MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Atherosclerosis' source. Wed, 08 Feb 2012 09:32:29 +0100 http://www.medworm.com/index.php?rid=5661050&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28%2522Atherosclerosis%2522%29%2520AND%2520%25222012%252F01%252F31%252000.18%2522%255BMHDA%255D%253A%25222012%252F02%252F05%252022.12%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%2522Atherosclerosis%2522%255BTIAB%255D%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222012%252F01%252F31%252000.18%2522%255BEDAT%255D%29%29 115 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Atherosclerosis" These pubmed results were generated on 2012/02/05PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5661050 Mon, 06 Feb 2012 03:12:01 +0100 5661050 http://www.medworm.com/index.php?rid=5643052&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22275081%26dopt%3DAbstract Authors: Sowers JR PMID: 22275081 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643052 Tue, 31 Jan 2012 05:21:14 +0100 5643052 http://www.medworm.com/index.php?rid=5643051&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22275087%26dopt%3DAbstract Authors: Wang ZH, Shang YY, Zhang S, Zhong M, Wang XP, Deng JT, Pan J, Zhang Y, Zhang W Abstract Insulin resistance triggers the developments of diabetes mellitus and atherosclerosis. Tribbles homolog 3 (TRIB3) is involved in insulin resistance. We aimed to investigate whether TRIB3 is implicated in diabetic atherosclerosis. Sixty 3-week-old apolipoprotein E (ApoE(-/-))/LDR receptor (LDLR(-/-)) mice were randomly divided into chow and diabetes groups. Diabetes was induced by a high-fat and high-sugar diet combined with low-dose streptozotocin. Mice in both groups were randomly divided into vehicle and TRIB3-silencing groups. After transfection, all mice were killed to evaluate the effects of TRIB3 on atherosclerosis. Silence of TRIB3 markedly decreased insulin resistance (P = 0.039... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643051 Tue, 31 Jan 2012 05:21:05 +0100 5643051 http://www.medworm.com/index.php?rid=5643041&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22281221%26dopt%3DAbstract Authors: Radojevic N, Savic S, Aleksic V, Cukic D Abstract It is well known that atrial infarctions are rare comparing to the ventricular. They cannot easily be verified on ECG and the standard autopsy technique does not include a detailed review of the atrial wall, so the atrial infarction often remains undiagnosed. A 63-year-old male was treated and died in an intensive care unit due to decompensated liver insufficiency and cardiac disease following long-lasting alcohol abuse. At autopsy, the extreme cardiomegaly was found, severe atherosclerosis of the anterior descending branch of left coronary artery. The posterior wall of the right atrium was thickened (cca 9 mm) in diameter of cca 3 × 3 cm, and this area was yellowish in the luminal part, while the central part was fille... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643041 Tue, 31 Jan 2012 05:19:26 +0100 5643041 http://www.medworm.com/index.php?rid=5643037&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22282240%26dopt%3DAbstract Authors: Li H, Ding Y, Yi G, Zeng Q, Yang W Abstract Mounting evidence supports that a newly identified regulatory T cell (Treg), CD4(+)LAP(+) Treg, is associated with oral tolerance induction and following inhibition of atherosclerosis, but little is described about whether nasal tolerance to antigen likewise induces the novel Tregs production and the relevant antiatherosclerotic benefit. We investigated the effect of nasal administration of heat shock protein-60 (HSP60) on atherogenesis. HSP60 or phosphate buffer solution (PBS) was nasally administered to six-week-old male ApoE(-/-) mice. At the 10th week after the nasal administration, there was a significant decrease in atherosclerotic plaque areas of aortic roots in the HSP60-treated mice as compared with those in the PBS-trea... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643037 Tue, 31 Jan 2012 05:18:46 +0100 5643037 http://www.medworm.com/index.php?rid=5643036&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22282241%26dopt%3DAbstract Authors: Liao H, Gong J, Zhang W, Guo X Abstract Angiotensin II (ANGII) plays an important role in the pathogenesis of atherosclerosis by inducing proliferation of vascular smooth muscle cells (VSMCs). In our study, we observed the effects of valsartan on proliferation of cultured VSMCs treated with or without ANGII by cell counting and methyl thiazolyl tetrazolium (MTT) assay, and detected the expression of mitofusin 2 (Mfn2), a newly discovered cell proliferation inhibitor and a related cell proliferation signaling pathway protein by Western blotting. ANGII at a concentration of 10(-6) mol/L significantly stimulated VSMCs proliferation, down-regulated the expression of Mfn2 and up-regulated the expression of Raf and ERK1/2. Valsartan inhibited such effects of ANGII at concentrati... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643036 Tue, 31 Jan 2012 05:18:35 +0100 5643036 http://www.medworm.com/index.php?rid=5643055&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22272073%26dopt%3DAbstract CONCLUSION: These data indicate that DGU-derived indicators of the "atherogenic lipoprotein phenotype," including increased TG-rich lipoprotein cholesterol, lower HDL-C and HDL-C subfractions, and a greater proportion of LDL-C carried by more dense LDL particles, are associated with CIMT progression in men and women at moderate risk for coronary heart disease. PMID: 22272073 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643055 Tue, 31 Jan 2012 05:18:07 +0100 5643055 http://www.medworm.com/index.php?rid=5643054&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22272317%26dopt%3DAbstract CONCLUSIONS/SIGNIFICANCE: Our data suggest that loss of RGS5 exacerbates HF-induced obesity, hepatic steatosis, inflammation and insulin resistance. PMID: 22272317 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643054 Tue, 31 Jan 2012 05:18:07 +0100 5643054 http://www.medworm.com/index.php?rid=5643053&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22272346%26dopt%3DAbstract CONCLUSION: IRAK3 is a key inhibitor of inflammation in association with obesity and metabolic syndrome. Our data warrant further evaluation of IRAK3 as a diagnostic and prognostic marker, and as a target for intervention. PMID: 22272346 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643053 Tue, 31 Jan 2012 05:18:07 +0100 5643053 http://www.medworm.com/index.php?rid=5643050&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22275902%26dopt%3DAbstract Authors: Gleissner CA Abstract During atherogenesis, blood monocytes transmigrate into the subendothelial space and differentiate toward macrophages and foam cells. The major driver of monocyte-macrophage differentiation is macrophage colony-stimulating factor (M-CSF). M-CSF-induced macrophages are important promoters of atherogenesis as demonstrated in M-CSF and M-CSF receptor knock out mice. However, M-CSF is not the only relevant promoter of macrophage differentiation. The platelet chemokine CXCL4 also prevents monocyte apoptosis and promotes macrophage differentiation in vitro. It is secreted from activated platelets and has effects on various cell types relevant in atherogenesis. Knocking out the Pf4 gene coding for CXCL4 in Apoe(-/-) mice leads to reduced atherogenesis. Thus,... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643050 Tue, 31 Jan 2012 05:18:06 +0100 5643050 http://www.medworm.com/index.php?rid=5643049&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22276187%26dopt%3DAbstract In conclusion, C. pneumoniae infection of mononuclear cells stimulates IL-1β production dependent on a NLRP3 inflammasome-mediated processing of proIL-1β which is controlled by Rac1. PMID: 22276187 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643049 Tue, 31 Jan 2012 05:18:06 +0100 5643049 http://www.medworm.com/index.php?rid=5643048&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22276189%26dopt%3DAbstract CONCLUSIONS: Our study shows that human LDL and lipoprotein(a) promote changes in the expression of a unique set of arterial proteins which may be early indicators of the metabolic disturbances preceding atherosclerosis. PMID: 22276189 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643048 Tue, 31 Jan 2012 05:18:06 +0100 5643048 http://www.medworm.com/index.php?rid=5643047&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22277355%26dopt%3DAbstract Authors: Nohara R, Daida H, Hata M, Kaku K, Kawamori R, Kishimoto J, Kurabayashi M, Masuda I, Sakuma I, Yamazaki T, Yokoi H, Yoshida M, Abstract (Circ J 2012; 76: 221-229). PMID: 22277355 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643047 Tue, 31 Jan 2012 05:18:06 +0100 5643047 http://www.medworm.com/index.php?rid=5643046&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278288%26dopt%3DAbstract Authors: Menu P, Mayor A, Zhou R, Tardivel A, Ichijo H, Mori K, Tschopp J Abstract Uncontrolled endoplasmic reticulum (ER) stress responses are proposed to contribute to the pathology of chronic inflammatory diseases such as type 2 diabetes or atherosclerosis. However, the connection between ER stress and inflammation remains largely unexplored. Here, we show that ER stress causes activation of the NLRP3 inflammasome, with subsequent release of the pro-inflammatory cytokine interleukin-1β. This ER-triggered proinflammatory signal shares the same requirement for reactive oxygen species production and potassium efflux compared with other known NLRP3 inflammasome activators, but is independent of the classical unfolded protein response (UPR). We thus propose that the NLRP3 inflammaso... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643046 Tue, 31 Jan 2012 05:18:06 +0100 5643046 http://www.medworm.com/index.php?rid=5643044&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22279441%26dopt%3DAbstract Conclusion: Our results suggest that the presence of low and moderate ICA stenosis is one of the factors affecting the neurophysiologic status of CHD patients. It has been assumed that the patients with ≤50% ICA stenoses constitute a high-risk group for cerebral complications after on-pump CABG. PMID: 22279441 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643044 Tue, 31 Jan 2012 05:18:06 +0100 5643044 http://www.medworm.com/index.php?rid=5643040&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22281251%26dopt%3DAbstract CONCLUSIONS: Higher HbA1c is associated with elevated hs-cTnT among persons without clinically evident CHD, suggesting that hyperglycemia contributes to myocardial injury beyond its effects on development of clinical atherosclerotic coronary disease. PMID: 22281251 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643040 Tue, 31 Jan 2012 05:00:00 +0100 5643040 http://www.medworm.com/index.php?rid=5643039&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22281656%26dopt%3DAbstract This article reviews the available data related to the use of CIMT and plaque information in CHD risk prediction. PMID: 22281656 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643039 Fri, 27 Jan 2012 05:00:00 +0100 5643039 http://www.medworm.com/index.php?rid=5643035&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22282305%26dopt%3DAbstract This study seeks to evaluate the clinical findings in patients with SE. Thirty-one patients with necrotic superficial squamous epithelium, with endoscopic white plaques or membranes, but without fungi, were compared with 34 patients having esophageal biopsies done for any purpose other than Barrett's surveillance. Sloughing esophagits patients were older than controls (56 vs 43.5 years) and were more likely to be taking five or more medications (77 vs 32%), especially central nervous system depressants (65 vs 32%) and medications associated with esophageal injury (55 vs 18%). In 69% the plaques were in the distal and/or mid-esophagus; 23% involved the entire esophagus; 8% were limited to the proximal esophagus. There was no correlation between medication history and site. Sloughing esophag... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643035 Fri, 27 Jan 2012 05:00:00 +0100 5643035 http://www.medworm.com/index.php?rid=5643034&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22282402%26dopt%3DAbstract In this study, the synergistic effect of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone (cilostazol) and Ginkgo biloba extract (GbE) was examined in apolipoprotein E (ApoE) null mice. Co-treatment withGbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Co-treatment resulted in a significantly decreased atherosclerotic lesion area compared to untreated ApoE mice. The inflammatory cytokines and adhesion moleculessuch as monocyte chemoattractant-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and VCAM-1which can initiateatherosclerosiswere significantly reduced by the co-treatment of cilostazol withGbE. Further, the infiltration of macrophages into the intima was decreased by co... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643034 Fri, 27 Jan 2012 05:00:00 +0100 5643034 http://www.medworm.com/index.php?rid=5643045&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278375%26dopt%3DAbstract CONCLUSION: Patients with SBI were ranked at moderate risk of neurological complications after CABG between control and BI. Increased age, renal dysfunction, and preoperative cognitive impairment appeared to be strongly associated with SBI. PMID: 22278375 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643045 Thu, 26 Jan 2012 05:00:00 +0100 5643045 http://www.medworm.com/index.php?rid=5643043&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22279598%26dopt%3DAbstract Authors: Mercurio V, Carlomagno G, Fazio V, Fazio S Abstract Insulin resistance is a clinical condition characterized by a decrease in sensitivity and responsiveness to the metabolic actions of insulin, so that a given concentration of insulin produces a less-than-expected biological effect. As a result, higher levels of insulin are needed to maintain normal glucose tolerance. Hyperinsulinemia, indeed, is one of the principal characteristics of insulin resistance states. This feature is common in several pathologic conditions, such as type 2 diabetes, obesity, and dyslipidemia, and it is also a prominent component of hypertension, coronary heart disease, and atherosclerosis. The presence of endothelial dysfunction, related to insulin resistance, plays a key role in the development ... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643043 Thu, 26 Jan 2012 05:00:00 +0100 5643043 http://www.medworm.com/index.php?rid=5643042&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22280336%26dopt%3DAbstract This article reviews the current knowledge of the pathophysiological events contributing to endothelial dysfunction as well as several established and novel treatment options to reverse those changes along with the discussion of recent patents. PMID: 22280336 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643042 Thu, 26 Jan 2012 05:00:00 +0100 5643042 http://www.medworm.com/index.php?rid=5643038&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22281788%26dopt%3DAbstract CONCLUSION: Observation of aortic knob on chest X-ray in hypertensive patients may provide important predictive information of subclinical atherosclerosis. PMID: 22281788 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5643038 Thu, 26 Jan 2012 05:00:00 +0100 5643038 http://www.medworm.com/index.php?rid=5625376&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28%2522Atherosclerosis%2522%29%2520AND%2520%25222012%252F01%252F19%252003.12%2522%255BMHDA%255D%253A%25222012%252F01%252F25%252000.42%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%2522Atherosclerosis%2522%255BTIAB%255D%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222012%252F01%252F19%252003.12%2522%255BEDAT%255D%29%29 109 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Atherosclerosis" These pubmed results were generated on 2012/01/25PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5625376 Wed, 25 Jan 2012 05:42:00 +0100 5625376 http://www.medworm.com/index.php?rid=5608489&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915012000196%2Fabstract%3Frss%3Dyes (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608489 Fri, 20 Jan 2012 14:08:12 +0100 5608489 http://www.medworm.com/index.php?rid=5605152&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28%2522Atherosclerosis%2522%29%2520AND%2520%25222012%252F01%252F12%252009.42%2522%255BMHDA%255D%253A%25222012%252F01%252F19%252003.12%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%2522Atherosclerosis%2522%255BTIAB%255D%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222012%252F01%252F12%252009.42%2522%255BEDAT%255D%29%29 111 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Atherosclerosis" These pubmed results were generated on 2012/01/19PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5605152 Thu, 19 Jan 2012 08:12:00 +0100 5605152 http://www.medworm.com/index.php?rid=5579450&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28%2522Atherosclerosis%2522%29%2520AND%2520%25222012%252F01%252F06%252006.12%2522%255BMHDA%255D%253A%25222012%252F01%252F12%252009.42%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%2522Atherosclerosis%2522%255BTIAB%255D%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222012%252F01%252F06%252006.12%2522%255BEDAT%255D%29%29 102 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Atherosclerosis" These pubmed results were generated on 2012/01/12PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5579450 Thu, 12 Jan 2012 14:42:02 +0100 5579450 http://www.medworm.com/index.php?rid=5563248&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22216405%26dopt%3DAbstract Authors: Siennicki-Lantz A, Elmståhl S Abstract To assess an impact of vascular risk factors on ambulatory blood pressure measurement (ABPM) in the elderly, we followed up a population-based cohort of men from 68 until 82 years, when 104 survivors underwent ABPM. Results. At age 68, hypertension and high clinic blood pressure (CBP) did not predict ABPM level. Smoking and low ankle-brachial index (ABI) predicted higher ABPM variability and pulse pressure (PP), but not absolute ABPM values. At age 82, hypertension, high or increasing CBP, strongly positively correlated with all variables of ABPM. Carotid stenosis, low or declining ABI during followup, correlated with higher nocturnal ABPM and PP. Concluding. Hypertension and vascular risk factors in a cohort of 68-year-old men do no... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563248 Fri, 06 Jan 2012 11:12:11 +0100 5563248 http://www.medworm.com/index.php?rid=5563257&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22213019%26dopt%3DAbstract Authors: Khan SR Abstract Epidemiological studies have provided the evidence for association between nephrolithiasis and a number of cardiovascular diseases including hypertension, diabetes, chronic kidney disease, metabolic syndrome. Many of the co-morbidities may not only lead to stone disease but also be triggered by it. Nephrolithiasis is a risk factor for development of hypertension and have higher prevalence of diabetes mellitus and some hypertensive and diabetic patients are at greater risk for stone formation. An analysis of the association between stone disease and other simultaneously appearing disorders, as well as factors involved in their pathogenesis, may provide an insight into stone formation and improved therapies for stone recurrence and prevention. It is our hypo... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563257 Wed, 04 Jan 2012 05:00:00 +0100 5563257 http://www.medworm.com/index.php?rid=5563251&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215117%26dopt%3DAbstract Authors: Di Geso L, Zardi EM, Afeltra A, Salaffi F, Carotti M, Gutierrez M, Filippucci E, Grassi W Abstract Over the last decade, a growing number of studies have been published supporting the high prevalence of atherosclerosis in rheumatic patients with chronic inflammatory diseases. Ultrasound (US) represents the imaging technique of choice for revealing early atherosclerotic changes at carotids level. New US software, mainly developed to rectify its operator dependence, requires a comparison with conventional technique. The main aim of the present study was to compare conventional and software-guided US in the assessment of intima-media thickness (IMT) of common carotids. Thirty-two consecutive patients with chronic inflammatory rheumatic conditions, presenting at the outpatient... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563251 Wed, 04 Jan 2012 05:00:00 +0100 5563251 http://www.medworm.com/index.php?rid=5563250&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215136%26dopt%3DAbstract CONCLUSIONS:The absence of a modifying effect of ethnicity indicates that the putative benefits of LC-PUFAs with respect to inflammation are pan-ethnic. Future longitudinal studies may elucidate the origin(s) of ethnicity-based differences in LC-PUFA composition and whether certain patterns, that is, high plasma levels of DGLA and low levels of EPA/DHA, contribute to inflammation-associated health outcomes.European Journal of Clinical Nutrition advance online publication, 4 January 2012; doi:10.1038/ejcn.2011.215. PMID: 22215136 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563250 Wed, 04 Jan 2012 05:00:00 +0100 5563250 http://www.medworm.com/index.php?rid=5563258&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22212150%26dopt%3DAbstract CONCLUSIONS: This is a precedent study that found genetic variants of rs12425791 and rs11833579 on chromosome 12p13 are independent predictors of stroke-related mortality or stroke recurrence in patients with incident ischemic stroke in Taiwan. Further study is needed to explore the details of the physiological function and the molecular mechanisms underlying the association of this genetic locus with ischemic stroke. PMID: 22212150 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563258 Tue, 03 Jan 2012 05:00:00 +0100 5563258 http://www.medworm.com/index.php?rid=5563256&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214235%26dopt%3DAbstract Conclusion. Patients with IgAN and an increased ApoB/ApoA-I ratio have a significantly higher risk of developing ESRD compared with patients with a low ratio. Controlled studies are warranted to demonstrate whether interventions focusing on the ApoB/ApoA-I ratio may have beneficial clinical effects. PMID: 22214235 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563256 Tue, 03 Jan 2012 05:00:00 +0100 5563256 http://www.medworm.com/index.php?rid=5563255&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214418%26dopt%3DAbstract CONCLUSIONS: Pre-surgical CD34+/CD144+ numbers are decreased in CABG patients, compared to valvular patients with absence of coronary disease. PMID: 22214418 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563255 Tue, 03 Jan 2012 05:00:00 +0100 5563255 http://www.medworm.com/index.php?rid=5563253&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214843%26dopt%3DAbstract Authors: Silverstein RL Abstract Thrombotic complications represent a highly significant component of morbidity and mortality associated with hypercholesterolemia and atherosclerosis. In this issue of the JCI, Owens et al. report possible mechanisms underlying the prothrombotic, proinflammatory state accompanying hypercholesterolemia. Using rodent, monkey, and human subjects, they show that circulating oxidized LDL and circulating monocyte-derived tissue factor are important instigating factors driving the thrombotic, inflammatory phenotype and, surprisingly, that statin therapy ameliorated the phenotype even in the absence of lowering cholesterol levels. The studies raise the intriguing possibility that therapies directed at pathways generating oxidant stress or pathways involved ... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563253 Tue, 03 Jan 2012 05:00:00 +0100 5563253 http://www.medworm.com/index.php?rid=5563252&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214850%26dopt%3DAbstract Authors: Owens AP, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N Abstract Hypercholesterolemia is a major risk factor for atherosclerosis. It also is associated with platelet hyperactivity, which increases morbidity and mortality from cardiovascular disease. However, the mechanisms by which hypercholesterolemia produces a procoagulant state remain undefined. Atherosclerosis is associated with accumulation of oxidized lipoproteins within atherosclerotic lesions. Small quantities of oxidized lipoproteins are also present in the circulation of patients with coronary artery disease. We therefore... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563252 Tue, 03 Jan 2012 05:00:00 +0100 5563252 http://www.medworm.com/index.php?rid=5563249&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215666%26dopt%3DAbstract Authors: Kakkar R, Hei H, Dobner S, Lee RT Abstract Interleukin 33 (IL-33), a member of the Interleukin 1 cytokine family, is implicated in numerous human inflammatory diseases such as asthma, atherosclerosis and rheumatoid arthritis. Despite its pathophysiologic importance, fundamental questions regarding its basic biology remain. Nuclear localization and lack of an export signal sequence are consistent with the view of IL-33 as a nuclear factor with the ability to repress RNA transcription. However, signaling via the transmembrane receptor ST2 and documented caspase-dependent inactivation have suggested IL-33 is liberated during cellular necrosis to effect paracrine signaling. A complete and precise description of IL-33 behavior is therefore lacking. We determined the sub-cellula... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563249 Tue, 03 Jan 2012 05:00:00 +0100 5563249 http://www.medworm.com/index.php?rid=5563261&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22208333%26dopt%3DAbstract In conclusion, lower serum PON1 activity and albumin might contribute to morbidity and occurrence of other complications such as atherosclerosis and rapid aging in the veterans suffering from late toxic effects of sulfur mustard. PMID: 22208333 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563261 Mon, 02 Jan 2012 05:00:00 +0100 5563261 http://www.medworm.com/index.php?rid=5563254&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22214554%26dopt%3DAbstract Authors: Barrett JR PMID: 22214554 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5563254 Sun, 01 Jan 2012 05:00:00 +0100 5563254 http://www.medworm.com/index.php?rid=5551732&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22200430%26dopt%3DAbstract Authors: Apostolov EO, Basnakian AG, Ok E, Shah SV Abstract The high cardiovascular morbidity and mortality associated with chronic kidney disease (CKD) cannot be explained entirely by traditional risk factors. Urea spontaneously dissociates to form cyanate, which modifies proteins in a process referred to as carbamylation. Carbamylated low-density lipoprotein (cLDL) has been shown to have all of the major biological effects relevant to atherosclerosis, including endothelial cell injury, increased expression of cell adhesion molecules, and vascular smooth muscle cell proliferation. Recent studies indicate that cLDL leads to endonuclease G activation, which participates in cellular injury. In addition, cLDL has been shown to enhance generation of oxidants. Limited human data have d... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551732 Fri, 30 Dec 2011 21:27:44 +0100 5551732 http://www.medworm.com/index.php?rid=5551731&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22200433%26dopt%3DAbstract Authors: Vaziri ND, Pahl MV, Crum A, Norris K Abstract End-stage renal disease (ESRD) is simultaneously associated with immune activation, marked by systemic inflammation, and immune deficiency. Systemic inflammation contributes to atherosclerosis, cardiovascular disease, cachexia, and anemia, whereas immune deficiency leads to impaired response to vaccination, and increased incidence and severity of microbial infections. ESRD-associated inflammation and immune deficiency are associated with the following: (a) general expansion of monocytes and elevations of their basal integrin, Toll-like receptor (TLR)-2, TLR-4 expression, cytokine production, and reactive oxygen species (ROS) generation and reduced phagocytic capacity, (b) depletion and impaired inhibitory activity of regulatory... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551731 Fri, 30 Dec 2011 21:27:35 +0100 5551731 http://www.medworm.com/index.php?rid=5551730&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22201098%26dopt%3DAbstract Authors: Amano A, Inaba H Abstract Accumulated evidence has strongly suggested that the long-term effects of periodontal diseases can be linked to more serious systemic conditions such as cardiovascular diseases, diabetes, and complications of pregnancy. Especially, a prevalence of coronary heart disease was found to be significantly increased in patients with periodontitis after adjusting for risk factors such as smoking, diabetes, alcohol intake, obesity, and blood pressure. Furthermore, various studies have shown that Porphyromonas gingivalis, a major periodontal pathogen, is able to exacerbate atherosclerosis following oral-hematogenous spread due to the bacteremia. By P. gingivalis, endothelial cells activate and upregulate various adhesion molecules, thus increasing the likel... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551730 Fri, 30 Dec 2011 21:27:27 +0100 5551730 http://www.medworm.com/index.php?rid=5551727&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22201795%26dopt%3DAbstract Authors: Shirwany NA, Zou MH Abstract Diabetes is associated with major life-threatening complications such as a markedly increased risk of cardiovascular disease, even in the presence of rigid glycemic control. Indeed, nearly 75% of diabetic patients eventually die of cardiovascular disease or cardiovascular complications. A striking feature of the diabetic cardiovascular phenotype is the appearance of accelerated atherosclerosis, which resembles atherosclerosis that may be encountered in the non-diabetic individual, except that it is more extensive, aggressive, and occurs at an earlier age. Atherosclerosis (or atherosclerotic vascular disease; ASVD), is a pathological syndrome affecting arterial vessels characterized by narrowing of the vascular lumen secondary to intravascular b... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551727 Fri, 30 Dec 2011 21:27:00 +0100 5551727 http://www.medworm.com/index.php?rid=5551726&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22201863%26dopt%3DAbstract We describe and discuss common, cholesterol-related, molecular mechanisms and strategies to fight these conditions that, altogether, constitute a major cause of death in our societies. PMID: 22201863 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551726 Fri, 30 Dec 2011 21:26:51 +0100 5551726 http://www.medworm.com/index.php?rid=5551725&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22201872%26dopt%3DAbstract Authors: Aboeata AS, Sontineni SP, Alla VM, Esterbrooks DJ Abstract Coronary artery ectasia (CAE) is a well-recognized angiographic finding, characterized by abnormal dilatation of the coronary arteries. We reviewed the current concepts of the condition including etiology, pathogenesis, flow alterations, clinical implications, prognosis and treatment. CAE is often viewed as a variant of obstructive coronary atherosclerosis. Exaggerated positive vascular remodeling due to inflammation, and chronic overstimulation of the endothelium by nitric oxide are potential causative mechanisms. The condition is associated with cardiovascular risk factors such as smoking and hypertension, while it appears to be inversely associated with age and diabetes mellitus. Patients with CAE typically pres... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551725 Fri, 30 Dec 2011 21:26:42 +0100 5551725 http://www.medworm.com/index.php?rid=5551724&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22201906%26dopt%3DAbstract Authors: Emanuele E, Martinelli V, Abbiati V, Ricevuti G Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an important vascular component, ultimately resulting in dementia. Recent years have witnessed an enormous interest in the field of biomarkers in medicine both in the field of atherosclerosis and neurodegeneration. Numerous studies have recently reported altered levels of biomarkers of atherosclerotic vascular disease in patients with AD. This review provides an overview of clinical studies assessing biomarkers of atherosclerosis/vascular disease in the serum/plasma of patients with AD and highlights future directions in the field. The study of specific biomarkers of atherosclerosis in AD can contribute to identify different components of the p... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551724 Fri, 30 Dec 2011 21:26:33 +0100 5551724 http://www.medworm.com/index.php?rid=5551723&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22201964%26dopt%3DAbstract Authors: Lavie L Abstract Obstructive sleep apnea syndrome (OSA) is a breathing disorder in sleep. In recent years, this entity has emerged as a major public health problem due to its high prevalence and the profound impact on patients' health and quality of life. A large body of evidence identified OSA as an independent risk factor for cardiovascular morbidity and mortality. Also an association was demonstrated with additional cardiovascular risk factors. This has led to intensive research on the mechanisms involved. The main characteristics of OSA are the recurrent pauses in respiration which result in intermittent hypoxia (IH) and hypercapnia, accompanied by decreased blood oxygen saturation and arousals during sleep. The associations of OSA with cardiovascular morbidities rely ... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551723 Fri, 30 Dec 2011 21:26:24 +0100 5551723 http://www.medworm.com/index.php?rid=5551722&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202016%26dopt%3DAbstract Authors: Levy P, Tamisier R, Arnaud C, Monneret D, Baguet JP, Stanke-Labesque F, Dematteis M, Godin-Ribuot D, Ribuot C, Pepin JL Abstract Sleep dramatically influences cardiovascular regulation. Changes in sleep duration or quality as seen in sleep disorders may prevent blood pressure to fall during sleep as expected in human physiology. This supports the increased prevalence of hypertension and drug-resistant hypertension in those with sleep loss. Other cardiovascular outcomes i.e. coronary lesions seem to be associated with sleep duration. Systemic inflammation, oxidative stress and endothelial dysfunction seem to be associated with both sleep loss and sleep disorders. The most critical example is Obstructive Sleep Apnea (OSA). Sympathetic activation, oxidative stress and systemi... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551722 Fri, 30 Dec 2011 21:26:15 +0100 5551722 http://www.medworm.com/index.php?rid=5551721&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202050%26dopt%3DAbstract Authors: Vazquez G Abstract Transient Receptor Potential Canonical (TRPC) proteins are non-selective cation channels ubiquitously expressed throughout the cardiovascular system, where they participate as Ca2+/Na+-permeable channels and/or signaling platforms in various physiological and pathophysiological mechanisms. TRPCs have been implicated in essential hypertension, cardiac hypertrophy and endothelial dysfunction. Despite these pathologies being related, directly or indirectly to development of atherosclerotic lesions, the potential role of TRPCs in the pathogenesis of atherosclerosis remains unexplored. Recent studies from our laboratory showing an obligatory requirement of TRPC3 in the inflammatory signaling linked to monocycle recruitment to coronary endothelium, suggest for... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551721 Fri, 30 Dec 2011 21:26:06 +0100 5551721 http://www.medworm.com/index.php?rid=5551720&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202083%26dopt%3DAbstract We present here, recent advances in Nox regulation in the vasculature and discuss novel potential intrinsic feedback mechanisms and current and pharmacological perspectives to target Nox, which may have an impact in vascular health and disease. PMID: 22202083 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551720 Fri, 30 Dec 2011 21:25:58 +0100 5551720 http://www.medworm.com/index.php?rid=5551719&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22202099%26dopt%3DAbstract Authors: Pansuria M, Xi H, Li L, Yang XF, Wang H Abstract Atherosclerosis, a pathological process that underlies the development of cardiovascular disease, is the primary cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). T2DM is characterized by hyperglycemia and insulin resistance (IR), in which target tissues fail to respond to insulin. Systemic IR is associated with impaired insulin signaling in the metabolic tissues and vasculature. Insulin receptor is highly expressed in the liver, muscle, pancreas, and adipose tissue. It is also expressed in vascular cells. It has been suggested that insulin signaling in vascular cells regulates cell proliferation and vascular function. In this review, we discuss the association between IR, metabolic stress, a... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551719 Fri, 30 Dec 2011 21:25:48 +0100 5551719 http://www.medworm.com/index.php?rid=5551734&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22200000%26dopt%3DAbstract CONCLUSIONS: In this large cohort free of clinical cardiovascular disease, several hemostasis and inflammation markers were associated with LV mass. The unusual finding of a negative relationship of CRP and IL6 with LV mass only after adjustment for weight suggests that the effects of inflammation on LV mass are strongly influenced by obesity. PMID: 22200000 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551734 Fri, 30 Dec 2011 21:24:02 +0100 5551734 http://www.medworm.com/index.php?rid=5551733&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22200033%26dopt%3DAbstract Authors: Hofmann Bowman MA, Schmidt AM Abstract Atherosclerosis remains the leading cause of death in the western countries and represents a complex chronic inflammatory process whose regulation is dependent on a network of cytokine and chemokine signaling between key cells such as endothelial cells, monocytes, dendritic cells, lymphocytes and smooth muscle cells. This review focuses on the biology and function of S100 proteins and their receptor RAGE with respect to the multifactorial process leading to atherosclerosis, plaque rupture, and aortic wall remodeling. PMID: 22200033 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551733 Fri, 30 Dec 2011 21:24:02 +0100 5551733 http://www.medworm.com/index.php?rid=5551709&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22206000%26dopt%3DAbstract Authors: Douville JM, Cheung DY, Herbert KL, Moffatt T, Wigle JT Abstract Senescence, the state of permanent cell cycle arrest, has been associated with endothelial cell dysfunction and atherosclerosis. The cyclin dependent kinase inhibitors p21(CIP1/WAF1) and p16(INK4a) govern the G(1)/S cell cycle checkpoint and are essential for determining whether a cell enters into an arrested state. The homeodomain transcription factor MEOX2 is an important regulator of vascular cell proliferation and is a direct transcriptional activator of both p21(CIP1/WAF1) and p16(INK4a). MEOX1 and MEOX2 have been shown to be partially functionally redundant during development, suggesting that they regulate similar target genes in vivo. We compared the ability of MEOX1 and MEOX2 to activate p21(CIP1/WAF1... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551709 Fri, 30 Dec 2011 21:24:02 +0100 5551709 http://www.medworm.com/index.php?rid=5551708&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22206010%26dopt%3DAbstract In conclusion, these findings demonstrate that VEGF-C, rather than VEGF-A, is closely related to dyslipidemia and atherosclerosis. PMID: 22206010 [PubMed - in process] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551708 Fri, 30 Dec 2011 21:24:02 +0100 5551708 http://www.medworm.com/index.php?rid=5551715&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22204330%26dopt%3DAbstract Authors: Nagy Jr B, Miszti-Blasius K, Kerényi A, Clemetson KJ, Kappelmayer J Abstract Cellular interactions among platelets, leukocytes and endothelial cells are considered as a major cause of inflammation and atherosclerosis in many diseases. Via exposed surface receptors and released soluble substances, activated platelets play a crucial role in the initiation of inflammatory processes, resulting in endothelial injury and leading to formation of atherosclerotic plaque with possible thrombotic complications. Classic anti-platelet treatments (e.g. cyclooxygenase inhibitor or ADP-receptor antagonist) have favorable effects in patients with vascular diseases, but they also have several limitations such as increased bleeding risk or non-responsiveness. Thus, the need and opportunitie... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551715 Thu, 29 Dec 2011 05:00:00 +0100 5551715 http://www.medworm.com/index.php?rid=5551713&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205174%26dopt%3DAbstract In this study, high hs-CRP was associated with increased cholesterol and cardiovascular changes supporting the idea that it may be a useful biomarker for detecting early asymptomatic vascular and coronary heart disease resulting from obesity. PMID: 22205174 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551713 Thu, 29 Dec 2011 05:00:00 +0100 5551713 http://www.medworm.com/index.php?rid=5551712&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205244%26dopt%3DAbstract Authors: Williams JK, Andersson KE, Christ G Abstract Erectile dysfunction (ED) is a prevalent medical condition affecting 18 million men and their sexual partners in the United States alone. In the majority of patients, ED is related to alterations in the flow of blood to or from the penis. Undeniably, significant progress has been made in understanding the multifactorial mechanisms that modulate erectile capacity and predispose one to ED, and this, in turn, has led to the availability of more effective treatment options. Nonetheless, all current therapies have untoward side effects, and moreover, there are still no satisfactory treatments for many patients with ED. Further enhancements in the treatment of ED would logically result from both early intervention and more detailed me... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551712 Thu, 29 Dec 2011 05:00:00 +0100 5551712 http://www.medworm.com/index.php?rid=5551710&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205583%26dopt%3DAbstract Authors: Hassan HA, Abdel-Wahhab MA Abstract The aim of the present study was to investigate the cardiac biomarker changes in experimental bilateral ovariectomized (OVX) rats in addition to evaluating the role of soybean oil-supplemented diet to attenuate these alterations. Female rats were divided into four groups and treated for 2 months as follows: groups 1 and 2 fed with standard diet with or without 15% soybean oil. Groups 3 and 4 were bilateral OVX and received the standard diet with or without 15% soybean oil. The results revealed that rats subjected to ovariectomy exhibited an inhibition in estrogen and high-density lipoprotein cholesterol levels and marked increase of lipid profile, low-density lipoprotein cholesterol, and VLDL-C accompanied with a marked elevation in ath... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551710 Thu, 29 Dec 2011 05:00:00 +0100 5551710 http://www.medworm.com/index.php?rid=5551718&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22203234%26dopt%3DAbstract Authors: Boggio A, Muzio F, Fiscella M, Sommariva D, Branchi A Abstract The relationship between overt hypothyroidism and cardiovascular risk has been well documented and some data also suggest an association between cardiovascular risk and subclinical hypothyroidism. The aim of our study was to investigate, in a large cohort of euthyroid women, the association of thyroid stimulating hormone (TSH) within the normal reference range with cardiovascular risk factors. The study was carried out on 744 women with normal thyroid function (TSH 0.3-4.9 μU/mL). Women with TSH above the median (≥2.1 μU/mL) were more obese, had greater waist girth, were more hypertensive and had higher levels of total cholesterol (TC), serum triglycerides (TG), blood sugar (BG) and lower levels of HDL-chol... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551718 Wed, 28 Dec 2011 05:00:00 +0100 5551718 http://www.medworm.com/index.php?rid=5551717&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22203405%26dopt%3DAbstract Authors: Rana JS, Boekholdt SM, Kastelein JJ, Shah PK Abstract Despite aggressive lipid-lowering therapy, patients continue to be at significant risk of coronary heart disease (CHD). Assessment of non-high-density lipoprotein cholesterol (non-HDL-C) provides a measure of cholesterol contained in all atherogenic particles. In the third Adult Treatment Panel (ATP III) guidelines of the US National Cholesterol Education Program, non-HDL-C was introduced as a secondary target of therapy in persons with triglycerides ≥200 mg/dL. A recent meta-analysis of the relationship between non-HDL-C reduction and CHD risk showed non-HDL-C as an important target of therapy for CHD prevention. Most lipid-modifying drugs used as monotherapy have a 1:1 relationship between percent non-HDL-C lowerin... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551717 Wed, 28 Dec 2011 05:00:00 +0100 5551717 http://www.medworm.com/index.php?rid=5551716&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22203486%26dopt%3DAbstract Authors: Ji YN, Wang Q, Zhan P Abstract Coronary atherosclerosis is a leading cause of coronary heart disease (CHD). Atherosclerotic lesion is a complex polygenic disease in which gene-environment interactions play a critical role in disease onset and progression. The ICAM1 gene-E469K polymorphism has been reported to be associated with CHD, but results were conflicting. A systematic review and meta-analysis of the published studies were performed to gain a clearer understanding of this association. The PubMed, Embase, and CNKI databases were searched for case-control studies published up to August 2011. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Twelve eligible studies, comprising 2,157 cases and 1,952 controls, were include... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551716 Wed, 28 Dec 2011 05:00:00 +0100 5551716 http://www.medworm.com/index.php?rid=5551714&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22204493%26dopt%3DAbstract CONCLUSION: Defects in insulin secretion rather than defects in insulin resistance explain the marketed difference in susceptibility to T2DM in the B6.apoE-/- and BALB.apoE-/- mouse model. A smaller islet mass and more prominent islet inflammation may explain the vulnerability of B6.apoE-/- mice to diet-induced diabetes. PMID: 22204493 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551714 Wed, 28 Dec 2011 05:00:00 +0100 5551714 http://www.medworm.com/index.php?rid=5551711&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205309%26dopt%3DAbstract CONCLUSION: The results suggest that the phenolic content of RW may modulate leukocyte adhesion molecules, whereas both ethanol and polyphenols of RW may modulate soluble inflammatory mediators in high-risk patients. The trial was registered in the International Standard Randomized Controlled Trial Number Register at http://www.isrctn.org/ as ISRCTN88720134. PMID: 22205309 [PubMed - as supplied by publisher] (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551711 Wed, 28 Dec 2011 05:00:00 +0100 5551711 http://www.medworm.com/index.php?rid=5551729&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22201674%26dopt%3DAbstract Authors: Rader DJ Abstract Inflammation is a critical component of atherosclerosis. IL-1 is a classic proinflammatory cytokine that has been linked to atherosclerosis. A clinical trial has been launched in which an antibody specific for IL-1β is being studied for its effects on cardiovascular events in patients with atherosclerosis. In this issue of the JCI, Alexander et al. report that mice lacking the receptor for IL-1 unexpectedly have features of advanced atherosclerosis that suggest the atherosclerotic plaques may be less stable. These findings illustrate the complexity of inflammatory pathways in atherosclerosis and suggest the need for careful calibration of antiinflammatory approaches to atherosclerosis. PMID: 22201674 [PubMed - as supplied by publisher] (Source: Ather... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551729 Tue, 27 Dec 2011 05:00:00 +0100 5551729 http://www.medworm.com/index.php?rid=5551728&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22201681%26dopt%3DAbstract Authors: Alexander MR, Moehle CW, Johnson JL, Yang Z, Lee JK, Jackson CL, Owens GK Abstract Clinical complications of atherosclerosis arise primarily as a result of luminal obstruction due to atherosclerotic plaque growth, with inadequate outward vessel remodeling and plaque destabilization leading to rupture. IL-1 is a proinflammatory cytokine that promotes atherogenesis in animal models, but its role in plaque destabilization and outward vessel remodeling is unclear. The studies presented herein show that advanced atherosclerotic plaques in mice lacking both IL-1 receptor type I and apolipoprotein E (Il1r1-/-Apoe-/- mice) unexpectedly exhibited multiple features of plaque instability as compared with those of Il1r1+/+Apoe-/- mice. These features included reduced plaque SMC conten... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5551728 Tue, 27 Dec 2011 05:00:00 +0100 5551728 http://www.medworm.com/index.php?rid=5608538&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010938%2Fabstract%3Frss%3Dyes This article is an expansion of the personal reminiscences given at the time as a tribute to him, and to provide an inside story of how collaboration with such a prominent cardiac pathologist worked. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608538 Mon, 26 Dec 2011 05:00:00 +0100 5608538 http://www.medworm.com/index.php?rid=5608537&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011011105%2Fabstract%3Frss%3Dyes Abstract: Objective: Serum adiponectin protects against incident ischemic heart disease (IHD). However, in patients with existing IHD, higher adiponectin levels are paradoxically associated with worse outcomes. We investigated this paradox by evaluating the relationship between adiponectin and cardiovascular events in patients with existing IHD.Methods: We measured total serum adiponectin and cardiac disease severity by stress echocardiography in 981 outpatients with stable IHD who were recruited for the Heart and Soul Study between September 2000 and December 2002. Subsequent heart failure hospitalizations, myocardial infarction, and death were recorded.Results: During an average of 7.1 years of follow-up, patients with adiponectin levels in the highest quartile were more likely than thos... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608537 Mon, 26 Dec 2011 05:00:00 +0100 5608537 http://www.medworm.com/index.php?rid=5537655&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011011269%2Fabstract%3Frss%3Dyes (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537655 Sun, 25 Dec 2011 02:39:45 +0100 5537655 http://www.medworm.com/index.php?rid=5537607&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS002191501101118X%2Fabstract%3Frss%3Dyes (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537607 Sun, 25 Dec 2011 02:39:29 +0100 5537607 http://www.medworm.com/index.php?rid=5537058&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28%2522Atherosclerosis%2522%29%2520AND%2520%25222011%252F12%252F01%252007.18%2522%255BMHDA%255D%253A%25222011%252F12%252F24%252015.36%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%2522Atherosclerosis%2522%255BTIAB%255D%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F12%252F01%252007.18%2522%255BEDAT%255D%29%29 416 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Atherosclerosis" These pubmed results were generated on 2011/12/24PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537058 Sat, 24 Dec 2011 20:36:06 +0100 5537058 http://www.medworm.com/index.php?rid=5608517&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011011087%2Fabstract%3Frss%3Dyes We examined SNPs at the KIF6 (rs20455 or 719Arg), LPA (rs3798220), TAS2R50 (rs1376251) and VAMP8 (rs1010) in 5,411 participants in PROSPER (PROspective Study of Pravastatin in the Elderly at Risk) (mean age 75.3 years), who had been randomized to pravastatin 40mg/day or placebo and were followed for a mean of 3.2 years. No SNP was related to vascular disease at baseline. Only the KIF6 SNP was related to LDL-C lowering with homozygous Arg 719 subjects being significantly less responsive than other groups (p=0.025, −34.2 vs. −36.1%). With regard to the primary CHD endpoint on trial (fatal or non-fatal myocardial infarction or stroke), we observed a significant relationship for KIF6 719Arg homozygotes (p=0.03, hazards ratio 0.47, 12.8% of the population) in women on pravastatin only, and ... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608517 Fri, 23 Dec 2011 05:00:00 +0100 5608517 http://www.medworm.com/index.php?rid=5608534&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011011002%2Fabstract%3Frss%3Dyes Abstract: Objective: There is debate whether infection with Helicobacter (H.) pylori, the main inducer of chronic atrophic gastritis (CAG), is a risk factor for cardiovascular disease and premature mortality.Methods: Serological measurements of H. pylori infection and pepsinogen (PG) I and II were obtained in a population-based German cohort of 9953 older adults (50–74 years). Cox regression was employed to estimate hazard ratios (HR) and 95% confidence intervals (CI) for myocardial infarction, stroke, cardiovascular and all-cause mortality during five-year follow-up.Results: According to serology, 4977 participants (51.9%) were infected with H. pylori (2604 with cytotoxin-associated gene A (cagA) strains) and 541 (5.7%) had CAG (PGI (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608534 Thu, 22 Dec 2011 05:00:00 +0100 5608534 http://www.medworm.com/index.php?rid=5608532&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010987%2Fabstract%3Frss%3Dyes Conclusion: The Duke, updated Diamond–Forrester, and CORSCORE risk models are most efficient in predicting CAD in a contemporary cohort of patients with symptoms suggestive of angina. The updated Diamond–Forrester may most operational in daily clinical practice since it is calculated from the lowest number of clinical variables. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608532 Thu, 22 Dec 2011 05:00:00 +0100 5608532 http://www.medworm.com/index.php?rid=5608510&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009348%2Fabstract%3Frss%3Dyes We examined associations of single nucleotide polymorphisms (SNPs) at the liver X receptor alpha (LXRA, rs12221497), and the solute carrier organic anion transporter (SLCO1B1, rs4149056 and rs2306283) gene loci with these variables. We studied 5411 participants in PROSPER (PROspective Study of Pravastatin in the Elderly at Risk) (mean age 75.3 years), who had been randomized to pravastatin 40mg/day or placebo and were followed for a mean of 3.2 years. No relationships between genetic variation at the LXRA gene locus with statin induced LDL lowering response or other parameters were noted. Both the SLCO1B1 rs4149056 (valine for alanine at 174) and the rs2306283 (asparagine for aspartic acid at 130) SNPs affect the amino acid sequence of the SLCO1B1 gene product. No effect of the rs2306283 S... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608510 Wed, 21 Dec 2011 05:00:00 +0100 5608510 http://www.medworm.com/index.php?rid=5608536&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011011075%2Fabstract%3Frss%3Dyes Abstract: Objective: Pentraxin 3 (PTX3) is one of the pattern-recognition receptors related to the initial step of the immune response with C-reactive protein, but the physiologic and pathologic functions are not fully understood. The purpose of the current study was to determine the impact of PTX3 levels on mortality after ischemic stroke.Methods: We consecutively enrolled 376 patients who had ischemic stroke between September 2004 and September 2006. The patients were divided into tertiles according to PTX3 levels. Cox regression analysis was used to determine hazard ratios (HRs) and 95% confidence intervals (CIs) of the PTX3 tertiles for all-cause mortality with adjustment for traditional risk factors and laboratory variables, including C-reactive protein.Results: During the follow-up, ... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608536 Mon, 19 Dec 2011 05:00:00 +0100 5608536 http://www.medworm.com/index.php?rid=5608535&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS002191501101104X%2Fabstract%3Frss%3Dyes Abstract: Background: Uric acid is tightly linked to the metabolic syndrome (MetS) and among adults higher uric acid levels are associated with future risk for diabetes, cardiovascular disease, hypertension and renal disease.Objective: Evaluate the sensitivity of MetS to identify adolescents with elevated uric acid levels on a race/ethnicity and gender-specific basis.Methods: We evaluated 3296 male and female adolescents 12–19y participating in the National Health and Nutrition Evaluation Survey 1999–06, comprised of 67.6% non-Hispanic whites, 15.1% non-Hispanic blacks, and 17.3% Hispanics. We used a definition of MetS modified for use in adolescents and evaluated the sensitivity of a diagnosis of MetS to identify individuals with uric acid elevations (approximately the 95th percentile... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608535 Mon, 19 Dec 2011 05:00:00 +0100 5608535 http://www.medworm.com/index.php?rid=5608524&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010653%2Fabstract%3Frss%3Dyes Conclusion: Telomerase activity in leukocytes was associated with calcified atherosclerotic plaque, and was also a predictor of advancing plaque among persons with short telomeres. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608524 Mon, 19 Dec 2011 05:00:00 +0100 5608524 http://www.medworm.com/index.php?rid=5608516&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010860%2Fabstract%3Frss%3Dyes Abstract: Genome-wide association studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The CVD-associated region is adjacent to the two cyclin dependent kinase inhibitors (CDKN)2A and 2B and the last exons of the non-coding RNA, ANRIL. It is still not clear which of or how these transcripts are involved in the pathogenesis of atherosclerosis.Objective: We assessed the hypothesis that 9p21 locus polymorphisms influence the expression of the transcripts in the region (ANRIL, CDKN2A/B) and that these transcripts contribute to atherogenesis through the modulation of proliferation in VSMC.Methods: We genotyped 18 SNPs (r20.05) across the region of interest: CDKN2A/B and ANRIL, encompassing the CVD-associated regio... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608516 Mon, 19 Dec 2011 05:00:00 +0100 5608516 http://www.medworm.com/index.php?rid=5608501&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011011063%2Fabstract%3Frss%3Dyes Conclusion: Our study provides evidence that TAA-associated aortic wall disintegration in BAV and TAV TAAs shows similarities, but also significant differences. BAV and TAV TAAs differ with regard to medial elastic fiber mass and the occurrence of fibroblasts, SMC telomere length, metabolism, and gene expression. This study may form the basis for future in-depth analyses on the relevance of these findings in the pathophysiology of BAV and TAV TAAs. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608501 Mon, 19 Dec 2011 05:00:00 +0100 5608501 http://www.medworm.com/index.php?rid=5608520&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010847%2Fabstract%3Frss%3Dyes Conclusions: These data indicate that arterial stiffness is ameliorated by implementation of longer hemodialysis sessions. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608520 Fri, 16 Dec 2011 05:00:00 +0100 5608520 http://www.medworm.com/index.php?rid=5608505&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010975%2Fabstract%3Frss%3Dyes Conclusions: Taken together our data indicate that PCSK9 secreted by human SMCs is functionally active and capable of reducing LDLR expression in macrophages. A possible direct role for this protein in foam cell formation and atherogenesis is suggested. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608505 Fri, 16 Dec 2011 05:00:00 +0100 5608505 http://www.medworm.com/index.php?rid=5608498&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010665%2Fabstract%3Frss%3Dyes Abstract: Serotonin (5-hydroxytryptamine, 5-HT) plays a crucial role in peripheral artery disease (PAD) and diabetes mellitus (DM). In these conditions, the balance between the 5-HT2A receptor in smooth muscle cells and the 5-HT1B receptor in endothelial cells (ECs) regulates vascular tonus. In the present study, we focused on the role of 5-HT in endothelial dysfunction using a selective 5-HT2A receptor blocker, sarpogrelate.In human EC, 5-HT markedly stimulated eNOS expression and the phosphorylation of eNOS, Akt and ERK1/2. In addition, a dose-dependent increase in tubule-formation on Matrigel was observed after 5-HT treatment. In contrast, high glucose significantly inhibited tubule formation and eNOS expression through inactivation of Akt, while 5-HT significantly attenuated these acti... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608498 Thu, 15 Dec 2011 05:00:00 +0100 5608498 http://www.medworm.com/index.php?rid=5608533&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010999%2Fabstract%3Frss%3Dyes Conclusion: Vitamin D deficiency was highly prevalent in HD patients with marked seasonal variation. However, low 25D levels could not be identified as an independent predictor of vascular calcification in these patients. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608533 Wed, 14 Dec 2011 05:00:00 +0100 5608533 http://www.medworm.com/index.php?rid=5608531&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS002191501101094X%2Fabstract%3Frss%3Dyes Abstract: Objective: Neutrophil gelatinase-associated lipocalin (NGAL) plasma concentrations have been associated with cardiovascular diseases. We aimed to assess the association of NGAL with abdominal aortic aneurysm (AAA).Methods: NGAL concentrations were analyzed by Western blotting in conditioned medium of polymorphonuclear neutrophils (PMNs) from AAA patients (n=22) and controls (n=11), and also in aortic biopsies from AAA patients and healthy controls (n=10). Plasma NGAL concentrations were measured by ELISA in three groups of subjects from France (n=60), Spain (n=75) and Australia (n=100) and associated with AAA presence and growth.Results: PMNs isolated from AAA patients secreted significantly greater amounts of NGAL than PMNs from controls. Luminal thrombus released large amounts ... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608531 Wed, 14 Dec 2011 05:00:00 +0100 5608531 http://www.medworm.com/index.php?rid=5608519&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010197%2Fabstract%3Frss%3Dyes Conclusion: PPAR-δ and statin therapies have complementary effects in improving lipoprotein subfractions associated with atherogenic dyslipidemia. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608519 Wed, 14 Dec 2011 05:00:00 +0100 5608519 http://www.medworm.com/index.php?rid=5608503&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010756%2Fabstract%3Frss%3Dyes Conclusions: Trans-resveratrol up-regulated hepatic LDLR expression via proteolytic activation of SREBPs. We concluded that trans-resveratrol exhibits the anti-atherogenic effect, at least in part, by increased hepatic LDLR expression and subsequent LDL uptake. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608503 Mon, 12 Dec 2011 05:00:00 +0100 5608503 http://www.medworm.com/index.php?rid=5608530&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010926%2Fabstract%3Frss%3Dyes Conclusion: In both atherosclerotic phenotypes, serum PON3 concentration was increased, but this was associated with decreased insulin sensitivity in PAD and with inflammation in CAD. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608530 Fri, 09 Dec 2011 05:00:00 +0100 5608530 http://www.medworm.com/index.php?rid=5608529&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010872%2Fabstract%3Frss%3Dyes Abstract: Background: Omega-3 fatty acids and fenofibrate are both used to treat patients with hypertriglyceridemia. However, a head-to-head comparison of the lipoprotein and metabolic effects of these two medicines has not been published.Methods: This was a randomized, single-blind, placebo-controlled, parallel study. Age, sex, and body mass index were matched among groups. All patients were recommended to maintain a low fat diet. Fifty patients in each group were given placebo, omega-3 fatty acids 2g (most commonly used dosage in Korean patients), or fenofibrate 160mg, respectively daily for 2 months.Results: Omega-3 fatty acids therapy decreased triglycerides by 21% and triglycerides/HDL cholesterol and improved flow-mediated dilation (P (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608529 Fri, 09 Dec 2011 05:00:00 +0100 5608529 http://www.medworm.com/index.php?rid=5608515&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS002191501101080X%2Fabstract%3Frss%3Dyes In this study we tested the hypothesis that the NOS1 and NOS3 genes, respectively encoding neuronal NOS (nNOS) and endothelial NOS (eNOS), influence stroke susceptibility and outcome after a stroke event.Methods: We conducted a case–control association study in 551 ischemic stroke patients and 530 controls to assess the role of NOS1 and NOS3 variants in stroke susceptibility. The same genes were tested for association with stroke outcome in a subset of 431 patients.Results: Four NOS1 single nucleotide polymorphisms (SNPs) (rs2293050, rs2139733, rs7308402 and rs1483757) and four haplotypes were significantly associated with stroke susceptibility after adjusting for demographic, clinical and life-style risk factors, and correcting for multiple testing using the false discovery rate (FDR) m... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608515 Fri, 09 Dec 2011 05:00:00 +0100 5608515 http://www.medworm.com/index.php?rid=5608504&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010823%2Fabstract%3Frss%3Dyes Conclusions: Whole body RAP deficiency attenuated atherosclerosis without influencing AAAs in hypercholesterolemic mice infused with AngII. The anti-atherogenic effect was not attributable to RAP deficiency in bone marrow-derived cells. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608504 Fri, 09 Dec 2011 05:00:00 +0100 5608504 http://www.medworm.com/index.php?rid=5537608&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010732%2Fabstract%3Frss%3Dyes 2011 has been another excellent year for the Journal. In 2010 we received 1527 submitted manuscripts, and based on current projections this number will be up by at least 7% in 2011. The largest number of papers accepted were again from the US (17% papers), Japan (11%) and Italy (8%) but over the last year we have accepted papers from 41 different countries worldwide, demonstrating the truly international nature of the journal and its readership. We are still maintaining a high rejection rate, with 70% of clinical investigations and 59% of basic research investigations being rejected. While no-one likes to have their paper rejected, the mission of the Editorial team is to accept only the very best papers and we believe we are continuing to achieve this goal. As an indicator of this, the onl... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537608 Fri, 09 Dec 2011 05:00:00 +0100 5537608 http://www.medworm.com/index.php?rid=5608528&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010859%2Fabstract%3Frss%3Dyes Conclusions: Significant changes in Lp-PLA2 concentrations occur early after stroke onset. Lp-PLA2 mass may add relevant information regarding early arterial recanalization in intravenous t-PA-treated stroke patients. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608528 Thu, 08 Dec 2011 05:00:00 +0100 5608528 http://www.medworm.com/index.php?rid=5608527&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010835%2Fabstract%3Frss%3Dyes Abstract: Objective: Despite some epidemiologic research demonstrating a positive relationship between serum uric acid (SUA) levels and the prevalence of metabolic syndrome (MetS), prospective data on SUA as a predictor of MetS incidence are limited.Methods: The authors examined SUA as a risk marker for incident MetS in a prospective study of 3857 subjects who were free of MetS at baseline recruitment. Hyperuricemia was defined as SUA ≥7.7mg/dL for men and ≥6.6mg/dL for women. The MetS was defined according to a unified criteria set by several major organizations.Results: During a mean follow-up of 5.41 years, 476 participants developed MetS. A significantly stepwise increase in the incidence of MetS across tertiles of SUA was observed in the whole group (p for trend (Source: Atheroscl... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608527 Thu, 08 Dec 2011 05:00:00 +0100 5608527 http://www.medworm.com/index.php?rid=5608526&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010811%2Fabstract%3Frss%3Dyes Conclusions: Low-grade inflammation may be associated with a serum fatty acid pattern of high palmitic acid or low alpha-linolenic acid in men, and of high dihomo-gamma-linolenic acid or low delta-5-desaturase in both sexes. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608526 Thu, 08 Dec 2011 05:00:00 +0100 5608526 http://www.medworm.com/index.php?rid=5608499&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010719%2Fabstract%3Frss%3Dyes Conclusion: HRSS may have a protective role in the prevention of neointima hyperplasia and restenosis after angioplasty. HRSS may partially exert its role by neutralizing the local ROS and suppressing the TNF-α/NF-κB pathway. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608499 Wed, 07 Dec 2011 05:00:00 +0100 5608499 http://www.medworm.com/index.php?rid=5608525&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010768%2Fabstract%3Frss%3Dyes Abstract: Objective: Chronic inflammation plays a role in the pathogenesis of metabolic syndrome (MetS) and cardiovascular disease (CVD). Complement component 3 (C3) is a novel cardiometabolic risk factor. Whether dietary fat intake modulates MetS risk conferred by elevated C3 concentrations is unknown. Our objective is to investigate the relationship between C3 concentrations and risk of the MetS and its phenotypes, and to further examine whether dietary fat intake modulates these relationships.Methods: Biochemical, dietary and lifestyle measurements were determined in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n=1754).Results: Elevated C3 concentrations (>median) were associated with increased risk of impaired insulin sensitivity [OR 1.78, CI 1.34–2.36, P (Source: ... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608525 Tue, 06 Dec 2011 05:00:00 +0100 5608525 http://www.medworm.com/index.php?rid=5608514&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010793%2Fabstract%3Frss%3Dyes Conclusions: It is likely that the G allele of the ADIPOQ G276T polymorphism is a susceptibility allele for CVD in Japanese type 2 diabetic patients, especially when they accompany obesity. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608514 Tue, 06 Dec 2011 05:00:00 +0100 5608514 http://www.medworm.com/index.php?rid=5608509&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010781%2Fabstract%3Frss%3Dyes Abstract: Objective: Low Ankle-Brachial Blood Pressure Index (ABI) identifies patients with symptomatic and asymptomatic peripheral arterial disease (PAD). We sought to investigate the association of low ABI with early risk of stroke recurrence in patients with acute cerebral ischemia (ACI) and without history of symptomatic PAD.Methods: Consecutive patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA) and no previous history of PAD were prospectively evaluated with ABI measurements. Demographic characteristics, vascular risk factors and secondary prevention therapies were documented. An ABI ≤0.90 in either leg was considered as evidence of asymptomatic PAD, and an ABI >0.90 was considered as normal. Patients with elevated ABI (>1.30) were excluded. The outcome of ... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608509 Mon, 05 Dec 2011 05:00:00 +0100 5608509 http://www.medworm.com/index.php?rid=5608508&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS002191501101077X%2Fabstract%3Frss%3Dyes Conclusions: Circulating sRAGE showed significant association with TBR values measured using FDG-PET, which reflect vascular inflammation. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608508 Mon, 05 Dec 2011 05:00:00 +0100 5608508 http://www.medworm.com/index.php?rid=5608507&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010240%2Fabstract%3Frss%3Dyes Conclusion: The endogenous multispectral FLIM approach we have taken, which can readily be adapted for in vivo intravascular catheter based imaging, is capable of reliably identifying plaques with high content of either collagen or lipids. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608507 Mon, 05 Dec 2011 05:00:00 +0100 5608507 http://www.medworm.com/index.php?rid=5608512&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010641%2Fabstract%3Frss%3Dyes Conclusion: A genetic predisposition to up-regulation of LT mediators is unlikely to play a dominant role in the pathogenesis of AAA. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608512 Fri, 02 Dec 2011 05:00:00 +0100 5608512 http://www.medworm.com/index.php?rid=5608511&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010264%2Fabstract%3Frss%3Dyes This study was designed to perceive the possible role of epistasis in the etiology of essential hypertension.Methods: We investigated seven polymorphisms of ACE, CYP11B2 and NOS3 epistatically, and SBP, DBP, MAP, ACE activity, plasma aldosterone concentration (PAC) and NOx level in 860 age- and ethnicity-matched unrelated north-Indian subjects.Results: The hypertension risk in individuals with interacted-genotypes (IwIw+IwIc)+(4aa), (IcIc)+(4bb+4ba) and IcIc+4aa of the CYP11B2 and NOS3 was significantly higher with odds ratio 5.5 (95% CI=2.9–10.6, P (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608511 Fri, 02 Dec 2011 05:00:00 +0100 5608511 http://www.medworm.com/index.php?rid=5459216&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28%2522Atherosclerosis%2522%29%2520AND%2520%25222011%252F11%252F19%252015.00%2522%255BMHDA%255D%253A%25222011%252F12%252F01%252007.18%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%2522Atherosclerosis%2522%255BTIAB%255D%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F11%252F19%252015.00%2522%255BEDAT%255D%29%29 166 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Atherosclerosis" These pubmed results were generated on 2011/12/01PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5459216 Thu, 01 Dec 2011 12:18:02 +0100 5459216 http://www.medworm.com/index.php?rid=5457287&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010331%2Fabstract%3Frss%3Dyes (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5457287 Thu, 01 Dec 2011 02:36:34 +0100 5457287 http://www.medworm.com/index.php?rid=5608513&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010707%2Fabstract%3Frss%3Dyes We describe a mutation in LDLR of two unrelated Arab families. We investigated 19 patients using DNA sequencing, RFLP, and real-time (RT) PCR. DNA sequencing showed a base pair substitution (c.1706-2 A>T) in the splice acceptor site of LDLR intron 11. Our results were confirmed by RFLP on 2% agarose gel. In silico analysis predicted a new cryptic splice site downstream of the original position generating a 10-base deletion from the beginning of exon 12; (c.1706-1715del.ATCTCCTCAG). cDNA sequencing of exon 12 confirmed the computational analysis. The deletion was visualized on 4% agarose gel. The deletion generates a frameshift and a premature termination codon (c.1991-1993; p.(Asp569Valfs*93). RT-PCR revealed that LDLR mRNA is 9.3%±6.5 and 17.9%±8.0 for FH homozygote and heterozygote ind... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608513 Wed, 30 Nov 2011 05:00:00 +0100 5608513 http://www.medworm.com/index.php?rid=5608523&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS002191501101063X%2Fabstract%3Frss%3Dyes Conclusion: Elevated levels of suPAR are, independently of established cardiovascular risk factors, associated with an increased incidence of CVD in elderly subjects. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608523 Mon, 28 Nov 2011 05:00:00 +0100 5608523 http://www.medworm.com/index.php?rid=5608522&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010288%2Fabstract%3Frss%3Dyes Conclusions: High oxHDL, particularly with concomitant high IL-6, may be associated with an increased risk of CVD events and CVD-related mortality in prevalent HD patients. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608522 Mon, 28 Nov 2011 05:00:00 +0100 5608522 http://www.medworm.com/index.php?rid=5608500&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010720%2Fabstract%3Frss%3Dyes In this study, we found that mean plasma fibrinogen level was approximately 10-fold higher in MMP12 knockout mice than wildtype mice (p=0.0006). Differential allelic expression analysis of human MMP12 gene polymorphism rs17368582 in human vascular tissues showed an allele-specific effect on MMP12 expression, with one allele (T) having 1.6 fold higher expression level than the other allele (C) (p=0.0006). In a population cohort, we found that individuals homozygous for the MMP12 low expression allele had higher plasma fibrinogen levels (2.95mg/mL compared with 2.61mg/mL in other individuals, p=0.029) and increased risk of advanced atherosclerosis [odds ratio 6.3 (95% CI 1.9–20.8), p=0.003] and myocardial infarction [hazard ratio 5.6 (95% CI 1.7–18.3), p=0.005]. In summary, our study in ... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608500 Mon, 28 Nov 2011 05:00:00 +0100 5608500 http://www.medworm.com/index.php?rid=5537629&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010033%2Fabstract%3Frss%3Dyes Abstract: Background: The previous OLIVUS trial reported a positive role in achieving a lower rate of coronary atheroma progression through the administration of Olmesartan, an angiotension-II receptor blocking agent (ARB), for stable angina pectoris (SAP) patients requiring percutaneous coronary intervention (PCI). However, the benefits between ARB administration on long-term clinical outcomes and serial atheroma changes by IVUS remain unclear. Thus, we examined the 4-year clinical outcomes from OLIVUS according to treatment strategy with Olmesartan.Methods: Serial volumetric IVUS examinations (baseline and 14 months) were performed in 247 patients with hypertension and SAP. When these patients underwent PCI for culprit lesions, IVUS was performed in their non-culprit vessels. Patients we... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537629 Mon, 28 Nov 2011 05:00:00 +0100 5537629 http://www.medworm.com/index.php?rid=5537639&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010677%2Fabstract%3Frss%3Dyes Abstract: Objective: The effectiveness of the cholesterol absorption inhibitor ezetimibe on LDL subfractions and ultimately on the atherosclerotic risk profile remains controversial. We thus determined the concentration of atherogenic small, dense LDL (sdLDL) in patients with type 2 diabetes and an elevated cardiovascular risk profile.Research design and methods: Multicenter, randomized, open-label 6-week study investigating the effect of ezetimibe 10mg (E), simvastatin 20mg (S) and the combination of ezetimibe-/simvastatin 10/20mg (C) on the concentration of sdLDL separated from fresh plasma by gradient ultracentrifugation in patients with type 2 diabetes (NCT01384058).Results: Fifty-six patients were screened for sdLDL, 41 were randomized, and 40 patients (12 E, 14 S and 14 C) completed ... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537639 Thu, 24 Nov 2011 05:00:00 +0100 5537639 http://www.medworm.com/index.php?rid=5537623&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010124%2Fabstract%3Frss%3Dyes Conclusions: This study not only reveals several dysregulated genes in human lesions but also focuses the role played by the genes involved in the eicosanoid synthesis pathway during atherosclerotic development. The decrease of PTGIS and PTGIR expression after oxLDL treatment mirrors the decreased mRNA levels in atherosclerotic lesions versus control arteries, which suggests that oxidation is important for PTGIS and PTGIR regulation in human vessel cells during atherosclerosis development. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537623 Wed, 23 Nov 2011 05:00:00 +0100 5537623 http://www.medworm.com/index.php?rid=5608495&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010148%2Fabstract%3Frss%3Dyes In the last year, pooled analysis of Genome Wide Association Studies (GWAS) for coronary heart disease (CHD) risk have increased the number of CHD risk loci to 23. Some of these were GWAS identified novel loci, while others, such as LDLR and PCSK9, were previously studied candidate genes, which were subsequently confirmed by GWAS . For all the SNPs the odds ratios for CHD risk were modest, ranging from 1.51 (LPA) to 1.06 (UBE2Z, GIP, ATP5G1 and SNF8), confirming the polygenic nature of CHD. Interestingly APOE is not amongst these 23 genes, despite meta-analysis reporting of APOE CHD risk association . One explanation for this could be the poor coverage on the GWAS arrays of the two SNPs that determine APOE genotype, ɛ2, ɛ3 and ɛ4. However, complex diseases, such as CHD, are multifactori... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608495 Mon, 21 Nov 2011 05:00:00 +0100 5608495 http://www.medworm.com/index.php?rid=5537654&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010252%2Fabstract%3Frss%3Dyes Conclusion: This study suggests an involvement of p66Shc in the transition of a stable CAD to an ACS patient. p66Shc was associated with states of increased oxidative stress. Further work is needed to understand whether p66Shc may represent a possible pharmacological target or whether it represents an interesting novel biomarker. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537654 Mon, 21 Nov 2011 05:00:00 +0100 5537654 http://www.medworm.com/index.php?rid=5537653&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010215%2Fabstract%3Frss%3Dyes Conclusions: Our findings suggest that hsCRP predicts the risk of MetS, independent of obesity and insulin resistance, and therefore, can be a valuable tool to aid the identification of individuals at risk of MetS. The study provides a lead for future investigation for effects of hsCRP, obesity, and insulin resistance on MetS in this population. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537653 Mon, 21 Nov 2011 05:00:00 +0100 5537653 http://www.medworm.com/index.php?rid=5537633&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010239%2Fabstract%3Frss%3Dyes Abstract: Objective: Recent studies make remarks on the effect of variability in systolic blood pressure (SBP) on the development of cardiovascular disease. The aim of this study was to investigate the relationship between the variability in SBP and the degree of diabetic nephropathy and atherosclerosis in patients with type 2 diabetes.Methods: We measured SBP in 422 consecutive patients with type 2 diabetes at every visit during a year, and we calculated the coefficient of variation (CV) of SBP. Then, we evaluated relationships of variability of SBP to degree of urinary albumin excretion (UAE), which is a useful marker for cardiovascular disease as well as diabetic nephropathy, ankle-brachial index (ABI) and pulse wave velocity (PWV).Results: CV of SBP positively correlated with logUAE (r... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537633 Mon, 21 Nov 2011 05:00:00 +0100 5537633 http://www.medworm.com/index.php?rid=5537627&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010161%2Fabstract%3Frss%3Dyes Conclusion: It is suggested that the postulated difference in EAT volume between CAD patients and non-CAD patients is not caused by a differential mRNA expression of fat mobilizing genes. Further work on protein levels and enzyme activities will be necessary to get a complete picture. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537627 Mon, 21 Nov 2011 05:00:00 +0100 5537627 http://www.medworm.com/index.php?rid=5537626&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS002191501101015X%2Fabstract%3Frss%3Dyes Conclusion: This is the first report that echium oil is anti-atherogenic, suggesting that it may be a botanical alternative to fish oil for atheroprotection. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537626 Mon, 21 Nov 2011 05:00:00 +0100 5537626 http://www.medworm.com/index.php?rid=5537624&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010227%2Fabstract%3Frss%3Dyes Conclusions: Our results demonstrate that IGFBP-1 mRNA and protein is detected at increased levels in human carotid plaques, possibly as a consequence of plaque inflammation. IGFBP-1 affects SMC proliferation and may be involved in the regulation of plaque stability. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537624 Mon, 21 Nov 2011 05:00:00 +0100 5537624 http://www.medworm.com/index.php?rid=5424525&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28%2522Atherosclerosis%2522%29%2520AND%2520%25222011%252F11%252F07%252012.15%2522%255BMHDA%255D%253A%25222011%252F11%252F19%252015.00%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%2522Atherosclerosis%2522%255BTIAB%255D%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F11%252F07%252012.15%2522%255BEDAT%255D%29%29 209 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Atherosclerosis" These pubmed results were generated on 2011/11/19PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5424525 Sat, 19 Nov 2011 20:00:02 +0100 5424525 http://www.medworm.com/index.php?rid=5537634&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010276%2Fabstract%3Frss%3Dyes Abstract: Background: Low ankle–brachial index (ABI) is associated with increased risk of subsequent cardiovascular disease events, independent of Framingham risk factors, but its ability to improve risk prediction prospectively has not been examined.Methods: We conducted post-hoc analysis of data from Atherosclerosis Risk in Communities Study (ARIC Study), a large prospective cohort study. 11,594 white and African American (24.2%) men and women, aged 45–64 years, with available Framingham Risk Score (FRS) variables and ABIs at baseline, and without known history of cardiovascular disease or diabetes mellitus or known peripheral arterial disease at baseline were assessed for hard cardiovascular events (hCVD; defined as heart attack, coronary death or stroke) over median follow-up of 10... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537634 Fri, 18 Nov 2011 05:00:00 +0100 5537634 http://www.medworm.com/index.php?rid=5537632&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010185%2Fabstract%3Frss%3Dyes Abstract: Ischemic conditioning has long held promise for preventing ischemic–reperfusion (I–R) injury. Although a number of studies have evaluated the effects of brief repeated episodes of ischemia before a prolonged ischemic episode on the cardiovascular system using clinical endpoints, more sensitive techniques by which to measure its effects are lacking. Since endothelial function is sensitive to I–R injury, flow mediated dilation of the brachial artery has been proposed for this purpose, but has significant limitations. Hyperemia normally decreases carotid to radial pulse wave velocity (PWV). Accordingly, we sought to determine the effects of I–R injury and ischemic conditioning on the hyperemic change (Δ) in PWV. We induced hyperemia by release of arterial cuff occlusion bef... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537632 Fri, 18 Nov 2011 05:00:00 +0100 5537632 http://www.medworm.com/index.php?rid=5537615&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009488%2Fabstract%3Frss%3Dyes The first joint ESC/EAS guidelines for the management of dyslipidemia were recently published in Atherosclerosis and the European Heart Journal. The guidelines were also a major highlight of EAS 2011 Gothenburg. The key points of the guidelines are summarised below. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537615 Fri, 18 Nov 2011 05:00:00 +0100 5537615 http://www.medworm.com/index.php?rid=5537631&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010057%2Fabstract%3Frss%3Dyes We examined the extent to which lower quantities of these circulating angiogenic cell phenotypes may be related to impaired vascular function and greater arterial stiffness.Methods: We studied 1948 Framingham Heart Study participants (mean age, 66±9 years; 54% women) who were phenotyped for circulating angiogenic cells: CD34+, CD34+/KDR+, and early outgrowth colony forming units (CFU). Participants underwent non-invasive assessments of vascular function including peripheral arterial tone (PAT), arterial tonometry, and brachial reactivity testing.Results: In unadjusted analyses, higher CD34+ and CD34+/KDR+ concentrations were modestly associated with lower PAT ratio (β=−0.052±0.011, P (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537631 Thu, 17 Nov 2011 05:00:00 +0100 5537631 http://www.medworm.com/index.php?rid=5608496&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009981%2Fabstract%3Frss%3Dyes Cholesteryl ester transfer protein (CETP) inhibition has been a ‘hot topic’ in recent news. At the European Society of Cardiology (ESC) Congress in Paris 27–31 August, two trials with dalcetrapib were presented – dal-PLAQUE and dal-VESSEL. Results and implications from these trials are discussed here. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608496 Mon, 14 Nov 2011 05:00:00 +0100 5608496 http://www.medworm.com/index.php?rid=5537652&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010203%2Fabstract%3Frss%3Dyes In this study, we performed longitudinal and cross-sectional studies in healthy children and adolescents to investigate age- and sex-related differences in vascular functions and vascular response to mental stress.Methods: Pulse wave velocity (PWV) was measured by tonometry. Endothelial function and vascular response to mental arithmetic test were assessed using a peripheral artery tonometry device. Data were obtained in 162 adolescents (mean age of 17 years, 94 girls) in a 3-year follow-up study and 241 children (mean age of 10 years, 115 girls) in a first-time investigation. Physical activity was assessed in adolescents by a self-report questionnaire.Results: Our 3-year follow-up study revealed that the increased PWV was greater in male adolescents (0.79±0.79m/s) than in females (0.27±... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537652 Mon, 14 Nov 2011 05:00:00 +0100 5537652 http://www.medworm.com/index.php?rid=5537622&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010112%2Fabstract%3Frss%3Dyes Conclusion: C1inh significantly protects against early vein graft remodeling, including loss of endothelium and intimal thickening. These data suggest that it may be worth considering its use in patients undergoing coronary artery bypass grafting. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537622 Mon, 14 Nov 2011 05:00:00 +0100 5537622 http://www.medworm.com/index.php?rid=5537621&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010100%2Fabstract%3Frss%3Dyes Conclusions: The plaque formation in the arch of apoE-null mice is accompanied by strain-dependent changes in both arch geometry and hemodynamics. While arch plaque sizes negatively correlate with mean rWSS, additional factors are necessary to account for the strain differences in arch plaque development. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537621 Mon, 14 Nov 2011 05:00:00 +0100 5537621 http://www.medworm.com/index.php?rid=5457385&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011008252%2Fabstract%3Frss%3Dyes Conclusion: PDSA but not habitual snoring was associated with high incident CV events and all-cause mortality in a multi-ethnic population based study of adults free of clinical CV disease at baseline. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5457385 Fri, 11 Nov 2011 05:00:00 +0100 5457385 http://www.medworm.com/index.php?rid=5457295&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011005934%2Fabstract%3Frss%3Dyes Two recent studies focus on anti-thrombotic effects of n-3 fatty acids, from marine or plant-derived sources. The first, in the clinical setting of stable coronary artery disease patients undergoing percutaneous coronary intervention (PCI), show that adding n-3 fatty acids (1g/day) to standard therapy improves clot properties and decreases thrombin formation. These actions may contribute to a decrease in thrombotic effects in patients . (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5457295 Fri, 11 Nov 2011 05:00:00 +0100 5457295 http://www.medworm.com/index.php?rid=5608521&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS002191501101001X%2Fabstract%3Frss%3Dyes Conclusion: The APOE ɛ2 allele counteracted CHD risk from smoking in both genders, while the ɛ4 allele was seen to potentiate this risk mainly in women. Similar ɛ2 protection and ɛ4 potentiation was suggested for CHD risk from physical inactivity. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608521 Wed, 09 Nov 2011 05:00:00 +0100 5608521 http://www.medworm.com/index.php?rid=5537651&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010136%2Fabstract%3Frss%3Dyes Conclusion: This is the first demonstration of an association of vitamin D deficiency with abnormal vascular endothelial function in non-dialysis CKD patients. Further studies with intervention and exploration of the mechanism are needed to establish a cause effect relationship. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537651 Wed, 09 Nov 2011 05:00:00 +0100 5537651 http://www.medworm.com/index.php?rid=5537635&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011003492%2Fabstract%3Frss%3Dyes Conclusions: The homozygous CYP2C19*2/*2 genotype is an independent determinant of adverse vascular events in Chinese patients with CAD. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537635 Wed, 09 Nov 2011 05:00:00 +0100 5537635 http://www.medworm.com/index.php?rid=5382283&cid=s_34525_7_f&fid=33882&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%28%28%2522Atherosclerosis%2522%29%2520AND%2520%25222011%252F10%252F09%252023.04%2522%255BMHDA%255D%253A%25222011%252F11%252F07%252012.15%2522%255BMHDA%255D%29%29%2520NOT%2520%28%28%2520%28%28%2522Atherosclerosis%2522%255BTIAB%255D%29%29%2520AND%2520%25220001%2522%255BEDAT%255D%253A%25222011%252F10%252F09%252023.04%2522%255BEDAT%255D%29%29 445 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Atherosclerosis" These pubmed results were generated on 2011/11/07PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5382283 Mon, 07 Nov 2011 17:15:01 +0100 5382283 http://www.medworm.com/index.php?rid=5608497&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009567%2Fabstract%3Frss%3Dyes Abstract: Objective: Recent studies indicate that regulatory T cells (Tregs) attenuate murine atherosclerosis. Since interleukin (IL)-2 induces Tregs proliferation, we tested the impact of L19-IL2, a fusion antibody specific to extra-domain B of fibronectin (ED-B) containing an active human IL-2 molecule, in experimental atherosclerosis.Methods and results: L19-IL2 or appropriate controls were given intravenously to 6 month old Western diet-fed apoE−/− mice on day 1, 3, and 5. Human IL-2 was detected on day 7 within atherosclerotic plaques of L19-IL2-treated mice, and magnetic resonance imaging of the plaques showed a significant adventitial gadolinium enhancement on day 7 and 13, suggesting microvascular leakage as a result of the pharmacodynamic activity of L19-IL2. Treatment with L1... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5608497 Mon, 07 Nov 2011 05:00:00 +0100 5608497 http://www.medworm.com/index.php?rid=5537650&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010070%2Fabstract%3Frss%3Dyes Abstract: Aim: Recently, the concept that high density lipoprotein (HDL) quality is an important parameter for atheroprotection is gaining ground, though little data exists so far to support it. In an attempt to identify measurable qualitative parameters of HDL associated with increased risk for premature myocardial infarction (MI), we studied the structural characteristics of HDL from patients who survived an MI at a young age (≤35 years).Methods and results: We studied 20 MI patients and 20 healthy control subjects. HDL of patients had reduced apolipoprotein A-I (apoA-I), apolipoprotein M, and paraoxonase 1 levels and significantly elevated apolipoprotein C-III (apoCIII) levels (all p (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537650 Mon, 07 Nov 2011 05:00:00 +0100 5537650 http://www.medworm.com/index.php?rid=5537649&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009993%2Fabstract%3Frss%3Dyes Conclusions: HDL is a strong predictor of long term risk of CHD, fatal CHD and fatal CVD in healthy middle-aged men. Physical fitness or its changes had no impact on the ability of HDL to predict CHD. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537649 Mon, 07 Nov 2011 05:00:00 +0100 5537649 http://www.medworm.com/index.php?rid=5537648&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009920%2Fabstract%3Frss%3Dyes Conclusions: An increase in plasma CXCL16 during the first days after the initial event is associated with an adverse outcome in patients with acute ischemic stroke, supporting the potential pathogenic role of CXCL16 in atherosclerosis and vascular remodelling as well as their major clinical consequences. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537648 Mon, 07 Nov 2011 05:00:00 +0100 5537648 http://www.medworm.com/index.php?rid=5537636&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010094%2Fabstract%3Frss%3Dyes Conclusion: In patients with stable coronary artery disease the CRP 1444TT and CD14 260TT variants are associated with larger coronary plaque volume independently of concomitant cardiovascular risk factors. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537636 Mon, 07 Nov 2011 05:00:00 +0100 5537636 http://www.medworm.com/index.php?rid=5537630&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010045%2Fabstract%3Frss%3Dyes Abstract: Introduction: Epicardial fat volume (EFV) is linked to cardiovascular event risk. We aimed to investigate the relationships between EFV and weight change.Methods: From the EISNER (Early Identification of Subclinical Atherosclerosis using Non-invasive Imaging Research) Registry with baseline and follow-up coronary calcium scans (1248 subjects), we selected a cohort of 374 asymptomatic subjects matched using age decade, gender and coronary calcium score (CCS) as a measure of subclinical cardiovascular risk, who underwent 2 scans at an interval of 4.1±0.4 years. Using semi-automated validated software, pericardial contours were generated on all slices by spline interpolation from 5 to 10 control points. EFV was computed as fat volume within the pericardial contours. Weight gain/los... Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537630 Mon, 07 Nov 2011 05:00:00 +0100 5537630 http://www.medworm.com/index.php?rid=5537618&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009907%2Fabstract%3Frss%3Dyes Conclusion: Poly-IgM treatment reduced aortic and accelerated carotid atherosclerosis in apoE−/− mice in association with increased anti-oxLDL IgG titers, and reduced number and proliferative function of splenic CD4+ T cells. Our study identifies a novel athero-protective and immunomodulatory role for non-immune polyclonal IgM. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537618 Mon, 07 Nov 2011 05:00:00 +0100 5537618 http://www.medworm.com/index.php?rid=5457303&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011008392%2Fabstract%3Frss%3Dyes Conclusions: The two mouse models develop aortic calcification in an age- and diet-dependent manner. Abnormal regulation of the LRP5/Wnt pathway may play a role in the calcification process. Further analysis of these aortic calcification models using this micro-CT imaging technique may provide a better understanding of the link between FH and arterial calcification. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5457303 Thu, 03 Nov 2011 04:00:00 +0100 5457303 http://www.medworm.com/index.php?rid=5386128&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011005107%2Fabstract%3Frss%3Dyes Obesity is a major health issue affecting both developed and developing countries. In Europe, it is estimated that about one-third of coronary heart disease (CHD) and ischaemic stroke and almost 60% of hypertensive disease are attributed to increased body mass index (BMI) . The increasing prevalence of obesity among children adolescents across the region – and globally – is a major cause of concern . In spite of efforts aimed at increasing awareness and preventive measures, prevalence increases to rise. Studies showing that the emergence of atherosclerotic disease can occur early in life, with children displaying fatty streaks in their arteries, underscore the need for an early preventive approach to address this problem. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5386128 Tue, 01 Nov 2011 04:00:00 +0100 5386128 http://www.medworm.com/index.php?rid=5386120&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009634%2Fabstract%3Frss%3Dyes (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5386120 Tue, 01 Nov 2011 04:00:00 +0100 5386120 http://www.medworm.com/index.php?rid=5537644&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009427%2Fabstract%3Frss%3Dyes Abstract: Objective: Stress and heart failure are associated with increased systemic levels of chromogranin A (CGA). Here we analyzed the effects of marathon running on systemic CGA levels and the association with cardiac burden and stress.Methods: We recruited 47 lean and obese runners for a 10week training program aiming at running a marathon. Heart rates, individual fitness and marathon finishing times were monitored. CGA, proBNP and troponin T levels were analyzed by ELISA.Results: We found a significant increase of CGA (+51%; p (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537644 Mon, 31 Oct 2011 04:00:00 +0100 5537644 http://www.medworm.com/index.php?rid=5537643&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009415%2Fabstract%3Frss%3Dyes Abstract: Objective: Endogenous thrombin generation (ETP) may be critically involved in obesity associated thromboembolism.Methods: Three hundred and one participants of the STyrian Juvenile OBesity (STYJOBS)/Early DEteCTion of Atherosclerosis (EDECTA) study cohort (age, 16–58years) were analysed. ETP was measured by the new CE-IVD marked Siemens-Innovance® ETP test on a BCS-XP analyser, and correlated to clinical findings and extended lipometry-based anthropometric data, biomarkers, and coagulation parameters.Results: In the overweight/obese study group, ETP and fibrinogen levels were significantly higher compared to controls (p (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537643 Mon, 31 Oct 2011 04:00:00 +0100 5537643 http://www.medworm.com/index.php?rid=5537638&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS002191501100997X%2Fabstract%3Frss%3Dyes Conclusion: Our results are in line with the new concept of a global cardiovascular disease combining atherosclerosis and VTE. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537638 Mon, 31 Oct 2011 04:00:00 +0100 5537638 http://www.medworm.com/index.php?rid=5537625&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011010021%2Fabstract%3Frss%3Dyes This study suggests that Psgl-1 deficiency leads to reduced atherosclerosis and adhesive interactions between endothelial cells and leukocytes by indirectly regulating endothelial responses to cytokine stimulation. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537625 Mon, 31 Oct 2011 04:00:00 +0100 5537625 http://www.medworm.com/index.php?rid=5537619&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009919%2Fabstract%3Frss%3Dyes Conclusions: We report for the first time that TSPs 1-4 are expressed in human aortic valves. CAVD is characterized by myofibroblastic proliferation and neovascularization associated upregulation of TSP-2 expression, as well as inactivation of Akt and NF-κB. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537619 Mon, 31 Oct 2011 04:00:00 +0100 5537619 http://www.medworm.com/index.php?rid=5537617&cid=s_34525_7_f&fid=34525&url=http%3A%2F%2Fwww.atherosclerosis-journal.com%2Farticle%2FPIIS0021915011009890%2Fabstract%3Frss%3Dyes Conclusion: An initial exposure to a n-6 PUFA rich diet compared to a MUFA rich diet reduces atherosclerotic lesions and this protection probably involves oxidative stress induced by PUFA. (Source: Atherosclerosis) Atherosclerosis journals http://www.medworm.com/rss/comments.php?id=5537617 Mon, 31 Oct 2011 04:00:00 +0100 5537617