Articles of Archives of Medical Science - TERMEDIA publishing house via MedWorm.com

Case report Chronic mucocutaneous candidiasis with endocrinopathy – case report

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:47:02 +0100

We present a case of a 42-year-old man who was treated twice in the Dermatological Department. He was admitted the first time as a 7-year-old boy because of skin and mucosal lesions and then the diagnosis of granuloma candidamyceticum was established. Thirty-one years later he was admitted again with a history of facial skin lesions and blepharitis. For a couple of years he had suffered from diabetes and hypothyroidism. The diagnosis of CMC with endocrinopathy was established in our patient. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Case report Thoraco-omphalopagus twins: different perinatal circumstances, different outcome

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:46:52 +0100

Two pairs of omphalopagus twins were encountered at the Polish Mother’s Health Institution in Lodz, Poland during the past 15 years. In the first set the prenatal diagnosis was not established and the delivery of the twins in a regional hospital was a complete surprise. Both babies died. In the second case the conjoined twins were diagnosed prenatally, surgical separation was successful, and both twins survived. The prenatal identification of conjoined twins is of cardinal importance for the planning of delivery and possible separation. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Tumour necrosis factor gene polymorphisms and migraine in Greek children

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:46:43 +0100

Conclusions: Our data indicate that TNF- and TNF-β gene polymorphisms are not a significant risk factor for migraine without aura in Greek children. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Review paper Opioid peptides and opiate alkaloids in immunoregulatory processes

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:46:31 +0100

Among the various non-neuronal cell types known to express and utilize neuropeptides, those of the immune system have received much attention in recent years. In particular, comparative studies in vertebrates and invertebrates have shown that endogenous opioid peptides are engaged in receptor mediated autoregulatory immune and neuroendocrine processes. The majority of these immune processes are stimulatory, as determined by their effects on conformational changes indicative of immunocyte activation, cellular motility, and phagocytosis. Endogenous opioid peptides form an effective network of messenger molecules in cooperation with cytokines, opiate alkaloids, and certain regulatory enzymes (neutral endopeptidase 24.11). Peptide-mediated immunostimulatory effects observed in this system are ...

Review paper Endogenous reward mechanisms and their importance in stress reduction, exercise and the brain

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:46:16 +0100

Stress can facilitate disease processes and causes strain on the health care budgets. It is responsible or involved in many human ailments of our time, such as cardiovascular illnesses, particularly related to the psychosocial stressors of daily life, including work. Besides pharmacological or clinical medical treatment options, behavioral stress reduction is much-needed. These latter approaches rely on an endogenous healing potential via life-style modification. Hence, research has suggested different ways and approaches to self-treat stress or buffer against stressors and their impacts. These self-care-centred approaches are sometimes referred to as mind-body medicine or multi-factorial stress management strategies. They consist of various cognitive behavioral techniques, as well as rela...

Clinical research Normalization of the Verbal Fluency Test on the basis of results for healthy subjects, patients with schizophrenia, patients with organic lesions of the chronic nervous system and patients with type 1 and 2 diabetes

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:46:06 +0100

Conclusions: This observation is consistent with the neurodevelopmental hypothesis of schizophrenia, in which cognitive functions of the frontal lobe (e.g. verbal fluency) play a major role in the psychopathological picture. We have also demonstrated that in patients with type 1 and 2 diabetes verbal fluency is comparable with healthy subjects. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Aluminium and lead abnormalities in children on haemodialysis: relationship with some medications

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:45:33 +0100

Conclusions: The blood level of trace metals of these HD patients was not related to their medications except for the EPO dose. However, caution must be exercised in interpreting this result as dose and duration of medication may play an important role. Al and Pb over load may be considered from the causes of inadequate response to epoetin therapy. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Successes and pitfalls of chronic peritoneal dialysis in infants – a Polish nationwide outcome study

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:45:25 +0100

Conclusions: The results of our survey have shown that the management of dialysed infants is still a challenge for the medical team and families, but long-term results of the therapy are encouraging. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research The effects of L-thyroxin replacement therapy on bone minerals and body composition in hypothyroid children

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:45:14 +0100

Conclusions: Levothyroxine 4 treatment in hypothyroid children does not alter bone metabolism and body composition (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Is there a gender difference in associates of adolescents’ lifetime illicit drug use in Tehran, Iran?

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:45:01 +0100

Conclusions: Understanding this gender difference in predictors of lifetime use of illicit drugs in high school adolescents facilitates the design of gender-sensitive drug use preventive programmes. It seems that family variables may have more value in prevention of illicit drug use in male adolescents. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Functional scoliosis caused by leg length discrepancy

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:44:51 +0100

Conclusions: Leg length discrepancy equalization results in elimination of scoliosis. Leg length discrepancy < 2 cm is a static disorder; that is why measurements should be performed in a standing position using blocks of adequate thickness and the position of the posterior superior iliac spine should be estimated. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Technique of transurethral needle core biopsy to confirm invasive bladder cancer staging

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:44:35 +0100

Conclusions: TUcoreBxBT in cases of clear suspicion of invasive bladder cancer is a simple, short and safe procedure which makes it possible to collect reliable material for microscopic examination. TUcoreBxBT is less invasive than standard TURBT only in diagnosis and staging of invasive tumours, and seems to be effective in selected cases to confirm malignancy before radical cystectomy. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research The significance of Y chromosome microdeletion analysis in subfertile men with clinical variocele

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:44:20 +0100

Conclusions: The routine performance of pre-operative Yq microdeletion analysis in patients with clinical varicocele does not seem to be cost-effective but the omission of patients with mild oligozoospermia would have subjected them to an unnecessary varicocelectomy and/or further ICSI applications and also would have caused the failure of referral for genetic counselling. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Intraocular matrix metalloproteinase 2 and 9 in patients with diabetes mellitus with and without diabetic retinopathy

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:44:07 +0100

Conclusions: Increased activities of MMP-2 in aqueous humour of patients with PDR may be related to the disease process and support the hypothesis that MMP-2 may be of particular importance in diabetic retinal neovascularization. MMP-9 may be activated at a certain disease stage only. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Determining entropy values equivalent to the bispectral index values during sevoflurane anaesthesia

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:43:54 +0100

Conclusions: Based on this observation, we think that general anaesthetic agents that might cause severe hypotension could be more safely administered under entropy monitoring. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Antiviral activity of borage ( Echium amoenum )

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:43:43 +0100

Conclusions: These results may provide a justification for the traditional use of the Iranian borage flower for infectious diseases and antifebrile activity. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Value of α-smooth muscle actin and glial fibrillary acidic protein in predicting early hepatic fibrosis in chronic hepatitis C virus infection

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:43:32 +0100

Conclusions: Glial fibrillary acidic protein could represent a more useful marker than α-SMA of early activation of HSCs in CHC patients and seems to be an early indicator of hepatic fibrogenesis. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Relationship between codon 249 mutation in exon 7 of p53 gene and diagnosis of hepatocellular carcinoma

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:43:20 +0100

Conclusions: The present study supports the view that the incidence of point mutation of p53 codon 249 mutations in exon 7 of the p53 gene may not play a role in carcinogenesis of HCC in Egyptian patients. Also, genetic polymorphism in HSP70 was not associated with high risk of future development of HCC. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Buerger’s disease as an indicator of socioeconomic development in different societies, a cross-sectional descriptive study in the North-East of Iran

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:43:06 +0100

Conclusions: There is a lack of correspondence between BD and decline in the prevalence of smoking in developed countries. Also, duration and smoking habit varied in the studied patients. On the other hand, the strong dependence of BD on low socioeconomic conditions, as revealed in this research, implies that socioeconomic status may be a risk factor for initiation of BD. Moreover, the prevalence of BD might be an indicator of socioeconomic development in different societies. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research A case series: Egyptian experience in using chemical pleurodesis as an alternative management in refractory hepatic hydrothorax

