?rid=5560693&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208496%26dopt%3DAbstract Authors: Chekol SS, Sun CC Abstract Malignant mesothelioma of the tunica vaginalis testis is an extremely rare tumor representing 0.3% to 5% of all malignant mesotheliomas. Gross examination of testicular mesotheliomas typically reveals tumor nodules studding the thickened tunica vaginalis and, in some cases, infiltrating the testicular parenchyma, leading to diagnostic challenges. Microscopically, the tumor is characterized by epithelioid cells arising from the tunica vaginalis with papillary, tubulopapillary, or solid architectural patterns. The papillae are usually lined by a single layer of cells with relatively bland cytologic features. An epithelial cell phenotype admixed with a sarcomatoid pattern has also been described in a few cases. Immunohistochemically, the tumor is us... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5560693 Sun, 01 Jan 2012 05:00:00 +0100 5560693 http://www.medworm.com/index.php?rid=5535358&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22188200%26dopt%3DAbstract Conclusion.-Given the successes of novel compounds that target signaling pathways critical to the growth and survival of lymphoid tumor cells, the routine clinical use of molecularly targeted therapies for the treatment of lymphoid malignancies is likely in the near future. PMID: 22188200 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5535358 Thu, 22 Dec 2011 05:00:00 +0100 5535358 http://www.medworm.com/index.php?rid=5475534&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22136526%26dopt%3DAbstract Conclusions.-Evidence supporting this hypothesis is presented and potential mechanisms are discussed. A potential role for contributing cofactors is presented. PMID: 22136526 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475534 Fri, 02 Dec 2011 05:00:00 +0100 5475534 http://www.medworm.com/index.php?rid=5475557&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129172%26dopt%3DAbstract Authors: PMID: 22129172 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475557 Thu, 01 Dec 2011 05:00:00 +0100 5475557 http://www.medworm.com/index.php?rid=5475556&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129173%26dopt%3DAbstract Authors: Schwartz MR PMID: 22129173 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475556 Thu, 01 Dec 2011 05:00:00 +0100 5475556 http://www.medworm.com/index.php?rid=5475555&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129174%26dopt%3DAbstract Authors: Gurvits GE PMID: 22129174 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475555 Thu, 01 Dec 2011 05:00:00 +0100 5475555 http://www.medworm.com/index.php?rid=5475554&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129175%26dopt%3DAbstract Authors: Shimizu M, Nagata K PMID: 22129175 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475554 Thu, 01 Dec 2011 05:00:00 +0100 5475554 http://www.medworm.com/index.php?rid=5475553&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129176%26dopt%3DAbstract Authors: Chen Y, Watts G PMID: 22129176 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475553 Thu, 01 Dec 2011 05:00:00 +0100 5475553 http://www.medworm.com/index.php?rid=5475552&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129177%26dopt%3DAbstract Authors: Giasson J, Hernandez M, Chen Y PMID: 22129177 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475552 Thu, 01 Dec 2011 05:00:00 +0100 5475552 http://www.medworm.com/index.php?rid=5475551&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129178%26dopt%3DAbstract "Next-generation" pathology and laboratory medicine. Arch Pathol Lab Med. 2011 Dec;135(12):1531-2 Authors: Louis DN, Virgin HW, Asa SL PMID: 22129178 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475551 Thu, 01 Dec 2011 05:00:00 +0100 5475551 http://www.medworm.com/index.php?rid=5475550&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129179%26dopt%3DAbstract Conclusions.-Mucinous carcinoma in FNA was not accurately identified in a glass slide interlaboratory comparison program. We observed better performance with modified Giemsa-stained and ThinPrep slides than with Papanicolaou-stained preparations. The most common response for the benign category of mucinous carcinoma was fibroadenoma. Increased awareness of the cytologic features of mucinous carcinoma may improve accuracy in breast FNA. PMID: 22129179 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475550 Thu, 01 Dec 2011 05:00:00 +0100 5475550 http://www.medworm.com/index.php?rid=5475549&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129180%26dopt%3DAbstract Conclusion.-Defects in DNA MMR proteins are rare in pancreatic and small intestinal NETs, raising doubt that MSI plays a significant role in the pathogenesis of these tumors. PMID: 22129180 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475549 Thu, 01 Dec 2011 05:00:00 +0100 5475549 http://www.medworm.com/index.php?rid=5475548&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129181%26dopt%3DAbstract Conclusions.-Sensitivity and specificity of hrHPV test results associated with histopathologic follow-up diagnoses of VAIN 2/3 in patients with vaginal LSIL results were 100% and 21.2%, respectively. The positive predictive value of a vaginal hrHPV(+) LSIL result for a subsequent histopathologic VAIN 2/3 diagnosis was 14.6%. No cases of VAIN 2/3 were diagnosed in the 11 patients with vaginal hrHPV(-) LSIL results. Correlations of vaginal cytologic, histopathologic, and human papillomavirus findings were quite similar to correlation findings previously reported in older women with cervical LSIL test results. PMID: 22129181 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475548 Thu, 01 Dec 2011 05:00:00 +0100 5475548 http://www.medworm.com/index.php?rid=5475547&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129182%26dopt%3DAbstract Conclusions.-The study confirms a beneficial impact of the first 25 years of the dust standard established by the 1969 act on the prevalence and severity of coal worker's pneumoconiosis in US coal miners. However, pneumoconiosis continues to occur among miners who have worked entirely within the contemporary standard, suggesting a need for further reductions in exposure to respirable coal mine dust. PMID: 22129182 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475547 Thu, 01 Dec 2011 05:00:00 +0100 5475547 http://www.medworm.com/index.php?rid=5475546&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129183%26dopt%3DAbstract Conclusions.-These results provide the first evidence, to our knowledge, that experts are not immune to the effects of prevalence even with stimuli from their domain of expertise. Prevalence is a factor to consider in screening for disease by human observers and has significant implications for cytology-based cervical cancer screening in the post-human papillomavirus vaccine era, when prevalence rates of high-grade lesions in the population are expected to decline. PMID: 22129183 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475546 Thu, 01 Dec 2011 05:00:00 +0100 5475546 http://www.medworm.com/index.php?rid=5475545&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129184%26dopt%3DAbstract Conclusions.-Recognition of type(s) and source(s) of variation in biopsy fragment numbers is important in quality control and in the overall practical management of a histology laboratory. PMID: 22129184 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475545 Thu, 01 Dec 2011 05:00:00 +0100 5475545 http://www.medworm.com/index.php?rid=5475544&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129185%26dopt%3DAbstract Conclusions.-SCC of the renal pelvis/ureter is seen in a predominately female population in Sweden, is clinically aggressive, and has poor survival when presenting at an advanced stage in patients only treated by surgery. An immunostain panel serves as a useful adjunct in classifying these tumors. PMID: 22129185 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475544 Thu, 01 Dec 2011 05:00:00 +0100 5475544 http://www.medworm.com/index.php?rid=5475543&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129186%26dopt%3DAbstract Conclusions.-Anti-p53 combined with other conventional markers is helpful in increasing the sensitivity and specificity for detecting lung cancer. PMID: 22129186 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475543 Thu, 01 Dec 2011 05:00:00 +0100 5475543 http://www.medworm.com/index.php?rid=5475542&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129187%26dopt%3DAbstract Conclusion.-Reallocating staff to match the pattern of demand for phlebotomy collections throughout the day represents a strategy for improving the performance of an inpatient phlebotomy service. PMID: 22129187 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475542 Thu, 01 Dec 2011 05:00:00 +0100 5475542 http://www.medworm.com/index.php?rid=5475541&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129188%26dopt%3DAbstract Conclusions.