BMC Cancer via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'BMC Cancer' source. Wed, 08 Feb 2012 08:41:15 +0100 Improving adherence to surveillance and screening recommendations for people with colorectal cancer and their first degree relatives: A randomized controlled trial http://www.medworm.com/index.php?rid=5666691&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F62 DiscussionResults of this study will contribute to the evidence base about effective strategies to a) improve adherence to surveillance recommendation for people with CRC; and b) improve adherence to screening recommendation for FDRs of people with CRC. The use of a population-based cancer registry to access the target population may have significant advantages in increasing the reach of the intervention. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5666691 Wed, 08 Feb 2012 05:00:00 +0100 5666691 The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility http://www.medworm.com/index.php?rid=5666696&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F57 Conclusions: These results suggested that TLR2 rs3804099 C/T and rs3804100 C/T polymorphisms were closely associated with HCC. In addition, the haplotypes composed of these two TLR2 synonymous SNPs have stronger effects on the susceptibility of HCC. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5666696 Tue, 07 Feb 2012 05:00:00 +0100 5666696 Increased serum sTRAIL levels were correlated with survival in bevacizumab-treated metastatic colon cancer http://www.medworm.com/index.php?rid=5666695&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F58 Conclusions: Serum sTRAIL levels might be a useful predictor of prognosis in metastatic colon cancer, in the early evaluation stages following bevacizumab treatment. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5666695 Tue, 07 Feb 2012 05:00:00 +0100 5666695 Neck control after definitive radiochemotherapy without planned neck dissection in node-positive head and neck cancers http://www.medworm.com/index.php?rid=5666694&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F59 Conclusions: The neck failure rate after definitive radiochemotherapy without planned neck dissection was 22%. Two-thirds of these were successfully salvaged with neck dissection and the ultimate neck control rate was 92%. Our results suggest that planned neck dissection might not be necessary in patients with complete response of primary site, no evidence of residual lesion >1.5 cm, or no necrotic lymph nodes at the 1-2 months follow-up evaluation after radiotherapy. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5666694 Tue, 07 Feb 2012 05:00:00 +0100 5666694 Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation http://www.medworm.com/index.php?rid=5666693&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F60 Conclusions: To our knowledge, this is the first report evidencing quantitatively decreased WNT7A levels in leukemia-derived cells and that WNT7A restoration in T-lymphocytes inhibits cell proliferation. In addition, our results also support the possible function of WNT7A as a tumor suppressor gene as well as a therapeutic tool. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5666693 Tue, 07 Feb 2012 05:00:00 +0100 5666693 Anti-apoptotic gene transcription signature of salivary gland neoplasms http://www.medworm.com/index.php?rid=5666692&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F61 Conclusion: In conclusion, we show an anti-apoptotic gene expression profile in salivary neoplasms in association with p53 staining, but independent of cell proliferation and tumour size. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5666692 Tue, 07 Feb 2012 05:00:00 +0100 5666692 Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma http://www.medworm.com/index.php?rid=5666697&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F56 Conclusions: FGF19 is critically involved in the development of HCCs. Targeting FGF19 inhibition is an attractive potential therapeutic strategy for HCC. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5666697 Mon, 06 Feb 2012 05:00:00 +0100 5666697 Axillary node metastasis from differentiated thyroid carcinoma with hurthle and signet ring cell differentiation. A case of disseminated thyroid cancer with peculiar histologic findings http://www.medworm.com/index.php?rid=5659363&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F55 ConclusionCurrently there are only few reported cases of axillary node metastases from thyroid cancer, and to our knowledge, this is the first report on axillary lymph node metastasis from follicular thyroid carcinoma. "Signet ring cell" is a morphologic feature shared by both benign and, more rarely, malignant follicular thyroid neoplasm, and it generally correlates with an arrest in folliculogenesis. Our case is one of the rare "signet ring cells" carcinomas so far described. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5659363 Fri, 03 Feb 2012 05:00:00 +0100 5659363 Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors. http://www.medworm.com/index.php?rid=5659365&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F53 Conclusions: Our results show that the somatic mtDNA mutations reported over all tumors are indistinguishable from a random selection from the set of all possible amino acid variations, and have therefore escaped the effects of purifying selection that act strongly at the population level. We show that the pathogenicity of somatic mtDNA mutations is a determining factor for the oncocytic phenotype. The opposite associations of the Complex I and Complex V variants with the oncocytic and non-oncocytic tumors implies that low mitochondrial membrane potential may play an important role in determining the oncocytic phenotype. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5659365 Thu, 02 Feb 2012 05:00:00 +0100 5659365 Androgenic suppression combined with radiotherapy for the treatment of prostate adenocarcinoma: a systematic review http://www.medworm.com/index.php?rid=5659364&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F54 Conclusions: Based on the findings of this systematic review, the evidence supports the use of androgen suppression with goserelin monotherapy as the standard treatment for patients with prostate cancer treated with radiotherapy, which are at high risk of recurrence or metastases. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5659364 Thu, 02 Feb 2012 05:00:00 +0100 5659364 Brain metastases from hepatocellular carcinoma: Clinical features and prognostic factors http://www.medworm.com/index.php?rid=5646944&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F49 Conclusions: BM from HCC is rare and associated with an extremely poor prognosis. However, patients with a low RPA class may benefit from aggressive treatment. The clinical implication of extracranial metastases in HCC patients with BM needs further assessment. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5646944 Wed, 01 Feb 2012 05:00:00 +0100 5646944 Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer http://www.medworm.com/index.php?rid=5646943&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F50 Conclusions: Our data showed that PIK3CA mutations were not common, but its amplification was very common in gastric cancer and may be a major mechanism in activating the PI3K/Akt pathway in gastric cancer. Importantly, Kaplan-Meier survival curves revealed that PIK3CA amplification was significantly positively associated with poor survival of gastric cancer patients. Collectively, the PI3K/Akt signaling pathway may be an effective therapeutic target in gastric cancer. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5646943 Wed, 01 Feb 2012 05:00:00 +0100 5646943 Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion http://www.medworm.com/index.php?rid=5646942&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F51 Conclusions: miR-133a expression was lost in breast cancer tissues, loss of which was associated with lymph nodes metastasis, high clinical stages and shorter relapse-free survivals of patients with breast cancer. Functionally, miR-133a can suppress tumor cell invasion and migration and targeted the expression of FSCN1. Future study will verify whether detection of miR-133a expression can served as a novel biomarker for breast cancer progression and patient prognosis. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5646942 Wed, 01 Feb 2012 05:00:00 +0100 5646942 Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy http://www.medworm.com/index.php?rid=5646941&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F52 Conclusions: uPA and PAI-1 concentrations in ND were higher in women with atypia and cancer compared to women with benign disease. Combining uPA, PAI-1 and TF in the assessment of women requiring diagnostic breast surgery maximized disease prediction. The assessment of these markers may prove useful in early breast cancer detection. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5646941 Wed, 01 Feb 2012 05:00:00 +0100 5646941 Cancer-initiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance http://www.medworm.com/index.php?rid=5637958&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F48 Conclusions: We characterized a self-renewing subpopulation of CICs found among four well known human cancer-derived cell lines (HeLa, SiHa, Ca Ski and C-4 I) and found that they express characteristic markers of stem cell, EMT and radioresistance. The fact that CICs demonstrated a higher degree of resistance to radiation than differentiated cells suggests that specific detection and targeting of CICs could be highly valuable for the therapy of tumors from the uterine cervix. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5637958 Sat, 28 Jan 2012 05:00:00 +0100 5637958 Expression and clinical significance of extracellular matrix protein 1 and vascular endothelial growth factor-C in lymphatic metastasis of human breast cancer http://www.medworm.com/index.php?rid=5637959&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F47 Conclusions: Both ECM1 and VEGF-C were overexpressed in breast cancer tissue samples. ECM1 expression was positively correlated with estrogen responsiveness and the metastatic properties of breast cancer. We conclude, therefore, that ECM1 and VEGF-C may have a synergistic effect on lymphangiogenesis to facilitate lymphatic metastasis of breast cancer. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5637959 Fri, 27 Jan 2012 05:00:00 +0100 5637959 Identification of a biomarker panel for colorectal cancer diagnosis http://www.medworm.com/index.php?rid=5637962&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F43 Conclusions: We have developed a tentative model for the diagnosis of colorectal cancer based on a biomarker panel. Our results indicate that the gene profile described herein can discriminate between non-cancerous and cancerous samples with 94.45% accuracy using different supervised classifiers (AUC values in the range of 0.997 and 0.955). (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5637962 Thu, 26 Jan 2012 05:00:00 +0100 5637962 Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis http://www.medworm.com/index.php?rid=5637961&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F44 Conclusions: We report that curcumin directly targets the SAC to induce apoptosis preferably in cells with high levels of phosphorylated Cdc27. Our studies provide a possible molecular mechanism why curcumin induces apoptosis preferentially in cancer cells and suggest that phosphorylation of Cdc27 could be used as a biomarker to predict the therapeutic response of cancer cells to curcumin. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5637961 Thu, 26 Jan 2012 05:00:00 +0100 5637961 The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer http://www.medworm.com/index.php?rid=5637960&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F45 Conclusions: Collectively, this work supports that Spy1 is a unique activator of Cdk1 in breast cancer cells and may represent a valuable drug target and/or a prognostic marker for subsets of breast cancers. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5637960 Thu, 26 Jan 2012 05:00:00 +0100 5637960 Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer http://www.medworm.com/index.php?rid=5628047&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F42 Conclusion: ALDH1 expression and its prognostic effect are age-dependent. Our results support the hypothesis that breast cancer biology is different in elderly patients compared to their younger counterparts and emphasizes the importance of taking into consideration age-specific interactions in breast cancer research. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5628047 Thu, 26 Jan 2012 05:00:00 +0100 5628047 Biomarkers for antitumor activity of bevacizumab in gastric cancer models http://www.medworm.com/index.php?rid=5628052&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F37 Conclusions: VEGF levels and VEGF/bFGF ratios in tumors were related to bevacizumab sensitivity of the xenografts tested. Further clinical investigation into useful predictive markers for bevacizumab sensitivity is warranted. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5628052 Wed, 25 Jan 2012 05:00:00 +0100 5628052 Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics http://www.medworm.com/index.php?rid=5628051&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F38 Conclusions: We propose a high confidence list of Hsp90 kinase clients, which provides new opportunities for targeted and combinatorial cancer treatment and diagnostic applications. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5628051 Wed, 25 Jan 2012 05:00:00 +0100 5628051 Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy http://www.medworm.com/index.php?rid=5628050&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F39 Background: Today's clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was to examine the tumor metabolic changes in patients with locally advanced breast cancer caused by neoadjuvant chemotherapy (NAC), relating these changes to clinical treatment response and long-term survival. Methods: Patients (n=89) participating in a randomized open-label multicenter study were allocated to receive either NAC as epirubicin or paclitaxel monotherapy. Biopsies were excised pre- and post-treatment, and analyzed by high resolution magic angle spinning magnetic resonance spectroscopy (HR MAS MRS). The metabolite profiles were examined by paired and unpaired multivariate methods and findings of important metabolites were confirmed by sp... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5628050 Wed, 25 Jan 2012 05:00:00 +0100 5628050 Disruption of CTCF at the miR-125b1 locus in gynecological cancers http://www.medworm.com/index.php?rid=5628049&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F40 Conclusions: A reduction of miR-125b1 expression in cancers, correlated with methylation, repressive histone marks and loss of CTCF binding at the promoter region. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5628049 Wed, 25 Jan 2012 05:00:00 +0100 5628049 Diagnostic value of fine-needle aspiration biopsy for breast mass: a systematic review and meta-analysis http://www.medworm.com/index.php?rid=5628048&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F41 Conclusions: FNAB is an accurate biopsy for evaluating breast malignancy if rigorous criteria are used. With regard to unsatisfactory samples, futher invasive procedures are required in order to minimize the chance of a missed diagnosis of breast cancer. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5628048 Wed, 25 Jan 2012 05:00:00 +0100 5628048 Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors http://www.medworm.com/index.php?rid=5628054&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F35 Conclusions: Data presented here identify a novel role for macrophages in EMT-promoted tumor progression. The observation that TAMs cluster with intra-epithelial fibroblastoid cells suggests that the role of macrophages in tumor-EMT extends beyond the invasive front. As macrophage infiltration and pronounced EMT tumor phenotype correlate with increased grade in NSCLC patients, we propose that TAMs also promote tumor progression by inducing EMT locally in tumors. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5628054 Tue, 24 Jan 2012 05:00:00 +0100 5628054 HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia http://www.medworm.com/index.php?rid=5628053&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F36 Background: The development of cervical cancer and its high-grade precursor lesions (Cervical Intraepithelial Neoplasia grade 2/3 [CIN2/3]) result from a persistent infection with high-risk human papillomavirus (hrHPV) types and the accumulation of (epi)genetic host cell aberrations. Epidemiological studies have demonstrated variable CIN2/3 and cancer risks between different hrHPV types. Recent genomic profiling studies revealed substantial heterogeneity in the chromosomal aberrations detected in morphologically indistinguishable CIN2/3 suggestive of varying cancer risk. The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected. Methods: Chromosom... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5628053 Tue, 24 Jan 2012 05:00:00 +0100 5628053 Cost-utility analysis of adjuvant goserelin (Zoladex) and adjuvant chemotherapy in premenopausal women with breast cancer http://www.medworm.com/index.php?rid=5619630&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F33 Conclusions: Goserelin therapy results in better survival and higher utility-weighted life-years, and is more cost-effective than TC or TEC chemotherapy. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5619630 Sat, 21 Jan 2012 05:00:00 +0100 5619630 Contribution of cell blocks obtained through endobronchial ultrasound-guided transbronchial needle aspiration to the diagnosis of lung cancer http://www.medworm.com/index.php?rid=5619629&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F34 Conclusions: Cell-block preparation from EBUS-TBNA samples is a simple way to provide additional information in lung cancer diagnosis. Analysis of cell blocks increases the diagnostic yield of the procedure by nearly seven per cent and allows for genetic analysis in a sixty per cent of the patients with metastatic adenocarcinoma. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5619629 Sat, 21 Jan 2012 05:00:00 +0100 5619629 Fascin overexpression promotes neoplastic progression in Oral Squamous Cell Carcinoma http://www.medworm.com/index.php?rid=5619631&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F32 Conclusions: In conclusion, our results indicate that fascin promotes tumor progression and activates AKT and MAPK pathways in OSCC-derived cells. Further, our correlative studies of fascin expression in OSCC with clinico-pathological parameters of the patients indicate that fascin may prove to be useful in prognostication and treatment of OSCC. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5619631 Fri, 20 Jan 2012 05:00:00 +0100 5619631 Risk factors associated with fatal pulmonary hemorrhage in locally advanced non-small cell lung cancer treated with chemoradiotherapy http://www.medworm.com/index.php?rid=5608001&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F27 Conclusions: Patients at high risk of fatal PH could be identified using a combination of independent risk factors. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5608001 Fri, 20 Jan 2012 05:00:00 +0100 5608001 Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells http://www.medworm.com/index.php?rid=5608000&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F28 CONCLUSION: These findings suggest that EP can exert antitumor activity in multiple myeloma U266 cells partly with antiangiogenic activity targeting JAK2/STAT3 signaling pathway as a potent cancer preventive agent for treatment of multiple myeloma cells. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5608000 Fri, 20 Jan 2012 05:00:00 +0100 5608000 Induction of cell proliferation and survival genes by estradiol-repressed microRNAs in breast cancer cells http://www.medworm.com/index.php?rid=5607999&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F29 Conclusions: These results demonstrate that E2 induces bcl-2, cyclin D1 and survivin by orchestrating the coordinate downregulation of a panel of miRNAs. In turn, the miRNAs manifest growth suppressive effects and control cell proliferation in response to E2. This sheds a new insight into the integral post-transcriptional regulation of cell proliferation and survival genes by miRNAs, a potential therapeutic option for breast cancer. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5607999 Fri, 20 Jan 2012 05:00:00 +0100 5607999 Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review http://www.medworm.com/index.php?rid=5607998&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F30 Conclusions: The overall estimated epidemiological burden of HPV-related cancers and non-malignant diseases is high in men in Europe. Approximately 30% of all new cancer cases attributable to HPV16/18 that occur yearly in Europe were estimated to occur in men. As in women, the vast majority of HPV-positive cancer in men is related to HPV16/18, while almost all HPV-related non-malignant diseases are due to HPV6/11. A substantial number of these malignant and non-malignant diseases may potentially be prevented by quadrivalent HPV vaccination. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5607998 Fri, 20 Jan 2012 05:00:00 +0100 5607998 Laparoscopy to predict the result of primary cytoreductive surgery in advanced ovarian cancer patients (LapOvCa-trial): a multicentre randomized controlled study http://www.medworm.com/index.php?rid=5607997&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F31 In this study we aim to assess whether adding laparoscopy to the diagnostic work-up of patients suspected of advanced ovarian carcinoma may prevent unsuccessful PDS for ovarian cancer. Methods: Multicentre randomized controlled trial, including all gynaecologic oncologic centres in the Netherlands and their affiliated hospitals. Patients are eligible when they are planned for PDS after conventional staging. Participants are randomized between direct PDS or additional diagnostic laparoscopy. Depending on the result of laparoscopy patients are treated by PDS within three weeks, followed by six courses of platinum based chemotherapy or with NACT and IDS 3-4 weeks after three courses of chemotherapy, followed by another three courses of chemotherapy. Primary outcome measure is the proportion o... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5607997 Fri, 20 Jan 2012 05:00:00 +0100 5607997 Cholesterol and the risk of grade-specific prostate cancer incidence: evidence from two large prospective cohort studies with up to 37 years' follow up. http://www.medworm.com/index.php?rid=5608003&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F25 Background: High cholesterol may be a modifiable risk factor for prostate cancer but results have been inconsistent and subject to potential "reverse causality" where undetected disease modifies cholesterol prior to diagnosis. Methods: We conducted a prospective cohort study of 12,926 men who were enrolled in the Midspan studies between 1970 and 1976 and followed up to 31st December 2007. We used Cox-Proportional Hazards Models to evaluate the association between baseline plasma cholesterol and Gleason grade-specific prostate cancer incidence. We excluded cancers detected within at least 5 years of cholesterol assay. Results: 650 men developed prostate cancer in up to 37 years' follow-up. Baseline plasma cholesterol was positively associated with hazard of high grade (Gleason score[greater... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5608003 Thu, 19 Jan 2012 05:00:00 +0100 5608003 TGF-beta1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells http://www.medworm.com/index.php?rid=5608002&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F26 Conclusion: Altogether, our results support that TGF-beta1 modulates the mRNA and protein levels of MMPs (MMP-2 and MMP-9) as much as their inhibitors (TIMP-2 and RECK). Therefore, this cytokine plays a crucial role in breast cancer progression by modulating key elements of ECM homeostasis control. Thus, although the complexity of this signaling network, TGF-beta1 still remains a promising target for breast cancer treatment. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5608002 Thu, 19 Jan 2012 05:00:00 +0100 5608002 Obesity, body composition, and prostate cancer http://www.medworm.com/index.php?rid=5608005&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F23 Conclusion: Our results suggest that associations between BMI and WC with high-grade prostate cancer are mediated through the measurement of total body FFM. It is unlikely that FFM causes prostate cancer, but instead provides a marker of testosterone and IGF1 activities involved with retaining lean mass as men age. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5608005 Wed, 18 Jan 2012 05:00:00 +0100 5608005 NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study http://www.medworm.com/index.php?rid=5608004&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F24 We examined tumor expression and prognostic effect of NKG2DL in breast cancer patients.Methods Our study population (n=677) consisted of all breast cancer patients primarily treated with surgery in our center between 1985 and 1994. Formalin-fixed paraffin-embedded tumor tissue was immunohistochemically stained with antibodies directed against MIC-A/MIC-B (MIC-AB), ULBP-1, ULBP-2, ULBP-3, ULBP-4, and ULBP-5.Results NKG2DL were frequently expressed by tumors (MIC-AB, 50% of the cases; ULBP-1, 90%; ULBP-2, 99%; ULBP-3, 100%; ULBP-4, 26%; ULBP-5, 90%) and often showed co-expression: MIC-AB and ULBP-4 (p=0.043), ULBP-1 and ULBP-5 (p=0.006), ULBP-4 and ULBP-5 (p (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5608004 Wed, 18 Jan 2012 05:00:00 +0100 5608004 A population-based cohort study of chest x-ray screening in smokers: lung cancer detection findings and follow-up http://www.medworm.com/index.php?rid=5596862&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F18 Conclusion: In the setting of CXR screening offered to a population-based cohort of smokers, screening participants who were diagnosed with LC had more frequently early-stage resectable disease and significantly enhanced long-term LC survival. These results translated into enhanced 10-year LC survival, independently related to CXR screening exposure, in the entire population-based cohort. Whether increased long-term LC-specific survival in the cohort corresponds to mortality reduction remains to be evaluated.Trial registration numberISRCTN90639073 (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5596862 Tue, 17 Jan 2012 05:00:00 +0100 5596862 DNA methylation regulates expression of Vascular Endothelial Growth Factor Receptor 2 (KDR) and Vascular Endothelial Growth Factor Receptor 3 (FLT4) http://www.medworm.com/index.php?rid=5596861&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F19 Conclusions: Our data show that VEGF-Rs KDR and FLT4 are silenced by DNA methylation. However, if the promoters are unmethylated, other factors (e.g. transactivation factors) determine the extent of KDR and FLT4 expression. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5596861 Tue, 17 Jan 2012 05:00:00 +0100 5596861 Golgi protein 73 versus alpha-fetoprotein as a biomarker for hepatocellular carcinoma: a diagnostic meta- analysis http://www.medworm.com/index.php?rid=5596863&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F17 Conclusions: The current evidence indicates that serum GP73 has a comparable accuracy to AFP for the diagnosis of HCC, while the value of serum GP73 in combination with AFP for HCC detection deserves further investigation. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5596863 Mon, 16 Jan 2012 05:00:00 +0100 5596863 Why do results conflict regarding the prognostic value of the methylation status in colon cancers? The role of the preservation method http://www.medworm.com/index.php?rid=5596867&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F12 Conclusions: Frozen samples gave reproducible results for bisulfite conversion and reliable methylation levels. FFPE samples gave unsatisfactory and non reproducible bisulfite conversions leading to random results for methylation levels. The use of FFPE collections to assess DNA methylation by bisulfite methods must not be recommended. This can partly explain the conflicting results on the prognosis of CIMP colon cancers. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5596867 Fri, 13 Jan 2012 05:00:00 +0100 5596867 Space-time clustering of childhood central nervous system tumours in Yorkshire, UK http://www.medworm.com/index.php?rid=5596866&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F13 Conclusions: There was some evidence for a transient environmental component to the aetiology of PNETs. However, a possible role for chance cannot be excluded. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5596866 Fri, 13 Jan 2012 05:00:00 +0100 5596866 Second-line Treatment of Stage III/IV Non-Small-Cell Lung Cancer (NSCLC) with pemetrexed in routine clinical practice: Evaluation of performance status and health-related quality of life http://www.medworm.com/index.php?rid=5596865&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F14 Conclusions: In this large prospective, non-interventional study of second-line pemetrexed treatment in patients with advanced NSCLC, including 36% elderly patients ([greater than or equal to]70 years), physician-rated PS and self-rated HR-QoL were maintained or improved in the majority of patients.Trial registrationRegistered on ClinicalTrials.gov (NCT00540241) on October 4, 2007 (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5596865 Fri, 13 Jan 2012 05:00:00 +0100 5596865 Multicellular Tumor Spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics. Application to the gemcitabine / CHK1 inhibitor combination in pancreatic cancer. http://www.medworm.com/index.php?rid=5596864&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F15 The multicellular tumor spheroid (MCTS) is an in vitro model associating malignant-cell microenvironment and 3D organization as currently observed in avascular tumors. In order to evaluate the relevance of this model for pre-clinical studies of drug combinations, we analyzed the effect of gemcitabine alone and in combination with the CHIR-124 CHK1 inhibitor in a Capan-2 pancreatic cell MCTS model. Compared to monolayer cultures, Capan-2 MCTS exhibited resistance to gemcitabine cytotoxic effect. This resistance was amplified in EGF-deprived quiescent spheroid suggesting that quiescent cells are playing a role in gemcitabine multicellular resistance. After a prolonged incubation with gemcitabine, DNA damages and massive apoptosis were observed throughout the spheroid while cell cycle arrest ... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5596864 Fri, 13 Jan 2012 05:00:00 +0100 5596864 Incidence and survival of oesophageal and gastric cancer in England between 1998 and 2007, a population-based study. http://www.medworm.com/index.php?rid=5580884&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F11 Conclusions: An increased focus on prevention and early diagnosis, especially in deprived areas and in males, is required to improve outcomes for these cancers. Improved recording of tumour site, stage and morphology and the evaluation of focused early diagnosis programmes are also needed. The poor long-term survival reinforces the need for early detection and multidisciplinary care. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5580884 Thu, 12 Jan 2012 05:00:00 +0100 5580884 "A novel in vivo model for the study of human breast cancer metastasis using primary breast tumor-initiating cells from patient biopsies" http://www.medworm.com/index.php?rid=5580885&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F10 Conclusions: Tumorspheres isolated under defined culture conditions from patient core biopsies were tumorigenic when transplanted into the mammary fat pad of NUDE mice, and metastasized to multiple mouse organs. Micrometastases in mouse organs demonstrated a dormancy period prior to outgrowth of macrometastases. The development of macrometastases with organ-specific phenotypic distinctions provides a superior model for the investigation of organ-specific effects on metastatic cancer cell survival and growth. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5580885 Tue, 10 Jan 2012 05:00:00 +0100 5580885 Frequency of CDH1 germline mutations in gastric carcinoma coming from high- and low-risk areas: metanalysis and systematic review of the literature http://www.medworm.com/index.php?rid=5571868&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F8 Conclusions: E-cadherin genetic screenings performed in low-risk areas for gastric cancer identified a higher frequency of CDH1 germline mutations. This data could open new approaches in the gastric cancer prevention test; before proposing a proband candidate for the CDH1 genetic screening, geographic variability, alongside the family history should be considered. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5571868 Fri, 06 Jan 2012 05:00:00 +0100 5571868 Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia http://www.medworm.com/index.php?rid=5571867&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F9 Conclusion: NOTCH1 mutations alone or in combination with FBXW7 did not impact T-ALL prognosis. Nevertheless, complex NOTCH1 mutations appear to have a positive impact on OS and the SIL-TAL1 fusion was validated as a negative prognostic marker in our series of T-ALL. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5571867 Fri, 06 Jan 2012 05:00:00 +0100 5571867 HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast http://www.medworm.com/index.php?rid=5559404&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F4 Conclusions: MCF7 breast cancer cells cultured as 3-D spheroids are resistant to doxorubicin and this resistance is associated with an increased Pgp expression in the plasma membrane via activation of HIF-1. The same mechanism may be suggested for IMPC drug resistance. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5559404 Wed, 04 Jan 2012 05:00:00 +0100 5559404 Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation Therapy http://www.medworm.com/index.php?rid=5559403&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F5 Conclusion: Panels of biochemical markers are helpful to stratify pretherapeutically colorectal cancer patients for SIR-therapy and to early estimate the response to SIR-therapy. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5559403 Wed, 04 Jan 2012 05:00:00 +0100 5559403 Systematic review: conservative treatments for secondary lymphedema http://www.medworm.com/index.php?rid=5559402&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F6 We examined the effectiveness of conservative treatments for secondary lymphedema, as well as harms related to these treatments. Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, AMED, and CINAHL from 1990 to January 19, 2010. We obtained English- and non-English-language randomized controlled trials or observational studies (with comparison groups) that reported primary effectiveness data on conservative treatments for secondary lymphedema. For English-language studies, we extracted data in tabular form and summarized the tables descriptively. For non-English-language studies, we summarized the results descriptively and discussed similarities with the English-language studies. Results: Thirty-six English-language and eight non-English-language studies w... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5559402 Wed, 04 Jan 2012 05:00:00 +0100 5559402 A randomised controlled trial of a theory-based intervention to improve sun protective behaviour in adolescents ('You can still be HOT in the shade'): study protocol. http://www.medworm.com/index.php?rid=5559407&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F1 DiscussionThe study will provide valuable information about the effectiveness of the intervention in improving the sun protective behaviour of adolescents. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5559407 Tue, 03 Jan 2012 05:00:00 +0100 5559407 Human chorionic gonadotropin and its relation to grade, stage and patient survival in ovarian cancer http://www.medworm.com/index.php?rid=5559406&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F2 Conclusions: Serum human gonadotropin levels differ in patients with benign and malignant ovarian tumors. HCG is often expressed in ovarian cancer tissue with a certain variable relation to grade and stage.HCG expression correlates with LH-R expression in ovarian cancer tissue, which has previously been shown to be of prognostic value. Both, the hormone and its receptor, may therefore serve as targets for new cancer therapies. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5559406 Tue, 03 Jan 2012 05:00:00 +0100 5559406 Volumetric and MGMT parameters in glioblastoma patients: Survival analysis http://www.medworm.com/index.php?rid=5559405&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F12%2F3 Conclusions: Our findings implicate that volumetric parameters may have a significant role in the prognosis of GBM patients. Furthermore, volumetry could help not only to improve the prediction of outcome but also the outcome itself by identifying patients at high risk of treatment failure and, thus, seek alternative treatment for these patients. In this small series, MGMT protein was associated with less aggressive tumor characteristics. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5559405 Tue, 03 Jan 2012 05:00:00 +0100 5559405 Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo http://www.medworm.com/index.php?rid=5551953&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F529 Conclusions: The known, precise and consistent gene composition of this cancer mesenchymal transition signature, particularly when combined with simultaneous analysis of the adjacent microenvironment, provides unique opportunities for shedding light on the underlying mechanisms of cancer invasiveness as well as identifying potential diagnostic markers and targets for metastasis-inhibiting therapeutics. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5551953 Fri, 30 Dec 2011 05:00:00 +0100 5551953 Determinants of patient satisfaction in ambulatory oncology : a cross sectional study based on the OUT-PATSAT35 questionnaire http://www.medworm.com/index.php?rid=5551956&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F526 Background: The aim of this study was to identify factors associated with satisfaction with care in cancer patients undergoing ambulatory treatment. We investigated associations between patients' baseline clinical and socio-demographic characteristics, as well as self-reported quality of life, and satisfaction with care. Methods: Patients undergoing ambulatory chemotherapy or radiotherapy in 2 centres in France were invited, at the beginning of their treatment, to complete the OUT-PATSAT35, a 35 item and 13 scale questionnaire evaluating perception of doctors, nurses and aspects of care organisation. Additionally, for each patient, socio-demographic variables, clinical characteristics and self-reported quality of life using the EORTC QLQ-C30 questionnaire were recorded. Results: Among 692 ... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5551956 Wed, 28 Dec 2011 05:00:00 +0100 5551956 Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells http://www.medworm.com/index.php?rid=5551955&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F527 Conclusions: Baicalein reduces the migration and invasiveness of A431 cells through the inhibition of Ezrin expression, which leads to the suppression of tumor metastasis. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5551955 Wed, 28 Dec 2011 05:00:00 +0100 5551955 Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events http://www.medworm.com/index.php?rid=5551954&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F528 Conclusions: Our results suggest that BCR-ABL, TEL-PDGFRB and TEL-JAK2 regulate distinct and overlapping gene transcription profiles. Many of the genes identified are known to be involved in processes associated with leukemogenesis, including cell migration, proliferation and differentiation. This study offers the basis for further work that could lead to an understanding of the specificity of diseases caused by these chromosomal translocations. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5551954 Wed, 28 Dec 2011 05:00:00 +0100 5551954 Inhibition of N-linked glycosylation impairs ALK phosphorylation and disrupts pro-survival signaling in neuroblastoma cell lines http://www.medworm.com/index.php?rid=5537404&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F525 Conclusions: In this study we showed that inhibition of N-linked glycosylation affects ALK phosphorylation and disrupts downstream pro-survival signaling, indicating that inhibition of this post-translational modification may be a promising therapeutic approach. However, as tunicamycin is not a likely candidate for clinical use other approaches to alter N-linked glycosylation need to be explored. Future studies will assess whether the efficacy in inhibiting ALK activity might be enhanced by the combination of ALK specific small molecule and N-linked glycosylation inhibitors. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5537404 Thu, 22 Dec 2011 05:00:00 +0100 5537404 Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma http://www.medworm.com/index.php?rid=5524023&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F523 Conclusions: Taken together, downregulation of SAV1 and the consequent YAP1 activation are involved in the pathogenesis of high-grade ccRCC. It is an attractive hypothesis that Hippo signaling could be candidates for new therapeutic target. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5524023 Tue, 20 Dec 2011 05:00:00 +0100 5524023 Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide http://www.medworm.com/index.php?rid=5524022&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F524 Conclusions: Neuronal markers are aberrantly expressed in human GBMs, and NSE is consistently upregulated in different cellular stress conditions. Knockdown of NSE reduces the migration of GBM cells and sensitizes them to hypoxia, radiotherapy and chemotherapy. In addition, GBM patients with high NSE expression had significantly shorter survival than patients with low NSE expression. Collectively, these data suggest a role for NSE in the adaption to cellular stress, such as during treatment. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5524022 Tue, 20 Dec 2011 05:00:00 +0100 5524022 The association of APE1 -656T>G and 1349T>G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies http://www.medworm.com/index.php?rid=5514989&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F521 Conclusions: Although some modest bias could not be eliminated, the meta-analysis suggests that APE1 -656T>G polymorphism has a possible protective effect on cancer risk particularly among Asian populations whereas 1349T>G polymorphism does not contribute to the development of cancer. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5514989 Sun, 18 Dec 2011 05:00:00 +0100 5514989 The influence of cardiovascular morbidity on the prognosis in prostate cancer. Experience from a 12-year nationwide Danish population-based cohort study. http://www.medworm.com/index.php?rid=5504259&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F519 Conclusions: Preexisting IHD had minimal impact on mortality in prostate cancer patients, whereas overall mortality was 20% higher in prostate cancer patients with preexisting stroke compared to those without IHD or stroke. These results highlight the importance of differentiating between various comorbidities. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5504259 Thu, 15 Dec 2011 05:00:00 +0100 5504259 Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation http://www.medworm.com/index.php?rid=5504258&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F520 Conclusions: We provide evidence for EC154 targeting of HIF in CCRCC and for LBH589 acting as a suppressor of both HIF-1 and HIF-2 activity. We also demonstrate that 17-AAG and EC154, but not LBH589, can restore endothelial barrier function, highlighting a potentially new clinical application for Hsp90 inhibitors. Finally, given the discordance between HIF activity and protein expression, we conclude that HIF expression is not a reliable surrogate for HIF activity. Taken together, our findings emphasize the need to incorporate an integrated approach in evaluating Hsp90 inhibitors within the context of HIF suppression. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5504258 Thu, 15 Dec 2011 05:00:00 +0100 5504258 SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer http://www.medworm.com/index.php?rid=5504260&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F518 Conclusion: We demonstrated that increased expression of either SOX2 or nuclear beta-catenin are associated with distant metastases in right-sided CC. Additionally, SOX2 is also associated with lymphnode metastases. These data underline the importance of stemness-associated markers for the identification of CC with high risk for distant spread. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5504260 Wed, 14 Dec 2011 05:00:00 +0100 5504260 Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma http://www.medworm.com/index.php?rid=5504263&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F515 Conclusions: These data support the development of multi-center, randomized trials of DAB/IL2 as a monotherapy and in combination with other immunotherapeutic agents for the treatment of stage IV melanoma.Trial registrationNCT00299689 (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5504263 Tue, 13 Dec 2011 05:00:00 +0100 5504263 Prospective study of physical activity and risk of squamous cell carcinoma of the skin http://www.medworm.com/index.php?rid=5504262&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F516 Conclusions: Despite some suggestion that recreational activity in men and occupational activity in women are related to occurrence of SCC, there is no firm support for a role of physical activity in the development of cutaneous SCC. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5504262 Tue, 13 Dec 2011 05:00:00 +0100 5504262 Efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: a randomized controlled trial http://www.medworm.com/index.php?rid=5504261&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F517 DiscussionDelaying or preventing skeletal complication and improving physical function for men with bone metastases would provide clinically meaningful benefits to patients. However, exercise programs must be designed and executed with careful consideration of the skeletal complications associated with bone metastatic disease and cumulative toxicities from androgen deprivation such as osteoporosis and increased risk of fractures. The results from this study will form the basis for the development of a specific exercise prescription in this patient group in order to alleviate disease burden, counteract the adverse treatment related side-effects and enhance quality of life.Trial RegistrationACTRN: ACTRN12611001158954 (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5504261 Tue, 13 Dec 2011 05:00:00 +0100 5504261 Expression of delta-catenin is associated with progression of human astrocytoma http://www.medworm.com/index.php?rid=5494546&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F514 Conclusion: The results suggest that delta-catenin expression is associated with the malignant progression of astrocytoma and promotes astrocytoma cell invasion through upregulation of Rac1 activity. delta-Catenin expression levels may serve as a useful marker of the biological behavior of astrocytoma cells. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5494546 Mon, 12 Dec 2011 05:00:00 +0100 5494546 Regulation of hTERT by BCR-ABL at multiple levels in K562 cells http://www.medworm.com/index.php?rid=5486301&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F512 Conclusions: Our data reveal that BCR-ABL can regulate TA at multiple levels, including transcription, post-translational level, and proper localization. Thus, suppression of cell growth and induction of apoptosis by Gleevec treatment may be partially due to TA inhibition. Additionally, we have identified STAT5a as critical mediator of the hTERT gene expression in BCR-ABL positive CML cells, suggesting that targeting STAT5a may be a promising therapeutic strategy for BCR-ABL positive CML patients. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5486301 Fri, 09 Dec 2011 05:00:00 +0100 5486301 Plasma Secretory Phospholipase A2-IIa as a Potential Biomarker for Lung Cancer in Patients with Solitary Pulmonary Nodules http://www.medworm.com/index.php?rid=5486300&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F513 Conclusion: Our finding strongly suggests that plasma sPLA2-IIa is a potential lung biomarker to distinguish benign nodules from lung cancer and to aid lung cancer diagnosis in patients with SPNs. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5486300 Fri, 09 Dec 2011 05:00:00 +0100 5486300 Identification of alpha(1,6)fucosylated Proteins Differentially Expressed in Human Colorectal Cancer http://www.medworm.com/index.php?rid=5486305&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F508 Conclusion: All these results validate the importance of core-fucosylated proteins profile analysis to understand the mechanisms which promote cancer onset and progression and to discover new tumour markers or therapeutic targets. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5486305 Wed, 07 Dec 2011 05:00:00 +0100 5486305 Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO) http://www.medworm.com/index.php?rid=5486304&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F509 Conclusions: Our finding that increased EGFR gene copy numbers, activated EGFR and the E-cadherin status are potentially interesting biomarkers needs to be confirmed in larger randomized clinical trials.Trial registration: Multicentre clinical study with the European Clinical Trials Database number 2004-004024-12. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5486304 Wed, 07 Dec 2011 05:00:00 +0100 5486304 A phase II study evaluating neo-/adjuvant EIA chemotherapy, surgical resection and radiotherapy in high-risk soft tissue sarcoma http://www.medworm.com/index.php?rid=5486303&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F510 Conclusion: The current protocol is feasible for achieving local control rates, as well as OS and DFS comparable to previously published data on neo-/adjuvant chemotherapy in this setting. However, the definitive role of chemotherapy remains unclear in the absence of large, randomized trials. Therefore, the current regimen can only be recommended within a clinical study, and a possibly increased risk of secondary leukemias has to be taken into account.Trial Registration: ClinicalTrials.gov NCT01382030, EudraCT 2004-002501-72 (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5486303 Wed, 07 Dec 2011 05:00:00 +0100 5486303 The HOPE fixation technique - a promising alternative to common prostate cancer biobanking approaches http://www.medworm.com/index.php?rid=5486302&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F511 Conclusions: This is the first study, comparatively assessing the suitability of these fixation methods for diagnostic and research utilization. Overall, HOPE-fixed bio-specimens combine the benefits of FFPE- and fresh-frozen samples. Results of this study have the potential to expand on contemporary prostate tissue biobanking approaches and can serve as a model for other organs and tumors. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5486302 Wed, 07 Dec 2011 05:00:00 +0100 5486302 STAT3 activation in monocytes accelerates liver cancer progression http://www.medworm.com/index.php?rid=5476098&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F506 Conclusion: Our data suggest constitutively activated STAT3 monocytes promote liver tumorigenesis in clinical patients and animal experiments. Thus, STAT3 in tumor infiltrating inflammatory cellsmay an attractive target for liver cancer therapy. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5476098 Mon, 05 Dec 2011 05:00:00 +0100 5476098 TMPRSS2-ERG-specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-beta signaling http://www.medworm.com/index.php?rid=5476097&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F507 Conclusions: The TMPRSS2-ERG gene fusion results in the modulation of transcriptional patterns and cellular pathways with potential consequences in prostate cancer. Well-known biomarkers for prostate cancer detection were found to be associated with the gene fusion. Our results suggest that the fusion status should be considered in retrospective and future studies to assess biomarkers for prostate cancer detection, progression and targeted therapy. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5476097 Mon, 05 Dec 2011 05:00:00 +0100 5476097 A decade of progress in cancer research http://www.medworm.com/index.php?rid=5456879&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F498 To celebrate BMC Cancer's 10th anniversary, we present a special collection of exciting reviews and commentaries that mark key developments in the cancer field over the last decade. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5456879 Wed, 30 Nov 2011 05:00:00 +0100 5456879 Improved blood tests for cancer screening: general or specific? http://www.medworm.com/index.php?rid=5456878&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F499 Diagnosis of cancer at an early stage leads to improved survival. However, most current blood tests detect single biomarkers that are of limited suitability for screening, and existing screening programmes only look for cancers of one particular type. A new approach is needed. Recent developments suggest the possibility of blood-based screening for multiple tumour types. It may be feasible to develop a high sensitivity general screen for cancer using multiple proteins and nucleic acids present in the blood of cancer patients, based on the biological characteristics of cancer. Positive samples in the general screen would be submitted automatically to secondary screening using tests to help define the likelihood of cancer and provide some indication of its type. Only those with at high risk ... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5456878 Wed, 30 Nov 2011 05:00:00 +0100 5456878 Micro-RNAs as diagnostic or prognostic markers in human epithelial malignancies http://www.medworm.com/index.php?rid=5456877&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F500 Micro-RNAs (miRs) are important regulators of mRNA and protein expression; the ability of miR expression profilings to distinguish different cancer types and classify their sub-types has been well-described. They also represent a novel biological entity with potential value as tumour biomarkers, which can improve diagnosis, prognosis, and monitoring of treatment response for human cancers. This endeavour has been greatly facilitated by the stability of miRs in formalin-fixed paraffin-embedded tissues, and their detection in circulation. This review will summarize some of the key dysregulated miRs described to date in human epithelial malignancies, and their potential value as molecular bio-markers in FFPE tissues and blood samples. There remain many challenges in this domain however, with ... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5456877 Wed, 30 Nov 2011 05:00:00 +0100 5456877 The breast cancer genome - a key for better oncology http://www.medworm.com/index.php?rid=5456876&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F501 Molecular classification has added important knowledge to breast cancer biology, but implementation in the clinic has been limited. Full sequencing of breast cancer genomes has the potential to refine classification and give a more complete picture of the mutational profile of cancer and thus aid therapy decisions. Future treatment guidelines must be based on the knowledge derived from histopathological sub-classification of tumors, but with added information from genomic signatures when properly clinical validated. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5456876 Wed, 30 Nov 2011 05:00:00 +0100 5456876 Current views on the role of Notch signaling and the pathogenesis of human leukemia http://www.medworm.com/index.php?rid=5456875&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F502 The Notch signaling pathway is highly conserved from Drosophila to humans and plays an important role in the regulation of cellular proliferation, differentiation, and apoptosis.Constitutive activation of Notch signaling has been shown to result in excessive cellular proliferation and a wide range of malignancies including leukemias, glioblastoma, lung and breast cancers. Notch can also act as a tumor suppressor and its inactivation has been associated with an increased risk of spontaneous squamous cell carcinoma. This mini-review focuses on recent advances related to the mechanisms and the roles of activated Notch1, 2, 3 and 4 signaling in human lymphocytic leukemia, myeloid leukemia and B cell lymphoma, their significance and recent advances in Notch targeted therapies. (Source: BMC Canc... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5456875 Wed, 30 Nov 2011 05:00:00 +0100 5456875 Ten years of progress in radiation oncology http://www.medworm.com/index.php?rid=5456874&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F503 Over the last decade, BMC CANCER has continuously published important research from the field of radiation oncology. Major developments in this field include the introduction of new imaging modalities into radiotherapy planning, the availability of hardware and software for more precise delivery of radiation dose, the individualiziation of radiotherapy concepts, e. g. based on microarray data, and the combination of radiotherapy with molecular targeting approaches to overcome the radioresistance of tumor cells. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5456874 Wed, 30 Nov 2011 05:00:00 +0100 5456874 Targeting hypoxic tumour cells to overcome metastasis http://www.medworm.com/index.php?rid=5456873&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F504 The microenvironment within solid tumours can influence the metastatic dissemination of tumour cells, and recent evidence suggests that poorly oxygenated (hypoxic) cells in primary tumours can also affect the survival and proliferation of metastatic tumour cells in distant organs. Hypoxic tumour cells have been historically targeted during radiation therapy in attempts to improve loco-regional control rates of primary tumours since hypoxic cells are known to be resistant to ionizing radiation-induced DNA damage. There are, therefore, a number of therapeutic strategies to directly target hypoxic cells in primary (and metastatic) tumours, and several compounds are becoming available to functionally inhibit hypoxia-induced proteins that are known to promote metastasis. This mini-review summar... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5456873 Wed, 30 Nov 2011 05:00:00 +0100 5456873 Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell cancer. http://www.medworm.com/index.php?rid=5456872&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F505 This study intends to investigate whether the antitumor efficacy of everolimus can be increased by preventing the detrimental everolimus induced expansion of Tregs using a metronomic schedule of cyclophosphamide.Methods/designThis phase I-II trial is a national multi-center study of different doses and schedules of low-dose oral cyclophosphamide in combination with a fixed dose of everolimus in patients with mRCC not amenable to or progressive after a VEGF-receptor tyrosine kinase inhibitor containing treatment regimen. In the phase I part of the study the optimal Treg-depleting dose and schedule of metronomic oral cyclophosphamide when given in combination with everolimus will be determined. In the phase II part of the study we will evaluate whether the percentage of patients progression ... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5456872 Wed, 30 Nov 2011 05:00:00 +0100 5456872 Breast cancer patients with lobular cancer more commonly have a father than a mother diagnosed with cancer http://www.medworm.com/index.php?rid=5456880&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F497 Patients with lobular breast cancer are more likely to have a father diagnosed with cancer and this association is independent of previous family history of cancer, suggesting that other mechanisms such as sex-specific imprinting might be involved. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5456880 Mon, 28 Nov 2011 05:00:00 +0100 5456880 Pharmacogenetic profiling and cetuximab outcome in patients with advanced colorectal cancer http://www.medworm.com/index.php?rid=5449498&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F496 Conclusions: Present original data obtained in wt KRas patients corresponding to the current cetuximab-treated population clearly suggest that CCND1 A870G polymorphism may be used as an additional marker for predicting cetuximab efficacy, TTP and overall survival. In addition, FCGR3A F158V polymorphism was a significant independent predictor of overall survival. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5449498 Fri, 25 Nov 2011 05:00:00 +0100 5449498 Fast Track Multi-Discipline Treatment (FTMDT trial) Versus Conventional Treatment In Colorectal Cancer - The Design of A Prospective Randomized Controlled Study http://www.medworm.com/index.php?rid=5440263&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F494 Conclusions: The study initiates a new treatment model "Fast Track Multi-Discipline Treatment" for colorectal cancer, and will provide feasibility evidence on the new model "Fast Track Multi-Discipline Treatment" for patients with colorectal cancer.Trial registrationClinicaltrial.gov, ID. NCT 01080547 (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5440263 Thu, 24 Nov 2011 05:00:00 +0100 5440263 Association between Chronic Viral Hepatitis Infection and Breast Cancer Risk: a Nationwide Population-based Case-control Study http://www.medworm.com/index.php?rid=5440262&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F495 IntroductionIn Taiwan, there is a high incidence of breast cancer and a high prevalence of viral hepatitis. In this case-control study, we used a population-based insurance dataset to evaluate whether breast cancer in women is associated with chronic viral hepatitis infection. Methods: From the claims data, we identified 1958 patients with newly diagnosed breast cancer during the period 2000-2008. A randomly selected, age-matched cohort of 7832 subjects without cancer was selected for comparison. Multivariable logistic regression models were constructed to calculate odds ratios of breast cancer associated with viral hepatitis after adjustment for age, residential area, occupation, urbanization, and income. The age-specific ( (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5440262 Thu, 24 Nov 2011 05:00:00 +0100 5440262 A randomised feasibility study of EPA and Cox-2 inhibitor (Celebrex) versus EPA, Cox-2 inhibitor (Celebrex), Resistance Training followed by ingestion of essential amino acids high in leucine in NSCLC cachectic patients-ACCeRT Study. http://www.medworm.com/index.php?rid=5440264&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F493 DiscussionTo our knowledge ACCeRT offers for the first time the opportunity to investigate the effect of stimulating the anabolic skeletal muscle pathway with the use of PRT along with EAA alongside the combination of EPA and celecoxib in this population.Trial registration: ACTRN12611000870954 (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5440264 Wed, 23 Nov 2011 05:00:00 +0100 5440264 Adaptation to statins restricts human tumour growth in Nude mice http://www.medworm.com/index.php?rid=5440266&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F491 Conclusions: Taken together, these results showed that statin-resistant cells developed into smaller tumours than statin-sensitive cells. This may be reflective of the cancer restricting activity of statins in humans, as suggested from several retrospective studies with subjects undergoing statin therapy for several years. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5440266 Tue, 22 Nov 2011 05:00:00 +0100 5440266 Clinical features and prognostic factors in patients with bone metastases from hepatocellular carcinoma after liver transplantation http://www.medworm.com/index.php?rid=5440265&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F492 Conclusion: The prognostic factors of bone metastases of HCC following LT are KPS and well-controlled intrahepatic. Even though survival is shorter for these patients, EBRT provides effective palliation of pain. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5440265 Tue, 22 Nov 2011 05:00:00 +0100 5440265 Correction: Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas http://www.medworm.com/index.php?rid=5431310&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F488 Correction: It was recently brought to our attention that, although the statistical analyses in Table 4 had passed the original peer-review of this paper, the risk ratio and value of the lower 95% confidence interval for some of the variables in Table 4 were not consistent with the p values. We have repeated the multi-variant statistical analysis of the original data with StatView software. This analysis produced different values for the risk ratios and 95% confidence intervals for variables other than age. The corrected Table 4 is presented below. The p values are unchanged, thus the original conclusions of the article are not altered. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5431310 Mon, 21 Nov 2011 05:00:00 +0100 5431310 Prognostic significance of a systemic inflammatory response in patients receiving first-line palliative chemotherapy for recurred or metastatic gastric cancer http://www.medworm.com/index.php?rid=5431309&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F489 Background: There is increasing evidence that the presence of an ongoing systemic inflammatory response is associated with poor prognosis in patients with advanced cancers. We evaluated the relationships between clinical status, laboratory factors and progression free survival (PFS), and overall survival (OS) in patients with recurrent or metastatic gastric cancer receiving first-line palliative chemotherapy. Methods: We reviewed 402 patients with advanced gastric adenocarcinoma who received first-line palliative chemotherapy from June 2004 and December 2009. Various chemotherapy regimens were used. Eastern Cooperative Oncology Group performance status (ECOG PS), C-reactive protein (CRP), albumin, Glasgow prognostic score (GPS), and clinical factors were recorded immediately prior to first... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5431309 Mon, 21 Nov 2011 05:00:00 +0100 5431309 Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line http://www.medworm.com/index.php?rid=5431308&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F490 Conclusions: Mutation at codon 307 in PTEN C2 loop alters its subcellular distribution with greater membrane localization while being excluded from the cell nucleus. This mutation may predispose breast epithelial cells to transformation events. Also, tumor cells harboring this mutation may be less susceptible to the cytotoxic effects of chemotherapeutics. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5431308 Mon, 21 Nov 2011 05:00:00 +0100 5431308 Paraneoplastic syndrome mimicking Adult-Onset Still's Disease caused by advanced lung cancer: a case report http://www.medworm.com/index.php?rid=5407019&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F487 Conclusions: Though rare, AOSD-like PNS can be one of the potential diagnoses in lung cancer patients with fever of undetermined origin, especially those having no response to antibiotic treatment. Management consists of control of the underlying malignancy and symptomatic treatment of the syndromes with non-steroidal anti-inflammatory drugs or corticosteroids. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5407019 Wed, 16 Nov 2011 05:00:00 +0100 5407019 Small Interfering RNA Targeting Mcl-1 Enhances Proteasome Inhibitor-Induced Apoptosis in Solid Malignant Tumors http://www.medworm.com/index.php?rid=5407021&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F485 Conclusions: Our results showed that it was not only Bik but also Mcl-1 accumulation during the treatment of proteasome inhibitors, and combining proteasome inhibitors with Mcl-1 siRNA would enhance the ultimate anticancer effect suggesting this combination might be a more effective strategy for cancer therapy. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5407021 Mon, 14 Nov 2011 05:00:00 +0100 5407021 Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment http://www.medworm.com/index.php?rid=5407020&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F486 Conclusions: Ki67 has predictive and prognostic value and is a feasible marker for clinical practice. It independently improved the prediction of treatment response and prognosis in a group of breast cancer patients receiving neoadjuvant treatment. As mean Ki67 values in patients with a pCR were very high, cut-off values in a high range above which the prognosis may be better than in patients with lower Ki67 values may be hypothesized. Larger studies will be needed in order to investigate these findings further. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5407020 Mon, 14 Nov 2011 05:00:00 +0100 5407020 Role and expression of FRS2 and FRS3 in prostate cancer. http://www.medworm.com/index.php?rid=5400010&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F484 Background: FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. Here we investigated FRS2 and FRS3 as a means of disrupting global FGF signalling in prostate cancer. Methods: FRS2 and FRS3 manipulation was investigated in vitro using over-expression, knockdown and functional assays. FRS2 and FRS3 expression was profiled in cell lines and clinical tumors of different grades. Results: In a panel of cell lines we observed ubiquitous FRS2 and FRS3 transcript and protein expression in both benign and malignant cells. We next tested functional redundancy of FRS2 and FRS3 in prostate cancer cells. In DU145 cells, specific FRS2 suppression inhibited FGF induced signalling. This effect was not apparent in cells sta... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5400010 Fri, 11 Nov 2011 05:00:00 +0100 5400010 Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence http://www.medworm.com/index.php?rid=5400011&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F483 Conclusion: PTX sensitizes cervical cancer cells to CIS-induced apoptosis and decreases the CIS-induced senescence in these cells via inhibition of NF-kappaB signaling pathway; diminishes expression of antiapoptotic proteins and the activation of caspases. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5400011 Thu, 10 Nov 2011 05:00:00 +0100 5400011 Mammary tumors that become independent of the type I insulin-like growth factor receptor express elevated levels of platelet-derived growth factor receptors http://www.medworm.com/index.php?rid=5400014&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F480 Conclusion: During IGF-IR independence, PDGFRs are upregulated and function to enhance tumor cell motility. These results demonstrate a novel interaction between the IGF-IR and PDGFRs and highlight an important, therapeutically relevant pathway, for tumor cell migration and invasion. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5400014 Wed, 09 Nov 2011 05:00:00 +0100 5400014 Clinicopathologic and gene expression parameters predicts liver cancer prognosis http://www.medworm.com/index.php?rid=5400013&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F481 Conclusion: When applied individually, clinicopathological parameters and gene expression offered similar predictive power for HCC prognosis. In contrast, a combination of the two types of data dramatically improved the power to predict HCC prognosis. Our results also provided a framework for understanding the impact of gene expression on the processes of tumorigenesis and clinical outcome. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5400013 Wed, 09 Nov 2011 05:00:00 +0100 5400013 Isometric Muscle Training of the Spine Musculature in Patients With Spinal Bony Metastases Under Radiation Therapy http://www.medworm.com/index.php?rid=5400012&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F482 This study is a prospective, randomized, monocentre, controlled explorative intervention study in the parallel-group design to determine the multidimensional effects of a course of exercises at first under physiotherapeutic instruction and subsequently performed by the patients independently for strengthening the paravertebral muscles of patients with metastases of the vertebral column parallel to their percutaneous radiotherapy. On the days of radiation treatment the patients in the control group shall be given physical treatment in the form of respiratory therapy and the so-called "hot roll". The patients will be randomized into one of the two groups: differentiated muscle training or physiotherapy with thirty patients in each group.DiscussionThe aim of the study is to evaluate the feasi... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5400012 Wed, 09 Nov 2011 05:00:00 +0100 5400012 Chemotherapeutic errors in hospitalised cancer patients: attributable damage and extra costs http://www.medworm.com/index.php?rid=5384355&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F478 Conclusion: Our findings point to the very small number of chemotherapy errors that actually reach patients, although problems in the chemotherapy ordering process are frequent, with the potential for being dangerous and costly. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5384355 Tue, 08 Nov 2011 05:00:00 +0100 5384355 The usefulness and feasibility of a screening instrument to identify psychosocial problems in patients receiving curative radiotherapy: a process evaluation http://www.medworm.com/index.php?rid=5384354&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F479 Conclusions: The screening procedure appeared to be feasible in a radiotherapy department. In general, patients' perspectives were at least moderate. Radiotherapists considered the usefulness and feasibility of the SIPP generally to be lower, but their evaluations were mixed. A positive attitude to using screening instruments like the SIPP needs to be encouraged among radiotherapists, as this may not only improve the usefulness of a screening instrument, but also patients' satisfaction with care.Trial Registration: NCT00859768 (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5384354 Tue, 08 Nov 2011 05:00:00 +0100 5384354 Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells http://www.medworm.com/index.php?rid=5384356&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F477 Conclusions: In the leukemia model, acquired resistance to 4-HPR is selective and persists in the absence of sphingolipid profile alteration. Therapeutically, the data demonstrate that alternative sphingolipid-modulating antitumoral strategies are suitable for both 4-HPR-resistant and sensitive leukemia cells. Thus, whereas sphingolipids may not be critical for maintaining resistance to 4-HPR, manipulation of cytotoxic sphingolipids should be considered a viable approach for overcoming resistance. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5384356 Mon, 07 Nov 2011 05:00:00 +0100 5384356 Hakai reduces cell-substratum adhesion and increases epithelial cell invasion http://www.medworm.com/index.php?rid=5384359&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F474 Conclusions Taken together, these results suggest that Hakai may be involved in two hallmark aspects of tumour progression, the lowering cell-substratum adhesion and the enhancement of cell invasion. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5384359 Thu, 03 Nov 2011 04:00:00 +0100 5384359 A cost-effectiveness analysis of a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy http://www.medworm.com/index.php?rid=5384358&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F475 Conclusions: Based on current evidence, PREP for CCRT in advanced head and neck cancer has the higher probability of being cost-effective when compared to UC. Moreover, the majority of sensitivity analyses produced ICERs that are well below the prevailing willingness to pay threshold for an additional QALY (range from dominance till E 45,906/QALY). (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5384358 Thu, 03 Nov 2011 04:00:00 +0100 5384358 GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines http://www.medworm.com/index.php?rid=5384357&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F476 Conclusions: Breast cancers exhibit a range of GnRH-R immunostaining, with higher levels of expression found in triple-negative and grade 3 cancers. However, functional cell surface receptors are rare in cultured cells. Intense GnRH-R signaling in transfected breast cancer cells did not markedly inhibit growth, in contrast to transfected HEK 293 cells indicating the importance of intracellular context. GnRH-R signaling could not counteract IGF-I receptor-tyrosine kinase addiction in MCF-7 cells. These results suggest that combinatorial strategies with growth factor inhibitors will be needed to enhance GnRH anti-proliferative effects in breast cancer (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5384357 Thu, 03 Nov 2011 04:00:00 +0100 5384357 YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma http://www.medworm.com/index.php?rid=5384361&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F472 Conclusion: Overexpression of YY1 in primary site of osteosarcoma is associated with the occurrence of metastasis and poor clinical outcome. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5384361 Wed, 02 Nov 2011 04:00:00 +0100 5384361 High prevalence of HPV in non-cervical sites of women with abnormal cervical cytology http://www.medworm.com/index.php?rid=5384360&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F473 Conclusions: Women with abnormal smears have widespread infection with high-risk HPV at the cervical, anal and oro-pharyngeal mucosal sites and may represent a higher risk population for HPV disease in the future. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5384360 Wed, 02 Nov 2011 04:00:00 +0100 5384360 Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells http://www.medworm.com/index.php?rid=5384362&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F470 Conclusions: The identification of a number of FDA-approved drugs as TRAIL sensitizers can expand chemotherapeutic options for combination treatments in prostate and pancreatic cancer diseases. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5384362 Tue, 01 Nov 2011 04:00:00 +0100 5384362 Protocol for the OUTREACH trial: a randomised trial comparing delivery of cancer systemic therapy in three different settings -patient's home, GP surgery and hospital day unit http://www.medworm.com/index.php?rid=5359812&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F467 DiscussionThe Outreach trial is the first randomised controlled trial conducted which compares delivery of out-patient based intravenous cancer treatment in two different community settings with standard hospital based treatment. Results of this study may better inform all key stakeholders regarding potential costs and benefits of transferring clinical services from hospital to the community.Clinical trial registration: ISRCTN66219681 (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5359812 Sat, 29 Oct 2011 04:00:00 +0100 5359812 SCOPE1: a randomised phase II/III multicentre clinical trial of definitive chemoradiation, with or without cetuximab, in carcinoma of the oesophagus http://www.medworm.com/index.php?rid=5359813&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F466 Background: Chemoradiotherapy is the standard of care for patients with oesophageal cancer unsuitable for surgery due to the presence of co-morbidity or extent of disease, and is a standard treatment option for patients with squamous cell carcinoma of the oesophagus. Modern regimens of chemoradiotherapy can lead to significant long-term survival. However the majority of patients will die of their disease, most commonly with local progression/recurrence of their tumours. Cetuximab may overcome one of the principal mechanisms of tumour radio-resistance, namely tumour repopulation, in patients treated with chemoradiotherapy.The purpose of this research is first to determine whether the addition of cetuximab to definitive chemoradiotherapy for treatment of patients with non-metastatic carcinom... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5359813 Fri, 28 Oct 2011 04:00:00 +0100 5359813 Protein and lipid MALDI profiles classify breast cancers according to the intrinsic subtype. http://www.medworm.com/index.php?rid=5359814&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F465 Conclusions: Protein and lipid profiles accurately distinguish tumor from adjacent normal tissue and classify breast cancers according to the intrinsic subtype. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5359814 Thu, 27 Oct 2011 04:00:00 +0100 5359814 Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: A tissue microarray study http://www.medworm.com/index.php?rid=5359816&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F463 Conclusions: These results suggest that epigenetic regulation plays a considerable role in the transformation of VIN to invasive vulvar neoplasia. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5359816 Wed, 26 Oct 2011 04:00:00 +0100 5359816 Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1 http://www.medworm.com/index.php?rid=5359815&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F464 Conclusions: In our human models, chemotherapeutic or targeted agents did not only interfere with the pronounced immunomodulatory properties of H-1PV, but also reinforced drug-induced tumor cell killing. H-1PV combined with cisplatin, vincristine or sunitinib induced effective immunostimulation via a pronounced DC maturation, better cytokine release and cytotoxic T-cell activation compared with agents alone. Thus, the clinical assessment of H-1PV oncolytic tumor therapy not only alone but also in combination strategies is warranted. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5359815 Wed, 26 Oct 2011 04:00:00 +0100 5359815 Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population http://www.medworm.com/index.php?rid=5346813&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F459 We examined if smoking or alcohol consumption modify associations between MTHFR polymorphisms and lung cancer risk. Methods: We evaluated the role of the MTHFR C677T (rs1801133) and A1298C (rs1801131) polymorphisms in a case-control study comprised of 462 lung cancer cases and 379 controls in a Japanese population. Logistic regression was used to assess the adjusted odds ratios (OR) and 95% confidence intervals (95% CI). Results: The TT genotype of the C677T polymorphism was significantly associated with an increased risk of lung cancer (OR = 2.27, 95% CI = 1.42 - 3.62, P (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5346813 Tue, 25 Oct 2011 04:00:00 +0100 5346813 A study of head and neck cancer treatment and survival among Indigenous and non-Indigenous people in Queensland, Australia, 1998 to 2004 http://www.medworm.com/index.php?rid=5346812&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F460 Conclusions: These findings show for the first time that Indigenous Australians with head and neck cancer receive less cancer treatment and suggest survival disparity could be reduced if treatment uptake was improved. There is a need for a greater understanding of the reasons for such treatment and survival disparities, including the impact of the poorer overall health on cancer outcomes for Indigenous Australians. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5346812 Tue, 25 Oct 2011 04:00:00 +0100 5346812 An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition http://www.medworm.com/index.php?rid=5346811&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F461 Conclusions: This model is able to integrate differential fitness effects on various cell types, allowing us to simultaneously capture effects on interacting cell types without having to perform separate experiments. This model system may be used to screen for new classes of cancer prevention agents designed to modulate the competition between normal and neoplastic cells. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5346811 Tue, 25 Oct 2011 04:00:00 +0100 5346811 Canadian Optically-guided approach for Oral Lesions Surgical (COOLS) trial: study protocol for a randomized controlled trial http://www.medworm.com/index.php?rid=5346810&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F462 DiscussionIn this paper we described the strategies, novelty, and challenges of this unique trial involving a surgical approach guided by the FV technology. The success of the trial requires training, coordination, and quality assurance across multiple sites within Canada. The COOLS trial, an example of translational research, may result in reduced recurrence rates following surgical treatment of early-stage oral cancer with significant impacts on survival, morbidity, patients' quality of life and the cost to the health care system.Trial Registration: Clinicaltrials.gov NCT01039298 (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5346810 Tue, 25 Oct 2011 04:00:00 +0100 5346810 Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients http://www.medworm.com/index.php?rid=5335007&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F458 Conclusions: G1613A and C1653T double mutations were frequently found in patients with HCC. A single G1613A mutation was associated with future emergence of HCC. These mutations may serve as useful markers in predicting HCC development. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5335007 Fri, 21 Oct 2011 04:00:00 +0100 5335007 Early metabolic response using FDG PET/CT and molecular phenotypes of breast cancer treated with neoadjuvant chemotherapy http://www.medworm.com/index.php?rid=5335013&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F452 Conclusions: The early metabolic response using FDG PET/CT could have a predictive value for the assessment of histopathologic non-response of stage II/III breast cancer treated with neoadjuvant chemotherapy. Our findings suggest that the initial SUV and the decline in SUV differed based on the molecular phenotype. (ClinicalTrials.gov number, NCT01396655) (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5335013 Thu, 20 Oct 2011 04:00:00 +0100 5335013 The PACOVAR-trial: A phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer http://www.medworm.com/index.php?rid=5335012&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F453 This study is designed as a multicenter phase I/II trial evaluating the optimal dose for pazopanib (phase I) as well as activity and tolerability of a combination regimen consisting of pazopanib and metronomic cyclophosphamide in the palliative treatment of patients with recurrent, platinum-resistant, pre-treated ovarian cancer (phase II). The patient population includes patients with histologically or cytologically confirmed diagnosis of EOC, cancer of the fallopian tube or peritoneal cancer which is platinumresistant or -refractory. Patients must have measurable disease according to RECIST criteria and must have failed available standard chemotherapy. Primary objectives are determination of the optimal doses for pazopanib (phase I) and the overall response rate according to RECIST criter... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5335012 Thu, 20 Oct 2011 04:00:00 +0100 5335012 Clinical implication of HLA class I expression in breast cancer http://www.medworm.com/index.php?rid=5335011&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F454 Background: Human leukocyte antigen (HLA)-class I molecules on tumor cells have been regarded as crucial sites where cytotoxic T lymphocytes (CTL) can recognize tumor-specific antigens and are strongly associated with anti-tumor activity. However, the clinical impact of HLA class I expression in breast cancer has not been clarified. Methods: A total of 212 breast cancer patients who received curative surgery from 1993 to 2003 were enrolled in the current study. HLA class I expression was examined immunohistochemically using an anti-HLA class I monoclonal antibody. The correlation between HLA class I positivity and clinical factors was analyzed. Results: The downregulation of HLA class I expression in breast cancer was observed in 69 patients (32.5%). HLA class I downregulation was signific... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5335011 Thu, 20 Oct 2011 04:00:00 +0100 5335011 Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma http://www.medworm.com/index.php?rid=5335010&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F455 Conclusion: Global analysis of genetic aberrations, as illustrated by performing array-CGH analysis on genomic DNA from only a few selected tumor cells of interest sampled from a progressing bone metastasis, can identify relevant therapeutic targets and genetic aberrations involved in malignant progression, thus emphasizing the importance and feasibility of this powerful tool on the road to more personalized cancer therapies in the future. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5335010 Thu, 20 Oct 2011 04:00:00 +0100 5335010 Effects of Magnolol on UVB-induced Skin Cancer Development in Mice and its Possible Mechanism of Action http://www.medworm.com/index.php?rid=5335009&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F456 Conclusions: Magnolol pretreatments prevent UVB- induced skin cancer development by enhancing apoptosis and causing cell cycle arrest at G2/M phase, and affecting various signaling pathways. Magnolol could be a potentially safe and potent anticarcinogenic agent for skin cancer. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5335009 Thu, 20 Oct 2011 04:00:00 +0100 5335009 Overexpression of Hepatoma-Derived Growth Factor in melanocytes does not lead to oncogenic transformation http://www.medworm.com/index.php?rid=5335008&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F457 Conclusions: The results therefore provide no evidence that HDGF has a transforming capacity in tumor development. Our results in combination with previous findings point to a possible role in cell differentiation and suggest that HDGF promotes tumor progression after secondary upregulation and may represent another protein fitting into the concept of non-oncogene addiction of tumor tissue. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5335008 Thu, 20 Oct 2011 04:00:00 +0100 5335008 Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa http://www.medworm.com/index.php?rid=5335015&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F450 Conclusions: Genome wide histone modification profiles can be used to find epigenetic aberrations in genes associated with cancer. This strategy gives further insights into the epigenetic contribution to the oncogenic process and may identify new biomarkers. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5335015 Wed, 19 Oct 2011 04:00:00 +0100 5335015 Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68 http://www.medworm.com/index.php?rid=5335014&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F451 Conclusions: Our findings have implications for the design of oncolytic therapies for cancer and offer insights into the nature of permissivity of tumor cells to viral infection. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5335014 Wed, 19 Oct 2011 04:00:00 +0100 5335014 TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child - evidence for chimerism involving a common mutant founder haplotype: case report. http://www.medworm.com/index.php?rid=5323601&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F449 Conclusion: This case represents one of the earliest ages at diagnosis of gastric cancer ever reported. It shows that cancer inheritance can occur in the absence of an obvious germline mutation, calling for caution in assessing early cancers in populations with common founder mutations such as p.R337H in Southern Brazil. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5323601 Mon, 17 Oct 2011 04:00:00 +0100 5323601 TNFRSF1B +676 T>G polymorphism predicts survival of non-Small cell lung cancer patients treated with chemoradiotherapy http://www.medworm.com/index.php?rid=5313807&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F447 Conclusions: Although the exact biological function for this SNP remains to be explored, our findings suggest a possible role of TNFRSF1B +676 T>G (rs1061622) in the prognosis of NSCLC. Further large and functional studies are needed to confirm our findings. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5313807 Fri, 14 Oct 2011 04:00:00 +0100 5313807 Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR) in pancreatic ductal adenocarcinoma identify a clinically high-risk group. http://www.medworm.com/index.php?rid=5313806&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F448 Conclusions: A high urinary suPAR/creatinine ratio represents a useful marker for the identification of a subset of patients with poorer outcome. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5313806 Fri, 14 Oct 2011 04:00:00 +0100 5313806 Chromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue http://www.medworm.com/index.php?rid=5313809&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F445 Conclusions: We suggest that the follow-up and the management of the patients with tongue OPMLs should receive a distinctive special attention. Clearly, this hypothesis should be validated in a prospective clinical study. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5313809 Thu, 13 Oct 2011 04:00:00 +0100 5313809 How the risk of liver cancer changes after alcohol cessation: A review and meta-analysis of the current literature http://www.medworm.com/index.php?rid=5313808&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F446 Conclusion: This is a relatively under researched area and this is reflected in the uncertainty of the findings. It is our view that it is not possible to extrapolate the results found here to the general population. Too few studies have addressed this question and of the studies that have, all have significant limitations. The key issue amongst the relevant studies is that it appears that current drinkers, abstainers and former drinkers are not composed of, or effectively adjusted to be, similar populations making inferences about risk changes impossible. This is a very difficult area to study effectively, but it is an important topic. More work is required to reduce both statistical uncertainty and tackle the various study limitations this paper highlights and until this is done, the cur... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5313808 Thu, 13 Oct 2011 04:00:00 +0100 5313808 Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines http://www.medworm.com/index.php?rid=5313813&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F441 Conclusions: We suggest that inclusion of the above drugs into PEL chemotherapy protocols may be justified. The heterogeneity in the drug response pattern however indicated that assay-guided individualized therapy might be required to optimize therapeutic response. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5313813 Wed, 12 Oct 2011 04:00:00 +0100 5313813 The effect of breast cancer awareness month on internet search activity - a comparison with awareness campaigns for lung and prostate cancer http://www.medworm.com/index.php?rid=5313812&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F442 Background: This work aimed to assess the effects of the annual breast cancer awareness campaign on internet search activity, and to compare these effects with those of similar campaigns in prostate and lung cancer. We further aimed to assess overall levels of online activity relating to all three neoplasms between 2004 and 2009. Methods: Google Insights for Search was employed to examine search trends for the term "breast cancer", across all Google domains between January 2004 and December 2009 (6 years). Search trends for both "prostate cancer" and "lung cancer" across all domains were also analysed for the same period, and these trends were compared with those for "breast cancer". Repeated measures ANOVA and Tukey post-hoc analyses were performed to assess for significant differences in... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5313812 Wed, 12 Oct 2011 04:00:00 +0100 5313812 Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo http://www.medworm.com/index.php?rid=5313811&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F443 Conclusions: Collectively, our data indicate that Nck2 effectively influences human melanoma phenotype progression. At the molecular level we propose that Nck2 in human primary melanoma promotes the formation of molecular complexes regulating proliferation and actin cytoskeleton dynamics by modulating kinases or phosphatases activities that results in increased levels of proteins phosphorylated on tyrosine residues. This study provides new insights regarding cancer progression that could impact on the therapeutic strategies targeting cancer. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5313811 Wed, 12 Oct 2011 04:00:00 +0100 5313811 High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: a feasibility study http://www.medworm.com/index.php?rid=5313810&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F444 Conclusions: Results from high-frequency ultrasonic measurements of human breast tissue specimens indicate that characteristics in the ultrasonic attenuation, spectra, and cepstra can be used to differentiate between normal, benign, and malignant breast pathologies. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5313810 Wed, 12 Oct 2011 04:00:00 +0100 5313810 A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence http://www.medworm.com/index.php?rid=5304015&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F437 Expression of a four-gene signature in histologically normal surgical margins is associated with oral squamous cell carcinoma recurrence, suggesting that a molecular test could potentially be developed to identify patients at a higher risk of local recurrence. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5304015 Tue, 11 Oct 2011 04:00:00 +0100 5304015 Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival. http://www.medworm.com/index.php?rid=5304014&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F438 Conclusions: The inclusion of second primary other cancer as an endpoint in DFS analyses significantly alters the DFS for patients with CRC. Researchers and journals must clearly define survival endpoints in all trial protocols and published manuscripts. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5304014 Tue, 11 Oct 2011 04:00:00 +0100 5304014 Intraoperative radiotherapy electron boost in advanced and recurrent epithelial ovarian carcinoma: a retrospective study http://www.medworm.com/index.php?rid=5304013&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F439 Background: Relapses of epithelial ovarian carcinoma (EOC) have a poor prognosis and are almost always fatal. The aim of this study was to evaluate the clinical outcome and toxicity of intraoperative electron beam radiation therapy (IOERT) in advanced and recurrent EOC. Methods: Forty-five women with EOC were treated with IOERT. Twenty-five patients had primary disease (PD) without distant metastasis at IOERT, and 20 patients had an isolated local recurrence (ILR) after surgery. All 45 patients in this series underwent optimal cytoreductive ([less than or equal to]1cm) surgery. The whole pelvic (WP) radiotherapy was intraoperatively delivered using 12 Mev electron beam; 43 patients received 18-20Gy and two patients received 10Gy. Thirty-three patients received postoperateive intraperitonea... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5304013 Tue, 11 Oct 2011 04:00:00 +0100 5304013 DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study http://www.medworm.com/index.php?rid=5304012&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F440 Conclusions: The results of this large German case-control study do not reveal associations of DNA repair pathway polymorphisms and risk of CAG. On the basis of a large number of CAG cases, they do not support associations of DNA repair pathway SNPs with CAG risk, but suggest the need of larger studies to disclose or exclude potential weak associations, or of studies with full coverage of candidate genes. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5304012 Tue, 11 Oct 2011 04:00:00 +0100 5304012 Double sampling of a faecal immunochemical test is not superior to single sampling for detection of colorectal neoplasia: a colonoscopy controlled prospective cohort study http://www.medworm.com/index.php?rid=5304018&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F434 Conclusion: At any cut off, "one of two FITs+" is the most sensitive double FIT sampling strategy. However, at a given specificity level, sensitivity of any double FIT sampling strategy for SRN is comparable to single FIT sampling at a different cut-off value. None of the double FIT strategies has a superior combination of sensitivity and specificity over single FIT. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5304018 Mon, 10 Oct 2011 04:00:00 +0100 5304018 Protein induced by vitamin K absence or antagonist-II production is a strong predictive marker for extrahepatic metastases in early hepatocellular carcinoma: a prospective evaluation http://www.medworm.com/index.php?rid=5304017&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F435 Conclusion: PIVKA-II production levels might be a good candidate predictive marker for extrahepatic HCC metastases, especially in patients with smaller and/or fewer tumors in the liver with in stages regardless of serum alpha-fetoprotein. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5304017 Mon, 10 Oct 2011 04:00:00 +0100 5304017 The time since last menstrual period is important as a clinical predictor for non-steroidal aromatase inhibitor-related arthralgia http://www.medworm.com/index.php?rid=5304016&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F436 Background: The clinical predictors of aromatase inhibitor-related arthralgia (AIA), a drug-related adverse reaction of aromatase inhibitors (AIs), remain unclear. Methods: AIA was prospectively surveyed every 4 months in 328 postmenopausal breast cancer patients administered a non-steroidal AI (anastrozole). Various clinicopathological parameters were recorded and analyzed (chi-square test, Fisher's exact test and logistic regression analysis). Results: The mean observation period was 39.9 months. AIA manifested in 114 patients (34.8%), with peaks of onset at 4 (33.7%) and 8 months (11.4%) after starting AI administration. Some cases manifested even after 13 months. AIA tended to occur in younger patients (incidences of 46.3%, 37.4% and 28.0% for ages of 65 years (p=0.063)) and decreased ... BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5304016 Mon, 10 Oct 2011 04:00:00 +0100 5304016 INSPIRE: A phase III study of the BLP25 liposome vaccine (L-BLP25) in Asian patients with unresectable stage III non-small cell lung cancer http://www.medworm.com/index.php?rid=5296517&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F430 DiscussionThe ongoing INSPIRE study is the first large study of a therapeutic cancer vaccine specifically in an East-Asian population. It evaluates the potential of maintenance therapy with L-BLP25 to prolong survival in East-Asian patients with stage III NSCLC where there are limited treatment options currently available.Study number: EMR 63325-012Clinicaltrials.gov reference: NCT01015443 (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5296517 Fri, 07 Oct 2011 04:00:00 +0100 5296517 Serum levels of selenium and smoking habits at age 50 influence long term prostate cancer risk; a 34 year ULSAM follow-up http://www.medworm.com/index.php?rid=5296516&cid=s_31104_6_f&fid=31104&url=http%3A%2F%2Fwww.biomedcentral.com%2F1471-2407%2F11%2F431 Conclusions: S-Se levels and smoking habits influence long-term risk of PrCa. Smoking as a risk factor for PrCa in men with low s-Se is relevant to explore further. Exploratory analyses of variations in OGG1 and MnSOD genes indicate that hypotheses about patterns of exposure to selenium and smoking combined with data on genetic variation in genes involved in DNA repair can be valuable to pursue. (Source: BMC Cancer) BMC Cancer journals http://www.medworm.com/rss/comments.php?id=5296516 Fri, 07 Oct 2011 04:00:00 +0100 5296516