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:42:59 +0100

Conclusions: The procedure appears to be indicated for these fragile patients especially when medical therapy fails. Chemical pleurodesis deserves to be considered as an alterative therapy in such patients. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Myocardial performance index after surgical correction of ventricular septal defects

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:42:49 +0100

Conclusions: Myocardial performance index is a useful index for measurement of the left and right ventricular function. It correlates significantly with the ejection fraction, fractional shortening, VSD size, and the left ventricular size. It also significantly predicts the outcome of VSD surgery. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Environmental toxin 4-nonylphenol and autoimmune diseases: using DNA microarray to examine genetic markers of cytokine expression

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:42:32 +0100

Conclusions: 4-Nonylphenol may initiate its toxic effects and pose a risk to autoimmunity-prone individuals by eliciting effects up to 4 times more potent than estrogen. Overall, exposure to 4-NP may contribute to autoimmune susceptibility and/or exacerbate existing autoimmune conditions by dysregulating normal expression of cytokines. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Chronic alcohol exposure increases ganglia endogenous morphine levels

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:42:22 +0100

Conclusions: By understanding multiple debilitating effects of alcohol on “morphinergic” signaling, we may understand the ravages of neural processes associated with alcohol abuse and how its treatment may be made more effective. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Review paper Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:42:13 +0100

The NINDS trial demonstrated for the first time the effectiveness of intravenous thrombolysis in improving outcome after acute ischemic stroke. The absolute benefit of this intervention was 11-13% greater chance of being normal or near normal (MRS  1) at 3 months. However, if patients with severe stroke were considered (NIHSS  20), the absolute benefit dropped to 5-6%, indicating that IV thrombolysis may not be as effective for large vessel occlusion. This observation was further supported by TCD studies that clearly demonstrated that large artery occlusions had a recanalization rate of 13-18% with IV rt-PA. Intra-arterial thrombolysis achieves recanalization rates of 60-70%. Since tissue viability is clearly important, it is time to stop defining rigid time windows and if ...

Review paper Indication for percutaneous aortic valve implantation

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:42:04 +0100

The incidence of valvular aortic stenosis has increased over the past decades due to improved life expectancy. Surgical aortic valve replacement is currently the only treatment option for severe symptomatic aortic stenosis that has been shown to improve survival. However, up to one third of patients who require lifesaving surgical aortic valve replacement are denied surgery due to high comorbidities resulting in a higher operative mortality rate. In the past such patients could only be treated with medical therapy or percutaneous aortic valvuloplasty, neither of which has been shown to improve mortality. With advances in interventional cardiology, transcatheter methods have been developed for aortic valve replacement with the goal of offering a therapeutic solution for patients who are unf...

Review paper Catechol-O-methyltransferase: potential relationship to idiopathic hypertension

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Jun 2010 13:41:48 +0100

Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E). Accordingly, homeostasis of COMT gene expression is hypothesized to be functionally linked to regulation of autonomic control of normotensive vascular events. Recently, we demonstrated that morphine administration in vitro resulted in decreased cellular concentrations of COMT-encoding mRNA levels, as compared to control values. In contrast, cells treated with E up regulated their COMT gene expression. In sum, these observations indicate a potential reciprocal linkage between end product inhibition of COMT gene expression by E and...

Original research Evaluation of the level of antibodies against Chlamydophila (Chlamydia) pneumoniae in post-surgery heart ischaemia patients and their clinical conditions – a six-year study

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:49:18 +0100

Conclusions: These results show no connection between the serological symptoms of chronic C. pneumoniae infection and coronary complaints evaluated on the CCS scale during a six-year study on post-CABG patients suffering from heart ischaemia. The surgical treatment of heart ischaemia brought about long-term improvement in the coronary condition of the observed group of patients. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Vascular endothelial growth factor in children with cyanotic and acyanotic and congenital heart disease

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:48:46 +0100

Conclusions: Children with cyanotic congenital heart disease have elevated systemic levels of vascular endothelial growth factor directly related to the degree of cyanosis (SaO2 and haemoglobin levels). These findings suggest that the widespread formation of collateral vessels in these children may be mediated by vascular endothelial growth factor. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Screening for coeliac disease among Egyptian children

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:48:01 +0100

Conclusions: Coeliac disease is more common in Egyptian children with refractory iron deficiency anaemia, non-endocrinal short stature and type 1 diabetes than was previously thought; therefore it is mandatory to screen such patients for CD. Serological tests showed fairly good sensitivity and specificity for the diagnosis; however, intestinal biopsy remains the cornerstone for definitive diagnosis of patients with immunological reaction to gluten. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research A meta-analysis on the efficacy and tolerability of natalizumab in relapsing multiple sclerosis

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:47:31 +0100

Conclusions: It seems that using 3 or 6 mg/kg every 4 weeks is the best method of administration of natalizumab for preventing relapse and occurrence of new Gd-enhancing lesions. The current data on the efficacy and safety of natalizumab are insufficient to reach a convincing conclusion and thus further clinical trials are still needed. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Serum proteomic profile analysis for endometrial carcinoma detection with MALDI-TOF MS

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:46:55 +0100

Conclusions: From these results, we could tell that MALDI-TOF MS is a potential tool for diagnosing diseases by the use of serum samples and will be widely used in the future for clinical work. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Characteristics of obstetric fistulas and the need for a prognostic classification system

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:46:20 +0100

Conclusions: A simple, reproducible and universally accepted scientific classification or staging system for OF dealing with outcomes rather than anatomic landmarks should replace the present proposed classification systems for prognostic and ethical purposes. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Vasopressor choice for hypotension in elective Cesarean section: ephedrine or phenylephrine?

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:45:35 +0100

Conclusions: Phenylephrine and ephedrine are acceptable choices to combat maternal hypotension related to spinal anesthesia in elective Cesarean section. Complications of intra-operative nausea and vomiting, tachycardia and bradycardia should be considered when choosing a vasopressor, suggesting phenylephrine may be more appropriate when considering maternal well-being. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research The delivery of prevention programmes for cardiovascular disease and chronic obstructive pulmonary disease in Lodz by primary care physicians

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:45:15 +0100

Conclusions: Participation of primary health care providers in preventative programmes and the rates of their delivery of interventions were low despite additional funding. The correlation between the proportion of physicians with a particular specialisation, involved in CVD and COPD prevention interventions delivery, and the rate of the programme accomplishment was the strongest for family physicians. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Do soluble p55 and p75 TNF- receptor concentrations play a role in women with primary sterility?