-These results indicate that increased body mass index is a significant risk factor for the development of PTDM. However, none of the genetic polymorphisms studied confer predisposition to PTDM with the current sample size. PMID: 22129188 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475541 Thu, 01 Dec 2011 05:00:00 +0100 5475541 http://www.medworm.com/index.php?rid=5475540&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129189%26dopt%3DAbstract Meta-analysis of Clinical Studies of Diagnostic Tests: Developments in How the Receiver Operating Characteristic "Works". Arch Pathol Lab Med. 2011 Dec;135(12):1585-90 Authors: Hurley J Abstract Meta-analytic summaries are needed on clinical studies of diagnostic tests. Meta-analyses on clinical studies of diagnostic tests commonly use the receiver operating characteristic method, which differs conceptually and computationally from the more widely known meta-analytic methods applicable in other contexts, such as in studies of randomized controlled trials. Important conceptual differences for clinical studies of diagnostic tests versus randomized controlled trials are that the study subpopulations are not defined by random allocation and the test threshold typically varies a... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475540 Thu, 01 Dec 2011 05:00:00 +0100 5475540 http://www.medworm.com/index.php?rid=5475539&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129190%26dopt%3DAbstract Conclusion.-The contribution of the Treatise as the first formal textbook on the subject in America is seminal and should be the basis for further historic studies on the organization and structure of scientific knowledge in pathology in America. PMID: 22129190 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475539 Thu, 01 Dec 2011 05:00:00 +0100 5475539 http://www.medworm.com/index.php?rid=5475538&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129191%26dopt%3DAbstract We report a patient with initial thymus and pituitary gland involvement by RDD, who later developed papules on the groin and axilla. Skin biopsies showed admixed histiocytic infiltrates (lymphocytes, neutrophils, and plasma cells) without emperipolesis. A prominent eosinophilic infiltrate was also observed, a feature not, to our knowledge, previously reported. Immunohistochemistry revealed positivity for CD68 (most cells) and S100 protein (scattered cells) and was negative for anti-CD1a. The diagnosis of RDD was established in the clinical context after comparison with the thymic and pituitary lesions (similar histologic features, albeit with fewer eosinophils, and immunohistochemical profiles). We present the first case, to our knowledge, of multicentric RDD with cutaneous involvement and... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475538 Thu, 01 Dec 2011 05:00:00 +0100 5475538 http://www.medworm.com/index.php?rid=5475537&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129192%26dopt%3DAbstract Authors: Roy S, Parwani AV Abstract Primary adenocarcinoma of urinary bladder is an uncommon neoplasm and is a source of diagnostic confusion with adenocarcinomas arising in adjacent organs, especially colon. These tumors show varied histologic picture and degree of differentiation. Clinical association with bladder exstrophy and schistosomiasis has been well documented. Primary bladder adenocarcinomas have overlapping histologic and immunohistochemical features with adenocarcinomas arising from other primary sites and the suggested immunohistochemical panel includes cytokeratins 7 and 20, 34βE12, thrombomodulin, CDX2, and β-catenin. Clinical, imaging, histologic, and immunohistochemical correlation should be done while rendering this diagnosis, as prognosis and therapeutic optio... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475537 Thu, 01 Dec 2011 05:00:00 +0100 5475537 http://www.medworm.com/index.php?rid=5475536&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129193%26dopt%3DAbstract Authors: Vasudev P, Onuma K Abstract Secretory carcinoma is a rare but distinct subtype of breast carcinoma, with characteristic histomorphology and generally favorable prognosis. Although it was originally described as a juvenile breast carcinoma, occurring in young children, most cases have been reported in adults of both sexes. As the name implies, the characteristic histomorphology is the presence of a large amount of intracellular and extracellular, eosinophilic secretion material that stains positive for periodic acid-Schiff. Most tumors stain positive for S100 and negative for estrogen receptor, progesterone receptor, and ERBB2 (formerly HER2/neu) (ie, triple negative). In addition, some secretory carcinomas demonstrate a basal-like immunoprofile. Recent studies have shown t... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475536 Thu, 01 Dec 2011 05:00:00 +0100 5475536 http://www.medworm.com/index.php?rid=5475535&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22129194%26dopt%3DAbstract We present a review of the literature pertaining to squamous lesions of the ovary. In particular, we summarize the relevant clinical features, workup, gross findings and histopathologic features, differential diagnosis, treatment, and prognostic features of both the common and rare squamous entities found in the ovary. PMID: 22129194 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5475535 Thu, 01 Dec 2011 05:00:00 +0100 5475535 http://www.medworm.com/index.php?rid=5380161&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032558%26dopt%3DAbstract Authors: Abstract An article by Suryawanshi et al that appears in the August 2011 issue of the Archives (Suryawanshi P, Ramadwar M, Dikshit R, et al. A Study of Pathologic Risk Factors in Postchemoreduced, Enucleated Specimens of Advanced Retinoblastomas in a Developing Country. Arch Pathol Lab Med. 2011;135[8]:1017-1023 ) lists an incorrect e-mail address for the corresponding author. The correct e-mail address for Dr. Viswanathan is drseetha.v@gmail.com . PMID: 22032558 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380161 Tue, 01 Nov 2011 04:00:00 +0100 5380161 http://www.medworm.com/index.php?rid=5380160&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032559%26dopt%3DAbstract Authors: Toll A PMID: 22032559 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380160 Tue, 01 Nov 2011 04:00:00 +0100 5380160 http://www.medworm.com/index.php?rid=5380159&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032560%26dopt%3DAbstract Authors: Rabinovitch A PMID: 22032560 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380159 Tue, 01 Nov 2011 04:00:00 +0100 5380159 http://www.medworm.com/index.php?rid=5380158&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032561%26dopt%3DAbstract Authors: Allen TC Abstract The College of American Pathologists (CAP) is dedicated to pathology and laboratory medicine quality. The CAP's Laboratory Accreditation Program, Proficiency Testing Program, Q-Probes and Q-Tracks, site-specific cancer checklists, webinars, annual meetings, and Advanced Practical Pathology series are all focused on providing superior patient quality. The CAP is synonymous with quality in pathology and laboratory medicine. As pathology practice becomes more sophisticated, the CAP's many programs will increasingly help pathologists provide appropriate, personalized care. PMID: 22032561 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380158 Tue, 01 Nov 2011 04:00:00 +0100 5380158 http://www.medworm.com/index.php?rid=5380157&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032562%26dopt%3DAbstract Conclusions.-To maintain their high standard of excellence, cytologists should seek to define the most appropriate way to incorporate this new information into their interpretation of individual cases. PMID: 22032562 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380157 Tue, 01 Nov 2011 04:00:00 +0100 5380157 http://www.medworm.com/index.php?rid=5380156&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032563%26dopt%3DAbstract Conclusions.-There is considerable disagreement between pathologists and nonpathologists concerning which diagnoses are critical values in anatomic pathology. Use of the term treatable immediately, life threatening significantly improves agreement. PMID: 22032563 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380156 Tue, 01 Nov 2011 04:00:00 +0100 5380156 http://www.medworm.com/index.php?rid=5380155&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032564%26dopt%3DAbstract Conclusions.-Achieving quality communication in surgical pathology is dependent on pathologists addressing multiple situations including managing physicians' expectations for turnaround time and ancillary testing, understanding what information is needed to manage the patient at intraoperative consultation and in the final report, assuring adequate report content with the use of synoptic checklist reports, and using report formatting suggestions that aid report comprehension. Finally, the pathologists' availability to answer questions and discuss cases is an important factor in effective communication, including their willingness to verbally report urgent and significant unexpected diagnoses to ensure that important diagnoses are not overlooked. PMID: 22032564 [PubMed - in process] (So... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380155 Tue, 01 Nov 2011 04:00:00 +0100 5380155 http://www.medworm.com/index.php?rid=5380154&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032565%26dopt%3DAbstract Conclusions.