MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'BMC Anesthesiology' source. Wed, 08 Feb 2012 07:39:17 +0100 http://www.medworm.com/index.php?rid=5646855&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F12%2F2 Conclusions: Clonidine appears promising more as an adjuvant in 0.2% ropivacaine and less than alone in the SLPB plus femoral block in children undergoing mild to moderate painful foot surgery, with no side effects.Trial registration: ClinicalTrials.gov, ISRCTN90832436, (ref: CCT-NAPN-20886). (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5646855 Wed, 01 Feb 2012 05:00:00 +0100 5646855 http://www.medworm.com/index.php?rid=5607850&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F12%2F1 Conclusions: Impaired preoperative handgrip strength may be associated with poorer postoperative outcomes, but further work exploring its predictive power is warranted using prospectively acquired, objectively defined measures of postoperative morbidity. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5607850 Tue, 17 Jan 2012 05:00:00 +0100 5607850 http://www.medworm.com/index.php?rid=5551861&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F26 Conclusions: During MV more severe lung injury develops after acid instillation as compared to sepsis. HVt causes VILI after acid instillation, but not during sepsis. However, this differential effect was not observed in the systemic release of mediators. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5551861 Wed, 28 Dec 2011 05:00:00 +0100 5551861 http://www.medworm.com/index.php?rid=5523864&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F25 Conclusion: NGX-4010 was well tolerated following pretreatment with lidocaine 2.5%/prilocaine 2.5% cream in patients with PHN. The tolerability of the patch application appeared comparable with that seen in other studies that used 4% lidocaine cream as the pretreatment anesthetic. This study is registered at www.clinicaltrials.gov as number NCT00916942. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5523864 Mon, 19 Dec 2011 05:00:00 +0100 5523864 http://www.medworm.com/index.php?rid=5494484&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F24 Conclusions: This citations classic allows for advances in anesthesiology and its subspecialties to be highlighted as well to provide useful manuscripts to guide patient care, direct future research, and serve as sources for future academic pursuit. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5494484 Mon, 12 Dec 2011 05:00:00 +0100 5494484 http://www.medworm.com/index.php?rid=5440225&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F23 Conclusion: Single shot infiltration with ropivacaine transiently improves postoperative pain control after breast cancer surgery.Trial registration number: NCT 01404377 (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5440225 Thu, 24 Nov 2011 05:00:00 +0100 5440225 http://www.medworm.com/index.php?rid=5431223&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F22 Conclusions: Ventilation with VT>10mL/kg PBW is still common, although poor correlation with PBW suggests it may be unintentional. BMI[greater than or equal to]30, female gender and height (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5431223 Mon, 21 Nov 2011 05:00:00 +0100 5431223 http://www.medworm.com/index.php?rid=5384187&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F21 Discussion The 'i-PERFORM Trial' will determine whether early rehabilitation for patients with sepsis is effective at improving patient outcomes with functional and physiological parameters reflecting long and short-term effects of early exercise and the safety in its application in critical illness.Trial Registration ACTRN12610000808044 (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5384187 Mon, 31 Oct 2011 04:00:00 +0100 5384187 http://www.medworm.com/index.php?rid=5358717&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F20 Conclusion: Insertion of DLTs with carinal hook is associated with technical problems and potentially life-threatening hazards have discouraged their use. Fiberoptic evaluation and repositioning solves most of the problems. Although amputation of the carinal hook has not been previously reported, clinicians should be alert. This case report emphasizes the utility of the fiberoptic bronchoscopy in the operating theatre for placement, positioning and inspection of the carinal hook DLT. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5358717 Fri, 28 Oct 2011 04:00:00 +0100 5358717 http://www.medworm.com/index.php?rid=5358718&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F19 Conclusions: Subcutaneous Dissociative Conscious Sedation (sDCS) as a new approach to airway is an acceptable and safe method for awake intubation and it can be suggested as a noninvasive substitute of low complication rate for regional airway blocks.Registration ID in IRCTIRCT201012075333N1 (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5358718 Wed, 26 Oct 2011 04:00:00 +0100 5358718 http://www.medworm.com/index.php?rid=5284896&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F18 Conclusion Levosimendan is widely used in our institution and many physicians believe that its use could decrease the need for mechanical support in children undergoing cardiac surgery or in children with decompensated heart failure. However, there is a lack of good empirical evidence in children to support this perception. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5284896 Wed, 05 Oct 2011 04:00:00 +0100 5284896 http://www.medworm.com/index.php?rid=5236605&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F17 Background: Our aim was to assess the efficacy of thoracic epidural anesthesia (EA) followed by postoperative epidural infusion (EI) and patient-controlled epidural analgesia (PCEA) with ropivacaine/fentanyl in off-pump coronary artery bypass grafting (OPCAB). Methods: In a prospective study, 93 patients were scheduled for OPCAB under propofol/fentanyl anesthesia and randomized to three postoperative analgesia regimens aiming at a visual analog scale (VAS) score (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5236605 Sun, 18 Sep 2011 04:00:00 +0100 5236605 http://www.medworm.com/index.php?rid=5195993&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F15 This study was designed to identify the central mechanism underlying the antinociceptive effect of esmolol. Methods: Wistar rats (7-21 d, 17-50 g) were anesthetized with ketamine (100-150 mg/kg) or isoflurane (5%) and decapitated. Horizontal slices (400-mum thick) of the lower brainstem containing the substantia gelatinosa (SG) of the caudal part of the spinal trigeminal nucleus (Sp5c), in which the nociceptive primary afferents form the first intracranial synapses, were made with a vibrating slicer. The miniature inhibitory and excitatory postsynaptic currents (mIPSCs and mEPSCs, respectively) were simultaneously recorded from visually identified SG neurons of the Sp5c in the presence of tetrodotoxin (1 muM). Additionally, mIPSCs were recorded during pharmacological isolation of GABA- and... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5195993 Sun, 04 Sep 2011 23:00:00 +0100 5195993 http://www.medworm.com/index.php?rid=5195992&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F16 Background: Children with viral respiratory infections who undergo general anesthesia are at increased risk of respiratory complications. We investigated the impact of RSV and influenza infection on perioperative outcomes in children undergoing general anesthesia. Methods: We performed a retrospective case-control study. All patients under the age of 18 years who underwent general anesthesia at our institution with confirmed RSV or influenza infection diagnosed within 24 hours following induction between October 2002 and September 2008 were identified. Controls were randomly selected and were matched by surgical procedure, age, and time of year in a ratio of three controls per case. The primary outcome was postoperative length of stay (LOS). Results: Twenty-four patients with laboratory-co... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=5195992 Sun, 04 Sep 2011 23:00:00 +0100 5195992 http://www.medworm.com/index.php?rid=4969690&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F14 Background: Physical examination has been advocated as a primary determinant of ICU-acquired weakness (ICU-AW). The purpose of the study is to investigate ICU-AW development by using Maximum Inspiratory Pressure (MIP) as a surrogate parameter of the standardized method to evaluate patients' peripheral muscle strength. Methods: Seventy-four patients were recruited in the study and prospectively evaluated in a multidisciplinary university ICU towards the appearance of ICU-AW. APACHE II admission score was 16+/-6 and ICU stay 26+/-18 days. ICU-AW was diagnosed with the Medical Research Council (MRC) scale for the clinical evaluation of muscle strength. MIP was measured using the unidirectional valve method, independently of the patients' ability to cooperate. Results: A significant correlatio... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4969690 Sat, 25 Jun 2011 23:00:00 +0100 4969690 http://www.medworm.com/index.php?rid=4936020&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F12 Conclusions: In the setting of severe sepsis and septic shock sublingual microcirculatory alterations were observed despite fulfillment of sepsis resuscitation guidelines. After infusion of a limited and fixed dose of MgS, microcirculatory perfusion did not improve over time.Trial registration: ClinicalTrials.gov NTC01332734. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4936020 Mon, 13 Jun 2011 23:00:00 +0100 4936020 http://www.medworm.com/index.php?rid=4853880&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F9 Background: Dexmedetomidine, an alpha2-adrenoceptor agonist, has been evaluated as an adjunct to anesthesia and for the delivery of sedation and perioperative hemodynamic stability. It provokes dose-dependent and centrally-mediated sympatholysis. Coronary artery bypass grafting (CABG) with extracorporeal circulation is a stressful procedure increasing sympathetic nervous system activity which could attenuate renal function due the interrelation of sympathetic nervous system, hemodynamics and renal function. We tested the hypothesis that dexmetomidine would improve kidney function in patients undergoing elective CABG during the first two postoperative days. Methods: This was a double-blind, randomized, parallel-group study. Patients with normal renal function and scheduled for elective CABG... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4853880 Sun, 22 May 2011 23:00:00 +0100 4853880 http://www.medworm.com/index.php?rid=4853879&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F10 Background: In the immediate postoperative period, obese patients are more likely to exhibit hypoxaemia due to atelectasis and impaired respiratory mechanics, changes which can be attenuated by non-invasive ventilation (NIV). The aim of the study was to evaluate the duration of any effects of early initiation of short term pressure support NIV vs. traditional oxygen delivery via venturi mask in obese patients during their stay in the PACU. Methods: After ethics committee approval and informed consent, we prospectively studied 60 obese patients (BMI 30-45) undergoing minor peripheral surgery. Half were randomly assigned to receive short term NIV during their PACU stay, while the others received routine treatment (supplemental oxygen via venturi mask). Premedication, general anaesthesia and ... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4853879 Sun, 22 May 2011 23:00:00 +0100 4853879 http://www.medworm.com/index.php?rid=4853878&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F11 This study is a randomized, controlled, patient and investigator blinded multicenter trial. Elective CABG patients are randomized to one of the following four groups: 1) control, 2) remote ischemic preconditioning, 3) remote ischemic postconditioning, or 4) remote ischemic pre- and postconditioning. Remote conditioning is applied at the arm by 3 cycles of 5 minutes of ischemia and reperfusion. Primary endpoint is the incidence AF in the first 72 hours after surgery, detected using a Holter-monitor. Secondary endpoints include length-of-stay on the intensive care unit and in-hospital, and the occurrence of major adverse cardiovascular events at 30 days, 3 months and 1 year.Based on an expected incidence in the control group of 27%, 195 patients per group are needed to detect with 80% power ... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4853878 Sun, 22 May 2011 23:00:00 +0100 4853878 http://www.medworm.com/index.php?rid=4705268&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F8 Background: : There is mounting experimental evidence that hypercapnic acidosis protects against lung injury. However, it is unclear if acidosis per se rather than hypercapnia is responsible for this beneficial effect. Therefore, we sought to evaluate the effects of hypercapnic (respiratory) versus normocapnic (metabolic) acidosis in an ex vivo model of ventilator-induced lung injury (VILI).MethodS: Sixty New Zealand white rabbit ventilated and perfused heart-lung preparations were used. Six study groups were evaluated. Respiratory acidosis (RA), metabolic acidosis (MA) and normocapnic-normoxic (Control - C) groups were randomized into high and low peak inspiratory pressures, respectively. Each preparation was ventilated for 1 hour according to a standardized ventilation protocol. Lung inj... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4705268 Tue, 12 Apr 2011 23:00:00 +0100 4705268 http://www.medworm.com/index.php?rid=4593551&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F7 Conclusions: Despite a relevant decrease of cerebral oxygen saturation was avoided in our study during cardiopulmonary bypass, incidence of POCD was comparable to that reported in patients without monitoring. A higher threshold for cSO2 may reduce the incidence of POCD. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4593551 Mon, 14 Mar 2011 00:00:00 +0100 4593551 http://www.medworm.com/index.php?rid=4532608&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F6 Conclusions: Combining the benefits of conventional direct laryngoscopy and videolaryngoscopy in one device, the C-MAC may serve as a standard intubation device for both routine airway management and educational purposes. However, in patients with suboptimal glottic view (C/L[greater than or equal to]2a), the C-MAC size 4 with straight blade technique may reduce the number of C/L 3 or C/L 4 views, and therefore facilitate intubation. Further studies on patients with difficult airway should be performed to confirm these findings. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4532608 Tue, 01 Mar 2011 00:00:00 +0100 4532608 http://www.medworm.com/index.php?rid=4507996&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F5 DiscussionThe study will describe cefazolin levels in plasma and the interstitial fluid of tissues during AAA open repair surgery. The effect of physiological changes to the patient mediated by surgery will also be determined. The results of this study will guide clinicians and pharmacists to effectively dose cefazolin in order to maximize the concentration of antibiotics in the tissues which are the most common site of surgical site infections. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4507996 Tue, 22 Feb 2011 00:00:00 +0100 4507996 http://www.medworm.com/index.php?rid=4502433&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F4 Conclusions: Pulsatile ventricular assist devices affect the coherence but not the gain or phase of the cerebral pressure-flow relationship in the low frequency range; thus whether there was any significant disruption of cerebral autoregulation mechanism was not exactly clear. The augmentation of input pressure fluctuations might contribute in part to the higher coherence observed. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4502433 Tue, 22 Feb 2011 00:00:00 +0100 4502433 http://www.medworm.com/index.php?rid=4502434&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F3 DiscussionThe study will describe cefazolin and piperacillin-tazobactam concentrations in plasma and the interstitial fluid of tissues in trauma and sepsis patients respectively. The results of this study will guide clinicians to effectively dose these antibiotics in order to maximize the concentration of antibiotics in the interstitial fluid of tissues. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4502434 Sun, 20 Feb 2011 00:00:00 +0100 4502434 http://www.medworm.com/index.php?rid=4483925&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F2 Conclusions: The BI analysis changed as a function of the changes of core temperature and independently of the shivering. In addition, our results support the beneficial use of active core rewarming to prevent accidental hypothermia. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4483925 Wed, 16 Feb 2011 00:00:00 +0100 4483925 http://www.medworm.com/index.php?rid=4331963&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F11%2F1 Conclusions: Continuous blood gas analysis with the CDITM 500 system was reliable and it might represent a new useful tool to accurately and timely monitor gas exchange in critically ill patients. Nonetheless, our findings need to be confirmed by larger studies to prove its reliability in the clinical setting. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4331963 Tue, 11 Jan 2011 00:00:00 +0100 4331963 http://www.medworm.com/index.php?rid=4300820&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F23 DISCUSSION The GRIP-COMPASS trial is the first controlled clinical trial to date that compares potassium targets. Other novel methodological elements of the study are that it is performed in ICU patients where both targets are within the normal range and that a computer-assisted potassium suppletion algorithm is used.Trial registrationNCT01085071 at ClinicalTrials.gov (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4300820 Fri, 31 Dec 2010 00:00:00 +0100 4300820 http://www.medworm.com/index.php?rid=4275559&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F22 Conclusions: Frequencies and mortality rates of diagnostic categories of sepsis differ depending on the cut-off for general and inflammatory variables. A cut-off of 3/8 variables is needed to identify almost all patients with septic shock who may benefit from optimal treatment. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4275559 Tue, 21 Dec 2010 00:00:00 +0100 4275559 http://www.medworm.com/index.php?rid=4242264&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F21 Conclusions: The bench-top and clinical studies both demonstrated that the LVLP cuff exerted approximately 30 cmH2O of pressure on the tracheal wall. These results are supported by our radiological study. We conclude that the LVLP cuff exerts an acceptable amount of pressure on the tracheal wall when it is operated at the recommended intracuff pressure. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4242264 Thu, 09 Dec 2010 00:00:00 +0100 4242264 http://www.medworm.com/index.php?rid=4225568&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F20 Conclusion: For maintenance of epithelia flow and nerve function and at the same time secure air sealing, this evaluation indicates that the cuff pressure needs to be checked as part of the procedures involved in induction of anaesthesia and eventually checked during surgery. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4225568 Fri, 03 Dec 2010 00:00:00 +0100 4225568 http://www.medworm.com/index.php?rid=4067902&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F19 Conclusions: The contents of a cylinder of a 50%/50% volume/volume (v/v) mixture of nitrous oxide and oxygen is in a homogenous single gas phase in a filled cylinder under normal conditions of handling and storage. The standard instructions given for handling before are justified based on previously conducted studies. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4067902 Thu, 14 Oct 2010 23:00:00 +0100 4067902 http://www.medworm.com/index.php?rid=4061977&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F18 Background: Early goal directed therapy improves survival in patients with septic shock. Central venous pressure (CVP) monitoring is essential to guide adequate resuscitation. Use of peripherally inserted central catheters (PICC) is increasing, but little data exists comparing a PICC to a conventional CVP catheter. We studied the accuracy of a novel PICC to transmit static and dynamic pressures in vitro. Methods: We designed a device to generate controlled pressures via a column of water allowing simultaneous measurements from a PICC and a standard triple lumen catheter. Digital transducers were used to obtain all pressure readings. Measurements of static pressures over a physiologic range were recorded using 5Fr and 6Fr dual lumen PICCs. Additionally, random repetitive pressure pulses we... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4061977 Mon, 11 Oct 2010 23:00:00 +0100 4061977 http://www.medworm.com/index.php?rid=4004435&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F17 Conclusions: At ICU discharge serum CRP concentration was a poor marker of post-ICU prognosis. Post-ICU death appears to be unrelated to the persistent inflammatory response. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=4004435 Sun, 26 Sep 2010 23:00:00 +0100 4004435 http://www.medworm.com/index.php?rid=3947603&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F16 Conclusion: BD can often mislead the clinician as to the actual Lac. Lac can now be measured in the OR in real time. Therefore, if clinicians in the operative setting want to know the Lac, it should be measured directly. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3947603 Wed, 08 Sep 2010 23:00:00 +0100 3947603 http://www.medworm.com/index.php?rid=3921761&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F15 Conclusions: Recovery from profound vecuronium-induced block is significantly faster with sugammadex, compared with neostigmine. Neostigmine did not rapidly reverse profound neuromuscular block (Trial registration number: NCT00473694). (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3921761 Tue, 31 Aug 2010 23:00:00 +0100 3921761 http://www.medworm.com/index.php?rid=3877900&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F14 Conclusions: Nitrous oxide does not affect the infusion requirements of cisatracurium.Trial registration: ClinicalTrials.gov NCT01152905; European Clinical Trials Database at http://eudract.emea.eu.int/ 2006-006037-41 (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3877900 Tue, 17 Aug 2010 23:00:00 +0100 3877900 http://www.medworm.com/index.php?rid=3859230&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F13 Conclusions: Temporal artery thermometry produces somewhat surprising disagreement with an established method of core temperature measurement and should not to be used in situations where body temperature needs to be measured with accuracy. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3859230 Wed, 11 Aug 2010 23:00:00 +0100 3859230 http://www.medworm.com/index.php?rid=3799830&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F12 Background: Desflurane during early reperfusion has been shown to postcondition human myocardium, in vitro. We investigated the role of adenosine and bradykinin receptors, and generation of radical oxygen species in desflurane-induced postconditioning in human myocardium. Methods: We recorded isometric contraction of human right atrial trabeculae hanged in an oxygenated Tyrode's solution (34 degrees Celsius, stimulation frequency 1Hz). After a 30-min hypoxic period, desflurane 6% was administered during the first 5 min of reoxygenation. Desflurane was administered alone or with pretreatment of N-mercaptopropionylglycine, a reactive oxygen species scavenger, 8-(p-Sulfophenyl)theophylline, an adenosine receptor antagonist, HOE140, a selective B2 bradykinin receptor antagonist. In separate gr... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3799830 Wed, 28 Jul 2010 23:00:00 +0100 3799830 http://www.medworm.com/index.php?rid=3711588&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F11 DiscussionThe DeLiT trial started in February 2007. We expect to reach our second interim analysis point in 2010. This large randomized controlled trial will provide a reliable assessment of the effects of corticosteroids, glucose control, and depth-of-anesthesia on perioperative inflammation and morbidity from major non-cardiac surgery. The factorial design will enable us to simultaneously study the effects of the three interventions in the same population, both individually and in different combinations. Such a design is an economically efficient way to study the three interventions in one clinical trial vs three.Trial registration: This trial is registered at Clinicaltrials.gov #: NTC00433251 (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3711588 Tue, 29 Jun 2010 23:00:00 +0100 3711588 http://www.medworm.com/index.php?rid=3707796&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F10 Conclusions: Org 25435 is an effective intravenous anaesthetic in man at doses of 3 and 4 mg/kg given over 1 minute. Longer infusions can maintain anaesthesia but recovery is slow. Hypotension and tachycardia during anaesthesia and slow recovery of consciousness after cessation of drug administration suggest this compound has no advantages over currently available intravenous anaesthetics. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3707796 Mon, 28 Jun 2010 23:00:00 +0100 3707796 http://www.medworm.com/index.php?rid=3692176&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F9 Conclusions: These findings suggest that renal function was preserved and that urine output improved without a decrease in systolic blood pressure, increase in vasoactive medication use, or an increase in resuscitation requirement in patients treated with low-dose fenoldopam. A randomized controlled trial is required to establish the efficacy of low-dose fenoldopam in critically ill burn patients with AKI. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3692176 Wed, 23 Jun 2010 23:00:00 +0100 3692176 http://www.medworm.com/index.php?rid=3684703&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F8 Conclusions: Washout time of 1MAC-h sevoflurane anesthesia is not appear to be effected by cigarette smoking in patients without significant pulmonary disease. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3684703 Mon, 21 Jun 2010 23:00:00 +0100 3684703 http://www.medworm.com/index.php?rid=3604771&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F7 Conclusion: Endoscopic TURP performed using either glucose 5% or saline 0.9% irrigating solution during and after surgery is associated with lower incidence of TUR syndrome, lower catheterization period, shorter hospital stay and no cardiac toxicity in comparison with glycine 1.5% solution.This clinical trail had been approved and registered in PACT Registry; with identification number for the registry is ATMR2010010001793131. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3604771 Thu, 27 May 2010 23:00:00 +0100 3604771 http://www.medworm.com/index.php?rid=3600586&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F6 Conclusions: In general, relatives to unconscious ICU patients expressed positive attitudes to drug trials in the ICU and the inclusion of their relative in drug trials. Consent by next-of-kin and deferred consent was acceptable to the majority of relatives. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3600586 Tue, 25 May 2010 23:00:00 +0100 3600586 http://www.medworm.com/index.php?rid=3539305&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F5 Background: Performance of patients immediately after anaesthesia is an area of special interest and so a clinical trial was conducted to compare Xenon with Isoflurane anaesthesia. In order to assess the early cognitive recovery the syndrome short test (SST) according to Erzigkeit (Geromed GmbH) was applied. Methods: ASA I and II patients undergoing long and short surgical interventions were randomised to receive either general anaesthesia with Xenon or Isoflurane. The primary end-point was the validated SST which covering memory disturbances and attentiveness. The test was used on the day prior to intervention, one and three hours post extubation. The secondary endpoint was the recovery index (RI) measured after the end of the inhalation of Xenon or Isoflurane. In addition the Aldrete sco... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3539305 Thu, 06 May 2010 23:00:00 +0100 3539305 http://www.medworm.com/index.php?rid=3476867&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F4 Conclusions: Our results indicate a certain agreement in short operations in spinal anaesthesia. By contrast, a large variety concerning the anaesthesiological approach in larger operations as well as in epidural analgesia in obstetrics could be revealed, the causes of which are assumed to be primarily rooted in particular departmental structures. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3476867 Fri, 16 Apr 2010 23:00:00 +0100 3476867 http://www.medworm.com/index.php?rid=3360260&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F3 This study aims to assess the effects on cerebral autoregulation and variability of cerebral blood flow due to intra-aortic balloon pump and inflation ratio weaning. Methods: Cerebral blood flow was measured using transcranial Doppler, in a convenience sample of twenty patients requiring balloon counterpulsation for refractory cardiogenic shock (N=7) or a single inotrope to maintain mean arterial pressure following an elective placement of an intra-aortic balloon pump for cardiac surgery (N=13). Simultaneous blood pressure at the aortic root was recorded via the intra-aortic balloon pump. Cerebral blood flow velocities were recorded for six minute intervals at a 1:1 balloon inflation-ratio (augmentation of all cardiac beats) and during progressive reductions of the inflation-ratio to 1:3 (... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3360260 Fri, 12 Mar 2010 00:00:00 +0100 3360260 http://www.medworm.com/index.php?rid=3308024&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F2 Conclusion: This report details an awake fiberoptic intubation in an adult with Morquio syndrome. We recommend that this approach be considered in patients with Morquio syndrome undergoing general anaesthesia. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3308024 Fri, 26 Feb 2010 00:00:00 +0100 3308024 http://www.medworm.com/index.php?rid=3284998&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F10%2F1 Background: Four nursing mothers consented to anaesthesia for urgent surgery only on condition that their ability to breast feed would not be impaired. Methods: Following induction of general anaesthesia with propofol and remifentanil, 65-69% xenon supplemented with remifentanil was used as an inhalational anaesthetic for maintenance. Results: After finishing surgery the women could be extubated between 2:52 and 7:22 minutes. The women were fully alert just minutes after extubation and spent about 45 minutes in the recovery room before discharge to a regular ward. They resumed regular breast feeding some time later. The propofol concentration in the blood was measured after 0, 30, 90, and 300 minutes and in the milk after 90 and 300 minutes. Just 90 minutes after extubation, the concentrat... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3284998 Fri, 19 Feb 2010 00:00:00 +0100 3284998 http://www.medworm.com/index.php?rid=3040559&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F9%2F8 DiscussionThis trial has been designed to complement two other clinical trials: B-Unaware and MACS (ClinicalTrials.gov numbers, NCT00281489 and NCT00689091). With the large patient numbers and complementary rigorous designs, it is envisaged that pre-specified meta-analyses will address some of the outstanding controversies and questions relating to processed electroencephalography monitoring.Trial registration: ClinicalTrials.gov Identifier: NCT00682825 (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=3040559 Mon, 30 Nov 2009 00:00:00 +0100 3040559 http://www.medworm.com/index.php?rid=2960260&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F9%2F7 Background: The incidence of intraoperative awareness with explicit recall is 1-2/1000 cases in the United States. The Bispectral Index monitor is an electroencephalographic method of assessing anesthetic depth that has been shown in one prospective study to reduce the incidence of awareness in the high-risk population. In the B-Aware trial, the number needed to treat in order to prevent one case of awareness in the high-risk population was 138. Since the number needed to treat and the associated cost of treatment would be much higher in the general population, the efficacy of the Bispectral Index monitor in preventing awareness in all anesthetized patients needs to be clearly established. This is especially true given the findings of the B-Unaware trial, which demonstrated no significant ... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=2960260 Thu, 05 Nov 2009 00:00:00 +0100 2960260 http://www.medworm.com/index.php?rid=2883733&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F9%2F6 Conclusion Although the noninvasive CO measurement appears promising, the noninvasive blood pressure assessment is clearly less reliable than the invasively measured blood pressure. Therefore, according to the present data application of the Nexfin HD monitoring system in the ICU cannot be recommended generally. Whether such a tool might be reliable in certain critically ill patients remains to be determined. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=2883733 Sun, 11 Oct 2009 23:00:00 +0100 2883733 http://www.medworm.com/index.php?rid=2642066&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F9%2F5 Conclusions: Remifentanil dosage adjustments are required during and after CPB due to marked changes in the V of the drug. Simulations indicate that a targeted blood concentration of 14 ng/mL is achieved and maintained in 50% of typical patients by administration of an initial dose of 18 ug remifentanil followed by an infusion of 3.7 ug/min before, during and post-CPB, supplemented with a bolus dose of 25 ug given at the start of CPB. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=2642066 Sun, 26 Jul 2009 23:00:00 +0100 2642066 http://www.medworm.com/index.php?rid=2470159&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F9%2F4 Conclusions: Sevoflurane appears to block chorionic arterial KCa++ and KATP channels. Sevoflurane also blocks voltage-operated calcium channels, and exerts a net vasodilatory effect in the in vitro foeto-placental circulation. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=2470159 Wed, 10 Jun 2009 04:00:00 +0100 2470159 http://www.medworm.com/index.php?rid=2331299&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F9%2F2 Conclusion: Single injection of local anaesthesia for sub-Tenon's block with mixture of lignocaine with adrenaline, bupivacaine and hyaluronidase was found to be superior to provide akinesia of ocular muscles compared to divided dose given by two injections. No difference in groups in terms of haemorrhage, chemosis, patient's satisfaction and intraocular pressure was found.Trial registrationTrial registration no-ISRCTN73431052 (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=2331299 Thu, 26 Mar 2009 04:00:00 +0100 2331299 http://www.medworm.com/index.php?rid=2303633&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F9%2F2 Conclusion: Single injection of local anaesthesia for sub-Tenon's block with mixture of lignocaine with adrenaline, bupivacaine and hyaluronidase was found to be superior to provide akinesia of ocular muscles compared to divided dose given by two injections. No difference in groups in terms of haemorrhage, chemosis, patient's satisfaction and intraocular pressure was found. Trial Registration:ISRCTN73431052 (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=2303633 Thu, 26 Mar 2009 04:00:00 +0100 2303633 http://www.medworm.com/index.php?rid=2303634&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F9%2F1 Conclusion: Colorectal-cancer recurrence risks were not greatly different in patients who were randomly assigned to 65% nitrous oxide or nitrogen during surgery. Our results may not support avoiding nitrous oxide use to prevent recurrence of colorectal cancer.Implications StatementThe risk of colorectal cancer recurrence was similar in patients who were randomly assigned to 65% nitrous oxide or nitrogen during colorectal surgery.Trial RegistrationCurrent Controlled Clinical Trials NCT00781352 http://www.clinicaltrials.gov (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=2303634 Tue, 03 Feb 2009 05:00:00 +0100 2303634 http://www.medworm.com/index.php?rid=2158717&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F9%2F1 Conclusion: Colorectal-cancer recurrence risks were not greatly different in patients who were randomly assigned to 65% nitrous oxide or nitrogen during surgery. Our results may not support avoiding nitrous oxide use to prevent recurrence of colorectal cancer. Implications Statement: The risk of colorectal cancer recurrence was similar in patients who were randomly assigned to 65% nitrous oxide or nitrogen during colorectal surgery. Trial Registration: Current Controlled Clinical Trials NCT00781352 (www.clinicaltrials.gov) Word Count: 262 (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=2158717 Tue, 03 Feb 2009 05:00:00 +0100 2158717 http://www.medworm.com/index.php?rid=2044177&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F8%2F8 Conclusions: The results of this study demonstrate the feasibility of recording contact heat evoked potentials with EEG during continuous and simultaneous fMRI. The combined use of the two methods can lead to identification of distinct patterns of brain activity indicative of pain and pro-nociceptive sensitisation in healthy subjects and chronic pain patients. Further studies are required for the technique to progress as a useful tool in clinical trials of novel analgesics. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=2044177 Wed, 17 Dec 2008 05:00:00 +0100 2044177 http://www.medworm.com/index.php?rid=1957641&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F8%2F7 Conclusions: In this animal model of ARDS, maximization of oscillatory frequencies with subsequent minimization of VT leads to hypercapnia that can only be reversed by adding av-ECLA. When combined with a recruitment strategy, these high frequencies do not impair oxygenation. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=1957641 Fri, 14 Nov 2008 05:00:00 +0100 1957641 http://www.medworm.com/index.php?rid=1854722&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F8%2F6 Conclusions: Fenoldopam is a rapid-acting, effective agent for intravenous control of blood pressure in children. The effective dose range is significantly higher in children undergoing anesthesia and surgery (0.8-1.2 mcg/kg/min) than as labeled for adults (0.05- 0.3 mcg/kg/min). The PK and side-effect profiles for children and adults are similar. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=1854722 Mon, 06 Oct 2008 04:00:00 +0100 1854722 http://www.medworm.com/index.php?rid=1846613&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F8%2F5 Conclusion: Both 200 μg and 300 μg provided comparable postoperative analgesia, which was superior to that provided by 100 μg IT morphine in patients undergoing total knee arthroplasty. Based on these findings, we recommend that 200 μg IT morphine be used in these patients.Trial registrationClinicalTrials.gov Identifier NCT00695045 (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=1846613 Wed, 24 Sep 2008 04:00:00 +0100 1846613 http://www.medworm.com/index.php?rid=1822023&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F8%2F5 Conclusions: Both 200mcg and 300mcg provided comparable postoperative analgesia, which was superior to that provided by 100mcg IT morphine in patients undergoing total knee arthroplasty. Based on these findings, we recommend that 200mcg IT morphine be used in these patients. Trial registration: ClinicalTrials.gov Identifier NCT00695045 (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=1822023 Wed, 24 Sep 2008 04:00:00 +0100 1822023 http://www.medworm.com/index.php?rid=1667053&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F8%2F4 Conclusion: Agent consumption with an automated closed-circuit anesthesia machine is higher than with a conventional anesthesia machine when the latter is used with a specific vaporizer-FGF sequence. Agent consumption during automated delivery might be further reduced by optimizing the algorithm(s) that manages the initial FGF or by tolerating some N2 in the circuit to minimize the need for intermittent flushing. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=1667053 Thu, 17 Jul 2008 04:00:00 +0100 1667053 http://www.medworm.com/index.php?rid=1633489&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F8%2F4 Conclusions: Agent consumption with an automated closed-circuit anesthesia machine is higher than with a conventional anesthesia machine when the latter is used with a specific vaporizer- FGF sequence. Agent consumption during automated delivery might be further reduced by optimizing the algorithm(s) that manages the initial FGF or by tolerating some N2 in the circuit to minimize the need for intermittent flushing. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=1633489 Thu, 17 Jul 2008 04:00:00 +0100 1633489 http://www.medworm.com/index.php?rid=1238518&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F8%2F3 Conclusion: The agreement between lithium dilution cardiac output and the pulse power algorithm in the PulseCO monitor remains acceptable for up to four hours in critically ill patients. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=1238518 Mon, 18 Feb 2008 05:00:00 +0100 1238518 http://www.medworm.com/index.php?rid=1216937&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F8%2F2 Conclusions: M-CAiOV compact gas IR analyzers are well compensated for carrier gas cross-sensitivity and are linear over the range of concentrations studied. IR and GC cannot be used interchangeably, because the deviations between GC and IR mount up to A+/- 20%, and because individual analyzers differ unpredictably in their performance. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=1216937 Fri, 08 Feb 2008 05:00:00 +0100 1216937 http://www.medworm.com/index.php?rid=1176558&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F8%2F1 Background Current analgesics have drawbacks such as delays in acquisition, lag-times for effect, and side effects. We recently presented a preliminary report of a new analgesic method involving a two-minute sciatic nerve press, which resulted in rapid and short-term relief of pain associated with dental and renal diseases. The present study investigated whether this technique was effective for pain associated with other disease types, and whether the relief was effective for up to one hour. Methods This randomized, placebo-controlled, parallel-group trial was conducted in four hospitals in Anhui Province, China. Patients with pain were sequentially recruited by participating physicians during clinic visits, and 135 patients aged 15 - 80 years were enrolled. Dental disease patients includ... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=1176558 Fri, 25 Jan 2008 05:00:00 +0100 1176558 http://www.medworm.com/index.php?rid=1016221&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F7%2F9 Background: Several techniques have been discussed as alternatives to the intermittent bolus thermodilution cardiac output (COPAC) measurement by the pulmonary artery catheter (PAC). However, these techniques usually require a central venous line, an additional catheter, or a special calibration procedure. A new arterial pressure-based cardiac output (COAP) device (FloTracTM, VigileoTM; Edwards Lifesciences, Irvine, CA, USA) only requires access to the radial or femoral artery using a standard arterial catheter and does not need an external calibration. We validated this technique in critically ill patients in the intensive care unit (ICU) using COPAC as the method of reference. Methods: We studied 20 critically ill patients, aged 16 to 74 years (mean, 55.5+/-18.8 years), who required bot... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=1016221 Fri, 09 Nov 2007 05:00:00 +0100 1016221 http://www.medworm.com/index.php?rid=754736&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F7%2F8 Conclusions: ASA-PS, age, type of surgery, ICU LOS and SAPS II could be seen as determinants of HRQOL. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=754736 Tue, 24 Jul 2007 04:00:00 +0100 754736 http://www.medworm.com/index.php?rid=720738&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F7%2F7 Background: Trauma and surgery may be complicated by pulmonary dysfunction, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), but the mechanisms are incompletely understood. Methods: We evaluated lung capillary protein permeability non-invasively with help of the 67Ga-transferrin pulmonary leak index (PLI) technique and extravascular lung water (EVLW) by the transpulmonary thermal-dye dilution technique in consecutive, mechanically ventilated patients in the intensive care unit within 24 h of direct, blunt thoracic trauma (n=5, 2 with ARDS), and within 12 h of indirect trauma by transhiatal oesophagectomy (n=8), abdominal surgery for cancer (n=6) and bone surgery (n=4). We als studied transfusion history, haemodynamics, oxygenation and mechanics of the lungs. The lun... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=720738 Mon, 09 Jul 2007 04:00:00 +0100 720738 http://www.medworm.com/index.php?rid=719070&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F7%2F6 Background: Gabapentin is an antiepileptic drug used in a variety of chronic pain conditions. Increasing numbers of randomized trials indicate that gabapentin is effective as a postoperative analgesic. This procedure-specific systematic review aims to analyse the 24-hour postoperative effect of gabapentin on acute pain in adults. Methods: Medline, The Cochrane Library and Google Scholar were searched for double-blind randomized placebo controlled trials of gabapentin for postoperative pain relief compared with placebo, in adults undergoing a surgical procedure. Qualitative analysis of postoperative effectiveness was evaluated by assessment of significant difference (P (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=719070 Sat, 07 Jul 2007 04:00:00 +0100 719070 http://www.medworm.com/index.php?rid=694509&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F7%2F5 Conclusions: The evidence supporting the clinical and economic attractiveness of drotrecogin alfa is not conclusive and further research appears to be indicated. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=694509 Mon, 25 Jun 2007 04:00:00 +0100 694509 http://www.medworm.com/index.php?rid=616437&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F7%2F4 This study describes a new manipulation: a 2-minute sciatic nerve press, for rapid short-term relief of pain brought on by various dental and renal diseases. Methods: this randomized, single-blind, placebo-controlled trial ran in three hospitals in Anhui Province, China, with an enrollment of 66 out of 111 solicited patients aged 16 to 74 years. Patients were recruited sequentially, by specific participating physicians at their clinic visits to three independent hospitals. The diseases in enrolled dental patients included dental caries, periodontal diseases and dental trauma. Renal diseases in recruits included kidney infections, stones and some other conditions. Patients were randomly assigned to receive the 2-minute sciatic nerve press or the placebo press. For the 2-minute sciatic nerve... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=616437 Wed, 16 May 2007 04:00:00 +0100 616437 http://www.medworm.com/index.php?rid=472777&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F7%2F3 Conclusions: The prevalence of AOD among medical ICU patients undergoing MV is high. Patients with AOD receive higher doses of sedation than their non-AOD counterparts to achieve similar RASS scores but do not undergo longer duration of MV. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=472777 Wed, 14 Mar 2007 04:00:00 +0100 472777 http://www.medworm.com/index.php?rid=472778&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F7%2F2 Conclusions: Retropharyngeal hematoma with life-threatening airway compromise can develop hours or days after a precipitating injury. Clinicians should be alert to the potential for this delayed airway collapse, and should also be prepared to rapidly secure the airway in this patient population likely to have concomitant cervical spinal or head injuries. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=472778 Mon, 12 Mar 2007 04:00:00 +0100 472778 http://www.medworm.com/index.php?rid=390337&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F7%2F1 We have developed a two-step procedure for preparing the skin before peripheral venous catheter (PVC) insertions. This procedure involves two successive swabbings with wipes soaked in alcoholic antiseptic. We investigated whether this two-step procedure was as effective and safe as the standard four-step procedure -- washing with detergent, rinsing, drying, applying antiseptic -- by carrying out a multicentre randomised equivalence study comparing the frequency of precursor signs of infection at the site of insertion for the two skin preparation procedures. The study was carried out over an eight-month period, and 248 PVC insertion sites were evaluated. The two-step procedure was used for 130 subjects and the standard procedure for 118. Taking into account all the confounding factors predi... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=390337 Wed, 31 Jan 2007 07:00:00 +0100 390337 http://www.medworm.com/index.php?rid=458329&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F7%2F1 We have developed a two-step procedure for preparing the skin before peripheral venous catheter (PVC) insertions. This procedure involves two successive swabbings with wipes soaked in alcoholic antiseptic. We investigated whether this two-step procedure was as effective and safe as the standard four-step procedure – washing with detergent, rinsing, drying, applying antiseptic – by carrying out a multicentre randomised equivalence study comparing the frequency of precursor signs of infection at the site of insertion for the two skin preparation procedures. The study was carried out over an eight-month period, and 248 PVC insertion sites were evaluated. The two-step procedure was used for 130 subjects and the standard procedure for 118. Taking into account all the confounding factors pre... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=458329 Wed, 31 Jan 2007 05:00:00 +0100 458329 http://www.medworm.com/index.php?rid=323818&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F15 Conclusion: Epidural analgesia with 1% lidocaine does not prolong the active-first and second stages of labor and does not increase vacuum-assisted or cesarean delivery rate. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=323818 Mon, 18 Dec 2006 07:00:00 +0100 323818 http://www.medworm.com/index.php?rid=458330&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F14 Conclusion: Almost all trials showed a considerable and consistently high rate of recurrence of emetic symptoms after placebo highlighting the need for a consequent antiemetic treatment. Future (placebo) controlled efficacy trials may use the presented empirical estimates for defining clinically relevant effects and for statistical power considerations. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=458330 Wed, 13 Dec 2006 05:00:00 +0100 458330 http://www.medworm.com/index.php?rid=270667&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F13 Conclusions: This system enabled assessment of inhaled anesthetic responsiveness with a higher precision than that previously reported. It is broadly adaptable for delivering an inhaled therapeutic (or toxin) to a population while monitoring its vital signs, motor reflexes, and providing precise control over environmental conditions. This system is also amenable to full automation. Data presented in this manuscript prove the utility of the controlled environment chambers and should allow for subsequent phenotyping of mice with targeted mutations that are expected to alter sensitivity to induction or emergence from anesthesia. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=270667 Fri, 10 Nov 2006 07:00:00 +0100 270667 http://www.medworm.com/index.php?rid=241264&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F11 Conclusion: Systemic sclerosis is a complex disease that involves multiple organ systems. Every aspects of anesthetic care may be altered or hindered by the pathogenesis of disease. Although the choice of regional or general anesthesia is unclear, to choose combined spinal epidural anesthesia may be useful. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=241264 Tue, 17 Oct 2006 06:00:00 +0100 241264 http://www.medworm.com/index.php?rid=166008&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F9 Conclusions: Based on the analysis of 4191 patients who underwent a primary cardiac operation, administration of tranexamic acid decreased the number of patients exposed to a transfusion or returned to theatre for bleeding in our institute. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=166008 Wed, 30 Aug 2006 06:00:00 +0100 166008 http://www.medworm.com/index.php?rid=458331&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F9 Conclusion: Based on the analysis of 4191 patients who underwent a primary cardiac operation, administration of tranexamic acid decreased the number of patients exposed to a transfusion or returned to theatre for bleeding in our institute. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=458331 Wed, 30 Aug 2006 04:00:00 +0100 458331 http://www.medworm.com/index.php?rid=78835&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F8 Background: To compare the effect of a sustained inflation followed by an incremental mean airway pressure trial during conventional and high-frequency oscillatory ventilation on oxygenation and hemodynamics in a large porcine model of early acute respiratory distress syndrome. Methods: Severe lung injury (Ali) was induced in 18 healthy pigs (55.3 +/- 3.9 kg, mean +/- SD) by repeated saline lung lavage until PaO2 decreased to less than 60 mmHg. After a stabilisation period of 60 minutes, the animals were randomly assigned to two groups: Group 1 (Pressure controlled ventilation; PCV): FIO2 = 1.0, PEEP = 5 cmH2O, VT = 6 ml/kg, respiratory rate = 30/min, I:E = 1:1; group 2 (High-frequency oscillatory ventilation; HFOV): FIO2 = 1.0, Bias flow = 30 l/min, Amplitude = 60 cmH2O, Frequency = 6 Hz... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=78835 Thu, 22 Jun 2006 06:00:00 +0100 78835 http://www.medworm.com/index.php?rid=63804&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F7 Conclusions: The kinetics of anesthetic gases can be adequately described by a mammilary compartmental model. Therefore, concepts that are traditionally thought of as being applicable to the kinetics of intravenous agents can be equally well applied to anesthetic gases. Distribution volumes and clearances cannot be equated to tissue volumes and blood flows respectively. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=63804 Tue, 13 Jun 2006 06:00:00 +0100 63804 http://www.medworm.com/index.php?rid=61520&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F7 Conclusions: The kinetics of anesthetic gases can be adequately described by a mammilary compartmental model. Therefore, concepts that are traditionally thought of as being applicable to the kinetics of intravenous agents can be equally well applied to anesthetic gases. Distribution volumes and clearances cannot be equated to tissue volumes and blood flows respectively. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=61520 Tue, 13 Jun 2006 06:00:00 +0100 61520 http://www.medworm.com/index.php?rid=726&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F5 Conclusions: The rate of data completion met our predefined criterion for determining a randomized trial to be feasible (at least 75% of patients tolerated the intervention and provided evaluable data). This novel intervention is acceptable to patients undergoing thoracotomy and does not interfere with standard preoperative care. There was no evidence of important adverse events. We are now testing the hypothesis that acupuncture significantly adds to standard perioperative pain management in a randomized trial. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=726 Wed, 03 May 2006 06:00:00 +0100 726 http://www.medworm.com/index.php?rid=727&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F4 Conclusion: If ventilator induced lung injury is ameliorated by a lower Pmean, a combined treatment approach using HFOV and prone positioning might result in further lung protection. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=727 Mon, 03 Apr 2006 06:00:00 +0100 727 http://www.medworm.com/index.php?rid=728&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F3 Conclusion: We demonstrated that a single, oral dose of valdecoxib when does not attenuate secondary hyperalgesia induced by heat/capsaicin in a cutaneous sensitization pain model in healthy volunteers. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=728 Fri, 10 Mar 2006 07:00:00 +0100 728 http://www.medworm.com/index.php?rid=729&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F2 Conclusion: Propofol and etomidate have relaxant properties in PA from human and normoxic rat. The relaxant effect is specifically accentuated in PA from CH rat, mainly via an effect on the pharmacomechanical coupling. Etomidate appears to be more efficient than propofol at identical concentration, but, taking into account clinical concentrations, etomidate is less potent than propofol, which effect was in the range of clinical doses. Although these findings provide experimental support for the preferential use of etomidate for haemodynamic stability in patients suffering from PAHT, the clinical relevance of the observations requires further investigation. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=729 Fri, 03 Mar 2006 07:00:00 +0100 729 http://www.medworm.com/index.php?rid=730&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F6%2F1 Conclusion: We did not find evidence that radiofrequency treatment of cervical facet joints and upper dorsal root ganglions is a better treatment than the infiltration of the greater occipital nerve, followed by TENS for patients fulfilling the clinical criteria of cervicogenic headache. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=730 Thu, 16 Feb 2006 07:00:00 +0100 730 http://www.medworm.com/index.php?rid=731&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F5%2F10 Conclusion: Spinal endoscopic adhesiolysis with targeted delivery of local anesthetic and steroid is an effective treatment in a significant number of patients with chronic low back and lower extremity pain without major adverse effects. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=731 Wed, 06 Jul 2005 06:00:00 +0100 731 http://www.medworm.com/index.php?rid=732&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F5%2F9 DiscussionPostoperative pain remains a significant clinical problem. Increased pain intensity with increased demand for opioid medication, and/or a relative unresponsiveness to pain treatment was reported both when the analgesia was administered by means of conventional nurse injection regimes and patient-controlled analgesia (PCA). Both the quality of the analgesia, and the sensitivity of postoperative models for assessing analgesic efficacy could be significantly influenced.The findings could be explained by increased penetration of an algesic anxiety-related nocebo influence (which we chose to call "anxiebo") relative to its analgesic placebo counterpart. To counteract this influence, the importance of psychological effects must be acknowledged, and doctors and attending nurses should f... BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=732 Mon, 27 Jun 2005 06:00:00 +0100 732 http://www.medworm.com/index.php?rid=733&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F5%2F8 Conclusion: Inhibition of the SERCA activity by CPA enhances halothane- and caffeine-induced contractures especially in MHS and MHE skeletal muscle and may help for the diagnostic assignment of MH susceptibility. The status of SERCA activity may play a significant but so far unknown role in the genesis of malignant hyperthermia. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=733 Thu, 09 Jun 2005 06:00:00 +0100 733 http://www.medworm.com/index.php?rid=734&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F5%2F7 Conclusion: The prevalence of patient hypothermia on ICU arrival was high. Hypothermia at time of admission to the ICU was not an independent factor for mortality or for staying longer in ICU. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=734 Mon, 06 Jun 2005 06:00:00 +0100 734 http://www.medworm.com/index.php?rid=735&cid=s_28807_5_f&fid=28807&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2253%2F5%2F6 Conclusion: All modern volatile anesthetics produce CO in desiccated sodalime. Sodalime temperature increase is a poor predictor of CO production. (Source: BMC Anesthesiology) BMC Anesthesiology journals http://www.medworm.com/rss/comments.php?id=735 Thu, 02 Jun 2005 06:00:00 +0100 735