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:43:33 +0100

Conclusions: The correlation between endometrium thickness, size of dominating vesicle and concentration of LH compared to concentrations of soluble TNF-α receptors p55 and p75 and their ratio might condition the time of survival of the vesicle or lead to excessive expression of its atresion-leading conditions. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Risk factor control and adherence to treatment in patients with coronary heart disease in the Republic of Srpska, Bosnia and Herzegovina in 2005-2006

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:43:13 +0100

Conclusions: Our data show, despite improvement over recent years, that many persons with CHD in the Republic of Srpska, Bosnia and Herzegovina are neither on recommended treatments nor at target for BP and/or LDL-C. Improved efforts targeted at both physicians and patients to address these issues are needed. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Case report Silent meningioma – a rare cause of stroke in post-cardiopulmonary bypass patients

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:40:44 +0100

In this report, we present an unusual cause of cerebral dysfunction: a meningioma leading to stroke, following coronary artery bypass grafting in a 62-year-old patient. Diagnosis and treatment options of the pathology are discussed with the guidance of the literature. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Case report Epidural haematoma after epidural catheter removal under multiple anticoagulant therapy: report of two cases

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:39:52 +0100

We report two cases of epidural haematoma that probably developed after removal of the epidural catheter in patients receiving multiple anticoagulant and antiplatelet therapy. The first case is a 77-year-old male patient who underwent femoropopliteal artery bypass grafting surgery. The second case is a 77-year-old woman who underwent a semi-total replacement of the right hip, three days after she had a subtrochanteric fracture. Emergency laminectomy was performed in both patients but none experienced a full recovery. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Case report Colorectal cancer in the course of familial adenomatous polyposis syndrome (“de novo” pathogenic mutation of APC gene): case report, review of the literature and genetic commentary

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:38:36 +0100

We report an atypical case of CRC in a patient with FAP caused by 2797-2800delAACA mutation of the APC gene. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Case report Simultaneous human herpesvirus 6-associated encephalitis and Guillain-Barré syndrome in a patient after matched unrelated donor haematopoietic stem cell transplantation

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:37:40 +0100

We report a case of resolving simultaneous GBS and HHV-6-associated encephalitis in a haematopoietic stem cell transplant recipient with preceding reactivation of cytomegalovirus (CMV) infection. According to our knowledge this well-documented case is probably the first report from Poland. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Treatment with double dose of omeprazole increases -endorphin plasma level in patients with coronary artery disease

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:36:50 +0100

Conclusions: Fourteen-day therapy with a double omeprazole dose significantly increases the β-endorphin plasma concentration in patients with CAD. Circulating β-endorphin does not seem to be involved in the mechanism for the “omeprazole test” outcome, although an individually different effect on pain threshold cannot be excluded. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Extract from Aronia melanocarpa fruits potentiates the inhibition of platelet aggregation in the presence of endothelial cells

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:36:15 +0100

Conclusions: It is concluded that the potentiating effect of AM extract on the endothelial cell-mediated inhibition of platelet aggregation clearly depends on the used concentrations of Aronia-derived active compounds. Therefore, despite these encouraging preliminary outcomes on the beneficial effects of AM extract polyphenols, more profound dose-effect studies should certainly be considered before the implementation of Aronia-originating compounds in antiplatelet therapy and the prevention of cardiovascular diseases. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Co-culture with Schwann cells is an effective way for adipose-derived stem cells neural transdifferentiation

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:35:41 +0100

Conclusions: Co-culturing ADSCs and SCs may be a simple, effective and practical way for ADSCs neural transdifferentiation. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Risk factors in Central Poland for the development of superficial and nodular basal cell carcinomas

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:35:07 +0100

Conclusions: Thus the development of particular BCC subtypes is partially dependent on phototype and personal sun behaviour. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Cyclic tensile stretch modulates osteogenic differentiation of adipose-derived stem cells via the BMP-2 pathway

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:33:49 +0100

Conclusions: We indicate that ASCs may sense mechanical loading in a duration-dependent manner and cyclic tensile stretch may modulate the osteogenic differentiation of ASCs via the BMP-2 signalling pathway. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Genetic variability and the risk of myocardial infarction in Poles under 45 years of age

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:31:33 +0100

Conclusions: We found that only MMP1 1G/2G polymorphism is associated with myocardial infarction in the Polish population of individuals younger than 45 years. Clinical factors seemed to play a greater role in the analysed group. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Asymmetrical dimethylarginine and severity of erectile dysfunction and their impact on cardiovascular events in patients with acute coronary syndrome

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:30:40 +0100

Conclusions: Severity of ED and ADMA did not increase the risk of cardiovascular events in follow-up patients with ACS in our study. Larger prospective studies are necessary to evaluate whether ADMA predicts cardiovascular events in patients with ACS. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Perfusion assessed by real-time contrast echocardiography correlates with clinical and echocardiographic parameters in patients with first STEMI treated with PCI – 6-month follow-up

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:30:10 +0100

Conclusions: Myocardial contrast echocardiography results correlated with clinical outcome and recovery of systolic left ventricular function at 6-month follow-up. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Prevalence of use of advance directives, health care proxy, legal guardian, and living will in 512 patients hospitalized in a cardiac care unit/intensive care unit in 2 community hospitals

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:29:42 +0100

Conclusions: The use of AD was 22%, of HCP was 19%, of LG was 16%, and of LW was 5% in patients hospitalized in a CCU/ICU. Educational programs on use of AD and of HCP need to be part of cardiovascular training programs and of cardiovascular continuing medical education. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Evaluation of exercise capacity with cardiopulmonary exercise testing and BNP levels in adult patients with single or systemic right ventricles

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:29:01 +0100

Conclusions: Patients with a morphological right ventricle serving the systemic circulation and those with common ventricle physiology after Fontan operation show markedly reduced exercise capacity. They are also characterized by higher serum BNP concentrations, which do not however correlate with CpET parameters. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Original research Characterization of low density lipoprotein receptor (LDLR) gene mutations in Albania

Articles of Archives of Medical Science - TERMEDIA publishing house — Fri, 30 Apr 2010 13:26:59 +0100

Conclusions: This report describes two LDLR gene mutations accounting for FH in Albania (1646G>A, 81T>C). (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Expert opinion The trigemino-cardiac reflex: a view to the future

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:16:46 +0100

(Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

First Polish Cowden syndrome patient with confirmed PTEN gene mutation

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:16:30 +0100

Cowden syndrome is a rare hereditary disease. Incidence of the disease is conditioned by occurrence of mutations in the PTEN gene. The disease has a frequency of 1/120,000 newborn and it predisposes to the occurrence of hamartoma polyps in the gastrointestinal tract, skin tumours, as well as tumours of the breast, ovary and thyroid. Here we describe the case of a Polish patient diagnosed with Cowden syndrome with an identified mutation in the PTEN gene. The disease course of the patient is described and discussed along with other cases of carriers of substitution 68T>A in the PTEN gene. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Stevens Johnson syndrome after carbamazepine and SJS/TEN overlap syndrome after amoxicillin: case reports and a review

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:16:09 +0100

We present a case of Stevens Johnson syndrome in a child after carbamazepine application and Stevens Johnson/TEN overlap syndrome in an adult after amoxicillin application. On the basis of two reported cases we review the most commonly associated drugs, the postulated pathogenesis, clinical manifestation and management in these severe life-threatening diseases. We especially discuss the controversial systemic corticosteroid therapy. Topical care is also discussed. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Recurrent hypoglycaemia in a type 2 diabetes patient – diagnostic difficulties

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:15:48 +0100

Hypoglycaemia is the most frequent acute complication of diabetes, regardless of the type of diabetes and the treatment method. Hormonally active tumours of the pancreas, insulinomas, which belong to digestive tract neuroendocrine tumours, constitute one of the less frequent causes of hypoglycaemia. This paper presents a case of a 60-year-old type 2 diabetes patient with recurrent hypoglycaemic events, in whom an insulin-secreting hepatic neuroendocrine tumour was diagnosed. We suggest performing a diagnostic workup taking into consideration insulinoma in patients with diabetes who experience frequent otherwise inexplicable hypoglycaemic events, particularly when they recur despite decreased dose or discontinuation of hypoglycaemic agents. (Source: Articles of Archives of Medical Science -...