-Evidence-based medicine holds the promise of optimizing laboratory services to produce "quality" practices in pathology. It will also be a key to restraining the overall cost of health care. PMID: 22032565 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380154 Tue, 01 Nov 2011 04:00:00 +0100 5380154 http://www.medworm.com/index.php?rid=5380153&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032566%26dopt%3DAbstract Conclusions.-Federal and state regulations, along with accreditation standards developed by the College of American Pathologists and The Joint Commission, have established guidelines for the performance of POCT and have provided a strong incentive to improve the quality of testing. Many instruments for POCT have incorporated advanced design features to prevent analytic and operator errors. This, along with the development of connectivity standards and specialized data management software, has enabled remote review of test data and electronic flow of information to hospital information systems. However, documentation of manually performed, visually read tests remains problematic and some POCT devices do not have adequate safeguards to prevent significant errors. In the past 2 decades the st... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380153 Tue, 01 Nov 2011 04:00:00 +0100 5380153 http://www.medworm.com/index.php?rid=5380152&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032567%26dopt%3DAbstract Conclusions.-Active reporting, structured investigation, and systematic resolution of transfusion-related errors are effective methods for improving and maintaining transfusion quality. PMID: 22032567 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380152 Tue, 01 Nov 2011 04:00:00 +0100 5380152 http://www.medworm.com/index.php?rid=5380151&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032568%26dopt%3DAbstract Conclusions.-Quality and safety have always been of prime importance in medicine. However, in the future, under health care reform and associated initiatives, a shift in the paradigm of medicine will integrate quality and safety measurement with financial incentives and a new emphasis on consumerism. PMID: 22032568 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380151 Tue, 01 Nov 2011 04:00:00 +0100 5380151 http://www.medworm.com/index.php?rid=5380150&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032569%26dopt%3DAbstract Conclusion.-The College of American Pathologists is a leader in laboratory quality and has unique insights into the benefits and risks to patients presented by LDTs. Continued dialog with officials from the FDA and CMS will promote public and private collaborative efforts to assure innovation of diagnostic testing, public information, and patient safety for clinical diagnostic testing. PMID: 22032569 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380150 Tue, 01 Nov 2011 04:00:00 +0100 5380150 http://www.medworm.com/index.php?rid=5380149&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032570%26dopt%3DAbstract Conclusion.-We conclude that the increased focus on surgical pathology near-miss events will reveal latent factors that may be targeted for improvement. PMID: 22032570 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380149 Tue, 01 Nov 2011 04:00:00 +0100 5380149 http://www.medworm.com/index.php?rid=5380148&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032571%26dopt%3DAbstract Authors: Allen TC, Hammond ME, Robboy SJ Abstract The College of American Pathologists (CAP) is dedicated to pathology and laboratory medicine quality. The CAP's Laboratory Accreditation Program, Proficiency Testing Program, Q-Probes and Q-Tracks, site-specific cancer checklists, webinars, annual meetings, and Advanced Practical Pathology series are all focused on providing superior patent quality. The CAP is synonymous with quality in pathology and laboratory medicine. As pathology practice becomes more sophisticated, the CAP's many programs will increasingly help pathologists provide appropriate, personalized patient care. PMID: 22032571 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380148 Tue, 01 Nov 2011 04:00:00 +0100 5380148 http://www.medworm.com/index.php?rid=5380147&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032572%26dopt%3DAbstract Conclusions.-The failure rate is decreasing for all participants. The failures for primary pathologist screeners are due to false-positive responses. Primary screening cytotechnologists and secondary pathologists have automatic failures more often than do primary screening pathologists. PMID: 22032572 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380147 Tue, 01 Nov 2011 04:00:00 +0100 5380147 http://www.medworm.com/index.php?rid=5380146&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032573%26dopt%3DAbstract Conclusions.-Human epidermal growth factor receptor 2 testing in gastroesophageal cancer can be performed using standard breast cancer procedures and the American Society of Clinical Oncology/College of American Pathologists scoring criteria. Although IHC 0 and IHC 3+ provide clear stratification, reliable separation of IHC 1+ and IHC 2+ may be difficult, especially in biopsy samples. The latter 2 groups are best referred to FISH for definitive classification. PMID: 22032573 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380146 Tue, 01 Nov 2011 04:00:00 +0100 5380146 http://www.medworm.com/index.php?rid=5380145&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032574%26dopt%3DAbstract Conclusions.-In VC we recommend: embed and process any remaining prostatic tissue including any saved fresh-frozen tissue; obtain 3 levels of each paraffin block; if results are negative, melt and flip the tissue and obtain 3 more levels. Following the above guidelines, a hidden carcinoma may be detected in the majority of the cases of VC. PMID: 22032574 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380145 Tue, 01 Nov 2011 04:00:00 +0100 5380145 http://www.medworm.com/index.php?rid=5380144&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032575%26dopt%3DAbstract Conclusions.-Completeness of reporting, irrespective of subspecialist interest, was dramatically increased by the use of a synoptic report. Improvements in completeness were most pronounced among nongastrointestinal pathologists, enabling them to attain a level of report completeness comparable to that of gastrointestinal pathologists. Further studies are required to determine whether there are actual discrepancies in the detection of prognostic features between specialist gastrointestinal and nongastrointestinal pathologists. PMID: 22032575 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380144 Tue, 01 Nov 2011 04:00:00 +0100 5380144 http://www.medworm.com/index.php?rid=5380143&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032576%26dopt%3DAbstract Conclusions.-Voice recognition technology allows for a seamless workflow in surgical pathology, with improvements in turnaround time and a positive impact on competency-based resident education. Individual practices may assess the value of VRT and decide to implement it, potentially with gains in many aspects of their practice. PMID: 22032576 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380143 Tue, 01 Nov 2011 04:00:00 +0100 5380143 http://www.medworm.com/index.php?rid=5380142&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032577%26dopt%3DAbstract Conclusion.-Endothelial dysfunction is present in SLE patients even in the absence of traditional cardiovascular risk factors due to disease activity. PMID: 22032577 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380142 Tue, 01 Nov 2011 04:00:00 +0100 5380142 http://www.medworm.com/index.php?rid=5380141&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032578%26dopt%3DAbstract Conclusions.-Prostate-specific membrane antigen is expressed in the vasculature of GBM vessels, thus rendering a potential novel therapeutic vascular target. A clinical trial with a cytotoxin-conjugated antibody to PSMA is planned. PMID: 22032578 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380141 Tue, 01 Nov 2011 04:00:00 +0100 5380141 http://www.medworm.com/index.php?rid=5380140&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032579%26dopt%3DAbstract Conclusions.-Each of these infectious lymphadenitides had distinct epidemiologic and histopathologic features that are discussed in this report. PMID: 22032579 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380140 Tue, 01 Nov 2011 04:00:00 +0100 5380140 http://www.medworm.com/index.php?rid=5380139&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032580%26dopt%3DAbstract Authors: Davis BN, Karabakhtsian RG, Pettigrew AL, Arnold SM, French CA, Musgrave Brill Y Abstract A 54-year-old woman presented with a nasal mass. Biopsy demonstrated undifferentiated tumor cells with extensive apoptosis and necrosis. Chromosome analysis identified a 46,XX,t(15;19)(q13;p13.1) pattern. Nuclear protein in testis (NUT) immunohistochemistry and fluorescence in situ hybridization confirmed NUT rearrangement. A Ewing sarcoma-based chemotherapy regimen and concurrent irradiation obtained a dramatic response; however, the patient died of her disease less than 7 months after initial diagnosis. NUT midline carcinomas are rare, aggressive tumors defined by rearrangement of the NUT gene on 15q14. A solitary translocation involving 15q14 is usually the sole chromosomal abnorm... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380139 Tue, 01 Nov 2011 04:00:00 +0100 5380139 http://www.medworm.com/index.php?rid=5380138&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032581%26dopt%3DAbstract Authors: Toribio Y, Roehrl MH Abstract Nasolabial cysts are interesting, relatively uncommon benign extraosseous maxillary lesions. We review current knowledge about epidemiology, symptoms, imaging modalities, pathogenesis, histopathologic and ultrastructural features, treatment options, and prognosis. Nasolabial cyst lining epithelium is characteristically composed of a basal layer of cuboidal cells and a luminal layer of columnar secretory cells with interspersed mucous goblet cells. In addition, areas of multilayered epithelium and squamous metaplasia may be seen. The cyst stroma is characterized by collagen-rich fibrovascular tissue with variably admixed chronic inflammatory cells. Furthermore, to our knowledge, we report the first example of immunohistochemical protein express... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380138 Tue, 01 Nov 2011 04:00:00 +0100 5380138 http://www.medworm.com/index.php?rid=5380137&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22032582%26dopt%3DAbstract Authors: Sangle NA, Perkins SL Abstract Core-binding factor acute myeloid leukemia (AML) is cytogenetically defined by the presence of t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22), commonly abbreviated as t(8;21) and inv(16), respectively. In both subtypes, the cytogenetic rearrangements disrupt genes that encode subunits of core-binding factor, a transcription factor that functions as an essential regulator of normal hematopoiesis. The rearrangements t(8;21) and inv(16) involve the RUNX1/RUNX1T1 ( AML1-ETO ) and CBFB/MYH11 genes, respectively. These 2 subtypes are categorized as AML with recurrent genetic abnormalities, and hence the cytogenetic fusion transcripts are considered diagnostic of acute leukemia even when the marrow blast count is less than 20%. The t(8;21) an... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380137 Tue, 01 Nov 2011 04:00:00 +0100 5380137 http://www.medworm.com/index.php?rid=5380162&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21992705%26dopt%3DAbstract Conclusions.-Each institution should create its own policy regarding urgent diagnoses and significant, unexpected diagnoses in anatomic pathology. This policy should be separate from critical results or panic-value policies in clinical pathology, with the expectation of a different time frame for communication. Urgent diagnosis is defined as a medical condition that, in most cases, should be addressed as soon as possible. Significant, unexpected diagnosis is defined as a medical condition that is clinically unusual or unforeseen and should be addressed at some point in the patient's course. Further details of this statement are provided. PMID: 21992705 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5380162 Thu, 13 Oct 2011 04:00:00 +0100 5380162 http://www.medworm.com/index.php?rid=5298147&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970474%26dopt%3DAbstract Authors: Abstract Notice of Failure to Disclose Financial Interest: "Update on Fluorescence In Situ Hybridization in Melanoma: State of the Art" ( Arch Pathol Lab Med. 2011;135[7]:830-837 ). Pedram Gerami, MD, has done consultant work for both NeoGenomics and Abbott Molecular Labs and has received honoraria from these companies. PMID: 21970474 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298147 Sat, 01 Oct 2011 04:00:00 +0100 5298147 http://www.medworm.com/index.php?rid=5298146&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970475%26dopt%3DAbstract Authors: PMID: 21970475 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298146 Sat, 01 Oct 2011 04:00:00 +0100 5298146 http://www.medworm.com/index.php?rid=5298145&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970476%26dopt%3DAbstract Authors: Dacic S PMID: 21970476 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298145 Sat, 01 Oct 2011 04:00:00 +0100 5298145 http://www.medworm.com/index.php?rid=5298144&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970477%26dopt%3DAbstract Authors: Green R PMID: 21970477 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298144 Sat, 01 Oct 2011 04:00:00 +0100 5298144 http://www.medworm.com/index.php?rid=5298143&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970478%26dopt%3DAbstract "No pay, no play": the end of professional ethics in pathology? Arch Pathol Lab Med. 2011 Oct;135(10):1246 Authors: Hernandez JS PMID: 21970478 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298143 Sat, 01 Oct 2011 04:00:00 +0100 5298143 http://www.medworm.com/index.php?rid=5298142&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970479%26dopt%3DAbstract Authors: Yantiss RK PMID: 21970479 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298142 Sat, 01 Oct 2011 04:00:00 +0100 5298142 http://www.medworm.com/index.php?rid=5298141&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970480%26dopt%3DAbstract Conclusions.-In spite of interobserver variability, histologic assessment of dysplasia is currently the accepted method of surveillance, and subsequent patient management is dictated by this evaluation. Although not universal, endoscopic therapy is increasingly important in replacing esophagectomy for patients with high-grade dysplasia or early carcinoma. PMID: 21970480 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298141 Sat, 01 Oct 2011 04:00:00 +0100 5298141 http://www.medworm.com/index.php?rid=5298140&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970481%26dopt%3DAbstract Conclusions.-Many studies have contributed to an increased understanding of the natural progression of mucinous neoplasms of the appendix and peritoneum, and the adoption of a uniform reporting system, as advocated by the American Joint Committee on Cancer and the World Health Organization, will facilitate clear communication among pathologists and clinical colleagues. PMID: 21970481 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298140 Sat, 01 Oct 2011 04:00:00 +0100 5298140 http://www.medworm.com/index.php?rid=5298139&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970482%26dopt%3DAbstract Conclusions.-Universal screening for Lynch syndrome in all individuals affected with colorectal cancer has been recommended by the Evaluation of Genomic Applications in Practice and Prevention Working Group. Preliminary screening tests can identify individuals unlikely to be affected by Lynch syndrome, thereby reducing the need for full gene analysis. Immunohistochemistry and polymerase chain reaction-based tests for microsatellite instability have similar clinical sensitivity and specificity, and each method has advantages and limitations. BRAF and MLH1 methylation testing are useful reflex tests for those with a defect in MLH1 identified by immunohistochemistry. Emerging technologies, such as high-throughput sequencing, may substantially affect diagnostic algorithms in the future. PM... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298139 Sat, 01 Oct 2011 04:00:00 +0100 5298139 http://www.medworm.com/index.php?rid=5298138&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970483%26dopt%3DAbstract Conclusions.-Molecular analysis of colorectal cancer is now mandated before initiation of anti-EGFR therapy and directly impacts treatment options and outcomes. Familiarity with the mutations that determine utility and efficacy of therapy, as well as the importance of careful sample selection, will facilitate appropriate testing and optimize patient care. PMID: 21970483 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298138 Sat, 01 Oct 2011 04:00:00 +0100 5298138 http://www.medworm.com/index.php?rid=5298137&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970484%26dopt%3DAbstract Conclusions.-Most gastrointestinal lymphomas are readily amenable to an unqualified diagnosis, primarily those cases consisting of monomorphic large cells whether of B- or T-cell lineage, including cases associated with enteropathy. Diagnosis for infiltrates dominated by small lymphocytes remains taxing, as the differential diagnosis embraces not only MALT lymphoma and lymphoid hyperplasia but also mantle cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia/small lymphocytic lymphoma. Adherence to strict morphologic criteria is the standard for diagnosis, but these criteria should be augmented by immunologic studies together with judicious use of molecular techniques to determine clonality. In establishing a diagnosis of gastric marginal zone lymphoma of MALT type, determin... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298137 Sat, 01 Oct 2011 04:00:00 +0100 5298137 http://www.medworm.com/index.php?rid=5298136&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970485%26dopt%3DAbstract Conclusions.-The discovery of the KIT -GIST connection has not only improved the diagnostic accuracy of GISTs but also provided us with a better understanding of the histogenesis and molecular pathogenesis of these neoplasms. PMID: 21970485 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298136 Sat, 01 Oct 2011 04:00:00 +0100 5298136 http://www.medworm.com/index.php?rid=5298135&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970486%26dopt%3DAbstract Conclusions.