MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Archivum Immunologiae et Therapiae Experimentalis' source. Wed, 17 Mar 2010 13:39:29 +0100 http://www.medworm.com/index.php?rid=3315404&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F81gm22q665v36628%2F In this study the impact of combined elevation of TNF-α and IL-10 on disease features and outcome of patients with diffuse large B-cell lymphoma (DLBCL) were investigated. Plasma TNF-α and IL-10 levels were determined at the time of diagnosis in a group of 106 DLBCL patients uniformly treated with anthracycline-based regimens. Three risk groups depending on the pretreatment levels of the cytokines were identified: low-, intermediate-, and high-risk groups. In univariate analysis, the cytokine intermediate- and high-risk groups were associated with lower probability of achieving a complete remission (odds ratio [OR] = 0.2, 95% confidence interval [CI] 0.06–0.6, p = 0.006 and OR = 0.05, 95% CI 0.01–0.2, p < 0.0001, respectively) and short... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3315404 Fri, 26 Feb 2010 09:44:08 +0100 3315404 http://www.medworm.com/index.php?rid=3284916&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft25584101187v731%2F The objective of this study was to evaluate the effect of dose and timing of orally delivered alum-adsorbed antigen on the magnitude of the anti-HBs humoral response. Mice were immunized orally by gavage intubation or parenterally by intramuscular injection three times, once every 2 weeks, with doses of 5, 50, or 500 ng alum-adjuvanted HBsAg. A low dose (10 ng) of HBsAg was orally administered three times in different time intervals: 2, 4, 6, and 8 weeks. The three consecutive 5-ng oral doses of the antigen induced immune response at the protective level (≥10 mIU/ml), significantly higher than the reaction elicited by three 50 or 500 ng doses. In contrast, intramuscular delivery of these doses did not differ significantly; however, they induced a five... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3284916 Wed, 17 Feb 2010 18:33:50 +0100 3284916 http://www.medworm.com/index.php?rid=3280851&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4kp11p7657360204%2F Abstract  The interaction of multiple myeloma (MM) cells and bone marrow stromal cells (BMSCs) induces profound changes in the bone marrow environment, influencing osteoclastogenesis and MM cell survival. Differences in receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) production in BMSCs derived from MM patients and control subjects and the apoptosis of BMSCs and MM cells in co-cultures of both cell types were examined. RANKL and OPG expressions were examined by ELISA and semiquantitative RT-PCR. Apoptosis of BMSCs after contact with RPMI8226 and U266 cells was measured by flow cytometry and the level of ALP activity by the spectrophotometric method. OPG production by BMSCs was significantly inhibited after direct contact with RPMI8226 cells. Production... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3280851 Tue, 16 Feb 2010 06:44:46 +0100 3280851 http://www.medworm.com/index.php?rid=3273404&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F86632579171r4225%2F Abstract  T cell epitope-driven vaccine design employs bioinformatic algorithms to identify potential targets of vaccines against infectious diseases or cancer. Potential epitopes can be identified with major histocompatibility complex (MHC)-binding algorithms, and the ability to bind to MHC class I or class II indicates a predominantly CD4+ or CD8+ T cell response. Furthermore, an epitope-based vaccine can circumvent evolutionary events favoring immune escape present in native proteins from pathogens. It can also focus on only the most relevant epitopes (i.e. conserved and promiscuous) recognized by the majority of the target population. Mounting evidence points to the critical role of CD4+ T cells in natural antigen encounter and active immunization. In this paper the need ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3273404 Sun, 14 Feb 2010 06:52:07 +0100 3273404 http://www.medworm.com/index.php?rid=3263680&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F378x400v3l18j230%2F Abstract  A recent study suggested that neuroinflammation plays a major role in the pathogenesis of a number of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Although the precise mechanism is obscure, dysregulation of the signaling transduction pathway in microglia may enhance inflammation, leading to synaptic dysfunction and ultimately to neuronal cell death. The expression and function of the P2X7 receptor (P2X7R), an ATP-gated ion channel abundantly expressed in microglia in the brain, is significantly up-regulated in the postmortem brain of Alzheimer’s disease patients and various neurodegenerative disease animal models. This supports the role of the P2X7R pathway in the progression of neurodegeneration. Blocking P2X7R using brill... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3263680 Tue, 09 Feb 2010 06:47:59 +0100 3263680 http://www.medworm.com/index.php?rid=3255679&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F725574uvq7552u2g%2F Abstract  The concept of gene therapy originated in the mid twentieth century and was perceived as a revolutionary technology with the promise to cure almost any disease of which the molecular basis was understood. Since then, several gene vectors have been developed and the feasibility of gene therapy has been shown in many animal models of human disease. However, clinical efficacy could not be demonstrated until the beginning of the new century in a small-scale clinical trial curing an otherwise fatal immunodeficiency disorder in children. This first success, achieved after retroviral therapy, was later overshadowed by the occurrence of vector-related leukemia in a significant number of the treated children, demonstrating that the future success of gene therapy depends on... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3255679 Mon, 08 Feb 2010 17:20:20 +0100 3255679 http://www.medworm.com/index.php?rid=3255678&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff0n76065x008l304%2F Abstract  Thymic stromal lymphopoietin (TSLP) primes dendritic cells to promote a Th2 inflammatory response. Its action is mediated by a heterodimeric receptor which consists of the interleukin-7 receptor α chain and the TSLP receptor chain (TSLPR). TSLPR resembles the common γ chain subunit utilized by many type 1 cytokine receptors. Normal epithelial cells, keratinocytes, and stromal cells constitutively express TSLP. Dendritic cells that are activated by TSLP promote the development of CD4+ T cells into pro-inflammatory Th2 cells. TSLP thus plays a potentially important role in the pathogenesis of allergic inflammation in asthma and atopic dermatitis. TSLP also has direct effects on other types of cells in the bronchial mucosa. It is over-expressed in the bronchial muco... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3255678 Mon, 08 Feb 2010 17:20:20 +0100 3255678 http://www.medworm.com/index.php?rid=3255680&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr003415043541123%2F Abstract  Developing effective prophylactics to combat tuberculosis is currently in an exploratory stage. The HIV pandemic and emergence of multi- and extensively drug-resistant strains of Mycobacterium tuberculosis indicate that the current preventive measures against this ever-evolving pathogen are inadequate. The currently available vaccine BCG in its present form affords variable protection which usually wanes with aging. Various reasons have been cited to explain the discrepancies in the efficacy of BCG, including generic differences in the different BCG vaccine strains used in immunization program throughout the world. The low efficacy of BCG vaccine has promoted the search for novel vaccines for tuberculosis. The search strategies aim at completely replacing the exist... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3255680 Sat, 06 Feb 2010 18:09:32 +0100 3255680 http://www.medworm.com/index.php?rid=3223898&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq71569u8701t2m63%2F Abstract  The pharmaceutical sector is a part of today’s economy in which the relationship between patents and competition has been receiving increasing attention. The European Commission’s inquiry into this sector adds to the ongoing debate. Its Preliminary Report, published in November 2008, explains and quantifies a number of practices adopted by individual companies operating in the sector. The Report focuses on two strands of interplay between pharmaceutical companies. The first focus is on competition between originator and generic companies and the second relates to competition among originators themselves. The Report’s observations on the former provide us with some important insights into the potential ways of raising barriers to the timely entry of cheaper, ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3223898 Wed, 27 Jan 2010 19:58:53 +0100 3223898 http://www.medworm.com/index.php?rid=3190239&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F13420rw401t1v054%2F Abstract  Percutaneous coronary intervention has become the most common and widely implemented method of heart revascularization. However, the development of restenosis remains the major limitation of this method. Photodynamic therapy (PDT) recently emerged as a new and promising method for the prevention of arterial restenosis. Here the efficacy of chlorin e6 in PDT was investigated in vitro using human vascular smooth muscle cells (TG/HA-VSMCs) as one of the cell types crucial in the development of restenosis. PDT-induced cell death was studied on many levels, including annexin V staining, measurement of the generation reactive oxygen species (ROS) and caspase-3 activity, and assessment of changes in mitochondrial membrane potential and fragmentation of DNA. Photosensitiz... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3190239 Fri, 15 Jan 2010 00:46:50 +0100 3190239 http://www.medworm.com/index.php?rid=3154064&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk448311888515p68%2F Abstract  Once Mycobacterium tuberculosis infects a person it can persist for a long time in a process called latent tuberculosis infection (LTBI). LTBI has traditionally been considered to involve the bacilli remaining in a non-replicating state (dormant) in old lesions but still retaining their ability to induce reactivation and cause active tuberculosis (TB) once a disruption of the immune response takes place. The present review aims to challenge these concepts by including recent experimental data supporting LTBI as a constant endogenous reinfection process as well as the recently introduced concepts of damage-response and tolerance frameworks to explain TB induction. These frameworks highlight the key role of an exaggerated and intolerant host response against M. tuber... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3154064 Mon, 04 Jan 2010 18:01:00 +0100 3154064 http://www.medworm.com/index.php?rid=3154066&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftp04g2x2k082642x%2F Abstract  Elimination of tuberculosis (TB) largely depends upon definitive rapid diagnosis and treatment. Widely used diagnostic tests do not qualify for use in a developing country due to lack of either desired accuracy or their cost. In the present study an enzyme-linked immunosorbent assay was used to evaluate the diagnostic potential of an immuno-dominant 30/32-kDa mycolyl transferase complex (Ag85 complex) and Mycobacterium tuberculosis-specific proteins (ESAT-6 and CFP-10) of the RD1 region. Higher sensitivity (84.1%) with Ag85 complex was observed compared with ESAT-6 (64.9%) and CFP-10 (66%), with almost similar specificity (Ag85: 85.2%, ESAT-6: 88.9%, CFP-10: 85.2%), whereas the individual components of Ag85 complex, i.e. Ag85A, Ag85B, and Ag85C, showed sensitivitie... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3154066 Mon, 04 Jan 2010 18:00:59 +0100 3154066 http://www.medworm.com/index.php?rid=3154065&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb07566715k53517p%2F Abstract  Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is an adaptor molecule containing a Src homology 2 (SH2) domain. SAP is expressed in T cells and natural killer (NK) cells and binds to the cytoplasmic domains of SLAM family receptors, resulting in the subsequent recruitment of Fyn. The SAP (SH2D1A) gene is located on the X chromosome and is responsible for X-linked lymphoproliferative disease, characterized by higher susceptibility to Epstein-Barr virus infection. The SAP-mediated signal is not only essential for the development of NKT cells, i.e. unconventional CD1d-restricted T cells with invariant Vα14 T cell receptors, but also for the regulation of the function of NK cells and conventional T cells. The role of SAP-mediated signaling i... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3154065 Mon, 04 Jan 2010 18:00:59 +0100 3154065 http://www.medworm.com/index.php?rid=3154067&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9205604172075227%2F Abstract  Rheumatoid arthritis is a chronic disorder for which there is no known cure. Concentrating on specific elements of the abnormal immune response that characterizes the disease, scientists are reaching into biotechnology’s bag of tricks to develop immunotherapeutic techniques. This paper will present some advances in the immunotherapy of rheumatoid arthritis targeting inflammatory cytokines and autoreactive T cells. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00005-009-0058-1Authors Guangjie Chen, Shanghai Jiao Tong University School of Medicine Department of Immunology, Institutes of Medical Sciences 280 South Chongqing Road Shanghai 200025 People’s Republic of China Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3154067 Mon, 04 Jan 2010 18:00:53 +0100 3154067 http://www.medworm.com/index.php?rid=3154068&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq741158423638337%2F Abstract  Type 1 iodothyronine deiodinase (D1) is a crucial enzyme which converts the prohormone thyroxine (T4) into active tri-iodothyronine (T3). There has been strong evidence that the metabolism of thyroid hormones is disturbed in some neoplastic tissues such as thyroid, renal, and breast cancer. However, there are few available data about D1 enzyme activity in benign tumors such as hemangioma, which is the most common primary liver tumor. Hence this study aimed to determine the enzymatic activity of D1 in hemangiomas in relation to healthy liver tissue. Seven tumors and healthy control tissues were obtained from patients who had liver resection due to hemangioma. The activity was assessed by measurement of radioactive iodine released by deiodination catalyzed by D1. It... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3154068 Mon, 04 Jan 2010 18:00:52 +0100 3154068 http://www.medworm.com/index.php?rid=3154069&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg1408572j6142605%2F Abstract  The antimicrobial peptide LL-37 is the only known member of the cathelicidin family of peptides expressed in humans. LL-37 is a multifunctional host defense molecule essential for normal immune responses to infection and tissue injury. LL-37 peptide is a potent killer of different microorganisms with the ability to prevent immunostimulatory effects of bacterial wall molecules such as lipopolysaccharide and can therefore protect against lethal endotoxemia. Additional reported activities of LL-37 include chemoattractant function, inhibition of neutrophil apoptosis, and stimulation of angiogenesis, tissue regeneration, and cytokine release (e.g. IL-8). Cellular production of LL-37 is affected by multiple factors, including bacterial products, host cytokines, availabi... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3154069 Mon, 04 Jan 2010 18:00:50 +0100 3154069 http://www.medworm.com/index.php?rid=3154070&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F88pm03667k50h160%2F Abstract  The glomerular basement membrane (GBM) is a kind of net that remains in a state of dynamic equilibrium. Heparan sulfate proteoglycans (HSPGs) are among its most important components. There are much data indicating the significance of these proteoglycans in protecting proteins such as albumins from penetrating to the urine, although some new data indicate that loss of proteoglycans does not always lead to proteinuria. Heparanase is an enzyme which cleaves β 1,4 d-glucuronic bonds in sugar groups of HSPGs. Thus it is supposed that heparanase may have an important role in the pathogenesis of proteinuria. Increased heparanase expression and activity in the course of many glomerular diseases was observed. The most widely documented is the significance of heparanase in ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3154070 Mon, 04 Jan 2010 18:00:49 +0100 3154070 http://www.medworm.com/index.php?rid=2960211&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F85175h65v368385p%2F Conclusions  The three-month therapy with sulfonylurea resulted in a significant increase in CGT in all types of culture tests. This sulfonylurea-related improvement in CGT was associated with a near normalization of GLUT4 expression in the cells. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0052-7Authors Anna Czech, Warsaw Medical University (Brodnowski Hospital) Chair and Department of Internal Medicine, and Diabetology, Second Medical Faculty Warsaw PolandPaweł Piątkiewicz, Warsaw Medical University (Brodnowski Hospital) Chair and Department of Internal Medicine, and Diabetology, Second Medical Faculty Warsaw PolandJan Tatoń, Warsaw Medical University (Brodnowski Hospital) Chair and Department of Internal Medicine, and Diabetology, S... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2960211 Tue, 03 Nov 2009 10:09:38 +0100 2960211 http://www.medworm.com/index.php?rid=2960212&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyu75u73406168780%2F Conclusions  This study documents that both COX isoforms participate in all stages of acute inflammation and that tissue-resident leukocytes, especially macrophages, are important sites of COX-1/COX-2 expression and prostaglandin synthesis. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0053-6Authors Elzbieta Kolaczkowska, Jagiellonian University Department of Evolutionary Immunobiology, Institute of Zoology Kraków PolandAnna Goldys, Jagiellonian University Department of Evolutionary Immunobiology, Institute of Zoology Kraków PolandElzbieta Kozakiewicz, Jagiellonian University Department of Evolutionary Immunobiology, Institute of Zoology Kraków PolandMonika Lelito, Jagiellonian University Department of Evolutionary Immunobiology, Institu... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2960212 Tue, 03 Nov 2009 10:09:28 +0100 2960212 http://www.medworm.com/index.php?rid=2944752&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1p49667h663hq620%2F We present here a summary of the current approaches to validate new diagnostics based on the detection of immunological biomarkers of TB infection. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00005-009-0050-9Authors Giovanni Ferrara, University of Perugia Section of Respiratory Disease, Department of Internal Medicine, St. Maria Hospital Via T. Di Joannuccio 1 05100 Terni ItalyMonica Losi, University of Modena and Reggio Emilia Center for Rare Lung Diseases Modena ItalyLeonardo M. Fabbri, University of Modena and Reggio Emilia Sections of Respiratory Diseases, Department of Oncology and Hematology Modena ItalyGiovanni B. Migliori, WHO Collaborating Centre for TB and Lung Diseases, Fondazione S. Maugeri, Care and Research Institute Tradate ItalyLuca Richeldi, University of... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2944752 Wed, 28 Oct 2009 20:23:24 +0100 2944752 http://www.medworm.com/index.php?rid=2944751&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F94t64ttg60081512%2F Abstract  Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in cancer therapeutic practice for decades. With the increasing population of cancer survivors, there is a growing need to develop preventive strategies and effective therapies against DOX-induced cardiotoxicity, in particular late-onset cardiomyopathy. Although intensive investigations on DOX-induced cardiotoxicity have continued for decades, the underlying mechanisms responsible for DOX-induced cardiotoxicity have not been completely elucidated. A rapidly expanding body of evidence supports the notion that cardiomyocyte death by apoptosis and necrosis is a primary mechanism of DOX-induced ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2944751 Wed, 28 Oct 2009 20:23:24 +0100 2944751 http://www.medworm.com/index.php?rid=2944753&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0571444760865127%2F Abstract  The complement system has long been known to be a major element of innate immunity. Traditionally, it was regarded as the first line of defense against invading pathogens, leading to opsonization and phagocytosis or the direct lysis of microbes. However, from the second half of the twentieth century on, it became clear that complement is also intimately involved in the induction and “fine tuning” of adaptive B- and T-cell responses as well as lineage commitment. This growing recognition of the complement system’s multifunctional role in immunity is consistent with the recent paradigm that complement is also necessary for the successful contraction of an adaptive immune response. This review aims at giving a condensed overview of complement’s rise from a si... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2944753 Wed, 28 Oct 2009 20:23:22 +0100 2944753 http://www.medworm.com/index.php?rid=2944754&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp16120wq2rq3342u%2F Conclusions  Taken as a whole, such accelerated differentiation of CD40-activated B cells suggests that IVIg may participate in re-equilibration of the antibody repertoire by replacing pathological antibodies by de novo harmless antibodies. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0048-3Authors Sonia Néron, Recherche et développement, Héma-Québec, Ingénierie cellulaire 1070, avenue des Sciences-de-la-vie Québec Qc G1V 5C3 CanadaGilles Boire, Université de Sherbrookeet Centre hospitalier universitaire de Sherbrooke Service de rhumatologie, Faculté de médecine et des sciences de la santé Sherbrooke Québec CanadaNathalie Dussault, Recherche et développement, Héma-Québec, Ingénierie cellulaire 1070, avenue des Sciences-de-la... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2944754 Wed, 28 Oct 2009 20:23:21 +0100 2944754 http://www.medworm.com/index.php?rid=2944755&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff054830382508136%2F Abstract  Breast cancer (BrCa) is the second leading cause of cancer-related deaths for women worldwide. Evidence from both patients and mouse cancer models suggests that the simultaneous induction of BrCa-specific CD4+ T cells, CD8+ cytotoxic T cells, and antibodies is crucial for providing immune resistance. However, almost all current vaccines address only a single arm of the immune system, which may explain their lack of efficacy. We believe that the correct response to monovalent vaccines’ “failure” is to increase our knowledge about antitumor protective immunity and to develop a multivalent vaccine molecule that can simultaneously induce multiple arms of the immune system. We highlight here recent advances in anti-BrCa peptide-based vaccine strategies with an emp... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2944755 Wed, 28 Oct 2009 20:23:19 +0100 2944755 http://www.medworm.com/index.php?rid=2877345&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F451x086x4l2w4210%2F Content Type Journal ArticleCategory Varia – ScientometricsDOI 10.1007/s00005-008-0048-8Authors Eugene Garfield, Thomson Scientific ISI Philadelphia PA USA Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X Journal Volume Volume 56 Journal Issue Volume 56, Number 6 / December, 2008 (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2877345 Thu, 08 Oct 2009 10:16:42 +0100 2877345 http://www.medworm.com/index.php?rid=2717238&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff0tvg07q6w557426%2F Abstract  The authors previously showed that interferon regulatory factor (IRF)4 knockout mice are protected from experimental oxazolone and TNBS colitis. Here the effect of IRF4 on the expression of pro- and anti-inflammatory cytokines in TNBS colitis and long-term CD45RBhigh transfer colitis is examined. In TNBS colitis, no differences were found in interleukin (IL)-18 and tumor necrosis factor (TNF)-α expression between IRF4 knockout and wild-type mice. However, significant differences were detected in IL-6 and IL-17 production. Upon treatment with hyper-IL-6, IRF4–/– mice lost their protective properties towards TNBS application. Hyper-IL-6 application induced IL-6 mRNA, but not IL-17 mRNA expression, suggesting that IL-6 deficiency is not primarily responsible for ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2717238 Wed, 19 Aug 2009 18:44:26 +0100 2717238 http://www.medworm.com/index.php?rid=2717237&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp8x3502rq56437x7%2F Conclusion  These findings indicate that eggs from hens immunized with appropriate antigens are a potentially useful source of passive immunity. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0041-xAuthors Marco Cesar Cunegundes Guimarães, UFES Laboratory of Cellular and Molecular Biology of Human Cancer Vitória ES BrazilLívia Gomes Amaral, UFES Laboratory of Cellular and Molecular Biology of Human Cancer Vitória ES BrazilLetícia Batista Azevedo Rangel, UFES Laboratory of Cellular and Molecular Biology of Human Cancer Vitória ES BrazilIan Victor Silva, UFES Laboratory of Cellular and Molecular Biology of Human Cancer Vitória ES BrazilClaudia Gomes Fernandes Matta, UFES Laboratory of Cellular and Molecular Biology of Human Cancer Vitó... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2717237 Wed, 19 Aug 2009 18:44:26 +0100 2717237 http://www.medworm.com/index.php?rid=2731258&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fak871j1ku154n255%2F Abstract  During all human and murine pregnancies, fetal cells enter the maternal circulation and tissues and may persist there for decades. The immune consequences of this phenomenon have been explored for many years as a potential origin of autoimmunity or protection from cancer in women after pregnancy. The leading hypothesis, suggesting that semi-allogenic fetal T cells may trigger a graft-versus-host type of disease, has been supported by several studies showing an increased frequency of fetal-cell microchimerism (FMc) in women affected with systemic sclerosis. However, a large proportion of healthy women or women affected with non-immune disorders also display fetal T cells, challenging the direct pathogenic role of such cells. In addition, recent evidence showing the... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2731258 Tue, 18 Aug 2009 08:25:36 +0100 2731258 http://www.medworm.com/index.php?rid=2717239&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2238uvt723p41388%2F Conclusion  Regardless of the complement resistance of the P. mirabilis strains, the S1959, R110, and R45 LPSs fragmented C3 and induced C3c neo-antigen exposure. The use of complement-deficient human serum allows the conclusion that the Re-type P. mirabilis R45 LPS fragmented C3 by the antibody-independent classical pathway. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0043-8Authors Wiesław Kaca, Huddinge University Hospital, Karolinska Institute Division of Clinical Bacteriology Huddinge SwedenMichał Arabski, Jan Kochanowski University Department of Microbiology, Institute of Biology Świętokrzyska 15 25-406 Kielce PolandRafał Fudała, Jan Kochanowski University Department of Microbiology, Institute of Biology Świętokrzyska 15 25-4... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2717239 Tue, 18 Aug 2009 08:25:35 +0100 2717239 http://www.medworm.com/index.php?rid=2713622&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr7617015m0p67063%2F Abstract  Tuberculosis (TB) is a chronic infectious disease which essentially affects the lungs and produces profound abnormalities on the immune system. Although most people infected by the tubercle bacillus (90%) do not develop the disease during their lifetime, when there are alterations in the immune system, such as co-infection with HIV, malnutrition, or diabetes, the risk of developing active disease increases considerably. Interestingly, during the course of active disease, even in the absence of immunosuppressive conditions, there is a profound and prolonged suppression of Mycobacterium tuberculosis-specific protective immune responses. Several immune factors can contribute to downregulate the protective immunity, permitting disease progression. In general, many of t... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2713622 Tue, 18 Aug 2009 08:25:35 +0100 2713622 http://www.medworm.com/index.php?rid=2713623&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl43rw83553323287%2F Abstract  The skin protects us from water loss and mechanical damage. The surface-exposed epidermis, a self-renewing stratified squamous epithelium composed of several layers of keratinocytes, is most important in the barrier defense against these challenges. Endogenous and exogenous proteases such as kallikreins, matriptase, caspases, cathepsins, and proteases derived from microorganisms are important in the desquamation process of the stratum corneum and are able to activate and inactivate defense molecules in human epidermis. Protease inhibitors such as like LEKTI, elafin, SLPI, SERPINs, and cystatins regulate their proteolytic activity and contribute to the integrity and protective barrier function of the skin. Changes in the proteolytic balance of the skin can result i... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2713623 Mon, 17 Aug 2009 19:00:35 +0100 2713623 http://www.medworm.com/index.php?rid=2713624&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc9h447l2533t8735%2F Abstract  Bronchial asthma is a common immune-mediated disorder characterized by reversible airway inflammation, mucus production, and variable airflow obstruction with airway hyperresponsiveness. Allergen exposure results in the activation of numerous cells of the immune system, of which dendritic cells (DCs) and Th2 lymphocytes are of paramount importance. Although the epithelium was initially considered to function solely as a physical barrier, it is now evident that it plays a central role in the Th2-cell sensitization process due to its ability to activate DCs. Cytokines are inevitable factors in driving immune responses. To the list of numerous cytokines already known to be involved in the regulation of allergic reactions, new cytokines were added, such as TSLP, IL-25... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2713624 Mon, 17 Aug 2009 19:00:34 +0100 2713624 http://www.medworm.com/index.php?rid=2713625&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu443hm5973672510%2F Abstract  Numerous studies have demonstrated that targeting immunogens to Fcγ receptors (FcγR) on antigen (Ag)-presenting cells (APC) can enhance humoral and cellular immunity in vitro and in vivo. FcγR are classified based on their molecular weight, IgG-Fc binding affinities, IgG subclass binding specificity, and cellular distribution and they consist of activating and inhibitory receptors. However, despite the potential advantages of targeting Ag to FcR at mucosal sites, very little is known regarding the role of FcR in mucosal immunity or the efficacy of FcR-targeted mucosal vaccines. In addition, recent work has suggested that FcRn is present in the lungs of adult mice and humans and can transport FcRn-targeted Ag to FcγR-bearing APC within mucosal lymphoid tissue. I... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2713625 Mon, 17 Aug 2009 19:00:31 +0100 2713625 http://www.medworm.com/index.php?rid=2592285&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl3385l1v0568286l%2F Abstract  Drugs targeting memory lymphocytes may allow for a better control of rejection in transplantation, particularly in immunized patients. In this article the rationale of targeting interleukin 7 receptor a (IL-7Rα), a molecule expressed by both memory and naive T cells, is reviewed in the context of transplantation. Whereas naive T cells are partly responsible for acute rejection and are targeted by current immunosuppressive drugs that block costimulatory signals (cyclosporine A, anti-CD3 antibody, anti-CD52 antibody, anti-thymocyte globulin, etc.), memory T cells are resistant to costimulation blockade. As such, memory cells are an obstacle to experimental tolerance induction and may be involved in chronic rejection. There is thus much scientific interest in develo... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2592285 Thu, 09 Jul 2009 12:24:37 +0100 2592285 http://www.medworm.com/index.php?rid=2589293&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Frh73312007642x11%2F Conclusion  The weak MT expression and lack of p53 protein expression in pancreatic SCAs confirms the lack of local invasive potential of the neoplastic lesion. Increased expressions of MT and p53 were observed in the less differentiated tumors. Thus the expression of MT may be a potential prognostic marker for tumors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0033-xAuthors Mariola Śliwińska-Mossoń, Wrocław Medical University Department of Biomedical and Environmental Analyses Grunwaldzka 2 50-355 Wrocław PolandHalina Milnerowicz, Wrocław Medical University Department of Biomedical and Environmental Analyses Grunwaldzka 2 50-355 Wrocław PolandJerzy Rabczyński, Wrocław Medical University Department of Pathological Anatomy Wroc�... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2589293 Mon, 06 Jul 2009 20:24:11 +0100 2589293 http://www.medworm.com/index.php?rid=2589292&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr0506m144g623326%2F Conclusions  Comparing the results of the serological studies with the known chemical structures of the core regions of the LPSs used enabled the identification of a few core oligosaccharide fragments probably involved in the observed cross-reactions. All were located in the most distal part of LPS core region, which made them more easily recognized by specific antibodies. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0034-9Authors Agata Palusiak, University of Łódź Department of General Microbiology, Institute of Microbiology, Biotechnology and Immunology Banacha 12/16 90-237 Łódź PolandZygmunt Sidorczyk, University of Łódź Department of General Microbiology, Institute of Microbiology, Biotechnology and Immunology Banacha 12/16 9... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2589292 Mon, 06 Jul 2009 20:24:11 +0100 2589292 http://www.medworm.com/index.php?rid=2589294&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1202405431827068%2F Conclusions  Thus our results demonstrate that both IBD and CRC are linked with an intensified production of a wide array of monocyte/macrophage pro-inflammatory cytokines which is not accompanied by elevated levels of circulating IL-10, except for its insufficiently inhibitory elevation in UC patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0031-zAuthors Andrzej Szkaradkiewicz, University of Medical Sciences Department of Medical Microbiology Wieniawskiego 3 61-712 Poznań PolandRyszard Marciniak, University of Medical Sciences Department of General, Gastroenterological, and Endocrinological Surgery Poznań PolandIzabela Chudzicka-Strugała, University of Medical Sciences Department of Medical Microbiology Wieniawskiego 3 61-712 Po... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2589294 Mon, 06 Jul 2009 20:24:08 +0100 2589294 http://www.medworm.com/index.php?rid=2589295&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F873858570u631j03%2F Abstract  Statins are inhibitors of the enzyme 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) and they are the most effective agents for lowering cholesterol in clinical practice for the treatment of cardiovascular diseases. However, it has become clear that statins also have pleiotropic immunomodulatory effects in addition to their lipid-lowering properties. As a result, much attention has been focused on their potential as therapeutic agents for the treatment of inflammatory autoimmune diseases. In this review the effect of statins on the expression and function of a variety of immune-relevant molecules will be discussed alongside the underlying mechanisms that contribute to the immunomodulatory effects of statins. Content Type Journal ArticleCategory ReviewDOI 10.1007/... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2589295 Mon, 06 Jul 2009 20:24:07 +0100 2589295 http://www.medworm.com/index.php?rid=2589296&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0389405303487872%2F Abstract  Understanding the adaptive immune response is an area of research critically important in medicine. Several positive regulators of B- and T-cell activation exist to eliminate pathogens, in which CD40 ligand (CD154) plays a fundamental role. It is well documented that CD154 expressed by CD4 T helper cells can be critical in the proper activation of dendritic cells for the productive stimulation of CD8 T cells and is required for proper T-dependent B-cell immunity. However, platelets are an abundant and systemic source of CD154. While classically known to be important for hemostasis and inflammation, several lines of evidence suggest that platelet-derived ligands can modulate the adaptive immune compartment. Content Type Journal ArticleCategory ReviewDOI 10.1007/s... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2589296 Mon, 06 Jul 2009 20:24:04 +0100 2589296 http://www.medworm.com/index.php?rid=2589297&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy35x7162732171t3%2F Abstract  The mobilization of hematopoietic stem/progenitor cells (HSPCs) from bone marrow into peripheral blood (PB) is still not fully understood. Different chemokines, cytokines, growth factors, and neurotransmitters have been described that facilitate this process. However, mounting evidence suggests that mobilization of HSPCs is a part of the immune response and is mediated by innate immunity. We discuss evidence showing that complement system cleavage fragments play a crucial role in both the retention and mobilization of HSPCs by modulating their responsiveness to stromal-derived growth factor-1 (SDF-1) gradient (by C3-derived anaphylatoxins) and by modulating the release of granulocytes into PB that subsequently facilitate the egress of HSPCs (by C5-derived anaphyla... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2589297 Mon, 06 Jul 2009 20:24:03 +0100 2589297 http://www.medworm.com/index.php?rid=2589298&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw57076g2w1651055%2F Abstract  The Legionellae are Gram-negative bacteria able to survive and replicate in a wide range of protozoan hosts in natural environments, but they also occur in man-made aquatic systems, which are the major source of infection. After transmission to humans via aerosols, Legionella spp. can cause pneumonia (Legionnaires’ disease) or influenza-like respiratory infections (Pontiac fever). In children, Legionnaires’ disease is uncommon and is mainly diagnosed in children with immunosuppression. The clinical picture of Legionella pneumonia does not allow differentiation from pneumonia caused by others pathogens. The key to diagnosis is performing appropriate microbiological testing. The clinical presentation and the natural course of Legionnaires’ disease in children ar... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2589298 Mon, 06 Jul 2009 20:01:41 +0100 2589298 http://www.medworm.com/index.php?rid=2563785&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F22x515574778m574%2F Abstract  The ocular microenvironment is both immunosuppressive and anti-inflammatory in nature. Pigment epithelial (PE) cells isolated from the eye possess the ability to suppress the T cell receptor-dependent activation of T cells and the induction of regulatory T cells in vitro. This property is dependent on the cells’ capacity to produce cell-surface and soluble inhibitory molecules, for example CD86 (B7-2), transforming growth factor (TGF)-β, thrombospondin-1, programmed cell death 1 ligand 1 (PD-L1/B7-H1), and cytotoxic T lymphocyte-associated antigen 2α. Cultured ocular PE cells from the iris, ciliary body, and retina can individually suppress T-cell activation via mechanisms that partially overlap. Moreover, PE-derived regulatory T cells acquire functions that pl... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2563785 Wed, 01 Jul 2009 06:18:43 +0100 2563785 http://www.medworm.com/index.php?rid=2474591&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F96t25206370p0304%2F Conclusions  Diabetes, an autoimmune disease, is a serious complication of pregnancy. Therefore, determination of MBL status might be beneficial in identifying type 1 diabetic patients who are at increased risk of developing both vascular complications and poor pregnancy outcomes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0029-6Authors Magdalena Pertyńska−Marczewska, Research Institute Polish Mother’s Memorial Hospital Department of Fetal-Maternal Medicine and Gynecology Łódź PolandMaciej Cedzyński, Polish Academy of Sciences Laboratory of Immunobiology of Infections, Institute of Medical Biology Łódź PolandAnna Świerzko, Polish Academy of Sciences Laboratory of Immunobiology of Infections, Institute of Medical Biology Ł�... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2474591 Thu, 11 Jun 2009 14:11:10 +0100 2474591 http://www.medworm.com/index.php?rid=2458692&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9r667l0210802708%2F Content Type Journal ArticleCategory VariaDOI 10.1007/s00005-009-0028-7Authors Angelo Azzi, JM USDA-HNRCA at Tufts University Vascular Biology Laboratory Office 622, 711 Washington St. Boston MA 02111 USA Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2458692 Thu, 04 Jun 2009 11:19:44 +0100 2458692 http://www.medworm.com/index.php?rid=2448247&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd10v040t05133381%2F Conclusions:  We showed that CD4+CD8−CD3− cells can be derived from highly purified CD34+ cells on TSCs during T-cell lymphopoiesis in vitro. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0022-0Authors Jian Gang Jin, Bei Tai Ping Lu Hospital Hematopoietic Stem Cell Transplant Center Bei Jing P.R.China 100039Bao Jun Bai, Bei Tai Ping Lu Hospital Hematopoietic Stem Cell Transplant Center Bei Jing P.R.China 100039Zhi Juan Yao, Bei Tai Ping Lu Hospital Hematopoietic Stem Cell Transplant Center Bei Jing P.R.China 100039Ren Na Wu, Bei Tai Ping Lu Hospital Hematopoietic Stem Cell Transplant Center Bei Jing P.R.China 100039Kai Feng, Bei Tai Ping Lu Hospital Hematopoietic Stem Cell Transplant Center Bei Jing P.R.China 100039Jiang Wei Hu, Bei Tai ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2448247 Fri, 29 May 2009 06:53:58 +0100 2448247 http://www.medworm.com/index.php?rid=2448251&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk845p66450623308%2F This article takes issue with those who defend a brand of clinical research ethics that tends to substitute the ethics of clinical care of patients being recruited as trial subjects. The distinction between therapeutic and non-therapeutic studies is being disregarded by arguing that research is concerned with the pursuit of knowledge rather than with the medical benefits for patients. Non-competent patients may therefore be recruited for studies that will offer them no medical benefits in spite of involving them in the inherent risks of any biomedical trial. Supported by the World Medical Association, clinicians tend to shun the use of placebos in randomized trials, because of the therapeutic void created in the control group. Nevertheless, investigators continue to consider that sci... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2448251 Fri, 29 May 2009 06:53:57 +0100 2448251 http://www.medworm.com/index.php?rid=2448250&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk28641m02p000460%2F Conclusion:  The acceleration of the apoptosis of PMNs of oral cavity cancer patients before treatment is dependent on both the intrinsic and extrinsic pathways. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00005-009-0023-zAuthors Ewa Jabłońska, Medical University of Białystok Department of Immunology Waszyngtona 15 A 15-274 Białystok PolandMarzena Garley, Medical University of Białystok Department of Immunology Waszyngtona 15 A 15-274 Białystok PolandJakub Jabłoński, Medical University of Białystok Department of Toxicology Białystok Poland Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2448250 Fri, 29 May 2009 06:53:57 +0100 2448250 http://www.medworm.com/index.php?rid=2448249&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcx3625001n2xu637%2F Conclusion:  Increased oxidative stress may lead to premature oxidative DNA damage in the gingival tissue of periodontitis patients and the salivary 8-OHdG level may signify premature oxidative mtDNA damage in diseased gingival tissue. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0026-9Authors Cenk Fatih Çanakçi, Ataturk University Department of Periodontology, Faculty of Dentistry Erzurum TurkeyVarol Çanakçi, Ataturk University Department of Periodontology, Faculty of Dentistry Erzurum TurkeyAbdulgani Tatar, Ataturk University Department of Genetics, Faculty of Medicine Erzurum TurkeyAbubekir Eltas, Ataturk University Department of Periodontology, Faculty of Dentistry Erzurum TurkeyUfuk Sezer, Karadeniz Technical University Department... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2448249 Fri, 29 May 2009 06:53:57 +0100 2448249 http://www.medworm.com/index.php?rid=2448252&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb321667t5r728465%2F Abstract  The human immune system is a myriad of diverse cellular populations, each contributing to maintaining an effective and optimal immune response against infectious agents. It is important to maintain a “self-check” in the immune system so that responses do not go haywire, leading to the development of autoimmune diseases. Regulatory/suppressor T (Treg) cells are a specialized subpopulation of T cells that suppress the activation, expansion, and function of other T cells, thereby maintaining homeostasis through a fine balance between reactivity to foreign and self antigens. Tregs are characterized by surface expression of interleukin (IL)-2 receptor α chain (CD25) and intracellular expression of forkhead box protein P3 (FoxP3). There are at least two important f... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2448252 Fri, 29 May 2009 06:53:56 +0100 2448252 http://www.medworm.com/index.php?rid=2448253&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj81355l516330458%2F Abstract  Because of their unique role in linking the innate and adaptive immune systems, dendritic cells (DCs) have been a logical focus for novel immunotherapies. However, strategies employing active immunization with ex vivo generated and antigen–pulsed DCs have shown limited efficacy in clinical trials. These past approaches did not take into account the complex interactions between cells of the innate immune system and DCs during DC maturation, antigen processing, and presentation to naïve T cells. By better understanding the natural sequence of events occurring in vivo during an effective immune response, we can tailor antitumor immunotherapeutic strategies to augment aspects of this response from the activation of innate immune cells to antigen uptake and DC maturat... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2448253 Fri, 29 May 2009 06:53:55 +0100 2448253 http://www.medworm.com/index.php?rid=2448254&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa68wg0m662112817%2F Abstract  Interleukin (IL)-1 consists of two distinct ligands, IL-1α and IL-1β, with indistinguishable biological activities that signal through the IL-1 type I receptor (IL-1RI). A naturally occurring IL-1 receptor antagonist (IL-1Ra) binds to IL-1RI without initiating signal transduction and prevents IL-1 signaling, competitively inhibiting IL-1-mediated responses. Emerging evidence suggests that the balance between IL-1 agonists and antagonists plays an essential role in a variety of cardiovascular conditions. IL-1 may play a role in atherothrombotic disease by promoting the formation of atheromatous lesions, enhancing vascular inflammation, and triggering plaque destabilization. Following myocardial infarction, IL-1 critically regulates the inflammatory response and i... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2448254 Fri, 29 May 2009 06:53:54 +0100 2448254 http://www.medworm.com/index.php?rid=2448255&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F95r782123410v063%2F Abstract  Ubiquitin ligases are central components of the ubiquitin-proteasome system (UPS), the major machinery for regulated proteolysis in eukaryotic cells. Proteins essential for regulating development, differentiation, proliferation, cell cycling, apoptosis, gene transcription, and signal transduction undergo posttranslational processing via selection by ubiquitin ligases and subsequent controlled proteolysis by the 26S proteasome, the proteolytic unit of the UPS. Neural stem cells (NSCs) are self-renewing multipotent cells of the embryonic and adult mammalian central nervous system. In the last few years, NSCs have generated considerable interest because of their potential to repair neurological damage in preclinical models of stroke, spinal cord injury, and neurodege... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2448255 Fri, 29 May 2009 06:53:53 +0100 2448255 http://www.medworm.com/index.php?rid=2303778&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh5252tu8864588r1%2F Conclusions  This study demonstrated the absence of a systemic TNF-α-mediated inflammatory response at the onset of subarachnoid hemorrhage. Early measurement of serum sICAM-1 levels offers a potential prognostic value in the assessment of patients’ outcome after brain aneurismal rupture. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0010-4Authors Anna Maria Witkowska, Medical University Department of Food Commodities Science and Technology Mieszka I4b 15-054 Białystok PolandMaria Halina Borawska, Medical University Department of Bromatology Białystok PolandKatarzyna Socha, Medical University Department of Bromatology Białystok PolandJan Kochanowicz, Medical University Department of Neurosurgery Białystok PolandZenon Mariak, Medical... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2303778 Thu, 02 Apr 2009 05:59:08 +0100 2303778 http://www.medworm.com/index.php?rid=2303780&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Frw202q8784335516%2F Abstract  After more than two decades of investigation, the biological role of the γδ T-cell receptors (TCRs) remains elusive. In fact, a theory of ligand recognition is still lacking that accounts for their adaptable structure, their peripheral selection, and the observed responses of γδ T cells, which do not require immunization but only include cells sharing germline-encoded components of the TCR. Assuming that all γδ T cells recognize ligands by a common mechanism, we now propose that germline-encoded components of the γδ TCRs provide for the specific recognition of a select set of antigenic determinants (Ags) which appear on the cell surface in various molecular associations. Furthermore, we hypothesize that the adaptivity of the γδ TCRs serves to increase af... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2303780 Tue, 31 Mar 2009 05:53:26 +0100 2303780 http://www.medworm.com/index.php?rid=2303781&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F18g25gj22hk43u72%2F Content Type Journal ArticleCategory VariaDOI 10.1007/s00005-009-0016-yAuthors Xavier Bosch, University of Barcelona Department of Internal Medicine, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Villarroel 170 08036 Barcelona Spain Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2303781 Tue, 31 Mar 2009 05:53:24 +0100 2303781 http://www.medworm.com/index.php?rid=2303784&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy6vp7837017q4042%2F Abstract  Relative indicators are commonly used to remove biases due to different citation practices in various scientific fields. Here we extend our recent investigation on the viability of the use of relative indicators for comparing article impact in different disciplines. We consider citation distributions for papers published in 14 of the 172 disciplines categorized by the Journal Citation Reports. The distribution of the number of citations received by publications in a certain discipline divided by the average number for the discipline is a universal function. Based on it, we compute the relative number of citations needed to be among the q percent most-cited publications in a discipline. The effect of finite samples is also discussed. The average number of citations... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2303784 Tue, 31 Mar 2009 05:53:23 +0100 2303784 http://www.medworm.com/index.php?rid=2303783&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg0681mg67q0642g2%2F Abstract  The recent discovery that natural killer T (NKT) cell nuclei are totipotent opens a novel avenue for further understanding NKT cell function in normal and diseased states. The progeny of a cloned mouse harboring the in-frame rearranged Vα14-Jα18 T cell receptor in one allele showed a significant increase in NKT cell number compared with wild-type or littermate control mice that possessed a different TCR. Importantly, NKT cells from such progeny produced both interferon-γ and interleukin-4, a hallmark of NKT cells. In these progeny, NKT cell development appeared to be instructively, rather than permissively, determined. Using embryonic stem cells prepared via the somatic cell nuclear transfer of NKT nuclei, relatively mature NKT cells were induced under conditio... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2303783 Tue, 31 Mar 2009 05:53:23 +0100 2303783 http://www.medworm.com/index.php?rid=2303788&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7654357692815586%2F Conclusions  These results therefore suggest that, similar to E. coli, LPS with a full core is also required as the acceptor of ECA for P. mirabilis strains to produce ECA LPS . Since ECA PG is not immunogenic unless combined with some proteins, it is likely that ECA PG -protein complexes formed during the intravenous immunization with the Rc mutant strain R4/O28. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0018-9Authors Katarzyna Anna Duda, University of Silesia Department of Microbiology, Faculty of Biology and Environment Protection Katowice PolandKatarzyna Teresa Duda, University of Silesia Department of Microbiology, Faculty of Biology and Environment Protection Katowice PolandAgnieszka Beczała, University of Silesia Department... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2303788 Tue, 31 Mar 2009 05:53:22 +0100 2303788 http://www.medworm.com/index.php?rid=2303786&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp761206156735j57%2F Abstract  Medical journals hold an exalted position in medicine, but have many shortcomings. This perspective reviews some of the shortcomings of medical journals which are primarily related to inexperience, bias, and commercialism. The issues discussed include the uncertain mission of the traditional medical journal in the modern digital age, the inherent inexperience of voluntary editorial boards, the weaknesses and capricious nature of decisions made by the peer-review process, the uneven value of most journal articles, the bias in what gets submitted and published in journals, the misunderstanding about the criteria for authorship, the misunderstanding of the need for ethical review board approval of studies, the misunderstanding of the need for informed consent for res... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2303786 Tue, 31 Mar 2009 05:53:22 +0100 2303786 http://www.medworm.com/index.php?rid=2303792&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F62n053317k3120t0%2F Abstract  Autoimmunity may evolve in predisposed individuals following an exogenous trigger. Autoimmunity is affected by genetic, immune, hormonal, and environmental factors. Immune mechanisms in heart diseases are complex and often not completely understood. Several cardiac disorders are believed to be mediated by an immune reaction. Both humoral and cellular immunity are associated with the development of myocarditis, dilated cardiomyopathy, heart failure, rheumatic fever, and atherosclerosis. Here the diagnostic criteria and autoimmune aspects of autoimmune-mediated cardiac disorders are reviewed. New diagnostic criteria for “autoimmune dilated cardiomyopathy” were recently suggested by the authors. They presume that establishing a dominant autoimmune etiology in som... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2303792 Tue, 31 Mar 2009 05:53:21 +0100 2303792 http://www.medworm.com/index.php?rid=2303790&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnk0511164487577u%2F Conclusion  The results indicate that α-LA treatment effectively protected the brain tissue against endotoxin-induced oxidative stress. Administration of LA could be a useful adjunct to clinical application in the management of septic shock. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0015-zAuthors Anna Gorąca, Medical University of Łódź Chair of Experimental and Clinical Physiology, Department of Cardiovascular Physiology Mazowiecka 6/8 92-215 Łódź PolandKatarzyna Asłanowicz-Antkowiak, Medical University of Łódź Chair of Experimental and Clinical Physiology, Department of Cardiovascular Physiology Mazowiecka 6/8 92-215 Łódź Poland Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print IS... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2303790 Tue, 31 Mar 2009 05:53:21 +0100 2303790 http://www.medworm.com/index.php?rid=2303794&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm08741w655766770%2F Abstract  The enormous repertoire of the vertebrate specific immune system relies on the rearrangement of discrete gene segments into intact antigen receptor genes during the early stages of B-and T-cell development. This V(D)J recombination is initiated by a lymphoid-specific recombinase comprising the RAG1 and RAG2 proteins, which introduces double-strand breaks in the DNA adjacent to the coding segments. Much of the biochemical research into V(D)J recombination has focused on truncated or “core” fragments of RAG1 and RAG2, which lack approximately one third of the amino acids from each. However, genetic analyses of SCID and Omenn syndrome patients indicate that residues outside the cores are essential to normal immune development. This is in agreement with the striki... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2303794 Tue, 31 Mar 2009 05:53:20 +0100 2303794 http://www.medworm.com/index.php?rid=3093348&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp4987445w7w170k6%2F Abstract  The cure rates of Helicobacter pylori infection by using a combination of a proton pump inhibitor (PPI) and antimicrobial agents are mainly influenced by bacterial susceptibility to antimicrobial agents and the magnitude of acid inhibition during the treatment. Currently used empirical triple therapies do not reliably produce a ≥80% cure rate on an intention-to-treat basis. Therefore, tailored regimens based on relevant microbiological findings and pharmacogenomics are recommended for attaining an acceptable ≥95% cure rate. Recently, virulence factors of H. pylori, such as cagA and vacA, are reported to be major factors determining the cure rates. Individuals infected with strains with cagA-negative and vacA s2 genotypes have significantly increased risk of erad... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=3093348 Sat, 14 Feb 2009 07:52:59 +0100 3093348 http://www.medworm.com/index.php?rid=2190352&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp4987445w7w170k6%2F Abstract  The cure rates of Helicobacter pylori infection by using a combination of a proton pump inhibitor (PPI) and antimicrobial agents are mainly influenced by bacterial susceptibility to antimicrobial agents and the magnitude of acid inhibition during the treatment. Currently used empirical triple therapies do not reliably produce a ≥80% cure rate on an intention-to-treat basis. Therefore, tailored regimens based on relevant microbiological findings and pharmacogenomics are recommended for attaining an acceptable ≥95% cure rate. Recently, virulence factors of H. pylori, such as cagA and vacA, are reported to be major factors determining the cure rates. Individuals infected with strains with cagA-negative and vacA s2 genotypes have significantly increased risk of erad... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2190352 Sat, 14 Feb 2009 07:52:59 +0100 2190352 http://www.medworm.com/index.php?rid=2190353&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F72p2145681t828m3%2F We present an analysis of the data of 600 research teams evaluated in 2007–2008. Content Type Journal ArticleCategory Varia - ScientometricsDOI 10.1007/s00005-009-0004-2Authors Nicole Haeffner-Cavaillon, Département d’Evaluation Scientifique INSERM Paris Cedex 13 FranceClaude Graillot-Gak, Département d’Evaluation Scientifique INSERM Paris Cedex 13 France Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2190353 Sat, 14 Feb 2009 07:52:58 +0100 2190353 http://www.medworm.com/index.php?rid=2190355&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw1w3732557342785%2F Conclusions  This study indicates that FST713 medium allows the generation of limited numbers of more mature DCs, while FST3 medium leads to the production of immature DCs in high numbers. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-009-0005-1Authors Bożenna Mytar, Jagiellonian University Medical College Department of Clinical Immunology, Polish-American Institute of Pediatrics Cracow PolandMałgorzata Stec, Jagiellonian University Medical College Department of Clinical Immunology, Polish-American Institute of Pediatrics Cracow PolandKazimierz Węglarczyk, Jagiellonian University Medical College Department of Clinical Immunology, Polish-American Institute of Pediatrics Cracow PolandMarek Zembala, Jagiellonian University Medical College Depa... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2190355 Sat, 14 Feb 2009 07:52:57 +0100 2190355 http://www.medworm.com/index.php?rid=2190354&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F66561772n6638841%2F This article reviews the nature and use of the journal impact factor and other common bibliometric measures for assessing research in the sciences and social sciences based on data compiled by Thomson Reuters. Journal impact factors are frequently misused to assess the influence of individual papers and authors, but such uses were never intended. Thomson Reuters also employs other measures of journal influence, which are contrasted with the impact factor. Finally, the author comments on the proper use of citation data in general, often as a supplement to peer review. This review may help government policymakers, university administrators, and individual researchers become better acquainted with the potential benefits and limitations of bibliometrics in the evaluation of research. ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2190354 Sat, 14 Feb 2009 07:52:57 +0100 2190354 http://www.medworm.com/index.php?rid=2190357&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvnh4j67317527708%2F Abstract  Citation data accumulated on articles from the top and bottom 25 of impact factor (IF)-ranked international journals are compared using 59 international geoscience journals from 1998 and 378 Polish geological papers from 1989–1994. There is a minor risk of being uncited when results are published in high-IF periodicals as the average non-citation rate is 0.88 over a 10-year period in this not very rapidly developing scientific discipline. Similarly, the established error levels in the prognosis of expected citation success versus failure based on the extreme IF quartiles as an evaluation tool is low (at most 12.5). Thus the application of the rank-normalized journal IF as a proxy of real citation frequency and, accordingly, as a predictive tool in the a priori q... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2190357 Sat, 14 Feb 2009 07:52:56 +0100 2190357 http://www.medworm.com/index.php?rid=2190356&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd2816p116025x938%2F Abstract  This paper presents an overview of research assessment methodologies developed in the field of evaluative bibliometrics, a subfield of quantitative science and technology studies, aimed to construct indicators of research performance from a quantitative statistical analysis of scientific-scholarly documents. Citation analysis is one of its key methodologies. The paper illustrates the potentialities and limitations of the use of bibliometric indicators in research assessment. It discusses the relationship between metrics and peer review; databases used as sources of bibliometric analysis; the pros and cons of indicators often applied, including journal impact factors, Hirsch indices, and normalized indicators of citation impact; and approaches to the bibliometric m... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2190356 Sat, 14 Feb 2009 07:52:56 +0100 2190356 http://www.medworm.com/index.php?rid=2190358&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc6515t65l1640101%2F Abstract  Sjögren’s syndrome (SjS) is chronic autoimmune disease manifested by the loss of saliva and/or tear secretion by salivary and/or lacrimal glands, respectively. The pathogenesis of the disease remains elusive, perhaps due to the multiple triggers of the disease. However, substantial advances have been made in attempting to resolve the complexity of SjS using both animal models and human subjects. The primary objectives of this review are to provide a better understanding of the disease processes with major emphasis on the use of mouse models, how genetic predisposition plays a role in the natural history of the disease, as well as a presentation of new findings pertaining to the role of TH1, TH2, and TH17 cells in the pathogenesis of SjS. Content Type Journal ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2190358 Sat, 14 Feb 2009 07:52:55 +0100 2190358 http://www.medworm.com/index.php?rid=2190359&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4g2x24246l366566%2F Abstract  Research assessment in the UK has evolved over a quarter of a century from a loosely structured, peer-review based process to one with a well understood data portfolio and assessment methodology. After 2008, the assessment process will shift again, to the use of indicators based largely on publication and citation data. These indicators will in part follow the format introduced in 2008, with a profiling of assessment outcomes at national and international levels. However, the shift from peer assessment to a quantitative methodology raises critical issues about which metrics are appropriate and informative and how such metrics should be managed to produce weighting factors for funding formulae. The link between publication metrics and other perceptions of research ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2190359 Sat, 14 Feb 2009 07:52:54 +0100 2190359 http://www.medworm.com/index.php?rid=2064883&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F43p211612034t21p%2F Abstract  Based on personal acquaintances and experience dating back to the early 1950s, the senior author reviews the history of viral therapy of cancer. He points out the difficulties encountered in the treatment of human cancers, as opposed by the highly successful viral therapy of experimentally maintained tumors in laboratory animals, especially that of ascites carcinomas in mice. A detailed account of viral therapy of human tumors with naturally oncolytic viruses follows, emphasizing the first clinical trials with viral oncolysates. The discrepancy between the high success rates, culminating in cures, in the treatment of tumors of laboratory animals, and the moderate results, such as stabilizations of disease, partial responses, very rare complete remissions, and freq... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2064883 Tue, 23 Dec 2008 08:08:07 +0100 2064883 http://www.medworm.com/index.php?rid=2039184&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu801855287747470%2F Abstract  Mast cells are important effector cells in allergic inflammatory reactions. The aggregation of the high-affinity IgE receptor (FcεRI) on the surface of mast cells initiates a complex cascade of signaling events that ultimately leads to the release of various mediators involved in allergic inflammation and anaphylactic reactions. The release of these mediators is tightly controlled by signaling pathways that are propagated through the cell by specific phosphorylation and dephosphorylation events. These events are controlled by protein kinases and protein phosphatases which either positively or negatively regulate the propagation of the signal through the cell. This review summarizes the role of both positive and negative regulators of FcεRI-induced mast cell acti... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2039184 Sun, 14 Dec 2008 10:11:57 +0100 2039184 http://www.medworm.com/index.php?rid=2004504&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5n8330h443271xt1%2F Content Type Journal ArticleCategory Varia – ScientometricsDOI 10.1007/s00005-008-0038-xAuthors Andrzej K. Wróblewski, University of Warsaw Institute of Experimental Physics Hoża 69 00-681 Warsaw Poland Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2004504 Sun, 30 Nov 2008 07:13:49 +0100 2004504 http://www.medworm.com/index.php?rid=2004503&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm7vj27t402042446%2F Abstract  Traditionally, the most commonly used source of bibliometric data is the Thomson ISI Web of Knowledge, in particular the (Social) Science Citation Index and the Journal Citation Reports, which provide the yearly Journal Impact Factors. This database used for the evaluation of researchers is not advantageous in the humanities, mainly because books, conference papers, and non-English journals, which are an important part of scientific activity, are not (well) covered. This paper presents the use of an alternative source of data, Google Scholar, and its benefits in calculating citation metrics in the humanities. Because of its broader range of data sources, the use of Google Scholar generally results in more comprehensive citation coverage in the humanities. This pre... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2004503 Sun, 30 Nov 2008 07:13:49 +0100 2004503 http://www.medworm.com/index.php?rid=2004502&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F61757k77440464l8%2F In this study, institutional profile clusters are used to examine which level of the hierarchical subject classification should preferably be used to build subject-normalized citation indicators. It is shown that a set of properly normalized indicators can serve as a basis of comparative assessment within and even among different clusters, provided that their profiles still overlap and such comparison is thus meaningful. Using the example of 24 European universities, a new version of relational charts is presented for the comparative assessment of citation impact. Content Type Journal ArticleCategory Varia – ScientometricsDOI 10.1007/s00005-008-0040-3Authors Wolfgang Glänzel, Katholieke Universiteit Leuven Steunpunt O&O Indicatoren and Department of MSI Leuven BelgiumAndreas S... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2004502 Sun, 30 Nov 2008 07:13:49 +0100 2004502 http://www.medworm.com/index.php?rid=2004508&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F33153418w678466n%2F Abstract  In large, mostly English-speaking countries, where the “critical mass” of scientists working in different subfields of science is achieved, the peer review system may be sufficient to assess the quality of scientific research. However, in smaller countries, outside the Anglo-American circle, it is important to introduce different systems to identify research of high quality. In Poland, a parametric system for assessing the quality of research has been introduced. It was largely based on the impact factor of scientific journals. While the use of this indicator to assess research quality is highly questionable, the implementation of the system in the Polish reality is even worse. Therefore it is important to change and improve the system currently used by the Mi... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2004508 Sun, 30 Nov 2008 07:13:48 +0100 2004508 http://www.medworm.com/index.php?rid=2004507&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk7122136487628p3%2F Conclusions:  The study showed that TBM thickness, but not collagen III deposition, could be a differentiating marker of asthmatics of different disease duration and treatment. The lack of correlation between BHR and features of mucosal inflammation suggests the complexity of BHR development. Corticosteroids can reduce BHR in asthmatics, but it seems to be less effective in reducing subepithelial fibrosis. The role of epithelial TGF-β1 needs to be further investigated since the possibility that it plays a protective and anti-inflammatory role in asthmatic airways cannot be excluded. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-008-0044-zAuthors Aneta Tomkowicz, Wrocław Medical University Department of Dietetics, Faculty of Public Health B... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2004507 Sun, 30 Nov 2008 07:13:48 +0100 2004507 http://www.medworm.com/index.php?rid=2004506&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F403h87q606q2406v%2F Conclusions:  This would facilitate an earlier detection of the deficiency in children, thereby allowing a more comprehensive follow-up and administration of appropriate therapy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-008-0046-xAuthors Maciej Siedlar, Jagiellonian University Medical College Department of Clinical Immunology, Polish-American Institute of Pediatrics Wielicka 265 30-663 Cracow PolandZbigniew Rudzki, Jagiellonian University Medical College Department of Pathology Cracow PolandMagdalena Strach, Jagiellonian University Medical College Department of Internal Medicine and Geriatrics, University Hospital Cracow PolandElżbieta Trzyna, Jagiellonian University Medical College Department of Transplantology, Polish-American Institute... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2004506 Sun, 30 Nov 2008 07:13:48 +0100 2004506 http://www.medworm.com/index.php?rid=2004505&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl177842082xk8231%2F Conclusions:  The convergence of Ig/TCR patterns in Polish and European patients indicates that the strategy for Ig/TCR target identification based on standard primers and protocols might be directly used for the construction of Polish standards and recommendations for MRD diagnostics. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-008-0045-yAuthors Małgorzata Dawidowska, Polish Academy of Sciences Department of Molecular and Clinical Genetics, Institute of Human Genetics Strzeszyńska 32 60-479 Poznań PolandJustyna Jółkowska, Polish Academy of Sciences Department of Molecular and Clinical Genetics, Institute of Human Genetics Strzeszyńska 32 60-479 Poznań PolandTomasz Szczepański, Silesian Academy of Medicine Department of Pediatric Hem... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2004505 Sun, 30 Nov 2008 07:13:48 +0100 2004505 http://www.medworm.com/index.php?rid=2004509&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj77t27lg442k77r3%2F Abstract  Journal impact factors (IF) are often maligned in editorials found in scientific publications, yet citation data can be used appropriately in journal management. The editors of Laboratory Investigation have found that weekly tracking of citation data for this and other highly ranked pathology journals provides valuable feedback on editorial performance and enables us to predict accurate IFs at least six months in advance. Once the IFs are released, it is useful to quantify the contributions of specific article categories, such as reviews and research articles, to the official IFs. In an ongoing attempt to understand the relationship between article downloads and eventual citations, we also analyze the citation rate of papers that had previously been the most frequ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=2004509 Sun, 30 Nov 2008 07:13:47 +0100 2004509 http://www.medworm.com/index.php?rid=1872728&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm2267u015tlkh3l4%2F Conclusions:  Based on the OPS structure and serological results it was concluded that H. alvei strain PCM 1219 should be classified in the same serogroup as the H. alvei type strain ATCC 13337 and five other strains containing D-glucose 1-phosphate and 2-deoxy-2-[(R)-3-hydroxybutyramido]-D-glucose in their O-antigens. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s00005-008-0034-1Authors Ewa Katzenellenbogen, Polish Academy of Sciences Institute of Immunology and Experimental Therapy Weigla 12 53-114 Wrocław PolandNina A. Kocharova, Russian Academy of Sciences N. D. Zelinsky Institute of Organic Chemistry Moscow Russian FederationAgnieszka Korzeniowska-Kowal, Polish Academy of Sciences Institute of Immunology and Experimental Therapy Weigla 12 53-114... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1872728 Mon, 06 Oct 2008 06:30:51 +0100 1872728 http://www.medworm.com/index.php?rid=1859007&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm2267u015tlkh3l4%2F Conclusions:  Based on the OPS structure and serological results it was concluded that H. alvei strain PCM 1219 should be classified in the same serogroup as the H. alvei type strain ATCC 13337 and five other strains containing D-glucose 1-phosphate and 2-deoxy-2-[(R)-3-hydroxybutyramido]-D-glucose in their O-antigens. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s00005-008-0034-1Authors Ewa Katzenellenbogen, Polish Academy of Sciences Institute of Immunology and Experimental Therapy Weigla 12 53-114 Wrocław PolandNina A. Kocharova, Russian Academy of Sciences N. D. Zelinsky Institute of Organic Chemistry Moscow Russian FederationAgnieszka Korzeniowska-Kowal, Polish Academy of Sciences Institute of Immunology and Experimental Therapy Weigla 12 53-11... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1859007 Mon, 06 Oct 2008 06:30:51 +0100 1859007 http://www.medworm.com/index.php?rid=1855567&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F231151028477144m%2F Abstract  Development of T lymphocytes and their survival in the periphery are dependent on signals emanating from cytokine receptors as well as the T cell antigen receptor (TCR). These two signaling pathways play distinct and complementary roles at various stages of T cell development, maturation, survival, activation and differentiation. During immune response to foreign antigens initiated by TCR signaling, cytokines play a key role in the expansion of activated T cells. Even though the initial activation of T cells occurs via the TCR, this requirement can be overcome under certain circumstances. During lymphopenia, cytokines trigger memory CD8+ T cells to undergo antigen non-specific homeostatic expansion, whereas naïve CD8+ T cells require both cytokines and TCR signali... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1855567 Sun, 05 Oct 2008 08:00:10 +0100 1855567 http://www.medworm.com/index.php?rid=1855566&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj47x428m167m77p4%2F Abstract  Mesenchymal stromal cells (MSCs) show significant immune-suppressive properties both in vitro and in vivo. Based on their immune-stealth properties, allogeneic MSCs are used to treat several diseases, for example the injection of MSCs in infarcted heart tissue or their use in bone-cartilage regeneration. The most spectacular treatment was recently described. MSCs were able to down-regulate the severity of graft-versus-host disease, leading to an impressive 20 to 50% increase in the two-year survival of bone marrow transplantation patients. Here the current literature is reviewed to elucidate the different mechanisms involved in these two clinical treatment modalities of MSCs. Content Type Journal ArticleCategory REVIEWDOI 10.1007/s00005-008-0036-zAuthors Lieke ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1855566 Sun, 05 Oct 2008 08:00:10 +0100 1855566 http://www.medworm.com/index.php?rid=1855565&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3j728gxgj0286337%2F Abstract  The first line of defense against invading bacteria is provided by the innate immune system. Morphine and other opiates can immediately disrupt the body’s first line of defense against harmful external bacteria. Opiate, for example morphine, abuse degrades physical and physiologic barriers, and modulates phagocytic cells (macrophages, neutrophils) and, nonspecific cytotoxic T cells (γδ T), natural killer cells, and dendritic cells, that are functionally important for carrying out a rapid immune reaction to invading pathogens. In vitro studies with innate immune cells from experimental animals and humans and in vivo studies with animal models have shown that opiate abuse impairs innate immunity and is responsible for increased susceptibility to bacterial infecti... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1855565 Sun, 05 Oct 2008 08:00:10 +0100 1855565 http://www.medworm.com/index.php?rid=1855564&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk0v573km4l7l2n45%2F Abstract  The peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. To date, three different PPAR isotypes, namely PPAR-α, -δ, and -γ, have been identified in vertebrates and have distinct patterns of tissue distribution. Like all nuclear receptors, the human PPAR-γ (hPPAR-γ) is characterized by a modular structure composed of an N-terminal A/B domain, a DNA-binding domain with two zinc fingers (C domain), a D domain, and a C-terminal ligand-binding domain (E/F domain). Human PPAR-γ exists in two protein isoforms, hPPAR-γ1 and -γ2, with different lengths of the N-terminal. The hPPAR-γ2 isoform is predominantly expressed in adipose tissue, whereas hPPAR-γ1 is relatively widely expressed. Human PPAR-γ plays a critical... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1855564 Sun, 05 Oct 2008 08:00:10 +0100 1855564 http://www.medworm.com/index.php?rid=1855568&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh74842754k286h35%2F Abstract  The immune response triggered following pathogen recognition, though required to clear the infection, can be detrimental if it is produced in excess or fails to resolve promptly. Excessive inflammation contributes to infectious and noninfectious pathologies in the gut (such as inflammatory bowel disease), lung (such as bronchiolitis), and in a variety of autoimmune conditions. T cells contribute significantly to pathology during inflammation. Global anti-inflammatory strategies can alleviate the consequences of exuberant inflammation by suppressing T cell activity, but may leave the patient vulnerable to opportunistic infection. More specific therapies aim to suppress only those T cells involved in the disease process, and one such approach is to target late costi... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1855568 Sun, 05 Oct 2008 08:00:09 +0100 1855568 http://www.medworm.com/index.php?rid=1733195&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj71384128348175m%2F Conclusions:  The preliminary results indicate that intranasal administration of the signal transduction inhibitor POH is a safe, noninvasive, and low-cost method. There were no toxicity events and the regression of tumor size in some patients is suggestive of antitumor activity. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s00005-008-0027-0Authors Clovis Orlando da Fonseca, Centro de Ciências Médicas Serviço de Neurocirurgia, Hospital Universitário Antônio Pedro, Departamento de Cirurgia Geral e Especializada CEP 24030-210 Niterói RJ BrazilRafael Linden, Universidade Federal do Rio de Janeiro Laboratório de Neurogênese Rio de Janeiro R.J BrazilDébora Futuro, Universidade Federal Fluminense Faculdade de Farmácia Niterói 24030-210 RJ Brazi... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1733195 Sun, 24 Aug 2008 17:02:43 +0100 1733195 http://www.medworm.com/index.php?rid=1733194&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft2675x4775270833%2F Abstract  The Wnt/β-catenin pathway plays a significant role in several aspects of cell biology, including the stimulation of gene expression, growth, and mobility. Wnt proteins activate at least three cascades: Wnt/β-catenin, Wnt/Ca2+, and planar cell polarity. β-Catenin is not only a very important element of many intracellular signaling pathways, including the Wnt pathway, but it also takes part in creating intercellular adhesive junctions. When overexpressed or mutated it functions as an oncogen. The Wnt/β-catenin signaling pathway has been shown to play an important role in controlling the proliferation, survival, and differentiation of hematopoietic cells. Thus any aberrant signaling through this pathway may have a negative influence on hematopoiesis. Indeed, some ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1733194 Sun, 24 Aug 2008 17:02:43 +0100 1733194 http://www.medworm.com/index.php?rid=1733196&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2095204jp6067549%2F Abstract  The etiology of Crohn’s disease (CD) is still poorly understood, but recent advances have highlighted the importance of the innate immune system and the critical relationship between the gut flora and the intestinal mucosa. Several combinations of genetic factors predisposing to CD have been described, with the most significant replicable associations including genes for intracellular receptors of bacterial cell walls (NOD2/CARD15) and for bacterial clearance and antigen processing via autophagy (ATG16L1 and IRGM). One theoretical link between susceptibility genes NOD2/CARD15, ATG16L1, and IRGM is that CD is primarily induced by the presence of a dysfunctional immunological response to persistent infection by intracellular bacterial pathogens such as Mycobacterium... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1733196 Sun, 24 Aug 2008 17:02:41 +0100 1733196 http://www.medworm.com/index.php?rid=1733197&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh4431p5654838h0t%2F Abstract  Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β cells are destroyed. Diabetic patients manage their hyperglycemia by daily insulin injections. However, insulin therapy is by no means a cure. Accordingly, a significant effort has been ongoing to develop immunotherapies that effectively prevent and/or treat T1D in the clinic. This review focuses on antigen- and antibody-based immunotherapies and discusses the respective strengths and weaknesses of these approaches. Content Type Journal ArticleCategory REVIEWDOI 10.1007/s00005-008-0025-2Authors Li Li, University of North Carolina at Chapel Hill Department of Microbiology and Immunology Mary Ellen Jones Bldg., Room 635 Campus Box 7290 Chapel Hill NC 27599-7290 USAZuoan Yi, University... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1733197 Sun, 24 Aug 2008 17:02:40 +0100 1733197 http://www.medworm.com/index.php?rid=1733199&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F087r5870074563uw%2F Conclusions:  These data suggest a possible link between impaired apoptosis of PB/SF lymphocytes and increased recruitment of PB BDCs to SF and other elements of the immune system in JIA, including regulatory CD4+/CD25high cells. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s00005-008-0030-5Authors Elżbieta Smolewska, Medical University of Łódź Department of Pediatric Cardiology, 2nd Chair of Pediatrics and Cardiology Sporna 36/50 91-738 Łódź PolandBarbara Cebula, Medical University of Łódź Department of Hematology Łódź PolandHenryka Brózik, Medical University of Łódź Rheumatological Clinic for Children Łódź PolandJerzy Stańczyk, Medical University of Łódź Department of Pediatric Cardiology, 2nd Chair of Pediatrics and Cardio... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1733199 Sun, 24 Aug 2008 17:02:19 +0100 1733199 http://www.medworm.com/index.php?rid=1733198&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F01w70j3904817633%2F Abstract  The interaction of B-cell malignancies with the host immune system is a dynamic and bilateral process. Certain lymphomas more commonly arise within a background of autoimmunity or chronic infection. Initiation of these tumors is commonly reliant on antigenic stimulation and/or T-cell help. Apart from its tumor-fueling role, the host immune response plays a critical role in cancer immunosurveillance and immunoediting. The concept of immunoediting holds that the immune system sculpts the tumor’s immunogenicity in a dynamic process that involves three essential phases: elimination, equilibrium, and escape. Data obtained by studying gene-targeted animals and human lymphomas that support the critical role of the immune response in the initiation, progression, and imm... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1733198 Sun, 24 Aug 2008 17:02:19 +0100 1733198 http://www.medworm.com/index.php?rid=1660244&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj6524480v8g00884%2F Abstract  A considerable part of the scientific community is, at least to some degree, involved in the “impact factor game”. Editors strive to increase their journals’ impact factor (IF) in order to gain influence in the fields of basic and applied research and scientists seek to profit from the “added value” of publishing in top IF journals. In this article we point out the most common “tricks” of engineering and manipulating the IF undertaken by a portion of professionals of the scientific publishing industry. They attempt to increase the nominator or decrease the denominator of the IF equation by taking advantage of certain design flaws and disadvantages of the IF that permit a degree of artificial and arbitrary inflation. Some of these practices, if not sc... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1660244 Sun, 27 Jul 2008 06:59:07 +0100 1660244 http://www.medworm.com/index.php?rid=1660245&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2334036431lr26w6%2F Conclusions   C. trachomatis prostate inflammation was accompanied by an increase in inflammation markers and a decrease in citric acid concentration. Content Type Journal ArticleCategory ORIGINAL ARTICLEDOI 10.1007/s00005-008-0031-4Authors Boźena Zdrodowska-Stefanow, Medical University Department of Dermatology and Venerology Białystok PolandIwona Ostaszewska-Puchalska, Center for Sexually Transmitted Diseases Research and Diagnostics Św. Rocha 3 15-879 Białystok PolandJerzy Badyda, Outpatient Urology Clinic “Multimedica” Białystok PolandZofia Galewska, Medical University Department of Medical Biochemistry Białystok Poland Journal Archivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X (Source: Archivum Immunologiae... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1660245 Sun, 27 Jul 2008 06:59:06 +0100 1660245 http://www.medworm.com/index.php?rid=1481599&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5524l4q4th1h76n6%2F Conclusions:  There is a high frequency of detectable HHV-6 viral load in stem cell transplant recipients in Poland. Further investigation to monitor HHV-6 reactivation in graft recipients will be important to improve outcome for these patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-008-0021-6Authors Tomasz Dzieciątkowski, Medical University of Warsaw Chair and Department of Medical Microbiology Chałubińskiego 5 02-004 Warsaw PolandMaciej Przybylski, Medical University of Warsaw Chair and Department of Medical Microbiology Chałubińskiego 5 02-004 Warsaw PolandTigran Torosian, Medical University of Warsaw Department of Hematology, Oncology and Internal Medicine Warsaw PolandAgnieszka Tomaszewska, Medical University of Warsaw Departm... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1481599 Fri, 30 May 2008 06:01:49 +0100 1481599 http://www.medworm.com/index.php?rid=1481598&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd5g1297n5m526845%2F Discussion:  Cytokines over-expressed by BMSCs of MM patients can function as growth factors for myeloma cells (IL-6, IL-10, HGF), migration stimulatory factors for tumor plasma cells (TNF-α, HGF), adhesion stimulatory factors (HGF, BAFF and OPN), stimulators of osteoclastogenesis (IL-6, TNF-α), and angiogenic factors (TNF-α). The results of this experiment strongly suggest that the BMSCs from MM patients differed in spontaneous and myeloma cell-induced production of cytokines, especially of HGF and BAFF, and these abnormalities were both primary and acquired by the BMSCs on contact with the MM cells. This in turn suggests the presence of an undefined, autocrine stimulation pathway resulting in a prolonged production of cytokines even in long-term cultures in vitro and i... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1481598 Fri, 30 May 2008 06:01:49 +0100 1481598 http://www.medworm.com/index.php?rid=1481600&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvh61601545017112%2F This article starts from an analysis of the concepts of responsibility and complicity, examining alternative options regarding the responsibility of scientists. Within the context of the basic conflict between the freedom of science and the duty to avoid causing harm, two positions are discussed: moral skepticism and the ethics of responsibility by Hans Jonas. According to these reflections, four duties are suggested and evaluated: stopping research, systematically carrying out research for dual-use applications, informing public authorities, and not publishing results. In the conclusion it is argued that these duties should be considered as imperfect duties in a Kantian sense and that the individual scientist should be discharged as much as possible from obligations which follow fr... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1481600 Fri, 30 May 2008 06:01:47 +0100 1481600 http://www.medworm.com/index.php?rid=1481601&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl7n430t404811871%2F Conclusions:  These data extend the authors’ unique transgenic transplantation model to the investigation of CD8 T cell function. The initial results confirm fundamental functional similarity between the CD4 and CD8 T cell subsets and provide insight into the considerable redundancy underlying T cell mechanisms mediating allograft rejection. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-008-0019-0Authors Paige M. Porrett, Hospital of the University of Pennsylvania Harrison Department of Surgical Research, Department of Surgery Philadelphia PA 19104 USAMajor K. Lee, Hospital of the University of Pennsylvania Harrison Department of Surgical Research, Department of Surgery Philadelphia PA 19104 USAMoh Moh Lian, Hospital of the University of Pen... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1481601 Fri, 30 May 2008 06:01:45 +0100 1481601 http://www.medworm.com/index.php?rid=1481602&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc0536260710j7w47%2F Abstract  Understanding the homeostatic mechanisms governing lymphocyte pools achieves critical importance as lymphocyte-targeted therapies expand in use and scope. The primacy of B lymphocyte stimulator (BLyS) family ligands and receptors in governing B lymphocyte homeostasis has become increasingly clear in recent years, affording insight into novel opportunities and potential pitfalls for targeted B cell therapeutics. Interclonal competition for BLyS-BR3 interactions determines the size of naïve B cell pools and can regulate the stringency of selection applied as cells complete maturation. Thus one of the predicted consequences of ablative therapies targeting primary pools is relaxed negative selection. This suggests that BLyS levels and B cell reconstitution rates may ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1481602 Fri, 30 May 2008 06:01:44 +0100 1481602 http://www.medworm.com/index.php?rid=1481603&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4108173l774u3175%2F Abstract  It is becoming increasingly evident that cancer constitutes a group of diseases involving altered stem-cell maturation/differentiation and the disturbance of regenerative processes. The observed malignant transformation is merely a symptom of normal differentiation processes gone astray rather than the primary event. This review focuses on the role of cancer stem cells (CSCs) in three common but also relatively under-investigated cancers: head and neck, ovarian, and testicular cancer. For didactic purpose, the physiology of stem cells is first introduced using hematopoietic and mesenchymal stem cells as examples. This is followed by a discussion of the (possible) role of CSCs in head and neck, ovarian, and testicular cancer. Aside from basic information about the ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1481603 Fri, 30 May 2008 06:01:43 +0100 1481603 http://www.medworm.com/index.php?rid=1481604&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb88p4l73ln0913v5%2F Abstract  Regulatory T cells (Treg) enriched in FoxP3+, glucocorticoid-induced TNF receptor+, and cytotoxic T-lymphocyte-associated antigen-4+ exert a potential to suppress effector T cells in the periphery. These cells exist in markedly higher proportions within tumor-infiltrating lymphocytes, peripheral blood lymphocytes, and/or regional lymph node lymphocytes of patients with cancer and their frequencies are suggested to be strongly related to tumor progression and inversely correlated with the efficacy of treatment. Tumor-specific Treg cells require ligand-specific activation and cell-to-cell contact to exert their suppressive activity on tumor-specific effector cells (CD8+ cytotoxic T lymphocytes and CD4+ Th cells), which includes decreased cytotoxity, proliferation, and... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1481604 Fri, 30 May 2008 06:01:42 +0100 1481604 http://www.medworm.com/index.php?rid=1339929&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx0h85741x17171p6%2F Abstract  The key of the immune system is to protect the host from foreign threat posed by pathogens and from the internal threat posed by self-attacking lymphocytes. The ability to discriminate self versus non-self ensures that only “non-self” pathogens, but not the self antigens, are attacked. Such tolerance to “self” arises from the central tolerance mechanisms that include the deletion of thymocytes with high reactivity to self antigens and also the induction of unresponsiveness of autoreactive T cells in the periphery. Natural regulatory T cells (nTregs) directly inhibit effector T cells, and keep their proliferation in control. Apart from preventing autoimmune reactions, Tregs also contribute to peripheral immune homeostasis as evidenced by the excessive lymph... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1339929 Sun, 30 Mar 2008 05:56:42 +0100 1339929 http://www.medworm.com/index.php?rid=1339932&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6g17185vq67412w6%2F Abstract  Leishmaniasis causes significant morbidity and mortality worldwide, constituting an important public health problem. Leishmania infections cause a wide spectrum of diseases, ranging in severity from spontaneously healing skin lesions to fatal visceral disease. Attempts to develop an effective vaccine to control leishmaniasis have been shown to be feasible, but no vaccine is in active clinical use. The ability to create genetically modified parasites by eliminating virulence or essential genes is considered a powerful alternative in the development of an effective protective vaccine. Here, recent findings related to genetically defined live attenuated Leishmania parasites as promising vaccine candidates are reviewed. Content Type Journal ArticleCategory Mini-Revie... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1339932 Sun, 30 Mar 2008 05:56:40 +0100 1339932 http://www.medworm.com/index.php?rid=1339931&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fel786h65738h4010%2F Conclusions:  The results of this study provide further evidence that a natural specific cellular immune response against this mucin epitope exists in breast cancer patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-008-0011-8Authors Konrad Kokowski, Charité-Universitätsmedizin Berlin Medical Clinic of Oncology and Hematology Charité Campus Mitte, Charitéplatz 1 10117 Berlin GermanyUlf Harnack, Charité-Universitätsmedizin Berlin Medical Clinic of Oncology and Hematology Charité Campus Mitte, Charitéplatz 1 10117 Berlin GermanyDavid C. Dorn, Charité-Universitätsmedizin Berlin Medical Clinic of Oncology and Hematology Charité Campus Mitte, Charitéplatz 1 10117 Berlin GermanyGabriele Pecher, Charité-Universitätsmedizin Berlin Me... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1339931 Sun, 30 Mar 2008 05:56:40 +0100 1339931 http://www.medworm.com/index.php?rid=1339930&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn175884231161651%2F The objective of this article was to review the literature to be able to offer the readers comprehensive and updated information on the basic etiological and physiopathological mechanisms and to make special emphasis on the current management of urticaria, thus promoting continuous medical education. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00005-008-0013-6Authors Ahmad T. Khalaf, Wuhan University Department of Immunology, Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Related Diseases and Center for Medical Research, Wuhan University School of Medicine Dong Hu Road 115 Wuchang, Wuhan 430071 P. R. ChinaWang Li, Wuhan University Department of Immunology, Laboratory of Allergy and Clinical Immunology, Institute of Allergy and Immune-Relat... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1339930 Sun, 30 Mar 2008 05:56:40 +0100 1339930 http://www.medworm.com/index.php?rid=1339933&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw877720273v13636%2F Conclusions:  A distal, trisaccharide fragment of the P. penneri 8 LPS core region is suggested to determine the cross-reactions of the tested antisera with the six P. penneri LPSs. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-008-0012-7Authors Agata Palusiak, University of Łódź Department of General Microbiology, Institute of Microbiology and Immunology Banacha 12/16 90-237 Łódź PolandMonika Dzieciątkowska, Polish Academy of Sciences Department of Immunochemistry, Institute of Immunology and Experimental Therapy Wrocław PolandZygmunt Sidorczyk, University of Łódź Department of General Microbiology, Institute of Microbiology and Immunology Banacha 12/16 90-237 Łódź Poland Journal Archivum Immunologiae et Therapiae Experimen... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1339933 Sun, 30 Mar 2008 05:56:39 +0100 1339933 http://www.medworm.com/index.php?rid=1339935&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd55845228n767244%2F Abstract  The role of response gene to complement (RGC)-32 as a cell cycle regulator has been attributed to its ability to activate cdc2 kinases and to induce S-phase entry and mitosis. However, recent studies revealed novel functions for RGC-32 in diverse processes such as cellular differentiation, inflammation, and fibrosis. Besides responding to C5b-9 stimulation, RGC-32 expression is also induced by growth factors, hormones, and cytokines. Transforming growth factor β activates RGC-32 through Smad and RhoA signaling, thus initiating smooth muscle cell differentiation. Accumulating evidence has drawn attention to the deregulated expression of RGC-32 in human malignancies, hyper-immunoglobulin E syndrome, and fibrosis. RCG-32 expression is up-regulated in cutaneous T cel... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1339935 Sun, 30 Mar 2008 05:56:38 +0100 1339935 http://www.medworm.com/index.php?rid=1339934&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmg3m57706h46x884%2F Abstract  B lymphocytes are regarded as professional antigen-presenting cells (APCs) despite their primary role in humoral immunity. Over the last two decades, studies designed to define the role of the B cells as APCs have generated discrepant results, showing that B cells are either unnecessary or required for T cell priming and either immunogenic or tolerogenic to T cells. The reasons for these discrepancies are not clear. Here we review mechanisms regulating B cell antigen presentation and the data derived from the major studies conducted by different groups representing each school of thought. In general it is clear that B cells process and present specific and nonspecific antigens differently. The presentation of specific antigen through the B cell antigen receptor oc... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1339934 Sun, 30 Mar 2008 05:56:38 +0100 1339934 http://www.medworm.com/index.php?rid=1339936&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5779w70r683j128q%2F Conclusions:  These results indicate that the anti-inflammatory properties of MNA demonstrated previously in vivo do not depend on its capacity to suppress the functions of immune cells, but more likely may be related to its action on vascular endothelium. The authors suggest that the limited permeability for exogenous MNA, in contrast to that for NA, may be responsible for its lack of suppressor activity against Mϕ. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-008-0009-2Authors Rafał Biedroń, Jagiellonian University College of Medicine Department of Immunology Czysta 18 31-121 Kraków PolandMarta Ciszek, Jagiellonian University College of Medicine Department of Immunology Czysta 18 31-121 Kraków PolandMarianna Tokarczyk, Jagiellonian Uni... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1339936 Sun, 30 Mar 2008 05:56:37 +0100 1339936 http://www.medworm.com/index.php?rid=1215061&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpt5p518786245666%2F Abstract  Neutrophils are essential for host defense and detect the presence of invading microorganisms through recognition of pathogen-associated molecular patterns. Among these receptors are Toll-like receptors (TLRs). Neutrophils express all known TLRs except for TLR3. TLR9, localized intracellularly, is to date the best characterized sensor for bacterial DNA, containing short sequences of unmethylated CpG motifs, though TLR9-independent intracellular DNA recognition mechanism(s) may also exist. Bacterial DNA has profound impact on neutrophil functions; it promotes neutrophil trafficking in vivo, induces chemokine expression, regulates expression of adhesion molecules, enhances phagocyte activity, and rescues neutrophils from constitutive apoptosis. TLR9 stimulation resul... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1215061 Tue, 05 Feb 2008 15:46:59 +0100 1215061 http://www.medworm.com/index.php?rid=1215060&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffg15701k462n8704%2F Abstract  Systemic lupus erythematosus (SLE) is an autoimmune disease that results in immune-mediated damage to multiple organs. Among these, kidney involvement is the most common and fatal. Spontaneous lupus nephritis (SLN) in mouse models has provided valuable insights into the underlying mechanisms of human lupus nephritis. However, SLN in mouse models takes 6–12 months to manifest; hence there is clearly the need for a mouse model that can be used to unveil the pathogenic processes that lead to immune nephritis over a shorter time frame. In this article more than 25 different molecules are reviewed that have been studied both in the anti-glomerular basement membrane (anti-GBM) model and in SLN and it was found that these molecules influence both diseases in a parallel... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1215060 Tue, 05 Feb 2008 15:46:59 +0100 1215060 http://www.medworm.com/index.php?rid=1215059&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy5128k077p326827%2F Abstract  The rapid evolution of experimental data has acknowledged the critical relevance of immune biology in stem cell research. It appears that efficient transfer of stem cells to patients requires robust analyses of the immune properties as well as the responses of the stem cells to immune mediators. This review discusses the biology of adult human mesenchymal stem cells (MSCs) in the context of immunology. MSCs are pluripotent, self-renewing cells with the potential for tissue regeneration, for example the repair of bone, cartilage, tendon, ligament, skeletal muscle, and cardiac muscle. MSCs have also been shown to transdifferentiate into cells of ectodermal origin, such as neurons. MSCs are located in perfused areas of adult bone marrow, whereas hematopoietic stem ce... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1215059 Tue, 05 Feb 2008 15:46:59 +0100 1215059 http://www.medworm.com/index.php?rid=1215056&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0073w8t82340m6x0%2F Conclusions:  These results suggest that the MBL complement activation pathway itself does not contribute to the frequency of angioedema attacks. Infections with H. pylori and HBV may slightly influence the disease score (not significant). Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-008-0004-7Authors Maciej Cedzyński, Polish Academy of Sciences Laboratory of Immunobiology of Infections, Center of Medical Biology Łódź PolandKazimierz Madaliński, Child Health Memorial Institute Department of Clinical Microbiology and Immunology; Allergology Al. Dzieci Polskich 20 04-736 Warsaw PolandHanna Gregorek, Child Health Memorial Institute Department of Clinical Microbiology and Immunology; Allergology Al. Dzieci Polskich 20 04-736 Warsaw PolandAnna... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1215056 Tue, 05 Feb 2008 15:46:59 +0100 1215056 http://www.medworm.com/index.php?rid=1215062&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7068t34211r11102%2F Abstract  Fas (CD95/APO-1) belongs to the tumor necrosis factor receptor family and its signaling pathway has been extensively studied over the past 15 years. Blockade of the Fas-mediated apoptotic signal leads to abusive lymphoproliferation, auto-immunity, and an increased risk of developing lymphoma and leukemia. Fas engagement drives the formation of a complex termed DISC (death-inducing signaling complex), which contains the adaptor molecule Fas-associated protein, two members of the caspase family caspase-8 and −10, and a pseudo-caspase termed c-FLIP. According to different authors, DISC formation relies either on the redistribution of Fas into the lipid rafts or the recruitment of the actin cytoskeleton and receptor endocytosis or the production of ceramide. However... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1215062 Tue, 05 Feb 2008 15:46:58 +0100 1215062 http://www.medworm.com/index.php?rid=1215058&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe30h22272p212836%2F Conclusions:  These findings, despite such limitations as a small sample size, suggest a possible role for WBCT as a short-term adjuvant treatment for mood and anxiety disorders. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-008-0006-5Authors Joanna Rymaszewska, Wrocław Medical University Research Unit of Consultation Psychiatry and Behavioral Medicine, Department of Psychiatry Pasteura 10 50-367 Wrocław PolandDavid Ramsey, Wrocław Medical University Research Unit of Consultation Psychiatry and Behavioral Medicine, Department of Psychiatry Pasteura 10 50-367 Wrocław PolandSylwia Chładzińska-Kiejna, Wrocław Medical University Research Unit of Consultation Psychiatry and Behavioral Medicine, Department of Psychiatry Pasteura 10 50-367 Wroc... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1215058 Tue, 05 Feb 2008 15:46:58 +0100 1215058 http://www.medworm.com/index.php?rid=1215057&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn214074rm262m181%2F Conclusions:  There were some differences in the memory compartment of peripheral blood T cells between asthmatic children and healthy controls. The increase in the number of CD8+ T cells expressing the memory marker (CD45RO) in children with allergic asthma may indicate that CD8+ T cells play a role in the pathogenesis of asthma. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-008-0005-6Authors Edyta Machura, Medical University of Silesia Chair and Department of Pediatric Gastroenterology, Allergology, and Developmental Disorders Zabrze PolandBogdan Mazur, Medical University of Silesia Department of Microbiology and Immunology Jordana 19 41-808 Zabrze PolandWojciech Pieniążek, Medical University of Silesia Chair and Department of Pediatric Gas... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1215057 Tue, 05 Feb 2008 15:46:58 +0100 1215057 http://www.medworm.com/index.php?rid=1215055&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx1x4337tw31l6738%2F Abstract  Zinc is required for multiple cellular tasks, and especially the immune system depends on a sufficient availability of this essential trace element. During the last decades, many studies attempted to affect the outcome of various diseases by zinc supplementation. These efforts either aimed at supporting immunity by zinc administration or at correcting a loss of zinc secondary to the disease to restore the zinc-dependent functions of the immune system. This review aims to summarize the respective findings and to discuss possible molecular mechanisms by which zinc could influence viral, bacterial, and parasitic infections, autoimmune diseases, and the response to vaccination. Zinc supplementation in diseases such as diarrhea, chronic hepatitis C, shigellosis, lepros... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1215055 Tue, 05 Feb 2008 15:46:58 +0100 1215055 http://www.medworm.com/index.php?rid=1074567&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr3722502kq585641%2F Abstract  The CD3ζ chain, a component of the T cell receptor (TCR)/CD3 complex, is considered to be a limiting factor in the assembly and transport of the TCR/CD3 complex to the cell surface and is crucial to receptor signaling function. Recent studies have demonstrated altered expression and function of this signal transduction molecule in T and natural killer cells in patients with chronic inflammatory/autoimmune diseases. In this review, current knowledge concerning the expression of CD3ζ chain as well as the mechanisms responsible for abnormal expression of this molecule in systemic lupus erythematosus, rheumatoid arthritis, and childhood idiopathic nephrotic syndrome are summarized. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00005-007-0042-6Authors L... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1074567 Mon, 03 Dec 2007 18:21:09 +0100 1074567 http://www.medworm.com/index.php?rid=1074565&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa265582k00k41316%2F Abstract  The incidence of cutaneous malignant melanoma, tumors arising from melanocytes, has increased markedly over the past few years in many countries. Although early melanoma is curable through surgical excision, the prognosis of advanced melanoma is very poor, this tumor being resistant to current therapies. Thus there is a need for new therapies to improve the treatment of advanced melanoma. This review provides an overview of recent discoveries in the genetics of melanoma which could offer new therapeutic opportunities. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00005-007-0043-5Authors Amélie Marquette, INSERM Unit 841, IMRB, Equipe 02 Faculté de Médecine de Créteil, Department of Immunology, Dermatology, and Oncology 8 rue du Général Sarrail 9... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1074565 Mon, 03 Dec 2007 18:21:09 +0100 1074565 http://www.medworm.com/index.php?rid=1074562&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F28860g22j2h28400%2F Abstract  Epithelial cells are the first line of defense against invading microbial pathogens. They are important contributors to innate mucosal immunity and generate various and sophisticated anti-microbial defense mechanisms, including the formation of a tight barrier and secretion of anti-microbial substances as well as inflammatory mediators. To provide these active defense mechanisms, epithelial cells functionally express various pattern-recognition receptors. Toll-like receptors have been shown to recognize conserved microbial patterns mediating inducible activation of innate immunity. Mucosal surfaces, however, are prone to contact with pathogenic as well as non-pathogenic microbes and, therefore, immune-recognition principles have to be strictly regulated to avoid u... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1074562 Mon, 03 Dec 2007 18:21:09 +0100 1074562 http://www.medworm.com/index.php?rid=1074566&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhn276141h2050836%2F Abstract  Vaccination is historically one of the most successful strategies for the prevention of infectious diseases. For safety reasons, modern vaccinology tends toward the usage of inactivated or attenuated microorganisms and uses predominantly subunit vaccines. The antigens need to be clearly defined, pure, stable, appropriately composed, and properly presented to the immune system of the host. Differing ratios of various proportions between specific CD4+ and CD8+ T cell responses are essential for conferring the required protection in the case of individual vaccines. To stimulate both CD4+ and CD8+ T cells, the antigens must be processed and presented to both antigen-presentation pathways, MHC I and MHC II. Protein antigens delivered by vaccination are processed as extr... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1074566 Mon, 03 Dec 2007 18:21:08 +0100 1074566 http://www.medworm.com/index.php?rid=1074564&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq3qt65350182023w%2F Conclusions:  The oxidative burst in periodontitis may lead to significant local damage to nucleic acids. The significantly decreased TAS level in the gingival blood of CP patients compared with the healthy subjects suggests the possibility of a significant decrease in local antioxidant system capacity during the course of periodontitis. The decreased TAS level in the peripheral blood in the group of all patients with periodontitis may be one of the pathogenic mechanisms underlying the links between periodontal disease and several systemic diseases for which periodontitis is regarded as a independent risk factor. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-007-0047-1Authors Tomasz Konopka, Wrocław Medical University Department of Oral Pat... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1074564 Mon, 03 Dec 2007 18:21:08 +0100 1074564 http://www.medworm.com/index.php?rid=1074563&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1g77311661631648%2F Conclusions:  The lack of direct chemotactic effects of recombinant human α(1)-proteinase inhibitor despite anti-inflammatory effects in other biological activities of leukocytes may contribute to the preserved antibacterial defense mechanisms observed in patients under experimental augmentation therapy with inhaled α(1)-proteinase inhibitor. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-007-0045-3Authors Birgit Mosheimer, Medical University of Innsbruck Division of General Internal Medicine, Department of Medicine A-6020 Innsbruck AustriaReinhard Alzner, Medical University of Innsbruck Division of General Internal Medicine, Department of Medicine A-6020 Innsbruck AustriaChristian J. Wiedermann, Medical University of Innsbruck Division of Ge... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1074563 Mon, 03 Dec 2007 18:21:08 +0100 1074563 http://www.medworm.com/index.php?rid=1074561&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F98607190800v7362%2F Conclusions:  The kind of culture supplementation had a great impact on the apoptosis of cultured PBMCs. It could also influence the yield of monocyte-derived DCs. It was also confirmed that autologous and allogenic serums provide suitable microenvironments for the generation of autologous DCs from NSCLC patients. The choice of culture supplementation for DC generation is still unsolved and further studies should be undertaken. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-007-0046-2Authors Paweł Krawczyk, Medical University of Lublin Department of Pneumology, Oncology and Allergology Jaczewskiego 8 20-950 Lublin PolandKamila Wojas, Medical University of Lublin Clinical Immunology Department Lublin PolandJanusz Milanowski, Medical University... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=1074561 Mon, 03 Dec 2007 18:21:08 +0100 1074561 http://www.medworm.com/index.php?rid=930372&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe25j870j04w6k7x6%2F Conclusions:  Serum hsCRP concentration is not a good marker of BHR, which is mainly dependent on asthmatic inflammation and is measured during bronchial challenge with histamine. This finding is important for interpreting and discussing results obtained from epidemiological and population-based studies on relationships between either CRP concentration and BHR or local and systemic inflammation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-007-0035-5Authors Bernard Panaszek, Wrocław Medical University Department of Internal Medicine and Allergology Traugutta 57/59 50-417 Wrocław PolandEwa Liebhart, Wrocław Medical University Department of Internal Medicine and Allergology Traugutta 57/59 50-417 Wrocław PolandJerzy Liebhart, Wrocław Medi... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=930372 Mon, 01 Oct 2007 02:42:56 +0100 930372 http://www.medworm.com/index.php?rid=930370&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F60ml41323rj13372%2F Abstract  Selenium (Se) is an essential dietary trace element that influences immune responses through its incorporation into selenoproteins as the amino acid selenocysteine. This review summarizes data available to date regarding the mechanisms by which Se exerts its effects on inflammation and immune responses. This includes the effects of Se on phagocytes as well as effects on lymphocyte activation, proliferation, and differentiation. Also examined are the known functions of individual selenoproteins for regulating reactive oxygen species and redox potential in leukocytes. Overall, determining how Se contributes to optimal immune responses will depend on a better understanding of the mechanisms by which the selenoproteins, individually and collectively, shape inflammatio... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=930370 Mon, 01 Oct 2007 02:42:56 +0100 930370 http://www.medworm.com/index.php?rid=930373&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwr3p6552x11654l2%2F Abstract  Interleukin (IL)-17 is a 30- to 35-kDa homodimeric polypeptide cytokine cloned in 1993 and originally named cytotoxic T lymphocyte-associated antigen-8 (CTLA-8). Sequencing the human genome resulted in the discovery of an additional five members of the IL-17 family that were consecutively named IL-17B to IL-17F. IL-17A is exclusively produced by a newly identified CD4+ T-helper subset that was recently named Th17. Differentiation of these cells from na�ve CD4+ T cells requires both TGF-β and IL-6. IL-15 and, especially, IL-23 are required for these cells’ survival and efficient IL-17 production. IL-17 binding to an IL-17 receptor expressed on epithelial, endothelial, and fibroblastic stromal cells triggers the activation of transcription factor NF-κB and mitog... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=930373 Mon, 01 Oct 2007 02:42:55 +0100 930373 http://www.medworm.com/index.php?rid=930371&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F520570732221728l%2F Abstract  Cytomegalovirus (CMV) is a persistent DNA virus that has evolved with humans to establish a finely balanced host-virus relationship. This balance is maintained by host immune surveillance since deficiencies in these processes can result in life-threatening disease, as observed in immunologically immature neonates and pharmacologically immunosuppressed transplant recipients. Both T cells and natural killer cells are intimately involved in maintaining asymptomatic infection by specific and non-specific recognition of infected cells. Under pressure from such host immune responses, CMV appears to have evolved elaborate strategies to subvert these responses in order to persist in the host. CMV target antigens are well characterized, with many CD8 T cell and CD4 T cell ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=930371 Mon, 01 Oct 2007 02:42:55 +0100 930371 http://www.medworm.com/index.php?rid=930369&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm7056453547416j5%2F Abstract  Terpenes are naturally occurring substances produced by a wide variety of plants and animals. A broad range of the biological properties of terpenoids is described, including cancer chemopreventive effects, antimicrobial, antifungal, antiviral, antihyperglycemic, anti-inflammatory, and antiparasitic activities. Terpenes are also presented as skin penetration enhancers and agents involved in the prevention and therapy of several inflammatory diseases. Moreover, a potential mechanism of their action against pathogens and their influence on skin permeability are discussed. The major conclusion is that larger-scale use of terpenoids in modern medicine should be taken into consideration. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00005-007-0039-1Authors ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=930369 Mon, 01 Oct 2007 02:42:55 +0100 930369 http://www.medworm.com/index.php?rid=930368&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd50043r68n5708qv%2F Abstract  Memory T cells are an important cell type in the immune system and are vital to protective immunity against invading pathogens. However, a significant fraction of memory T cells is found to be alloreactive in transplant models, i.e. they can readily attack and dismantle allografts in transplant models. As memory T cells are not as easily amenable as na�ve T cells, memory T cells constitute a potent barrier to the induction of transplant tolerance. The key issues concerning memory T cells in transplantation are related to the tolerability of alloreactive memory T cells and the effects of commonly used immunosuppressive drugs on the memory response in transplant recipients. The real challenge in the future is to selectively tolerize alloreactive memory T cells but... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=930368 Mon, 01 Oct 2007 02:42:55 +0100 930368 http://www.medworm.com/index.php?rid=930376&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc8k78tp65tp73262%2F Abstract  A promising area of investigation is the use of cancer vaccines to eliminate residual tumor cells. Dendritic cells (DCs) are potent professional antigen-presenting cells able to induce primary immune responses. DCs capture and process antigens into peptides and present them to T cells and B cells through MHC class I and II molecules. An alternative approach to the induction of antitumor immunity is the use of fusions of DCs and tumor cells. In this approach, a broad spectrum of tumor-associated antigens, including those known and unidentified, are processed endogenously and presented by MHC class I and II pathways in the context of costimulatory signals. In animal studies, vaccination with DC/tumor fusion cells results in the elimination of established lung metast... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=930376 Mon, 01 Oct 2007 02:42:54 +0100 930376 http://www.medworm.com/index.php?rid=930375&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl3xx5670w838x6l8%2F Conclusions:  The obtained results confirm the thesis of glucose toxicity and intensification of oxidative stress in patients with diabetes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-007-0033-7Authors Jacek Rysz, Medical University of Łódź 2nd Department of Family Medicine, University Hospital No. 2 Żeromskiego 113 90-549 Łódź PolandRobert Błaszczak, Medical University of Łódź 2nd Department of Family Medicine, University Hospital No. 2 Żeromskiego 113 90-549 Łódź PolandMaciej Banach, Medical University of Łódź Department of Cardiology, 1st Chair of Cardiology and Cardiac Surgery, University Hospital No. 3 Łódź PolandKornelia Kędziora-Kornatowska, Medical Academy of Bydgoszcz Department and Clinic of Geriatrics Bydgoszc... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=930375 Mon, 01 Oct 2007 02:42:54 +0100 930375 http://www.medworm.com/index.php?rid=930374&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvx83vxqx65123hn1%2F Conclusions:  The serological and structural data showed that P. mirabilis TG 83, TG 319, CCUG 10700 (OA), and O57 have the same O-antigen structure and could be qualified to the Proteus O57 serogroup. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00005-007-0040-8Authors Agnieszka Zabłotni, University of Łódź Department of General Microbiology, Institute of Microbiology and Immunology Banacha 12/16 90-237 Łódź PolandKrystyna Zych, University of Łódź Department of General Microbiology, Institute of Microbiology and Immunology Banacha 12/16 90-237 Łódź PolandAnna N. Kondakova, Russian Academy of Sciences N.D. Zelinsky Institute of Organic Chemistry Moscow Russian FederationMałgorzata Siwińska, University of Łódź Department of General M... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=930374 Mon, 01 Oct 2007 02:42:54 +0100 930374 http://www.medworm.com/index.php?rid=756535&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn5x66091113731u5%2F Conclusions:  Immunoreactivity to RAs in patients with breast cancer may also be present in cases without clinical signs of CAR. Content TypeJournal Article JournalArchivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=756535 Mon, 23 Jul 2007 18:46:56 +0100 756535 http://www.medworm.com/index.php?rid=756534&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw156534150705743%2F Abstract  Regulation of T cell homeostasis is critical for maintaining normal immune function. An imbalance in T cell proliferation can result in disorders ranging from cancer and autoimmunity to immunodeficiencies. Full activation of T cells requires three sequential signals, where signal 3, which is delivered by multiple cytokines, regulates proliferation, differentiation, and survival/death. Signaling from cytokines through their receptors is primarily delivered by two molecular families, namely Janus tyrosine kinases (JAKs) and signal transducers and activators of transcription (STATs). Invaluable knowledge about JAKs and STATs has arisen from studies of mice made genetically deficient in these molecules, analyses of tumor models, and studies of expression patterns by p... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=756534 Mon, 23 Jul 2007 18:46:56 +0100 756534 http://www.medworm.com/index.php?rid=756533&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7721023v603g4885%2F Abstract  CD8+ cytotoxic T lymphocytes (CTLs) play an important role in antitumor immunity. Induction of tumor-specific CTLs is one major strategy for tumor immunotherapy. However, therapeutic vaccinations used to treat firmly established tumors are generally ineffective. A thorough understanding of the mechanisms underlying tumor resistance to CTL-based therapeutic vaccination is very important in the tumor immunology field. There are two main mechanisms by which tumors develop resistance to CTL-based therapeutic vaccinations. One is that tumors induce peripheral tolerance of tumor-specific CD8+ T cells. The other is that tumor cells themselves develop immune evasion mechanisms to prevent recognition and killing by CTLs. This review focuses on recently reported cellular and... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=756533 Mon, 23 Jul 2007 18:46:56 +0100 756533 http://www.medworm.com/index.php?rid=756532&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6378u1275v8235p3%2F Conclusions:  This study established Bomirski Ab melanoma as a useful model for complex analysis of the anti-tumor activity of TNF. Content TypeJournal Article JournalArchivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=756532 Mon, 23 Jul 2007 18:46:56 +0100 756532 http://www.medworm.com/index.php?rid=756531&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx44355851136pu57%2F Abstract  Mast cells have long been recognized as the critical tissue-based effector cells in IgE-mediated allergic diseases. Ligation of the high-affinity receptor for IgE (FcεRI), constitutively expressed on mast cells, promotes cell activation and immediate release and production of pro-inflammatory mediators. Besides these positive signals, FcεRI aggregation has recently been understood to generate negative intracellular signals capable of limiting mast cell functional responses. This review is aimed at providing a summary of the mechanisms through which FcεRI engagement can generate negative signals and regulate mast-cell function. Similar mechanisms are employed by other receptors expressed by immune cells, such as T cell and B cell receptors, pointing to a general... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=756531 Mon, 23 Jul 2007 18:46:56 +0100 756531 http://www.medworm.com/index.php?rid=756530&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe7j3446966vu6323%2F Abstract  A special type of stem cells, defined as endothelial progenitor cells (EPCs), has been found in the bone marrow and peripheral blood. These EPCs are incorporated into injured vessels and become mature endothelial cells during re-endothelialization and neovascularization processes. Though a complete phenotypic description of EPCs remains unclear, these cells express several surface markers, the most relevant including CD34 and CD133 antigens. Furthermore, EPCs derived from other sources could also give rise to mature endothelial cells, which makes this group of cells more diverse. The recruitment of EPCs from the bone marrow to homing sites of vasculogenesis is subject to regulation by many factors, including chemokines and growth factors. The precise mechanism of ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=756530 Mon, 23 Jul 2007 18:46:56 +0100 756530 http://www.medworm.com/index.php?rid=671110&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm94x56r56200k070%2F Conclusions:  These findings underline the value of novel PCR methods used in current therapeutic procedures and in monitoring antiviral therapy with nucleoside analogs. The high level of sensitivity, specificity, accuracy, and rapidity provided by the LightCycler instrument are favorable for the use of this system in the detection of HHV-5 DNA in clinical specimens. Content TypeJournal Article JournalArchivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X Journal VolumeVolume 55 Journal IssueVolume 55, Number 3 / June, 2007 (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=671110 Fri, 08 Jun 2007 07:13:13 +0100 671110 http://www.medworm.com/index.php?rid=671111&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd06366368q1w653m%2F Conclusions:  The biological response of the cells to the structurally similar anthracyclines may be variable and probably depends on the cell type which seems to be an additional problem in the multifactorial resistance of tumor cells to anthracyclines. Content TypeJournal Article JournalArchivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X Journal VolumeVolume 55 Journal IssueVolume 55, Number 3 / June, 2007 (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=671111 Fri, 08 Jun 2007 07:13:12 +0100 671111 http://www.medworm.com/index.php?rid=671109&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5754074051350167%2F Conclusions:  Our data suggest that VEGF serum level may be a useful marker of disease activity and internal organ involvement in SLE patients. Abnormalities in nailfold capillaroscopy may reflect the extent of microvascular involvement and are associated with systemic manifestation in SLE. Content TypeJournal Article JournalArchivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X Journal VolumeVolume 55 Journal IssueVolume 55, Number 3 / June, 2007 (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=671109 Fri, 08 Jun 2007 07:13:10 +0100 671109 http://www.medworm.com/index.php?rid=671113&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvpt7013626g21057%2F Abstract.  Fork head box P3 (FoxP3+) regulatory T cells (Tregs) are specialized T cells for prevention of hyperimmune responses and autoimmunity. Tumors and pathogens can hijack FoxP3+ Tregs to evade host immune responses. There is an increasing body of evidence that trafficking of FoxP3+ Tregs is important for their effective suppression of target cells. Because of their distinctive functions and gene expression phenotype, the migratory behavior of FoxP3+ Tregs has been somewhat mystified. The myths are that they have unique trafficking receptors and migratory behaviors that are different from those of conventional T cells. Another related myth is that FoxP3+ regulatory T cell subsets have a fixed trafficking behavior from the time they are generated in the thymus. The recent... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=671113 Fri, 08 Jun 2007 07:13:08 +0100 671113 http://www.medworm.com/index.php?rid=671112&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl727vt3865505636%2F Conclusions:  Membranous epithelial cells (M cells) play a key role in the pathogenesis of CL-GPC for the binding and translocation of antigen and pathogen. Content TypeJournal Article JournalArchivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X Journal VolumeVolume 55 Journal IssueVolume 55, Number 3 / June, 2007 (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=671112 Fri, 08 Jun 2007 07:13:02 +0100 671112 http://www.medworm.com/index.php?rid=671106&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc81413023j058885%2F Abstract.  In 1970, Gershon was the first to propose that T cells, in addition to their helper activity, can also play a role as regulatory cells capable of suppressing immune responses. However, the initial strong interest in T cell-mediated suppression was followed by a period of doubt and skepticism. Since the late 1990s the “S” word started to be used in immunology again and interest in T suppressor cells has grown, ushering in a new renaissance for the field. In this article the author presents the current knowledge about a new subject called “skin-induced tolerance”. Suppression is induced via epicutaneous immunization and is described in both Th1- and Tc1-mediated contact sensitivity reactions. The subject of skin-induced tolerance is also considered in the r... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=671106 Fri, 08 Jun 2007 07:12:56 +0100 671106 http://www.medworm.com/index.php?rid=671105&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F46k006752l018376%2F Conclusions:  P. vulgaris TG 251 was classified to the Proteus O65 serogroup. Two disaccharide-associated epitopes present in P. vulgaris TG 251 and P. penneri O65 LPSs are suggested to be responsible for cross-reactions with three heterologous Proteus strains. Content TypeJournal Article JournalArchivum Immunologiae et Therapiae ExperimentalisOnline ISSN 1661-4917Print ISSN 0004-069X Journal VolumeVolume 55 Journal IssueVolume 55, Number 3 / June, 2007 (Source: Archivum Immunologiae et Therapiae Experimentalis) Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=671105 Fri, 08 Jun 2007 07:12:55 +0100 671105 http://www.medworm.com/index.php?rid=671107&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fugp542n8v14jq867%2F Abstract.  Along alternative protective pathways, human cells can synthesize biologically active proteins that interfere with HIV replication, but are not viral antigen specific. HIV is sensitive to several viral inhibitors of cellular origin, such as interferons or interferon-regulated proteins. With the progress of AIDS research it has become evident that the immune cells of some individuals are capable of restricting the virus by secretion of other, yet unidentified factor(s) that can be detected only by their potent antiviral activity. Research efforts to identify this inhibitor of HIV – a “magic bullet” released by our immune cells – have revealed the identity of several novel molecules and added to the knowledge of innate cellular responses to viral invasion. ... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=671107 Fri, 08 Jun 2007 07:12:52 +0100 671107 http://www.medworm.com/index.php?rid=671108&cid=s_33469_3_f&fid=33469&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk837w67r6843g420%2F We describe here three different approaches to the regulation of expression or activity of genes or proteins. Promoter-based regulation of gene expression was among the most rapidly developing techniques in the 1980s and 1990s. Here we provide basic information and also some characteristics of the metallothionein-promoter-based system, the tet-off system, Muristerone-A-regulated expression through the ecdysone response element, RheoSwitch, coumermycin/novobiocin-regulated gene expression, chemical dimerizer-based promoter activation systems, the “Dual Drug Control” system, “constitutive androstane receptor”-based regulation of gene expression, and RU486/mifepristone-driven regulation of promoter activity. A large part of the review concentrates on the principles and usage of v... Archivum Immunologiae et Therapiae Experimentalis journals http://www.medworm.com/rss/comments.php?id=671108 Fri, 08 Jun 2007 07:12:49 +0100 671108