Spontaneous rupture of adrenal haemangioma mimicking abdominal aortic aneurysm rupture

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:14:37 +0100

Serious bleeding from a ruptured adrenal mass limits preoperative diagnostics and can necessitate urgent laparotomy to control blood loss. A 45-year old man underwent an emergency laparotomy due to severe retroperitoneal haemorrhage causing hypovolaemia. Detailed retroperitoneal dissection after splenectomy and clamping of the abdominal aorta revealed bleeding from a ruptured haemangioma of the left adrenal gland. Following a left adrenalectomy, the patient returned to a stable haemodynamic state. Adrenal haemangiomas are rare, but may cause spontaneous life-threatening haemorrhage. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Case report Recurrent syncope and hypocalcaemic cardiomyopathy as manifestations of Fahr’s syndrome

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:14:10 +0100

In our report we would like to present a case of a 60-year-old patient with epileptic seizures, affective disturbances, only mild neurocognitive disorders and cardiomyopathy. A female patient was taken to the internal ward with a tentative diagnosis of recurrent syncope. Laboratory results disclosed severe hypocalcaemia, hypoparathyroidism, and hypothyroidism. An echocardiogram revealed left ventricle systolic dysfunction. Computed tomography revealed massive intracranial calcifications typical for Fahr’s syndrome. Our patient demonstrated only mild neurological and psychiatric symptoms, but developed hypocalcaemic heart failure. It is possible that some cases of Fahr’s syndrome remain undiscovered, particularly patients taken to internal wards with mild neurological or psychia...

Indirect (chronic) self-destructiveness and modes of suicide attempts

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:13:51 +0100

Conclusions: The implications of the findings are mainly of preventive and therapeutic nature. In the preventative aspect, the subject of interest should be not only persons with a tendency to the active form of indirect self-destructiveness, but also persons exhibiting its passive form. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Bone mineral density, bone turnover markers, lean mass, and fat mass in Egyptian children with congenital adrenal hyperplasia

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:13:33 +0100

Conclusions: Bone mineral density is normal but bone turnover is low in patients with CAH. There is an increase in fat/lean mass in patients with CAH. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Human bocavirus infections in hospitalized Greek children

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:13:09 +0100

Conclusions: HBoV infections occur in Greece mostly among very young children. They accounted for 3.2% of children hospitalized with acute respiratory disease. Cases were observed only in late autumn to early spring. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Left ventricular diastolic abnormalities and the impact of hepatitis C virus infection in multitransfused Egyptian children

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:12:51 +0100

Conclusions: Multitransfused children are more liable to left ventricular diastolic dysfunction suggested by impaired relaxation probably due to iron overload and anaemia. Hepatitis C virus infection is an additional factor which might share in impairing left ventricular systolic function. Left ventricular performance is better preserved when chelation treatment is adjusted to maintain serum ferritin at (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Screening of growth hormone deficiency in short thalassaemic patients and effect of L-carnitine treatment

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:12:35 +0100

Conclusions: Growth hormone deficiency is an aetiological factor in thalassaemic patients with short stature. L-carnitine can promote GH secretion and growth. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Haemophilia in the developing countries: the Iranian experience

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:12:04 +0100

Conclusions: A national formulary based on facilities of the country should be considered and followed by collaboration among the Ministry Of Health, universities and non-governmental organizations. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Can immune parameters be used as predictors to distinguish between pulmonary multidrug-resistant and drug-sensitive tuberculosis?

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:11:25 +0100

Conclusions: The lower levels of CD3/HLA-DR, CD4 (+), Fas (+), and NK, and the higher level of NKT together with gd T cells in patients with MDR-TB compared to those in SP-TB may indicate a profound immune suppression in MDR-TB patients and thereby may denote an accumulation in the bacterial load. Our findings may shed light on the pathogenesis and prognosis of MDR tuberculosis, and may point towards the use of flow cytometry findings as an aid to early diagnosis in MDR-TB patients. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Estimation of TGF-b1 genotypes in Egyptian smokers; association with FEV1 in COPD patients

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:10:39 +0100

Conclusions: The Pro-allele genotype is associated with increased production of TGF-b1, which has a protective role against the development of COPD and is important in preserving the decline of FEV1 in COPD patients. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Preliminary results of prognostic significance of proliferating cell nuclear antigen expression in advanced primary larynx carcinomas and lymph node metastases

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:10:08 +0100

Conclusions: Our data demonstrate that a high proliferation index in primary larynx tumours is retained and increased in corresponding lymph node metastases. Measurement of the fraction of cancer cells stained for PCNA in primary larynx carcinomas can be helpful in selecting tumours with high aggressiveness potential that are more likely to develop neck metastases and thereby in identifying patients who need elective lymph node dissection or additional treatment. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Efficacy of BIO K+ CL1285Ž in the reduction of antibiotic-associated diarrhea – a placebo controlled double-blind randomized, multi-center study

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:09:45 +0100

Conclusions: BIO-K+ is effective for preventing and reducing the severity of AAD in patients receiving antibiotic therapy in a hospital setting. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

The place of antibiotics in management of irritable bowel syndrome: a systematic review and meta-analysis

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:09:15 +0100

Conclusions: Although antibiotics have a statistically significant effect on IBS and bloating, given the evidence for the presence of publication bias, methodological variability of the trials and lack of a precise scientific explanation for the role of bacterial overgrowth in the pathophysiology of IBS, use of antibiotics on a regular basis in IBS patients is not recommended. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Assessment of plantar pressure and balance in patients with diabet

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:08:14 +0100

Conclusions: The data reveal a correlation between postural oscillation and peak plantar pressure on the hindfoot. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Prevalence of transthoracic echocardiographic abnormalities in patients with ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:07:42 +0100

Conclusions: Transthoracic echocardiographic abnormalities are more prevalent in patients with IS than in patients with SAH or ICH. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Short-term results of community-based interventions for improving physical activity: Isfahan Healthy Heart Programme

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:07:10 +0100

Conclusions: We suggest that the synergism resulting from community collaborations has been effective in improving some aspects of PA in our community. The ongoing changes in environmental factors and policies can help in increasing the worksite and transportation PA in later stages of this community-based programme. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Research paper How effective are strategies for non-communicable disease prevention and control in a high risk population in a developing country? Isfahan Healthy Heart Programme

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:06:39 +0100

Conclusions: Interventional activities in IHHP targeting the high risk population seem to be effective in improving lifestyle behaviour, increasing awareness and control of risk factors of the high risk population. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Growth retardation and delayed puberty in children and adolescents with juvenile idiopathic arthritis

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:05:51 +0100

Juvenile idiopathic arthritis (JIA) is the most common joint disorder in developing children. Juvenile idiopathic arthritis is difficult to diagnose and treat. In some patients, signs and symptoms can be frustratingly inconsistent, contradictory or idiosyncratic. Short stature in patients with JIA is usually due to reduced growth in the lower extremities, and only rarely due to reduced growth in the spinal column. In some studies, children with JIA were found to have infantile body proportions. Puberty is delayed in children with JIA. In children with chronic arthritic disorders, there is a strong correlation between the activity of the disease and the age of puberty. The main goals in reducing growth retardation in children with JIA are promoting timely remission and reducing the duration...

Methods of evaluation of autonomic nervous system function

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:05:33 +0100

Disturbances of the autonomic nervous system play a crucial role in the pathogenesis and clinical course of many diseases. Recently, rapid development has occurred in the clinical assessment of autonomic function. Various procedures have been described as diagnostic tools to monitor autonomic dysfunction. Some of them are mostly used for research purposes. Many, however, have found their place in routine clinical evaluation. Our paper presents selected methods of assessment of the autonomic nervous system with particular emphasis on those that are useful in diagnosis and treatment of diseases of the cardiovascular system. We discuss multiple tests based on cardiovascular reflexes, methods of studying heart rate variability as well as direct catecholamine measurements. Moreover, we outline ...

Effects of drugs on the efficacy of radioiodine (131I) therapy in hyperthyroid patients

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:04:44 +0100

The treatment of hyperthyroidism is targeted at reducing the production of thyroid hormones by inhibiting their synthesis or suppressing their release, as well as by controlling their influence on peripheral tissue (conservative therapy, medical treatment). Radical treatment includes surgical intervention to reduce the volume of thyroid tissue or damage of the mechanisms of thyroid hormone synthesis by radioiodine (131I) administration. Radioiodine ( 131I) is a reactor radionuclide, produced as a result of uranium decomposition and emission of β and γ radiation. The therapeutic effects of the isotope are obtained by the emission of β radiation. In the paper, the effects of administered drugs (antithyroid, glucocorticosteroids, lithium carbonate, inorganic iodine, β-bloc...

