MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'BMC Clinical Pharmacology' source. Wed, 08 Feb 2012 14:04:02 +0100 http://www.medworm.com/index.php?rid=5659905&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F12%2F4 Conclusion: Our study demonstrates that high blood levels of thiamine can be achieved rapidly with oral thiamine hydrochloride. Thiamine is absorbed by both an active and nonsaturable passive process. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5659905 Sat, 04 Feb 2012 05:00:00 +0100 5659905 http://www.medworm.com/index.php?rid=5659906&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F12%2F3 DiscussionContrast-induced nephropathy represents a significant source of hospital morbidity and mortality. Over the last ten years, acetylcysteine has been administered prior to contrast to reduce the risk of contrast-induced nephropathy. Randomized controlled trials, however, have not reliably demonstrated renoprotection; a recent large randomized controlled trial assessing a dose of oral acetylcysteine selected without mechanistic insight did not reduce the incidence of contrast-induced nephropathy. Our study should reveal the mechanism of effect of acetylcysteine on renal function and identify an appropriate route for future dose response studies and in time randomized controlled trials.Trial registration: Clinical Trials.gov: NCT00558142; EudraCT: 2006-003509-18. (Source: BMC Clinical... BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5659906 Fri, 03 Feb 2012 05:00:00 +0100 5659906 http://www.medworm.com/index.php?rid=5581975&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F12%2F2 Conclusions: The authors present a fast, economical and robust method for routine therapeutic drug monitoring comprising five immunosuppressants including mycophenolic acid. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5581975 Wed, 11 Jan 2012 05:00:00 +0100 5581975 http://www.medworm.com/index.php?rid=5572255&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F12%2F1 Conclusions: Although the short-term nature of this study may limit the potential for assessing improvements in function, it is noteworthy that in the present short-term study significant improvements in patient personal and social functioning with paliperidone ER treatment were observed, as assessed by PSP scale.Trial Registration: Clinical Trials. PAL-TWN-MA3 (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5572255 Fri, 06 Jan 2012 05:00:00 +0100 5572255 http://www.medworm.com/index.php?rid=5552422&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F22 Conclusions: In this group of septic cirrhotic patients with very high mortality, etomidate increased ICU mortality. Subsequent use of hydrocortisone appears to have no benefit beyond decreasing vasopressor requirements. The lowest mortality was observed in patients who did not receive etomidate but received hydrocortisone. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5552422 Fri, 30 Dec 2011 05:00:00 +0100 5552422 http://www.medworm.com/index.php?rid=5552421&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F23 Conclusions: A clinically significant signal for hyperkalemia with drospirenone was not demonstrated in the current study. Despite the bolded warning for hyperkalemia with joint drospirenone and spironolactone administration, physicians are actually using them together preferentially, and are not following the recommended potassium monitoring requirements in the package insert. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5552421 Fri, 30 Dec 2011 05:00:00 +0100 5552421 http://www.medworm.com/index.php?rid=5524917&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F21 Conclusions Patients treated with antipsychotics tend to use doses lower doses than DDDs . The opposite tendency was noted in patients treated with antidepressants. Only a small percentage of patients (14%) modified their neuroleptic therapy by increasing the dosage. On the contrary, patients treated with antidepressants mainly tended to reduce the doses of their drugs. This study highlights the tendency to follow combination therapies, prescribing SGAs together with anticholinergics in order to minimize extrapyramidal side effects or by combining two antidepressants. The study showed low adherence for both pharmaceutical therapies, which is typical in the setting of the analyzed diseases. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5524917 Tue, 20 Dec 2011 05:00:00 +0100 5524917 http://www.medworm.com/index.php?rid=5505011&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F20 Conclusions: The present study shows that price, familiarity, and availability were important factors in the choice of prescription medicines. The external characteristics of the medicines, for instance the color and shape of the tablet/capsule or the appearance of the package, were not significant characteristics for people. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5505011 Thu, 15 Dec 2011 05:00:00 +0100 5505011 http://www.medworm.com/index.php?rid=5408285&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F18 Conclusions: This survey revealed topics to address during future AM prescribing interventions such as dissemination of information about local AMR rates, promoting confidence in the quality of locally available AMs, redaction and dissemination of local AM guidelines and addressing the general public, and exploring the possibilities of internet-based training. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5408285 Tue, 15 Nov 2011 05:00:00 +0100 5408285 http://www.medworm.com/index.php?rid=5387077&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F17 Conclusions: The immunogenicity of panitumumab in the combination chemotherapy setting was infrequent and similar to the immunogenicity observed in the monotherapy setting. Panitumumab immunogenicity did not appear to alter pharmacokinetic or safety profiles. This low rate of immunogenicity may be attributed to the fully human nature of panitumumab.Trial registration: These trials were registered under ClinicalTrials.gov identifiers NCT00339183 (study 20050181), NCT00411450 (study 20060277), NCT00332163 (study 20050184), and NCT00364013 (study 20050203). (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5387077 Wed, 09 Nov 2011 05:00:00 +0100 5387077 http://www.medworm.com/index.php?rid=5347682&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F16 Conclusions: The present study indicates that consumer reports may contribute with important information regarding more serious psychiatric ADRs following antidepressant treatment. Consumer reporting may be considered a complement to traditional ADR reporting. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5347682 Tue, 25 Oct 2011 04:00:00 +0100 5347682 http://www.medworm.com/index.php?rid=5260898&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F15 Conclusions: Use of varenicline at maintenance dose of 1mg twice a day for longer than 6 weeks is associated with adverse gastrointestinal effects. In realistic terms, for every 5 treated subjects, there will be an event of nausea, and for every 24 and 35 treated subjects, we will expect an event of constipation and flatulence respectively. Family physicians should counsel patients of such risks accordingly during their maintenance therapy with varenicline. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5260898 Wed, 28 Sep 2011 04:00:00 +0100 5260898 http://www.medworm.com/index.php?rid=5161923&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F13 Conclusions: The results underline the differences between non-randomized and randomized studies comparing cognitive performance in opioid substitution treated patients (fewer deficits in buprenorphine patients vs. no difference between buprenorphine and methadone patients, respectively). Possible reasons for this are discussed. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5161923 Sat, 20 Aug 2011 23:00:00 +0100 5161923 http://www.medworm.com/index.php?rid=5097962&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F12 ${item.shortDescription} (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5097962 Fri, 05 Aug 2011 23:00:00 +0100 5097962 http://www.medworm.com/index.php?rid=5097963&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F11 ${item.shortDescription} (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5097963 Wed, 03 Aug 2011 23:00:00 +0100 5097963 http://www.medworm.com/index.php?rid=5070334&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F10 ${item.shortDescription} (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5070334 Mon, 25 Jul 2011 23:00:00 +0100 5070334 http://www.medworm.com/index.php?rid=5052870&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F9 ${item.shortDescription} (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=5052870 Wed, 20 Jul 2011 23:00:00 +0100 5052870 http://www.medworm.com/index.php?rid=4986292&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F8 Conclusion: Both drugs have a similar short-term effect on renal function. Indomethacin had a more prominent initial effect, while ibuprofen decreased renal function during the second and third courses similarly to indomethacin. The changes in renal function seen with ibuprofen treatment should be considered in fluid and electrolyte management, especially if treatment beyond one course is required. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4986292 Wed, 29 Jun 2011 23:00:00 +0100 4986292 http://www.medworm.com/index.php?rid=4885864&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F7 Conclusions: No clinically relevant pharmacokinetic or pharmacodynamic interactions were found when oral roflumilast was administered concomitantly with inhaled formoterol, including no effect on cardiac repolarisation. Roflumilast was well tolerated.Trial Registration: Clinicaltrials.gov NCT00940329 (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4885864 Tue, 31 May 2011 23:00:00 +0100 4885864 http://www.medworm.com/index.php?rid=4864378&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F6 Conclusions: Despite remaining barriers to cross, this study showed that future French pharmacists were keen to develop their role in patient care, beyond the traditional role of dispensing. However, the willingness of doctors and patients to consent should be investigated and also rigorous studies to support or refute the positive impact of pharmaceutical care on the quality of care should be carried out. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4864378 Tue, 24 May 2011 23:00:00 +0100 4864378 http://www.medworm.com/index.php?rid=4854469&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F5 Background: Thiazolidinediones (TZDs), rosiglitazone (RGZ) and pioglitazone (PGZ) are widely used as hypoglycemic drugs in patients with type 2 diabetes mellitus. The aim of our study was to investigate the profile of adverse drug reactions (ADRs) related to TZDs and to investigate potential risk factors of these ADRs. Methods: Type 2 diabetic patients were identified from the French Database of PharmacoVigilance (FPVD) between 2002 and 2006. We investigated ADR related to TZD, focusing on 4 ADR: edema, heart failure, myocardial infarction and hepatitis corresponding to specific WHO-ART terms. Results: Among a total of 99,284 adult patients in the FPVD, 2295 reports concerned type 2 diabetic patients (2.3% of the whole database), with 161 (7%) exposed to TZDs. The frequency of edema and ca... BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4854469 Mon, 23 May 2011 23:00:00 +0100 4854469 http://www.medworm.com/index.php?rid=4842942&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F4 Conclusion: Use of spironolactone is associated with an incidence of adverse events, which may have an impact on treatment compliance. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4842942 Thu, 19 May 2011 23:00:00 +0100 4842942 http://www.medworm.com/index.php?rid=4601585&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F3 Conclusions: Zibotentan absorption was unchanged, however, exposure was higher in subjects with hepatic or renal impairment due to slower clearance. This increased exposure did not result in differences in the range or severity of AEs observed.Trial registrationClinicaltrials.gov NCT00672581 (hepatic trial) and AstraZeneca study number D4320C00016 (renal trial; conducted in Germany). (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4601585 Thu, 17 Mar 2011 00:00:00 +0100 4601585 http://www.medworm.com/index.php?rid=4490804&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F2 Conclusions: Use of drugs was associated with constipation and diarrhoea in the general population. The associations are most likely adverse drug reactions and show that drug-induced symptoms need to be considered in subjects with these complaints. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4490804 Fri, 18 Feb 2011 00:00:00 +0100 4490804 http://www.medworm.com/index.php?rid=4433602&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F11%2F1 Conclusions: Phenoxodiol has a short plasma half-life, particularly in the free form, leading to a rapid attainment of steady state levels during continuous intravenous infusion.Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12610000334000 (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4433602 Thu, 03 Feb 2011 00:00:00 +0100 4433602 http://www.medworm.com/index.php?rid=4220929&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F16 Conclusions: The prevalence of polypharmacy and excessive polypharmacy, as well as the mean number of dispensed drugs per individual, increased year-by-year in Sweden 2005-2008. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4220929 Thu, 02 Dec 2010 00:00:00 +0100 4220929 http://www.medworm.com/index.php?rid=4089799&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F15 Conclusions: The study suggests that GS has had impacts on the activities of pharmaceutical companies in Finland. There were also some differences, although not statistically significant, between the surveyed original and generic product companies regarding the self-reported impacts of GS. More investigations are needed in this field. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4089799 Thu, 21 Oct 2010 23:00:00 +0100 4089799 http://www.medworm.com/index.php?rid=4083003&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F14 Conclusion: Both concentrations of a new liquid multi-dose formulation are bioequivalent to the FD reference formulation and all are well tolerated.Trial registration number: NCT01034735 (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4083003 Tue, 19 Oct 2010 23:00:00 +0100 4083003 http://www.medworm.com/index.php?rid=4005348&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F12 Background: Two randomised 12-week, double-blind, parallel-group, multicenter studies comparing oxycodone PR/naloxone PR and oxycodone PR alone on symptoms of opioid-induced bowel dysfunction in patients with moderate/severe non-malignant pain have been conducted. Methods: These studies were prospectively designed to be pooled and the primary outcome measure of the pooled data analysis was to demonstrate non-inferiority in 12-week analgesic efficacy of oxycodone PR/naloxone PR versus oxycodone PR alone. Patients with opioid-induced constipation were switched to oxycodone PR and then randomised to fixed doses of oxycodone PR/naloxone PR (n=292) or oxycodone PR (n=295) for 12 weeks (20-80 mg/day). Results: No statistically significant differences in analgesic efficacy were observed for the t... BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=4005348 Tue, 28 Sep 2010 23:00:00 +0100 4005348 http://www.medworm.com/index.php?rid=3978231&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F11 Conclusion: These results should encourage the association and all the involved actors in the HIV/AIDS's program to strengthen counseling, education and information interventions for HIV-infected patients in order to overcome the potential barriers of poor adherence. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3978231 Thu, 16 Sep 2010 23:00:00 +0100 3978231 http://www.medworm.com/index.php?rid=3725319&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F10 Background: Ibuprofen and paracetamol differ in their mode of action and related therapeutic effects, suggesting that combined administration may offer improved analgesia. Reported here are the results of two studies on the pharmacokinetic properties of a novel ibuprofen (200 mg) and paracetamol (500 mg) fixed-dose combination tablet. Methods: Both studies were open-label, randomised studies in healthy volunteers: Study 1 was a four-way crossover, single-dose study; Study 2 was a two-way cross-over, repeat-dose study. Results: Pharmacokinetic parameters for ibuprofen and paracetamol were similar for the combination and monotherapy tablets (values falling within the 80% to 125% acceptable bioequivalence range) except for the rate of absorption of paracetamol from the combination (tmax), whi... BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3725319 Sun, 04 Jul 2010 23:00:00 +0100 3725319 http://www.medworm.com/index.php?rid=3458522&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F9 Conclusions: Traumeel was not superior to placebo in minimizing pain or analgesic consumption over the 14 days of the trial. A transient reduction in the daily maximum post-operative pain score on the day of surgery is of questionable clinical importance. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3458522 Sun, 11 Apr 2010 23:00:00 +0100 3458522 http://www.medworm.com/index.php?rid=3457478&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F8 Conclusions: The Swedish translation of the SAQ demonstrate acceptable construct validity for capturing the frontline perspective of safety culture of community pharmacy staff. The psychometric results reported here met or exceeded standard guidelines, which is consistent with previous studies using the SAQ in other healthcare settings and other languages. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3457478 Sat, 10 Apr 2010 23:00:00 +0100 3457478 http://www.medworm.com/index.php?rid=3412018&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F7 Conclusions: Pentosan treatment in twenty patients with mild knee OA seemed to provide improvements in clinical assessments and C2C level of cartilage metabolism.Trial Registration: UMIN Clinical Trials Registry (UMIN-CTR) UMIN000002790 (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3412018 Sun, 28 Mar 2010 00:00:00 +0100 3412018 http://www.medworm.com/index.php?rid=3375665&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F6 Conclusions: The withdrawal of distalgesic has had positive benefits in terms of IDO presentations to hospital in Ireland and provides evidence supporting the restriction of availability of means as a prevention strategy for suicidal behaviour. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3375665 Thu, 18 Mar 2010 00:00:00 +0100 3375665 http://www.medworm.com/index.php?rid=3273828&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F4 Conclusion: Several characteristics of the primary health care units correlated with adherence to prescribing objectives for rational drug use. Further research on this topic is needed and would constitute valuable information for health care decision makers. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3273828 Mon, 15 Feb 2010 00:00:00 +0100 3273828 http://www.medworm.com/index.php?rid=3218186&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F3 Conclusions: All the samples are pharmaceutical equivalents and the products can be used in antimicrobial therapy. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3218186 Fri, 29 Jan 2010 00:00:00 +0100 3218186 http://www.medworm.com/index.php?rid=3165120&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F2 Conclusion: Quality of reporting RCTs on analgesics after TOS is poor. Reporting of those RCTs should be improved according to methodological standard checklists in the next years. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3165120 Tue, 12 Jan 2010 00:00:00 +0100 3165120 http://www.medworm.com/index.php?rid=3147132&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F10%2F1 Conclusions: These results can be used to quantitate the adipose-blood diffusion limitation as a function of Kow. This is especially important for the highly fat soluble persistent organic chemicals (e.g. polychlorinated biphenyls, dioxins) whose pharmacokinetics are primarily determined by the adipose-blood exchange kinetics. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3147132 Thu, 07 Jan 2010 00:00:00 +0100 3147132 http://www.medworm.com/index.php?rid=3053992&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F19 Conclusions: In terms of Tmax, ibuprofen formulated as a sodium salt was absorbed twice as quickly as from standard ibuprofen acid. The addition of poloxamer to ibuprofen acid did not significantly affect absorption. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3053992 Fri, 04 Dec 2009 00:00:00 +0100 3053992 http://www.medworm.com/index.php?rid=3001388&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F18 Background: Serum paraoxonase (PON1) is a high density lipoprotein (HDL)-associated enzyme involved in organophosphate (OP) degradation and prevention of atherosclerosis. PON1 comprises a potential candidate for in vivo therapeutics, as an anti-atherogenic agent, and for detoxification of pesticides and nerve agents. Because human PON1 exhibits limited stability, engineered, recombinant PON1 (rePON1) variants that were designed for higher reactivity, solubility, stability, and bacterial expression, are candidates for treatment. This work addresses the feasibility of in vivo administration of rePON1, and its HDL complex, as a potentially therapeutic agent dubbed BL-3050. Methods: For stability studies we applied different challenges related to the in vivo disfunctionalization of HDL and PON... BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=3001388 Tue, 17 Nov 2009 00:00:00 +0100 3001388 http://www.medworm.com/index.php?rid=2917678&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F16 Conclusions: Overall, DMSA therapy seems to be reasonably safe, effective in removing several toxic metals (especially lead), dramatically effective in normalizing RBC glutathione, and effective in normalizing platelet counts. Only 1 round (3 days) was sufficient to improve glutathione and platelets. Additional rounds increased excretion of toxic metals. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2917678 Thu, 22 Oct 2009 23:00:00 +0100 2917678 http://www.medworm.com/index.php?rid=2917677&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F17 This study investigated the effects of oral dimercapto succinic acid (DMSA) therapy on the behavioural symptoms of children with autism spectrum disorders (ASD) ages 3-8 years. Methods: Phase 1 involved 65 children with ASD who received one round of DMSA (3 days). Participants who had high urinary excretion of toxic metals were selected to continue on to phase 2. In phase 2, 49 participants were randomly assigned in a double-blind design to receive an additional 6 rounds of either DMSA or placebo. Results: The groups receiving one round and seven rounds of DMSA had significant improvements on all the assessment measures. The degree of improvement on the assessment measures could be partially explained by a regression analysis based on excretion of toxic metals and changes in glutathione (a... BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2917677 Thu, 22 Oct 2009 23:00:00 +0100 2917677 http://www.medworm.com/index.php?rid=2769430&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F15 Conclusions: Risk factor treatment needs optimisation. Risk factor management, systematic medication reviews, and screening for and management of potential drug-drug interactions deserve great attention. Clinical pharmacy services could help in the achievement of treatment goals. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2769430 Sat, 05 Sep 2009 23:00:00 +0100 2769430 http://www.medworm.com/index.php?rid=2689732&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F14 Conclusions: The knowledge of ADRs and how to report them are inadequate among doctors working in a teaching hospital in Lagos, Nigeria. More awareness should be created on the Yellow Card reporting scheme. Continuous medical education, training and integration of ADR reporting into the clinical activities of the doctors would likely improve reporting. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2689732 Mon, 10 Aug 2009 23:00:00 +0100 2689732 http://www.medworm.com/index.php?rid=2661580&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F13 Conclusion: No pharmacological interaction occurred between selegiline and a substantial dose of intravenous cocaine, suggesting the combination will be safe in pharmacotherapy trials. Selegiline produced few changes in subjective response to the cocaine challenge perhaps because of some psychoactive neurotransmitters changing in opposite directions. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2661580 Fri, 31 Jul 2009 23:00:00 +0100 2661580 http://www.medworm.com/index.php?rid=2443874&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F12 Conclusions: Buspirone in the maximal recommended dose was without significant effect on thermal pain. However, as it is only a partial agonist at the 5-HT1A receptor and also acts on other receptor types, the negative results of the present study do not rule out a possible analgesic effect of more specific 5-HT1A receptor agonists. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2443874 Fri, 29 May 2009 04:00:00 +0100 2443874 http://www.medworm.com/index.php?rid=2437740&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F11 Background: Multiple medications is a well-known potential risk factor in terms of patient's health. The aim of the present study was to estimate the prevalence of dispensed drugs and multiple medications in an entire national population, by using individual based data on dispensed drugs. Methods: Analyses of all dispensed out-patient prescriptions in 2006 from the Swedish prescribed drug register. As a cut-off for multiple medications, we applied five or more different drugs dispensed (DP[greater than or equal to]5) at Swedish pharmacies for a single individual during a 3-month, a 6-month, and a 12-month study period. For comparison, results were also calculated with certain drug groups excluded. Results: 6.2 million individuals received at least one dispensed drug (DP[greater than or equ... BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2437740 Wed, 27 May 2009 04:00:00 +0100 2437740 http://www.medworm.com/index.php?rid=2429447&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F10 Conclusions: HX575 and the comparator epoetin alfa were bioequivalent at steady state circulating drug concentrations with respect to their pharmacokinetic profile and pharmacodynamic action. This supports the conclusion that HX575 and the comparator epoetin alfa, when administered intraveneously, will be equally efficacious and may be interchangeable as therapy. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2429447 Fri, 22 May 2009 04:00:00 +0100 2429447 http://www.medworm.com/index.php?rid=2407573&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F9 Conclusions: The Intensive Care Section performed best as far as quality of prescription writing was concerned when compared with the Medical and Surgical Sections. Nevertheless the overall illegibility and incompleteness (above 20%) are unacceptably high. Values need to be improved by enhancing the safety culture and in particular the awareness of the professionals on the consequences that a bad prescription writing can produce. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2407573 Wed, 13 May 2009 04:00:00 +0100 2407573 http://www.medworm.com/index.php?rid=2391767&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F8 Conclusions: ADRs cause 5.8% of admissions in medical departments in the primary city and tertiary referral hospital. The physicians recognise certain ADR related admissions according to WHO causality criteria and note them in medical records, but they rarely code and report ADRs. The established frequency of ADR related admissions depends on the detection method, department specialty and frequency of urgently admitted patients. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2391767 Mon, 04 May 2009 04:00:00 +0100 2391767 http://www.medworm.com/index.php?rid=2370980&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F7 Conclusions: Fatal drug poisonings is a relatively common cause of death in Sweden. By using multiple sources of information when investigating the proportion of fatal poisonings in a population, more accurate estimates may be obtained. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2370980 Mon, 27 Apr 2009 04:00:00 +0100 2370980 http://www.medworm.com/index.php?rid=2307975&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F6 Background: Simvastatin reduces cardiovascular mortality and morbidity but, as with other HMG-CoA reductase inhibitors, can cause significant muscle toxicity and has been associated with elevations of liver transaminases. Methods: Muscle and liver adverse effects of simvastatin 40mg daily were evaluated in a randomized placebo-controlled trial involving 20,536 UK patients with vascular disease or diabetes (in which a substantial reduction of cardiovascular mortality and morbidity has previously been demonstrated). Results: The excess incidence of myopathy in the simvastatin group was (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2307975 Tue, 31 Mar 2009 04:00:00 +0100 2307975 http://www.medworm.com/index.php?rid=2307976&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F5 Conclusions: All sequelae were still present six years after the initial poisoning suggesting that these were irreversible damages. On follow-up, apparently new neurological and visual complications were identified in 36% and 36%, respectively. 35% of the patients initially discharged with sequelae and 29% discharged without were dead six years later; 27% of them from alcohol intoxication. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2307976 Fri, 27 Mar 2009 04:00:00 +0100 2307976 http://www.medworm.com/index.php?rid=2230476&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F4 Conclusion: Although the drugs were launched in different decades, approaches to the ADR studies were similar for all three therapeutic cases: antibiotics, NSAIDs and SSRIs. Both descriptive and analytical designs were applied. Despite the fact that analytical studies rank higher in the evidence hierarchy, only the lower ranking descriptive case reports/spontaneous reports provided information about new and previously undetected ADRs. This review underscores the importance of systems for spontaneous reporting of ADRs. Therefore, spontaneous reporting should be encouraged further and the information in ADR databases should continuously be subjected to systematic analysis. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2230476 Tue, 03 Mar 2009 05:00:00 +0100 2230476 http://www.medworm.com/index.php?rid=2189817&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F3 Conclusions: Propanil is the most lethal herbicide in Sri Lanka after paraquat. Methylene blue was largely prescribed in low doses and administered as intermittent boluses which are expected to be suboptimal given the kinetics of methylene blue, propanil and the DCA metabolite. But in the absence of controlled studies the efficacy of these and other treatments is poorly defined. More research is required into the optimal management of acute propanil poisoning. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2189817 Mon, 16 Feb 2009 05:00:00 +0100 2189817 http://www.medworm.com/index.php?rid=2140305&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F2 Conclusions: AVI-014 has safety, pharmacokinetic, and pharmacodynamic properties comparable to filgrastim at an equal dose in healthy volunteers. These findings support further investigation in AVI-014. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2140305 Wed, 28 Jan 2009 05:00:00 +0100 2140305 http://www.medworm.com/index.php?rid=2109694&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F9%2F1 Background: Demonstration of equivalent amounts of the same active pharmaceutical ingredient (API) between generic and innovator products (pharmaceutical equivalence) is a basic requirement of regulatory agencies for intravenous generic drugs prior to clinical use, and constitutes the pivotal point to assume therapeutic equivalence. Physicochemical methods are preferred instead of biological assays to determine concentration of drugs in biological fluids, but it does not permit direct quantification of potency. Here, we report a microbiological assay using large plates designed to determine potency and concentration of pharmaceutical-grade antibiotics for injection and a statistical method to assess the in vitro equivalence of generic products with respect to the innovator. Methods: The as... BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2109694 Fri, 16 Jan 2009 05:00:00 +0100 2109694 http://www.medworm.com/index.php?rid=2009765&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F12 Conclusion: The study suggests that orally administered 0.8 mg of salmon calcitonin was effective in suppression of serum CTX irrespective of time of dosing. The pre-dinner dosing resulted in optimum efficacy response corresponding to an overall suppression of bone resorption by 25%. Trial registration: NCT00411125 (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2009765 Thu, 04 Dec 2008 05:00:00 +0100 2009765 http://www.medworm.com/index.php?rid=1923132&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F11 Conclusions: Dexketoprofen was at least as effective as other NSAIDs and paracetamol/opioid combinations. While adverse event withdrawal was not different between dexketoprofen and comparator analgesics, the different conditions and comparators studies precluded any formal analysis. Exposure was limited, and no conclusions could be drawn about safety in terms of serious adverse events like gastrointestinal bleeding or cardiovascular events. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1923132 Fri, 31 Oct 2008 04:00:00 +0100 1923132 http://www.medworm.com/index.php?rid=1913637&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F10 Background: Prior studies suggested low density lipoprotein particle (LDLP) size is a predictor of atherosclerosis. Knowledge of effects of lipid lowering drugs on lipoprotein subclasses is useful. We treated subjects with hyperlipidemia sequentially with statins and fibrates, the 2 classes of lipid lowering therapy and studied changes in NMR lipoprotein subclasses. Methods: 35 subjects (21 males; 60+/-12 y) were enrolled in a crossover study. Subjects had baseline lipid profile & apoB. Lipoprotein subclasses, particle numbers and diameters were assessed with NMR spectroscopy. Subjects were randomized to simvastatin 20mg or fenofibrate 200 mg. Repeat testing was done at 12 weeks. After 6 week washout, subjects were started on alternate drug for 12 weeks with pre/post tests. Results: Both t... BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1913637 Tue, 28 Oct 2008 04:00:00 +0100 1913637 http://www.medworm.com/index.php?rid=1836128&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F9 Conclusion: The physicians did not review medication charts on all ward rounds and there was considerable variation in how often they did this. There is some evidence that the frequency with which charts are reviewed decreases as the number of patients seen increases. More efforts should be made to encourage regular review of medication charts. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1836128 Mon, 29 Sep 2008 04:00:00 +0100 1836128 http://www.medworm.com/index.php?rid=1812247&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F8 Conclusions: The prescribing guidelines booklet is frequently used and is generally appreciated, though differences exist between subgroups of users. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1812247 Mon, 22 Sep 2008 04:00:00 +0100 1812247 http://www.medworm.com/index.php?rid=1796925&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F7 Conclusions: Our data suggest that plasma platinum levels are related to time, age, dose, GFR, and STS use. Platinum in plasma, probably, represent platinum eliminated from regenerating tissue. Platinum species in pUF were partly present in a reactive form. The effects of the reactivity on long-term consequences of Pt-containing chemotherapy, however, remains to be established. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1796925 Wed, 17 Sep 2008 04:00:00 +0100 1796925 http://www.medworm.com/index.php?rid=1781606&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F6 Conclusions: Clinicians should be aware of the increased risk of impaired fasting glucose in these groups, and use of thiazides should not in itself deter its use as a first-line antihypertensive agent among ethnic Chinese patients. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1781606 Wed, 10 Sep 2008 04:00:00 +0100 1781606 http://www.medworm.com/index.php?rid=1778020&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F5 Conclusion: 0.8 mg sCT with 50 ml of water taken 30 and 60 minutes prior to meal time resulted in optimal pharmacodynamic and pharmacokinetic parameters. The data suggest that this novel oral formulation may have improved absorption and reduction of bone resorption compared to that of the nasal form. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1778020 Tue, 09 Sep 2008 04:00:00 +0100 1778020 http://www.medworm.com/index.php?rid=1641606&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F4 Conclusions: Inhaled l-methamphetamine delivered from a non-prescription product produced minimal effects but may be a cardiodepressant. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1641606 Mon, 21 Jul 2008 04:00:00 +0100 1641606 http://www.medworm.com/index.php?rid=1553912&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F3 Conclusion: The trainee practitioners provided effective and safe inhalation sedation. This challenges the current French restriction of the 50% nitrous oxide in oxygen premix to the hospital setting. Further emphasis is required on the teaching of behaviour management skills for patients with intellectual disability. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1553912 Wed, 11 Jun 2008 04:00:00 +0100 1553912 http://www.medworm.com/index.php?rid=1505850&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F3 Conclusion: The trainee practitioners provided effective and safe inhalation sedation. This challenges the current French restriction of the 50% nitrous oxide in oxygen premix to the hospital setting. Further emphasis is required on the teaching of behaviour management skills for patients with intellectual disability. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1505850 Wed, 11 Jun 2008 04:00:00 +0100 1505850 http://www.medworm.com/index.php?rid=1339304&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F2 Conclusions: In myeloma patients receiving maintenance therapy, the combination of zoledronic acid and thalidomide appears to confer no additional renal safety risks over zoledronic acid alone. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1339304 Mon, 31 Mar 2008 04:00:00 +0100 1339304 http://www.medworm.com/index.php?rid=1307155&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F8%2F1 Background: Due to few paediatric drug safety studies, knowledge on risks of drug treatment in children is limited. The knowledge needs to be increased to make proper risk-benefit analyses possible when treating paediatric patients with drugs. The aim of the present study was to investigate drug groups commonly used in children concerning type and frequency of individual case safety reports in children. Methods: Number and type of individual case safety reports in the 30 groups of drugs (5th level ATC-code) most sold (number of defined daily doses) in outpatient treatment to children ( (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1307155 Mon, 17 Mar 2008 04:00:00 +0100 1307155 http://www.medworm.com/index.php?rid=1070773&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F7%2F14 Conclusion: Although differences in age-distribution seems to be an important source of variation in statin consumption, it cannot account for the total variation between counties in Norway. Variations in prevalences of use, and treatment intensity in terms of PDD and choice of statin also affect the total consumption. The results in this study seems to correspond to previous findings of more frequent statin use in primary prevention, and more statin users achieving lipid goal in the highest consuming county. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=1070773 Wed, 05 Dec 2007 05:00:00 +0100 1070773 http://www.medworm.com/index.php?rid=972021&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F7%2F13 Conclusion: The identification of bortezomib and its analog as potent antimalarial drugs will set the stage for the advancement of this class of compounds alone or in combination therapy for treatment of malaria, and emphasize the need for large-scale screens to identify new antimalarials within the library of clinically approved compounds. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=972021 Tue, 23 Oct 2007 04:00:00 +0100 972021 http://www.medworm.com/index.php?rid=959420&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F7%2F12 Conclusion: An e-mail with a drug information attachment may influence sales of prescribed drugs. No difference between different designs of the attachment could be detected. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=959420 Thu, 18 Oct 2007 04:00:00 +0100 959420 http://www.medworm.com/index.php?rid=901940&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F7%2F9 Conclusions: ADRs have major public health and economic implications. Our data suggest that national Hospital Episode Statistics in England have recognised limitations and that consequently, admissions associated with adverse drug reactions continue to be under- recorded. External causes of ADR have increased at a greater rate than the increase in total hospital admissions. Improved and more detailed reporting combined with educational interventions to improve the recording of ADRs are needed to accurately monitor the morbidity caused by ADRs and to meaningfully evaluate national initiatives to reduce adverse drug reactions. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=901940 Tue, 25 Sep 2007 04:00:00 +0100 901940 http://www.medworm.com/index.php?rid=763423&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F7%2F8 Conclusions: The study shows that ADRs leading to hospitalization are frequent and constitute a significant economic burden. Training of patients and prescribers may lead to a reduction in hospitalization due to avoidable ADRs and thus lessen their economic burden. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=763423 Sat, 28 Jul 2007 04:00:00 +0100 763423 http://www.medworm.com/index.php?rid=740957&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F7%2F7 Conclusions: TP in peripheral mononuclear blood cells was hardly regulated under therapy with paclitaxel. Therefore, no further increase in haematotoxicity due to TP upregulation is expected from combination therapy of taxanes and capecitabine. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=740957 Wed, 18 Jul 2007 04:00:00 +0100 740957 http://www.medworm.com/index.php?rid=725759&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F7%2F6 Conclusion: The frequency of poor metabolizers (1.1%) in the Colombian mestizos included in this study is similar to that in Bolivian mestizos (1%) but lower than in Mexican-Americans (3.2%), West Mexicans (6%), Caucasians (5%) and African Americans (5.4%). The results of this study will be useful for drug dosage recommendations in Colombian mestizos. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=725759 Wed, 11 Jul 2007 04:00:00 +0100 725759 http://www.medworm.com/index.php?rid=666058&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F7%2F5 Conclusions: Deficits in attention may only be present in methadone-treated early phase OST patients and may be dose-dependent. Working memory deficit is common in both patient groups. Verbal memory deficit may be more pronounced in methadone-treated patients than in buprenorphine/naloxone-treated patients. In sum, to preserve cognitive function in early OST, the use of buprenorphine/naloxone may be more preferable to methadone use of, at least if buprenorphine has been recently abused and when benzodiazepine comedication is used. Longitudinal studies are needed to investigate if the better performance of buprenorphine/naloxone-treated patients is a relatively permanent effect or reflects only transient opioid switching effect. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=666058 Tue, 12 Jun 2007 04:00:00 +0100 666058 http://www.medworm.com/index.php?rid=627150&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F7%2F4 Conclusion: Taken together with the other observations of differences in effects, we conclude that the claim that all β-adrenergic blockers are inferior drugs for hypertensive patients should be rejected. Atenolol is not representative of the β-adrenergic blocker class of drugs as a whole and is thus not a suitable drug for comparisons with other antihypertensive drugs in terms of effect. The non-atenolol β-adrenergic blockers should thus continue to be fundamental in antihypertensive drug treatments. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=627150 Tue, 08 May 2007 04:00:00 +0100 627150 http://www.medworm.com/index.php?rid=409396&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F7%2F2 Conclusions: Standard bioavailability measures show minimal effect of food on the bioavailability of hydromorphone from OROS(r) hydromorphone. Naltrexone co-administration results in a slight increase in the rate of absorption but not the extent of absorption. Trial Registration: Clinical Trials.gov NCT00399295 (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=409396 Fri, 02 Feb 2007 07:00:00 +0100 409396 http://www.medworm.com/index.php?rid=248480&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F6%2F8 Conclusion: A genotyping evaluation would better help in identifying population specific genotypes and thus help individualize drug therapy. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=248480 Tue, 24 Oct 2006 06:00:00 +0100 248480 http://www.medworm.com/index.php?rid=226576&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F6%2F7 Background: Finasteride is a competitive inhibitor of 5 alpha-reductase enzyme, and is used for treatment of benign prostatic hyperplasia and androgenetic alopecia. Animal studies have shown that finasteride might induce behavioral changes. Additionally, some cases of finasteride-induced depression have been reported in humans. The purpose of this study was to examine whether depressive symptoms or anxiety might be induced by finasteride administration. Methods: One hundred and twenty eight men with androgenetic alopecia, who were prescribed finasteride (1mg/day) were enrolled in this study. Information on depressed mood and anxiety was obtained by Beck Depression Inventory (BDI), and Hospital Anxiety and Depression Scale (HADS). Participants completed BDI and HADS questionnaires before be... BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=226576 Sat, 07 Oct 2006 06:00:00 +0100 226576 http://www.medworm.com/index.php?rid=448874&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F6%2F7 Conclusion: This preliminary study suggests that finasteride might induce depressive symptoms; therefore this medication should be prescribed cautiously for patients with high risk of depression. It seems that further studies would be necessary to determine behavioral effects of this medication in higher doses and in more susceptible patients. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=448874 Sat, 07 Oct 2006 04:00:00 +0100 448874 http://www.medworm.com/index.php?rid=195664&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F6%2F6 Conclusions: The present data indicate an accumulation of sulphobutylether beta cyclodextrin sodium in patients treated with intravenous voriconazole and dialysis therapy. Fortunately, no toxic effects were observed, although the accumulated dose values were lower but comparable with those used in previous toxicity studies with animals. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=195664 Mon, 18 Sep 2006 06:00:00 +0100 195664 http://www.medworm.com/index.php?rid=134692&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F6%2F4 Conclusions: We present the first systematic pharmacokinetic analysis of compounds derived from maritime pine bark extract. Beyond the known constituents and metabolites we uncovered the plasma time courses of ten unknown compounds. In concert with our previous detection of anti-inflammatory bioefficacy of these plasma samples ex vivo we suggest that constituents and metabolites of Pycnogenol bear potential for disclosure of novel active principles. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=134692 Thu, 03 Aug 2006 06:00:00 +0100 134692 http://www.medworm.com/index.php?rid=2301&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F6%2F3 Conclusion: Serum sickness-like reaction may be associated with cefazolin therapy. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2301 Thu, 23 Feb 2006 07:00:00 +0100 2301 http://www.medworm.com/index.php?rid=2302&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F6%2F2 Conclusion: We have developed an HPLC method using UV detection capable of quantifying 1 nM of docetaxel in plasma samples. The method should be useful for pharmacokinetic determinations at all relevant doses of docetaxel. Using a similar methodology paclitaxel can be quantified down to a concentration of 1.2 nM in plasma with acceptable accuracy and precision. We further demonstrate that the previously reported negative influence of Cremophor EL on assay performance may be overcome by degradation of the detergent by incubation with lipase. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2302 Fri, 13 Jan 2006 07:00:00 +0100 2302 http://www.medworm.com/index.php?rid=2303&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F6%2F1 Conclusion: If the in vitro plasma binding kinetics of the ACE inhibitor for the two binding sites are known, a unique PBPK model description of the Griensven et. al. experimental data can be obtained. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2303 Fri, 06 Jan 2006 07:00:00 +0100 2303 http://www.medworm.com/index.php?rid=2304&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F5%2F5 Conclusion: Recombinant SK was associated with a similar post-marketing safety profile to those suggested in previous clinical trials. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2304 Wed, 02 Nov 2005 07:00:00 +0100 2304 http://www.medworm.com/index.php?rid=2305&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F5%2F4 Conclusion: The current data suggest that the expression of CYP2C, CYP2E1, and CYP3A5 varies in different parts of the colon. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2305 Thu, 27 Oct 2005 06:00:00 +0100 2305 http://www.medworm.com/index.php?rid=2306&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F5%2F3 DiscussionThere is a burgeoning understanding of the cellular mechanisms that control the etiology and pathogeneses of diseases. This understanding both enables and motivates the development of drugs that induce a specific action in a selected cell population; i.e., a targeted treatment. Consequently, drugs that can target distinct molecular targets involved in pathologic/pathogenetic processes, or signal-transduction pathways, are being developed.However, in most cases, diseases involve multiple abnormalities. A disease may be associated with more than one dysfunctional protein and these may be out-of-balance with each other. Likewise a drug might strongly target a protein that shares a similar active domain with other proteins. A drug may also target pleiotropic cytokines, or other prote... BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2306 Tue, 26 Apr 2005 06:00:00 +0100 2306 http://www.medworm.com/index.php?rid=2307&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F5%2F2 Conclusion: The bioavailability of daidzein, which was adjusted for the administered dose (AUC/dose), following a single oral administration of soy beverage was slightly (but significantly) less than that of soy extract capsules, whereas, the bioavailability adjusted for administered dose of genistein from both soy preparations were comparable. The other pharmacokinetic parameters of daidzein and genistein, including Cmax adjusted for the dose, Tmax and t1/2, were not different between both soy preparations. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2307 Thu, 03 Mar 2005 07:00:00 +0100 2307 http://www.medworm.com/index.php?rid=2308&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F5%2F1 Conclusion: Hematology-oncology services are intense antifungal drug prescribing areas. Fluconazole and other azol antifungal drugs are the most prescribed drugs in all patient care areas while amphotericin B use has considerably decreased. The data may be useful as a benchmark for focused interventions to improve prescribing quality. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2308 Thu, 10 Feb 2005 07:00:00 +0100 2308 http://www.medworm.com/index.php?rid=2309&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F4%2F7 Conclusion: These findings indicate that serum concentrations of morphine and morphine metabolites fluctuate. The fluctuations found in our study are not explained by changes in morphine doses, administration of other drugs or by time for collection of blood samples. As expected the day-to-day variation was lower in patients receiving continuous sc morphine infusions compared with patients receiving oral morphine. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2309 Mon, 04 Oct 2004 06:00:00 +0100 2309 http://www.medworm.com/index.php?rid=2310&cid=s_32534_13_f&fid=32534&url=http%3A%2F%2Fwww.biomedcentral.com%2F1472-6904%2F4%2F6 Conclusion: The episodes of intrathecal baclofen withdrawal syndrome are mostly caused by preventable human errors or pump malfunction. Educating patients and their caregivers about the syndrome, and regular check-up of baclofen pump may decrease the incidence of intrathecal baclofen withdrawal syndrome. Oral baclofen replacement may not be an effective method to treat or prevent intrathecal baclofen withdrawal syndrome. Management includes an early recognition of syndrome, proper intensive care management, high-dose benzodiazepines and prompt analysis of intrathecal pump with reinstitution of baclofen. (Source: BMC Clinical Pharmacology) BMC Clinical Pharmacology journals http://www.medworm.com/rss/comments.php?id=2310 Mon, 09 Aug 2004 06:00:00 +0100 2310