MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Arhiv za Higijenu Rada i Toksikologiju' source. Mon, 30 Jan 2012 12:13:08 +0100 http://www.medworm.com/index.php?rid=5557318&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202462%26dopt%3DAbstract Authors: Eshkoor SA, Ismail P, Rahman SA, Moin S Abstract The aim of our study was to see the effects of GSTP1 polymorphism on biomarkers of ageing, including micronuclei (MN), comet tail length, and relative telomere length in automobile repair workers, who are exposed to a broad spectrum of potential mutagens. The analysis was performed on buccal cells collected from occupationally exposed and non-exposed (control) subjects. Samples were analysed using cytogenetic and molecular methods, including restriction fragment length polymorphism (RFLP), MN test, comet assay, and real-time PCR. The results confirmed the DNA damaging effects of substances used in the mechanical workshops, but did not confirm the influence of GSTP1 gene polymorphism on DNA damage. However, further studies on... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5557318 Thu, 01 Dec 2011 05:00:00 +0100 5557318 http://www.medworm.com/index.php?rid=5557317&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202463%26dopt%3DAbstract Authors: Slišković A, Seršić DM Abstract The aim of this study was to investigate exposure to stress at work in university teachers and see if there were differences between men and women as well as between positions. The study was carried out online and included a representative sample of 1,168 teachers employed at universities in Croatia. This included all teaching positions: assistants (50 %), assistant professors (18 %), associate professors (17 %), and full professors (15 %). Fifty-seven percent of the sample were women. The participants answered a questionnaire of our own design that measured six groups of stressors: workload, material and technical conditions at work, relationships with colleagues at work, work with students, work organisation, and social recognition and... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5557317 Thu, 01 Dec 2011 05:00:00 +0100 5557317 http://www.medworm.com/index.php?rid=5557316&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202464%26dopt%3DAbstract Authors: Turkez H, Geyikoglu F Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a very toxic environmental pollutant that raises great public concern about its impact on human health. Recent studies indicate that laurel leaf extract exhibits antioxidant properties that can counter the toxic effects of certain compounds in the liver. The aim of this study was to assess how effective LE is against the toxicity of TCDD in a primary culture of rat hepatocytes. The extract (50 mg L-1, 100 mg L-1, and 200 mg L-1) was added to cultures alone or with TCDD (1.61 mg L-1 and 3.22 mg L-1) for 48 hours. Cell viability was measured using the [3-(4,5-dimethyl-thiazol-2-yl) 2,5-diphenyltetrazolium bromide] (MTT) assay and the lactate dehydrogenase (LDH) cytotoxicity assay, while oxidative da... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5557316 Thu, 01 Dec 2011 05:00:00 +0100 5557316 http://www.medworm.com/index.php?rid=5557315&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202465%26dopt%3DAbstract The objective of this study was to examine and compare the acute toxicity and cholinesterase inhibition in seven to 14-day-old chicks dosed orally with dichlorvos and diazinon in standard veterinary and agricultural formulations. The acute (24 h) oral median lethal doses (LD50) of the formulations were determined using the up-and-down method. Respective LD50 of dichlorvos of the veterinary and agricultural formulations in chicks were 11.1 mg kg-1 and 6.51 mg kg-1 and those of diazinon 6.4 mg kg-1 and 6.7 mg kg-1. Plasma and brain cholinesterase activities were measured by electrometry after in vivo and in vitro exposure to organophosphates. The chicks showed signs of cholinergic toxicosis within one hour of dosing. Dichlorvos (8 mg kg-1) and diazinon (4 mg kg-1) in the veterinary and agric... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5557315 Thu, 01 Dec 2011 05:00:00 +0100 5557315 http://www.medworm.com/index.php?rid=5557314&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202466%26dopt%3DAbstract Authors: Gvozdić V, Brana J, Puntarić D, Vidosavljević D, Roland D Abstract The goal of this study was to analyse 13 physico-chemical and microbiological parameters of the Drava River water at three sampling sites in the lower Drava region (eastern Croatia) over two distinct periods: the pre-war period between 1985 and 1992 and the post-war period between 1993 and 2008. Over both periods, most parameters kept within the tolerable water quality limits, while NO3-N, NH4-N and BOD5 were higher. The lower Drava showed slight organic pollution with high concentrations of dissolved oxygen. High levels of total coliforms and heterotrophic bacteria in the post-war period were only found downstream of the town of Osijek. Upstream of Osijek, the river showed a tendency for improvement. ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5557314 Thu, 01 Dec 2011 05:00:00 +0100 5557314 http://www.medworm.com/index.php?rid=5557313&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202467%26dopt%3DAbstract Authors: Rakić A, Perić J, Stambuk-Giljanović N, Mikrut A, Bakavić AS Abstract The purpose of this study was to compare the quality of hot water between eleven hotels in the Split-Dalmatia County, Croatia that are open year round and 10 summer season hotels and retirement homes with irregular use of water. We took 122 samples between May and December 2009. Water temperature and free residual chlorine were measured in situ. Physical and chemical analysis included pH, electrical conductivity, and concentrations of iron, manganese, copper, zinc, calcium, and magnesium that were measured using atomic absorption spectrophotometry, while the Legionella species were determined using a cultivation method on buffered charcoal yeast extract agar.Differences in metal concentrations betwee... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5557313 Thu, 01 Dec 2011 05:00:00 +0100 5557313 http://www.medworm.com/index.php?rid=5557312&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202468%26dopt%3DAbstract Authors: Perić A, Vojvodić D, Vukomanović-Đurđević B, Baletić N Abstract On histopathological examination, nasal polyps and nasal mucosa in allergic rhinitis show different forms of pseudostratified respiratory epithelium, whereas the dominant characteristic of lamina propria is an eosinophilic infiltration. The aim of this study was to compare interleukin (IL)-5 and eosinophilic cationic protein (ECP) levels in the nasal fluid of 42 patients: 12 with allergic rhinitis and nasal septal deviation, 17 non-atopic patients with nasal polyposis, and 13 atopic nasal polyp patients were enrolled in this cross-sectional study. Nasal secretion samples were collected a few days before surgery. The levels of IL-5 were measured using flow cytometry and the ECP using a commercial ELISA k... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5557312 Thu, 01 Dec 2011 05:00:00 +0100 5557312 http://www.medworm.com/index.php?rid=5557311&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202469%26dopt%3DAbstract Authors: Knežević ZM, Nadih M, Josipović R, Grgić I, Cvitković A Abstract On 21 September 2008, heavy oil penetrated the drinking water supply in Slavonski Brod, Croatia. The accident was caused by the damage of heat exchange units in hot water supply. The system was polluted until the beginning of November, when the pipeline was treated with BIS O 2700 detergent and rinsed with water. Meanwhile, water samples were taken for chemical analysis using spectrometric and titrimetric methods and for microbiological analysis using membrane filtration and total plate count. Mineral oils were determined with infrared spectroscopy. Of the 192 samples taken for mineral oil analysis, 55 were above the maximally allowed concentration (MAC). Five samples were taken for polycyclic aromatic h... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5557311 Thu, 01 Dec 2011 05:00:00 +0100 5557311 http://www.medworm.com/index.php?rid=5557310&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202470%26dopt%3DAbstract Authors: Jakovljević I, Zužul S Abstract Polycyclic aromatic hydrocarbons (PAHs) are a large group of organic compounds consisting of two or more condense aromatic rings. They are products of incomplete combustion or pyrolysis of organic matter. Because some PAHs such as Benzo[a]pyrene (BaP) are proven carcinogens and mutagens, it is necessary to continuously monitor their concentrations in the air, water, and soil. PAHs with two or three aromatic rings are stable in the gas phase, while most PAHs with five or more aromatic rings bond to particles. Higher concentrations of PAHs are present in the atmosphere of urban areas, mostly in the winter, due to heating. In the summer, these concentrations drop because most PAHs are unstable at high temperatures and break down by oxidation ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5557310 Thu, 01 Dec 2011 05:00:00 +0100 5557310 http://www.medworm.com/index.php?rid=5557309&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202471%26dopt%3DAbstract Authors: Prester L Abstract Humid indoor environments may be colonised by allergenic filamentous microfungi (moulds), Aspergillus spp., Penicillium spp., Cladosporium spp., and Alternaria spp. in particular. Mould-induced respiratory diseases are a worldwide problem. In the last two decades, mould allergens and glucans have been used as markers of indoor exposure to moulds. Recently, mould allergens Alt a 1 (Alternaria alternata) and Asp f 1 (Aspergillus fumigatus) have been analysed in various environments (residential and occupational) with enzyme-linked immunosorbent assays, which use monoclonal or polyclonal antibodies. Household Alt a 1 and Asp f 1 levels were usually under the limit of the method detection. By contrast, higher levels of mould allergens were found in environme... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5557309 Thu, 01 Dec 2011 05:00:00 +0100 5557309 http://www.medworm.com/index.php?rid=5557308&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202472%26dopt%3DAbstract Authors: Batra T PMID: 22202472 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5557308 Thu, 01 Dec 2011 05:00:00 +0100 5557308 http://www.medworm.com/index.php?rid=5292608&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971102%26dopt%3DAbstract Authors: Kovarik Z PMID: 21971102 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292608 Thu, 01 Sep 2011 04:00:00 +0100 5292608 http://www.medworm.com/index.php?rid=5292607&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971103%26dopt%3DAbstract Authors: Engin AB, Karahalil B, Karakaya AE, Engin A Abstract Gastric cancer is one of the most common cancers of the gastrointestinal system, and its overall five-year survival rate is still 15 % to 20 %, as it can mostly be diagnosed at an advanced stage. On the other hand, although colorectal cancer has a rather good prognosis, mortality is one half that of the incidence.As carcinogenesis is believed to involve reactive radicals that cause DNA adduct formation, impaired repair activity, and weakened tumour suppression, it would help to understand the role of the polymorphisms of nucleotide excision repair enzyme XRCC1 and of tumour suppressor gene p53 in gastric and colorectal cancers. Our study included 94 gastric cancer patients, 96 colorectal cancer patients, and 108 cancer-f... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292607 Thu, 01 Sep 2011 04:00:00 +0100 5292607 http://www.medworm.com/index.php?rid=5292606&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971104%26dopt%3DAbstract Authors: Bilandžić N, Varenina I, Tanković S, Kolanović BS Abstract Chloramphenicol muscle residue levels in rainbow trout were determined after oral administration of 84 μg kg-1d-1 of chloramphenicol for four days. Samples were taken one day before treatment and for 43 days after the treatment was over. Chloramphenicol was analysed using an in-house enzyme linked immunoassay (ELISA) validated against the criteria of the Commission Decision 2002/657/EC. Validation parameters confirmed that the method was appropriate for the detection of chloramphenicol at levels below the minimum required performance limit (MRPL) of 0.3 μg kg-1. The highest chloramphenicol levels were observed on the first day after the treatment had ended (144.3 μg kg-1). Elimination was significant over th... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292606 Thu, 01 Sep 2011 04:00:00 +0100 5292606 http://www.medworm.com/index.php?rid=5292605&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971105%26dopt%3DAbstract Authors: Durgo K, Halec I, Sola I, Franekić J Abstract Quercetin is the main flavonoid in diet with a potential in the treatment of cancer, cardiovascular, and neurodegenerative diseases. Due to its specific planar chemical structure, quercetin readily forms chelates with metal ions. Complexes of bioactive compounds and metal ions such as lanthanum often show strong cytotoxic and antitumour properties. The aim of this study was to compare the genotoxic effects of the quercetin/lanthanum complex on human cervical carcinoma cells with compare it to the effects of free ligands, quercetin, and lanthanum alone. The quercetin/lanthanum complex showed considerable cytotoxicity in the concentration range of (100 to 1000) mmol mL-1 and exposure time of three hours. The complex also induced... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292605 Thu, 01 Sep 2011 04:00:00 +0100 5292605 http://www.medworm.com/index.php?rid=5292604&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971106%26dopt%3DAbstract Authors: Tariba B, Kljaković-Gašpić Z, Pizent A Abstract To estimate Cu exposure level from wine consumption and to assess possible health risk for moderate wine consumers, wine samples were collected from different wine-growing areas of Croatia. Median concentrations were 180 μg L-1, range (76 to 292) μg L-1, in commercial wines and 258 μg L-1, range (115 to 7600) μg L-1, in homemade wines (P>0.05). Maximum permitted level of 1000 μg L-1 was exceeded in three homemade wines. However, daily intake of Cu from wine (in the range from 0.02 mg d-1 to 1.52 mg d-1) estimated from Cu concentration in all wine samples is lower than the tolerable upper intake level of 5 mg d-1 proposed by the EU Scientific Committee on Food and does not present a risk to moderate wine consumers. ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292604 Thu, 01 Sep 2011 04:00:00 +0100 5292604 http://www.medworm.com/index.php?rid=5292603&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971107%26dopt%3DAbstract This study shows that adjuvant radiotherapy of the para-aortic lymph nodes with the total dosage of 24 Gy in 16 daily fractions administered to testicular seminoma patients causes acceptable side effects, does not adversely affect quality of life and fertility, if the approach to treatment is individual and family consulting is provided. This makes adjuvant radiotherapy of the para-aortic lymph nodes an acceptable treatment for testicular seminoma stage I patients. PMID: 21971107 [PubMed - as supplied by publisher] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292603 Thu, 01 Sep 2011 04:00:00 +0100 5292603 http://www.medworm.com/index.php?rid=5292602&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971108%26dopt%3DAbstract Authors: Ajoudanifar H, Hedayati MT, Mayahi S, Khosravi A, Mousavi B Abstract The aim of this study was to assess the volume of airborne fungi in the indoor and outdoor environment of poultry and cattle houses in the Mazandaran Province in Iran. Indoor and outdoor air of twenty cattle houses and twenty-five poultry houses were sampled using a single-stage impactor, which draws air at 20 L min-1 and impacts sampled material onto Petri plates containing malt extract agar. The plates were incubated at 30 °C for seven days, after which the resulting colonies were counted. The fungi were identified and counted microscopically and macroscopically. A total of 4,662 fungal colonies were isolated from 90 plates collected from indoor and outdoor air of cattle and poultry houses. Cladosporiu... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292602 Thu, 01 Sep 2011 04:00:00 +0100 5292602 http://www.medworm.com/index.php?rid=5292601&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971109%26dopt%3DAbstract Authors: Kalambura S, Voća N, Krička T, Sindrak Z, Spehar A, Kalambura D Abstract Biodegradable waste is by definition degraded by other living organisms. Every day, meat industry produces large amounts of a specific type of biodegradable waste called slaughterhouse waste. Traditionally in Europe, this waste is recycled in rendering plants which produce meat and bone meal and fat. However, feeding animals with meat and bone meal has been banned since the outbreaks of bovine spongiform encephalopathy (BSE). In consequence, new slaughterhouse waste processing technologies have been developed, and animal wastes have now been used for energy production. Certain parts of this waste, such as brains and spinal cord, are deemed high-risk substances, because they may be infected with prio... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292601 Thu, 01 Sep 2011 04:00:00 +0100 5292601 http://www.medworm.com/index.php?rid=5292599&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971110%26dopt%3DAbstract Authors: Jurković S, Diklić A, Kasabašić M, Radojčić DS, Svabić M, Ivković A, Faj D Abstract Implementation of advanced radiation therapy techniques in clinical practice can greatly improve tumour control and normal tissue sparing. An important part of this implementation is quality control (QC) of every part of the radiotherapy process, as it helps to detect errors and provides instant remedy. This increases the probability of successful radiation treatment and ensures patient radiation safety. Every radiotherapy quality assurance (QA) programme is based on quality control of radiotherapy equipment. The aim of our survey was to review QC practices in a number of radiotherapy centres in Croatia. As a first step, we defined a set of tests to check different parameters of lin... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292599 Thu, 01 Sep 2011 04:00:00 +0100 5292599 http://www.medworm.com/index.php?rid=5292592&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971111%26dopt%3DAbstract Authors: Kasabašić M, Rajevac V, Jurković S, Ivković A, Sobat H, Faj D Abstract An external beam radiotherapy (EBRT) using megavoltage beam of linear accelerator is usually the treatment of choice in cancer patients. The goal of EBRT is to deliver the prescribed dose to the target volume, with as low as possible dose to the surrounding healthy tissue. A large number of procedures and different professions involved in radiotherapy, uncertainty of equipment and daily patient set-up errors can cause a difference between the planned and delivered dose.We investigated a part of this difference caused by measuring daily patient set-up errors for 35 patients. These set-up errors were simulated on five patients, using 3D treatment planning software XiO. The simulation investigated diff... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292592 Thu, 01 Sep 2011 04:00:00 +0100 5292592 http://www.medworm.com/index.php?rid=5292591&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971112%26dopt%3DAbstract Authors: Knežević Z, Serdar M Abstract This review presents methods for the assessment of acute and chronic risk from pesticide residues in food. Multiple pesticide residues can often be found in food. Currently, there is no internationally accepted procedure for the assessment of cumulative exposure to multiple pesticide residues in food. Therefore, risk assessment is based on toxicological evaluation of single compounds in a food matrix. The international estimation of short-term intake model (IESTI) has been used to calculate acute intake. IESTI is based on "the worst-case scenario" and addresses the possibility that consumers sometimes eat large amounts of a food item, and such a large amount might contain residues at highest levels. However, it should take into account uneve... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292591 Thu, 01 Sep 2011 04:00:00 +0100 5292591 http://www.medworm.com/index.php?rid=5292590&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21971113%26dopt%3DAbstract Authors: Hanžek B, Franić Z, Branica G Abstract Physicists and chemists were among the first potential victims of occupational exposure to ionising radiation and they were also the first to warn about the harmful effects of radiation on living organisms. This review presents the work of the first notable scientists in the field of radiation science in Croatia from the discovery of radiation (Henry Becquerel in 1896) to 1945. The beginning of radiation science and radiation protection in Croatia can be traced to the end of the 19th century. Our research of the archived material and literature not only gave a deeper insight to the life and work of some of these notable scientists, but also gave a glimpse of previously unknown facts and details important for the history and developm... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=5292590 Thu, 01 Sep 2011 04:00:00 +0100 5292590 http://www.medworm.com/index.php?rid=4992241&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705298%26dopt%3DAbstract Authors: Türkan H, Aydin A, Sayal A, Eken A, Akay C, Karahalil B General anaesthetics are often used in patients who are under oxidative stress due to a critical illness or surgical trauma. Some anaesthetics may worsen oxidative stress and some may act as antioxidants. The aim of this study was to evaluate liver, brain, kidney, and lung tissue oxidative stress in rats exposed to desflurane and sevoflurane and in unexposed rats. The animals were divided in three groups: control (received only air); sevoflurane (8 %), and desflurane (4 %). After four hours of exposure, we evaluated the levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), Cu, and Zn. Exposure to either of the anaesthetics significantly increased lung MDA levels compared to control... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4992241 Tue, 31 May 2011 23:00:00 +0100 4992241 http://www.medworm.com/index.php?rid=4992240&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705299%26dopt%3DAbstract In this study we evaluated the toxicological effects of o-cresol on differential gene expression profile of rat liver and prostate. Experiments were conducted on 80 male rats, 60 of which were exposed to o-cresol (1.5 g kg-1, 5 g kg-1, or 15 g kg-1) through feed for 8 weeks. Three groups of rats were supplemented with 0.1 mg kg-1 selenium (Se, in the form of, sodium selenite) in addition to o-cresol to evaluate its effectiveness against o-cresol toxicity. Control group received neither o-cresol nor Se, while one group received Se alone. Survival was similar between the exposed and control animals. Rats exposed to 15 g kg-1 of o-cresol showed a 16 % loss in body weight by the end of the study, which may have been related to o-cresol making feed unpalatable at this concentration. Liver and p... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4992240 Tue, 31 May 2011 23:00:00 +0100 4992240 http://www.medworm.com/index.php?rid=4992239&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705300%26dopt%3DAbstract Authors: Vitcheva V, Simeonova R, Karova D, Mitcheva M The aim of this study was to see how nifedipine counters the effects of cocaine on hepatic and brain enzymatic activity in rats and whether it affects urinary excretion of cocaine. Male Wistar rats were divided in four groups of six: control, nifedipine group (5 mg kg-1i.p. a day for five days); cocaine group (15 mg kg-1i.p. a day for five days), and the nifedipine+cocaine group. Twenty-four hours after the last administration, we measured neuronal nitric oxide synthase (nNOS) activity in the brain and cytochrome P450 quantity, ethylmorphine-N-demethylase, and anilinehydroxylase activity in the liver. Urine samples were collected 24 h after the last cocaine and cocaine+nifedipine administration. Urinary cocaine concentration was de... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4992239 Tue, 31 May 2011 23:00:00 +0100 4992239 http://www.medworm.com/index.php?rid=4992238&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705301%26dopt%3DAbstract In this study, we evaluated the potential cytotoxic and prooxidative effects of green tea extract and its two main flavonoid constituents epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) on human laryngeal carcinoma cell line (HEp2) and its cross-resistant cell line CK2. The aim was to see if the extract and its two flavonoids could increase the sensitivity of the cisplatin-resistant cell line CK2 in comparison to the parental cell line. The results show that EGCG and green tea extract increased the DNA damage in the CK2 cell line during short exposure. The cytotoxicity of EGCG and ECG increased with the time of incubation. Green tea extract induced lipid peroxidation in the CK2 cell line. The pro-oxidant effect of green tea was determined at concentrations higher than those f... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4992238 Tue, 31 May 2011 23:00:00 +0100 4992238 http://www.medworm.com/index.php?rid=4992237&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705302%26dopt%3DAbstract Authors: Barkur RR, Rao MS, Bairy LK This follow-up study investigated the effects of low-level lead exposure during prenatal and early postnatal period on learning and memory in rats immediately after exposure has ceased at weaning and later in their adulthood. Male Wistar-derived rats were exposed to lead (as 0.2 % lead acetate solution) through their mothers during pregnancy and lactation until they were weaned. Mothers of control rats were given tap water during pregnancy and lactation. All pups were weaned on tap water at 21 days of age and were followed up until 120 days old. Low-level lead exposure did not affect their body weight at any time during the experiment. Blood lead in the exposed rats was significantly higher on postnatal day 22 and dropped to control values by day 12... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4992237 Tue, 31 May 2011 23:00:00 +0100 4992237 http://www.medworm.com/index.php?rid=4992236&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705303%26dopt%3DAbstract Authors: Bogović A, Nižetić J, Galić N, Zelježić D, Micek V, Mladinić M The aim of this study was to investigate the effects and efficiency of pulp capping preparations based on hyaluronic acid, calcium hydroxide, and dentin adhesive on the pulp tissue of Sprague-Dawley rats. The rats were killed and extracted teeth sectioned transversely through the pulp. The slices were placed in a RPMI 1640 cell culture medium supplemented with 10 % foetal calf serum. During 14 days of cultivation cultures were treated with preparations that contained hyaluronic acid (Gengigel Prof®), and calcium hydroxide (ApexCal®), or with dentin adhesive (Excite®). Cellularity and viability of fibroblasts and odontoblasts was analysed using a haemocytometer. Hyaluronic acid proved most efficient and th... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4992236 Tue, 31 May 2011 23:00:00 +0100 4992236 http://www.medworm.com/index.php?rid=4992235&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705304%26dopt%3DAbstract This article presents a case with a 48-year-old male patient, who was admitted for work ability assessment due to polymorphic symptoms. The patient had been working as a salesman for 28 years. A detailed interview and examination by occupational health and other medical specialists revealed that the patient had been suffering from Wilson's disease from the age of 13, and had now developed hepatic manifestations (compensated liver cirrhosis with portal hypertension), neurological manifestations (dystonia, dysarthria, muscle weakness, vertigo), and psychiatric manifestations (depression, insomnia, cognitive impairment) of the disease, including problems partially caused by long-lasting treatment with copper chelating agents (neurological and haematological manifestations). There were no ocul... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4992235 Tue, 31 May 2011 23:00:00 +0100 4992235 http://www.medworm.com/index.php?rid=4992234&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705305%26dopt%3DAbstract Authors: Serdar M, Knežević Z This paper presents two high performance liquid chromatographic (HPLC) methods used for the separation and determination of artificial sweeteners aspartame, acesulphame K, sodium saccharin, and sodium cyclamate in beverages and special nutritional products (special food intended for specific population groups). All four compounds are soluble in aqueous solutions and can easily be separated and determined by HPLC with a diode array detector (DAD). The first method involved separation of aspartame, acesulphame K, and sodium saccharin on a C18 column with an isocratic elution of phosphate buffer and acetonitrile as mobile phase. The second method was used to separate sodium cyclamate on a C18 column with methanol and water as mobile phase. Under optimum con... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4992234 Tue, 31 May 2011 23:00:00 +0100 4992234 http://www.medworm.com/index.php?rid=4992233&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705306%26dopt%3DAbstract Authors: Bosak A, Katalinić M, Kovarik Z Enzymes acetylcholinesterase (AChE; E.C. 3.1.1.7) and butyrylcholinesterase (BChE; E.C. 3.1.1.8) have intensively been investigated in biomedicine and toxicology due to important role in organisms. Even if structurally homologous, they differ in catalytic activity, specificity, for substrates, and selectivity in binding to many ligands. This paper compiles the results of research on cholinesterases and their interactions with ligands and inhibitors, and identifies amino acids of active sites involved in these interactions. PMID: 21705306 [PubMed - as supplied by publisher] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4992233 Tue, 31 May 2011 23:00:00 +0100 4992233 http://www.medworm.com/index.php?rid=4992232&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21705307%26dopt%3DAbstract Authors: Mendaš G Triazine herbicides are very common and only 0.1 % reach the target pests, while the rest moves into other environmental compartments. Their fate in the environment depends on their movement through the air, water, and soil and on the rate of their degradation or transformation. Triazine compounds may be transformed by water, microorganisms, and sunlight. Widespread use and persistence of triazine herbicides in soil has resulted in contamination of surface, drinking, and even rain water with parent compounds and degradation products, posing a risk to the general population.The metabolism and effects of triazine herbicides have been studied in experimental animals and in experiments in vitro. There are only a few studies of their metabolism and excretion in humans. Ag... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4992232 Tue, 31 May 2011 23:00:00 +0100 4992232 http://www.medworm.com/index.php?rid=4625514&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421526%26dopt%3DAbstract Authors: PMID: 21421526 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625514 Tue, 01 Mar 2011 00:00:00 +0100 4625514 http://www.medworm.com/index.php?rid=4625513&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421527%26dopt%3DAbstract Authors: Sevgiler Y, Karaytug S, Karayakar F We investigated the muscle tissue of a teleost Cyprinus carpio L. to find out whether N-acetylcysteine (NAC), alpha-lipoic acid (LA), taurine (TAU), and curcumin (CUR) were able to counteract oxidative stress induced by acute exposure to cadmium (Cd). The muscle tissue was dissected 96 h after a single intraperitoneal injection of Cd (5 mg kg-1) and of antioxidant substances (50 mg kg-1). Using spectrophotometry, we determined the glutathione redox status, lipid peroxidation levels and the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione disulphide reductase (GR). Accumulation of Cd in the muscle was analysed using inductively coupled plasma - optical emission spectrometry (ICP-OES).All ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625513 Tue, 01 Mar 2011 00:00:00 +0100 4625513 http://www.medworm.com/index.php?rid=4625512&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421528%26dopt%3DAbstract Authors: Vuković Z, Marković L, Radenković M, Vuković D, Stanković S The aim of this study was to establish microbial and heavy metal pollution of the Sava River at three locations close to industry and urban areas (Šabac, Obrenovac, Beograd) in Serbia. Heavy metal analysis included Cu, Zn, Pb, and Cd in the river water and sediment samples. Using the microbiological analysis we tried to establish the effectiveness of total coliforms, faecal coliforms and Escherichia coli in detecting pollution of surface waters. We found that E. coli levels steadily increased downstream from Šabac (location 1; 2100 MPN per 100 mL) to Belgrade (location 3; 10000 MPN per 100 mL). To prevent bacterial contamination, it is necessary to reduce the discharge of wastewater with faecal matters near hig... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625512 Tue, 01 Mar 2011 00:00:00 +0100 4625512 http://www.medworm.com/index.php?rid=4625511&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421529%26dopt%3DAbstract This article brings the results of a method for quality assurance in gamma-ray spectrometry of seabed sediments. Sediments were collected in selected locations of the South and Middle Adriatic Sea using grab and corer tools. Using our own experimental design, we determined the self-attenuation factors of selected samples. The article also discusses sources of uncertainty in gamma-ray spectrometry, which is another important issue in quality assurance. Together with self-attenuation correction sources of uncertainty are used to calculate the activity concentration for a given sample. The presented procedure demonstrates how a gamma-ray spectrometry experiment should be approached in order to properly account for errors and uncertainties specific to a particular sample. PMID: 21421529 [P... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625511 Tue, 01 Mar 2011 00:00:00 +0100 4625511 http://www.medworm.com/index.php?rid=4625510&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421530%26dopt%3DAbstract Authors: Tariba B, Pizent A, Kljaković-Gašpić Z A method has been developed for direct determination of lead in wine by graphite furnace atomic absorption spectrometry (GFAAS) with Zeeman-effect background correction. The thermal behaviour of Pb during pyrolysis and atomisation stages was investigated without matrix modifier and in the presence of Pd(NO3)2, Pd(NO3)2 + Mg(NO3)2 × 6H2O, and NH4H2PO4 + Mg(NO3)2 × 6H2O as matrix modifiers. A simple 1:1 dilution of wine samples with Pd(NO3)2 as a matrix modifier proved optimal for accurate determination of Pb in wine. Mean recoveries were 106 % for red and 114 % for white wine, and the detection limit was 3 μg L-1. Within-run precision of measurements for red and white wine was 2.1 % and 1.8 %, respectively. The proposed method was ap... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625510 Tue, 01 Mar 2011 00:00:00 +0100 4625510 http://www.medworm.com/index.php?rid=4625509&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421531%26dopt%3DAbstract Authors: Prester L, Macan J Cockroach allergy is a health problem in many parts of the world. In urban environments, indoor exposure to cockroach allergens involves a risk of asthma. The aim of this study was to measure the mass fraction of Bla g 1, a major allergen of the German cockroach (Blatella germanica) in 30 house samples, collected at random from Zagreb area households, Croatia. Dust samples were collected on cellulose filters by vacuuming living rooms floors. After extraction, Bla g 1 was detected using the commercial enzyme-linked immunosorbent assay (ELISA). Only four of the thirty households had detectable Bla g 1 levels, and only in one was its concentration higher than 2.0 U g-1, the threshold associated with sensitisation. The Bla g 1 ELISA proved highly sensitive, with... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625509 Tue, 01 Mar 2011 00:00:00 +0100 4625509 http://www.medworm.com/index.php?rid=4625508&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421532%26dopt%3DAbstract Authors: Kosalec I, Ramić S, Jelić D, Antolović R, Pepeljnjak S, Kopjar N Tryptophol is an aromatic alcohol and secondary metabolite of the opportunistic fungus Candida albicans. Although its toxicity profile at cell level has been poorly investigated, recent data point to cytotoxic, cytostatic, and genotoxic effects in lymphocytes and the induction of apoptosis in leukaemic blood monocytes. In this pilot study we evaluated the genotoxicity of tryptophol in vitro on four permanent cell lines of animal and human origin: ovary cells, alveolar epithelium, liver cells, and blood monocytes using the alkaline comet assay. We selected cells that might be principal targets of tryptophol and other low-molecular geno(toxins) secreted by Candida albicans during host invasion. Our results sugge... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625508 Tue, 01 Mar 2011 00:00:00 +0100 4625508 http://www.medworm.com/index.php?rid=4625507&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421533%26dopt%3DAbstract Authors: Gamulin M, Katić J, Milić M, Grgić M, Fučić A The rate of genome damage elimination after therapeutic exposure to ionising radiation was estimated in stage I testicular seminoma patients monitored over a seven-year follow-up. DNA damage elimination in peripheral lymphocytes of ten subjects was analysed by the chromosome aberration assay. Seven years after the end of radiotherapy, significantly increased frequency of ring and dicentric chromosomes was still detected in comparison with baseline values. These results indicate the induction of genome instability. Long-term follow-up studies of cancer patients after radiotherapy could give us valuable information on the rate of genome damage elimination after exposure to ionising radiation and about the duration and manifestat... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625507 Tue, 01 Mar 2011 00:00:00 +0100 4625507 http://www.medworm.com/index.php?rid=4625506&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421534%26dopt%3DAbstract Authors: Miše K, Vučković M, Jurčev-Savičević A, Gudelj I, Perić I, Miše J Pulmonary diseases are well documented and diverse in many patients with HIV in clinical stages 3 and 4. It is not unusual that these patients, most of whom do not know that they are already HIV-infected, are first examined and hospitalised by respiratory medicine specialists. While HIV-infection is relatively simple to diagnose if accompanied by advanced clinical manifestations and is regularly checked in patients with increased risk, this is not the case in low-risk patients, particularly in countries with low-level HIV epidemic and therefore low index of suspicion. Regular examination involves a series of tests, often including bronchoscopy with transbronchal lung biopsy in order to identify an inters... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625506 Tue, 01 Mar 2011 00:00:00 +0100 4625506 http://www.medworm.com/index.php?rid=4625505&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421535%26dopt%3DAbstract This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has beneficial effect under condition of cadmium exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective role of magnesium during cadmium exposure. These findings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden. PMID: 21421535 [PubMed - as supplied by publisher] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625505 Tue, 01 Mar 2011 00:00:00 +0100 4625505 http://www.medworm.com/index.php?rid=4625504&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421536%26dopt%3DAbstract Authors: Klinčić D, Romanić SH This review presents methods for the analysis of hydroxylated metabolites of polycyclic aromatic hydrocarbons and polychlorinated biphenyls in humans and animals. These metabolites serve as biomarkers of human and animal exposure to the mentioned pollutants, but some metabolites also have toxic properties. Most are analysed in urine, which is the most accessible sample, but they can also be analysed in human and animal liver, bile, and adipose tissue.Their analysis is important for assessing bioavailability of aromatic pollutants and their toxicity in human organism, but also the toxicity of metabolites themselves. Advancements in analytical methods have made it possible to analyse multiple metabolites in a sample at the same time. New extraction techn... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625504 Tue, 01 Mar 2011 00:00:00 +0100 4625504 http://www.medworm.com/index.php?rid=4625503&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21421537%26dopt%3DAbstract Authors: Gudelj I, Hrenović J, Dragičević TL, Delaš F, Soljan V, Gudelj H Intense industrial development has been accompanied by the production of wastewaters of very complex content, which pose a serious hazard to the environment, put at risk sustainable development, and call for new treatment technologies that would more effectively address the issue. One particular challenge in terms of science and technology is how to biodegrade xenobiotics such as azo dyes, which practically do not degrade under natural environmental conditions. These compounds tend to bioaccumulate in the environment, and have allergenic, carcinogenic, mutagenic, and teratogenic properties for humans. Removal of azo dyes from effluents is mostly based on physical-chemical methods. These methods are often very... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4625503 Tue, 01 Mar 2011 00:00:00 +0100 4625503 http://www.medworm.com/index.php?rid=4386553&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21183429%26dopt%3DAbstract Authors: Roškar R, Dolenc MS The aim of this study was to validate a new method for determining benzodiazepines in urine via their benzophenone derivatives, based on liquid chromatography-tandem mass spectrometry (LC-MS/MS). Selected benzodiazepines were analysed after acid hydrolysis of urine and extraction by ethyl acetate in the presence of an internal standard. Samples were analysed using electrospray ionization LC-MS/MS in a multiple reaction monitoring mode. The chromatographic run time on a reversed phase C18 analytical column was set for 9 min. This method was validated in 21 patients receiving methadone. Benzodiazepines intake was established in two out of three patients. LC-MS/MS results were also compared with the rapid immunoassay and the methods showed good agreement. How... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4386553 Wed, 01 Dec 2010 00:00:00 +0100 4386553 http://www.medworm.com/index.php?rid=4386552&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21183430%26dopt%3DAbstract In conclusion, increase in biogenic amine levels is species-specific. Endotoxin analysis could be used for rapid assessment of microbiological quality of cephalopods and shellfish. PMID: 21183430 [PubMed - as supplied by publisher] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4386552 Wed, 01 Dec 2010 00:00:00 +0100 4386552 http://www.medworm.com/index.php?rid=4386551&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21183431%26dopt%3DAbstract Authors: Dragičević TL, Hren MZ, Gmajnić M, Pelko S, Kungulovski D, Kungulovski I, Cvek D, Frece J, Markov K, Delaš F Olive oil production generates large volumes of wastewater. These wastewaters are characterised by high chemical oxygen demand (COD), high content of microbial growth-inhibiting compounds such as phenolic compounds and tannins, and dark colour. The aim of this study was to investigate biodegradation of olive mill wastewater (OMW) by yeasts Trichosporon cutaneum and Geotrichum candidum. The yeast Trichosporon cutaneum was used because it has a high potential to biodegrade phenolic compounds and a wide range of toxic compounds. The yeast Geotrichum candidum was used to see how successful it is in biodegrading compounds that give the dark colour to the wastewater. Unde... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4386551 Wed, 01 Dec 2010 00:00:00 +0100 4386551 http://www.medworm.com/index.php?rid=4386550&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21183432%26dopt%3DAbstract Authors: Simić N, Tokić A, Peričić M Various studies have shown fluctuations in task performance during the menstrual cycle. The aim of this study was to see the effects of the menstrual cycle on performing fine motor and spatial tasks of different level of complexity in twenty students aged 18 to 21 years, with regular menstrual cycle (28 to 30 days). The students performed O'Connor Finger Dexterity Test and mental rotation test during the menstrual, late follicular, and midluteal phase. Before the tests were performed, we administered Spielberger's State-Trait Anxiety Inventory for each phase. After the tasks were completed, the subjects ranked their difficulty on Borg's scale.The results showed the best performance in both tests in the midluteal phase (with sex hormones at their... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4386550 Wed, 01 Dec 2010 00:00:00 +0100 4386550 http://www.medworm.com/index.php?rid=4386549&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21183433%26dopt%3DAbstract Authors: Karadžinska-Bislimovska J, Minov J, Stoleski S, Mijakoski D, Risteska-Kuc S, Milkovska S To assess health risks in agricultural workers associated with environmental exposure to pollutants released from a petroleum refinery and from traffic, we performed a cross-sectional study that included 119 randomly selected subjects divided in two groups. Group 1 included 60 agricultural workers living in a rural community near the petroleum refinery and a motorway overpass, whereas Group 2 consisted of 59 agricultural workers performing similar activities and living in a rural community with no exposure to industrial and traffic pollutants. Risk assessment included a questionnaire, blood pressure measurement, spirometry, laboratory tests, and toxicological analysis. The groups showed a... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4386549 Wed, 01 Dec 2010 00:00:00 +0100 4386549 http://www.medworm.com/index.php?rid=4386548&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21183434%26dopt%3DAbstract Authors: Tomić S, Sučić AF, Martinac AI In every country, a manufacturer of medicinal products for either human or veterinary use is required to operate in compliance with local legislation. In all EU Member States, legislation is approximated to the effect that they are committed to abide by the same standards. The candidate countries transpose the acquis into their national legislation, including the good manufacturing practice (GMP). Consequently, the local manufacturer is required to strictly comply with GMP and the manufacturing licence, including for medicinal products exclusively intended for export. A vital role is also played by national regulatory authorities, in Croatia by the Agency for Medicinal Products and Medical Devices which issues the manufacturing licence, GMP ce... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4386548 Wed, 01 Dec 2010 00:00:00 +0100 4386548 http://www.medworm.com/index.php?rid=4386547&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21183435%26dopt%3DAbstract This article not only to describes the legal background of quality control, but also how control test results obtained by a Croatian official control laboratory are compared to manufacturer's results. We have found that testing results can slightly differ depending on methods/analytical procedures used in different laboratories. This investigation has also shown how important it is to test finished medicinal products, independently of testing at intermediate stages, and how retesting by control authorities ensures that marketed vaccines meet quality standards. PMID: 21183435 [PubMed - as supplied by publisher] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4386547 Wed, 01 Dec 2010 00:00:00 +0100 4386547 http://www.medworm.com/index.php?rid=4386546&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21183436%26dopt%3DAbstract Authors: Marinković N, Pašalić D, Ferenčak G, Gršković B, Rukavina AS The term dioxins usually refers to polychlorinated dibenzo-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). As 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) has the highest toxic potential, the toxic potentials of other PCDDs and PCDFs are defined in comparison with it. Human exposure to dioxins can be environmental (background), occupational, or accidental pollution. In the human body, dioxins are in part metabolised and eliminated, and the rest is stored in body fat. People vary in their capacity to eliminate TCDD, but it is also dose-dependent; the elimination rate is much faster at higher than lower levels. The liver microsomal P4501A1 enzyme oxygenates lipophilic chemicals such as dioxins. It is en... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4386546 Wed, 01 Dec 2010 00:00:00 +0100 4386546 http://www.medworm.com/index.php?rid=4386545&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21183437%26dopt%3DAbstract Authors: Katić J, Fučić A, Gamulin M Health disorders and diseases related to environmental exposure in children such as cancer and immunologic disturbances (asthma, allergies) are on the rise. However, complex transplacental and prepubertal genotoxicology is given very limited consideration, even though intrauterine development and early childhood may be critical for elucidating the cancer aetiology. The foetus is transplacentally exposed to contaminants in food and environment such as various chemicals, drugs, radiochemically contaminated water and air. Target organs of xenobiotic action may differ between the mother and the foetus due to specific stage of developmental physiology and enzyme distribution. This in turn may lead to different levels of clastogenic and aneugenic metab... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4386545 Wed, 01 Dec 2010 00:00:00 +0100 4386545 http://www.medworm.com/index.php?rid=4386544&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21183438%26dopt%3DAbstract Authors: Slišković A This paper discusses the negative effects of shiftwork which are classified into four categories: biological functions, efficiency, social / family domains and health. It presents systematic review of previous studies which indicated at health problems in shiftworkers which can, at least in part, be attributed to disturbation of circadian rhythms imposed by shift / night work. Health probles which are connected with shiftork are: sleeping problems, gastrointestinal and cardiovascular diseases, carcinoma, problems with reproductive health in women and lower levels of psychological health.The paper also discusses about shiftwork tolerance. The process model of shiftwork and health, made by Smith and his coworkers in 1999, is used as theoretical framework. An accent... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4386544 Wed, 01 Dec 2010 00:00:00 +0100 4386544 http://www.medworm.com/index.php?rid=4289991&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21183439%26dopt%3DAbstract This article speaks about, the work of Božo Metzger and the late Dragutin Mayer, two remarkable radiation scientists from Croatia. Both had a unique role in teaching radiation protection and physics at a university level. Their recollections reveal many unknown details about the history of radiation science and radiation protection in Croatia. PMID: 21183439 [PubMed - as supplied by publisher] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4289991 Wed, 01 Dec 2010 00:00:00 +0100 4289991 http://www.medworm.com/index.php?rid=4023710&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860967%26dopt%3DAbstract This study shows that combined exposure to mixed organic solvents and occupational noise can exacerbate hearing loss in workers. Therefore, an appropriate hearing protection programme is recommended, that would include short-interval audiometric examinations and efficient hearing protectors. PMID: 20860967 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4023710 Tue, 31 Aug 2010 23:00:00 +0100 4023710 http://www.medworm.com/index.php?rid=4023709&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860968%26dopt%3DAbstract Authors: Rostoka E, Isajevs S, Baumane L, Line A, Silina K, Dzintare M, Sharipova J, Svirina D, Kalvinsh I, Sjakste N Natural compounds are known to modify NO content in tissues; however, the biological activity of polyphenol-rich food often does not correspond to the effects of individual polyphenols on NO synthase activity. The aim of this study was to see how natural compounds luteolin, indole-3-carbinol, and lycopene modify NO production in rat tissues and change the expression of the iNOS gene and protein. Indole-3-carbinol produced multiple effects on the NO level; it significantly decreased NO concentration in blood, lungs, and skeletal muscles and increased it in the liver. Indole-3-carbinol enhanced lipopolyssaccharide (LPS)-induced NO production in all rat organs. It decrease... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4023709 Tue, 31 Aug 2010 23:00:00 +0100 4023709 http://www.medworm.com/index.php?rid=4023708&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860969%26dopt%3DAbstract In conclusion, either metal given alone was toxic/genotoxic and caused oxidative stress. On day 4 of combined treatment, the higher copper concentration was more toxic than either metal alone. In contrast, on day 7 of combined treatment, the lower copper concentration showed lower oxidative and DNA damage. These complex interactions can not be explained by simple antagonism and/or synergism. Further studies should go in that direction. PMID: 20860969 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4023708 Tue, 31 Aug 2010 23:00:00 +0100 4023708 http://www.medworm.com/index.php?rid=4023707&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860970%26dopt%3DAbstract Authors: Gjorgieva D, Kadifkova-Panovska T, Baceva K, Stafilov T The aim of this study was to determine and compare Ba, Cr, Cd, Fe, Sr, Pb, and Zn content in medicinal herbs Urtica dioica L., Taraxacum officinale, and Matricaria recutita growing in polluted and unpolluted areas of the Republic of Macedonia. The metal content was determined using inductively coupled plasma atomic emission spectroscopy (ICP-AES). In the unpolluted area of Mt. Plackovica the metal content in Taraxacum officinale was in the descending order: Fe>Sr>Zn>Ba>Cr, while Pb and Cd were below the limit of detection. In the polluted area of Veles, the order was as follows: Fe>Zn>Sr>Pb>Ba>Cd>Cr. Our results suggest that quality assurance and monitoring of toxic metals is needed for plant... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4023707 Tue, 31 Aug 2010 23:00:00 +0100 4023707 http://www.medworm.com/index.php?rid=4023706&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860971%26dopt%3DAbstract Authors: Pizent A, Butković S Copper concentration was estimated in tap water samples obtained from 70 households in Zagreb, serviced by a public water supply system. First-draw and flushed samples of tap water were collected in the morning and total copper concentration was determined by graphite furnace atomic absorption spectrometry with Zeeman-effect background correction. We also estimated the contribution of plumbing material to copper concentrations in tap water. In households with copper pipes, median and range copper values were 310 μg L-1 [(27 to 632) μg L-1] in first-draw samples and 16 μg L-1 [(5 to 52) μg L-1] in flushed samples. Corresponding values for households with galvanised pipes were 140 μg L-1 [(11 to 289) μg L-1] and 8 μg L-1 [(1 to 42) Î... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4023706 Tue, 31 Aug 2010 23:00:00 +0100 4023706 http://www.medworm.com/index.php?rid=4023705&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860972%26dopt%3DAbstract Authors: Martinac AI, Tomić S, Simicić M Variations introduced to medicinal product documentation must not affect the quality, efficacy, and safety of the product. Croatian Medicinal Products Act and accompanying ordinances are largely aligned with the EU regulations. The EU has now tried to simplify the issue of variations with a new Regulation, creating differences in the definition of and approach to resolving certain types of variations between Croatia and the EU. These differences could hinder the approval procedure for variations in Croatia, particularly for medicines already approved in the EU. Amending the Croatian Ordinance on medicines already authorised in the EU would be one way of maintaining the efficiency of the Croatian regulatory system. PMID: 20860972 [PubMe... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4023705 Tue, 31 Aug 2010 23:00:00 +0100 4023705 http://www.medworm.com/index.php?rid=4023704&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860973%26dopt%3DAbstract Authors: Lancić F, Majski-Cesarec S, Musil V By following a child's growth, development, and health, school medicine specialist can see opportunities for career choice. Special attention is needed for schoolchildren with chronic diseases and developmental difficulties, because of limited occupation choices. Studies report 10 % to 15 % prevalence of chronic diseases among schoolchildren. Parents and children should be informed about child's limitations before career choice. It would be helpful for the students to develop interests for occupations that are not contraindicated for their condition. Physical examination gives an insight into the psycho-physical abilities of an eighth-grade primary school student for further education. During examination, counselling and vocational guidan... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4023704 Tue, 31 Aug 2010 23:00:00 +0100 4023704 http://www.medworm.com/index.php?rid=4023703&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860974%26dopt%3DAbstract This article presents a case of a 40-year-old female patient with a right-side middle ear tuberculosis. The patient was a nurse, who had worked at the Department of Pulmology, Clinical Hospital Rijeka for 17 years. The cause was infection with Mycobacterium tuberculosis while she assisted in bronchoscopy. The patient was referred to occupational medicine (OM) for confirmation of occupational disease immediately after surgery. The disease was confirmed as occupational by the Croatian Institute for Health Insurance of Health Protection at Work.During surgery a sample was taken for microbiological analysis. We did initial and control multislice computed tomography (MSCT) and control magnetic resonance imaging (MRI) of temporal bones 6 months after the surgery. The initial MSCT showed total ma... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4023703 Tue, 31 Aug 2010 23:00:00 +0100 4023703 http://www.medworm.com/index.php?rid=4023702&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860975%26dopt%3DAbstract Authors: Kozul D, Romanić SH This review presents the findings on the distribution and levels of 20 congeners of polychlorinated biphenyls (PCBs) and 7 organochlorine pesticides (OCPs) all over the world, based on measurements in samples of air, human milk and pine needles. The Institute for Medical Research and Occupational Health has been conducting research in all three matrices for many years, and this review summarises its results too. Significant decrease in concentrations of organochlorine compounds has been seen after the legal ban of their use, but that decresing trend has been slowed down and they are still found in all samples. In general, higher PCB levels are found in samples from urban locations, pesticides levels are higher in samples from locations where has been the... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4023702 Tue, 31 Aug 2010 23:00:00 +0100 4023702 http://www.medworm.com/index.php?rid=4023701&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860976%26dopt%3DAbstract Authors: Lazarus M Cadmium occurs in the environment naturally and as a pollutant. Its exposure is inevitable and may produce toxic effects in many organs and organ systems through binding to biological structures, accumulation in internal organs or induction of free radical production. Another important aspect of Cd toxicity is its interaction, often anthagonistic, with essential elements. Vice versa, additional intake of the essential elements may have beneficial influence on distribution and toxic effects of cadmium. Selenium is an essential microelement and a constituent of many selenoproteins with antioxidant properties that bind cadmium (and other toxic elements such as mercury or arsenic). This review summarizes results, to date, of cadmium toxicokinetics and toxicodinamics, sel... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4023701 Tue, 31 Aug 2010 23:00:00 +0100 4023701 http://www.medworm.com/index.php?rid=4023700&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20860977%26dopt%3DAbstract Authors: Badel T, Keros J, Krapac L, Pavicin IS Bisphosphonate treatment and its aetiopathogenic association with aseptic osteonecrosis of the jaw is one of the more prominent public health issues today. The aim of this review is to see into the mechanisms of bisphosphonate effects on bones described in literature (anti-osteoclastic activity, cytotoxicity, antiangiogenesis, genetic factors, and imbalance between osteoclasts and osteoblasts). Bisphosphonate treatment is the dominant cause of jaw necrosis. Epidemiological data show an exclusive incidence of osteonecrosis of the jaw in patients who took one or a combination of nitrogen-containing bisphosphonates. Risk factors vary by the bisphosphonate potency (particularly risky are the highly potent pamidronate and zoledronate, which ar... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=4023700 Tue, 31 Aug 2010 23:00:00 +0100 4023700 http://www.medworm.com/index.php?rid=3718760&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587388%26dopt%3DAbstract This study investigates the effects of concomitant administration of selenium, magnesium, and calcium with arsenic on blood biochemistry and oxidative stress. Selenium was the most effective in reducing arsenic-induced inhibition of blood delta-aminolevulinic acid dehydratase (ALAD) activity and liver oxidative stress. Calcium and magnesium also showed favourable effects on haematological and other biochemical parameters. Because selenium was the most effective, it should be added to chelation therapy to achieve the best protective effects against arsenic poisoning in humans. PMID: 20587388 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718760 Mon, 31 May 2010 23:00:00 +0100 3718760 http://www.medworm.com/index.php?rid=3718759&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587389%26dopt%3DAbstract This study points to sawmill settled dust as endotoxin reservoir and suggests that it may add to already high exposure to airborne endotoxins associated with wood processing. Investigations of the relation between settled and airborne endotoxin levels should be continued to better understand the sources and sites of endotoxin contamination in wood-processing industry. PMID: 20587389 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718759 Mon, 31 May 2010 23:00:00 +0100 3718759 http://www.medworm.com/index.php?rid=3718758&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587390%26dopt%3DAbstract This study has shown that Asp f 1 settles on dust at poultry farms and that occupational exposure to this allergen deserves monitoring in livestock buildings. PMID: 20587390 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718758 Mon, 31 May 2010 23:00:00 +0100 3718758 http://www.medworm.com/index.php?rid=3718757&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587391%26dopt%3DAbstract Authors: Sauerborn Klobucar R, Zaja R, Franjević D, Brozović A, Smital T One of the most intriguing defence strategies which aquatic organisms developed through evolution is multixenobiotic resistance (MXR). The key mediators of MXR activity are ATP-binding cassette (ABC) transport proteins. They provide resistance of aquatic organisms by binding xenobiotics and extruding them from cells in an energy-dependent manner. Since Cyprinid fish species are common target in freshwater biomonitoring programs, we have studied the presence of two main MDR/MXR efflux transporters P-glycoprotein (Pgp, Abcb1) and MRP-like protein(s) (Abcc) in the liver of five Cyprinid species: common carp, European chub, sneep, barbel, and silver prussian carp. Their presence was evaluated on the mRNA and pro... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718757 Mon, 31 May 2010 23:00:00 +0100 3718757 http://www.medworm.com/index.php?rid=3718756&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587392%26dopt%3DAbstract Authors: Pourabedian S, Barkhordari A, Habibi E, Rismanchiyan M, Zare M The aim of this study was to investigate the effects of occupational exposure to 1,6-hexamethylene diisocyanate (HDI) on peak flowmetry in automobile body paint shop workers in Iran. We studied a population of 43 car painters exposed to HDI at their workplaces. Peak expiratory flow was tested for one working week, from the start to the end of each shift. Air was sampled and HDI analysed in parallel, according to the OSHA 42 method. Daily and weekly HDI exposure averages were (0.42+/-0.1) mg m(-3) and (0.13+/-0.05) mg m(-3), respectively. On painting days, 72 % of workers showed more than a 10 % variation in peak expiratory flow. Inhalation exposure exceeded the threshold limit value (TLV) ten times over. This stron... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718756 Mon, 31 May 2010 23:00:00 +0100 3718756 http://www.medworm.com/index.php?rid=3718755&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587393%26dopt%3DAbstract In this study, we evaluated the effect of essential oils of cinnamon, lavender, rosemary, and sage at 1 % (v/v) concentration in yeast media inoculated with spores (final concentration 106 mL-1 media) of Aspergillus ochraceus ZMPBF 318 and Penicillium expansum ZMPBF 565, alone or in combination, on fungal biomass. Cinnamon showed the best inhibitory effect (100 %). Lavender oil best inhibited the growth of Aspergillus ochraceus (nearly 100 %), and was less successful with Penicillium expansum (having dropped to 57 % on day 28). With cultivation time the inhibitory effect of sage and rosemary oil grew for Aspergillus ochraceus and dropped for Penicillium expansum.These results suggest that fungi can be controlled with essential oils, especially with cinnamon oil. PMID: 20587393 [PubMed ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718755 Mon, 31 May 2010 23:00:00 +0100 3718755 http://www.medworm.com/index.php?rid=3718754&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587394%26dopt%3DAbstract Authors: Prodanovska-Stojcevska V, Isjanovska R, Popova-Ramova E Healthcare workers are at risk of occupationally-acquired viral infections such as human immunodeficiency virus (HIV), hepatitis B (HBV), and hepatitis C (HCV). HCV is parenterally transmitted and has been found in every part of the world. This cross-sectional study was conducted to establish the awareness and attitude about HCV infections among 210 full-time and part-time nursing students of the Medical College in Bitola, Macedonia from May to June 2009. For this purpose we used a self-administered questionnaire which consisted of three parts. The first included demographic data, the second included questions about causes of infection, mode of transmission, symptoms, acute and chronic hepatitis, and prevention, and the t... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718754 Mon, 31 May 2010 23:00:00 +0100 3718754 http://www.medworm.com/index.php?rid=3718753&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587395%26dopt%3DAbstract This article reports the findings from a GYTS conducted in Montenegro in 2008, which included 5723 adolescents. More than 30 % of students aged 13 to 15 tried smoking, 5.1 % smoked cigarettes, and 3.6 % of students used tobacco products other than cigarettes. Four in 10 ever smokers started to smoke before the age of 10. More than half the students reported secondary smoke exposure at home. Almost all (96.5 %) current smokers bought cigarettes in a store. Two in 10 students owned an artifact with a cigarette or tobacco brand logo on it. The GYTS study has shown that there is an urgent need to introduce effective child-oriented smoking prevention programmes in early elementary school classes. These should be accompanied by public awareness campaigns on smoke-free homes. PMID: 20587395 [... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718753 Mon, 31 May 2010 23:00:00 +0100 3718753 http://www.medworm.com/index.php?rid=3718752&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587396%26dopt%3DAbstract Authors: Skitarelić N, Mazzi A, Skitarelić N, Misulić J, Vuletić A Olive pollen is one of the most common respiratory allergens in the Mediterranean countries. The aim of this study was to establish the frequency of hypersensitivity to the pollen of Olea europea in pollen allergic patients in the County of Zadar. The study included 671 patients with pollen allergy; 61 % were male and 39 % female. 53.5 % were children aged from 4 to 14 years and 46.5 % adolescents and adults from 15 to 59 years. We took their case history, clinically examined them, and tested using the skin prick test and enzymo-immunologic UniCAP test for specific IgE antibodies. For statistical analysis we used the chi-square test. Hypersensitivity to Olea europea pollen was confirmed in 8.8 % patients wit... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718752 Mon, 31 May 2010 23:00:00 +0100 3718752 http://www.medworm.com/index.php?rid=3718751&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587397%26dopt%3DAbstract In this study, MN levels were investigated in cytokinesis-blocked lymphocytes of 200 healthy male and female blood donors selected at random from the general population of Croatia. The aim was to assess the variability and determine possible influences of external and/or internal factors on the background levels of MN and to establish the cut-off value for the CBMN assay. The background frequency of MN was (6.90+/-3.32) MN (median 7 MN) and the range was 0 to 18 MN per 1000 binuclear lymphocytes. The cut-off value, which corresponds to 95th percentile of the distribution of 200 individual values, was 12.5 MN. Spontaneous formation of MN was influenced by sex, age, and smoking. Women had higher MN levels than men. However, only age and smoking significantly increased the values of all param... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718751 Mon, 31 May 2010 23:00:00 +0100 3718751 http://www.medworm.com/index.php?rid=3718750&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587398%26dopt%3DAbstract In this study, we used the average concentrations of naturally occurring radionuclide 226Ra in drinking water at different parts of Iran to estimate the annual effective dose. In the other part of the study, we measured the concentrations of 210Po in Iranian cigarettes to estimate the internal intake of this radionuclide and its concentration in the lung tissues of smokers. The results indicate that the average concentration of 226Ra in Iranian drinking water was below the 100 mBq L(-1) recommended by the World Health Organization while the average concentration of 210Po and 210Pb in Iranian cigarettes was relatively high in comparison with other cigarettes found on the market. PMID: 20587398 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718750 Mon, 31 May 2010 23:00:00 +0100 3718750 http://www.medworm.com/index.php?rid=3718749&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587399%26dopt%3DAbstract This report describes a case of extreme hyperkalaemia caused by drugs in an 82-year-old female patient without severe renal insufficiency, who was successfully treated without haemodialysis. The patient had been treated for arterial hypertension and type 2 diabetes mellitus for 30 years. Over the last years she had been receiving enalapril and metformin. Three weeks before the admission to the hospital, she was receiving a non-steroidal anti-inflammatory drug (NSAID) because of the back pain. She was admitted to hospital due to a collapse and weakness in the limbs. Laboratory tests showed extreme hyperkalaemia, high blood sugar, metabolic acidosis, elevated serum creatinine and blood urea nitrogen (BUN), and a slightly elevated serum sodium. On ECG, we noticed typical signs of hyperkalaemi... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718749 Mon, 31 May 2010 23:00:00 +0100 3718749 http://www.medworm.com/index.php?rid=3718748&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587400%26dopt%3DAbstract Authors: Vucemilović A Weapons of mass destruction (WMD) best portray the twisted use of technological achievements against the human species. Despite arm control efforts, WMD threat continues to exist and even proliferate. This in turn calls for improvement in defensive measures against this threat. The modern soldier is exposed to a number of chemical, biological, and radiological agents in military and peace operations, while civilians are mainly exposed to terrorist attacks. Regardless of origin or mode of action, WMDs and other noxious agents aim for the same - to make an organism dysfunctional. Because their effects are often delayed, these agents are hard to spot on time and treat. This review presents a biomedical aspect of agents used in warfare and terrorism, including pol... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718748 Mon, 31 May 2010 23:00:00 +0100 3718748 http://www.medworm.com/index.php?rid=3718747&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20587401%26dopt%3DAbstract Authors: Milić M Estimation of individual susceptibility to mutagens is often a part of epidemiological studies monitoring the appearance of malignant disease in different populations. Genome exposure to mutagens can lead to DNA damage. The rate of damage depends on individual differences in response, which are usually associated with differences in DNA repair capacity. Cytogenetic studies have shown that the genome of tumour cells is less stable than normal cells and therefore accumulates more damage. Tumour patients show a higher frequency of chromatid and chromosomal aberrations and a predisposition to certain types of tumours. One of the common biomarkers used in monitoring tumour appearance and changed response to DNA damage is the bleomycin test. In its active form, bleomycin ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3718747 Mon, 31 May 2010 23:00:00 +0100 3718747 http://www.medworm.com/index.php?rid=3433335&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20352670%26dopt%3DAbstract Authors: Varnai VM, Macan J, Calusić AL, Sabolić-Pipinić I, Turk R PMID: 20352670 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3433335 Mon, 01 Mar 2010 00:00:00 +0100 3433335 http://www.medworm.com/index.php?rid=3411785&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338862%26dopt%3DAbstract Authors: Kašuba V, Rozgaj R, Gamulin M, Trošić I Irinotecan is a topoisomerase I interactive agent, widely used in the treatment of metastatic colorectal cancer. The genotoxic effects of the maximum single dose (18 mug mL-1), recommended monotherapy dose (9 mug mL-1), and recommended combined therapy dose (4.5 mug mL-1) of irinotecan were studied on V79 cells using the comet assay, chromosome aberration assay, and micronucleus test. The cells were treated with irinotecan for 2 h or 24 h. The statistical significance of the results was determined using the one-way ANOVA test and a nonparametric Mann Whitney U test. The comet assay did not show dose-dependent or time-dependent effects. The chromosome aberration analysis showed large DNA rearrangements, i.e., chromosome ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411785 Mon, 01 Mar 2010 00:00:00 +0100 3411785 http://www.medworm.com/index.php?rid=3411784&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338863%26dopt%3DAbstract In conclusion, melatonin was found to be protective against lipid peroxidation induced by benzene. PMID: 20338863 [PubMed - as supplied by publisher] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411784 Mon, 01 Mar 2010 00:00:00 +0100 3411784 http://www.medworm.com/index.php?rid=3411783&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338864%26dopt%3DAbstract Authors: Dikić D, Sajli L, Benković V, Knežević AH, Brozović G, Lisičić D, Mojsović A, Oršolić N Prometryne is a methylthio-s-triazine herbicide. Significant trace amounts are found in the environment, mainly in water, soil, and food plants. The aim of this study was to establish brain and blood prometryne levels after single oral dose (1 g kg-1) in adult male and female mice. Prometryne was measured using the GC/MS assay at 1, 2, 4, 8, and 24 h after prometryne administration. Peak brain and blood prometryne values were observed 1 h after administration and they decreased in a time-dependent manner. Male mice had consistently higher brain and blood prometryne levels than female mice. The observed prometryne kinetics was simil... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411783 Mon, 01 Mar 2010 00:00:00 +0100 3411783 http://www.medworm.com/index.php?rid=3411782&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338865%26dopt%3DAbstract In this study, we used the comet assay and micronucleus test to assess DNA damage in the erythrocytes of the European sea bass (Dicentrarchus labrax) exposed to environmental pollution in situ. Fish were collected from a fish farm in the Trogir Bay and their cages placed at an unpolluted reference site Solta (Necujam Bay) and a polluted site Vranjic (Kastela Bay) for four weeks. A group of fish which remained at the fish farm Trogir Bay were used as the second control group. Fish exposed at the Vranjic site showed a significantly higher erythrocyte DNA damage, measured by the comet assay, than either control group. Micronucleus induction showed a similar gradient of DNA damage, but did not reach statistical significance. Our results show that cage exposure of a marine fish D. labrax can be... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411782 Mon, 01 Mar 2010 00:00:00 +0100 3411782 http://www.medworm.com/index.php?rid=3411781&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338866%26dopt%3DAbstract This article brings the results of dustfall measurements from 1975 to 2008. Dustfall was low in the city, the nearby islands, and Gorski Kotar. Recommended and limit values were occasionally exceeded in the Bakar Bay due to emissions from the coke plant and harbour at Site 2 (1979-1997) and from the shipyard at Site 3. Lead content in the dustfall was below the national limits, save for two occasions at Site 2. Deposition of sulphur and nitrogen at the inland sites were below the respective critical load values. PMID: 20338866 [PubMed - as supplied by publisher] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411781 Mon, 01 Mar 2010 00:00:00 +0100 3411781 http://www.medworm.com/index.php?rid=3411780&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338867%26dopt%3DAbstract Authors: Vudrag M, Rihtar TK, Vegnuti M The aim of this study was to assess malignant mesothelioma morbidity due to exposure to asbestos in a population living in districts Nova Gorica and Tolmin (49,850 people) near the asbestos manufacturing village Anhovo (Slovenia) and to compare it with the entire Slovene population (1,949,750 people). Crude rates per 100,000 people were calculated from the total number of mesotheliomas, and risk assessment in the studied vs. total population was based on 23 years worth of data. Time series data on mesothelioma cases were also processed as a forecast of new cases by 2010.The crude incidence of mesothelioma per 100,000 individuals for all of Slovenia was 21.4, while for the Nova Gorica district including the village Anhovo it is 170.2 and for the T... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411780 Mon, 01 Mar 2010 00:00:00 +0100 3411780 http://www.medworm.com/index.php?rid=3411779&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338868%26dopt%3DAbstract This study showed the presence of solid impurities, particularly of a neurotoxic compound of Al3+ in the final products. FPIA identified the aminoethane group close to the substituted benzene ring, but did not detect the two major precursors of MDMA: MDNP and piperonal. Raman spectroscopy is an attractive alternative technique to characterise ecstasy pills and it can identify stereoisomeric forms such as cis-MDNP and trans-MDNP, which exhibit signals at 1650 cm-1 and 1300 cm-1, respectively. PMID: 20338868 [PubMed - as supplied by publisher] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411779 Mon, 01 Mar 2010 00:00:00 +0100 3411779 http://www.medworm.com/index.php?rid=3411778&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338869%26dopt%3DAbstract In this study, we developed a qualitative GC-MS method to measure elimination of TCP and TAMORF through rat urine in order to learn more about the mechanisms through which TCP protects an organism from OP poisoning and to determine the duration of this protective effect. GC-MS showed that six hours after treatment with TCP, rat urine contained only its metabolite 1-thienylcyclohexene, while urine of rats treated with TAMORF contained both TAMORF and its metabolites. PMID: 20338869 [PubMed - as supplied by publisher] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411778 Mon, 01 Mar 2010 00:00:00 +0100 3411778 http://www.medworm.com/index.php?rid=3411777&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338870%26dopt%3DAbstract Authors: Tomić S, Milčić N, Sokolić M, Martinac AI The appearance of counterfeit medicines in supply chains is a global public health problem that may seriously affect patients. Counterfeit drugs do not meet quality standards and do not declare their real composition and/or source for the purposes of fraud. They may be generic or innovative, they may contain genuine constituents in a fake packaging, or wrong ingredients, or inactive ingredients, or an incorrect quantity of the active substance. In Croatia, no cases of counterfeit medicines have been detected so far, but the Agency for Medicinal Products and Medical Devices has received 34 samples of medicines and other products for testing from Zagreb City Police. The samples included medicines for erectile dysf... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411777 Mon, 01 Mar 2010 00:00:00 +0100 3411777 http://www.medworm.com/index.php?rid=3411776&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338871%26dopt%3DAbstract Authors: Acharya S, Sanjeev G, Bhat NN, Narayana Y The micronucleus assay in human peripheral blood lymphocytes is a sensitive indicator of radiation damage and could serve as a biological dosimeter in evaluating suspected overexposure to ionising radiation. Micronucleus (MN) frequency as a measure of chromosomal damage has also extensively been employed to quantify the effects of radiation dose rate on biological systems. Here we studied the effects of 8 MeV pulsed electron beam emitted by Microtron electron accelerator on MN induction at dose rates between 35 Gy min-1 and 352.5 Gy min-1. These dose rates were achieved by varying the pulse repetition rate (PRR). Fricke dosimeter was employed to measure the absorbed dose at different PRR and to ensure uniform dose distribution of the e... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411776 Mon, 01 Mar 2010 00:00:00 +0100 3411776 http://www.medworm.com/index.php?rid=3411775&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338872%26dopt%3DAbstract Authors: Kanceljak-Macan B Allergotoxicology studies the influence of pollutants on the development of allergic reactions and diseases. At the beginning, the research was focused on outdoor air pollutants, while recently it turns to the indoor environment, mainly because people this is where people spend most of their time. Air pollutants may be solid, soluble, or gaseous particles in nature, and they can differ in size, structure, and sources. Pollutants can be of biological or nonbiological origin. Currently interesting air pollutants include particulate matter, ozone, nitrogen oxides, and bioaerosols. The mechanisms of pollutant activity depend on the particle size, solubility, site of deposition, and specific chemical properties. Recent studies have shown that different pollutants ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411775 Mon, 01 Mar 2010 00:00:00 +0100 3411775 http://www.medworm.com/index.php?rid=3411774&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338873%26dopt%3DAbstract Authors: Ivanković T, Hrenović J Surfactants are a diverse group of chemicals that are best known for their wide use in detergents and other cleaning products. After use, residual surfactants are discharged into sewage systems or directly into surface waters, and most of them end up dispersed in different environmental compartments such as soil, water or sediment. The toxic effects of surfactants on various aquatic organisms are well known. In general, surfactants are present in the environment at levels below toxicity and in Croatia below the national limit. Most surfactants are readily biodegradable and their amount is greatly reduced with secondary treatment in wastewater treatment plants. The highest concern is the release of untreated wastewater or wastewater that has ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411774 Mon, 01 Mar 2010 00:00:00 +0100 3411774 http://www.medworm.com/index.php?rid=3411773&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338874%26dopt%3DAbstract Authors: Cvjetko P, Cvjetko I, Pavlica M Thallium is a naturally occurring trace element, widely distributed in the earth's crust, but at very low concentrations. It does not have a known biological use and does not appear to be an essential element for life. It has been considered one of the most toxic heavy metals.Occasionally, there are reports on thallium poisoning as results of suicide or murder attempt or accident. The main threat to humans is through occupational exposure, environmental contamination, and accumulation in food, mainly in vegetables grown on contaminated soil. Increasing use in emerging new technologies and demanding high-tech industry constantly raise concern about exposure risk to all living organisms. Thallium is considered a cumulative poison that can cause ad... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411773 Mon, 01 Mar 2010 00:00:00 +0100 3411773 http://www.medworm.com/index.php?rid=3411772&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20338875%26dopt%3DAbstract This article brings an overview of the mechanisms of action of antineoplastic drugs used in the clinical setting. It also describes the genotoxic potentials of the most important classes of antineoplastic drugs involved in standard chemotherapy protocols. Classification of antineoplastic drugs according to the IARC monographs on the evaluation of carcinogenic risks to humans is accompanied by data on their mutagenicity and the most recent updates in the Anatomical Therapeutic Chemical (ATC) Classification System. We report the main findings of biomonitoring studies that were conducted in exposed healthcare workers all over the world between 1980 and 2009 using four biomarkers: sister chromatid exchanges, chromosome aberrations, micronuclei. and the comet assay. The methods are briefly expl... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3411772 Mon, 01 Mar 2010 00:00:00 +0100 3411772 http://www.medworm.com/index.php?rid=3160492&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061238%26dopt%3DAbstract In this study, the concentration of OTA and sphinganine/sphingosine (Sa/So) ratio, the biomarker of another nephrotoxic mycotoxin fumonisin B1 exposure, were analysed in 45 human urine samples collected in the endemic village of Kaniza in Croatia and in 18 samples from control village. Samples were collected twice from the same persons in 2000 and 2005. In both years the frequency of OTA-positive samples was higher in Kaniza (43 % and 18 %, respectively) than in the control village (28 % and 6 %, respectively). OTA concentrations in samples collected in Kaniza were higher in 2000 than in 2005 (p<0.005). Although in both years Sa/So ratio was higher in Kaniza, the difference from the control group was not statistically significant. No control sample contained OTA and had the Sa/So ratio ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160492 Tue, 01 Dec 2009 00:00:00 +0100 3160492 http://www.medworm.com/index.php?rid=3160491&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061239%26dopt%3DAbstract Authors: Matković K, Vucemilo M, Vinković B The air of animal dwellings can contain great amounts of bioaerosol composed of dust, bacteria, fungi, and endotoxins. The composition may depend on animal species, building construction, animal accommodation, and microclimate parameters, to name just a few factors. Pathogens contained may be a serious threat to animal and human health.The aim of our study was to analyse the fungi aerosol content in a stable housing dairy cows and in a coop for laying hens over the three autumn months of 2007. The air was sampled on Petri dishes with Sabouraud glucose agar. After laboratory treatment, we identified the most common fungi. Their count in the stable ranged from 3.98 x 103 CFU m-3 to 5.11 x 104 CFU m-3 and in the coop from 6.89 x 104 ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160491 Tue, 01 Dec 2009 00:00:00 +0100 3160491 http://www.medworm.com/index.php?rid=3160490&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061240%26dopt%3DAbstract Authors: Piecková E, Hurbánková M, Cerná S, Lisková A, Kováciková Z, Kolláriková Z, Wimmerová S Mould Stachybotrys chartarum (Ehrenb.) Hughes is known to pose a health risk in indoor environments. Most of its strains can produce several intra- and extracellular trichothecene mycotoxins. Complex secondary metabolites of stachybotrys isolates from mouldy dwellings/public buildings in Slovakia were intratracheally instilled in Wistar male rats (4 microg in 0.2 mL of 0.2 % dimethylsulphoxide; diacetoxyscirpenol as the positive control). After three days, haematological parameters were measured in peripheral blood and inflammatory response biomarkers in bronchoalveolar lavage fluid (BALF), and the results were statistically analysed. Exometa... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160490 Tue, 01 Dec 2009 00:00:00 +0100 3160490 http://www.medworm.com/index.php?rid=3160489&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061241%26dopt%3DAbstract In this study, we investigated the effects of patulin on the thymus of growing male rats aged five to six weeks. The rats were receiving it orally at a dose of 0.1 mg kg-1 bw a day for either 60 or 90 days. At the end of the experiment, the thymus was examined for histopathology by light microscopy and for epidermal growth factor (EGF) and its receptor (EGFR) by immunolocalisation. For morphometry we used the Bs200prop program to analyse images obtained with the Olympus BX51 light microscope. Cell ultrastructure was studied by electron microscopy. In rats treated with patulin, the thymus showed haemorrhage, plasma cell hyperplasia, a dilation and fibrosis in the cortex, enlarged interstitial tissue between the thymic lobules, enlarged fat tissue, thinning of the cortex, and blurring of the... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160489 Tue, 01 Dec 2009 00:00:00 +0100 3160489 http://www.medworm.com/index.php?rid=3160488&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061242%26dopt%3DAbstract Authors: Kovacić S, Pepeljnjak S, Petrinec Z, Klarić MS For years scientists have suspected that the environment plays a role in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Mycotoxin fumonisin B1 (FB1) is produced by several Fusarium species, mainly by Fusarium verticilioides, which is one of the most common fungi associated with corn worldwide. Fumonisins are known to cause equine leukoencephalomalacia, a disease associated with the consumption of corn-based feeds contaminated with FB1. Here we have reported chronic experimental toxicosis in one-year-old carp (Cyprinus carpio L.) receiving feed containing 100 mg kg-1 or 10 mg kg-1 of added FB1 for 42 days. We focused on fumonisin toxicity in the fish brain. After sta... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160488 Tue, 01 Dec 2009 00:00:00 +0100 3160488 http://www.medworm.com/index.php?rid=3160487&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061243%26dopt%3DAbstract Authors: Klarić MS, Cvetnić Z, Pepeljnjak S, Kosalec I Aspergillus, Penicillium, and Fusarium species frequently contaminate crops. For this reason mycotoxins such as aflatoxins (AFs), ochratoxin A (OTA), fumonisins (FBs), and zearalenone (ZEA) are found in food and feed in a wide range of concentrations, depending on environmental and storage conditions. Consumption of mycotoxin-contaminated food and feed has been associated with acute and chronic poisoning and carcinoma. The aim of this study was to determine the incidence and co-occurrence of AFs (B1+B2+G1+G2), OTA, FBs (B1+B2+B3), and ZEA in 37 samples of cereals and feed randomly collected in 2007 from households of an endemic nephropathy (EN) area in Croatia. The mycotoxins were determined using the competitive direct... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160487 Tue, 01 Dec 2009 00:00:00 +0100 3160487 http://www.medworm.com/index.php?rid=3160486&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061244%26dopt%3DAbstract Authors: Ivić D, Domijan AM, Peraica M, Milicević T, Cvjetković B From 2002 to 2008, 203 samples of wheat, maize, soybean, and pea were analysed for the presence of Fusarium species. Contamination with Fusarium spp., expressed as the percentage of seeds with Fusarium colonies, ranged from 5 % to 69 % for wheat, from 25 % to 100 % for maize, from 4 % to 17 % for soybean, and from 3 % to 17 % for pea. 187 isolates were collected and the following 19 species determined: F. graminearum, F. poae, F. avenaceum, F. verticillioides, F. sporotrichioides, F. heterosporum, F. crookwellense, F. tricinctum, F. semitectum, F. oxysporum, F. proliferatum, F. solani, F. equiseti, F. pseudograminearum, F. chlamydosporum, F. sambucinum, F. compactum, F. scirpi, and F. culmorum. Dominant... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160486 Tue, 01 Dec 2009 00:00:00 +0100 3160486 http://www.medworm.com/index.php?rid=3160485&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061245%26dopt%3DAbstract Authors: Uhitil S, Hadina S, Granić K, Jaksić S Fruit juices are popular soft drinks with an important role in human nutrition. Fruit juices are often infested by yeast species that can survive different storage conditions. The aim of this study was to determine the degree of yeast contamination of freshly squeezed juices in three large supermarkets in Zagreb, Croatia. The analysis included 84 juice samples obtained from freshly squeezed orange, lemon, grapefruit, and apples. Their acidity varied between pH 2.1 and pH 4.9. Juice samples were plated directly on Sabouraud 4 % glucose Agar (Merck, 1.05438) and processed according to standardised methods (HRN ISO 7954:2002). Yeasts were isolated in all 84 samples and ranged between 0.005 x 103 and 23 x 103 colony forming units ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160485 Tue, 01 Dec 2009 00:00:00 +0100 3160485 http://www.medworm.com/index.php?rid=3160484&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061246%26dopt%3DAbstract Authors: Rumora L, Grubisić TZ Ochratoxin A (OTA) is a ubiquitous mycotoxin with potential nephrotoxic, carcinogenic, and cytotoxic action. It has been proposed that OTA might be involved in the development of Balkan endemic nephropathy, which is associated with an increased risk of urinary tract tumours, and of other forms of interstitial nephritis. Cell susceptibility to OTA mainly depends on mycotoxin concentrations, duration of exposure, and intracellular molecular and genetic context. OTA can affect a cell by stimulating or inhibiting certain signalling pathways such as mitogen-activated protein kinase (MAPK). Three major mammalian MAPKs have been described: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK. All MAPKs regulate d... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160484 Tue, 01 Dec 2009 00:00:00 +0100 3160484 http://www.medworm.com/index.php?rid=3160483&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061247%26dopt%3DAbstract Authors: Flajs D, Peraica M Citrinin (CTN) is a nephrotoxic mycotoxin produced by several fungal strains belonging to the genera Penicillium, Aspergillus, and Monascus. It contaminates various commodities of plant origin, cereals in particular, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A (OTA). These two mycotoxins are believed to be involved in the aetiology of endemic nephropathy. In addition to nephrotoxicity, CTN is also embryocidal and fetotoxic. The genotoxic properties of CTN have been demonstrated with the micronuleus test (MN), but not with single-cell gel electrophoresis. The mechanism of CTN toxicity is not fully understood, especially not whether CTN toxicity and genotoxicity are the consequence of oxidative stress or of increased permeabi... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160483 Tue, 01 Dec 2009 00:00:00 +0100 3160483 http://www.medworm.com/index.php?rid=3160482&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061248%26dopt%3DAbstract Authors: Pfohl-Leszkowicz A This review addresses the unresolved aetiology of several nephropathies and associated upper tract tumours diagnosed all over the world, but especially in the Balkan regions. Studies conducted over the last 35 years point to mycotoxins, mainly ochratoxin A (OTA) as the main culprit. Recent theories however have implicated aristolochic acids (AA). The aim of this review is to put forward arguments in favour of the mycotoxin theory and to show the incoherence of the AA theory. It discusses the differences between the epidemiology of Balkan endemic nephropathy (BEN) and aristolochic acid nephropathy (AAN); OTA and AA carcinogenicity; clinical and pathological effects induced by OTA and AA; sources of OTA contamination (food, air, drinking water); OTA- and AA-DN... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160482 Tue, 01 Dec 2009 00:00:00 +0100 3160482 http://www.medworm.com/index.php?rid=3160481&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061249%26dopt%3DAbstract Authors: Kosalec I, Cvek J, Tomić S Medicinal plants have a long history of use in therapy throughout the world and still make an important part of traditional medicine. Thus, medicinal plants and herbal products must be safe for the patient (consumer). This review addresses biological contaminants (microbes and other organisms) and chemical contaminants (mycotoxins, toxic elements such as heavy metals, and pesticide residues) as major common contaminants of medicinal herbs and herbal products. To prevent and screen for contamination and ensure safety and conformity to quality standards, medicinal herbs and herbal products should be included in appropriate regulatory framework. PMID: 20061249 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160481 Tue, 01 Dec 2009 00:00:00 +0100 3160481 http://www.medworm.com/index.php?rid=3160480&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061250%26dopt%3DAbstract Authors: Zigman D, Krajina S, Krznarić M This paper describes real-time locating technology and its possible use in health care. Real time locating may be applied in different segments of everyday life, including hospitals (medical equipment and devices, locating patients, and alarm in case of emergency), working environment (locating persons to control access to restricted areas or in case of fire to see if anyone has been trapped inside the building), sports, logistics, retail trade, and offices. Tagged hospital equipment is easy to trace inside hospital premises and the system makes it possible to track patients and staff, and to redistribute work in particular wards. PMID: 20061250 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160480 Tue, 01 Dec 2009 00:00:00 +0100 3160480 http://www.medworm.com/index.php?rid=3160479&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20061251%26dopt%3DAbstract Authors: Wiwanitkit V PMID: 20061251 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=3160479 Tue, 01 Dec 2009 00:00:00 +0100 3160479 http://www.medworm.com/index.php?rid=2852813&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789157%26dopt%3DAbstract Authors: Orescanin V, Nad K, Bartolincić A, Valković V Granulometric, chemical, and leaching properties of sediments dredged in the Plomin Bay (Northern Adriatic Sea, Croatia) were investigated in order to asses the risk of remobilisation of heavy metals into the water column. In total 65 samples from 65 sampling sites were taken from different sediment depths within the bay. Analysis of variance confirmed the homogeneity of granulometric and elemental composition of the investigated sediment throughout its volume. Granulometric analysis showed that all samples corresponded to a pelitic fraction (<0.063 mm). Bulk elemental mass fractions in the sediments were similar to literature data on relatively unpolluted areas of the Adriatic Sea. High sedimentation rate caused by ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852813 Mon, 31 Aug 2009 23:00:00 +0100 2852813 http://www.medworm.com/index.php?rid=2852812&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789158%26dopt%3DAbstract This study demonstrated significant pollution of Boumoussa valley groundwater and of the local wells. Sampled water induced a clear increase in the frequency of micronucleated cells and a lower cell proliferation in human peripheral blood lymphocytes in vitro. PMID: 19789158 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852812 Mon, 31 Aug 2009 23:00:00 +0100 2852812 http://www.medworm.com/index.php?rid=2852811&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789159%26dopt%3DAbstract This study compared the effects of toxicity of ethanol and its first metabolite acetaldehyde in rat astrocytes through cell viability and cell proliferation. The cells were treated with different concentrations of ethanol in the presence or absence of a catalase inhibitor 2-amino-1,2,4 triazole (AMT) or with different concentrations of acetaldehyde. Cell viability was assessed using the trypan blue test. Cell proliferation was assessed after 24 hours and after seven days of exposure to either ethanol or acetaldehyde.We showed that both ethanol and acetaldehyde decreased cell viability in a dose-dependent manner. In proliferation studies, after seven days of exposure to either ethanol or acetaldehyde, we observed a significant dose-dependent decrease in cell number. The protein content stud... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852811 Mon, 31 Aug 2009 23:00:00 +0100 2852811 http://www.medworm.com/index.php?rid=2852810&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789160%26dopt%3DAbstract Authors: Karahalil B, Gumus T, Emerce E, Izdes S, Kanbak O, Kesimci E Ischaemia-reperfusion (I/R) injury is responsible for a number of conditions such as coronary bypass and myocardial infarction, and deaths. Oxygen-free radicals formed during I/R have been proposed as the leading causes of tissue injury, and they play an important role in I/R injury. I/R induces oxidative DNA damage (such as purinic and pyrimidinic base lesions). Comet assay is a suitable and sensitive method for early detection of low-level DNA damage. We used modified alkaline comet assay in peripheral blood lymphocytes and evaluated I/R-induced DNA damage in patients undergoing coronary artery bypass graft (CABG) operation (in vivo model for I/R). No statistically significant difference in DNA damage levels was fo... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852810 Mon, 31 Aug 2009 23:00:00 +0100 2852810 http://www.medworm.com/index.php?rid=2852809&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789161%26dopt%3DAbstract This study investigated possible growth-inhibiting effects of bee venom applied alone or in combination with a cytotoxic drug bleomycin on HeLa and V79 cells in vitro based on clone formation, cell counting, and apoptosis. Melittin, the key component of bee venom, is a potent inhibitor of calmodulin activity, and also a potent inhibitor cell growth and clonogenicity. Intracellular accumulation of melittin correlates with the cytotoxicity of antitumour agents. Previous studies indicated that some calcium antagonists and calmodulin inhibitors enhanced intracellular levels of antitumor agents by inhibiting their outward transport. In this study, treatment of exponentially growing HeLa and V79 cells with bleomycin caused a dose-dependent decrease in cell survival due to DNA damage. This lethal... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852809 Mon, 31 Aug 2009 23:00:00 +0100 2852809 http://www.medworm.com/index.php?rid=2852808&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789162%26dopt%3DAbstract This study provides evidence of adverse respiratory effects in office cleaning women associated with passive smoking in the workplace. Our findings support a stricter implementation of the current national law to protect respiratory health of all workers. PMID: 19789162 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852808 Mon, 31 Aug 2009 23:00:00 +0100 2852808 http://www.medworm.com/index.php?rid=2852807&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789163%26dopt%3DAbstract Authors: Stosić L, Belojević G, Milutinović S Urban noise is an important environmental stressor, and sleep disturbance is its major health effect. Substantial inter-individual variance in these effects might partly be explained by different sensitivity to noise. The aim of this study was to assess the effects of urban noise on sleep and the relation between self-estimated sensitivity to noise and sleep disturbance. A cross-sectional questionnaire survey was performed on 911 adult residents of Nis, Serbia, of whom 388 were men (42.6 %) and 523 women (57.4 %). The streets were regarded as noisy if night equivalent noise level (Leq) was higher than 45 dB(A) and quiet if night Leq was < or =45 dB(A). Noise sensitivity was measured with the Weinstein's Noise Sensitivit... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852807 Mon, 31 Aug 2009 23:00:00 +0100 2852807 http://www.medworm.com/index.php?rid=2852806&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789164%26dopt%3DAbstract Authors: Doko-Jelinić J, Lukić J, Udovicić R, Zuskin E, Nola IA, Zajec Z The aim of this study was to assess to which extent modernisation of an aluminium production complex reduced occupational noise hazard for jobs with the highest potential of exposure. Periodical measurements of noise level were taken at the same workplaces using the same method, before and after modernisation of all plants. The results were compared with the recommended standard. After modernisation, the noise was significantly reduced in all sections of all plants. The greatest reduction was measured in the foundry. After modernisation, the portion of workplaces with excessive noise level dropped significantly (chisquare=21.315; p<0.0001) from 78.4% to 13%. Noise remained a problem in ingot c... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852806 Mon, 31 Aug 2009 23:00:00 +0100 2852806 http://www.medworm.com/index.php?rid=2852805&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789165%26dopt%3DAbstract This study has shown that environmental noise is a significant hazard in urban environments, and assessment of annoyance may prove a useful tool for town planners and public health policy makers. PMID: 19789165 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852805 Mon, 31 Aug 2009 23:00:00 +0100 2852805 http://www.medworm.com/index.php?rid=2852804&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789166%26dopt%3DAbstract This article presents a rare case of acute toxic hepatitis in thirty-one-year old primigravida. In the 36th week of gestation, the patient was introduced nitrofurantoin 100 mg a day due to symptoms of dysuria and enterococcus isolated from urine culture. After induced delivery at term because of hypertension, repeated laboratory findings showed increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and negative hepatitis C and B markers. The patient was subicteric at the time. Coagulation and complete blood count values were within the normal range. Nitrofurantoin therapy was discontinued. Abdominal ultrasound was normal with the exception of a slight hepatomegaly without any lesions, focal or diffuse. Given that discontinuation of nitrofurantoin and introduction of ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852804 Mon, 31 Aug 2009 23:00:00 +0100 2852804 http://www.medworm.com/index.php?rid=2852803&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789167%26dopt%3DAbstract Authors: Simić N, Gregov L This paper discusses the organisational and activational effects of sex hormones, and their influence on cognitive functioning. Previous studies have shown gender differences in specific cognitive abilities. Women generally show an advantage in verbal fluency, perceptual speed and accuracy, as well as in fine motor skills, while men generally show an advantage in spatial and mathematical abilities. These differences in cognitive functioning are thought to occur as a result of foetal brain exposure to different levels of sex hormones during prenatal life. Additional evidence of organisational effects of sex hormones on cognitive functioning also comes from studies of subjects with genetic disorders, such as androgen insensitivity syndrome, congenital adr... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852803 Mon, 31 Aug 2009 23:00:00 +0100 2852803 http://www.medworm.com/index.php?rid=2852802&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19789168%26dopt%3DAbstract This article mentions a few individuals who outlived 100 years in the world, Croatia, and neighbouring countries. Although some argue that the limits of human life cannot be extended over the age of 120 years, for now we cannot predict the actual limits of human life. PMID: 19789168 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2852802 Mon, 31 Aug 2009 23:00:00 +0100 2852802 http://www.medworm.com/index.php?rid=2591905&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19588596%26dopt%3DAbstract Authors: Varnai VM, Ljubicić Calusić A, Sabolić-Pipinić I, Macan J, Turk R PMID: 19588596 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2591905 Sun, 31 May 2009 23:00:00 +0100 2591905 http://www.medworm.com/index.php?rid=2591904&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19588598%26dopt%3DAbstract Authors: Piasek M PMID: 19588598 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2591904 Sun, 31 May 2009 23:00:00 +0100 2591904 http://www.medworm.com/index.php?rid=2585011&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581205%26dopt%3DAbstract Authors: Benković V, Knezević AH, Dikić D, Lisicić D, Orsolić N, Basić I, Kopjar N The aim of this study was to assess radioprotective effects of quercetin and the ethanolic extract of propolis (EEP) in CBA mice exposed to a single radiation dose 4 Gy (60Co). The mice were treated with 100 mg kg-1 quercetin or EEP a day for three consecutive days either before (pre-treatment) or after gamma-irradiation (therapy). Leukocyte count was determined in blood drawn from the tail vein, and DNA damage in leukocytes was assessed using the alkaline comet assay. Genotoxic effects of the test compounds were also evaluated in non-irradiated mice. The levels of radioprotection provided by both test compounds were compared with those established in mice that were gi... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585011 Sun, 31 May 2009 23:00:00 +0100 2585011 http://www.medworm.com/index.php?rid=2585010&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581206%26dopt%3DAbstract Authors: Vitcheva V, Kondeva-Burdina M, Mitcheva M The aim of this study was to trace D-amphetamine toxicity in isolated rat hepatocytes and to elucidate a possible involvement of CYP3A in the mechanisms of its toxicity. To this end, male Wistar rats were treated with nifedipine (5 mg kg(-1) i.p., 5 days), a substrate and inducer of CYP3A. Hepatocytes isolated from nifedipine-treated and control rats were incubated with D-amphetamine at a concentration of 100 micromol L(-1), which was determined to be an average toxic concentration (TC50) for the compound. To evaluate the possible toxic effects of D-amphetamine on freshly isolated rat hepatocytes, we assessed the following parameters: cell viability, lactate dehydrogenase (LDH) activity, and glutathione (GSH).The results showed that ni... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585010 Sun, 31 May 2009 23:00:00 +0100 2585010 http://www.medworm.com/index.php?rid=2585009&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581207%26dopt%3DAbstract Authors: Bagdoniene L, Labeikyte D, Kalviņs I, Borutinskaite V, Prokofjevs A, Trapencieris P, Juodka B, Sjakste N Although described some time ago, gamma-butyrobetaine esters and related compounds have not gained much attention from researchers, and their physiological function remains obscure. Formerly we detected GBB-esterase enzymatic activity in rat blood serum using phenylated gamma-butyrobetaine as an artificial substrate of the enzyme and HPLC. The aim of the present work was to develop an assay that would enable spectrophotometric or colorimetric determination of the reaction products of GBB-esterase activity and to reveal individual proteins performing GBB-esterase activity in rat blood serum. For this purpose gamma-butyrobetaine 1-naphthyl ester was synthesised. Hydroly... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585009 Sun, 31 May 2009 23:00:00 +0100 2585009 http://www.medworm.com/index.php?rid=2585008&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581208%26dopt%3DAbstract This study was designed to compare the effects of calcium channel blockers, alpha-adrenergic, beta-adrenergic, and muscarinic receptor blockers, and of free radical scavengers on insulin secretion from diazinon-treated islets of Langerhans isolated from the pancreas of rats using standard collagenase digestion, separation by centrifugation, and hand-picking technique. The islets were then cultured in an incubator at 37 degrees C and 5 % CO2. In each experimental set 1 mL of 8 mmol L(-1) glucose plus 125 microg mL(-1) or 625 microg mL(-1) of diazinon were added, except for the control group, which received 8 mmol L(-1) glucose alone. The cultures were then treated with one of the following: 30 micromol L(-1) atropine, 100 micromol L(-1) ACh + 10 micromol L(-1) neostigmine, 0.1 micromol L(-1... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585008 Sun, 31 May 2009 23:00:00 +0100 2585008 http://www.medworm.com/index.php?rid=2585007&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581209%26dopt%3DAbstract In conclusion, biological effects observed after administration of Echinacea purpurea preparation suggest that it may be beneficial for the prevention of adverse health effects in workers exposed to ionising radiation. PMID: 19581209 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585007 Sun, 31 May 2009 23:00:00 +0100 2585007 http://www.medworm.com/index.php?rid=2585006&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581210%26dopt%3DAbstract Authors: Vucemilović A, Hadzija M, Jukić I Our Institute's nuclear, biological, and chemical defense research team continuously investigates and develops preparations for skin decontamination against nerve agents. In this in vivo study, we evaluated skin decontamination efficacy against sarin by a synthetic preparation called Mineral Cationic Carrier (MCC) with known ion exchange, absorption efficacy and bioactive potential. Mice were treated with increasing doses of sarin applied on their skin, and MCC was administered immediately after contamination. The results showed that decontamination with MCC could achieve therapeutic efficacy corresponding to 3 x LD(50) of percutaneous sarin and call for further research. PMID: 19581210 [PubMed - in process] (Source: Arhiv za H... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585006 Sun, 31 May 2009 23:00:00 +0100 2585006 http://www.medworm.com/index.php?rid=2585005&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581211%26dopt%3DAbstract Authors: Amahdar L, Anouar A, Ababou B, Verschaeve L, Hilali A With the increasing use of landfill sites, leachates produced by uncontrolled waste disposal have became a serious threat for the aquatic environment. The aim of this study was to evaluate the genotoxicity of leachate and of well water sampled close to the town of Settat in Morocco using the micronucleus test and proliferation kinetics of human peripheral blood lymphocytes in vitro. We also analysed a number of physical and chemical parameters, including pH, % O2, chemical oxygen demand (COD), HCO3(-), Ca2+, Mg2+, Cl(-), and conductivity. The analysis showed much higher levels of nearly all parameters than the Moroccan standard. Increased micronucleus frequencies were also found for both leachate and well water. Preliminary... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585005 Sun, 31 May 2009 23:00:00 +0100 2585005 http://www.medworm.com/index.php?rid=2585004&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581212%26dopt%3DAbstract Authors: Aminian O, Sharifian SA, Mehrdad R, Haghighi KS, Mazaheri M A lot of workers in industries such as foundry, stonecutting, and sandblasting are exposed to higher than permissible levels of crystalline silica. Various alterations in humoral immune function have been reported in silicosis patients and workers exposed to silica dust. The aim of this study was to measure antinuclear antibody (ANA) and rheumatoid factor (RF) levels in foundry workers exposed to silica and to compare them with a control group without such exposure. ANA and RF were measured in 78 exposed and 73 non-exposed workers, and standard statistical methods were used to compare them. The two groups did not significantly differ in age and smoking. Mean work duration of the exposed and non-exposed workers was (14... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585004 Sun, 31 May 2009 23:00:00 +0100 2585004 http://www.medworm.com/index.php?rid=2585003&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581213%26dopt%3DAbstract This study has revealed a significant disagreement in the estimated degree of pleural and parenchymal asbestos pulmonary disease. This is why we believe high-resolution computed tomography (HRCT) should also be used as a part of international classification. PMID: 19581213 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585003 Sun, 31 May 2009 23:00:00 +0100 2585003 http://www.medworm.com/index.php?rid=2585002&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581214%26dopt%3DAbstract Authors: Ujević B, Habek JC, Habek D The aim of this study was to determine the incidence of N. gonorrhoae (NG) and/or C. trachomatis (CT) in acute mucopurulent cervicitis (MPC). The study included 617 non-pregnant women with MPC, who had not been receiving any antimicrobial treatment. The average age of patients was 22.2 years. There were no statistically significant differences according to place of residence, education, and marital status. Samples for laboratory analysis were collected using a routine procedure; NG was identified using the cytochrome oxidase test and Gram staining. CT was isolated on McCoy cell culture and stained with Lugol solution. NG was isolated in three women (0.8%) and CT in 58 women (9.4%). Fifty-six of the CT-positive patients were nullipara and only ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585002 Sun, 31 May 2009 23:00:00 +0100 2585002 http://www.medworm.com/index.php?rid=2585001&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581215%26dopt%3DAbstract This article also discusses the influence of light exposure on retinal damage. It shows that very little information is available about the influence of environmental and occupational factors on the eye, and retina and retinal vessels in particular. PMID: 19581215 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585001 Sun, 31 May 2009 23:00:00 +0100 2585001 http://www.medworm.com/index.php?rid=2585000&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581216%26dopt%3DAbstract This article brings a review of current knowledge on the relations between the polymorphisms of some CYPs and drug activity/toxicity and cancer risk. PMID: 19581216 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2585000 Sun, 31 May 2009 23:00:00 +0100 2585000 http://www.medworm.com/index.php?rid=2584999&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581217%26dopt%3DAbstract Authors: Kozul D, Romanić SH This review presents methods for the analysis of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), called dioxins, in soil and sediment. These compounds are produced as by-products of different combustion processes, and because of their persistency and toxicity they present a threat for animal and human health. Due to their high organic matter content, soil and sediment can accumulate dioxins and have become important secondary emission sources. Determining dioxins in these samples is complex because dioxins are present in trace levels and have to be separated from interferences whereas other classes of organic contaminants are present in higher concentrations. After sampling, follows extraction of compounds with a s... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2584999 Sun, 31 May 2009 23:00:00 +0100 2584999 http://www.medworm.com/index.php?rid=2584998&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581218%26dopt%3DAbstract Authors: Skitarelić N, Skitarelić N PMID: 19581218 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2584998 Sun, 31 May 2009 23:00:00 +0100 2584998 http://www.medworm.com/index.php?rid=2319865&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329370%26dopt%3DAbstract Authors: Sarić M PMID: 19329370 [PubMed - in process] (Source: Arhiv za Higijenu Rada i Toksikologiju) Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319865 Sun, 01 Mar 2009 05:00:00 +0100 2319865 http://www.medworm.com/index.php?rid=2319863&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329371%26dopt%3DAbstract Authors: Brzica H, Breljak D, Ljubojević M, Balen D, Micek V, Anzai N, Sabolić I To localise antigens by immunocytochemistry (IC), the samples of tissues or cells are usually denatured by fixation, and either frozen and cryosectioned, or embedded in paraffin before sectioning. p-Formaldehyde (PFA; formalin) is a common fixative, which preserves antigenicity of proteins, but damages the tissue/cell morphology and "masks" the antibody binding sites (epitopes). In order to "unmask" epitopes, some kind of antigen retrieval (AR) is used. The aim of this study was: a) to find an optimal AR method in cryosections of in vivo PFA-fixed kidneys for organic anion transporters (Oat) that reside in the basolateral (Oat1, Oat3) and brush-border membrane (Oat2, Oat5) of the rat renal prox... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319863 Sun, 01 Mar 2009 05:00:00 +0100 2319863 http://www.medworm.com/index.php?rid=2319861&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329372%26dopt%3DAbstract Authors: Kovarik Z, Vrdoljak AL, Berend S, Katalinić M, Kuc K, Musilek K, Radić B We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide] with tabun-inhibited human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro, and its antidotal effect on tabun-poisoned mice and rats in vivo. We compared it with oximes K048 and TMB-4, which have proven the most efficient oxime antidotes in tabun poisoning by now. Tabun-inhibited AChE was completely reactivated by K203, with the overall reactivation rate constant of 1806 L mol(-1) min(-1). This means that K203 is a very potent reactivator of tabun-inhibited AChE. In addition, K203 reversibly inhibited AChE (Ki = 0.090 mmol L(-1)) and BChE (K(i) = 0.91... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319861 Sun, 01 Mar 2009 05:00:00 +0100 2319861 http://www.medworm.com/index.php?rid=2319858&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329373%26dopt%3DAbstract Authors: Garaj-Vrhovac V, Gajski G Several studies have reported radioprotective, antimutagenic, anti-inflammatory, antinociceptive, and anticancer effects of bee venom both in the cell and the whole organism. The aim of this study was to assess the effects of a single high dose of 100 microg mL(-1) of whole bee venom in human lymphocytes in vitro over a variety of time spans (from 10 min to 24 h). After the treatment, we used the comet assay and micronucleus test to see the effect of bee venom on the cell. The comet assay confirmed that the venom damaged the DNA molecule. Tail length, tail intensity, tail moment showed a significant increase (P < 0.05). The percentage of long-tailed nuclei (LTN) with the tail length exceeding the 95th percentile also increased in a time-dependent m... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319858 Sun, 01 Mar 2009 05:00:00 +0100 2319858 http://www.medworm.com/index.php?rid=2319854&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329374%26dopt%3DAbstract Authors: Pehnec G, Vadić V, Beslić I, Zuzul S Ozone concentrations were measured at three sites in Zagreb (Croatia) in the summer of 2005. Two measuring sites were in urban areas, while the third site was in a rural area about 30 km to the south from the centre of Zagreb. Hourly ozone averages varied between 1 microg m(-3) and 209 microg m(-3). Average concentrations were the lowest in the rural area, even though elevated concentrations were recorded occasionally. However, the weather conditions during measurements were untypical for that time of the year; over the summer of 2005 there were many rainy and cloudy days. Ozone concentrations at all three sites were the highest on Saturdays and Sundays, and the lowest on Thursdays. All the results were analysed with regard to t... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319854 Sun, 01 Mar 2009 05:00:00 +0100 2319854 http://www.medworm.com/index.php?rid=2319851&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329375%26dopt%3DAbstract This article compares the sorption behaviour of 2,4,6-trichlorophenol, 2,3,4,6-tetrachlorophenol, pentachlorophenol, chlorotriazine atrazine, methylthiotriazine ametryn, methoxytriazine atratone, hydroxyatrazine, and didelakylated atrazine in a topsoil and an aquifer sediment before and after removal of sorbent organic matter and in humic acid. Freundlich isotherm coefficients Kf and 1/n and free energy change (deltaG degrees ) were calculated for all compounds in all sorbents. According to sorbent pH values, chlorophenolate anions and uncharged triazine species dominated in all sorption experiments with topsoil and aquifer sediment. In experiments with humic acid, chlorophenols, atrazine, and didealkylated atrazine existed almost completely as neutral species, whereas protonated species d... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319851 Sun, 01 Mar 2009 05:00:00 +0100 2319851 http://www.medworm.com/index.php?rid=2319849&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329376%26dopt%3DAbstract This article presents a dosimetric study assessing exposure to man-made ionising radiation of local environment and total occupational exposure of two professional workers involved in characterisation, conditioning, and securing of unused radioactive sealed sources. The purpose of the study was to validate a new active electronic dosimeter (AED) of type ALARA OD and to develop a new monitoring method by tracing the external occupational exposure over real time. This method is used to continuously measure and record external radiation doses and, which is a novelty, establish dose rates receiving pattern as a function of real time. Occupational whole body dosimetric results obtained with AED were compared with results obtained with passive dosimetry (film badge and thermoluminiscence). Air, ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319849 Sun, 01 Mar 2009 05:00:00 +0100 2319849 http://www.medworm.com/index.php?rid=2319846&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329377%26dopt%3DAbstract This article brings an overview of data collected in a follow-up study of chronic diseases in general adult population residing in inland and coastal Croatia, that was performed from 1969 to 2007. Despite the selection bias, the sample of volunteers examined in the last follow-up (2005 - 2007), now older than 70, remained as representative as in the previous three follow-ups (1969, 1972, and 1982). Here we report on the design of this prospective cohort study and on papers that have been published as a result. The obtained data could help in promoting healthy living and longevity. The results of our survey might also contribute to the development and implementation of national or international strategies and action plans intended to reduce health risks, and particularly to control and prev... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319846 Sun, 01 Mar 2009 05:00:00 +0100 2319846 http://www.medworm.com/index.php?rid=2319843&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329378%26dopt%3DAbstract Authors: Pizent A, Colak B, Kljaković Z, Telisman S The combined influence of age, smoking, alcohol, blood lead and cadmium concentrations, and serum copper, zinc, and selenium concentrations on prostate-specific antigen (PSA) in serum was investigated in a group of 57 men aged 21 years to 40 years. The subjects had no occupational exposure to metals and no other known reasons suspected of influencing prostate function or metal metabolism. No significant correlation was found between PSA and any of the explanatory variables considered. Nevertheless, when taking into account all of the above-mentioned potentially explanatory variables, the results of stepwise multiple regression showed a significant increase in PSA with respect to an increase in blood lead, and a decrease in PSA w... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319843 Sun, 01 Mar 2009 05:00:00 +0100 2319843 http://www.medworm.com/index.php?rid=2319840&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329379%26dopt%3DAbstract Authors: Avdagić SC, Barić IC, Keser I, Cecić I, Satalić Z, Bobić J, Gomzi M As an important determinant of osteoporotic fracture risk, peak bone density tends to be higher in men than in women. The aim of this study was to see whether young men and women differed in the time and skeletal region of peak bone density. We also investigated the influence of diet and physical activity on bone mass. The study group included 51 male and 75 female students aged 19 to 25 years. Bone mineral density was measured for the spine, total femur, and the distal third of the radius using dual energy x-ray absorptiometry. Dietary data were obtained using a specially designed semiquantitative food frequency questionnaire. Bone mineral density (BMD; g cm(-2)) was higher in bo... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319840 Sun, 01 Mar 2009 05:00:00 +0100 2319840 http://www.medworm.com/index.php?rid=2319837&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329380%26dopt%3DAbstract Authors: Varnai VM, Ljubicić A, Prester L, Macan J The aim of this study was to obtain preliminary exhaled breath condensate (EBC) pH values for healthy adult Croatian subjects, and to evaluate criteria for defining respiratory health of population providing normal EBC pH values in epidemiologic studies. In 109 adults without a history of lower airway symptoms (AS), four groups were described by narrowing the definition of "health" down to 1) without lower AS; 2) without lower and upper AS; 3) without AS, with normal FEV(1) and bronchial normoreactivity; 4) without AS, with normal FEV(1), bronchial normoreactivity, normal total IgE, and with negative skin prick test. Median EBC pH values did not differ between the groups (7.72, 7.73, 7.73, 7.73), but as health criteria got strict... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319837 Sun, 01 Mar 2009 05:00:00 +0100 2319837 http://www.medworm.com/index.php?rid=2319834&cid=s_37275_48_f&fid=37275&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19329381%26dopt%3DAbstract Authors: Radosević-Vidacek B, Kosćec A, Bakotić M, Macan J, Bobić J Different psychosocial characteristics have been associated with allergic disorders. The aim of this study was to examine whether atopic constitution and reports of allergic symptoms were related to personality trait of neuroticism, exposure to stressful life events and estimates of quality of life. Atopy was determined by skin prick test and reports of nasal and pulmonary allergy-related symptoms. Actively working individuals of both genders took part in the study (n=145, age range: 20 to 66 years). The participants were divided in three groups. The first group was composed of those with negative skin prick test and without symptoms (n=57), the second of those with positive skin prick test but ... Arhiv za Higijenu Rada i Toksikologiju journals http://www.medworm.com/rss/comments.php?id=2319834 Sun, 01 Mar 2009 05:00:00 +0100 2319834