Review paper The first sport injuries in the history of medicine

Articles of Archives of Medical Science - TERMEDIA publishing house — Tue, 09 Mar 2010 16:04:01 +0100

Medical science is as old as human history and the need for disease treatment. Archivists, researchers and historians are collaborating in the project to preserve the documentary inheritance and make the medical science useful to the public. This research aims to identify and analyze the first registered sport injuries in the history of medicine. After a review of the literature, the Homeric epics, the texts of the first historical period of ancient Greece, were identified and analyzed as the texts which contain the first sport injuries in world history. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Case report Extramedullary relapse of acute myelogenous leukaemia due to chronic GVHD as a complication of allogeneic HSCT

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 14:08:10 +0100

We report a 41-year-old man with AML and unfavourable complex chromosome abnormalities who was treated with alloHSCT in first complete remission. Two years after transplant due to limited chronic GVHD this patient presented painful oedema around the left wrist. Histology of the soft tissue tumour, found in CT scanning of this wrist, revealed isolated extramedullary (EM) leukaemia relapse. He was treated with surgery, local radiotherapy and systemic chemotherapy. This case suggests that the anti-leukaemic effect of GVHD in EM sites might not be effective. Moreover, there is a possibility that GVHD predisposes to isolated EM relapses of leukaemia. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Case report Efficacy of cyclosporin A in the treatment of acute posterior multifocal placoid pigment epitheliopathy

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 14:06:03 +0100

Aim of the study is report a case of a female patient with acute posterior multifocal placoid pigment epitheliopathy (APMPPE) in whom remission was obtained after systemic cyclosporin A treatment had been applied. The presented case confirms the efficacy of oral cyclosporin A (Sandimmun Neoral) treatment in selected types of choroiditis including patients with APMPPE resistant to steroid therapy. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Case report Combination of monoclonal antibody (Bevacizumab) and chemotherapy (FOLFIRI) in palliative treatment of metastatic adenocarcinoma of the small bowel (SBC): case report and review of the literature.

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 14:05:00 +0100

Small bowel cancer (SBC) is very rare malignancy. Annually about only 89 new cases of SBC are diagnosed in Poland (0.1-0.3%) of all malignancies and approximately 1% of gastrointestinal cancers. The prognosis of metastatic SBC is rather poor. The median survival of patients undergoing chemotherapy is approximately 14 months. Small bowel cancer is considered refractory to chemotherapy. Various anticancer agents have been tested in palliative chemotherapy of SBC: 5-Fluorouracil (5-FU), Cisplatin, Adriamycin, Mitomycin C, Oxaliplatin, Irinotecan, Carboplatin. Here we report a rare case of metastatic SBC with complete response (CR) after combination treatment with monoclonal antibody (Bevacizumab) and FOLFIRI (5-FU, Leukovorin, Irinotecan). The patient is alive without disease progression 28 m...

Case report Salicylate-induced Fanconi-like syndrome

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:59:35 +0100

We describe a new case of salicylate-induced reversible Fanconi's syndrome in a 28-year-old Cypriot male who ingested 50 g of acetylsalicylic acid with suicidal intent. To our knowledge, this is the second case ever described. It is suggested that clinicians should be aware of this salicylate intoxication-induced complication. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

CASE REPORTS: Aortic thrombosis as a complication of intraaortic balloon

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:57:42 +0100

Intra-aortic balloon counterpulsation is often used in critically ill patients with cardiac disease. Commonly accepted indications for its use include cardiogenic shock and mechanical complications of acute myocardial infarction (e.g. ventricular septal defect). The potential benefits of counterpulsation must be weighed against its possible severe thrombotic and hemorrhagic complications. Here we describe a 72-year old female with interventricular septum rupture complicating the course of acute myocardial infarction, in whom the intra-aortic balloon was used to stabilize the circulation prior to the surgery. Despite anticoagulation she developed a thrombus in the abdominal aorta. The risk – benefit ratio and possible ways to predict the complications are discussed. (Source: Articles ...

Case report Aortic thrombosis as a complication of intraaortic balloon

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:57:42 +0100

Mini-Symposium on Food Vulnerability in Society: Sentinal Chemical Messenger Vulnerability: food safety and research are common denominators in guaranteeing food safety and defense concerns in any society

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:56:32 +0100

(Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Mini-Symposium on Food Vulnerability in Society: Sentinal Chemical Messenger Opiate processes in poultry

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:55:23 +0100

The chicken is one of the most common widespread domesticated animals in the world. We rely on them as a primary source of food and consume both their meat and eggs; therefore their overall health should be of great concern and relevance. In this regard, opioid peptide and opiate alkaloid processes in mammals and invertebrates have functions that transcend their actions as anti-nociceptive agents. Many reports document their presence and action in many different physiological processes, such as neural, immune, vascular and digestive systems. Since poultry are the closest living animals to dinosaurs we examined these animals to determine if they too had an endogenous opioid system that was diffuse in function and presence. Indeed, poultry contain such an opioid system, which includes many p...

Mini-Symposium on Food Vulnerability in Society: Sentinal Chemical Messenger Mytilus edulis opiate processes

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:50:37 +0100

Mytilus edulis, a marine bivalve mollusk, exists in many coastal marine environments. It also serves as a common food with a high level of commercialization. Therefore their overall health should be of great concern and relevance to the human population. Studies in the past 30 years have demonstrated considerable conservation in opiate and opioid peptide processes between invertebrate and humans, including the chemical messengers themselves, as well as their respective receptors. These same messengers may serve as an indication of their over all health. Known evolutionary relationships with all animals and the presence of similar or identical processes, specifically in mollusks, make Mytilus edulis an ideal organism for the study of these processes as a model system. In this review, we mai...

Mini-Symposium on Food Vulnerability in Society: Sentinal Chemical Messenger Morphine signaling in Bos taurus and Equus caballus

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:48:02 +0100

The presence of morphine and the mu opioid receptor has been demonstrated in cells from the nervous, endocrine, immune, vascular, reproductive, respiratory, and digestive systems of mammals. The understanding of morphinergic signaling in domestic animals is vital for properly managing this commercially valuable resource. This review discusses the known functions of mu opioid receptors in Bos taurus and Equus caballus. Morphine has been shown to regulate the release of hormones and neurotransmitters in these animals in diverse tissues. The mu opioid receptor is also present on equine gametes and controls key functions of these reproductive cells. Evidence for the presence of the mu opioid receptors in bovine blood, heart, spleen and bone marrow is discussed. Given the widespread occurrence ...

MINI-SYMPOSIUM ON FOOD VULNERABILITY IN SOCIETY: Sentinal Chemical Messengers: Endocannabinoid signaling transcends pain

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:39:32 +0100

On a comparative level D9-tetrahydrocannabinol has been shown to have actions in diverse organisms that extend into invertebrate phyla. Furthermore, these same animals have been found to contain endogenous cannabinoid-like molecules with correspondingly high affinity and selective receptors for these chemical messengers. Interestingly, cannabinoid receptors when activated by their respective ligand appear to be coupled to constitutive nitric oxide release in diverse tissues. Cannabinoid actions include modulatory roles in immune, vascular, neural and other tissues, demonstrating that their influence is widespread in different physiological systems. The fact that similar signaling with the same molecules, receptors and nitric oxide release also occurs in invertebrates speaks to the origin o...