-These polyps do surface every so often. There is significant literature covering inflammatory fibroid polyps and granular cell tumors, but there is little literature about the other entities. PMID: 21970486 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298135 Sat, 01 Oct 2011 04:00:00 +0100 5298135 http://www.medworm.com/index.php?rid=5298134&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970487%26dopt%3DAbstract Conclusions.-The evaluation of liver biopsies with chronic viral hepatitis has evolved beyond grading and staging. Pathologists need to be aware of the other features that may have important clinical implications. PMID: 21970487 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298134 Sat, 01 Oct 2011 04:00:00 +0100 5298134 http://www.medworm.com/index.php?rid=5298133&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970488%26dopt%3DAbstract Conclusion.-The upcoming International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification of lung adenocarcinoma is relevant in that it shows a phenotype-genotype correlation. Comprehensive histologic subtyping should be recommended because of the association of particular subtypes with epidermal growth factor receptor mutations. PMID: 21970488 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298133 Sat, 01 Oct 2011 04:00:00 +0100 5298133 http://www.medworm.com/index.php?rid=5298132&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970489%26dopt%3DAbstract Conclusions.-This study demonstrates a simple, efficient, and cost-effective method to reduce autofluorescence using Sudan black B, and also provides a comprehensive approach to identify and minimize autofluorescence of renal tissue. PMID: 21970489 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298132 Sat, 01 Oct 2011 04:00:00 +0100 5298132 http://www.medworm.com/index.php?rid=5298131&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970490%26dopt%3DAbstract Conclusions.-Confocal laser endomicroscopy is proving its ability to provide histology-like images of tissues in vivo to help avoid risks and costs of conventional biopsies. Confocal imaging restricts light to 1 plane, emulating a paraffin section, and topical or systemic optical contrast agents allow subcellular resolution. New contrast agents could theoretically permit molecular characterization. In vivo imaging has begun to demonstrate novel, dynamic types of diagnostic features. Decreased histologic biopsies can be anticipated for a few scenarios. Significant limitations of CLE include the inability to create a tissue archive for broad molecular classification, suboptimal contrast agents, small fields of view and shallow penetration, paucity of clinical validation studies, and problems... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298131 Sat, 01 Oct 2011 04:00:00 +0100 5298131 http://www.medworm.com/index.php?rid=5298130&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970491%26dopt%3DAbstract Conclusions.-In the UPMC pathology program, 2-digit scores on USMLE step 1 of 90 or more and 80 or less were strong measures of ABP first-time pass/failure rates, whereas scores of 81 to 89 were less-accurate measures. The USMLE step 1 score is one of many criteria that can be used for screening applicants for a pathology residency program. PMID: 21970491 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298130 Sat, 01 Oct 2011 04:00:00 +0100 5298130 http://www.medworm.com/index.php?rid=5298129&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970492%26dopt%3DAbstract Authors: Lagana SM, Hanna RF, Borczuk AC Abstract Solitary papillomas of the bronchial tree are rare, particularly in the distal airways. When encountered, solitary papillomas are not frequently found to undergo malignant transformation. When this does happen, it is usually a squamous cell carcinoma arising in a human papillomavirus-associated squamous papilloma (usually in a central airway). Here we report a unique case of pleomorphic (spindle and squamous cell) carcinoma arising in a mixed glandular and squamous papilloma without human papillomavirus association. PMID: 21970492 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298129 Sat, 01 Oct 2011 04:00:00 +0100 5298129 http://www.medworm.com/index.php?rid=5298128&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970493%26dopt%3DAbstract Authors: Chisholm C, Lopez L Abstract The herpes family of viruses accounts for a significant proportion of human cutaneous disease. Although most episodes of viral infection can be diagnosed clinically, a small subset of these outbreaks will require biopsy for histologic interpretation and diagnosis. Most herpesviruses cause characteristic architectural and cytologic changes in the context of active infection, whereas the effects of some will not manifest until the future as malignant disease. Other infections may go unnoticed secondary to a lack of specific histologic findings. Because herpesviruses cause such a wide spectrum of cutaneous conditions, it is prudent that pathologists be aware of the varied clinical and histopathologic presentations so that these infections will not... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298128 Sat, 01 Oct 2011 04:00:00 +0100 5298128 http://www.medworm.com/index.php?rid=5298127&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970494%26dopt%3DAbstract Authors: Horne MJ, Adeniran AJ Abstract In this short review, we discuss primary diffuse large B-cell lymphoma of the testis, an entity that is most commonly seen in older patients. The most common clinical presentation is a unilateral testicular mass. Microscopically, the tumor shows diffuse infiltration of lymphocytes between intact seminiferous tubules. Spermatogenic arrest, interstitial fibrosis, and tubular hyalinization are commonly seen. The tumor is positive for B-cell markers by immunohistochemistry. Treatment has traditionally been with orchiectomy and combination chemotherapy; however, only a minority of patients enjoy a prolonged disease-free survival. Differential diagnosis includes seminoma and viral and granulomatous orchitis. PMID: 21970494 [PubMed - in process]... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298127 Sat, 01 Oct 2011 04:00:00 +0100 5298127 http://www.medworm.com/index.php?rid=5298126&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21970495%26dopt%3DAbstract Book Review The Handbook of Biomarkers By Kewal K . Jain , 492 pp , Secaucus, New Jersey , Humana Press/Springer , 2010 . Arch Pathol Lab Med. 2011 Oct;135(10):1368 Authors: Borczuk AC PMID: 21970495 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5298126 Sat, 01 Oct 2011 04:00:00 +0100 5298126 http://www.medworm.com/index.php?rid=5193063&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21877988%26dopt%3DAbstract Authors: Austin RM, Zhao C PMID: 21877988 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5193063 Wed, 31 Aug 2011 23:00:00 +0100 5193063 http://www.medworm.com/index.php?rid=5193062&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21877989%26dopt%3DAbstract Conclusions.-Differences were observed for the gel separator specific gravity in different blood collection containers. Laboratories wishing to avoid problems with inappropriate gel flotation in high protein samples should consider these observations. PMID: 21877989 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5193062 Wed, 31 Aug 2011 23:00:00 +0100 5193062 http://www.medworm.com/index.php?rid=5193061&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21877990%26dopt%3DAbstract This report supports one other case report that Malassezia species may cause granulomatous dermatitis; in the previous case, the etiologic agent was Malassezia pachydermatis , a nonlipid-dependent species. We recommend the use of lipid-supplemented culture media for specimens from patients with granulomatous dermatitis because several Malassezia species are dependent on lipid; the absence of lipid supplementation in routine cultures likely explains the negative culture results for this patient. This, to our knowledge, is the first report of granulomatous dermatitis caused by M sympodialis. PMID: 21877990 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5193061 Wed, 31 Aug 2011 23:00:00 +0100 5193061 http://www.medworm.com/index.php?rid=5193060&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21877991%26dopt%3DAbstract Authors: Kim HJ, Yoo YS, Park K, Kwon JE, Kim JY, Monzon FA Abstract Carcinoma arising from Warthin tumor is extremely rare. A 79-year-old man was admitted for a firm, well-defined, 5-cm left infra-auricular mass. Aspiration cytology showed many lymphohistiocytes and oncocytes in a proteinaceous background, compatible with Warthin tumor. A left superficial parotidectomy showed a solid mass around the cyst wall. The tumor cells of the solid area were arranged as infiltrative ducts with a few foci of malignant transformation. Virtual karyotyping disclosed a complex pattern of genetic aberrations with a focal amplification in 12q14-q21.2. This chromosomal region contains the MDM2 (murine double minute) gene, which regulates p53 inactivation. HER2 fluorescence in situ hybridization sho... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5193060 Wed, 31 Aug 2011 23:00:00 +0100 5193060 http://www.medworm.com/index.php?rid=5193059&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21877992%26dopt%3DAbstract Authors: Sangle NA, Smock KJ Abstract Antiphospholipid antibodies are directed against phospholipid-protein complexes and include lupus anticoagulant, anticardiolipin antibodies, and anti-beta-2 glycoprotein I antibodies. Antiphospholipid antibody syndrome is a common cause of acquired thrombophilia and is characterized by venous or arterial thromboembolism or pregnancy morbidity and the presence of antiphospholipid antibodies. Antibodies should be demonstrable on at least 2 occasions separated by 12 weeks. Heterogeneity of the autoantibodies and absence of gold standard assays makes interpretation of laboratory results a challenge for both laboratorians and clinicians. This review discusses the key laboratory and clinical aspects of antiphospholipid antibody syndrome. Particular ... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5193059 Wed, 31 Aug 2011 23:00:00 +0100 5193059 http://www.medworm.com/index.php?rid=5193058&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21877993%26dopt%3DAbstract Authors: Mohammadi A, Rosa M Abstract Choriocarcinomatous differentiation has been described in tumors arising from many organs including lung, rectum, colon, stomach, bladder, and rarely breast. Mammary carcinoma with choriocarcinomatous features is a rare variant of breast metaplastic carcinoma characterized by malignant cells morphologically resembling choriocarcinoma cells in which reactivity with human placental lactogen and human chorionic gonadotropin can be demonstrated by immunohistochemistry. The characteristic syncytiotrophoblast-like giant cells seen in these neoplasms are more commonly associated with moderately to poorly differentiated carcinomas with or without a clear-cut mesenchymal component. Most of the reported cases have behaved very aggressively. The reason fo... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5193058 Wed, 31 Aug 2011 23:00:00 +0100 5193058 http://www.medworm.com/index.php?rid=5193057&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21877994%26dopt%3DAbstract Authors: PMID: 21877994 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5193057 Wed, 31 Aug 2011 23:00:00 +0100 5193057 http://www.medworm.com/index.php?rid=5193056&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21877995%26dopt%3DAbstract Authors: PMID: 21877995 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5193056 Wed, 31 Aug 2011 23:00:00 +0100 5193056 http://www.medworm.com/index.php?rid=5193055&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21882964%26dopt%3DAbstract Conclusions.-Rapid genome sequence analysis permitted us to genetically define this strain, rule out the likelihood of bioterrorism, and contribute effectively to the institutional response to this event. Our experience strongly reinforced the critical value of deploying a well-integrated, anatomic, clinical, and genomic strategy to respond rapidly to a potential emerging, infectious threat to public health. PMID: 21882964 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5193055 Mon, 08 Aug 2011 23:00:00 +0100 5193055 http://www.medworm.com/index.php?rid=5104113&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809983%26dopt%3DAbstract Authors: Lewin-Smith MR, Kalasinsky VF, Mullick FG PMID: 21809983 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104113 Sun, 31 Jul 2011 23:00:00 +0100 5104113 http://www.medworm.com/index.php?rid=5104112&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809984%26dopt%3DAbstract Authors: Sigdel S, Gemind JT, Tomashefski JF PMID: 21809984 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104112 Sun, 31 Jul 2011 23:00:00 +0100 5104112 http://www.medworm.com/index.php?rid=5104111&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809985%26dopt%3DAbstract Authors: Kaur P PMID: 21809985 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104111 Sun, 31 Jul 2011 23:00:00 +0100 5104111 http://www.medworm.com/index.php?rid=5104110&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809986%26dopt%3DAbstract Authors: Cagle PT, Dacic S, Allen TC PMID: 21809986 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104110 Sun, 31 Jul 2011 23:00:00 +0100 5104110 http://www.medworm.com/index.php?rid=5104109&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809987%26dopt%3DAbstract Conclusions.-This study quantified mislabeling rates across 136 institutions of cases (0.11%), specimens (0.1%), blocks (0.17%), and slides (0.11%). Errors in labeling appear nearly equally throughout the system of accessioning, gross pathology processing, and tissue cutting. Errors are typically detected in the immediate steps after the errors occurred, reinforcing the need for quality checks throughout the system. PMID: 21809987 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104109 Sun, 31 Jul 2011 23:00:00 +0100 5104109 http://www.medworm.com/index.php?rid=5104108&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809988%26dopt%3DAbstract Conclusions.-Together, these 5 IHC stains were combined to make a panel that was 100% sensitive and 91% specific in distinguishing between CMBC and SGC. PMID: 21809988 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104108 Sun, 31 Jul 2011 23:00:00 +0100 5104108 http://www.medworm.com/index.php?rid=5104107&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809989%26dopt%3DAbstract Conclusion.-Distinguishing AT/RT from MBs is clinically important. For expert neuropathologists, the diagnoses of AT/RT and MB can be reliably made from hematoxylin-eosin stains in the vast majority of cases. However certain rare small cell variants of AT/RT can be confused with MB. We also found that immunohistochemical reactivity for BAF47 is clinically useful in distinguishing MBs from AT/RTs and for identifying certain small cell AT/RTs. Among MBs, nodularity may be an important prognostic factor for improved PFS and OS in infants and children. PMID: 21809989 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104107 Sun, 31 Jul 2011 23:00:00 +0100 5104107 http://www.medworm.com/index.php?rid=5104106&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809990%26dopt%3DAbstract Conclusions.-Given the higher analytical sensitivity and specificity of the qPCR assay, that assay is less likely to generate equivocal results than the capillary electrophoresis assay. Moreover, the qPCR assay is quantitative, faster, cheaper, less prone to contamination, and well suited for monitoring minimal residual disease. PMID: 21809990 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104106 Sun, 31 Jul 2011 23:00:00 +0100 5104106 http://www.medworm.com/index.php?rid=5104105&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809991%26dopt%3DAbstract Conclusions.-Overexpression of Snail, Slug, and dysadherin and activation of Wnt and PI3K/Akt signaling was associated with inactivated E-cadherin in the spindle cells of monophasic fibrous synovial sarcomas, further supporting the hypothesis that this subtype may have developed through neoplastic epithelial-mesenchymal transition. PMID: 21809991 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104105 Sun, 31 Jul 2011 23:00:00 +0100 5104105 http://www.medworm.com/index.php?rid=5104104&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809992%26dopt%3DAbstract Conclusions.-The change in cutoff levels led to a higher concordance between IHC and FISH, but fewer samples were classified as HER2 positive. PMID: 21809992 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104104 Sun, 31 Jul 2011 23:00:00 +0100 5104104 http://www.medworm.com/index.php?rid=5104103&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809993%26dopt%3DAbstract Conclusions.-Classic PRF with the addition of a predominant presence from the undifferentiated component were associated with adverse outcomes in retinoblastoma treated with anterior chemotherapy. The latter may represent chemoresistant clones and more intensive adjuvant chemotherapy may be warranted in these patients. PMID: 21809993 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104103 Sun, 31 Jul 2011 23:00:00 +0100 5104103 http://www.medworm.com/index.php?rid=5104102&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809994%26dopt%3DAbstract Conclusions.-This study suggests that IMP3 may play a role in the carcinogenesis of EAC and has diagnostic utility in differentiating neoplastic and nonneoplastic lesions of the esophagus. PMID: 21809994 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104102 Sun, 31 Jul 2011 23:00:00 +0100 5104102 http://www.medworm.com/index.php?rid=5104101&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809995%26dopt%3DAbstract Conclusions.-IMP3 is a potential independent prognostic biomarker that can be used at the time of initial diagnosis of meningioma to identify patients who have a high risk of developing a recurrence. PMID: 21809995 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104101 Sun, 31 Jul 2011 23:00:00 +0100 5104101 http://www.medworm.com/index.php?rid=5104100&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809996%26dopt%3DAbstract Conclusions.-The thalamic location of 1 tumor represents an undescribed location for this typically superficial cortical tumor. A subset of angiocentric gliomas, similar to other low-grade chronic epilepsy-related tumors of childhood, are associated with coexistent malformation of cortical development, suggesting a developmental basis to their origin. PMID: 21809996 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104100 Sun, 31 Jul 2011 23:00:00 +0100 5104100 http://www.medworm.com/index.php?rid=5104099&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809997%26dopt%3DAbstract Conclusion.