Mini-Symposium on Food Vulnerability in Society: Sentinal Chemical Messengers Endocannabinoid signaling transcends pain

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:39:32 +0100

Clinical research Congenital anomalies associated with anorectal malformations – 16-year experience of one surgeon

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:37:31 +0100

Conclusions: Children with ARMs have a high incidence of associated congenital anomalies. Neonates born with ARMs should be evaluated in search of anomalies of other organs and systems, because these additional defects are responsible for morbidity and mortality in patients with anorectal malformations. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Inappropriate restriction of dietary gluten and associated bone acquisition and bone density in Egyptian children with coeliac disease

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:33:42 +0100

Conclusions: Egyptian children with CD not adherent to GFD had BMD and BMC values significantly lower than in controls. These results emphasize that compliance to GFD is the main challenge for the patients and physicians. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Physical development and pulmonary function in children and adolescents treated at two cystic fibrosis treatment centres in Poland

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:31:58 +0100

Conclusions: A full-scale study is underway to determine the effect of the type of CFTR gene mutation and infection caused by P. aeruginosa on pulmonary function in children with cystic fibrosis treated at specialized care facilities in Poland. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Profile of patients with newly diagnosed HIV in the Łódź region in Poland from 1996 to 2005

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 13:01:03 +0100

Conclusions: We did not observe a stable trend of change in the profiles of newly diagnosed patients, in our region, despite some periodic differences. In 2005, a statistically significant decrease in the number of infections caused by intravenous drug use was observed. This drop had a substantial effect on the frequency of HCV co-infection. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research A preliminary study: matrix metalloproteinase expression as an indicator of the hazards of shisha (nargila) smoking

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:53:18 +0100

Conclusions: Smoking shisha induces expression of metalloproteinases in BAL as much as in smoking cigarettes; moreover, it has a highly deleterious effect on pulmonary function. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Fexofenadine with either montelukast or a low-dose inhaled corticosteroid (fluticasone) in the treatment of patients with persistent allergic rhinitis and newly diagnosed asthma

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:47:41 +0100

Conclusions: The combination of fexofenadine with either montelukast or a low-dose inhaled corticosteroid (fluticasone) equally reduces the serum sICAM-1 concentration and gives the same clinical effect in patients with persistent allergic rhinitis and newly diagnosed asthma. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Local and systemic 20S proteasome release in patients with stenting of stenotic saphenous vein bypass grafts – a pilot study

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:46:39 +0100

Conclusions: We propose that release of 20S proteasome from an atherosclerotic lesion may reflect progression of coronary atherosclerosis and could possibly serve as a biomarker. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction: incidence, a simple risk score, and prognosis

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:41:14 +0100

Conclusions: Contrast-induced nephropathy in patients with STEMI undergoing primary PCI is associated with a markedly increased risk of major cardiovascular events as well as in-hospital and long-term mortality. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research The first cut-off points for generalized and abdominal obesity in predicting lipid disorders in a nationally representative population in the Middle East: The National Survey of Risk Factors for Non-Communicable Diseases of Iran

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:39:16 +0100

Conclusions: The optimal cut-off points provided in the current study might serve as a public health action threshold in the Middle East population. The very high prevalence of high TG and low HDL-C suggest that current guidelines for screening lipid disorders that are based on total and LDL cholesterol should consider such ethnic differences. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Editorial commentary: Aspirin resistance: more emphasis on definition and appropriate use of platelet function tests is needed

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:35:52 +0100

Commentary on The influence of aspirin resistance on non-fatal coronary events following percutaneous coronary interventions (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Editorial commentary Aspirin resistance: more emphasis on definition and appropriate use of platelet function tests is needed

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:35:52 +0100

Clinical research The influence of aspirin resistance on non-fatal coronary events following percutaneous coronary interventions

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:31:33 +0100

Conclusions: Despite regular treatment with aspirin, the incidence of aspirin resistance was significantly higher in patients who developed non-fatal coronary events on long term follow-up following elective PCI. Thus, these findings suggest that aspirin resistance might be an important risk factor that could affect the outcome following PCIs. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

CLINICAL RESEARCH: Determinants of awareness, treatment and control of hypertension in Isfahan, Central Iran

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:30:27 +0100

Conclusions: The awareness of patients about HTN was high but the treatment and control of it was not adequate. Determination of factors associated with them is necessary for control of HTN. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Determinants of awareness, treatment and control of hypertension in Isfahan, Central Iran

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:30:27 +0100

Therapeutic and protective effect of oxymetholone against mortality induced by gamma irradiation in mice

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:28:44 +0100

Conclusions: Oxymetholone had potential effects on increasing survival rate when administered after γ irradiation in mice at divided low doses. With the therapeutic effects of oxymetholone, it can be used for reducing mortality induced by γ irradiation after exposure to irradiation. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Therapeutic and protective effect of oxymetholone against mortality induced by γ irradiation in mice

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:28:44 +0100

Basic research The use of curcumin in obstructive jaundice

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:27:43 +0100

Conclusions: The results of the current study revealed that curcumin improved hepatic functions and reduced hepatic injury by minimizing oxidative stress, decreasing the liver lipid peroxidation, reducing glutathione and as a result recovering the scavenger enzyme activity. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Hepatic mRNA expression of histone (H3): an early predictor of tumorgenic changes in chronic hepatitis C

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:26:09 +0100

Conclusions: It could be concluded that alterations of hepatic expression of histone H3 mRNA quantitatively (increased expression) and qualitatively (nuclear-cytoplasmic shift) may be used for early prediction of tumorgenic changes in CHC. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Changes of the glutathione enzymatic redox system in human gastrointestinal tract tumours

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:24:37 +0100

Conclusions: Changes of lipid peroxidation and GSH levels, and GSH-dependent enzyme activities, suggest that gastrointestinal tract tumours are under the influence of oxidative stress. These results indicate that the glutathione enzymatic redox system is an important mechanism for protection of cancer cells against increased levels of ROS and may point to its role in facilitating development of gastrointestinal tract tumours. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

BASIC RESEARCH: Carrier selection for bone marrow mesenchymal stem cells transplantation in periodontal regeneration: calcium alginate or fibrin gel?

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:23:15 +0100

Conclusions: Considering these factors, the potential immunological rejection risk of fibrin glue, and the advantages of calcium alginate in simple manipulation and lessened interference, calcium alginate might be more suitable as a cell-carrier for bone marrow mesenchymal stem cells transplantation in periodontal regeneration. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Carrier selection for bone marrow mesenchymal stem cells transplantation in periodontal regeneration: calcium alginate or fibrin gel?

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 30 Dec 2009 12:23:15 +0100

Case report Extrapulmonary tuberculosis following allogeneic stem cell transplantation – a difficult and late diagnosis

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:50:18 +0100

We report a case of a 54-year old man after reduced intensity conditioning regimen allogeneic stem cell transplantation, without known personal or family history of tuberculosis, who presented knee joint, skin and bone marrow involvement by a Mycobacterium tuberculosis infection. A delay from the onset of the first symptoms to the confirmed diagnosis of tuberculosis was about 2 months in this case. Despite this delay, our patient successfully recovered after 4-tuberculostatics followed by 2-tuberculostatics therapy. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Case report Insulinoma in a patient with long lasting type 2 diabetes

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:49:46 +0100

In conclusion, insulinoma must be taken into consideration as a reason for hypoglycaemia in type 2 diabetes, however the coincidence of these two diseases is extremely rare. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Eotaxin (CCL11), TARC [thymus and activation-regulated chemokine (CCL17)], MCP-1 (CCL2) and CCR-1, CXCR-1, CXCR-2 expression in dermatitis herpetiformis and bullous pemphigoid

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:48:37 +0100

Conclusions: Our research leads to the assumption that chemokines may play a role in the activating and recruiting eosinophils and neutrophils and suggest that difference in chemokine expression pattern may contributes to variations of the cellular infiltration and tissue damage in DH and BP patients. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Pica: a frequent symptom in iron deficiency anemia

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:47:23 +0100

Conclusions: As a result, pica is a frequent finding in IDA, and patients with and without pica have similar characteristics. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Assessment of selected oxidative stress parameters in patients with Wilson’s disease

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:47:06 +0100

Conclusions: Higher erythrocyte activities of the antioxidative enzymes and total serum antioxidative status in patients with Wilson’s disease confirm activation of the antioxidative system in this group of patients. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Transvaginal doppler sonography for assessment the response to radiotherapy in locally advanced squamous cervical cancer: a preliminary study

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:45:13 +0100

Conclusions: TVS is useful for estimation of uterine cervix during radiation therapy due to locally advanced cervical cancer, but its usefulness in prediction of progression of the cancer is rather low. The value of the assessment of RI in descending branches of uterine arteries in monitoring the treatment of the cervical cancer was not confirmed. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research The ERCC2 K751 polymorphism is associated with breast cancer risk

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:44:11 +0100

Conclusions: We conclude that not only G/G and T/T in our patients was not associated with breast cancer risk but also there is a relation between presence of G/T and increasing of breast cancer risk. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Lung parenchymal involvement and sputum bacteriology in tuberculous pelurisy: correlation with pleural fluid biochemical parameters

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:43:11 +0100

Conclusions: We concluded that degree of inflammation in TP might be affected by simultaneous pulmonary parenchymal changes and sputum bacteriology. It might be suggested that TP might be a different manifestation of pulmonary TB rather than an extra-pulmonary disease. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Effect of treadmill-based gait training on the stationary balance of elderly individuals

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:42:49 +0100

Conclusions: The results of the present study indicate that a specific exercise program, such as treadmill-based gait training, which is a dynamic activity, can improve stationary balance in successful elderly women. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Evaluation of bone mineral density and bone turnover markers in Egyptian children with juvenile rheumatoid arthritis

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:42:01 +0100

Conclusions: JRA patients had lower BMD, higher frequency of low BMD (more prominent in the femoral neck) and higher OPG and RANKL levels compared with healthy children; suggesting that they may be at risk of developing premature osteoporosis and fractures later in life. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Variability in the response to dexamethasone treatment in term neonates with respiratory failure

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:40:38 +0100

Conclusions: Improvement in lung function and mechanics and a decrease in doses of pressors could be detected within 12 h of initiation of dexamethasone therapy. Changes observed in this study can be useful in designing future randomized controlled trials. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Inflammatory process modulation in children with cystic fibrosis submitted to aerobic training

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:40:02 +0100

Conclusions: We may infer that aerobic exercise training maintained the inflammatory process stable and increased exercise capacity in patients with CF. Thus, the measurement of systemic inflammatory response may be a variable to determine whether a proposed training program will trigger greater inflammation. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Biochemical markers of endothelial dysfunction in pediatric nephrotic syndrome

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:39:29 +0100

Conclusions: Endothelial dysfunction is related to the activity of the disease and it is reversible. Modulation of endothelial function in NS may offer a novel strategy to reduce progressive renal insult. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Effect of N-acetylcysteine on microalbuminuria in patients with acute respiratory distress syndrome

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:37:17 +0100

Conclusions: NAC improves global hypoxemia in the patients with acute lung injury. Improvement of oxidant/antioxidant balance by NAC increases the survival of patients with ARDS who are under oxidative crisis. Although limitations of this study do not let us to reach a conclusive decision but the impact of microalbominuria as a predictive of survival in ARDS patients receiving NAC seems essential. Conducting larger clinical trials are recommended. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Captopril and losartan modify mitogen-induced proliferative response and expression of some differentiation antigents on peripheral blood mononuclear cells in chronic uraemic patients

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:36:58 +0100

Conclusions: Our in vitro results seem to indicate that captopril and losartan interfere with immune cells and depress some functions of immune cells in chronic uremic patients and healthy subjects. It is very difficult at present to establish significance of these in vitro immunosuppresive effects of captopril and losartan reflects their in vivo action. Its significance for clinical implications necessitates further extensive studies. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research The effect of treatment on lipid peroxidation in patients with subarachnoid haemorrhage

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:36:31 +0100

Conclusions: Surgical and pharmacological treatment of SAH patients restored prooxidant-antioxidant balance. Evaluation of TBARS and CD level, in SAH patients’ peripheral blood may help to monitor the therapy efficiency in normalization of CNS oxygen metabolism. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Patients with diabetes mellitus with ischemic stroke have a higher hemoglobin A1c level and a higher serum low-density lipoprotein cholesterol level than diabetics without ischemic stroke

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:35:50 +0100

Conclusions: Diabetics should have their hemoglobin A1c level reduced to < 7.0% and their serum LDL cholesterol reduced to < 70 mg/dl. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Value of C-reactive protein and IL-6 measurements in type 1 diabetes mellitus

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:35:12 +0100

Conclusions: In type I diabetes there is an increase in the inflammatory markers, hs-CRP and IL-6 denoting subclinical chronic inflammation. These markers correlate significantly with conventional risk factors for vascular disease, namely hypertension, dyslipidemia, high body mass index and glycemic control. Type 1 diabetes patients with a positive family history of type 2 diabetes mellitus have higher hs-CRP and IL-6 levels indicating that they are more prone to cardiovascular complications. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research N-Terminal pro-Brain Natriuretic Peptide in decompansated ventricular septal defect

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:34:46 +0100

Conclusions: NT-proBNP is elevated in VSDs with cardiac decompensation, it is correlated to clinical score and echocardiography parameters. It reflects pressure and volume loads to the pulmonary artery and right ventricle and may help to identify children with VSD and pulmonary hypertension that demands early intervention. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Prevalence of Behçet’s syndrome in patients presenting with venous thrombosis: prospective study in a cardiovascular outpatient clinic

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:31:37 +0100

Conclusions: It is important to keep in mind the differentital diagnosis of Behçet’s syndrome in a cardiovascular outpatient clinic. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Short period of exercise causes rapid increase of serum interleukin 6 with no effect on its soluble receptor

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:30:26 +0100

Conclusions: In healthy males, brief exercise causes significant increase of plasma IL-6 concentration that depends on hemodynamic effects of exercise, whereas the plasma concentration of IL-6 circulating receptor remains stable. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Co-administration of ezetimibe and a statin in management of dyslipidemias: a meta-analysis of clinical trials

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:16:46 +0100

Conclusions: Ezetimibe coadministered with statins is effective in reducing LDL-C in patients who do not attain target LDL-C levels while on statin monotherapy. Simultaneous administration of a statin plus ezetimibe regimen in patients who are treatment-naI¨ve is also efficient at reducing plasma LDL-C. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Do plasma leptin levels predict diastolic dysfunction in patients with hypertension?