-In uveal melanoma, the presence of greater than 5% of cells with monosomy 3, as determined by FISH on isolated nuclei, is associated with the development of metastases within 5 years after enucleation. PMID: 21809997 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104099 Sun, 31 Jul 2011 23:00:00 +0100 5104099 http://www.medworm.com/index.php?rid=5104098&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809998%26dopt%3DAbstract Conclusions.-Twenty-four-hour urine collections for BJP are, in practice, often misleading. At a minimum, one should verify that the 24-hour creatinine excretion is accurate. In addition, it may be possible to use the protein/creatinine ratio from random urine samples to determine 24-hour BJP excretion. PMID: 21809998 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104098 Sun, 31 Jul 2011 23:00:00 +0100 5104098 http://www.medworm.com/index.php?rid=5104097&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21809999%26dopt%3DAbstract Conclusion.-Messenger RNA is well preserved in old archived PreservCyt samples. Triaging women with LSIL, using the Aptima HPV Assay, seems to be effective with a good sensitivity and a good specificity, especially for women 30 years or older. PMID: 21809999 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104097 Sun, 31 Jul 2011 23:00:00 +0100 5104097 http://www.medworm.com/index.php?rid=5104096&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810000%26dopt%3DAbstract We present a case of a 12-month-old infant who developed community-associated methicillin-resistant Staphylococcus aureus bacteremia after an incision and drainage of a skin abscess. He subsequently developed septic emboli to the brain and lungs, and a myocardial cavity in the outlet portion of the interventricular septum. The cavity ruptured 4 days after diagnosis and created a left ventricle to pulmonary artery fistulous communication. The patient died secondary to embolic complications to the brain. We are not aware of any other cases of myocardial abscess rupture in this location of the heart, in a patient of this age, or due to infection with community-associated methicillin-resistant S aureus . PMID: 21810000 [PubMed - in process] (Source: Archives of Pathology and Laboratory Me... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104096 Sun, 31 Jul 2011 23:00:00 +0100 5104096 http://www.medworm.com/index.php?rid=5104095&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810001%26dopt%3DAbstract In this report, to our knowledge we describe the second case of an intramuscular lipoma arising within the pectoralis muscle. Similar to the first published report, our patient's tumor was clinically thought to be a breast mass. However, this example is unique in that it is the first of its kind to be found incidentally during screening ultrasound. Intramuscular lipomas are not routinely included in the radiologic differential diagnosis of a breast mass. However, when the tumor is posteriorly located and appears to involve the pectoralis muscle, the diagnostic possibility of intramuscular lipoma should be entertained. PMID: 21810001 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104095 Sun, 31 Jul 2011 23:00:00 +0100 5104095 http://www.medworm.com/index.php?rid=5104094&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810002%26dopt%3DAbstract Authors: Ashby-Richardson H, Rogers GS, Stadecker MJ Superficial acral fibromyxoma is a rare, slow-growing soft tissue tumor, which is commonly located in the periungual and subungual regions of the fingers and toes in adults. To date, fewer than 50 cases have been reported worldwide. Microscopic examination reveals a moderately circumscribed, nonencapsulated tumor situated in the dermis, which may also extend into the subcutis. The neoplasm consists of a moderately cellular proliferation of stellate and spindle-shaped fibroblast-like cells embedded in a myxocollagenous stroma. Mast cells are easily identified throughout this lesion. Multinucleated stromal cells may also be present, but nuclear atypia and mitotic figures are rare. The tumor shows immunoreactivity for CD34, epithelial m... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104094 Sun, 31 Jul 2011 23:00:00 +0100 5104094 http://www.medworm.com/index.php?rid=5104093&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21810003%26dopt%3DAbstract Authors: Aron M, Zhou M Merkel cell carcinomas are rare cutaneous neoplasms that are known to metastasize to various mucosal sites, including the genitourinary tract. Primary Merkel cell carcinomas of the genitourinary tract are extremely rare and may be mistaken for other more common carcinomas of the genitourinary tract, including urothelial carcinomas and prostatic carcinomas. However, primary Merkel cell carcinoma of the genitourinary tract is a very aggressive tumor with poor prognosis. Accurate diagnosis is crucial for appropriate clinical treatment. The discovery of the Merkel cell polyomavirus as a possible causative agent adds a new dimension in the understanding of the pathogenesis and diagnosis, and possible targeted therapies for this tumor. PMID: 21810003 [PubMed - in ... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5104093 Sun, 31 Jul 2011 23:00:00 +0100 5104093 http://www.medworm.com/index.php?rid=5058133&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732767%26dopt%3DAbstract Authors: Hollis-Perry M PMID: 21732767 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058133 Thu, 30 Jun 2011 23:00:00 +0100 5058133 http://www.medworm.com/index.php?rid=5058132&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732768%26dopt%3DAbstract Authors: Zembowicz A, Prieto VG PMID: 21732768 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058132 Thu, 30 Jun 2011 23:00:00 +0100 5058132 http://www.medworm.com/index.php?rid=5058131&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732769%26dopt%3DAbstract Conclusions.-When reporting melanoma, we recommend that a template be provided, including all the histologic parameters that have been proved significant in determining the tumor staging and prognosis of a patient. The template may also include other details that may be helpful in further analysis of potential complete excisional biopsies or metastatic lesions, such as predominant type of tumor cells, presence or absence of desmoplastic component, or associated benign melanocytic lesions. Although there are several drawbacks in reporting some of these histopathologic parameters (interobserver variability, occasional lack of a perfectly reproducible method for quantifying these criteria), we suggest that at least the essential histopathologic parameters highlighted by the newest version of ... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058131 Thu, 30 Jun 2011 23:00:00 +0100 5058131 http://www.medworm.com/index.php?rid=5058130&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732770%26dopt%3DAbstract Conclusions.-Judicious use of a 4-probe multicolor melanoma FISH procedure can enhance accuracy for diagnosis of melanoma and improve classification of melanocytic proliferations. PMID: 21732770 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058130 Thu, 30 Jun 2011 23:00:00 +0100 5058130 http://www.medworm.com/index.php?rid=5058129&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732771%26dopt%3DAbstract Conclusions.-A better understanding of the earliest stage of melanoma progression, including the contribution of chronic exposure to ultraviolet radiation, may lead to improved classification schemes that direct more effective targeted or personalized therapies for patients. PMID: 21732771 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058129 Thu, 30 Jun 2011 23:00:00 +0100 5058129 http://www.medworm.com/index.php?rid=5058128&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732772%26dopt%3DAbstract Conclusions.-Recognition of the histopathologic pattern of recurrent nevi leads the pathologist to the correct diagnosis in most cases; however, in particularly challenging specimens or in circumstances in which there is insufficient clinical history, immunohistochemical studies have proved helpful in distinguishing recurrent nevi from melanoma. PMID: 21732772 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058128 Thu, 30 Jun 2011 23:00:00 +0100 5058128 http://www.medworm.com/index.php?rid=5058127&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732773%26dopt%3DAbstract Conclusions.-Acral lentiginous melanoma is a clinicopathologic entity with a clear-cut clinical picture: a diameter larger than 0.7 mm; ill-defined, darkly pigmented, flat lesion with irregular borders on acral locations; and the presence of mostly single-cell proliferations of melanocytes along the dermo-epidermal junction. Along with a few additional criteria, these findings should be sufficient to allow the pathologist to make the diagnosis and to recommend complete excision. Fluent communication between clinician and pathologist will facilitate a correct diagnosis. PMID: 21732773 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058127 Thu, 30 Jun 2011 23:00:00 +0100 5058127 http://www.medworm.com/index.php?rid=5058126&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732774%26dopt%3DAbstract Conclusions.