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:15:08 +0100

Conclusions: We suggested that leptin levels didn’t predict diastolic dysfunction in patients with hypertension. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Clinical research Study of T-cell stimulation and cytokine release induced by Staphylococcal enterotoxin type B and monophosphoryl lipid A

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:13:20 +0100

Conclusions: Our data suggest that MPL is a suitable adjuvant that probably leads to more sustained effect of SEB. Because the results of our cytokine assay indicate that the level of IFN-g compared with IL-4, SEB + MPL could be a candidate for tumor therapy. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research The effects of palmvitee on d-aminolevulinic acid-induced hyperbilirubinaemia in suckling rats

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:10:43 +0100

Conclusions: Palmvitee administration confers protective effect against hyperbilirubinaemia. However, this administration could lead to a decreased hepatic glucuronidation activity in the hyperbilirubinaemic rat neonates induced by ALA. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Down-regulation of intrahepatic CD16+ and CD56+ immune cells in chronic Hepatitis C virus infection and HCV-related hepatocellular carcinoma

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:06:21 +0100

Conclusions: These data show that CHC is associated with defects in NK cells and CD56+ lymphocytes that correlate with the degree of inflammatory activity and stage of hepatic fibrosis. The reduced CD16+ Kupffer cells in chronic HCV infection and HCC stress the important role of these cells in antiviral and antitumor immunity. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Neural differentiation of periodontal ligament stem cells induced by neurotrophic Schwann cells factors

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:04:23 +0100

Conclusions: PDLSCs could be induced to differentiate into a Schwann cell phenotype by indirect co-culture with heterogeneic Schwann cells, such neural differentiation began as early as 24 h after co-culture, but the most apparent neural differentiation of PDLSCs appeared 14 days later. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Basic research Role of nitric oxide in the plasma lipid profile in the rabbits

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:02:49 +0100

Conclusions: These data suggest that NO donors, used routinely in cardiovascular disease therapy, may increase the levels of HDL and decrease harmful lipoprotein levels and, hence, decrease the risk of hypercholesterolemia and atherosclerosis. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Review paper Role of cyclooxygenase-2 in cervical cancer

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 13:01:36 +0100

Concurrent radiation and chemotherapy is a standard treatment of patients with cervical cancer in FIGO stages IB2-IVA. Chemotherapy given in the same time as irradiation improved survival significant, but not involves all patients. Cancer recurrence is the most common treatment failure in patients with advanced tumor. Further improvement in the treatment of advanced cases is essential. The increasing knowledge about new biologic markers and better ability to predict risk of cancer recurrence is very important for construction of more effective treatment strategies. Currently, there is considerable interest of role of cyclooxgenase-2 in cervical neoplasia. A lot of cancers in different localizations appear to overexpress the cyclooxygenase-2, which may have an important role in carcinogenes...

Review paper Neural stem cell therapy in neurological diseases

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 12:57:18 +0100

Early developmental process of mammalian embryo is almost completely directed by the behavior of stem cells, which is controlled by both environmental and intrinsic factors. These cells commonly subject to dividing, migration, deterioration or death. Comparing to all other tissues in the body, central nervous system has a considerably limited capacity to regenerate. Recent knowledge on neural stem cells has brought novel approaches as to the use of stem cells in the treatment of some neurodegenerative disorders such as Parkinson, Alzheimer disease and amyotrophic lateral sclerosis, as well as in the management of spinal cord injuries. However, scientific literature requires detailed information regarding the proliferation and differentiation of stem cells and the mechanisms controlling the...

Review paper Cholesterol-lowering therapy and cell membranes. Stable plaque at the expense of unstable membranes?

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 22 Oct 2009 12:55:05 +0100

Current guidelines encourage ambitious long term cholesterol lowering with statins, in order to decrease cardiovascular disease events. However, by regulating the biosynthesis of cholesterol we potentially change the form and function of every cell membrane from the head to the toe. As research into cell morphology and membrane function realises more dependencies upon cholesterol rich lipid membranes, our clinical understanding of long term inhibition of cholesterol biosynthesis is also changing. This review of non-cardiovascular research concerning such membrane effects raises important new issues concerning the clinical advantages and disadvantages of the long term use, and broadening criteria, of cholesterol reductions. (Source: Articles of Archives of Medical Science - TERMEDIA publish...

REVIEW PAPER Role of Periodontal Infection in Cardiovascular Disease: A Current Perspective

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 23 Jul 2009 14:02:19 +0100

Oral pathogens play a causal role in Cardiovascular Disease (CVD) that is largely driven by inflammation and host immune response. Clinico-epidemiological and animal studies provide a strong link between periodontal disease (PD) and CVD, both of which are highly prevalent, complex disease processes with common risk factors. Genes involved in inflammation, matrix degeneration and immune response have been implicated in the initiation and progression of both diseases. Recent studies have promoted the discovery of novel pathways and lead molecules thus providing opportunities for developing effective vaccine candidates to control disease progression. Following periodontal therapy, studies have shown reduction in the levels of pro-inflammatory cytokines and acute phase reactants, enhancement o...

Surgical revascularization of myocardium in population of young women. Is it a group of increased operative risk?

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 23 Jul 2009 13:49:40 +0100

Occurrence of myocardial infarction and advanced atheromatosis of coronary arteries in premenopausal women is unusual. Surgical revascularization of myocardium as an established method of ischaemic heart disease (IHD) management is more often used in this subset of patients. In recent years there have been some studies indicating better outcome of female patients after cardiac surgery, especially in the long term, but it is generally believed that women are more exposed to complications and have poorer prognosis after myocardial revascularization procedures compared with males, especially in the youngest groups. It seems that physiological protectors of the cardiovascular system which are present in a healthy population of young women are not effective in a subset with IHD undergoing coron...

BASIC RESEARCH SDF1/CXCR4 signalling promotes mobility of myeloma cells by activation and redistribution of cell surface adhesion molecules

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 23 Jul 2009 13:49:17 +0100

Conclusions: Taken together, it is highlighted that SDF-1/CXCR4 is a critical regulator of MM migration, providing the framework for the inhibitors of this pathway to be used in future clinical trials to abrogate MM trafficking. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

In vitro osteogenesis of rat adipose-derived stem cells: comparison with bone marrow stem cells

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 23 Jul 2009 13:48:40 +0100

Conclusions: The results of our study suggest that ADSCs may have an inferior potential for osteogenesis compared with BMSCs. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

CLINICAL RESEARCH Transplantation of bone marrow stromal mesenchymal cells in the treatment of acute myocardial infarction

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 23 Jul 2009 13:47:45 +0100

Conclusions: Cell therapy with BMSCs seems effective in the early stages of AMI, preventing LVEF worsening and remodelling. Injected cells give origin to muscular and endothelial cells. It is necessary to clarify whether new cells directly derive from injected cells, or originate from resident or circulating cells by stimulation or chemotaxis. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Association of the QRS duration on the resting electrocardiogram with the severity of coronary artery disease in 2,196 patients undergoing coronary angiography for suspected coronary artery disease

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 23 Jul 2009 13:46:59 +0100

Conclusions: The prevalence of a QRS duration ł 120 ms on the resting ECG increased with increasing severity of obstructive CAD. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

Preprocedural C-reactive protein predictive value in angiographic in-stent restenosis after coronary stent placement in patients with stable angina

Articles of Archives of Medical Science - TERMEDIA publishing house — Thu, 23 Jul 2009 13:46:38 +0100

Conclusions: Preprocedural CRP may not predict in-stent restenosis, but strict control of diabetes may improve the outcome after elective coronary stenting. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

LIST OF REVIEWERS – Vol. 4, 2008

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 22 Apr 2009 13:55:18 +0100

(Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

EDITORIAL A medium of science communication in our times

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 22 Apr 2009 13:54:30 +0100

(Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

REVIEW PAPERS Ambulatory blood pressure as a predictor of cardiovascular risk

Articles of Archives of Medical Science - TERMEDIA publishing house — Wed, 22 Apr 2009 13:54:22 +0100

Hypertension is one of the most common primary diagnoses and a known risk factor for cardiovascular disease, stroke and kidney disease. Like many other physiological variables, blood pressure is characterized by long- and short-term variability. Thus, blood pressure measured over extended periods of time, i.e. ambulatory monitoring, is more representative of the actual value than a single office reading. In longitudinal studies, ambulatory blood pressure (ABP) is found to predict future cardiovascular risk better than conventional blood pressure. Not only blood pressure values but also the pattern predicts cardiovascular risk on ABP measurement. Non-dipping blood pressure pattern, i.e. night-time/daytime pressure greater than 0.9, is an independent risk factor for cardiovascular events. Am...