-here is no single marker, or combination thereof, that establishes an unequivocal diagnosis of melanoma or nevus. Thus it is necessary to carefully analyze the pattern of expression (patchy versus diffuse) and localization (maturation) in the context of morphologic standard features. PMID: 21732774 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058126 Thu, 30 Jun 2011 23:00:00 +0100 5058126 http://www.medworm.com/index.php?rid=5058125&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732775%26dopt%3DAbstract Conclusion.-New molecular approaches are emerging and are likely to improve the classification of melanocytic neoplasms. PMID: 21732775 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058125 Thu, 30 Jun 2011 23:00:00 +0100 5058125 http://www.medworm.com/index.php?rid=5058124&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732776%26dopt%3DAbstract Conclusions.-Pathologists attempt to comply with requests for materials but usually refuse to release the only diagnostic paraffin block so that materials are retained for possible future needs. Other problems identified in this survey include difficulties in getting blocks returned when needed and poor communication between researchers and laboratories. Lack of reimbursement and inadequate consent are not significant barriers to release of materials. PMID: 21732776 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058124 Thu, 30 Jun 2011 23:00:00 +0100 5058124 http://www.medworm.com/index.php?rid=5058123&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732777%26dopt%3DAbstract Conclusions.-Various reference values provide equivalent laboratory rating. In addition to descriptive feedback, our approach allows calculation of technical test sensitivity and specificity, positive and negative predictive values, agreement rates, and κ values to guide corrective actions. PMID: 21732777 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058123 Thu, 30 Jun 2011 23:00:00 +0100 5058123 http://www.medworm.com/index.php?rid=5058122&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732778%26dopt%3DAbstract Conclusions.-Overexpression of p16 protein in the cytoplasm and decreased expression of p16 protein in the nucleus may play important roles in the evolution of pleomorphic adenoma to Ca-ex-PA. Promoter methylation of the p16 gene may be correlated with the malignant transformation of pleomorphic adenoma. PMID: 21732778 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058122 Thu, 30 Jun 2011 23:00:00 +0100 5058122 http://www.medworm.com/index.php?rid=5058121&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732779%26dopt%3DAbstract Conclusion.-Granular cell tumors of the breast have little long-term risk for recurrence, even when excised with positive margins. Surgical evaluation after nonexcisional biopsy may still be indicated to assess for the possible association of colocalized carcinoma. PMID: 21732779 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058121 Thu, 30 Jun 2011 23:00:00 +0100 5058121 http://www.medworm.com/index.php?rid=5058120&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732780%26dopt%3DAbstract Conclusion.-Aperio's trainable IHC HER2 IA system shows substantial equivalence to MM for Dako's HercepTest and Ventana's PATHWAY HER-2/ neu at 3 clinical sites. Image analysis improved interpathologist agreement in the different clinical sites. PMID: 21732780 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058120 Thu, 30 Jun 2011 23:00:00 +0100 5058120 http://www.medworm.com/index.php?rid=5058119&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732781%26dopt%3DAbstract Conclusions.-The different expression level and pattern of AIF and HtrA2/Omi in SLL/CLL and DLBCL may suggest different apoptotic mechanisms involved in the pathogenesis and prognosis of these diseases. HtrA2/Omi does not appear to be a major player in the regulation of apoptosis of DLBCL and SLL/CLL. PMID: 21732781 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058119 Thu, 30 Jun 2011 23:00:00 +0100 5058119 http://www.medworm.com/index.php?rid=5058118&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732782%26dopt%3DAbstract Conclusion.-Different systems and methods for CD34(+) cell enumeration, properly validated, can support care for patients undergoing transplants and provide meaningful data for multicenter studies or meta-analyses. PMID: 21732782 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058118 Thu, 30 Jun 2011 23:00:00 +0100 5058118 http://www.medworm.com/index.php?rid=5058117&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732783%26dopt%3DAbstract Conclusions.-We believe the routine use of alteplase on clotted blood and bone marrow specimens should become standard for cytogenetics laboratories and may have similar utility in salvaging clotted specimens for other clinical assays requiring intact cells for analysis. PMID: 21732783 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058117 Thu, 30 Jun 2011 23:00:00 +0100 5058117 http://www.medworm.com/index.php?rid=5058116&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732784%26dopt%3DAbstract Conclusions.-Clinical utilization is a potentially rich knowledge base for improving patient care and resident training. Our resident call-tracking system is a useful way for measuring clinical utilization and mining it for actionable information. PMID: 21732784 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058116 Thu, 30 Jun 2011 23:00:00 +0100 5058116 http://www.medworm.com/index.php?rid=5058115&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732785%26dopt%3DAbstract Conclusions.-Mitochondrial disorders are now better recognized with the development of molecular tests for clinical diagnosis. A cooperative effort among primary physicians, diagnostic pathologists, geneticists, and molecular biologists with expertise in mitochondrial disorders is required to reach a definitive diagnosis. PMID: 21732785 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058115 Thu, 30 Jun 2011 23:00:00 +0100 5058115 http://www.medworm.com/index.php?rid=5058114&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732786%26dopt%3DAbstract We present a 67-year-old woman with multiple meningiomas, who developed a high-grade spindle cell tumor 6 months after the resection of a World Health Organization grade I meningioma. It was not clear whether this tumor represented a malignant transformation of meningioma or a primary sarcoma. Malignant transformation of a meningioma is exceptional within this short period and a coexisting sarcoma and meningioma are equally uncommon. Even though these malignant neoplasms are rare in general, they appear to be more prevalent in patients with multiple meningiomas including those with neurofibromatosis type 2. PMID: 21732786 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058114 Thu, 30 Jun 2011 23:00:00 +0100 5058114 http://www.medworm.com/index.php?rid=5058113&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732787%26dopt%3DAbstract Authors: Hillesheim PB, Bahrami S Abstract Prototheca species are an achlorophyllic algae that cause infections primarily in immunocompromised individuals. At least one-half of infectious cases are cutaneous. Because protothecosis is seldom suspected clinically, patients may be subjected to various treatment modalities for extended periods without satisfactory results. Cutaneous protothecosis shares similar clinical and pathologic findings with deep tissue fungal mycoses. The typical presentation occurs most commonly on the face and extremities as erythematous plaques, nodules, or superficial ulcers. Prototheca spp are spherical, unicellular, nonbudding organisms that are sometimes noted on routine hematoxylin-eosin staining but are best visualized with periodic acid-Schiff and Gomori ... Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058113 Thu, 30 Jun 2011 23:00:00 +0100 5058113 http://www.medworm.com/index.php?rid=5058112&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21732788%26dopt%3DAbstract This article provides a brief overview of the clinicopathologic features and possible pathogenesis of this uncommon tumor. PMID: 21732788 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=5058112 Thu, 30 Jun 2011 23:00:00 +0100 5058112 http://www.medworm.com/index.php?rid=4961880&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631256%26dopt%3DAbstract Authors: PMID: 21631256 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=4961880 Tue, 31 May 2011 23:00:00 +0100 4961880 http://www.medworm.com/index.php?rid=4961878&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631257%26dopt%3DAbstract Authors: Musser JM PMID: 21631257 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=4961878 Tue, 31 May 2011 23:00:00 +0100 4961878 http://www.medworm.com/index.php?rid=4961877&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631258%26dopt%3DAbstract Authors: Hernandez JS, Hicks DG PMID: 21631258 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=4961877 Tue, 31 May 2011 23:00:00 +0100 4961877 http://www.medworm.com/index.php?rid=4961859&cid=s_36964_166_f&fid=36964&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21631259%26dopt%3DAbstract Authors: Lehman NL PMID: 21631259 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine) Archives of Pathology and Laboratory Medicine journals http://www.medworm.com/rss/comments.php?id=4961859 Tue, 31 May 2011 23:00:00 +0100 4961859